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Transcriptional Regulation

Interplay of Positive and Negative Regulators in Transcription Initiation by RNA Polymerase II Holoenzyme

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Pages 4455-4462 | Received 01 Apr 1998, Accepted 21 May 1998, Published online: 27 Mar 2023

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Jason E. Miller & Joseph C. Reese. (2012) Ccr4-Not complex: the control freak of eukaryotic cells. Critical Reviews in Biochemistry and Molecular Biology 47:4, pages 315-333.
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Eve Lenssen, Nicole James, Ivo Pedruzzi, Frédérique Dubouloz, Elisabetta Cameroni, Ruth Bisig, Laurent Maillet, Michel Werner, Johnny Roosen, Katarina Petrovic, Joris Winderickx, Martine A. Collart & Claudio De Virgilio. (2005) The Ccr4-Not Complex Independently Controls both Msn2-Dependent Transcriptional Activation—via a Newly Identified Glc7/Bud14 Type I Protein Phosphatase Module—and TFIID Promoter Distribution. Molecular and Cellular Biology 25:1, pages 488-498.
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Marcin P. Klejman, Lloyd A. Pereira, Hester J. T. van Zeeburg, Siv Gilfillan, Michael Meisterernst & H. T. Marc Timmers. (2004) NC2α Interacts with BTAF1 and Stimulates Its ATP-Dependent Association with TATA-Binding Protein. Molecular and Cellular Biology 24:22, pages 10072-10082.
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Cyril Berthet, Anne-Marie Morera, Marie-Jeanne Asensio, Marie-Agnes Chauvin, Anne-Pierre Morel, Frederique Dijoud, Jean-Pierre Magaud, Philippe Durand & Jean-Pierre Rouault. (2004) CCR4-Associated Factor CAF1 Is an Essential Factor for Spermatogenesis. Molecular and Cellular Biology 24:13, pages 5808-5820.
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Hongfang Qiu, Cuihua Hu, Sungpil Yoon, Krishnamurthy Natarajan, Mark J. Swanson & Alan G. Hinnebusch. (2004) An Array of Coactivators Is Required for Optimal Recruitment of TATA Binding Protein and RNA Polymerase II by Promoter-Bound Gcn4p. Molecular and Cellular Biology 24:10, pages 4104-4117.
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Mark J. Swanson, Hongfang Qiu, Laarni Sumibcay, Anna Krueger, Soon-ja Kim, Krishnamurthy Natarajan, Sungpil Yoon & Alan G. Hinnebusch. (2003) A Multiplicity of Coactivators Is Required by Gcn4p at Individual Promoters In Vivo. Molecular and Cellular Biology 23:8, pages 2800-2820.
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Joseph V. Geisberg, Zarmik Moqtaderi, Laurent Kuras & Kevin Struhl. (2002) Mot1 Associates with Transcriptionally Active Promoters and Inhibits Association of NC2 in Saccharomyces cerevisiae. Molecular and Cellular Biology 22:23, pages 8122-8134.
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Cécile Deluen, Nicole James, Laurent Maillet, Miguel Molinete, Grégory Theiler, Marc Lemaire, Nicole Paquet & Martine A. Collart. (2002) The Ccr4-Not Complex and yTAF1 (yTafII130p/yTafII145p) Show Physical and Functional Interactions. Molecular and Cellular Biology 22:19, pages 6735-6749.
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Joseph V. Geisberg, Frank C. Holstege, Richard A. Young & Kevin Struhl. (2001) Yeast NC2 Associates with the RNA Polymerase II Preinitiation Complex and Selectively Affects Transcription In Vivo. Molecular and Cellular Biology 21:8, pages 2736-2742.
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Sungjoon Kim, Kettly Cabane, Michael Hampsey & Danny Reinberg. (2000) Genetic Analysis of the Ydr1-Bur6 Repressor Complex Reveals an Intricate Balance among Transcriptional Regulatory Proteins in Yeast. Molecular and Cellular Biology 20:7, pages 2455-2465.
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Joseph V. Geisberg & Kevin Struhl. (2000) TATA-Binding Protein Mutants That Increase Transcription from Enhancerless and Repressed Promoters In Vivo. Molecular and Cellular Biology 20:5, pages 1478-1488.
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Tsukasa Oda, Kentaro Kayukawa, Hiroko Hagiwara, Henrik T. Yudate, Yasuhiko Masuho, Yasufumi Murakami, Taka-aki Tamura & Masa-aki Muramatsu. (2000) A Novel TATA-Binding Protein-Binding Protein, ABT1, Activates Basal Transcription and Has a Yeast Homolog That Is Essential for Growth. Molecular and Cellular Biology 20:4, pages 1407-1418.
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Yongli Bai, Christopher Salvadore, Yueh-Chin Chiang, Martine A. Collart, Hai-Yan Liu & Clyde L. Denis. (1999) The CCR4 and CAF1 Proteins of the CCR4-NOT Complex Are Physically and Functionally Separated from NOT2, NOT4, and NOT5. Molecular and Cellular Biology 19:10, pages 6642-6651.
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Young Chul Lee, Jin Mo Park, Soyoung Min, Sang Jun Han & Young-Joon Kim. (1999) An Activator Binding Module of Yeast RNA Polymerase II Holoenzyme. Molecular and Cellular Biology 19:4, pages 2967-2976.
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Sang Jun Han, Young Chul Lee, Byung Soo Gim, Gi-Hyuck Ryu, Soon Jung Park, William S. Lane & Young-Joon Kim. (1999) Activator-Specific Requirement of Yeast Mediator Proteins for RNA Polymerase II Transcriptional Activation. Molecular and Cellular Biology 19:2, pages 979-988.
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Crossref
Lorena Peiró-Chova & Francisco Estruch. (2009) The Yeast RNA Polymerase II-associated Factor Iwr1p Is Involved in the Basal and Regulated Transcription of Specific Genes. Journal of Biological Chemistry 284:42, pages 28958-28967.
Crossref
André Boorsma, Xiang-Jun Lu, Anna Zakrzewska, Frans M. Klis & Harmen J. Bussemaker. (2008) Inferring Condition-Specific Modulation of Transcription Factor Activity in Yeast through Regulon-Based Analysis of Genomewide Expression. PLoS ONE 3:9, pages e3112.
Crossref
Folkert J. van Werven, Harm van Bakel, Hetty A.A.M. van Teeffelen, A.F. Maarten Altelaar, Marian Groot Koerkamp, Albert J.R. Heck, Frank C.P. Holstege & H.Th. Marc Timmers. (2008) Cooperative action of NC2 and Mot1p to regulate TATA-binding protein function across the genome. Genes & Development 22:17, pages 2359-2369.
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Crossref
Klaas W Mulder, Akiko Inagaki, Elisabetta Cameroni, Florence Mousson, G Sebastiaan Winkler, Claudio De Virgilio, Martine A Collart & H Th Marc Timmers. (2007) Modulation of Ubc4p/Ubc5p-Mediated Stress Responses by the RING-Finger-Dependent Ubiquitin-Protein Ligase Not4p in Saccharomyces cerevisiae . Genetics 176:1, pages 181-192.
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Crossref
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Crossref
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Crossref
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Crossref
G.Sebastiaan Winkler, Thomas K. Albert, Cyril Dominguez, Yvonne I.A. Legtenberg, Rolf Boelens & H.Th.Marc Timmers. (2004) An Altered-specificity Ubiquitin-conjugating Enzyme/Ubiquitin–Protein Ligase Pair. Journal of Molecular Biology 337:1, pages 157-165.
Crossref
Martine A. Collart & H.Th.Marc Timmers. 2004. Progress in Nucleic Acid Research and Molecular Biology Volume 77. Progress in Nucleic Acid Research and Molecular Biology Volume 77 289 322 .
Stefan Björklund & Claes M Gustafsson. 2004. Proteins in Eukaryotic Transcription. Proteins in Eukaryotic Transcription 43 65 .
Lloyd A. Pereira, Marcin P. Klejman & H.Th.Marc Timmers. (2003) Roles for BTAF1 and Mot1p in dynamics of TATA-binding protein and regulation of RNA polymerase II transcription. Gene 315, pages 1-13.
Crossref
Brian A. Lewis & Danny Reinberg. (2003) The mediator coactivator complex: functional and physical roles in transcriptional regulation. Journal of Cell Science 116:18, pages 3667-3675.
Crossref
James Flanagan, Sue Healey, Joanne Young, Vicki Whitehall & Georgia Chenevix‐Trench. (2003) Analysis of the transcription regulator, CNOT7 , as a candidate chromosome 8 tumor suppressor gene in colorectal cancer . International Journal of Cancer 106:4, pages 505-509.
Crossref
Martine A Collart. (2003) Global control of gene expression in yeast by the Ccr4-Not complex. Gene 313, pages 1-16.
Crossref
Clyde L Denis & Junji Chen. 2003. 221 250 .
Sandrine Creton, Jesper Q. Svejstrup & Martine A. Collart. (2002) The NC2 α and β subunits play different roles in vivo. Genes & Development 16:24, pages 3265-3276.
Crossref
Yong Cang & Gregory Prelich. (2002) Direct stimulation of transcription by negative cofactor 2 (NC2) through TATA-binding protein (TBP). Proceedings of the National Academy of Sciences 99:20, pages 12727-12732.
Crossref
Pamela Russell, John D. Benson & Clyde L. Denis. (2002) Characterization of Mutations in NOT2 Indicates that it Plays an Important Role in Maintaining the Integrity of the CCR4–NOT Complex. Journal of Molecular Biology 322:1, pages 27-39.
Crossref
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Crossref
Susie C. Howard, Yelena V. Budovskaya, Ya-Wen Chang & Paul K. Herman. (2002) The C-terminal Domain of the Largest Subunit of RNA Polymerase II Is Required for Stationary Phase Entry and Functionally Interacts with the Ras/PKA Signaling Pathway. Journal of Biological Chemistry 277:22, pages 19488-19497.
Crossref
Thomas K. Albert, Hiroyuki Hanzawa, Yvonne I.A. Legtenberg, Marjolein J. de Ruwe, Fiona A.J. van den Heuvel, Martine A. Collart, Rolf Boelens & H.Th.Marc Timmers. (2002) Identification of a ubiquitin-protein ligase subunit within the CCR4-NOT transcription repressor complex. The EMBO Journal 21:3, pages 355-364.
Crossref
E. Lenssen, U. Oberholzer, J. Labarre, C. De Virgilio & M. A. Collart. (2002) Saccharomyces cerevisiae Ccr4-Not complex contributes to the control of Msn2p-dependent transcription by the Ras/cAMP pathway. Molecular Microbiology 43:4, pages 1023-1037.
Crossref
Laurent Maillet & Martine A. Collart. (2002) Interaction between Not1p, a Component of the Ccr4-Not Complex, a Global Regulator of Transcription, and Dhh1p, a Putative RNA Helicase. Journal of Biological Chemistry 277:4, pages 2835-2842.
Crossref
Junji Chen, Juri Rappsilber, Yueh-Chin Chiang, Pamela Russell, Matthias Mann & Clyde L Denis. (2001) Purification and characterization of the 1.0 MDa CCR4-NOT complex identifies two novel components of the complex 1 1Edited by D. Draper. Journal of Molecular Biology 314:4, pages 683-694.
Crossref
Jong Seok Kang, Seung Hyun Kim, Moon Sun Hwang, Sang Jun Han, Young Chul Lee & Young-Joon Kim. (2001) The Structural and Functional Organization of the Yeast Mediator Complex. Journal of Biological Chemistry 276:45, pages 42003-42010.
Crossref
Sang Jun Han, Jung-Soon Lee, Jong Seok Kang & Young-Joon Kim. (2001) Med9/Cse2 and Gal11 Modules Are Required for Transcriptional Repression of Distinct Group of Genes. Journal of Biological Chemistry 276:40, pages 37020-37026.
Crossref
Katsuhiko Kamada, Fong Shu, Hua Chen, Sohail Malik, Gertraud Stelzer, Robert G. Roeder, Michael Meisterernst & Stephen K. Burley. (2001) Crystal Structure of Negative Cofactor 2 Recognizing the TBP-DNA Transcription Complex. Cell 106:1, pages 71-81.
Crossref
Clyde L Denis, Yueh-Chin Chiang, Yajun Cui & Junji Chen. (2001) Genetic Evidence Supports a Role for the Yeast CCR4-NOT Complex in Transcriptional Elongation. Genetics 158:2, pages 627-634.
Crossref
Hiroyuki Hanzawa, Marjolein J. de Ruwe, Thomas K. Albert, Peter C. van der Vliet, H. T. Marc Timmers & Rolf Boelens. (2001) The Structure of the C4C4RING Finger of Human NOT4 Reveals Features Distinct from Those of C3HC4 RING Fingers. Journal of Biological Chemistry 276:13, pages 10185-10190.
Crossref
Hai-Yan Liu, Yueh-Chin Chiang, Jing Pan, Junji Chen, Christopher Salvadore, Deborah C. Audino, Vasudeo Badarinarayana, Viswanathan Palaniswamy, Bradley Anderson & Clyde L. Denis. (2001) Characterization of CAF4 and CAF16 Reveals a Functional Connection between the CCR4-NOT Complex and a Subset of SRB Proteins of the RNA Polymerase II Holoenzyme. Journal of Biological Chemistry 276:10, pages 7541-7548.
Crossref
Maksum Radji, Jong-Myong Kim, Takahiro Togan, Hiroshi Yoshikawa & Katsuhiko Shirahige. (2001) The cloning and characterization of theCDC50 gene family inSaccharomyces cerevisiae. Yeast 18:3, pages 195-205.
Crossref
J. R. Bone & S. Y. Roth. 2001. Transcriptional Corepressors: Mediators of Eukaryotic Gene Repression. Transcriptional Corepressors: Mediators of Eukaryotic Gene Repression 59 78 .
Muriel Boube, Christian Faucher, Laurent Joulia, David L. Cribbs & Henri-Marc Bourbon. (2000) Drosophila homologs of transcriptional mediator complex subunits are required for adult cell and segment identity specification . Genes & Development 14:22, pages 2906-2917.
Crossref
Laurent Maillet, Chi Tu, Young Kwon Hong, Elisabeth O Shuster & Martine A Collart. (2000) The essential function of not1 lies within the Ccr4-not complex. Journal of Molecular Biology 303:2, pages 131-143.
Crossref
B.Franklin Pugh. (2000) Control of gene expression through regulation of the TATA-binding protein. Gene 255:1, pages 1-14.
Crossref
Marc Lemaire & Martine A. Collart. (2000) The TATA-binding Protein-associated Factor yTafII19p Functionally Interacts with Components of the Global Transcriptional Regulator Ccr4-Not Complex and Physically Interacts with the Not5 Subunit. Journal of Biological Chemistry 275:35, pages 26925-26934.
Crossref
Vasudeo Badarinarayana, Yueh-Chin Chiang & Clyde L Denis. (2000) Functional Interaction of CCR4-NOT Proteins With TATAA-Binding Protein (TBP) and Its Associated Factors in Yeast. Genetics 155:3, pages 1045-1054.
Crossref
Lawrence C. Myers & Roger D. Kornberg. (2000) Mediator of Transcriptional Regulation. Annual Review of Biochemistry 69:1, pages 729-749.
Crossref
Marc Lemaire, Jun Xie, Michael Meisterernst & Martine A. Collart. (2000) The NC2 repressor is dispensable in yeast mutated for the Sin4p component of the holoenzyme and plays roles similar to Mot1p in vivo. Molecular Microbiology 36:1, pages 163-173.
Crossref
Jun Xie, Martine Collart, Marc Lemaire, Gertraud Stelzer & Michael Meisterernst. (2000) A single point mutation in TFIIA suppresses NC2 requirement in vivo. The EMBO Journal 19:4, pages 672-682.
Crossref
Edio Maldonado, Michael Hampsey & Danny Reinberg. (1999) Repression. Cell 99:5, pages 455-458.
Crossref
Hua Xiao, Yong Tao & Robert G. Roeder. (1999) The Human Homologue of Drosophila TRF-proximal Protein Is Associated with an RNA Polymerase II-SRB Complex. Journal of Biological Chemistry 274:7, pages 3937-3940.
Crossref
Jeffrey A. Ranish, Natalya Yudkovsky & Steven Hahn. (1999) Intermediates in formation and activity of the RNA polymerase II preinitiation complex: holoenzyme recruitment and a postrecruitment role for the TATA box and TFIIB. Genes & Development 13:1, pages 49-63.
Crossref
Frank C.P Holstege, Ezra G Jennings, John J Wyrick, Tong Ihn Lee, Christoph J Hengartner, Michael R Green, Todd R Golub, Eric S Lander & Richard A Young. (1998) Dissecting the Regulatory Circuitry of a Eukaryotic Genome. Cell 95:5, pages 717-728.
Crossref
Vic E. Myer & Richard A. Young. (1998) RNA Polymerase II Holoenzymes and Subcomplexes. Journal of Biological Chemistry 273:43, pages 27757-27760.
Crossref

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