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Molecular and Cellular Biology Volume 19, 1999 - Issue 11
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Mammalian Genetic Models with Minimal or Complex Phenotypes

Targeted Disruption of the Murine fps/fes Proto-Oncogene Reveals that Fps/Fes Kinase Activity Is Dispensable for Hematopoiesis

Yotis Senis1 Department of Pathology
,
Ralph Zirngibl2 Department of Biochemistry, Cancer Research Laboratories, Queen’s University, Kingston, OntarioK7L 3N6
,
Jennifer McVeigh1 Department of Pathology
,
Andre Haman3 Laboratory of Hemopoiesis and Leukemia, Institut de Recherches Cliniques de Montreal, Montreal, QuebecH2W 1R7, Canada
,
Trang Hoang3 Laboratory of Hemopoiesis and Leukemia, Institut de Recherches Cliniques de Montreal, Montreal, QuebecH2W 1R7, Canada
&
Peter A. Greer1 Department of Pathology;2 Department of Biochemistry, Cancer Research Laboratories, Queen’s University, Kingston, OntarioK7L 3N6Correspondence[email protected]
Pages 7436-7446 | Received 02 Aug 1999, Accepted 05 Aug 1999, Published online: 28 Mar 2023

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Andrew W. B. Craig & Peter A. Greer. (2002) Fer Kinase Is Required for Sustained p38 Kinase Activation and Maximal Chemotaxis of Activated Mast Cells. Molecular and Cellular Biology 22:18, pages 6363-6374.
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Ralph A. Zirngibl, Yotis Senis & Peter A. Greer. (2002) Enhanced Endotoxin Sensitivity in Fps/Fes-Null Mice with Minimal Defects in Hematopoietic Homeostasis. Molecular and Cellular Biology 22:8, pages 2472-2486.
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Jynho Kim & Ricardo A. Feldman. (2002) Activated Fes Protein Tyrosine Kinase Induces Terminal Macrophage Differentiation of Myeloid Progenitors (U937 Cells) and Activation of the Transcription Factor PU.1. Molecular and Cellular Biology 22:6, pages 1903-1918.
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Haiyun Y. Cheng, Anthony P. Schiavone & Thomas E. Smithgall. (2001) A Point Mutation in the N-Terminal Coiled-Coil Domain Releases c-Fes Tyrosine Kinase Activity and Survival Signaling in Myeloid Leukemia Cells. Molecular and Cellular Biology 21:18, pages 6170-6180.
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Andrew W. B. Craig, Ralph Zirngibl, Karen Williams, Lesley-Ann Cole & Peter A. Greer. (2001) Mice Devoid of Fer Protein-Tyrosine Kinase Activity Are Viable and Fertile but Display Reduced Cortactin Phosphorylation. Molecular and Cellular Biology 21:2, pages 603-613.
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Articles from other publishers (32)

Thomas E. Smithgall. 2021. Encyclopedia of Biological Chemistry III. Encyclopedia of Biological Chemistry III 358 363 .
Tom van der Wel, Riet Hilhorst, Hans den Dulk, Tim van den Hooven, Nienke M. Prins, Joost A. P. M. Wijnakker, Bogdan I. Florea, Eelke B. Lenselink, Gerard J. P. van Westen, Rob Ruijtenbeek, Herman S. Overkleeft, Allard Kaptein, Tjeerd Barf & Mario van der Stelt. (2020) Chemical genetics strategy to profile kinase target engagement reveals role of FES in neutrophil phagocytosis. Nature Communications 11:1.
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Jinhang Hu, Lufeng Zheng, Xiao Shen, Yan Zhang, Cheng Li & Tao Xi. (2017) MicroRNA-125b inhibits AML cells differentiation by directly targeting Fes. Gene 620, pages 1-9.
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Shengnan Zhang, Violeta Chitu, E. Richard Stanley, Bruce E. Elliott & Peter A. Greer. (2011) Fes Tyrosine Kinase Expression in the Tumor Niche Correlates with Enhanced Tumor Growth, Angiogenesis, Circulating Tumor Cells, Metastasis, and Infiltrating Macrophages. Cancer Research 71:4, pages 1465-1473.
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Peter F. Truesdell, Ralph A. Zirngibl, Sarah Francis, Waheed Sangrar & Peter A. Greer. (2009) fps/fes knockout mice display a lactation defect and the fps/fes tyrosine kinase is a component of E-cadherin-based adherens junctions in breast epithelial cells during lactation. Experimental Cell Research 315:17, pages 2929-2940.
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Zoya Shapovalova, Kyrylo Tabunshchyk & Peter A Greer. (2007) The Fer tyrosine kinase regulates an axon retraction response to Semaphorin 3A in dorsal root ganglion neurons. BMC Developmental Biology 7:1.
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Edwige Voisset, Sophie Lopez, Patrice Dubreuil & Paulo De Sepulveda. (2007) The tyrosine kinase FES is an essential effector of KITD816V proliferation signal. Blood 110:7, pages 2593-2599.
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Frank J. DelfinoJonathan M. ShafferThomas E. Smithgall. (2006) The KRAB-associated co-repressor KAP-1 is a coiled-coil binding partner, substrate and activator of the c-Fes protein tyrosine kinase. Biochemical Journal 399:1, pages 141-150.
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Sean A Parsons & Peter A Greer. (2006) The Fps/Fes kinase regulates the inflammatory response to endotoxin through down-regulation of TLR4, NF-κB activation, and TNF-α secretion in macrophages. Journal of Leukocyte Biology 80:6, pages 1522-1528.
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Christian M. Udell, Lionel A. Samayawardhena, Yuko Kawakami, Toshiaki Kawakami & Andrew W.B. Craig. (2006) Fer and Fps/Fes Participate in a Lyn-dependent Pathway from FcϵRI to Platelet-Endothelial Cell Adhesion Molecule 1 to Limit Mast Cell Activation. Journal of Biological Chemistry 281:30, pages 20949-20957.
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Yinfei Tan, Nathalie Dourdin, Chao Wu, Teresa De Veyra, John S. Elce & Peter A. Greer. (2006) Conditional disruption of ubiquitous calpains in the mouse. genesis 44:6, pages 297-303.
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Waheed Sangrar, Ralph A. Zirgnibl, Yan Gao, William J. Muller, Zongchao Jia & Peter A. Greer. (2005) An Identity Crisis for fps/fes : Oncogene or Tumor Suppressor? . Cancer Research 65:9, pages 3518-3522.
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Anne CarlsonJeanne Mcadara BerkowitzDamaris BrowningDennis J. SlamonJudith C. GassonKaren E. Yates. (2005) Expression of c-Fes Protein Isoforms Correlates with Differentiation in Myeloid Leukemias. DNA and Cell Biology 24:5, pages 311-316.
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W. Sangrar, Y. Senis, J.A. Samis, Y. Gao, M. Richardson, D.H. Lee & P.A. Greer. (2004) Hemostatic and hematological abnormalities in gain‐of‐function fps/fes transgenic mice are associated with the angiogenic phenotype. Journal of Thrombosis and Haemostasis 2:11, pages 2009-2019.
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Waheed Sangrar, Yan Gao, Barbara Bates, Ralph Zirngibl & Peter A. Greer. (2004) Activated Fps/Fes tyrosine kinase regulates erythroid differentiation and survival. Experimental Hematology 32:10, pages 935-945.
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W. Sangrar, J.D. Mewburn, S.G. Vincent, J.T. Fisher & P.A. Greer. (2004) Vascular defects in gain‐of‐function fps/festransgenic mice correlate with PDGF‐ and VEGF‐induced activation of mutant Fps/Fes kinase in endothelial cells. Journal of Thrombosis and Haemostasis 2:5, pages 820-832.
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Waheed Sangrar, Yan Gao, Ralph A Zirngibl, Michelle L Scott & Peter A Greer. (2003) The fps/fes proto-oncogene regulates hematopoietic lineage output. Experimental Hematology 31:12, pages 1259-1267.
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Yotis A Senis, Andrew W.B Craig & Peter A Greer. (2003) Fps/Fes and Fer protein-tyrosinekinases play redundant roles in regulating hematopoiesis. Experimental Hematology 31:8, pages 673-681.
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Y.A. Senis, W. Sangrar, R.A. Zirngibl, A.W.B. Craig, D.H. Lee & P.A. Greer. (2003) Fps/Fes and Fer non-receptor protein-tyrosine kinases regulate collagen- and ADP-induced platelet aggregation. Journal of Thrombosis and Haemostasis 1:5, pages 1062-1070.
Crossref
Donna-Marie McCafferty, Andrew W. B. Craig, Yotis A. Senis & Peter A. Greer. (2002) Absence of Fer Protein-Tyrosine Kinase Exacerbates Leukocyte Recruitment in Response to Endotoxin. The Journal of Immunology 168:10, pages 4930-4935.
Crossref
Renee Hackenmiller & M.Celeste Simon. (2002) Truncation of c-fes via Gene Targeting Results in Embryonic Lethality and Hyperproliferation of Hematopoietic Cells. Developmental Biology 245:2, pages 255-269.
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Peter Greer. (2002) Closing in on the biological functions of fps/fes and fer. Nature Reviews Molecular Cell Biology 3:4, pages 278-289.
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Thomas E. Smithgall. 2002. Wiley Encyclopedia of Molecular Medicine. Wiley Encyclopedia of Molecular Medicine.
Paul T Jubinsky, Angela Messer, Jeremy Bender, Randal E Morris, Georgianne M Ciraolo, David P Witte, Robert G Hawley & Mary K Short. (2001) Identification and characterization of Magmas, a novel mitochondria-associated protein involved in granulocyte-macrophage colony-stimulating factor signal transduction. Experimental Hematology 29:12, pages 1392-1402.
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Tsukasa Oda, Masa-aki Muramatsu, Takao Isogai, Yasuhiko Masuho, Shigetaka Asano & Takayuki Yamashita. (2001) HSH2: A Novel SH2 Domain-Containing Adapter Protein Involved in Tyrosine Kinase Signaling in Hematopoietic Cells. Biochemical and Biophysical Research Communications 288:5, pages 1078-1086.
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Peter Keller, Jennifer L. Payne, Gabi Tremml, Peter A. Greer, Mirella Gaboli, Pier P. Pandolfi & Monica Bessler. (2001) Fes-Cre Targets Phosphatidylinositol Glycan Class a (Piga) Inactivation to Hematopoietic Stem Cells in the Bone Marrow. Journal of Experimental Medicine 194:5, pages 581-590.
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Ralph Zirngibl, Derek Schulze, Shelagh E.L. Mirski, Susan P.C. Cole & Peter A. Greer. (2001) Subcellular Localization Analysis of the Closely Related Fps/Fes and Fer Protein-Tyrosine Kinases Suggests a Distinct Role for Fps/Fes in Vesicular Trafficking. Experimental Cell Research 266:1, pages 87-94.
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Ahlke HeydemannSoren WarmingCynthia ClendeninKirsten SigristJ. Peter HjorthM. Celeste Simon. (2000) A minimal c-fes cassette directs myeloid-specific expression in transgenic mice. Blood 96:9, pages 3040-3048.
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Ahlke HeydemannSoren WarmingCynthia ClendeninKirsten SigristJ. Peter HjorthM. Celeste Simon. (2000) A minimal c-fes cassette directs myeloid-specific expression in transgenic mice. Blood 96:9, pages 3040-3048.
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Christophe Cans, Raffaella Mangano, Daniela Barilá, Gitte Neubauer & Giulio Superti-Furga. (2000) Nuclear tyrosine phosphorylation: the beginning of a map. Biochemical Pharmacology 60:8, pages 1203-1215.
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Renee Hackenmiller, Jynho Kim, Ricardo A. Feldman & M.Celeste Simon. (2000) Abnormal Stat Activation, Hematopoietic Homeostasis, and Innate Immunity in c-fes−/− Mice. Immunity 13:3, pages 397-407.
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Thomas E Smithgall, Scott D Briggs, Steven Schreiner, Edwina C Lerner, Haiyun Cheng & Matthew B Wilson. (2000) Control of myeloid differentiation and survival by Stats. Oncogene 19:21, pages 2612-2618.
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