23
Views
66
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Activation of Rho-Dependent Cell Spreading and Focal Adhesion Biogenesis by the v-Crk Adaptor Protein

, , , , , , , , & show all
Pages 3044-3058 | Received 01 Oct 1997, Accepted 02 Feb 1998, Published online: 28 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Sun-Ju Yi, Seong Yun Hwang, Myung-ju Oh, Kyunghwan Kim & Byung H. Jhun. (2018) Carboxy-terminal domain of Cas differentially modulates c-Jun expression, DNA synthesis, and membrane ruffling induced by insulin, EGF, and IGF-1. Animal Cells and Systems 22:2, pages 69-75.
Read now
Yoshihisa Nojima. (1999) Structure and function of the p130Cas-related protein family. Japanese Journal of Rheumatology 9:2, pages 123-133.
Read now
Kristen Senechal, Conor Heaney, Brian Druker & Charles L. Sawyers. (1998) Structural Requirements for Function of the Crkl Adapter Protein in Fibroblasts and Hematopoietic Cells. Molecular and Cellular Biology 18:9, pages 5082-5090.
Read now

Articles from other publishers (63)

Masayuki Tsuneki & Joseph A. Madri. (2016) CD44 Influences Fibroblast Behaviors Via Modulation of Cell-Cell and Cell-Matrix Interactions, Affecting Survivin and Hippo Pathways. Journal of Cellular Physiology 231:3, pages 731-743.
Crossref
Alex Braiman & Noah Isakov. (2015) The Role of Crk Adaptor Proteins in T-Cell Adhesion and Migration. Frontiers in Immunology 6.
Crossref
P P Shah, M Y Fong & S S Kakar. (2011) PTTG induces EMT through integrin αVβ3-focal adhesion kinase signaling in lung cancer cells. Oncogene 31:26, pages 3124-3135.
Crossref
Britta George, Rakesh Verma, Abdulsalam A. Soofi, Puneet Garg, Jidong Zhang, Tae-Ju Park, Laura Giardino, Larisa Ryzhova, Duncan B. Johnstone, Hetty Wong, Deepak Nihalani, David J. Salant, Steven K. Hanks, Tom Curran, Maria Pia Rastaldi & Lawrence B. Holzman. (2012) Crk1/2-dependent signaling is necessary for podocyte foot process spreading in mouse models of glomerular disease. Journal of Clinical Investigation 122:2, pages 674-692.
Crossref
Myeong Gu Yeo, Hye Jin Oh, Hong-Suk Cho, Jang Soo Chun, Eugene E. Marcantonio & Woo Keun Song. (2011) Phosphorylation of Ser 21 in Fyn regulates its kinase activity, focal adhesion targeting, and is required for cell migration. Journal of Cellular Physiology 226:1, pages 236-247.
Crossref
B Titz, T Low, E Komisopoulou, S S Chen, L Rubbi & T G Graeber. (2010) The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization. Oncogene 29:44, pages 5895-5910.
Crossref
Asuka Kaizaki, Sachiko Tanaka, Kenji Tsujikawa, Satoshi Numazawa & Takemi Yoshida. (2010) Recreational drugs, 3,4-Methylenedioxymethamphetamine(MDMA), 3,4-methylenedioxyamphetamine (MDA) and diphenylprolinol, inhibit neurite outgrowth in PC12 cells. The Journal of Toxicological Sciences 35:3, pages 375-381.
Crossref
Aaron Zefrin Fernandis & Markus Rene Wenk. (2009) Lipid-based biomarkers for cancer. Journal of Chromatography B 877:26, pages 2830-2835.
Crossref
Wei-Gang Duan, Jing Shang, Zhen-Zhou Jiang, Jin-Cheng Yao, Yu Yun, Ming Yan, Bin Shu, Qing Lin, Ze-Pu Yu & Lu-Yong Zhang. (2009) Rho Kinase Inhibitor Y-27632 Down-Regulates Norepinephrine Synthesis and Release in PC12 Cells. Basic & Clinical Pharmacology & Toxicology 104:6, pages 434-440.
Crossref
Fengyu Qiao, Chun Y. Gao, Brajendra K. Tripathi & Peggy S. Zelenka. (2008) Distinct functions of Cdk5(Y15) phosphorylation and Cdk5 activity in stress fiber formation and organization. Experimental Cell Research 314:19, pages 3542-3550.
Crossref
Arayo Haga, Kazunori Hashimoto, Nobutada Tanaka, Kazuo T. Nakamura & Yoshihiro Deyashiki. (2008) Scalable purification and characterization of the extracellular domain of human autotaxin from prokaryotic cells. Protein Expression and Purification 59:1, pages 9-17.
Crossref
Myeong Gu Yeo, Bong Hwan Sung, Hye Jin Oh, Zee Yong Park, Eugene E. Marcantonio & Woo Keun Song. (2008) Focal adhesion targeting of v-Crk is essential for FAK phosphorylation and cell migration in mouse embryo fibroblasts deficient src family kinases or p130CAS. Journal of Cellular Physiology 214:3, pages 604-613.
Crossref
Philip T. Cagle, Jaishree Jagirdar & Helmut H. Popper. 2008. Dail and Hammar’s Pulmonary Pathology. Dail and Hammar’s Pulmonary Pathology 47 157 .
Ka-Wing Wong, Sina Mohammadi & Ralph R. Isberg. (2006) Disruption of RhoGDI and RhoA Regulation by a Rac1 Specificity Switch Mutant. Journal of Biological Chemistry 281:52, pages 40379-40388.
Crossref
Gayathri Swaminathan & Alexander Y. Tsygankov. (2006) The Cbl family proteins: Ring leaders in regulation of cell signaling. Journal of Cellular Physiology 209:1, pages 21-43.
Crossref
Anjali M. Teckchandani, Tracee S. Panetti & Alexander Y. Tsygankov. (2005) c-Cbl regulates migration of v-Abl-transformed NIH 3T3 fibroblasts via Rac1. Experimental Cell Research 307:1, pages 247-258.
Crossref
Abdelhafid Saci & Christopher L. Carpenter. (2005) RhoA GTPase Regulates B Cell Receptor Signaling. Molecular Cell 17:2, pages 205-214.
Crossref
Toshinori Iwahara, Tsuyoshi Akagi, Yuki Fujitsuka & Hidesaburo Hanafusa. (2004) CrkII regulates focal adhesion kinase activation by making a complex with Crk-associated substrate, p130 Cas . Proceedings of the National Academy of Sciences 101:51, pages 17693-17698.
Crossref
Masumi Tsuda, Yoshinori Makino, Toshinori Iwahara, Hiroshi Nishihara, Hirofumi Sawa, Kazuo Nagashima, Hidesaburo Hanafusa & Shinya Tanaka. (2004) Crk Associates with ERM Proteins and Promotes Cell Motility toward Hyaluronic Acid. Journal of Biological Chemistry 279:45, pages 46843-46850.
Crossref
Oliver Stork, Alexander Zhdanov, Alexei Kudersky, Takeo Yoshikawa, Kunihiko Obata & Hans-Christian Pape. (2004) Neuronal Functions of the Novel Serine/Threonine Kinase Ndr2. Journal of Biological Chemistry 279:44, pages 45773-45781.
Crossref
Yona Goldshmit, Claire E. Walters, Hannah J. Scott, Christopher J. Greenhalgh & Ann M. Turnley. (2004) SOCS2 Induces Neurite Outgrowth by Regulation of Epidermal Growth Factor Receptor Activation. Journal of Biological Chemistry 279:16, pages 16349-16355.
Crossref
Dale D. Tang, Christopher E. Turner & Susan J. Gunst. (2003) Expression of Non‐Phosphorylatable Paxillin Mutants in Canine Tracheal Smooth Muscle Inhibits Tension Development. The Journal of Physiology 553:1, pages 21-35.
Crossref
Toshinori Iwahara, Tsuyoshi Akagi, Tomoyuki Shishido & Hidesaburo Hanafusa. (2003) CrkII induces serum response factor activation and cellular transformation through its function in Rho activation. Oncogene 22:38, pages 5946-5957.
Crossref
Takahisa Takino, Masahito Tamura, Hisashi Miyamori, Masaru Araki, Kazue Matsumoto, Hiroshi Sato & Kenneth M. Yamada. (2003) Tyrosine phosphorylation of the CrkII adaptor protein modulates cell migration. Journal of Cell Science 116:15, pages 3145-3155.
Crossref
Gordon B. Mills & Wouter H. Moolenaar. (2003) The emerging role of lysophosphatidic acid in cancer. Nature Reviews Cancer 3:8, pages 582-591.
Crossref
Darren R. Tyson, Selena Larkin, Yousuke Hamai & Ralph A. Bradshaw. (2003) PC12 cell activation by epidermal growth factor receptor: role of autophosphorylation sites. International Journal of Developmental Neuroscience 21:2, pages 63-74.
Crossref
Louie LamorteIsabelle Royal, Monica Naujokas & Morag Park. (2002) Crk Adapter Proteins Promote an Epithelial–Mesenchymal-like Transition and Are Required for HGF-mediated Cell Spreading and Breakdown of Epithelial Adherens Junctions. Molecular Biology of the Cell 13:5, pages 1449-1461.
Crossref
Liang-Tung Yang, Konstantina Alexandropoulos & Jan Sap. (2002) c-SRC Mediates Neurite Outgrowth through Recruitment of Crk to the Scaffolding Protein Sin/Efs without Altering the Kinetics of ERK Activation. Journal of Biological Chemistry 277:20, pages 17406-17414.
Crossref
Sundararajah Thevananther, Angel Rivera & Scott A. Rivkees. (2001) A1 adenosine receptor activation inhibits neurite process formation by rho kinase-mediated pathways. Neuroreport 12:14, pages 3057-3063.
Crossref
Robin D. Kim, Chad E. Darling, Timothy P. Roth, Rocco Ricciardi & Ravi S. Chari. (2001) Activator Protein 1 Activation following Hypoosmotic Stress in HepG2 Cells Is Actin Cytoskeleton Dependent. Journal of Surgical Research 100:2, pages 176-182.
Crossref
Katherine M. Giles, Katherine Ross, Adriano G. Rossi, Neil A. Hotchin, Christopher Haslett & Ian Dransfield. (2001) Glucocorticoid Augmentation of Macrophage Capacity for Phagocytosis of Apoptotic Cells Is Associated with Reduced p130Cas Expression, Loss of Paxillin/pyk2 Phosphorylation, and High Levels of Active Rac. The Journal of Immunology 167:2, pages 976-986.
Crossref
Pamela J. Bruce-Staskal & Amy H. Bouton. (2001) PKC-Dependent Activation of FAK and Src Induces Tyrosine Phosphorylation of Cas and Formation of Cas–Crk Complexes. Experimental Cell Research 264:2, pages 296-306.
Crossref
Anjali M Teckchandani, Elena A Feshchenko & Alexander Y Tsygankov. (2001) c-Cbl facilitates fibronectin matrix production by v-Abl-transformed NIH3T3 cells via activation of small GTPases. Oncogene 20:14, pages 1739-1755.
Crossref
Agnes Zvara, J Eduardo Fajardo, Marcela Escalante, Graham Cotton, Tom Muir, Kathrin H Kirsch & Raymond B Birge. (2001) Activation of the focal adhesion kinase signaling pathway by structural alterations in the carboxyl-terminal region of c-Crk II. Oncogene 20:8, pages 951-961.
Crossref
Wai-chi Ho, Shashi Uniyal, Susan O. Meakin, Vincent L. Morris & Bosco M.C. Chan. (2001) A Differential Role of Extracellular Signal-Regulated Kinase in Stimulated PC12 Pheochromocytoma Cell Movement. Experimental Cell Research 263:2, pages 254-264.
Crossref
Jord C. Stam, WillieJ.C. Geerts, HenriH. Versteeg, ArieJ. Verkleij & PaulM.P.van Bergen en Henegouwen. (2001) The v-Crk Oncogene Enhances Cell Survival and Induces Activation of Protein Kinase B/Akt. Journal of Biological Chemistry 276:27, pages 25176-25183.
Crossref
Cecilia Annerén, Kris A. Reedquist, Johannes L. Bos & Michael Welsh. (2000) GTK, a Src-related Tyrosine Kinase, Induces Nerve Growth Factor-independent Neurite Outgrowth in PC12 Cells through Activation of the Rap1 Pathway. Journal of Biological Chemistry 275:37, pages 29153-29161.
Crossref
Marcela Escalante, Jody Courtney, Wai Gong Chin, Kenneth K. Teng, Jong-Il Kim, J. Eduardo Fajardo, Bruce J. Mayer, Barbara L. Hempstead & Raymond B. Birge. (2000) Phosphorylation of c-Crk II on the Negative Regulatory Tyr222 Mediates Nerve Growth Factor-induced Cell Spreading and Morphogenesis. Journal of Biological Chemistry 275:32, pages 24787-24797.
Crossref
Sam W. Lee, Li Fang, Makoto Igarashi, Toru Ouchi, Kun Ping Lu & Stuart A. Aaronson. (2000) Sustained activation of Ras/Raf/mitogen-activated protein kinase cascade by the tumor suppressor p53. Proceedings of the National Academy of Sciences 97:15, pages 8302-8305.
Crossref
Eyleen L.K. Goh, Tao Zhu, Shoshana Yakar, Derek LeRoith & Peter E. Lobie. (2000) CrkII Participation in the Cellular Effects of Growth Hormone and Insulin-like Growth Factor-1. Journal of Biological Chemistry 275:23, pages 17683-17692.
Crossref
Guido Posern, Rainer Saffrich, Wilhelm Ansorge & Stephan M. Feller. (2000) Rapid lamellipodia formation in nerve growth factor-stimulated PC12 cells is dependent on Rac and PI3K activity. Journal of Cellular Physiology 183:3, pages 416-424.
Crossref
QIONG A. LIU & MICHAEL O. HENGARTNER. (1999) The Molecular Mechanism of Programmed Cell Death in C. elegans . Annals of the New York Academy of Sciences 887:1, pages 92-104.
Crossref
Naoki Uemura & James D. Griffin. (1999) The Adapter Protein Crkl Links Cbl to C3G after Integrin Ligation and Enhances Cell Migration. Journal of Biological Chemistry 274:53, pages 37525-37532.
Crossref
David A. Cheresh, Jie Leng & Richard L. Klemke. (1999) Regulation of Cell Contraction and Membrane Ruffling by Distinct Signals in Migratory Cells. Journal of Cell Biology 146:5, pages 1107-1116.
Crossref
Masanori Okuda, Masafumi Takahashi, James Suero, Charles E. Murry, Oren Traub, Hisaaki Kawakatsu & Bradford C. Berk. (1999) Shear Stress Stimulation of p130 Tyrosine Phosphorylation Requires Calcium-dependent c-Src Activation. Journal of Biological Chemistry 274:38, pages 26803-26809.
Crossref
David E Weinstein, Kostantin Dobrenis & Raymond B Birge. (1999) Targeted expression of an oncogenic adaptor protein v-Crk potentiates axonal growth in dorsal root ganglia and motor neurons in vivo. Developmental Brain Research 116:1, pages 29-39.
Crossref
Jiaqi Huang, Bao-Tong Zhang, Yongqing Li, Bruce Mayer, Kermit L Carraway & Coralie A Carothers Carraway. (1999) c-Src association with and phosphorylation of p58gag, a membrane- and microfilament-associated retroviral Gag-like protein in a xenotransplantable rat mammary tumor. Oncogene 18:28, pages 4099-4107.
Crossref
Sigal Gelkop & Noah Isakov. (1999) T Cell Activation Stimulates the Association of Enzymatically Active Tyrosine-phosphorylated ZAP-70 with the Crk Adapter Proteins. Journal of Biological Chemistry 274:31, pages 21519-21527.
Crossref
Xiang-Qun Chen, Ivan Tan, Thomas Leung & Louis Lim. (1999) The Myotonic Dystrophy Kinase-related Cdc42-binding Kinase Is Involved in the Regulation of Neurite Outgrowth in PC12 Cells. Journal of Biological Chemistry 274:28, pages 19901-19905.
Crossref
Maja Oktay, Kishore K. Wary, Michael Dans, Raymond B. Birge & Filippo G. Giancotti. (1999) Integrin-mediated Activation of Focal Adhesion Kinase Is Required for Signaling to Jun NH2-terminal Kinase and Progression through the G1 Phase of the Cell Cycle. Journal of Cell Biology 145:7, pages 1461-1470.
Crossref
Elena A Feshchenko, Scott K Shore & Alexander Y Tsygankov. (1999) Tyrosine phosphorylation of C-Cbl facilitates adhesion and spreading while suppressing anchorage-independent growth of V-Abl-transformed NIH3T3 fibroblasts. Oncogene 18:25, pages 3703-3715.
Crossref
Naoki Uemura, Ravi Salgia, Darren S Ewaniuk, Marie-Terese Little & James D Griffin. (1999) Involvement of the adapter protein CRKL in integrin-mediated adhesion. Oncogene 18:22, pages 3343-3353.
Crossref
Ayako AraiYurika NosakaHitoshi KohsakaNobuyuki MiyasakaOsamu Miura. (1999) CrkL Activates Integrin-Mediated Hematopoietic Cell Adhesion Through the Guanine Nucleotide Exchange Factor C3G. Blood 93:11, pages 3713-3722.
Crossref
Ayako AraiYurika NosakaHitoshi KohsakaNobuyuki MiyasakaOsamu Miura. (1999) CrkL Activates Integrin-Mediated Hematopoietic Cell Adhesion Through the Guanine Nucleotide Exchange Factor C3G. Blood 93:11, pages 3713-3722.
Crossref
Noriyuki Tsukamoto, Masakazu Hattori, Hailin Yang, Johannes L. Bos & Nagahiro Minato. (1999) Rap1 GTPase-activating Protein SPA-1 Negatively Regulates Cell Adhesion. Journal of Biological Chemistry 274:26, pages 18463-18469.
Crossref
Yoshihisa Nojima. (1999) Structure and function of the p130Cas-related protein family. Japanese Journal of Rheumatology 9:2, pages 123-133.
Crossref
Simone M Schoenwaelder & Keith Burridge. (1999) Bidirectional signaling between the cytoskeleton and integrins. Current Opinion in Cell Biology 11:2, pages 274-286.
Crossref
Miguel Garcia-Guzman, Fabrizio Dolfi, Michael Russello & Kristiina Vuori. (1999) Cell Adhesion Regulates the Interaction between the Docking Protein p130Cas and the 14-3-3 Proteins. Journal of Biological Chemistry 274:9, pages 5762-5768.
Crossref
Naoki Nakashima, David W. Rose, Sen Xiao, Katsuya Egawa, Stuart S. Martin, Tetsuro Haruta, Alan R. Saltiel & Jerrold M. Olefsky. (1999) The Functional Role of CrkII in Actin Cytoskeleton Organization and Mitogenesis. Journal of Biological Chemistry 274:5, pages 3001-3008.
Crossref
Kerstin Andersson, Cathrine Persson & Maria Fällman. 1999. Phagocytosis:Microbial Invasion. Phagocytosis:Microbial Invasion 27 57 .
RaeKil Park, Dong-Hyun Kim, Myung-Sun Kim, Hong-Seob So, Hun-Taeg Chung, Kang-Beom Kwon, Do-Gon Ryu & Bok-Ryang Kim. (1998) Association of Shc, Cbl, Grb2, and Sos Following Treatment with 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Primary Rat Hepatocytes. Biochemical and Biophysical Research Communications 253:3, pages 577-581.
Crossref
Kathrin H. Kirsch, Maria-Magdalena Georgescu & Hidesaburo Hanafusa. (1998) Direct Binding of p130Cas to the Guanine Nucleotide Exchange Factor C3G. Journal of Biological Chemistry 273:40, pages 25673-25679.
Crossref
Joan S Brugge. (1998) Casting light on focal adhesions. Nature Genetics 19:4, pages 309-311.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.