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Cell Growth and Development

Loss of IκBα-Mediated Control over Nuclear Import and DNA Binding Enables Oncogenic Activation of c-Rel

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Pages 5445-5456 | Received 13 Mar 1998, Accepted 10 Jun 1998, Published online: 28 Mar 2023

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Åsa Antonsson, Kate Hughes, Sofia Edin & Thomas Grundstrüm. (2003) Regulation of c-Rel Nuclear Localization by Binding of Ca2+/Calmodulin. Molecular and Cellular Biology 23:4, pages 1418-1427.
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Tony T. Huang & Shigeki Miyamoto. (2001) Postrepression Activation of NF-κB Requires the Amino-Terminal Nuclear Export Signal Specific to IκBα. Molecular and Cellular Biology 21:14, pages 4737-4747.
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Winnie F. Tam, Linda H. Lee, Laura Davis & Ranjan Sen. (2000) Cytoplasmic Sequestration of Rel Proteins by IκBα Requires CRM1-Dependent Nuclear Export. Molecular and Cellular Biology 20:6, pages 2269-2284.
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Shrikesh Sachdev, Sriparna Bagchi, Donna D. Zhang, Angela C. Mings & Mark Hannink. (2000) Nuclear Import of IκBα Is Accomplished by a Ran-Independent Transport Pathway. Molecular and Cellular Biology 20:5, pages 1571-1582.
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Robert Weil, Hüseyin Sirma, Carlo Giannini, Dina Kremsdorf, Christine Bessia, Catherine Dargemont, Christian Bréchot & Alain Israël. (1999) Direct Association and Nuclear Import of the Hepatitis B Virus X Protein with the NF-κB Inhibitor IκBα. Molecular and Cellular Biology 19:9, pages 6345-6354.
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Articles from other publishers (37)

Chia-Mei Liu, Wen-Hsin Hsu, Wan-Yi Lin & Hong-Chen Chen. (2017) Adducin family proteins possess different nuclear export potentials. Journal of Biomedical Science 24:1.
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Lindsay Lundberg, Chelsea Pinkham, Cynthia de la Fuente, Ashwini Brahms, Nazly Shafagati, Kylie M. Wagstaff, David A. Jans, Sharon Tamir & Kylene Kehn-Hall. (2016) Selective Inhibitor of Nuclear Export (SINE) Compounds Alter New World Alphavirus Capsid Localization and Reduce Viral Replication in Mammalian Cells. PLOS Neglected Tropical Diseases 10:11, pages e0005122.
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Louis K Ho & Justin R Nodwell. (2016) David and Goliath: chemical perturbation of eukaryotes by bacteria. Journal of Industrial Microbiology and Biotechnology 43:2-3, pages 233-248.
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Dominik Niopek, Pierre Wehler, Julia Roensch, Roland Eils & Barbara Di Ventura. (2016) Optogenetic control of nuclear protein export. Nature Communications 7:1.
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Li-Zhu Jiang, Peng Wang, Bi Deng, Chuang Huang, Wei-Xue Tang, Hong-Yi Lu & Hong-Yan Chen. (2011) Overexpression of Forkhead Box M1 transcription factor and nuclear factor–κB in laryngeal squamous cell carcinoma: a potential indicator for poor prognosis. Human Pathology 42:8, pages 1185-1193.
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Richa Tiwari, William Bargmann & Henry R. BoseJr.Jr.. (2011) Activation of the TGF-β/Smad signaling pathway in oncogenic transformation by v-Rel. Virology 413:1, pages 60-71.
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Gaofeng Fan, Yongjun Fan, Nupur Gupta, Isao Matsuura, Fang Liu, Xiao Zhen Zhou, Kun Ping Lu & Céline Gélinas. (2009) Peptidyl-Prolyl Isomerase Pin1 Markedly Enhances the Oncogenic Activity of the Rel Proteins in the Nuclear Factor-κB Family. Cancer Research 69:11, pages 4589-4597.
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S Tong, A S Liss, M You & H R BoseJrJr. (2006) The activation of TC10, a Rho small GTPase, contributes to v-Rel-mediated transformation. Oncogene 26:16, pages 2318-2329.
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S M Majid, A S Liss, M You & H R BoseJrJr. (2005) The suppression of SH3BGRL is important for v-Rel-mediated transformation. Oncogene 25:5, pages 756-768.
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Yongjun Fan, Jui Dutta, Nupur Gupta & Céline Gélinas. 2006. NF-κB/Rel Transcription Factor Family. NF-κB/Rel Transcription Factor Family 112 130 .
Daniel T Starczynowski, Joseph G Reynolds & Thomas D Gilmore. (2005) Mutations of tumor necrosis factor α-responsive serine residues within the C-terminal transactivation domain of human transcription factor REL enhance its in vitro transforming ability. Oncogene 24:49, pages 7355-7368.
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Y.Y. Yu, Q. Li & Z.G. Zhu. (2005) NF-κB as a molecular target in adjuvant therapy of gastrointestinal carcinomas. European Journal of Surgical Oncology (EJSO) 31:4, pages 386-392.
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Sheikh Showkat Rahim, Nooruddin Khan, Chandra Sekhar Boddupalli, Seyed E. Hasnain & Sangita Mukhopadhyay. (2005) Interleukin-10 (IL-10) mediated suppression of IL-12 production in RAW 264.7 cells also involves c-rel transcription factor. Immunology 114:3, pages 313-321.
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C Kassed, T Butler & Keith Pennypacker. 2004. Molecular Neurotoxicology. Molecular Neurotoxicology 65 86 .
Thomas D. Gilmore, Daniel T. Starczynowski & Demetrios Kalaitzidis. (2004) RELevant gene amplification in B-cell lymphomas?. Blood 103:8, pages 3243-3245.
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Thomas D Gilmore, Demetrios Kalaitzidis, Mei-Chih Liang & Daniel T Starczynowski. (2004) The c-Rel transcription factor and B-cell proliferation: a deal with the devil. Oncogene 23:13, pages 2275-2286.
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Christopher B Phelps & Gourisankar Ghosh. (2004) Discreet mutations from c-Rel to v-Rel alter κB DNA recognition, IκBα binding, and dimerization: implications for v-Rel oncogenicity. Oncogene 23:6, pages 1229-1238.
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Yongjun Fan, Béatrice Rayet & Céline Gélinas. (2003) Divergent C-terminal transactivation domains of Rel/NF-κB proteins are critical determinants of their oncogenic potential in lymphocytes. Oncogene 23:5, pages 1030-1042.
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Thomas D. Gilmore. 2004. Signal Transduction in Cancer. Signal Transduction in Cancer 241 265 .
Daniel T Starczynowski, Joseph G Reynolds & Thomas D Gilmore. (2003) Deletion of either C-terminal transactivation subdomain enhances the in vitro transforming activity of human transcription factor REL in chicken spleen cells. Oncogene 22:44, pages 6928-6936.
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T. D. Gilmore & G. Mosialos. 2003. Nuclear Factor кB. Nuclear Factor кB 89 113 .
Jarmila Kralova, Andrew S. Liss, William Bargmann, Cullen Pendleton, Janani Varadarajan, Emin Ulug & Henry R. Bose,Jr.Jr.. (2002) Differential Regulation of the Inhibitor of Apoptosis ch-IAP1 by v- rel and the Proto-Oncogene c- rel . Journal of Virology 76:23, pages 11960-11970.
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Ryan A. Cabot, Mark Hannink & Randall S. Prather. (2002) CRM1-Mediated Nuclear Export Is Present During Porcine Embryogenesis, but Is Not Required for Early Cleavage1. Biology of Reproduction 67:3, pages 814-819.
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Isabel Sánchez-Pérez, Salvador Aznar Benitah, Montserrat Martı́nez-Gomariz, Juan Carlos Lacal & Rosario Perona. (2002) Cell Stress and MEKK1-mediated c-Jun Activation Modulate NFκB Activity and Cell Viability. Molecular Biology of the Cell 13:8, pages 2933-2945.
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C.A. Kassed, A.E. Willing, S. Garbuzova-Davis, P.R. Sanberg & K.R. Pennypacker. (2002) Lack of NF-κB p50 Exacerbates Degeneration of Hippocampal Neurons after Chemical Exposure and Impairs Learning. Experimental Neurology 176:2, pages 277-288.
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Andrew S. Liss & Henry R. Bose,Jr.Jr.. (2002) Mutational Analysis of the v-Rel Dimerization Interface Reveals a Critical Role for v-Rel Homodimers in Transformation. Journal of Virology 76:10, pages 4928-4939.
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Su Liu. (2002) Induction of apoptosis by TPA and VP-16 is through translocation of TR3. World Journal of Gastroenterology 8:3, pages 446.
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Sang-Hyun Lee & Mark Hannink. (2001) The N-terminal Nuclear Export Sequence of IκBα Is Required for RanGTP-dependent Binding to CRM1. Journal of Biological Chemistry 276:26, pages 23599-23606.
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Margaret Barkett, Julia E Dooher, Lori Lemonnier, LaVone Simmons, Jennifer N Scarpati, Yuan Wang & Thomas D Gilmore. (2001) Three mutations in v-Rel render it resistant to cleavage by cell-death protease caspase-3. Biochimica et Biophysica Acta (BBA) - General Subjects 1526:1, pages 25-36.
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W. DingS. GaoR.E. Scott. (2001) Senescence represses the nuclear localization of the serum response factor and differentiation regulates its nuclear localization with lineage specificity. Journal of Cell Science 114:5, pages 1011-1018.
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Chia-Huei Lee, Shin C. Chang, C.H.Herbert Wu & Ming-Fu Chang. (2001) A Novel Chromosome Region Maintenance 1-independent Nuclear Export Signal of the Large Form of Hepatitis Delta Antigen That Is Required for the Viral Assembly. Journal of Biological Chemistry 276:11, pages 8142-8148.
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Jean-Charles Epinat, Dickran Kazandjian, Daniel D Harkness, Steven Petros, Jasmine Dave, David W White & Thomas D Gilmore. (2000) Mutant envelope residues confer a transactivation function onto N-terminal sequences of the v-Rel oncoprotein. Oncogene 19:5, pages 599-607.
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Tony T. Huang, Nobuaki Kudo, Minoru Yoshida & Shigeki Miyamoto. (2000) A nuclear export signal in the N-terminal regulatory domain of IκBα controls cytoplasmic localization of inactive NF-κB/IκBα complexes. Proceedings of the National Academy of Sciences 97:3, pages 1014-1019.
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Thomas D Gilmore. (1999) Multiple mutations contribute to the oncogenicity of the retroviral oncoprotein v-Rel. Oncogene 18:49, pages 6925-6937.
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Béatrice Rayet & Céline Gélinas. (1999) Aberrant rel/nfkb genes and activity in human cancer. Oncogene 18:49, pages 6938-6947.
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Rainer de Martin, Johannes A Schmid & Renate Hofer-Warbinek. (1999) The NF-κB/Rel family of transcription factors in oncogenic transformation and apoptosis. Mutation Research/Reviews in Mutation Research 437:3, pages 231-243.
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Mathias Kroll, Florence Margottin, Alain Kohl, Patricia Renard, Hervé Durand, Jean-Paul Concordet, Françoise Bachelerie, Fernando Arenzana-Seisdedos & Richard Benarous. (1999) Inducible Degradation of IκBα by the Proteasome Requires Interaction with the F-box Protein h-βTrCP. Journal of Biological Chemistry 274:12, pages 7941-7945.
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