Advanced search
Publication Cover
Molecular and Cellular Biology Volume 19, 1999 - Issue 1
Submit an article Journal homepage
11
Views
52
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Human Osteogenesis Involves Differentiation-Dependent Increases in the Morphogenically Active 3′ Alternative Splicing Variant of Acetylcholinesterase

Dan Grisaru1 Department of Biological Chemistry, Life Sciences Institute, The Hebrew University of Jerusalem, Jerusalem91904;2 Departments of Obstetrics and Gynecology;3 Hematology, Tel-Aviv Sourasky Medical Center, The Sackler School of Medicine, Tel-Aviv University, Tel-Aviv64239, Israel
,
Efrat Lev-Lehman1 Department of Biological Chemistry, Life Sciences Institute, The Hebrew University of Jerusalem, Jerusalem91904
,
Michael Shapira1 Department of Biological Chemistry, Life Sciences Institute, The Hebrew University of Jerusalem, Jerusalem91904
,
Ellen Chaikin1 Department of Biological Chemistry, Life Sciences Institute, The Hebrew University of Jerusalem, Jerusalem91904
,
Joseph B. Lessing2 Departments of Obstetrics and Gynecology
,
Amiram Eldor3 Hematology, Tel-Aviv Sourasky Medical Center, The Sackler School of Medicine, Tel-Aviv University, Tel-Aviv64239, Israel
,
Fritz Eckstein4 Max-Planck-Institut für Experimentelle Medizin, D-37075Göttingen, Germany
&
Hermona Soreq1 Department of Biological Chemistry, Life Sciences Institute, The Hebrew University of Jerusalem, Jerusalem91904Correspondence[email protected]
 show all
Pages 788-795 | Received 15 May 1998, Accepted 21 Sep 1998, Published online: 28 Mar 2023

Citations (52)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Xiaoming Su, Jianxun Zhang, Yinlong Guo & Qidong Zhang. (2012) Study of Effects of Cigarette Smoke Condensates on Acetylcholinesterase Activity in Human Lung Epithelial Cells by Matrix-Assisted Laser Desorption/Ionization-Fourier Transform Mass Spectrometry. Analytical Letters 45:18, pages 2687-2696.
Read now

Articles from other publishers (51)

Israel Silman. (2021) The multiple biological roles of the cholinesterases. Progress in Biophysics and Molecular Biology 162, pages 41-56.
Crossref
Vidyani Suryadevara, Michael Klüppel, Federica del Monte & Monte S. Willis. (2020) The Unraveling. The American Journal of Pathology 190:8, pages 1609-1621.
Crossref
Janine Spieker, Johannes L. Frieß, Laura Sperling, Gopenath Thangaraj, Astrid Vogel-Höpker & Paul G. Layer. (2020) Cholinergic control of bone development and beyond. International Immunopharmacology 83, pages 106405.
Crossref
Raj Kumar Chinnadurai, Ponne Saravanaraman & Rathanam Boopathy. (2017) The significance of aryl acylamidase activity of acetylcholinesterase in osteoblast differentiation and mineralization. Molecular and Cellular Biochemistry 440:1-2, pages 199-208.
Crossref
Ramona WeistThilo FlörkemeierYvonne RogerSandra NoackAnnika FrankeKristin SchwankeRobert ZweigerdtUlrich MartinElmar WillboldAndrea Hoffmann. (2018) Differential Expression of Cholinergic System Components in Human Induced Pluripotent Stem Cells, Bone Marrow-Derived Multipotent Stromal Cells, and Induced Pluripotent Stem Cell-Derived Multipotent Stromal Cells. Stem Cells and Development 27:3, pages 166-183.
Crossref
Miranda L. Xu, Cathy W.C. Bi, Etta Y.L. Liu, Tina T.X. Dong & Karl W.K. Tsim. (2017) Wnt3a induces the expression of acetylcholinesterase during osteoblast differentiation via the Runx2 transcription factor. Journal of Biological Chemistry 292:30, pages 12667-12678.
Crossref
Amber M. Prugh, Stephanie D. Cole, Trevor Glaros & Daniel J. Angelini. (2017) Effects of organophosphates on the regulation of mesenchymal stem cell proliferation and differentiation. Chemico-Biological Interactions 266, pages 38-46.
Crossref
Janine Spieker, Thomas Mudersbach, Astrid Vogel-Höpker & Paul G. Layer. (2017) Endochondral Ossification Is Accelerated in Cholinesterase-Deficient Mice and in Avian Mesenchymal Micromass Cultures. PLOS ONE 12:1, pages e0170252.
Crossref
Melissa A. Pickett, Michael K. Dush & Nanette M. Nascone-Yoder. (2017) Acetylcholinesterase plays a non-neuronal, non-esterase role in organogenesis. Development.
Crossref
Gopenath Thangaraj, Vadim Manakov, Aljona Cucu, Claudia Fournier & Paul G. Layer. (2016) Inflammatory effects of TNFα are counteracted by X-ray irradiation and AChE inhibition in mouse micromass cultures. Chemico-Biological Interactions 259, pages 313-318.
Crossref
Miranda L. Xu, Cathy W.C. Bi, Ava Y.Y. Kong, Tina T.X. Dong, Yung H. Wong & Karl W.K. Tsim. (2016) Flavonoids induce the expression of acetylcholinesterase in cultured osteoblasts. Chemico-Biological Interactions 259, pages 295-300.
Crossref
Janine Spieker, Anica Ackermann, Anika Salfelder, Astrid Vogel-Höpker & Paul G. Layer. (2016) Acetylcholinesterase Regulates Skeletal In Ovo Development of Chicken Limbs by ACh-Dependent and -Independent Mechanisms. PLOS ONE 11:8, pages e0161675.
Crossref
Malte Haupt, Vivien Kauschke, Jonas Sender, Marian Kampschulte, Anna Kovtun, Lutz Dürselen, Christian Heiss & Katrin Susanne Lips. (2015) Bone status of adult female butyrylcholinesterase gene-deficient mice. International Immunopharmacology 29:1, pages 208-214.
Crossref
Tsuyoshi Sato, Yuichiro Enoki, Yasushi Sakamoto, Kazuhiro Yokota, Masahiko Okubo, Masahito Matsumoto, Naoki Hayashi, Michihiko Usui, Shoichiro Kokabu, Toshihide Mimura, Yoshihiko Nakazato, Nobuo Araki, Toru Fukuda, Yasushi Okazaki, Tatsuo Suda, Shu Takeda & Tetsuya Yoda. (2015) Donepezil prevents RANK-induced bone loss via inhibition of osteoclast differentiation by downregulating acetylcholinesterase. Heliyon 1:1, pages e00013.
Crossref
Hana Chovancová, Radoslav Omelka, Ivana Boboňová, Grzegorz Formicki, Róbert Toman & Monika Martiniaková. (2014) Bone adaptation to simultaneous cadmium and diazinon toxicity in adult male rats. Potravinarstvo Slovak Journal of Food Sciences 8:1, pages 107-113.
Crossref
Yuanyuan Ma, Xianxian Li, Jing Fu, Yue Li, Li Gao, Ling Yang, Ping Zhang, Jiefei Shen & Hang Wang. (2014) Acetylcholine affects osteocytic MLO-Y4 cells via acetylcholine receptors. Molecular and Cellular Endocrinology 384:1-2, pages 155-164.
Crossref
Monika Martiniaková, Ivana Boboňová, Radoslav Omelka, Birgit Grosskopf, Hana Chovancová, Jana Španková & Róbert Toman. (2013) Simultaneous subchronic exposure to selenium and diazinon as possible risk factor for osteoporosis in adult male rats. Acta Veterinaria Scandinavica 55:1.
Crossref
Paul G. Layer, Janine Klaczinski, Anika Salfelder, Laura E. Sperling, Gopenath Thangaraj, Corina Tuschl & Astrid Vogel-Höpker. (2013) Cholinesterases in development: AChE as a firewall to inhibit cell proliferation and support differentiation. Chemico-Biological Interactions 203:1, pages 269-276.
Crossref
Pei-Shan Liu, Yi-Yin Chen, Chi-Kuang Feng, Yi-Hsuan Lin & Tien-Chi Yu. (2011) Muscarinic acetylcholine receptors present in human osteoblast and bone tissue. European Journal of Pharmacology 650:1, pages 34-40.
Crossref
T.L. Nandasena, C.K. Jayawardena, W.M. Tilakaratne & C.D. Nanayakkara. (2010) Distribution pattern of cholinesterase enzymes in human tooth germs. Archives of Oral Biology 55:8, pages 561-569.
Crossref
Tsuyoshi Sato, Takahiro Abe, Dai Chida, Norimichi Nakamoto, Naoko Hori, Shoichiro Kokabu, Yasuaki Sakata, Yasuhisa Tomaru, Takanori Iwata, Michihiko Usui, Katsuya Aiko & Tetsuya Yoda. (2010) Functional role of acetylcholine and the expression of cholinergic receptors and components in osteoblasts. FEBS Letters 584:4, pages 817-824.
Crossref
Marianne J. Ellis, Richard Forsey & Julian B. Chaudhuri. (2009) Post-culture treatment protocols for PLGA membrane scaffolds. Biotechnology Letters 32:2, pages 215-222.
Crossref
Sang Eun Park & Young Hyun Yoo. 2010. Apoptosome. Apoptosome 221 236 .
Maryam En-Nosse, Sonja Hartmann, Katja Trinkaus, Volker Alt, Brigitte Stigler, Christian Heiss, Olaf Kilian, Reinhard Schnettler & Katrin Susanne Lips. (2009) Expression of non-neuronal cholinergic system in osteoblast-like cells and its involvement in osteogenesis. Cell and Tissue Research 338:2, pages 203-215.
Crossref
Joana C. Costa, Catherine J. Lilley, Howard J. Atkinson & Peter E. Urwin. (2009) Functional characterisation of a cyst nematode acetylcholinesterase gene using Caenorhabditis elegans as a heterologous system. International Journal for Parasitology 39:7, pages 849-858.
Crossref
Brian C. Geyer, Tama Evron, Hermona Soreq & Tsafrir S. Mor. 2009. Handbook of Toxicology of Chemical Warfare Agents. Handbook of Toxicology of Chemical Warfare Agents 691 717 .
Adi Gilboa-GeffenPaul P. Lacoste, Lilach SoreqGeraldine Cizeron-Clairac, Rozen Le PanseFrederique Truffault, Iftach ShakedHermona SoreqSonia Berrih-Aknin. (2007) The thymic theme of acetylcholinesterase splice variants in myasthenia gravis. Blood 109:10, pages 4383-4391.
Crossref
Dan Grisaru, Ran Keidar, Letizia Schreiber, Joseph B. Lessing & Varda Deutsch. (2007) The effect of the readthrough acetylcholinesterase variant (AChE-R) on uterine muscle and leiomyomas. MHR: Basic science of reproductive medicine 13:5, pages 351-354.
Crossref
Martin J. Hoogduijn, Zoltan Rakonczay & Paul G. Genever. (2006) The Effects of Anticholinergic Insecticides on Human Mesenchymal Stem Cells. Toxicological Sciences 94:2, pages 342-350.
Crossref
Gabriel Zimmerman & Hermona Soreq. (2006) Termination and beyond: acetylcholinesterase as a modulator of synaptic transmission. Cell and Tissue Research 326:2, pages 655-669.
Crossref
A. DORI & H. SOREQ. (2006) Neuromuscular Therapeutics by RNA-Targeted Suppression of ACHE Gene Expression. Annals of the New York Academy of Sciences 1082:1, pages 77-90.
Crossref
Cecilio J. Vidal. (2005) Expression of cholinesterases in brain and non-brain tumours. Chemico-Biological Interactions 157-158, pages 227-232.
Crossref
Jean Massoulié, Suzanne Bon, Noël Perrier & Cinzia Falasca. (2005) The C-terminal peptides of acetylcholinesterase: Cellular trafficking, oligomerization and functional anchoring. Chemico-Biological Interactions 157-158, pages 3-14.
Crossref
Bryan F. Curtin, Lauren M. Tetz, Jaimee R. Compton, Bhupendra P. Doctor, Richard K. Gordon & Madhusoodana P. Nambiar. (2005) Histone acetylase inhibitor trichostatin A induces acetylcholinesterase expression and protects against organophosphate exposure. Journal of Cellular Biochemistry 96:4, pages 839-849.
Crossref
Colette A. Inkson, Alex C. Brabbs, Tarlochan S. Grewal, Timothy M. Skerry & Paul G. Genever. (2004) Characterization of acetylcholinesterase expression and secretion during osteoblast differentiation. Bone 35:4, pages 819-827.
Crossref
Chava Perry, Ella H. Sklan & Hermona Soreq. (2004) CREB Regulates AChE-R-Induced Proliferation of Human Glioblastoma Cells. Neoplasia 6:3, pages 279-286.
Crossref
Gary J Spencer, Ian S Hitchcock & Paul G Genever. (2004) Emerging neuroskeletal signalling pathways: a review. FEBS Letters 559:1-3, pages 6-12.
Crossref
Chava Perry, Ella H Sklan, Klara Birikh, Michael Shapira, Leonor Trejo, Amiram Eldor & Hermona Soreq. (2002) Complex regulation of acetylcholinesterase gene expression in human brain tumors. Oncogene 21:55, pages 8428-8441.
Crossref
Varda R Deutsch, Marjorie Pick, Chava Perry, Dan Grisaru, Yoram Hemo, Dita Golan-Hadari, Alastair Grant, Amiram Eldor & Hermona Soreq. (2002) The stress-associated acetylcholinesterase variant AChE-R is expressed in human CD34+ hematopoietic progenitors and its C-terminal peptide ARP promotes their proliferation. Experimental Hematology 30:10, pages 1153-1161.
Crossref
Chava Perry & Hermona Soreq. (2002) Transcriptional regulation of erythropoiesis. European Journal of Biochemistry 269:15, pages 3607-3618.
Crossref
Francisco Ruiz-Espejo, Juan Cabezas-Herrera, Julián Illana, Francisco J. Campoy & Cecilio J. Vidal. (2002) Cholinesterase Activity and Acetylcholinesterase Glycosylation are Altered in Human Breast Cancer. Breast Cancer Research and Treatment 72:1, pages 11-22.
Crossref
Chava Perry, Amiram Eldor & Hermona Soreq. (2002) Runx1/AML1 in leukemia: disrupted association with diverse protein partners. Leukemia Research 26:3, pages 221-228.
Crossref
Inbal Mor, Dan Grisaru, Lior Titelbaum, Tamah Evron, Carmelit Richler, Jacob Wahrman, Meira Sternfeld, Leah Yogev, Noam Meiri, Shlomo Seidman & Hermona Soreq. (2001) Modified testicular expression of stress‐associated “readthrough” acetylcholinesterase predicts male infertility. The FASEB Journal 15:11, pages 2039-2041.
Crossref
Hermona Soreq & Shlomo Seidman. (2001) Acetylcholinesterase — new roles for an old actor. Nature Reviews Neuroscience 2:4, pages 294-302.
Crossref
Katsunori Nakano & Karen H Vousden. (2001) PUMA, a Novel Proapoptotic Gene, Is Induced by p53. Molecular Cell 7:3, pages 683-694.
Crossref
N. GalyamD. GrisaruM. GrifmanN. Melamed-BookF. EcksteinS. SeidmanA. EldorH. Soreq. (2001) Complex Host Cell Responses to Antisense Suppression of ACHE Gene Expression . Antisense and Nucleic Acid Drug Development 11:1, pages 51-57.
Crossref
Dan Grisaru, Varda Deutsch, Michael Shapira, Marjorie Pick, Meira Sternfeld, Naomi Melamed-Book, Daniela Kaufer, Nilly Galyam, Michael J. Gait, David Owen, Joseph B. Lessing, Amiram Eldor & Hermona Soreq. (2001) ARP, A Peptide Derived from the Stress-Associated Acetylcholinesterase Variant, Has Hematopoietic Growth Promoting Activities. Molecular Medicine 7:2, pages 93-105.
Crossref
JE Compston, S Vedi, AB Stephen, S Bord, AR Lyons, SJ Hodges & BE Scammell. (1999) Reduced bone formation after exposure to organophosphates. The Lancet 354:9192, pages 1791-1792.
Crossref
Dan Grisaru, Meira Sternfeld, Amiram Eldor, David Glick & Hermona Soreq. (1999) Structural roles of acetylcholinesterase variants in biology and pathology. European Journal of Biochemistry 264:3, pages 672-686.
Crossref
SHLOMO SEIDMAN, FRITZ ECKSTEIN, MIRTA GRIFMAN & HERMONA SOREQ. (1999) Antisense Technologies Have a Future Fighting Neurodegenerative Diseases. Antisense and Nucleic Acid Drug Development 9:4, pages 333-340.
Crossref
Ron S Broide, Mirta Grifman, Anat Loewenstein, Dan Grisaru, Rina Timberg, Jonathan Stone, Moshe Shani, James W Patrick & Hermona Soreq. (1999) Manipulations of ACHE gene expression suggest non-catalytic involvement of acetylcholinesterase in the functioning of mammalian photoreceptors but not in retinal degeneration. Molecular Brain Research 71:2, pages 137-148.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.