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Transcriptional Regulation

The Rpb4 Subunit of Fission Yeast Schizosaccharomyces pombe RNA Polymerase II Is Essential for Cell Viability and Similar in Structure to the Corresponding Subunits of Higher Eukaryotes

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Pages 7511-7518 | Received 26 Jul 1999, Accepted 16 Aug 1999, Published online: 28 Mar 2023

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Read on this site (7)

Zachary C. Poss, Christopher C. Ebmeier & Dylan J. Taatjes. (2013) The Mediator complex and transcription regulation. Critical Reviews in Biochemistry and Molecular Biology 48:6, pages 575-608.
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Nimisha Sharma & Rashmi Kumari. (2013) Rpb4 and Rpb7: multifunctional subunits of RNA polymerase II. Critical Reviews in Microbiology 39:4, pages 362-372.
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Tibor Pankotai, Orbán Komonyi, László Bodai, Zsuzsanna Újfaludi, Selen Muratoglu, Anita Ciurciu, László Tora, János Szabad & Imre Boros. (2005) The Homologous Drosophila Transcriptional Adaptors ADA2a and ADA2b Are both Required for Normal Development but Have Different Functions. Molecular and Cellular Biology 25:18, pages 8215-8227.
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Magali Siaut, Cécile Zaros, Emilie Levivier, Maria-Laura Ferri, Magali Court, Michel Werner, Isabelle Callebaut, Pierre Thuriaux, André Sentenac & Christine Conesa. (2003) An Rpb4/Rpb7-Like Complex in Yeast RNA Polymerase III Contains the Orthologue of Mammalian CGRP-RCP. Molecular and Cellular Biology 23:1, pages 195-205.
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Qian Tan, Xin Li, Parag P. Sadhale, Takenori Miyao & Nancy A. Woychik. (2000) Multiple Mechanisms of Suppression Circumvent Transcription Defects in an RNA Polymerase Mutant. Molecular and Cellular Biology 20:21, pages 8124-8133.
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Akira Ishiguro, Yasuhisa Nogi, Koji Hisatake, Masami Muramatsu & Akira Ishihama. (2000) The Rpb6 Subunit of Fission Yeast RNA Polymerase II Is a Contact Target of the Transcription Elongation Factor TFIIS. Molecular and Cellular Biology 20:4, pages 1263-1270.
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Articles from other publishers (36)

A.I. Garrido-Godino, M. Martín-Expósito, F. Gutiérrez-Santiago, J. Perez-Fernandez & F. Navarro. (2022) Rpb4/7, a key element of RNA pol II to coordinate mRNA synthesis in the nucleus with cytoplasmic functions in Saccharomyces cerevisiae. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1865:5, pages 194846.
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José Carlos Montañés, Marta Huertas, Simone G. Moro, William R. Blevins, Mercè Carmona, José Ayté, Elena Hidalgo & M. Mar Albà. (2022) Native RNA sequencing in fission yeast reveals frequent alternative splicing isoforms. Genome Research 32:6, pages 1215-1227.
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Milind Jagota, Raphael J.L. Townshend, Lin-Woo Kang, David A. Bushnell, Ron O. Dror, Roger D. Kornberg & Maia Azubel. (2021) Gold nanoparticles and tilt pairs to assess protein flexibility by cryo-electron microscopy. Ultramicroscopy 227, pages 113302.
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Masanari Maeta, Miku Kataoka, Yusuke Nishiya, Kazutoyo Ogino, Makoto Kashima & Hiromi Hirata. (2020) RNA polymerase II subunit D is essential for zebrafish development. Scientific Reports 10:1.
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Deepak Kumar, Swati Varshney, Shantanu Sengupta & Nimisha Sharma. (2019) A comparative study of the proteome regulated by the Rpb4 and Rpb7 subunits of RNA polymerase II in fission yeast. Journal of Proteomics 199, pages 77-88.
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Deepak Kumar & Nimisha Sharma. (2018) Genome-wide transcriptional response to altered levels of the Rpb7 subunit of RNA polymerase II identifies its role in DNA damage response in Schizosaccharomyces pombe . FEMS Yeast Research 19:1.
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Miguel Garavís, Noelia González-Polo, Paula Allepuz-Fuster, Jaime Alegrio Louro, Carlos Fernández-Tornero & Olga Calvo. (2017) Sub1 contacts the RNA polymerase II stalk to modulate mRNA synthesis. Nucleic Acids Research 45:5, pages 2458-2471.
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Deepak Kumar & Nimisha Sharma. (2015) Modulating the level of the Rpb7 subunit of RNA polymerase II affects cell separation in Schizosaccharomyces pombe. Research in Microbiology 166:1, pages 20-27.
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Gang Cai, Tsuyoshi Imasaki, Kentaro Yamada, Francesco Cardelli, Yuichiro Takagi & Francisco J Asturias. (2010) Mediator Head module structure and functional interactions. Nature Structural & Molecular Biology 17:3, pages 273-279.
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Tibor Pankotai, Zsuzsanna Újfaludi, Edith Vámos, Katalin Suri & Imre Miklos Boros. (2009) The dissociable RPB4 subunit of RNA Pol II has vital functions in Drosophila. Molecular Genetics and Genomics 283:1.
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Roumiana Todorova. (2008) In vitro interaction between the N-terminus of the Ewing’s sarcoma protein and the subunit of RNA polymerase II hsRPB7. Molecular Biology Reports 36:6, pages 1269-1274.
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Nimisha Sharma & Surbhi Mehta. 2009. Yeast Biotechnology: Diversity and Applications. Yeast Biotechnology: Diversity and Applications 405 432 .
Anna J. Jasiak, Holger Hartmann, Elena Karakasili, Marian Kalocsay, Andrew Flatley, Elisabeth Kremmer, Katja Strässer, Dietmar E. Martin, Johannes Söding & Patrick Cramer. (2008) Genome-associated RNA Polymerase II Includes the Dissociable Rpb4/7 Subcomplex. Journal of Biological Chemistry 283:39, pages 26423-26427.
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Shabaz Mohammed, Kristina Lorenzen, Robert Kerkhoven, Bas van Breukelen, Alessandro Vannini, Patrick Cramer & Albert J. R. Heck. (2008) Multiplexed Proteomics Mapping of Yeast RNA Polymerase II and III Allows Near-Complete Sequence Coverage and Reveals Several Novel Phosphorylation Sites. Analytical Chemistry 80:10, pages 3584-3592.
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Sunanda R. Singh, Beena Pillai, Bindu Balakrishnan, Aruna Naorem & Parag P. Sadhale. (2007) Relative levels of RNA polII subunits differentially affect starvation response in budding yeast. Biochemical and Biophysical Research Communications 356:1, pages 266-272.
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Parag Sadhale, Jiyoti Verma & Aruna Naorem. (2007) Basal transcription machinery: role in regulation of stress response in eukaryotes. Journal of Biosciences 32:3, pages 569-578.
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Nimisha Sharma, Samuel Marguerat, Surbhi Mehta, Stephen Watt & Jürg Bähler. (2006) The fission yeast Rpb4 subunit of RNA polymerase II plays a specialized role in cell separation. Molecular Genetics and Genomics 276:6, pages 545-554.
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Anna J. Jasiak, Karim-Jean Armache, Birgit Martens, Ralf-Peter Jansen & Patrick Cramer. (2006) Structural Biology of RNA Polymerase III: Subcomplex C17/25 X-Ray Structure and 11 Subunit Enzyme Model. Molecular Cell 23:1, pages 71-81.
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Man-Hee Suh, Ping Ye, Mincheng Zhang, Stéphane Hausmann, Stewart Shuman, Averell L. Gnatt & Jianhua Fu. (2005) Fcp1 directly recognizes the C-terminal domain (CTD) and interacts with a site on RNA polymerase II distinct from the CTD. Proceedings of the National Academy of Sciences 102:48, pages 17314-17319.
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Archana Sareen, Priya Choudhry, Surbhi Mehta & Nimisha Sharma. (2005) Mapping the interaction site of Rpb4 and Rpb7 subunits of RNA polymerase II in Saccharomyces cerevisiae. Biochemical and Biophysical Research Communications 332:3, pages 763-770.
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Yukiko Imazawa, Koji Hisatake, Hiroshi Mitsuzawa, Masahito Matsumoto, Tohru Tsukui, Kaori Nakagawa, Tomoyoshi Nakadai, Miho Shimada, Akira Ishihama & Yasuhisa Nogi. (2005) The Fission Yeast Protein Ker1p Is an Ortholog of RNA Polymerase I Subunit A14 in Saccharomyces cerevisiae and Is Required for Stable Association of Rrn3p and RPA21 in RNA Polymerase I. Journal of Biological Chemistry 280:12, pages 11467-11474.
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Vinaya Sampath & Parag Sadhale. (2005) Rpb4 and Rpb7: A Sub-complex Integral to Multi-subunit RNA Polymerases Performs a Multitude of Functions. IUBMB Life (International Union of Biochemistry and Molecular Biology: Life) 57:2, pages 93-102.
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Hiroshi Mitsuzawa, Makoto Kimura, Emi Kanda & Akira Ishihama. (2005) Glyceraldehyde-3-phosphate dehydrogenase and actin associate with RNA polymerase II and interact with its Rpb7 subunit. FEBS Letters 579:1, pages 48-52.
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Patrick Cramer. 2004. Proteins in Eukaryotic Transcription. Proteins in Eukaryotic Transcription 1 42 .
Makoto Kimura, Hiroshi Mitsuzawa & Akira Ishihama. 2004. The Molecular Biology of Schizosaccharomyces pombe. The Molecular Biology of Schizosaccharomyces pombe 329 342 .
Henrik Spåhr, Olga Khorosjutina, Vera Baraznenok, Tomas Linder, Camilla O. Samuelsen, Damien Hermand, Tomi P. Mäkelä, Steen Holmberg & Claes M. Gustafsson. (2003) Mediator Influences Schizosaccharomyces pombe RNA Polymerase II-dependent Transcription in Vitro. Journal of Biological Chemistry 278:51, pages 51301-51306.
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Vinaya Sampath, Nambudiry Rekha, N. Srinivasan & Parag Sadhale. (2003) The Conserved and Non-conserved Regions of Rpb4 Are Involved in Multiple Phenotypes in Saccharomyces cerevisiae. Journal of Biological Chemistry 278:51, pages 51566-51576.
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Vishwas Seshadri, Andrew G. McArthur, Mitchell L. Sogin & Rodney D. Adam. (2003) Giardia lamblia RNA Polymerase II. Journal of Biological Chemistry 278:30, pages 27804-27810.
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Karim-Jean Armache, Hubert Kettenberger & Patrick Cramer. (2003) Architecture of initiation-competent 12-subunit RNA polymerase II. Proceedings of the National Academy of Sciences 100:12, pages 6964-6968.
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Kaori Nakagawa, Koji Hisatake, Yukiko Imazawa, Akira Ishiguro, Masahito Matsumoto, Louise Pape, Akira Ishihama & Yasuhisa Nogi. (2003) The fission yeast RPA51 is a functional homolog of the budding yeast A49 subunit of RNA polymerase I and required for maximizing transcription of ribosomal DNA. Genes & Genetic Systems 78:3, pages 199-209.
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Hitomi Sakurai & Akira Ishihama. (2002) Level of the RNA polymerase II in the fission yeast stays constant but phosphorylation of its carboxyl terminal domain varies depending on the phase and rate of cell growth. Genes to Cells 7:3, pages 273-284.
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Huiqing Zhou & Kevin AW Lee. (2001) An hsRPB4/7-dependent yeast assay for trans-activation by the EWS oncogene. Oncogene 20:12, pages 1519-1524.
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Makoto Kimura, Hitomi Sakurai & Akira Ishihama. (2001) Intracellular contents and assembly states of all 12 subunits of the RNA polymerase II in the fission yeast Schizosaccharomyces pombe . European Journal of Biochemistry 268:3, pages 612-619.
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Hitomi Sakurai & Akira Ishihama. (2001) Transcription organization and mRNA levels of the genes for all 12 subunits of the fission yeast RNA polymerase II. Genes to Cells 6:1, pages 25-36.
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G. V. Shpakovski & G. M. Baranova. (2000) Chromosomal localization of therpb9 + andtfa1 + genes encoding components of the mRNA synthesis machinery ofSchizosaccharomyces pombe. Russian Journal of Bioorganic Chemistry 26:9, pages 559-565.
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George V Shpakovski, Olivier Gadal, Sylvie Labarre-Mariotte, Ekaterina N Lebedenko, Ida Miklos, Hitomi Sakurai, Sergey A Proshkin, Vincent Van Mullem, Akira Ishihama & Pierre Thuriaux. (2000) Functional conservation of RNA polymerase II in fission and budding yeasts. Journal of Molecular Biology 295:5, pages 1119-1127.
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