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Molecular and Cellular Biology Volume 18, 1998 - Issue 7
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Transcriptional Regulation

The Syk Protein Tyrosine Kinase Is Essential for Fcγ Receptor Signaling in Macrophages and Neutrophils

Friedemann Kiefera Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, OntarioM5G 1X5
,
John Brumella Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, OntarioM5G 1X5;b Hospital for Sick Children, Toronto, OntarioM5G 1X8
,
Nadia Al-Alawia Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, OntarioM5G 1X5
,
Sylvain Latourc McGill Cancer Centre, McGill University, Montreal, QuebecH3G 1Y6
,
Alec Chenga Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, OntarioM5G 1X5
,
André Veillettec McGill Cancer Centre, McGill University, Montreal, QuebecH3G 1Y6
,
Sergio Grinsteinb Hospital for Sick Children, Toronto, OntarioM5G 1X8
&
Tony Pawsona Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, OntarioM5G 1X5;d Department of Molecular and Medical Genetics, University of Toronto, Toronto, OntarioM5S 1A8, CanadaCorrespondence[email protected]
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Pages 4209-4220 | Received 24 Feb 1998, Accepted 20 Apr 1998, Published online: 28 Mar 2023

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Nichola Cooper, Waleed Ghanima, Quentin A Hill, Phillip LR Nicolson, Vadim Markovtsov & Craig Kessler. (2023) Recent advances in understanding spleen tyrosine kinase (SYK) in human biology and disease, with a focus on fostamatinib. Platelets 34:1.
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Vijay Kumar. (2020) Phagocytosis: Phenotypically Simple Yet a Mechanistically Complex Process. International Reviews of Immunology 39:3, pages 118-150.
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Vanessa Weis, Sebastian Königsberger, Susanne Amler, Jürgen Wienands & Friedemann Kiefer. (2017) Unperturbed Immune Function despite Mutation of C-Terminal Tyrosines in Syk Previously Implicated in Signaling and Activity Regulation. Molecular and Cellular Biology 37:21.
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Mariska Meijer, Ger T Rijkers & Frans J van Overveld. (2013) Neutrophils and emerging targets for treatment in chronic obstructive pulmonary disease. Expert Review of Clinical Immunology 9:11, pages 1055-1068.
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Debjani Ghosh & George C. Tsokos. (2010) Spleen tyrosine kinase: An Src family of non-receptor kinase has multiple functions and represents a valuable therapeutic target in the treatment of autoimmune and inflammatory diseases. Autoimmunity 43:1, pages 48-55.
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Farhad Abtahian, Natalie Bezman, Regina Clemens, Eric Sebzda, Lan Cheng, Sanford J. Shattil, Mark L. Kahn & Gary A. Koretzky. (2006) Evidence for the Requirement of ITAM Domains but Not SLP-76/Gads Interaction for Integrin Signaling in Hematopoietic Cells. Molecular and Cellular Biology 26:18, pages 6936-6949.
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Marina Ulanova, Florentina Duta, Lakshmi Puttagunta, Alan D Schreiber & A Dean Befus. (2005) Spleen tyrosine kinase (Syk) as a novel target for allergic asthma and rhinitis. Expert Opinion on Therapeutic Targets 9:5, pages 901-921.
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Akira Nakamura, Kenichi Akiyama & Toshiyuki Takai. (2005) Fc receptor targeting in the treatment of allergy, autoimmune diseases and cancer. Expert Opinion on Therapeutic Targets 9:1, pages 169-190.
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Regina A. Clemens, Sally A. Newbrough, Elaine Y. Chung, Shereen Gheith, Andrew L. Singer, Gary A. Koretzky & Erik J. Peterson. (2004) PRAM-1 Is Required for Optimal Integrin-Dependent Neutrophil Function. Molecular and Cellular Biology 24:24, pages 10923-10932.
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Brian R Wong, Elliott B Grossbard, Donald G Payan & Esteban S Masuda. (2004) Targeting Syk as a treatment for allergic and autoimmune disorders. Expert Opinion on Investigational Drugs 13:7, pages 743-762.
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Jean-Max Pasquet, Barbara Gross, Lynn Quek, Naoki Asazuma, Weiguo Zhang, Connie L. Sommers, Edina Schweighoffer, Victor Tybulewicz, Barbara Judd, Jong Ran Lee, Gary Koretzky, Paul E. Love, Lawrence E. Samelson & Steve P. Watson. (1999) LAT Is Required for Tyrosine Phosphorylation of Phospholipase Cγ2 and Platelet Activation by the Collagen Receptor GPVI. Molecular and Cellular Biology 19:12, pages 8326-8334.
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Jeroen E. M. van Leeuwen, Paul K. Paik & Lawrence E. Samelson. (1999) The Oncogenic 70Z Cbl Mutation Blocks the Phosphotyrosine Binding Domain-Dependent Negative Regulation of ZAP-70 by c-Cbl in Jurkat T Cells. Molecular and Cellular Biology 19:10, pages 6652-6664.
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