Advanced search
Publication Cover
Molecular and Cellular Biology Volume 18, 1998 - Issue 7
Submit an article Journal homepage
43
Views
214
CrossRef citations to date
0
Altmetric
Transcriptional Regulation

Regulation of Transcription by Hypoxia Requires a Multiprotein Complex That Includes Hypoxia-Inducible Factor 1, an Adjacent Transcription Factor, and p300/CREB Binding Protein

Benjamin L. Eberta Division of Hematology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts02115;b Harvard-MIT Division of Health Sciences and Technology, Cambridge, Massachusetts02139
&
H. Franklin Bunna Division of Hematology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts02115Correspondence[email protected]
Pages 4089-4096 | Received 23 Dec 1997, Accepted 16 Apr 1998, Published online: 28 Mar 2023

Citations (214)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (11)

Zaira Rehman, Ishrat Jabeen, Ammad Fahim, Attya Bhatti & Peter John. (2022) Molecular docking and pharmacophore models to probe binding hypothesis of inhibitors of hypoxia inducible factor-1. Journal of Biomolecular Structure and Dynamics 40:17, pages 7714-7725.
Read now
Najah Albadari, Shanshan Deng & Wei Li. (2019) The transcriptional factors HIF-1 and HIF-2 and their novel inhibitors in cancer therapy. Expert Opinion on Drug Discovery 14:7, pages 667-682.
Read now
Chih-Chung Feng, Chien-Chung Lin, Yi-Ping Lai, Tung-Sheng Chen, Shibu Marthandam Asokan, Jing-Ying Lin, Kuan-Ho Lin, Vijaya Padma Viswanadha, Wei-Wen Kuo & Chih-Yang Huang. (2016) Hypoxia suppresses myocardial survival pathway through HIF-1α-IGFBP-3-dependent signaling and enhances cardiomyocyte autophagic and apoptotic effects mainly via FoxO3a-induced BNIP3 expression. Growth Factors 34:3-4, pages 73-86.
Read now
Veronica L. Dengler, Matthew D. Galbraith & Joaquín M. Espinosa. (2014) Transcriptional regulation by hypoxia inducible factors. Critical Reviews in Biochemistry and Molecular Biology 49:1, pages 1-15.
Read now
Johnny A. Sena, Liyi Wang & Cheng-Jun Hu. (2013) BRG1 and BRM Chromatin-Remodeling Complexes Regulate the Hypoxia Response by Acting as Coactivators for a Subset of Hypoxia-Inducible Transcription Factor Target Genes. Molecular and Cellular Biology 33:19, pages 3849-3863.
Read now
Matthew R. Pawlus, Liyi Wang, Katie Ware & Cheng-Jun Hu. (2012) Upstream Stimulatory Factor 2 and Hypoxia-Inducible Factor 2α (HIF2α) Cooperatively Activate HIF2 Target Genes during Hypoxia. Molecular and Cellular Biology 32:22, pages 4595-4610.
Read now
Qin Yan, Steven Bartz, Mao Mao, Lianjie Li & William G. Kaelin$suffix/text()$suffix/text(). (2007) The Hypoxia-Inducible Factor 2α N-Terminal and C-Terminal Transactivation Domains Cooperate To Promote Renal Tumorigenesis In Vivo. Molecular and Cellular Biology 27:6, pages 2092-2102.
Read now
Cheng-Jun Hu, Li-Yi Wang, Lewis A. Chodosh, Brian Keith & M. Celeste Simon. (2003) Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation. Molecular and Cellular Biology 23:24, pages 9361-9374.
Read now
Lawrence B. Gardner, Feng Li, Xuejie Yang & Chi V. Dang. (2003) Anoxic Fibroblasts Activate a Replication Checkpoint That Is Bypassed By E1a. Molecular and Cellular Biology 23:24, pages 9032-9045.
Read now
Nianli Sang, Jie Fang, Vickram Srinivas, Irene Leshchinsky & Jaime Caro. (2002) Carboxyl-Terminal Transactivation Activity of Hypoxia-Inducible Factor 1α Is Governed by a von Hippel-Lindau Protein-Independent, Hydroxylation-Regulated Association with p300/CBP. Molecular and Cellular Biology 22:9, pages 2984-2992.
Read now
Ryuzo SASAKI, Seiji MASUDA & Masaya NAGAO. (2000) Erythropoietin: Multiple Physiological Functions and Regulation of Biosynthesis. Bioscience, Biotechnology, and Biochemistry 64:9, pages 1775-1793.
Read now

Articles from other publishers (203)

Julia Seva Gomes, Leticia Barros Sene, Gabriela Leme Lamana, Patricia Aline Boer & José Antonio Rocha Gontijo. (2023) Impact of maternal protein restriction on Hypoxia-Inducible Factor (HIF) expression in male fetal kidney development. PLOS ONE 18:5, pages e0266293.
Crossref
Su-Ying Wen, Ayaz Ali, I-Chieh Huang, Jian-Sheng Liu, Po-Yuan Chen, Vijaya Padma Viswanadha, Chih-Yang Huang & Wei-Wen Kuo. (2023) Doxorubicin induced ROS-dependent HIF1α activation mediates blockage of IGF1R survival signaling by IGFBP3 promotes cardiac apoptosis. Aging 15:1, pages 164-178.
Crossref
Yoko Ono & Hidemasa Bono. (2022) Exploratory meta-analysis of hypoxic transcriptomes using a precise transcript reference sequence set. Life Science Alliance 6:1, pages e202201518.
Crossref
Saki Gotoh‐Saito, Daichi Sadato & Futoshi Shibasaki. (2022) INT6 / eIF3e represses E‐cadherin expression through HIF2α in lung carcinoma A549 cells . Genes to Cells 27:12, pages 689-705.
Crossref
Francis D. Appling, Rebecca B. Berlow, Robyn L. Stanfield, H. Jane Dyson & Peter E. Wright. (2021) The molecular basis of allostery in a facilitated dissociation process. Structure 29:12, pages 1327-1338.e5.
Crossref
Sakshi Taneja, Stefan W. Vetter & Estelle Leclerc. (2021) Hypoxia and the Receptor for Advanced Glycation End Products (RAGE) Signaling in Cancer. International Journal of Molecular Sciences 22:15, pages 8153.
Crossref
Caren Weinhouse. (2021) The roles of inducible chromatin and transcriptional memory in cellular defense system responses to redox-active pollutants. Free Radical Biology and Medicine 170, pages 85-108.
Crossref
Jing Zhang, Yaowu Qin, Mireya Martinez, Miguel Flores-Bellver, Murilo Rodrigues, Aumreetam Dinabandhu, Xuan Cao, Monika Deshpande, Yu Qin, Silvia Aparicio-Domingo, Yuan Rui, Stephany Y. Tzeng, Shaima Salman, Jin Yuan, Adrienne W. Scott, Jordan J. Green, M. Valeria Canto-Soler, Gregg L. Semenza, Silvia Montaner & Akrit Sodhi. (2021) HIF-1α and HIF-2α redundantly promote retinal neovascularization in patients with ischemic retinal disease. Journal of Clinical Investigation 131:12.
Crossref
Robert B. A. Quinlan & Paul E. Brennan. (2021) Chemogenomics for drug discovery: clinical molecules from open access chemical probes. RSC Chemical Biology 2:3, pages 759-795.
Crossref
Yoko Ono & Hidemasa Bono. (2021) Multi-Omic Meta-Analysis of Transcriptomes and the Bibliome Uncovers Novel Hypoxia-Inducible Genes. Biomedicines 9:5, pages 582.
Crossref
Agathe L. Chédeville & Patricia A. Madureira. (2021) The Role of Hypoxia in Glioblastoma Radiotherapy Resistance. Cancers 13:3, pages 542.
Crossref
Kelsey G. DeFrates, Daniela Franco, Ellen Heber-Katz & Phillip B. Messersmith. (2021) Unlocking mammalian regeneration through hypoxia inducible factor one alpha signaling. Biomaterials 269, pages 120646.
Crossref
Yu-Che Cheng, Hsin-Yi Chiang, Shang-Jung Cheng, Hung-Wei Chang, Yi-Ju Li & Sheau-Yann Shieh. (2020) Loss of the tumor suppressor BTG3 drives a pro-angiogenic tumor microenvironment through HIF-1 activation. Cell Death & Disease 11:12.
Crossref
Jessica D. Kindrick & David R. Mole. (2020) Hypoxic Regulation of Gene Transcription and Chromatin: Cause and Effect. International Journal of Molecular Sciences 21:21, pages 8320.
Crossref
Mira Kreuzer, Arindam Banerjee, Charles N. Birts, Matthew Darley, Ali Tavassoli, Mircea Ivan & Jeremy P. Blaydes. (2020) Glycolysis, via NADH‐dependent dimerisation of CtBPs, regulates hypoxia‐induced expression of CAIX and stem‐like breast cancer cell survival. FEBS Letters 594:18, pages 2988-3001.
Crossref
Yaxi Yang, Rukang Zhang, Zhaojun Li, Lianghe Mei, Shili Wan, Hong Ding, Zhifeng Chen, Jing Xing, Huijin Feng, Jie Han, Hualiang Jiang, Mingyue Zheng, Cheng Luo & Bing Zhou. (2020) Discovery of Highly Potent, Selective, and Orally Efficacious p300/CBP Histone Acetyltransferases Inhibitors. Journal of Medicinal Chemistry 63:3, pages 1337-1360.
Crossref
Joachim Fandrey, Johannes Schödel, Kai-Uwe Eckardt, Dörthe M. Katschinski & Roland H. Wenger. (2019) Now a Nobel gas: oxygen. Pflügers Archiv - European Journal of Physiology 471:11-12, pages 1343-1358.
Crossref
Mayuko Osada-Oka, Nobuhito Goda, Hiroyuki Saiga, Masahiro Yamamoto, Kiyoshi Takeda, Yuriko Ozeki, Takehiro Yamaguchi, Tomoyoshi Soga, Yu Tateishi, Katsuyuki Miura, Daisuke Okuzaki, Kazuo Kobayashi & Sohkichi Matsumoto. (2019) Metabolic adaptation to glycolysis is a basic defense mechanism of macrophages for Mycobacterium tuberculosis infection . International Immunology 31:12, pages 781-793.
Crossref
Musbau Adewumi Akanji, Damilare Rotimi & Oluyomi Stephen Adeyemi. (2019) Hypoxia-Inducible Factors as an Alternative Source of Treatment Strategy for Cancer. Oxidative Medicine and Cellular Longevity 2019, pages 1-10.
Crossref
Qiong WuWen-Shuang WuLin SuXin ZhengWen-Yue WuPaolo SantambrogioYu-Jing GouQian HaoPei-Na WangYa-Ru LiBao-Lu ZhaoGuangjun NieSonia LeviYan-Zhong Chang. (2019) Mitochondrial Ferritin Is a Hypoxia-Inducible Factor 1α-Inducible Gene That Protects from Hypoxia-Induced Cell Death in Brain. Antioxidants & Redox Signaling 30:2, pages 198-212.
Crossref
Katharina Krueger, Lorenzo Catanese, Lina K. Sciesielski, Karin M. Kirschner & Holger Scholz. (2019) Deletion of an intronic HIF-2α binding site suppresses hypoxia-induced WT1 expression. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1862:1, pages 71-83.
Crossref
Andrea Pagani, Matthias M. Aitzetmüller & Dominik Duscher. 2019. Regenerative Medicine and Plastic Surgery. Regenerative Medicine and Plastic Surgery 201 209 .
Andrea Pagani, Matthias M. Aitzetmüller, Elizabeth A. Brett, Viktoria König, Raphael Wenny, Dominik Thor, Christine Radtke, Georg M. Huemer, Hans-Günther Machens & Dominik Duscher. (2018) Skin Rejuvenation through HIF-1α Modulation. Plastic & Reconstructive Surgery 141:4, pages 600e-607e.
Crossref
Naoyuki Tahara, Ryutaro Akiyama, Joshua W.M. Theisen, Hiroko Kawakami, Julia Wong, Daniel J. Garry & Yasuhiko Kawakami. (2018) Gata6 restricts Isl1 to the posterior of nascent hindlimb buds through Isl1 cis-regulatory modules. Developmental Biology 434:1, pages 74-83.
Crossref
Ana Monteiro, Richard Hill, Geoffrey Pilkington & Patrícia Madureira. (2017) The Role of Hypoxia in Glioblastoma Invasion. Cells 6:4, pages 45.
Crossref
Xiaosai Yao, Jing Tan, Kevin Junliang Lim, Joanna Koh, Wen Fong Ooi, Zhimei Li, Dachuan Huang, Manjie Xing, Yang Sun Chan, James Zhengzhong Qu, Su Ting Tay, Giovani Wijaya, Yue Ning Lam, Jing Han Hong, Ai Ping Lee-Lim, Peiyong Guan, Michelle Shu Wen Ng, Cassandra Zhengxuan He, Joyce Suling Lin, Tannistha Nandi, Aditi Qamra, Chang Xu, Swe Swe Myint, James O. J. Davies, Jian Yuan Goh, Gary Loh, Bryan C. Tan, Steven G. Rozen, Qiang Yu, Iain Bee Huat Tan, Christopher Wai Sam Cheng, Shang Li, Kenneth Tou En Chang, Puay Hoon Tan, David Lawrence Silver, Alexander Lezhava, Gertrud Steger, Jim R. Hughes, Bin Tean Teh & Patrick Tan. (2017) VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma . Cancer Discovery 7:11, pages 1284-1305.
Crossref
Arunoday Bhan, Paromita Deb, Nadine Shihabeddin, Khairul I. Ansari, Marco Brotto & Subhrangsu S. Mandal. (2017) Histone methylase MLL1 coordinates with HIF and regulate lncRNA HOTAIR expression under hypoxia. Gene 629, pages 16-28.
Crossref
Morteza Eskandani, Somayeh Vandghanooni, Jaleh Barar, Hossein Nazemiyeh & Yadollah Omidi. (2017) Cell physiology regulation by hypoxia inducible factor-1: Targeting oxygen-related nanomachineries of hypoxic cells. International Journal of Biological Macromolecules 99, pages 46-62.
Crossref
Ishna N. MistryAli Tavassoli. (2016) Reprogramming the Transcriptional Response to Hypoxia with a Chromosomally Encoded Cyclic Peptide HIF-1 Inhibitor. ACS Synthetic Biology 6:3, pages 518-527.
Crossref
Nikki L. Jernigan, Thomas C. Resta & Laura V. Gonzalez Bosc. 2017. Pulmonary Vasculature Redox Signaling in Health and Disease. Pulmonary Vasculature Redox Signaling in Health and Disease 83 103 .
H. Xia, Z. Gong, Y. Lian, J. Zhou & X. Wang. (2016) Gene Expression Profile Regulated by CREB in K562 Cell Line. Transplantation Proceedings 48:6, pages 2221-2234.
Crossref
Valentina Salvi, William Vermi, Veronica Gianello, Silvia Lonardi, Vincenzo Gagliostro, Antonella Naldini, Silvano Sozzani & Daniela Bosisio. (2016) Dendritic cell-derived VEGF-A plays a role in inflammatory angiogenesis of human secondary lymphoid organs and is driven by the coordinated activation of multiple transcription factors. Oncotarget 7:26, pages 39256-39269.
Crossref
Joel I. Perez-Perri, Veronica L. Dengler, K. Audrey Audetat, Ahwan Pandey, Elizabeth A. Bonner, Marjeta Urh, Jacqui Mendez, Danette L. Daniels, Pablo Wappner, Matthew D. Galbraith & Joaquín M. Espinosa. (2016) The TIP60 Complex Is a Conserved Coactivator of HIF1A. Cell Reports 16:1, pages 37-47.
Crossref
Sarah E. Wilkins, Martine I. Abboud, Rebecca L. Hancock & Christopher J. Schofield. (2016) Targeting Protein-Protein Interactions in the HIF System. ChemMedChem 11:8, pages 773-786.
Crossref
C. Voellenkle, J. M. Garcia-Manteiga, S. Pedrotti, A. Perfetti, I. De Toma, D. Da Silva, B. Maimone, S. Greco, P. Fasanaro, P. Creo, G. Zaccagnini, C. Gaetano & F. Martelli. (2016) Implication of Long noncoding RNAs in the endothelial cell response to hypoxia revealed by RNA-sequencing. Scientific Reports 6:1.
Crossref
Stéphanie Anaís Castaldo, Joana Raquel Freitas, Nadine Vasconcelos Conchinha & Patrícia Alexandra Madureira. (2016) The Tumorigenic Roles of the Cellular REDOX Regulatory Systems. Oxidative Medicine and Cellular Longevity 2016, pages 1-17.
Crossref
Zarifeh Heidary, Jafar Ghaisari, Shiva Moein, Mahmood Naderi & Yousof Gheisari. (2016) Stochastic Petri Net Modeling of Hypoxia Pathway Predicts a Novel Incoherent Feed-Forward Loop Controlling SDF-1 Expression in Acute Kidney Injury. IEEE Transactions on NanoBioscience 15:1, pages 19-26.
Crossref
Yue Wu, Nan Wang, Yonghua Lei, Tianhan Hu, Qidong You & Xiaojin Zhang. (2016) Small-molecule inhibitors of HIF-PHD2: a valid strategy to renal anemia treatment in clinical therapy. MedChemComm 7:7, pages 1271-1284.
Crossref
Scott F. Leiser, Hillary A. Miller & Matt Kaeberlein. 2016. Handbook of the Biology of Aging. Handbook of the Biology of Aging 133 159 .
Alexandra Schörg, Sara Santambrogio, James L. Platt, Johannes Schödel, Maja T. Lindenmeyer, Clemens D. Cohen, Katrin Schrödter, David R. Mole, Roland H. Wenger & David Hoogewijs. (2015) Destruction of a distal hypoxia response element abolishes trans -activation of the PAG1 gene mediated by HIF-independent chromatin looping . Nucleic Acids Research 43:12, pages 5810-5823.
Crossref
Iu.V. Hoshovs’ka Iu.V. Hoshovs’ka. (2015) THE ROLE OF UNCOUPLING PROTEINS IN MECHANISMS OF PROTECTION FROM OXIDATIVE STRESS. Fiziolohichnyĭ zhurnal 61:1, pages 91-101.
Crossref
I. N. Mistry, P. J. S. Smith, D. I. Wilson & A. Tavassoli. (2015) Probing the epigenetic regulation of HIF-1α transcription in developing tissue. Molecular BioSystems 11:10, pages 2780-2785.
Crossref
Tamara Bhandari & Victor Nizet. (2014) Hypoxia-Inducible Factor (HIF) as a Pharmacological Target for Prevention and Treatment of Infectious Diseases. Infectious Diseases and Therapy 3:2, pages 159-174.
Crossref
Mengjie Tang, Yihao Tian, Doulin Li, Jiawei Lv, Qun Li, Changchun Kuang, Pengchao Hu, Ying Wang, Jing Wang, Ke Su & Lei Wei. (2014) TNF-α Mediated Increase of HIF-1α Inhibits VASP Expression, Which Reduces Alveolar-Capillary Barrier Function during Acute Lung Injury (ALI). PLoS ONE 9:7, pages e102967.
Crossref
Duncan A. HayOleg FedorovSarah MartinDean C. SingletonCynthia TallantChristopher WellsSarah PicaudMartin PhilpottOctovia P. MonteiroCatherine M. RogersStuart J. ConwayTimothy P. C. RooneyAnthony TumberClarence YappPanagis FilippakopoulosMark E. Bunnage, Susanne MüllerStefan KnappChristopher J. SchofieldPaul E. Brennan. (2014) Discovery and Optimization of Small-Molecule Ligands for the CBP/p300 Bromodomains. Journal of the American Chemical Society 136:26, pages 9308-9319.
Crossref
Yuanyuan Zhang, Li Wang, Soumyadeep Dey, Mawadda Alnaeeli, Sukanya Suresh, Heather Rogers, Ruifeng Teng & Constance Noguchi. (2014) Erythropoietin Action in Stress Response, Tissue Maintenance and Metabolism. International Journal of Molecular Sciences 15:6, pages 10296-10333.
Crossref
M R Pawlus, L Wang & C-J Hu. (2013) STAT3 and HIF1α cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells. Oncogene 33:13, pages 1670-1679.
Crossref
José Merino, César Roncero, María Oset-Gasque, Ahmad Naddaf & María González. (2014) Antioxidant and Protective Mechanisms against Hypoxia and Hypoglycaemia in Cortical Neurons in Vitro. International Journal of Molecular Sciences 15:2, pages 2475-2493.
Crossref
Lili Li, Katherine Howell, Michelle Sands, Mark Banahan, Stephen Frohlich, Simon C. Rowan, Roisín Neary, Donal Ryan & Paul McLoughlin. (2013) The α and Δ Isoforms of CREB1 Are Required to Maintain Normal Pulmonary Vascular Resistance. PLoS ONE 8:12, pages e80637.
Crossref
Miguel AS Cavadas, Lan K Nguyen & Alex Cheong. (2013) Hypoxia-inducible factor (HIF) network: insights from mathematical models. Cell Communication and Signaling 11:1.
Crossref
Norah-Faye Matthies, Aillette Mulet-Sierra, Nadr M. Jomha & Adetola B. Adesida. (2013) Matrix formation is enhanced in co-cultures of human meniscus cells with bone marrow stromal cells. Journal of Tissue Engineering and Regenerative Medicine 7:12, pages 965-973.
Crossref
RYUJI IKEDA, SHO TABATA, YUSUKE TAJITSU, YUKIHIKO NISHIZAWA, KENTARO MINAMI, TATSUHIKO FURUKAWA, MASATATSU YAMAMOTO, YOSHINARI SHINSATO, SHIN-ICHI AKIYAMA, KATSUSHI YAMADA & YASUO TAKEDA. (2013) Molecular basis for the regulation of hypoxia-inducible factor-1α levels by 2-deoxy-D-ribose. Oncology Reports 30:3, pages 1444-1448.
Crossref
Matthew R. Pawlus & Cheng-Jun Hu. (2013) Enhanceosomes as integrators of hypoxia inducible factor (HIF) and other transcription factors in the hypoxic transcriptional response. Cellular Signalling 25:9, pages 1895-1903.
Crossref
Juraj Adamik, Kent Z. Q. Wang, Sebnem Unlu, An-Jey A. Su, Gillian M. Tannahill, Deborah L. Galson, Luke A. O’Neill & Philip E. Auron. (2013) Distinct Mechanisms for Induction and Tolerance Regulate the Immediate Early Genes Encoding Interleukin 1β and Tumor Necrosis Factor α. PLoS ONE 8:8, pages e70622.
Crossref
Elena Miranda, Ida K. Nordgren, Abigail L. Male, Charlotte E. Lawrence, Franciane Hoakwie, Francesco Cuda, William Court, Keith R. Fox, Paul A. Townsend, Graham K. Packham, Suzanne A. Eccles & Ali Tavassoli. (2013) A Cyclic Peptide Inhibitor of HIF-1 Heterodimerization That Inhibits Hypoxia Signaling in Cancer Cells. Journal of the American Chemical Society 135:28, pages 10418-10425.
Crossref
Kirsten Hogg, John D. Blair, Peter von Dadelszen & Wendy P. Robinson. (2013) Hypomethylation of the LEP gene in placenta and elevated maternal leptin concentration in early onset pre-eclampsia. Molecular and Cellular Endocrinology 367:1-2, pages 64-73.
Crossref
Lan K. Nguyen, Miguel A. S. Cavadas, Carsten C. Scholz, Susan F. Fitzpatrick, Ulrike Bruning, Eoin P. Cummins, Murtaza M. Tambuwala, Mario C. Manresa, Boris N. Kholodenko, Cormac T. Taylor & Alex Cheong. (2013) A dynamic model of the hypoxia-inducible factor 1-alpha (HIF-1α) network. Journal of Cell Science.
Crossref
Claudia Cerella, Flavia Radogna, Mario Dicato & Marc Diederich. (2013) Natural Compounds as Regulators of the Cancer Cell Metabolism. International Journal of Cell Biology 2013, pages 1-16.
Crossref
Ying Wang, Jie Yang, Kai Yang, Hui Cang, Xin-zhi Huang, Hui Li & Jing Yi. (2012) The biphasic redox sensing of SENP3 accounts for the HIF-1 transcriptional activity shift by oxidative stress. Acta Pharmacologica Sinica 33:7, pages 953-963.
Crossref
Irene Abreu-Rodríguez, Rocío Sánchez Silva, Ana Paula Martins, Graça Soveral, Juan José Toledo-Aral, José López-Barneo & Miriam Echevarría. (2011) Functional and Transcriptional Induction of Aquaporin-1 Gene by Hypoxia; Analysis of Promoter and Role of Hif-1α. PLoS ONE 6:12, pages e28385.
Crossref
Alex C. Liao, Chien-Feng Li, Kun-Hung Shen, Lan-Hsiang Chien, Hsuan-Ying Huang & Ting-Feng Wu. (2011) Loss of lactate dehydrogenase B subunit expression is correlated with tumour progression and independently predicts inferior disease-specific survival in urinary bladder urothelial carcinoma. Pathology 43:7, pages 707-712.
Crossref
Yuxing ZhangYanzhi DuWeidong LeKankan WangNelly KiefferJi Zhang. (2011) Redox Control of the Survival of Healthy and Diseased Cells. Antioxidants & Redox Signaling 15:11, pages 2867-2908.
Crossref
Roland H. Wenger & Armin Kurtz. 2011. Comprehensive Physiology. Comprehensive Physiology 1759 1794 .
Joel I. Perez-Perri, Julieta M. Acevedo & Pablo Wappner. (2011) Epigenetics: New Questions on the Response to Hypoxia. International Journal of Molecular Sciences 12:7, pages 4705-4721.
Crossref
Justin I. Tang, Jonathan R. Seckl & Moffat J. Nyirenda. (2011) Prenatal Glucocorticoid Overexposure Causes Permanent Increases in Renal Erythropoietin Expression and Red Blood Cell Mass in the Rat Offspring. Endocrinology 152:7, pages 2716-2721.
Crossref
Katarína Smolková, Lydie Plecitá-Hlavatá, Nadége Bellance, Giovanni Benard, Rodrigue Rossignol & Petr Ježek. (2011) Waves of gene regulation suppress and then restore oxidative phosphorylation in cancer cells. The International Journal of Biochemistry & Cell Biology 43:7, pages 950-968.
Crossref
Yousuf O. Ali, Ryan McCormack, Andrew Darr & R. Grace Zhai. (2011) Nicotinamide Mononucleotide Adenylyltransferase Is a Stress Response Protein Regulated by the Heat Shock Factor/Hypoxia-inducible Factor 1α Pathway. Journal of Biological Chemistry 286:21, pages 19089-19099.
Crossref
Mi-Kyung Oh, Hyo-Jung Park, Nam-Hoon Kim, Seon-Joo Park, In-Yang Park & In-Sook Kim. (2011) Hypoxia-inducible Factor-1α Enhances Haptoglobin Gene Expression by Improving Binding of STAT3 to the Promoter. Journal of Biological Chemistry 286:11, pages 8857-8865.
Crossref
Mark N. Gillespie, Viktor M. Pastukh & Mykhaylo V. Ruchko. (2010) Controlled DNA “damage” and repair in hypoxic signaling. Respiratory Physiology & Neurobiology 174:3, pages 244-251.
Crossref
Kiros Hailemariam, Kenta Iwasaki, Bo-Wen Huang, Kensuke Sakamoto & Yoshiaki Tsuji. (2010) Transcriptional regulation of ferritin and antioxidant genes by HIPK2 under genotoxic stress. Journal of Cell Science 123:22, pages 3863-3871.
Crossref
Christoph UferChi Chiu WangAstrid BorchertDagmar HeydeckHartmut Kuhn. (2010) Redox Control in Mammalian Embryo Development. Antioxidants & Redox Signaling 13:6, pages 833-875.
Crossref
Feng Wang, Ruixue Zhang, Xiaomeng Wu & Oliver Hankinson. (2010) Roles of Coactivators in Hypoxic Induction of the Erythropoietin Gene. PLoS ONE 5:4, pages e10002.
Crossref
Zakary L. WhichardCasim A. SarkarMarek Kimmel & Seth J. Corey. (2010) Hematopoiesis and its disorders: a systems biology approach. Blood 115:12, pages 2339-2347.
Crossref
E. B. Anokhina & L. B. Buravkova. (2010) Mechanisms of regulation of transcription factor HIF under hypoxia. Biochemistry (Moscow) 75:2, pages 151-158.
Crossref
Yueh-Hsuan Chan, Ming-Feng Chiang, Yueh-Chiao Tsai, Shin-Tang Su, Ming-Hsu Chen, Mau-Sheng Hou & Kuo-I Lin. (2009) Absence of the Transcriptional Repressor Blimp-1 in Hematopoietic Lineages Reveals Its Role in Dendritic Cell Homeostatic Development and Function. The Journal of Immunology 183:11, pages 7039-7046.
Crossref
Catherine E. Charron, Pai-Chien Chou, David J.C. Coutts, Vaibhav Kumar, Masako To, Kenichi Akashi, Liao Pinhu, Mark Griffiths, Ian M. Adcock, Peter J. Barnes & Kazuhiro Ito. (2009) Hypoxia-inducible Factor 1α Induces Corticosteroid-insensitive Inflammation via Reduction of Histone Deacetylase-2 Transcription. Journal of Biological Chemistry 284:52, pages 36047-36054.
Crossref
R.M. Gobble, K.A. Groesch, M. Chang, R.J. Torry & D.S. Torry. (2009) Differential Regulation of Human PlGF Gene Expression in Trophoblast and Nontrophoblast Cells by Oxygen Tension. Placenta 30:10, pages 869-875.
Crossref
Chao Huang, Yan Han, Yumei Wang, Xuxu Sun, Shan Yan, Edward T H Yeh, Yuying Chen, Hui Cang, Hui Li, Guiying Shi, Jinke Cheng, Xueming Tang & Jing Yi. (2009) SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation. The EMBO Journal 28:18, pages 2748-2762.
Crossref
Armina A. Kazi, Kristin Happ Molitoris & Robert D. Koos. (2009) Estrogen Rapidly Activates the PI3K/AKT Pathway and Hypoxia-Inducible Factor 1 and Induces Vascular Endothelial Growth Factor A Expression in Luminal Epithelial Cells of the Rat Uterus1. Biology of Reproduction 81:2, pages 378-387.
Crossref
D Mahalingam, R Swords, J S Carew, S T Nawrocki, K Bhalla & F J Giles. (2009) Targeting HSP90 for cancer therapy. British Journal of Cancer 100:10, pages 1523-1529.
Crossref
Wonchung Lim, Jungyoon Cho, Hyeok-yi Kwon, Yeomyeong Park, Mee-Ra Rhyu & YoungJoo Lee. (2009) Hypoxia-inducible factor 1α activates and is inhibited by unoccupied estrogen receptor β. FEBS Letters 583:8, pages 1314-1318.
Crossref
C.A. Stein, SiJian Wu, Anatoliy M. Voskresenskiy, Jin-Feng Zhou, Joongho Shin, Paul Miller, Naira Souleimanian & Luba Benimetskaya. (2009) G3139, an Anti-Bcl-2 Antisense Oligomer That Binds Heparin-Binding Growth Factors and Collagen I, Alters In vitro Endothelial Cell Growth and Tubular Morphogenesis . Clinical Cancer Research 15:8, pages 2797-2807.
Crossref
Ryuta Ishimura, Takashige Kawakami, Seiichiroh Ohsako & Chiharu Tohyama. (2009) Dioxin-induced toxicity on vascular remodeling of the placenta. Biochemical Pharmacology 77:4, pages 660-669.
Crossref
Michael I. Koukourakis, Alexandra Giatromanolaki & Efthimios Sivridis. 2009. Colorectal Cancer. Colorectal Cancer 241 253 .
Xuejun Jin, Hong Ri Jin, Dongho Lee, Jeong-Hyung Lee, Sang Kyum Kim & Jung Joon Lee. (2008) A quassinoid 6α-tigloyloxychaparrinone inhibits hypoxia-inducible factor-1 pathway by inhibition of eukaryotic translation initiation factor 4E phosphorylation. European Journal of Pharmacology 592:1-3, pages 41-47.
Crossref
Zhongping Lu & Michael N. Sack. (2008) ATF-1 Is a Hypoxia-responsive Transcriptional Activator of Skeletal Muscle Mitochondrial-uncoupling Protein 3. Journal of Biological Chemistry 283:34, pages 23410-23418.
Crossref
Viviana Bartella, Sandra Cascio, Elena Fiorio, Alessandra Auriemma, Antonio Russo & Eva Surmacz. (2008) Insulin-Dependent Leptin Expression in Breast Cancer Cells. Cancer Research 68:12, pages 4919-4927.
Crossref
Stefan Kaluz, Milota Kaluzová & Eric J. Stanbridge. (2008) Rational design of minimal hypoxia-inducible enhancers. Biochemical and Biophysical Research Communications 370:4, pages 613-618.
Crossref
Tadhg P. BegleyFlashman Emily, Loenarz Christoph & Christopher J. Schofield. 2007. Wiley Encyclopedia of Chemical Biology. Wiley Encyclopedia of Chemical Biology 1 15 .
Miao Chang, Debashree Mukherjea, Ryan M. Gobble, Kathleen A. Groesch, Ronald J. Torry & Donald S. Torry. (2008) Glial Cell Missing 1 Regulates Placental Growth Factor (PGF) Gene Transcription in Human Trophoblast1. Biology of Reproduction 78:5, pages 841-851.
Crossref
T Klimova & N S Chandel. (2008) Mitochondrial complex III regulates hypoxic activation of HIF. Cell Death & Differentiation 15:4, pages 660-666.
Crossref
S Cascio, V Bartella, A Auriemma, G J Johannes, A Russo, A Giordano & E Surmacz. (2007) Mechanism of leptin expression in breast cancer cells: role of hypoxia-inducible factor-1α. Oncogene 27:4, pages 540-547.
Crossref
Jeffrey F. Breit, Katheryn Ault‐Ziel, Abu‐Bakr Al‐Mehdi & Mark N. Gillespie. (2007) Nuclear protein‐induced bending and flexing of the hypoxic response element of the rat vascular endothelial growth factor promoter. The FASEB Journal 22:1, pages 19-29.
Crossref
Shelley X. L. Zhang, Tina R. Searcy, Yiman Wu, David Gozal & Yang Wang. (2007) Alternative promoter usage and alternative splicing contribute to mRNA heterogeneity of mouse monocarboxylate transporter 2. Physiological Genomics 32:1, pages 95-104.
Crossref
Ye V. Liu, Maimon E. Hubbi, Fan Pan, Karin R. McDonald, Malini Mansharamani, Robert N. Cole, Jun O. Liu & Gregg L. Semenza. (2007) Calcineurin Promotes Hypoxia-inducible Factor 1α Expression by Dephosphorylating RACK1 and Blocking RACK1 Dimerization. Journal of Biological Chemistry 282:51, pages 37064-37073.
Crossref
Viktor Pastukh, Mykhaylo Ruchko, Olena Gorodnya, Glenn L. Wilson & Mark N. Gillespie. (2007) Sequence-specific oxidative base modifications in hypoxia-inducible genes. Free Radical Biology and Medicine 43:12, pages 1616-1626.
Crossref
Md Nasimuzzaman, Gulam Waris, David Mikolon, Dwayne G. Stupack & Aleem Siddiqui. (2007) Hepatitis C Virus Stabilizes Hypoxia-Inducible Factor 1α and Stimulates the Synthesis of Vascular Endothelial Growth Factor. Journal of Virology 81:19, pages 10249-10257.
Crossref
Túlio César Ferreira, Libi Hertzberg, Max Gassmann & Élida Geralda Campos. (2007) The yeast genome may harbor hypoxia response elements (HRE). Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 146:1-2, pages 255-263.
Crossref
Min Liu, Dengwen Li, Ritu Aneja, Harish C. Joshi, Songbo Xie, Chao Zhang & Jun Zhou. (2007) PO2-dependent Differential Regulation of Multidrug Resistance 1 Gene Expression by the c-Jun NH2-terminal Kinase Pathway. Journal of Biological Chemistry 282:24, pages 17581-17586.
Crossref
Amber Buescher Johnson & Michelle Craig Barton. (2007) Hypoxia-induced and stress-specific changes in chromatin structure and function. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 618:1-2, pages 149-162.
Crossref
Hyun-Jun Kim, Heekyoung Chung, Young-Gun Yoo, Hwan Kim, Jeong-Yeon Lee, Mi-Ock Lee & Gu Kong. (2007) Inhibitor of DNA Binding 1 Activates Vascular Endothelial Growth Factor through Enhancing the Stability and Activity of Hypoxia-Inducible Factor-1α. Molecular Cancer Research 5:4, pages 321-329.
Crossref
Karen A. Vincent & Ralph A. Kelly. 2007. Therapeutic Neovascularization–Quo Vadis?. Therapeutic Neovascularization–Quo Vadis? 123 137 .
Qingdong Ke & Max Costa. (2006) Hypoxia-Inducible Factor-1 (HIF-1). Molecular Pharmacology 70:5, pages 1469-1480.
Crossref
Fanxia ShenHua SuYongfeng FanYongmei ChenYiqian ZhuWeizhong LiuWilliam L. YoungGuo-Yuan Yang. (2006) Adeno-Associated Viral Vector-Mediated Hypoxia-Inducible Vascular Endothelial Growth Factor Gene Expression Attenuates Ischemic Brain Injury After Focal Cerebral Ischemia in Mice. Stroke 37:10, pages 2601-2606.
Crossref
Robert D. Guzy & Paul T. Schumacker. (2006) Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia. Experimental Physiology 91:5, pages 807-819.
Crossref
B. Mazurek, C. Rheinländer, F.-U. Fuchs, N. Amarjargal, R.-J. Kuban, U. Ungethüm, H. Haupt, T. Kietzmann & J. Gross. (2006) Einfluss von Ischämie/Hypoxie auf die HIF-1-Aktivität und Expression von hypoxieabhängigen Genen in der Kochlea der neugeborenen RatteInfluence of ischemia/hypoxia on the HIF-1 activity and expression of hypoxia-dependent genes in the cochlea of the newborn rat. HNO 54:9, pages 689-697.
Crossref
Ming-Xiong Guo, Di Wang, Huan-Jie Shao, Hong-Ling Qiu, Lu Xue, Zhou-Zhou Zhao, Chen-Gang Zhu, Yun-Bo Shi & Wen-Xin Li. (2006) Transcription of Human Zinc Finger ZNF268 Gene Requires an Intragenic Promoter Element. Journal of Biological Chemistry 281:34, pages 24623-24636.
Crossref
Yuxia Luo, Canwen Jiang, Adam J. Belanger, Geoffrey Y. Akita, Samuel C. Wadsworth, Richard J. Gregory & Karen A. Vincent. (2006) A Constitutively Active Hypoxia-Inducible Factor-1α/VP16 Hybrid Factor Activates Expression of the Human B-Type Natriuretic Peptide Gene. Molecular Pharmacology 69:6, pages 1953-1962.
Crossref
Eva GottfriedLeoni A. Kunz-SchughartStephanie EbnerWolfgang Mueller-KlieserSabine HovesReinhard AndreesenAndreas MackensenMarina Kreutz. (2006) Tumor-derived lactic acid modulates dendritic cell activation and antigen expression. Blood 107:5, pages 2013-2021.
Crossref
Thomas A. Gorr, Cynthia V. Rider, Helen Y. Wang, Allen W. Olmstead & Gerald A. LeBlanc. (2006) A candidate juvenoid hormone receptor cis-element in the Daphnia magna hb2 hemoglobin gene promoter. Molecular and Cellular Endocrinology 247:1-2, pages 91-102.
Crossref
Michele M. Hickey & M. Celeste Simon. 2006. 217 257 .
Graham Molineux. 2006. Erythropoietins and Erythropoiesis. Erythropoietins and Erythropoiesis 113 132 .
Roland H. WengerDaniel P. StiehlGieri Camenisch. (2005) Integration of Oxygen Signaling at the Consensus HRE. Science's STKE 2005:306.
Crossref
Yonghua Zhu, David T Denhardt, Hongbin Cao, Patrick D Sutphin, Albert C Koong, Amato J Giaccia & Quynh-Thu Le. (2005) Hypoxia upregulates osteopontin expression in NIH-3T3 cells via a Ras-activated enhancer. Oncogene 24:43, pages 6555-6563.
Crossref
Adriana Zakrzewska, Phillip O. Schnell, Justin B. Striet, Anna Hui, Jennifer R. Robbins, Milan Petrovic, Laura Conforti, David Gozal, Marc G. Wathelet & Maria F. Czyzyk-Krzeska. (2005) Hypoxia-activated metabolic pathway stimulates phosphorylation of p300 and CBP in oxygen-sensitive cells. Journal of Neurochemistry 94:5, pages 1288-1296.
Crossref
Joo Eun Jung, Hyun‐Gyu Lee, Ik‐Hyun Cho, Doo Hyun Chung, Sun‐Hee Yoon, Young Mok Yang, Jung Weon Lee, Seongwon Choi, Jong‐Wan Park, Sang‐Kyu Ye & Myung‐Hee Chung. (2005) STAT3 is a potential modulator of HIF‐1‐mediated VEGF expression in human renal carcinoma cells. The FASEB Journal 19:10, pages 1296-1298.
Crossref
Seok Joon Kwon & Yong J. Lee. (2005) Effect of Low Glutamine/Glucose on Hypoxia-Induced Elevation of Hypoxia-Inducible Factor-1α in Human Pancreatic Cancer MiaPaCa-2 and Human Prostatic Cancer DU-145 Cells. Clinical Cancer Research 11:13, pages 4694-4700.
Crossref
Julia I. Bárdos & Margaret Ashcroft. (2005) Negative and positive regulation of HIF-1: A complex network. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1755:2, pages 107-120.
Crossref
Noan-Minh Chau, Paul Rogers, Wynne Aherne, Veronica Carroll, Ian Collins, Edward McDonald, Paul Workman & Margaret Ashcroft. (2005) Identification of Novel Small Molecule Inhibitors of Hypoxia-Inducible Factor-1 That Differentially Block Hypoxia-Inducible Factor-1 Activity and Hypoxia-Inducible Factor-1α Induction in Response to Hypoxic Stress and Growth Factors. Cancer Research 65:11, pages 4918-4928.
Crossref
Thomas Hellwig-BürgelDaniel P. StiehlAnika E. WagnerEric MetzenWolfgang Jelkmann. (2005) Review: Hypoxia-Inducible Factor-1 (HIF-1): A Novel Transcription Factor in Immune Reactions . Journal of Interferon & Cytokine Research 25:6, pages 297-310.
Crossref
Véronique Carrière, Maude Le Gall, Florence Gouyon-Saumande, Dieter Schmoll, Edith Brot-Laroche, Valérie Chauffeton, Jean Chambaz & Monique Rousset. (2005) Intestinal Glucose-dependent Expression of Glucose-6-phosphatase. Journal of Biological Chemistry 280:20, pages 20094-20101.
Crossref
Michael J Gray, Jing Zhang, Lee M Ellis, Gregg L Semenza, Douglas B Evans, Stephanie S Watowich & Gary E Gallick. (2005) HIF-1α, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas. Oncogene 24:19, pages 3110-3120.
Crossref
Cameron P. Bracken, Murray L. Whitelaw & Daniel J. Peet. (2005) Activity of Hypoxia-inducible Factor 2α Is Regulated by Association with the NF-κB Essential Modulator. Journal of Biological Chemistry 280:14, pages 14240-14251.
Crossref
Kathryn A. Ziel, Valentina Grishko, Clayton C. Campbell, Jeffrey F. Breit, Glenn L. Wilson & Mark N. Gillespie. (2005) Oxidants in signal transduction: impact on DNA integrity and gene expression. The FASEB Journal 19:3, pages 387-394.
Crossref
Jorge L. Ruas, Lorenz Poellinger & Teresa Pereira. (2005) Role of CBP in regulating HIF-1-mediated activation of transcription. Journal of Cell Science 118:2, pages 301-311.
Crossref
Johann Gross. 2005. Molekularmedizinische Grundlagen von fetalen und neonatalen Erkrankungen. Molekularmedizinische Grundlagen von fetalen und neonatalen Erkrankungen 573 605 .
Feng Wang, Ruixue Zhang, Timothy V. Beischlag, Christian Muchardt, Moshe Yaniv & Oliver Hankinson. (2004) Roles of Brahma and Brahma/SWI2-Related Gene 1 in Hypoxic Induction of the Erythropoietin Gene. Journal of Biological Chemistry 279:45, pages 46733-46741.
Crossref
Thomas A. Gorr, Joshua D. Cahn, Hideo Yamagata & H. Franklin Bunn. (2004) Hypoxia-induced Synthesis of Hemoglobin in the Crustacean Daphnia magna Is Hypoxia-inducible Factor-dependent. Journal of Biological Chemistry 279:34, pages 36038-36047.
Crossref
Harshini Mukundan, Nancy L. Kanagy & Thomas C. Resta. (2004) 17-β Estradiol Attenuates Hypoxic Induction of HIF-1α and Erythropoietin in Hep3B Cells. Journal of Cardiovascular Pharmacology 44:1, pages 93-100.
Crossref
Kathryn A. Ziel, Clayton C. Campbell, Glenn L. Wilson & Mark N. Gillespie. (2004) Ref‐1/Ape is critical for formation of the hypoxia‐inducible transcriptional complex on the hypoxic response element of the rat pulmonary artery endothelial cell VEGF gene. The FASEB Journal 18:9, pages 986-988.
Crossref
Olga Aprelikova, Gadisetti V.R. Chandramouli, Matthew Wood, James R. Vasselli, Joseph Riss, Jodi K. Maranchie, W. Marston Linehan & J. Carl Barrett. (2004) Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors. Journal of Cellular Biochemistry 92:3, pages 491-501.
Crossref
Hena Alam, Evelyn T. Maizels, Youngkyu Park, Shail Ghaey, Zachary J. Feiger, Navdeep S. Chandel & Mary Hunzicker-Dunn. (2004) Follicle-stimulating Hormone Activation of Hypoxia-inducible Factor-1 by the Phosphatidylinositol 3-Kinase/AKT/Ras Homolog Enriched in Brain (Rheb)/Mammalian Target of Rapamycin (mTOR) Pathway Is Necessary for Induction of Select Protein Markers of Follicular Differentiation. Journal of Biological Chemistry 279:19, pages 19431-19440.
Crossref
Gisele Höpfl, Omolara Ogunshola & Max Gassmann. (2004) HIFs and tumors—causes and consequences. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 286:4, pages R608-R623.
Crossref
Naoki Miki, Megumi Ikuta & Takashi Matsui. (2004) Hypoxia-induced Activation of the Retinoic Acid Receptor-related Orphan Receptor α4 Gene by an Interaction between Hypoxia-inducible Factor-1 and Sp1. Journal of Biological Chemistry 279:15, pages 15025-15031.
Crossref
Tilman Sánchez-Elsner, Jose R. Ramı́rez, Francisco Rodriguez-Sanz, Elisa Varela, Carmelo Bernabéu & Luisa M. Botella. (2004) A Cross-Talk Between Hypoxia and TGF-β Orchestrates Erythropoietin Gene Regulation Through SP1 and Smads. Journal of Molecular Biology 336:1, pages 9-24.
Crossref
U. Berchner-Pfannschmidt, C. Wotzlaw, E. Merten, H. Acker & J. Fandrey. (2004) Visualization of the three-dimensional organization of hypoxia-inducible factor-1α and interacting cofactors in subnuclear structures. Biological Chemistry 385:3-4.
Crossref
Ji-Woong Choi, Sang Chul Park, Gyeong Hoon Kang, Jun O. Liu & Hong-Duk Youn. (2004) Nur77 Activated by Hypoxia-Inducible Factor-1α Overproduces Proopiomelanocortin in von Hippel-Lindau-Mutated Renal Cell Carcinoma. Cancer Research 64:1, pages 35-39.
Crossref
Christof Dame, Martha C. Sola, Kim-Chew Lim, Kelly M. Leach, Joachim Fandrey, Yaluan Ma, Gisela Knöpfle, James Douglas Engel & Jörg Bungert. (2004) Hepatic Erythropoietin Gene Regulation by GATA-4. Journal of Biological Chemistry 279:4, pages 2955-2961.
Crossref
Ulrike Roth, Katja Curth, Terry G. Unterman & Thomas Kietzmann. (2004) The Transcription Factors HIF-1 and HNF-4 and the Coactivator p300 Are Involved in Insulin-regulated Glucokinase Gene Expression via the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway. Journal of Biological Chemistry 279:4, pages 2623-2631.
Crossref
Kelly L. Covello & M.Celeste Simon. 2004. Developmental Vascular Biology. Developmental Vascular Biology 37 54 .
Fiona A. Mack & M. Celeste Simon. 2004. Handbook of Stem Cells. Handbook of Stem Cells 91 100 .
Agnes Görlach, Helmut Acker & Thomas Kietzmann. 2004. Hypoxic Pulmonary Vasoconstriction. Hypoxic Pulmonary Vasoconstriction 341 360 .
J�rg H. W. Distler, Roland H. Wenger, Max Gassmann, Mariola Kurowska, Astrid Hirth, Steffen Gay & Oliver Distler. (2004) Physiologic responses to hypoxia and implications for hypoxia-inducible factors in the pathogenesis of rheumatoid arthritis. Arthritis & Rheumatism 50:1, pages 10-23.
Crossref
M I Koukourakis, A Giatromanolaki, E Sivridis, G Bougioukas, V Didilis, K C Gatter & A L Harris. (2003) Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis. British Journal of Cancer 89:5, pages 877-885.
Crossref
Johann Gross, Cornelia Rheinländer, Julia Fuchs, Birgit Mazurek, Astrid Machulik, Nadezhda Andreeva & T. Kietzmann. (2003) Expression of hypoxia-inducible factor-1 in the cochlea of newborn rats. Hearing Research 183:1-2, pages 73-83.
Crossref
Tsunenori Kodama, Noriaki Shimizu, Noritada Yoshikawa, Yuichi Makino, Rika Ouchida, Kensaku Okamoto, Tetsuya Hisada, Hiroshi Nakamura, Chikao Morimoto & Hirotoshi Tanaka. (2003) Role of the Glucocorticoid Receptor for Regulation of Hypoxia-dependent Gene Expression. Journal of Biological Chemistry 278:35, pages 33384-33391.
Crossref
L. Eric Huang & H. Franklin Bunn. (2003) Hypoxia-inducible Factor and Its Biomedical Relevance. Journal of Biological Chemistry 278:22, pages 19575-19578.
Crossref
Aaron Barchowsky & Kimberley A. O’Hara. (2003) Metal-induced cell signaling and gene activation in lung diseases. Free Radical Biology and Medicine 34:9, pages 1130-1135.
Crossref
Hong ZhangHasan O. AkmanEric L. P. SmithJin ZhaoJoanne E. Murphy-UllrichOlcay A. Batuman. (2003) Cellular response to hypoxia involves signaling via Smad proteins. Blood 101:6, pages 2253-2260.
Crossref
Yohko Yamazaki, Kiyoshi Egawa, Kiyoshi Nose, Setsuko Kunimoto & Tomio Takeuchi. (2003) HIF-1-Dependent VEGF Reporter Gene Assay by a Stable Transformant of CHO Cells.. Biological and Pharmaceutical Bulletin 26:4, pages 417-420.
Crossref
Fiona A Mack, W.Kimryn Rathmell, Andrew M Arsham, James Gnarra, Brian Keith & M.Celeste Simon. (2003) Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth. Cancer Cell 3:1, pages 75-88.
Crossref
Gisele Höpfl, Omolara Ogunshola & Max Gassmann. 2003. Hypoxia. Hypoxia 89 115 .
Leszek Kubin, David Gozal & Maria Czyzyk-Krzeska. 2002. Sleep-Related Breathing Disorders. Sleep-Related Breathing Disorders.
Kazuko Miyazaki, Takeshi Kawamoto, Keiji Tanimoto, Masahiko Nishiyama, Hiroaki Honda & Yukio Kato. (2002) Identification of Functional Hypoxia Response Elements in the Promoter Region of the DEC1 and DEC2 Genes. Journal of Biological Chemistry 277:49, pages 47014-47021.
Crossref
Thomas Hofer, Isabelle Desbaillets, Gisele Höpfl, Roland H Wenger & Max Gassmann. (2002) Characterization of HIF-1α overexpressing HeLa cells and implications for gene therapy. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 133:4, pages 475-481.
Crossref
Koh Nakayama, Kyung-Woon Kim & Atsushi Miyajima. (2002) A novel nuclear zinc finger protein EZI enhances nuclear retention and transactivation of STAT3. The EMBO Journal 21:22, pages 6174-6184.
Crossref
Tilman Sánchez-Elsner, Luisa M. Botella, Beatriz Velasco, Carmen Langa & Carmelo Bernabéu. (2002) Endoglin Expression Is Regulated by Transcriptional Cooperation between the Hypoxia and Transforming Growth Factor-β Pathways. Journal of Biological Chemistry 277:46, pages 43799-43808.
Crossref
K Ameri, B Burke, C E Lewis & A L Harris. (2002) Regulation of a rat VL30 element in human breast cancer cells in hypoxia and anoxia: role of HIF-1. British Journal of Cancer 87:10, pages 1173-1181.
Crossref
Jorge L. Ruas, Lorenz Poellinger & Teresa Pereira. (2002) Functional Analysis of Hypoxia-inducible Factor-1α-mediated Transactivation. Journal of Biological Chemistry 277:41, pages 38723-38730.
Crossref
Roland H. Wenger. (2002) Cellular adaptation to hypoxia: O 2 ‐sensing protein hydroxylases, hypoxia‐inducible transcription factors, and O 2 ‐regulated gene expression . The FASEB Journal 16:10, pages 1151-1162.
Crossref
Scott Earley & Thomas C. Resta. (2002) Estradiol attenuates hypoxia-induced pulmonary endothelin-1 gene expression. American Journal of Physiology-Lung Cellular and Molecular Physiology 283:1, pages L86-L93.
Crossref
Yan-Shan Dai, Peter Cserjesi, Bruce E. Markham & Jeffery D. Molkentin. (2002) The Transcription Factors GATA4 and dHAND Physically Interact to Synergistically Activate Cardiac Gene Expression through a p300-dependent Mechanism. Journal of Biological Chemistry 277:27, pages 24390-24398.
Crossref
Daniel J. Bertges, Sören Berg, Mitchell P. Fink & Russell L. Delude. (2002) Regulation of Hypoxia-Inducible Factor 1 in Enterocytic Cells. Journal of Surgical Research 106:1, pages 157-165.
Crossref
Steven J. Freedman, Zhen-Yu J. Sun, Florence Poy, Andrew L. Kung, David M. Livingston, Gerhard Wagner & Michael J. Eck. (2002) Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1α. Proceedings of the National Academy of Sciences 99:8, pages 5367-5372.
Crossref
B.G Wouters, S.A Weppler, M Koritzinsky, W Landuyt, S Nuyts, J Theys, R.K Chiu & P Lambin. (2002) Hypoxia as a target for combined modality treatments. European Journal of Cancer 38:2, pages 240-257.
Crossref
Masaya Nagao, Seiji Masuda, Mariko Chikuma-Esaki, Toshihiro Kobayashi & Ryuzo Sasaki. 2002. Animal Cell Technology: Basic & Applied Aspects. Animal Cell Technology: Basic & Applied Aspects 325 329 .
Ingo Flamme & Georg Breier. 2002. Assembly of the Vasculature and Its Regulation. Assembly of the Vasculature and Its Regulation 21 54 .
Thomas Hofer, Isabelle Desbaillets, Gisele Höpfl, Max Gassmann & Roland H. Wenger. (2001) Dissecting hypoxia‐dependent and hypoxia‐independent steps in the HIF‐1α activation cascade: implications for HIF‐1α gene therapy. The FASEB Journal 15:14, pages 1-23.
Crossref
Joy L. Huffman, Asawari Mokashi, Hans Peter Bächinger & Richard G. Brennan. (2001) The Basic Helix-Loop-Helix Domain of the Aryl Hydrocarbon Receptor Nuclear Transporter (ARNT) Can Oligomerize and Bind E-box DNA Specifically. Journal of Biological Chemistry 276:44, pages 40537-40544.
Crossref
Itamar Goren, Einat Tavor, Amiram Goldblum & Alik Honigman. (2001) Two cysteine residues in the DNA-binding domain of CREB control binding to CRE and CREB-mediated gene expression. Journal of Molecular Biology 313:4, pages 695-709.
Crossref
Angeline S. Andrew, Linda R. Klei & Aaron Barchowsky. (2001) AP-1-dependent induction of plasminogen activator inhibitor-1 by nickel does not require reactive oxygen. American Journal of Physiology-Lung Cellular and Molecular Physiology 281:3, pages L616-L623.
Crossref
Angeline S. Andrew, Linda R. Klei & Aaron Barchowsky. (2001) Nickel requires hypoxia-inducible factor-1α, not redox signaling, to induce plasminogen activator inhibitor-1. American Journal of Physiology-Lung Cellular and Molecular Physiology 281:3, pages L607-L615.
Crossref
Gregg L. Semenza. (2001) Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology. Trends in Molecular Medicine 7:8, pages 345-350.
Crossref
Takashi Kitaura, Naoko Tsunekawa & Hideo Hatta. (2001) Decreased monocarboxylate transporter 1 in rat soleus and EDL muscles exposed to clenbuterol. Journal of Applied Physiology 91:1, pages 85-90.
Crossref
Bernard B. Rees, John A. L. Bowman & Patricia M. Schulte. (2001) Structure and Sequence Conservation of a Putative Hypoxia Response Element in the Lactate Dehydrogenase-B Gene of Fundulus . The Biological Bulletin 200:3, pages 247-251.
Crossref
Jaime Caro. (2001) Hypoxia Regulation of Gene Transcription. High Altitude Medicine & Biology 2:2, pages 145-154.
Crossref
Minghua Nie, Alan L. Blankenship & John P. Giesy. (2001) Interactions between aryl hydrocarbon receptor (AhR) and hypoxia signaling pathways. Environmental Toxicology and Pharmacology 10:1-2, pages 17-27.
Crossref
Eunseon Hur, Keun Young Chang, Eunjung Lee, Seung-Ki Lee & Hyunsung Park. (2001) Mitogen-Activated Protein Kinase Kinase Inhibitor PD98059 Blocks the trans -Activation but Not the Stabilization or DNA Binding Ability of Hypoxia-Inducible Factor-1α . Molecular Pharmacology 59:5, pages 1216-1224.
Crossref
Kazuhito Yamashita, Daryl J. Discher, Jing Hu, Nanette H. Bishopric & Keith A. Webster. (2001) Molecular Regulation of the Endothelin-1 Gene by Hypoxia. Journal of Biological Chemistry 276:16, pages 12645-12653.
Crossref
Tatiana I. Slepak, Keith A. Webster, Jie Zang, Howard Prentice, Ann O'Dowd, Martin N. Hicks & Nanette H. Bishopric. (2001) Control of Cardiac-specific Transcription by p300 through Myocyte Enhancer Factor-2D. Journal of Biological Chemistry 276:10, pages 7575-7585.
Crossref
Matthew J. Grimshaw & Frances R. Balkwill. (2001) Inhibition of monocyte and macrophage chemotaxis by hypoxia and inflammation - a potential mechanism. European Journal of Immunology 31:2, pages 480-489.
Crossref
Mariko Chikuma, Seiji Masuda, Toshihiro Kobayashi, Masaya Nagao & Ryuzo Sasaki. (2000) Tissue-specific regulation of erythropoietin production in the murine kidney, brain, and uterus. American Journal of Physiology-Endocrinology and Metabolism 279:6, pages E1242-E1248.
Crossref
Andrew L. Kung, Stream Wang, Jeffery M. Klco, William G. Kaelin & David M. Livingston. (2000) Suppression of tumor growth through disruption of hypoxia-inducible transcription. Nature Medicine 6:12, pages 1335-1340.
Crossref
Taiho KambeJunko Tada-KambeYoshihiro KugeYuko Yamaguchi-IwaiMasaya NagaoRyuzo Sasaki. (2000) Retinoic acid stimulates erythropoietin gene transcription in embryonal carcinoma cells through the direct repeat of a steroid/thyroid hormone receptor response element half-site in the hypoxia-response enhancer. Blood 96:9, pages 3265-3271.
Crossref
Taiho KambeJunko Tada-KambeYoshihiro KugeYuko Yamaguchi-IwaiMasaya NagaoRyuzo Sasaki. (2000) Retinoic acid stimulates erythropoietin gene transcription in embryonal carcinoma cells through the direct repeat of a steroid/thyroid hormone receptor response element half-site in the hypoxia-response enhancer. Blood 96:9, pages 3265-3271.
Crossref
Karen A. VincentKou-Gi ShyuYuxia LuoMeredith MagnerRene A. TioCanwen JiangMark A. GoldbergGeoffrey Y. AkitaRichard J. GregoryJeffrey M. Isner. (2000) Angiogenesis Is Induced in a Rabbit Model of Hindlimb Ischemia by Naked DNA Encoding an HIF-1α/VP16 Hybrid Transcription Factor. Circulation 102:18, pages 2255-2261.
Crossref
G.U Dachs & G.M Tozer. (2000) Hypoxia modulated gene expression: angiogenesis, metastasis and therapeutic exploitation. European Journal of Cancer 36:13, pages 1649-1660.
Crossref
Madhu GuptaPaul T. MungaiEugene Goldwasser. (2000) A new transacting factor that modulates hypoxia-induced expression of the erythropoietin gene. Blood 96:2, pages 491-497.
Crossref
Madhu GuptaPaul T. MungaiEugene Goldwasser. (2000) A new transacting factor that modulates hypoxia-induced expression of the erythropoietin gene. Blood 96:2, pages 491-497.
Crossref

Displaying 200 of 214 citing articles. Use the download link below to view the full list of citing articles.

Download full citations list

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.