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Molecular and Cellular Biology Volume 18, 1998 - Issue 7
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Cell Growth and Development

Tyrosine 1101 of Tie2 Is the Major Site of Association of p85 and Is Required for Activation of Phosphatidylinositol 3-Kinase and Akt

Christopher D. Kontosa Departments of Medicine
,
Thomas P. Staufferb Cell Biology
,
Wen-Pin Yangd Department of Cardiovascular Drug Discovery, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey08543
,
John D. Yorkc Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina27710
,
Liwen Huanga Departments of Medicine
,
Michael A. Blanard Department of Cardiovascular Drug Discovery, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey08543
,
Tobias Meyerb Cell Biology;c Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina27710
&
Kevin G. Petersa Departments of Medicine;c Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina27710Correspondence[email protected]
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Pages 4131-4140 | Received 04 Dec 1997, Accepted 28 Apr 1998, Published online: 28 Mar 2023

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Jay Bilimoria & Harprit Singh. (2019) The Angiopoietin ligands and Tie receptors: potential diagnostic biomarkers of vascular disease. Journal of Receptors and Signal Transduction 39:3, pages 187-193.
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Hai Tao Yuan, Eliyahu V. Khankin, S. Ananth Karumanchi & Samir M. Parikh. (2009) Angiopoietin 2 Is a Partial Agonist/Antagonist of Tie2 Signaling in the Endothelium. Molecular and Cellular Biology 29:8, pages 2011-2022.
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Haruna Takano, Satoshi Murasawa & Takayuki Asahara. (2008) Functional and gene expression analysis of hTERT overexpressed endothelial cells. Biologics: Targets and Therapy 2:3, pages 547-554.
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Kazunobu Tachibana, Nina Jones, Daniel J. Dumont, Mira C. Puri & Alan Bernstein. (2005) Selective Role of a Distinct Tyrosine Residue on Tie2 in Heart Development and Early Hematopoiesis. Molecular and Cellular Biology 25:11, pages 4693-4702.
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Stelios Tsigkos, Micheal Koutsilieris & Andreas Papapetropoulos. (2003) Angiopoietins in angiogenesis and beyond. Expert Opinion on Investigational Drugs 12:6, pages 933-941.
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Nina Jones, Stephen H. Chen, Celina Sturk, Zubin Master, Jennifer Tran, Robert S. Kerbel & Daniel J. Dumont. (2003) A Unique Autophosphorylation Site on Tie2/Tek Mediates Dok-R Phosphotyrosine Binding Domain Binding and Function. Molecular and Cellular Biology 23:8, pages 2658-2668.
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Christopher D. Kontos, Eugene H. Cha, John D. York & Kevin G. Peters. (2002) The Endothelial Receptor Tyrosine Kinase Tie1 Activates Phosphatidylinositol 3-Kinase and Akt To Inhibit Apoptosis. Molecular and Cellular Biology 22:6, pages 1704-1713.
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Iiro Rajantie, Niklas Ekman, Kristiina Iljin, Elena Arighi, Yuji Gunji, Jaakko Kaukonen, Aarno Palotie, Mieke Dewerchin, Peter Carmeliet & Kari Alitalo. (2001) Bmx Tyrosine Kinase Has a Redundant Function Downstream of Angiopoietin and Vascular Endothelial Growth Factor Receptors in Arterial Endothelium. Molecular and Cellular Biology 21:14, pages 4647-4655.
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