11
Views
71
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Identification of the In Vivo Casein Kinase II Phosphorylation Site within the Homeodomain of the Cardiac Tisue-Specifying Homeobox Gene Product Csx/Nkx2.5

&
Pages 526-536 | Received 22 Apr 1998, Accepted 17 Sep 1998, Published online: 28 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Xiang Li, Bin Guan, Sam Maghami & Charles J. Bieberich. (2006) NKX3.1 Is Regulated by Protein Kinase CK2 in Prostate Tumor Cells. Molecular and Cellular Biology 26:8, pages 3008-3017.
Read now
Ulka Vijapurkar, Neal Fischbach, Weifang Shen, Christian Brandts, David Stokoe, H. Jeffrey Lawrence & Corey Largman. (2004) Protein Kinase C-Mediated Phosphorylation of the Leukemia-Associated HOXA9 Protein Impairs Its DNA Binding Ability and Induces Myeloid Differentiation. Molecular and Cellular Biology 24:9, pages 3827-3837.
Read now
Hugh N. Nuthall, Junaid Husain, Keith W. McLarren & Stefano Stifani. (2002) Role for Hes1-Induced Phosphorylation in Groucho-Mediated Transcriptional Repression. Molecular and Cellular Biology 22:2, pages 389-399.
Read now

Articles from other publishers (67)

Asma Rafiq, Sabreena Aashaq, Iqra Jan & Mushtaq A. Beigh. (2021) SIX1 transcription factor: A review of cellular functions and regulatory dynamics. International Journal of Biological Macromolecules 193, pages 1151-1164.
Crossref
Ritu Dixit, Chitra Narasimhan, Vijayalakshmi I. Balekundri, Damyanti Agrawal, Ashok Kumar & Bhagyalaxmi Mohapatra. (2021) Functional analysis of novel genetic variants of NKX2 ‐5 associated with nonsyndromic congenital heart disease . American Journal of Medical Genetics Part A 185:12, pages 3644-3663.
Crossref
Wenyu Hu, Anqi Dong, Kohei Karasaki, Shota Sogabe, Daiki Okamoto, Masato Saigo, Mari Ishida, Masao Yoshizumi & Hiroki Kokubo. (2021) Smad4 regulates the nuclear translocation of Nkx2-5 in cardiac differentiation. Scientific Reports 11:1.
Crossref
Nicholas P. Mullin, Joby Varghese, Douglas Colby, Julia M. Richardson, Greg M. Findlay & Ian Chambers. (2020) Phosphorylation of NANOG by casein kinase I regulates embryonic stem cell self‐renewal. FEBS Letters 595:1, pages 14-25.
Crossref
Xiao Lei, Jun Zhao, Jared M. Sagendorf, Niroop Rajashekar, Jiang Xu, Ana Carolina Dantas Machado, Chandani Sen, Remo Rohs, Pinghui Feng & Lin Chen. (2020) Crystal Structures of Ternary Complexes of MEF2 and NKX2–5 Bound to DNA Reveal a Disease Related Protein–Protein Interaction Interface. Journal of Molecular Biology 432:19, pages 5499-5508.
Crossref
Xiuyu Shi, Wenbo Lin, Xiang Gao, Wen Xie, Jeffrey A. GoldenTao Tao. (2020) Identification and validation of the phosphorylation sites on Aristaless-related homeobox protein. Bioscience Reports 40:7.
Crossref
Jorge E. Kolomenski, Marisol Delea, Leandro Simonetti, Mónica C. Fabbro, Lucía D. Espeche, Melisa Taboas, Alejandro D. Nadra, Carlos D. Bruque & Liliana Dain. (2020) An update on genetic variants of the NKX2‐5 . Human Mutation 41:7, pages 1187-1208.
Crossref
Samira Kalayinia, Serwa Ghasemi & Nejat Mahdieh. (2019) A comprehensive in silico analysis, distribution and frequency of human Nkx2-5 mutations; A critical gene in congenital heart disease. Journal of Cardiovascular and Thoracic Research 11:4, pages 287-299.
Crossref
Olivia Moumne, Rajib Chowdhurry, Cassandra Doll, Natalia Pereira, Mustafa Hashimi, Tabor Grindrod, James J. Dollar, Alberto Riva & Hideko Kasahara. (2018) Mechanism Sharing Between Genetic and Gestational Hypoxia-Induced Cardiac Anomalies. Frontiers in Cardiovascular Medicine 5.
Crossref
Abeer F. Zakariyah, Rashida F. Rajgara, Ellias Horner, Marie-Elodie Cattin, Alexandre Blais, Ilona S. Skerjanc & Patrick G. Burgon. (2018) In Vitro Modeling of Congenital Heart Defects Associated with an NKX2-5 Mutation Revealed a Dysregulation in BMP/Notch-Mediated Signaling. Stem Cells 36:4, pages 514-526.
Crossref
Ping Ouyang, He Zhang, Zhaolan Fan, Pei Wei, Zhigang Huang, Sen Wang & Tao Li. (2016) A R/K-rich motif in the C-terminal of the homeodomain is required for complete translocating of NKX2.5 protein into nucleus. Gene 592:2, pages 276-280.
Crossref
Marzieh Armat, Fatemeh Ramezani, Ommoleila Molavi, Mehdi Sabzichi & Nasser Samadi. (2016) Six Family of Homeobox Genes and Related Mechanisms in Tumorigenesis Protocols . Tumori Journal 102:3, pages 236-243.
Crossref
P. C. Dave P. Dingal, Andrew M. Bradshaw, Sangkyun Cho, Matthew Raab, Amnon Buxboim, Joe Swift & Dennis E. Discher. (2015) Fractal heterogeneity in minimal matrix models of scars modulates stiff-niche stem-cell responses via nuclear exit of a mechanorepressor. Nature Materials 14:9, pages 951-960.
Crossref
Romaric Bouveret, Ashley J Waardenberg, Nicole Schonrock, Mirana Ramialison, Tram Doan, Danielle de Jong, Antoine Bondue, Gurpreet Kaur, Stephanie Mohamed, Hananeh Fonoudi, Chiann-mun Chen, Merridee A Wouters, Shoumo Bhattacharya, Nicolas Plachta, Sally L Dunwoodie, Gavin Chapman, Cédric Blanpain & Richard P Harvey. (2015) NKX2-5 mutations causative for congenital heart disease retain functionality and are directed to hundreds of targets. eLife 4.
Crossref
Ossama K. Abou Hassan, Akl C. Fahed, Manal Batrawi, Mariam Arabi, Marwan M. Refaat, Steven R. DePalma, J. G. Seidman, Christine E. Seidman, Fadi F. Bitar & Georges M. Nemer. (2015) NKX2-5 Mutations in an Inbred Consanguineous Population: Genetic and Phenotypic Diversity. Scientific Reports 5:1.
Crossref
Snezana Kojic, Aleksandra Nestorovic, Ljiljana Rakicevic, Olga Protic, Jovana Jasnic-Savovic, Georgine Faulkner & Dragica Radojkovic. (2015) Cardiac transcription factor Nkx2.5 interacts with p53 and modulates its activity. Archives of Biochemistry and Biophysics 569, pages 45-53.
Crossref
Isabel Regadas, Ricardo Soares-dos-Reis, Miguel Falcão, Mariana Raimundo Matos, Filipe Almeida Monteiro, Deolinda Lima & Carlos Reguenga. (2014) Dual role of Tlx3 as modulator of Prrxl1 transcription and phosphorylation. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1839:11, pages 1121-1131.
Crossref
Hongbing Liu, Chao‐Hui Chen, Wenduo Ye, Ramón A. Espinoza‐Lewis, Xuefeng Hu, Yanding Zhang & YiPing Chen. (2014) Phosphorylation of Shox2 Is Required for Its Function to Control Sinoatrial Node Formation. Journal of the American Heart Association 3:3.
Crossref
Ricardo Soares-dos-Reis, Ana S. Pessoa, Mariana R. Matos, Miguel Falcão, Vera M. Mendes, Bruno Manadas, Filipe A. Monteiro, Deolinda Lima & Carlos Reguenga. (2014) Ser119 phosphorylation modulates the activity and conformation of PRRXL1, a homeodomain transcription factor. Biochemical Journal 459:3, pages 441-453.
Crossref
Mauro W. CostaGuanglan GuoOrit WolsteinMolly ValeMaria L. CastroLibin WangRobyn OtwayPeter RiekNatalie CochraneMilena FurtadoChristopher SemsarianRobert G. WeintraubThomas YeohChristopher HaywardAnne KeoghPeter MacdonaldMichael FeneleyRobert M. GrahamJonathan G. SeidmanChristine E. SeidmanNadia RosenthalDiane FatkinRichard P. Harvey. (2013) Functional Characterization of a Novel Mutation in NKX2-5 Associated With Congenital Heart Disease and Adult-Onset Cardiomyopathy . Circulation: Cardiovascular Genetics 6:3, pages 238-247.
Crossref
Lagnajeet Pradhan, Caroli Genis, Peyton Scone, Ellen O. Weinberg, Hideko Kasahara & Hyun-Joo Nam. (2012) Crystal Structure of the Human NKX2.5 Homeodomain in Complex with DNA Target. Biochemistry 51:32, pages 6312-6319.
Crossref
Hoe Suk Kim, Ji Soo Woo, Hyun Jung Joo & Woo Kyung Moon. (2012) Cardiac Transcription Factor Nkx2.5 Is Downregulated under Excessive O-GlcNAcylation Condition. PLoS ONE 7:6, pages e38053.
Crossref
Rami Genead, Helene Fischer, Alamdar Hussain, Marie Jaksch, Agneta B. Andersson, Karin Ljung, Ivana Bulatovic, Anders Franco-Cereceda, Elzafir Elsheikh, Matthias Corbascio, C. I. Edvard Smith, Christer Sylvén & Karl-Henrik Grinnemo. (2012) Ischemia-Reperfusion Injury and Pregnancy Initiate Time-Dependent and Robust Signs of Up-Regulation of Cardiac Progenitor Cells. PLoS ONE 7:5, pages e36804.
Crossref
Mauro W. Costa, Stella Lee, Milena B. Furtado, Li Xin, Duncan B. Sparrow, Camila G. Martinez, Sally L. Dunwoodie, Eleonora Kurtenbach, Tim Mohun, Nadia Rosenthal & Richard P. Harvey. (2011) Complex SUMO-1 Regulation of Cardiac Transcription Factor Nkx2-5. PLoS ONE 6:9, pages e24812.
Crossref
Wenduo Ye, Wenbo Lin, Alan M. Tartakoff & Tao Tao. (2011) Karyopherins in nuclear transport of homeodomain proteins during development. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1813:9, pages 1654-1662.
Crossref
Eun Young Kim, Li Chen, Yanlin Ma, Wei Yu, Jiang Chang, Ivan P. Moskowitz & Jun Wang. (2011) Expression of Sumoylation Deficient Nkx2.5 Mutant in Nkx2.5 Haploinsufficient Mice Leads to Congenital Heart Defects. PLoS ONE 6:6, pages e20803.
Crossref
Varsha K. Khodiyar, David P. Hill, Doug Howe, Tanya Z. Berardini, Susan Tweedie, Philippa J. Talmud, Ross Breckenridge, Shoumo Bhattarcharya, Paul Riley, Peter Scambler & Ruth C. Lovering. (2011) The representation of heart development in the gene ontology. Developmental Biology 354:1, pages 9-17.
Crossref
Wangjun Wu, Zhuqing Ren, Yan Wang, Zhe Chao, Dequan Xu & Yuanzhu Xiong. (2010) Molecular characterization, expression patterns and polymorphism analysis of porcine Six1 gene. Molecular Biology Reports 38:4, pages 2619-2632.
Crossref
Edwin Chen, Xiaoyong Huang, Yanzhen Zheng, You-Jun Li, Alden Chesney, Yaacov Ben-David, Eric Yang & Margaret R Hough. (2010) Phosphorylation of HOX11/TLX1 on Threonine-247 during mitosis modulates expression of cyclin B1. Molecular Cancer 9:1.
Crossref
B Stallmeyer, H Fenge, U Nowak-Göttl & E Schulze-Bahr. (2010) Mutational spectrum in the cardiac transcription factor gene NKX2.5 (CSX) associated with congenital heart disease. Clinical Genetics 78:6, pages 533-540.
Crossref
Jun WangRobert J. Schwartz. (2010) Sumoylation and Regulation of Cardiac Gene Expression. Circulation Research 107:1, pages 19-29.
Crossref
Antonella Cecchetto, Alessandra Rampazzo, Annalisa Angelini,. (2010) From molecular mechanisms of cardiac development to genetic substrate of congenital heart diseases. Future Cardiology 6:3, pages 373-393.
Crossref
David A. Elliott, Edwin P. Kirk, Daniel Schaft & Richard P. Harvey. 2010. Heart Development and Regeneration. Heart Development and Regeneration 569 597 .
Nichole M. McMullen, Feixiong Zhang & Kishore B.S. Pasumarthi. (2009) Assessment of embryonic myocardial cell differentiation using a dual fluorescent reporter system. Journal of Cellular and Molecular Medicine 13:9a, pages 2834-2842.
Crossref
Abdenour Soufi, Peter Noy, Malcolm Buckle, Anyaporn Sawasdichai, Kevin Gaston & Padma-Sheela Jayaraman. (2009) CK2 phosphorylation of the PRH/Hex homeodomain functions as a reversible switch for DNA binding. Nucleic Acids Research 37:10, pages 3288-3300.
Crossref
Markella Ponticos. 2010. Advances in Vascular Medicine. Advances in Vascular Medicine 113 130 .
Jun Wang, Hua Zhang, Dinakar Iyer, Xin-Hua Feng & Robert J. Schwartz. (2008) Regulation of Cardiac Specific nkx2.5 Gene Activity by Small Ubiquitin-like Modifier. Journal of Biological Chemistry 283:34, pages 23235-23243.
Crossref
Martje Toenjes, Markus Schueler, Stefanie Hammer, Utz J. Pape, Jenny J. Fischer, Felix Berger, Martin Vingron & Silke Sperling. (2008) Prediction of cardiac transcription networks based on molecular data and complex clinical phenotypes. Molecular BioSystems 4:6, pages 589.
Crossref
Radwan Abu-IssaMargaret L. Kirby. (2007) Heart Field: From Mesoderm to Heart Tube. Annual Review of Cell and Developmental Biology 23:1, pages 45-68.
Crossref
Tao Li, Yan-Ming Li, Zhu-Qing Jia, Ping Chen, Kang-Tao Ma & Chun-Yan Zhou. (2007) Carboxyl Terminus of NKX2.5 Impairs its Interaction with p300. Journal of Molecular Biology 370:5, pages 976-992.
Crossref
Yun-Zi Chen, Hua Ying, Jing Zhang, Wei Cheng, Yuan-Xi Kang & Zi-Chun Hua. (2007) Biochemical Analyses of Csx/Nkx2.5 Mutants and Their Structure–Function Relationship. International Journal of Molecular Sciences 8:4, pages 284-294.
Crossref
Carmen Perez-Terzic, Randolph S Faustino, Brian J Boorsma, D Kent Arrell, Nicolas J Niederländer, Atta Behfar & Andre Terzic. (2007) Stem cells transform into a cardiac phenotype with remodeling of the nuclear transport machinery. Nature Clinical Practice Cardiovascular Medicine 4:S1, pages S68-S76.
Crossref
Takayo Ota, Kyung-Bok Choi, C. Blake Gilks, Peter C.K. Leung & Nelly Auersperg. (2006) Cell type- and stage-specific changes in HOXA7 protein expression in human ovarian folliculogenesis: possible role of GDF-9. Differentiation 74:1, pages 1-10.
Crossref
Antonio Marchini, Laurent Daeffler, Tiina Marttila, Katja U. Schneider, Rüdiger J. Blaschke, Martina Schnölzer, Jean Rommelaere & Gudrun Rappold. (2006) Phosphorylation on Ser106 Modulates the Cellular Functions of the SHOX Homeodomain Protein. Journal of Molecular Biology 355:3, pages 590-603.
Crossref
Hiroshi Akazawa & Issei Komuro. (2005) Cardiac transcription factor Csx/Nkx2-5: Its role in cardiac development and diseases. Pharmacology & Therapeutics 107:2, pages 252-268.
Crossref
Stefan Nagel, Maren Kaufmann, Michaela Scherr, Hans G. Drexler & Roderick A. F. MacLeod. (2005) Activation ofHLXB9 by juxtaposition withMYB via formation of t(6;7)(q23;q36) in an AML-M4 cell line (GDM-1). Genes, Chromosomes and Cancer 42:2, pages 170-178.
Crossref
Brad A. AmendtBrad A. Amendt. 2005. The Molecular Mechanisms of Axenfeld-Rieger Syndrome. The Molecular Mechanisms of Axenfeld-Rieger Syndrome 32 53 .
Antonio Marchini, Tiina Marttila, Anja Winter, Sandra Caldeira, Ilaria Malanchi, Rüdiger J. Blaschke, Beate Häcker, Ercole Rao, Marcel Karperien, Jan M. Wit, Wiltrud Richter, Massimo Tommasino & Gudrun A. Rappold. (2004) The Short Stature Homeodomain Protein SHOX Induces Cellular Growth Arrest and Apoptosis and Is Expressed in Human Growth Plate Chondrocytes. Journal of Biological Chemistry 279:35, pages 37103-37114.
Crossref
Majbrit Hjerrild, Allan Stensballe, Ole N Jensen, Steen Gammeltoft & Thomas E Rasmussen. (2004) Protein kinase A phosphorylates serine 267 in the homeodomain of engrailed-2 leading to decreased DNA binding. FEBS Letters 568:1-3, pages 55-59.
Crossref
Stella Marie Reamon-Buettner, Hartmut Hecker, Katharina Spanel-Borowski, Steffen Craatz, Eberhard Kuenzel & Juergen Borlak. (2004) Novel NKX2–5 Mutations in Diseased Heart Tissues of Patients with Cardiac Malformations. The American Journal of Pathology 164:6, pages 2117-2125.
Crossref
Sandra L Schwindling, Andreas Noll, Mathias Montenarh & Claudia Götz. (2004) Mutation of a CK2 phosphorylation site in cdc25C impairs importin α/β binding and results in cytoplasmic retention. Oncogene 23:23, pages 4155-4165.
Crossref
Hiroko Wakimoto, Hideko Kasahara, Colin T. Maguire, Ivan P.G. Moskowitz, Seigo Izumo & Charles I. Berul. (2003) Cardiac electrophysiological phenotypes in postnatal expression of Nkx2.5 transgenic mice. genesis 37:3, pages 144-150.
Crossref
Flavio Meggio & Lorenzo A. Pinna. (2003) One‐thousand‐and‐one substrates of protein kinase CK2?. The FASEB Journal 17:3, pages 349-368.
Crossref
Akiko Obinata, Yoshihiro Akimoto, Yasumasa Omoto & Hiroshi Hirano. (2002) Expression of Hex homeobox gene during skin development: Increase in epidermal cell proliferation by transfecting the Hex to the dermis. Development, Growth and Differentiation 44:4, pages 281-292.
Crossref
Megumi Adachi & Elaine J. Lewis. (2002) The Paired-like Homeodomain Protein, Arix, Mediates Protein Kinase A-stimulated Dopamine β-Hydroxylase Gene Transcription through Its Phosphorylation Status. Journal of Biological Chemistry 277:25, pages 22915-22924.
Crossref
Benoit G. Bruneau. (2002) Transcriptional Regulation of Vertebrate Cardiac Morphogenesis. Circulation Research 90:5, pages 509-519.
Crossref
Yuichi Ikeda, Yukio Hiroi, Toru Hosoda, Toshinori Utsunomiya, Shuzo Matsuo, Tsuyoshi Ito, Jun-ichi Inoue, Tetsuya Sumiyoshi, Hiroyuki Takano, Ryozo Nagai & Issei Komuro. (2002) Novel Point Mutation in the Cardiac Transcription Factor CSX/NKX2.5 Associated With Congenital Heart Disease.. Circulation Journal 66:6, pages 561-563.
Crossref
R.P. HARVEY, D. LAI, D. ELLIOTT, C. BIBEN, M. SOLLOWAY, O. PRALL, F. STENNARD, A. SCHINDELER, N. GROVES, L. LAVULO, C. HYUN, T. YEOH, M. COSTA, M. FURTADO & E. KIRK. (2002) Homeodomain Factor Nkx2-5 in Heart Development and Disease. Cold Spring Harbor Symposia on Quantitative Biology 67:0, pages 107-114.
Crossref
Hideko Kasahara, Hiroko Wakimoto, Margaret Liu, Colin T. Maguire, Kimber L. Converso, Tetsuo Shioi, Weei-Yuarn Huang, Warren J. Manning, David Paul, Joel Lawitts, Charles I. Berul & Seigo Izumo. (2001) Progressive atrioventricular conduction defects and heart failure in mice expressing a mutant Csx/Nkx2.5 homeoprotein. Journal of Clinical Investigation 108:2, pages 189-201.
Crossref
Geon Tae Park, Mitchell F. Denning & Maria I. Morasso. (2001) Phosphorylation of murine homeodomain protein Dlx3 by protein kinase C. FEBS Letters 496:1, pages 60-65.
Crossref
Hideko Kasahara, Anny Usheva, Tomomi Ueyama, Hiroki Aoki, Nobuo Horikoshi & Seigo Izumo. (2001) Characterization of Homo- and Heterodimerization of Cardiac Csx/Nkx2.5 Homeoprotein. Journal of Biological Chemistry 276:7, pages 4570-4580.
Crossref
J.T. BryanM.I. Morasso. (2000) The Dlx3 protein harbors basic residues required for nuclear localization, transcriptional activity and binding to Msx1. Journal of Cell Science 113:22, pages 4013-4023.
Crossref
Diane H. Song, Daniel J. Sussman & David C. Seldin. (2000) Endogenous Protein Kinase CK2 Participates in Wnt Signaling in Mammary Epithelial Cells. Journal of Biological Chemistry 275:31, pages 23790-23797.
Crossref
Hideko Kasahara, Bora Lee, Jean-Jacques Schott, D. Woodrow Benson, J.G. Seidman, Christine E. Seidman & Seigo Izumo. (2000) Loss of function and inhibitory effects of human CSX/NKX2.5 homeoprotein mutations associated with congenital heart disease. Journal of Clinical Investigation 106:2, pages 299-308.
Crossref
Heide L. Ford, Esther Landesman-Bollag, Caroline S. Dacwag, P.Todd Stukenberg, Arthur B. Pardee & David C. Seldin. (2000) Cell Cycle-regulated Phosphorylation of the Human SIX1 Homeodomain Protein. Journal of Biological Chemistry 275:29, pages 22245-22254.
Crossref
D. Woodrow Benson, G. Michael Silberbach, Ann Kavanaugh-McHugh, Carol Cottrill, Yizhong Zhang, Steve Riggs, Octavia Smalls, Mark C. Johnson, Michael S. Watson, J.G. Seidman, Christine E. Seidman, John Plowden & John D. Kugler. (1999) Mutations in the cardiac transcription factor NKX2.5 affect diverse cardiac developmental pathways. Journal of Clinical Investigation 104:11, pages 1567-1573.
Crossref
Mingfa Li, Dennis Strand, Andreas Krehan, Walter Pyerin, Hans Heid, Beate Neumann & Bernard M. Mechler. (1999) Casein kinase 2 binds and phosphorylates the nucleosome assembly protein-1 (NAP1) in Drosophila melanogaster 1 1Edited by M. Yaniv. Journal of Molecular Biology 293:5, pages 1067-1084.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.