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Cell Growth and Development

Requirement for Ras/Rac1-Mediated p38 and c-Jun N-Terminal Kinase Signaling in Stat3 Transcriptional Activity Induced by the Src Oncoprotein

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Pages 7519-7528 | Received 19 Feb 1999, Accepted 05 Aug 1999, Published online: 28 Mar 2023

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Rozanne Arulanandam, Cory Batenchuk, Fernando A. Angarita, Kathryn Ottolino-Perry, Sophie Cousineau, Amelia Mottashed, Emma Burgess, Theresa J. Falls, Naomi De Silva, Jovian Tsang, Grant A. Howe, Marie-Claude Bourgeois-Daigneault, David P. Conrad, Manijeh Daneshmand, Caroline J. Breitbach, David H. Kirn, Leda Raptis, Subash Sad, Harold Atkins, Michael S. Huh, Jean-Simon Diallo, Brian D. Lichty, Carolina S. Ilkow, Fabrice Le Boeuf, Christina L. Addison, J. Andrea McCart & John C. Bell. (2015) VEGF-Mediated Induction of PRD1-BF1/Blimp1 Expression Sensitizes Tumor Vasculature to Oncolytic Virus Infection. Cancer Cell 28:2, pages 210-224.
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Mark E. Ebel, Olufolakemi Awe, Mark H. Kaplan & Geoffrey S. Kansas. (2015) Diverse Inflammatory Cytokines Induce Selectin Ligand Expression on Murine CD4 T Cells via p38α MAPK. The Journal of Immunology 194:12, pages 5781-5788.
Crossref
Yesol Bak, Jeong-Woo Kang, Man Sub Kim, Yun Sun Park, Taeho Kwon, Soohyun Kim, Jintae Hong & Do-Young Yoon. (2014) IL-32θ downregulates CCL5 expression through its interaction with PKCδ and STAT3. Cellular Signalling 26:12, pages 3007-3015.
Crossref
Ki-Seok Choi, Joydeb Kumar Kundu, Kyung-Soo Chun, Hye-Kyung Na & Young-Joon Surh. (2014) Rutin inhibits UVB radiation-induced expression of COX-2 and iNOS in hairless mouse skin: p38 MAP kinase and JNK as potential targets. Archives of Biochemistry and Biophysics 559, pages 38-45.
Crossref
Kazuhiro Yamamoto, Atsushi Mizumoto, Kohji Nishimura, Atsushi Uda, Akira Mukai, Kazuhiko Yamashita, Manabu Kume, Hiroo Makimoto, Toshinori Bito, Chikako Nishigori, Tsutomu Nakagawa, Takeshi Hirano & Midori Hirai. (2014) Association of Toxicity of Sorafenib and Sunitinib for Human Keratinocytes with Inhibition of Signal Transduction and Activator of Transcription 3 (STAT3). PLoS ONE 9:7, pages e102110.
Crossref
Lanxi Song, Matthew A. Smith, Parul Doshi, Kate Sasser, William Fulp, Soner Altiok & Eric B. Haura. (2014) Antitumor Efficacy of the Anti-Interleukin-6 (IL-6) Antibody Siltuximab in Mouse Xenograft Models of Lung Cancer. Journal of Thoracic Oncology 9:7, pages 974-982.
Crossref
Ira J. Smith, Guillermo L. Godinez, Baljit K. Singh, Kelly M. McCaughey, Raniel R. Alcantara, Tarikere Gururaja, Melissa S. Ho, Henry N. Nguyen, Annabelle M. Friera, Kathy A. White, John R. McLaughlin, Derek Hansen, Jason M. Romero, Kristen A. Baltgalvis, Mark D. Claypool, Wei Li, Wayne Lang, George C. Yam, Marina S. Gelman, Rongxian Ding, Stephanie L. Yung, Daniel P. Creger, Yan Chen, Rajinder Singh, Ashley J. Smuder, Michael P. Wiggs, Oh‐Sung Kwon, Kurt J. Sollanek, Scott K. Powers, Esteban S. Masuda, Vanessa C. Taylor, Donald G. Payan, Taisei Kinoshita & Todd M. Kinsella. (2014) Inhibition of Janus kinase signaling during controlled mechanical ventilation prevents ventilation‐induced diaphragm dysfunction. The FASEB Journal 28:7, pages 2790-2803.
Crossref
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Crossref
Jennifer Bishop, Daksh Thaper & Amina Zoubeidi. (2014) The Multifaceted Roles of STAT3 Signaling in the Progression of Prostate Cancer. Cancers 6:2, pages 829-859.
Crossref
Bingliang Fang. (2014) Genetic Interactions of STAT3 and Anticancer Drug Development. Cancers 6:1, pages 494-525.
Crossref
Lisette P. YcoGabor MoczJohn Opoku-AnsahAndré S. Bachmann. (2014) Withaferin A Inhibits STAT3 and Induces Tumor Cell Death in Neuroblastoma and Multiple Myeloma. Biochemistry Insights 7, pages BCI.S18863.
Crossref
Kazuhiro Yamamoto, Atsushi Uda, Akira Mukai, Kazuhiko Yamashita, Manabu Kume, Hiroo Makimoto, Toshinori Bito, Chikako Nishigori, Takeshi Hirano & Midori Hirai. (2013) Everolimus-induced human keratinocytes toxicity is mediated by STAT3 inhibition. Journal of Experimental & Clinical Cancer Research 32:1.
Crossref
Youn Hee Park, Young Mi Lee, Dong Sun Kim, Jaechan Park, Kyoungho Suk, Jong Kun Kim & Hyung Soo Han. (2013) Hypothermia enhances induction of protective protein metallothionein under ischemia. Journal of Neuroinflammation 10:1.
Crossref
Christine A. King. (2013) Kaposi's Sarcoma-Associated Herpesvirus Kaposin B Induces Unique Monophosphorylation of STAT3 at Serine 727 and MK2-Mediated Inactivation of the STAT3 Transcriptional Repressor TRIM28. Journal of Virology 87:15, pages 8779-8791.
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Tasnim Ara, Rie Nakata, Michael A. Sheard, Hiroyuki Shimada, Ralf Buettner, Susan G. Groshen, Lingyun Ji, Hua Yu, Richard Jove, Robert C. Seeger & Yves A. DeClerck. (2013) Critical Role of STAT3 in IL-6–Mediated Drug Resistance in Human Neuroblastoma. Cancer Research 73:13, pages 3852-3864.
Crossref
K. Martínez Flores, B.C. Uribe Marín, V. Souza Arroyo, L. Bucio Ortiz, A. López Reyes, L.E. Gómez-Quiroz, E. Rojas del Castillo & M.C. Gutiérrez Ruiz. (2013) Hepatocytes display a compensatory survival response against cadmium toxicity by a mechanism mediated by EGFR and Src. Toxicology in Vitro 27:3, pages 1031-1042.
Crossref
Mohammad Zahid Kamran, Prachi Patil & Rajiv P. Gude. (2013) Role of STAT3 in Cancer Metastasis and Translational Advances. BioMed Research International 2013, pages 1-15.
Crossref
Karolina Swiatek-Machado & Bozena Kaminska. 2013. Glioma Signaling. Glioma Signaling 189 208 .
Erik A. Nelson, Sarah R. Walker & David A. Frank. 2013. Advances in Biology and Therapy of Multiple Myeloma. Advances in Biology and Therapy of Multiple Myeloma 117 138 .
Youxing Li, Qi Zhang, Yin Liu, Zhen Luo, Lei Kang, Jing Qu, Weiyong Liu, Xueshan Xia, Yingle Liu, Kailang Wu & Jianguo Wu. (2012) Hepatitis C Virus Activates Bcl-2 and MMP-2 Expression through Multiple Cellular Signaling Pathways. Journal of Virology 86:23, pages 12531-12543.
Crossref
J. Liu, B. Chen, Y. Lu, Y. Guan & F. Chen. (2012) JNK-Dependent Stat3 Phosphorylation Contributes to Akt Activation in Response to Arsenic Exposure. Toxicological Sciences 129:2, pages 363-371.
Crossref
Jinghua Han, Fei Zhang, Man Yu, Peiqi Zhao, Wei Ji, Haichang Zhang, Bing Wu, Yuqing Wang & Ruifang Niu. (2012) RNA interference-mediated silencing of NANOG reduces cell proliferation and induces G0/G1 cell cycle arrest in breast cancer cells. Cancer Letters 321:1, pages 80-88.
Crossref
Elad KatzAndrew H. SimsDuncan Sproul, Helen CaldwellJ. Michael DixonRichard R. Meehan & David J. Harrison. (2012) Targeting of Rac GTPases blocks the spread of intact human breast cancer. Oncotarget 3:6, pages 608-619.
Crossref
Xiaolei ZhangPeibin YueBrent D. G. Page, Tianshu LiWei ZhaoAndrew T. Namanja, David PaladinoJihe ZhaoYuan Chen, Patrick T. Gunning & James Turkson. (2012) Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts. Proceedings of the National Academy of Sciences 109:24, pages 9623-9628.
Crossref
Simone Reipschläger, Katharina Kubatzky, Sanaz Taromi, Meike Burger, Joachim Orth, Klaus Aktories & Gudula Schmidt. (2012) Toxin-induced RhoA Activity Mediates CCL1-triggered Signal Transducers and Activators of Transcription Protein Signaling. Journal of Biological Chemistry 287:14, pages 11183-11194.
Crossref
Yu Zhang. (2012) A novel bayesian graphical model for genome-wide multi-SNP association mapping. Genetic Epidemiology 36:1, pages 36-47.
Crossref
Leda Raptis, Rozanne Arulanandam, Mulu Geletu & James Turkson. (2011) The R(h)oads to Stat3: Stat3 activation by the Rho GTPases. Experimental Cell Research 317:13, pages 1787-1795.
Crossref
Lanxi Song, Bhupendra Rawal, Jeffrey A. Nemeth & Eric B. Haura. (2011) JAK1 Activates STAT3 Activity in Non-Small–Cell Lung Cancer Cells and IL-6 Neutralizing Antibodies Can Suppress JAK1-STAT3 Signaling. Molecular Cancer Therapeutics 10:3, pages 481-494.
Crossref
Wei Zhao, Soumya Jaganathan & James Turkson. (2010) A Cell-permeable Stat3 SH2 Domain Mimetic Inhibits Stat3 Activation and Induces Antitumor Cell Effects in Vitro. Journal of Biological Chemistry 285:46, pages 35855-35865.
Crossref
Xiaolei Zhang, Peibin Yue, Steven Fletcher, Wei Zhao, Patrick T. Gunning & James Turkson. (2010) A novel small-molecule disrupts Stat3 SH2 domain–phosphotyrosine interactions and Stat3-dependent tumor processes. Biochemical Pharmacology 79:10, pages 1398-1409.
Crossref
E. Wallerstedt, U. Smith & C. X. Andersson. (2010) Protein kinase C-δ is involved in the inflammatory effect of IL-6 in mouse adipose cells. Diabetologia 53:5, pages 946-954.
Crossref
Melissa Muller & Prahlad T. Ram. 2010. Systems Biology for Signaling Networks. Systems Biology for Signaling Networks 455 489 .
S. Yubero, L. Ramudo, M.A. Manso & I. De Dios. (2009) Mechanisms of dexamethasone-mediated chemokine down-regulation in mild and severe acute pancreatitis. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1792:12, pages 1205-1211.
Crossref
O J Broom, B Widjaya, J Troelsen, J Olsen & O H Nielsen. (2009) Mitogen activated protein kinases: a role in inflammatory bowel disease?. Clinical and Experimental Immunology 158:3, pages 272-280.
Crossref
Noriko Doki, Toshiyuki Kawashima, Yasushi Nomura, Akiho Tsuchiya, Chitose Oneyama, Tsuyoshi Akagi, Yoshihisa Nojima & Toshio Kitamura. (2009) Constitutive phosphorylation of a Rac GAP MgcRacGAP is implicated in v-Src-induced transformation of NIH3T3 cells. Cancer Science 100:9, pages 1675-1679.
Crossref
Kelly M Kroeger, Brandon M Sullivan & Richard M Locksley. (2009) IL-18 and IL-33 elicit Th2 cytokines from basophils via a MyD88- and p38α-dependent pathway. Journal of Leukocyte Biology 86:4, pages 769-778.
Crossref
Raina Devi Ramnath, Jia Sun & Madhav Bhatia. (2009) Involvement of Src Family Kinases in Substance P-Induced Chemokine Production in Mouse Pancreatic Acinar Cells and Its Significance in Acute Pancreatitis. Journal of Pharmacology and Experimental Therapeutics 329:2, pages 418-428.
Crossref
Sabrina Garcia de Aquino, Fabio Renato Manzolli Leite, Dagmar Ruth Stach-Machado, Juliete Aparecida Francisco da Silva, Luís Carlos Spolidorio & Carlos RossaJr.Jr.. (2009) Signaling pathways associated with the expression of inflammatory mediators activated during the course of two models of experimental periodontitis. Life Sciences 84:21-22, pages 745-754.
Crossref
Hsuan-Heng YehRaghavaraju GiriTsuey-Yu ChangCheng-Yang ChouWu-Chou SuHsiao-Sheng Liu. (2009) Ha- ras Oncogene–Induced Stat3 Phosphorylation Enhances Oncogenicity of the Cell . DNA and Cell Biology 28:3, pages 131-139.
Crossref
Hye-Jin ChoiJung Han LeeShin-Young ParkJu Hwan ChoJoong-Soo Han. (2009) STAT3 is involved in phosphatidic acid-induced Bcl-2 expression in HeLa cells. Experimental and Molecular Medicine 41:2, pages 94.
Crossref
Marcello Guarino. (2009) Src signaling in cancer invasion. Journal of Cellular Physiology, pages n/a-n/a.
Crossref
Min-Jung Kim, Joo-Yun Byun, Chang-Hwan Yun, In-Chul Park, Kee-Ho Lee & Su-Jae Lee. (2008) c-Src-p38 Mitogen-Activated Protein Kinase Signaling Is Required for Akt Activation in Response to Ionizing Radiation. Molecular Cancer Research 6:12, pages 1872-1880.
Crossref
S Sobue, M Murakami, Y Banno, H Ito, A Kimura, S Gao, A Furuhata, A Takagi, T Kojima, M Suzuki, Y Nozawa & T Murate. (2008) v-Src oncogene product increases sphingosine kinase 1 expression through mRNA stabilization: alteration of AU-rich element-binding proteins. Oncogene 27:46, pages 6023-6033.
Crossref
Giannis Mountzios, Pierre Fouret & Jean-Charles Soria. (2008) Mechanisms of Disease: signal transduction in lung carcinogenesis—a comparison of smokers and never-smokers. Nature Clinical Practice Oncology 5:10, pages 610-618.
Crossref
Toshiaki Miyazaki, Jeffrey D. Bub & Yoshiki Iwamoto. (2008) c-Jun NH2-terminal kinase mediates leptin-stimulated androgen-independent prostate cancer cell proliferation via signal transducer and activator of transcription 3 and Akt. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1782:10, pages 593-604.
Crossref
Chang Han, William C. Bowen, George K. Michalopoulos & Tong Wu. (2008) Alpha-1 adrenergic receptor transactivates signal transducer and activator of transcription-3 (Stat3) through activation of Src and epidermal growth factor receptor (EGFR) in hepatocytes. Journal of Cellular Physiology 216:2, pages 486-497.
Crossref
Roxana Pincheira, Ariel F. Castro, Osman Nidai Ozes, Prema S. Idumalla & David B. Donner. (2008) Type 1 TNF Receptor Forms a Complex with and Uses Jak2 and c-Src to Selectively Engage Signaling Pathways That Regulate Transcription Factor Activity. The Journal of Immunology 181:2, pages 1288-1298.
Crossref
Hui Zhang, Wei Feng, Wenqiang Liao, Xiaowei Ma, Qide Han & Youyi Zhang. (2008) The gp130/STAT3 signaling pathway mediates β-adrenergic receptor-induced atrial natriuretic factor expression in cardiomyocytes. FEBS Journal 275:14, pages 3590-3597.
Crossref
Lilly Y.W. Bourguignon, Karine Peyrollier, Weiliang Xia & Eli Gilad. (2008) Hyaluronan-CD44 Interaction Activates Stem Cell Marker Nanog, Stat-3-mediated MDR1 Gene Expression, and Ankyrin-regulated Multidrug Efflux in Breast and Ovarian Tumor Cells. Journal of Biological Chemistry 283:25, pages 17635-17651.
Crossref
Stanislaw M. Stepkowski, Wenhao Chen, Jeremy A. Ross, Zsuzsanna S. Nagy & Robert A. Kirken. (2008) STAT3: An Important Regulator of Multiple Cytokine Functions. Transplantation 85:10, pages 1372-1377.
Crossref
Khandaker Al Zaid Siddiquee & James Turkson. (2008) STAT3 as a target for inducing apoptosis in solid and hematological tumors. Cell Research 18:2, pages 254-267.
Crossref
Khandaker A. Z. Siddiquee, Patrick T. Gunning, Matthew Glenn, William P. Katt, Shumin Zhang, Christopher Schroeck, Said M. Sebti, Richard Jove, Andrew D. Hamilton & James Turkson. (2007) An Oxazole-Based Small-Molecule Stat3 Inhibitor Modulates Stat3 Stability and Processing and Induces Antitumor Cell Effects. ACS Chemical Biology 2:12, pages 787-798.
Crossref
A Sirvent, A Boureux, V Simon, C Leroy & S Roche. (2007) The tyrosine kinase Abl is required for Src-transforming activity in mouse fibroblasts and human breast cancer cells. Oncogene 26:52, pages 7313-7323.
Crossref
Junko Nakagawa, Gen Nishitai, Kiyoshi Inageda & Masato Matsuoka. (2007) Phosphorylation of Stats at Ser727 in renal proximal tubular epithelial cells exposed to cadmium. Environmental Toxicology and Pharmacology 24:3, pages 252-259.
Crossref
Smita Zaheer, Yanghong Wu, Jon Bassett, Baoli Yang & Asgar Zaheer. (2007) Glia Maturation Factor Regulation of STAT Expression: A Novel Mechanism in Experimental Autoimmune Encephalomyelitis. Neurochemical Research 32:12, pages 2123-2131.
Crossref
Frederick W. Quelle. (2007) Cytokine signaling to the cell cycle. Immunologic Research 39:1-3, pages 173-184.
Crossref
Christian X. Andersson, Victoria Rotter Sopasakis, Emelie Wallerstedt & Ulf Smith. (2007) Insulin Antagonizes Interleukin-6 Signaling and Is Anti-inflammatory in 3T3-L1 Adipocytes. Journal of Biological Chemistry 282:13, pages 9430-9435.
Crossref
C. Petterino, G. Podestà, A. Ratto, M. Drigo & C. Pellegrino. (2006) Immunohistochemical Study of Phospho-Stat3-ser727 Expression in Feline Mammary Gland Tumours. Veterinary Research Communications 31:2, pages 173-184.
Crossref
Kazutaka Horie, Makoto Ohashi, Yukio Satoh & Takeshi Sairenji. (2007) The Role of p38 Mitogen-Activated Protein Kinase in Regulating Interleukin-10 Gene Expression in Burkitt's Lymphoma Cell Lines. Microbiology and Immunology 51:1, pages 149-161.
Crossref
BHARAT B. AGGARWAL, GAUTAM SETHI, KWANG SEOK AHN, SANTOSH K. SANDUR, MANOJ K. PANDEY, AJAIKUMAR B. KUNNUMAKKARA, BOKYUNG SUNG & HARUYO ICHIKAWA. (2006) Targeting Signal-Transducer-and-Activator-of-Transcription-3 for Prevention and Therapy of Cancer. Annals of the New York Academy of Sciences 1091:1, pages 151-169.
Crossref
Andrew M.F. Liu, Rico K.H. Lo, Cecilia S.S. Wong, Christina Morris, Helen Wise & Yung H. Wong. (2006) Activation of STAT3 by Gαs Distinctively Requires Protein Kinase A, JNK, and Phosphatidylinositol 3-Kinase. Journal of Biological Chemistry 281:47, pages 35812-35825.
Crossref
Sreenath V. Sharma, Patrycja Gajowniczek, Inna P. Way, Diana Y. Lee, Jane Jiang, Yuki Yuza, Marie Classon, Daniel A. Haber & Jeffrey Settleman. (2006) A common signaling cascade may underlie “addiction” to the Src, BCR-ABL, and EGF receptor oncogenes. Cancer Cell 10:5, pages 425-435.
Crossref
Zsuzsanna S. Nagy, Hallgeir Rui, Stanislaw M. Stepkowski, James Karras & Robert A. Kirken. (2006) A Preferential Role for STAT5, not Constitutively Active STAT3, in Promoting Survival of a Human Lymphoid Tumor. The Journal of Immunology 177:8, pages 5032-5040.
Crossref
K.B. Washburn & J.T. Neary. (2006) P2 purinergic receptors signal to STAT3 in astrocytes: Difference in STAT3 responses to P2Y and P2X receptor activation. Neuroscience 142:2, pages 411-423.
Crossref
Stanislaw M. Stepkowski & Robert A. Kirken. (2006) Janus Tyrosine Kinases and Signal Transducers and Activators of Transcription Regulate Critical Functions of T Cells in Allograft Rejection and Transplantation Tolerance. Transplantation 82:3, pages 295-303.
Crossref
Chang Han, A. Jake Demetris, Donna B. Stolz, Lihong Xu, Kyu Lim & Tong Wu. (2006) Modulation of Stat3 Activation by the Cytosolic Phospholipase A2α and Cyclooxygenase-2-controlled Prostaglandin E2 Signaling Pathway. Journal of Biological Chemistry 281:34, pages 24831-24846.
Crossref
Mark A. Gerber, Scott M. Bahr & David H. Gutmann. (2006) Protein 4.1B/Differentially Expressed in Adenocarcinoma of the Lung-1 Functions as a Growth Suppressor in Meningioma Cells by Activating Rac1-Dependent c-Jun-NH2-kinase Signaling. Cancer Research 66:10, pages 5295-5303.
Crossref
E J Wojcik, S Sharifpoor, N A Miller, T G Wright, R Watering, E A Tremblay, K Swan, C R Mueller & B E Elliott. (2006) A novel activating function of c-Src and Stat3 on HGF transcription in mammary carcinoma cells. Oncogene 25:19, pages 2773-2784.
Crossref
S Ito, Y Ito, T Senga, S Hattori, S Matsuo & M Hamaguchi. (2005) v-Src requires Ras signaling for the suppression of gap junctional intercellular communication. Oncogene 25:16, pages 2420-2424.
Crossref
Anupama Kotha, Madhavi Sekharam, Lucia Cilenti, Khandaker Siddiquee, Annette Khaled, Antonis S. Zervos, Bradford Carter, James Turkson & Richard Jove. (2006) Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein. Molecular Cancer Therapeutics 5:3, pages 621-629.
Crossref
Rico K.H. Lo, Helen Wise & Yung H. Wong. (2006) Prostacyclin receptor induces STAT1 and STAT3 phosphorylations in human erythroleukemia cells: A mechanism requiring PTX-insensitive G proteins, ERK and JNK. Cellular Signalling 18:3, pages 307-317.
Crossref
R N Kumar, S K Shore & N Dhanasekaran. (2005) Neoplastic transformation by the gep oncogene, Gα12, involves signaling by STAT3. Oncogene 25:6, pages 899-906.
Crossref
Marina Gartsbein, Addy Alt, Koji Hashimoto, Koichi Nakajima, Toshio Kuroki & Tamar Tennenbaum. (2006) The role of protein kinase C δ activation and STAT3 Ser727 phosphorylation in insulin-induced keratinocyte proliferation. Journal of Cell Science 119:3, pages 470-481.
Crossref
Cheh Peng Lim & Xinmin Cao. (2006) Structure, function, and regulation of STAT proteins. Molecular BioSystems 2:11, pages 536.
Crossref
James Turkson, Shumin Zhang, Linda B. Mora, Audrey Burns, Said Sebti & Richard Jove. (2005) A Novel Platinum Compound Inhibits Constitutive Stat3 Signaling and Induces Cell Cycle Arrest and Apoptosis of Malignant Cells. Journal of Biological Chemistry 280:38, pages 32979-32988.
Crossref
Anthony I. Vulin, Kirsten K. Jacob & Frederick M. Stanley. (2005) Integrin Activates Receptor-Like Protein Tyrosine Phosphatase α, Src, and Rho to Increase Prolactin Gene Expression through a Final Phosphatidylinositol 3-Kinase/Cytoskeletal Pathway that Is Additive with Insulin. Endocrinology 146:8, pages 3535-3546.
Crossref
Arata Nishimoto, Yinhua Yu, Zhen Lu, Xiang Mao, Zhiyong Ren, Stephanie S. Watowich, Gordon B. Mills, Warren S-L. Liao, Xiaomin Chen, Robert C. BastJr.Jr. & Robert Z. Luo. (2005) A Ras Homologue Member I Directly Inhibits Signal Transducers and Activators of Transcription 3 Translocation and Activity in Human Breast and Ovarian Cancer Cells. Cancer Research 65:15, pages 6701-6710.
Crossref
Bramanandam Manavathi, Sujit S. Nair, Rui-An Wang, Rakesh Kumar & Ratna K. Vadlamudi. (2005) Proline-, Glutamic Acid-, and Leucine-Rich Protein-1 Is Essential in Growth Factor Regulation of Signal Transducers and Activators of Transcription 3 Activation. Cancer Research 65:13, pages 5571-5577.
Crossref
John D. Kakisis, Sanjeev Pradhan, Alfredo Cordova, Christos D. Liapis & Bauer E. Sumpio. (2005) The role of STAT-3 in the mediation of smooth muscle cell response to cyclic strain. The International Journal of Biochemistry & Cell Biology 37:7, pages 1396-1406.
Crossref
Jiazhi Sun, Michelle A Blaskovich, Richard Jove, Sandra K Livingston, Domenico Coppola & Saïd M Sebti. (2005) Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity. Oncogene 24:20, pages 3236-3245.
Crossref
Kolaparthi Venkatasubbarao, Ahsan Choudary & James W. Freeman. (2005) Farnesyl Transferase Inhibitor (R115777)–Induced Inhibition of STAT3(Tyr705) Phosphorylation in Human Pancreatic Cancer Cell Lines Require Extracellular Signal-Regulated Kinases. Cancer Research 65:7, pages 2861-2871.
Crossref
R. Arulanandam, A. Vultur & L. Raptis. (2005) Transfection techniques affecting Stat3 activity levels. Analytical Biochemistry 338:1, pages 83-89.
Crossref
Sichuan Xi, William E Gooding & Jennifer Rubin Grandis. (2004) In vivo antitumor efficacy of STAT3 blockade using a transcription factor decoy approach: implications for cancer therapy. Oncogene 24:6, pages 970-979.
Crossref
Gulam Waris, James Turkson, Tarek Hassanein & Aleem Siddiqui. (2005) Hepatitis C Virus (HCV) Constitutively Activates STAT-3 via Oxidative Stress: Role of STAT-3 in HCV Replication. Journal of Virology 79:3, pages 1569-1580.
Crossref
Michele Caraglia, Monica Marra, Girolamo Pelaia, Rosario Maselli, Mario Caputi, Serafino A. Marsico & Alberto Abbruzzese. (2005) Alpha-interferon and its effects on signal transduction pathways. Journal of Cellular Physiology 202:2, pages 323-335.
Crossref
B. S. Wung, C. W. Ni & D. L. Wang. (2005) ICAM-1 induction by TNFα and IL-6 is mediated by distinct pathways via Rac in endothelial cells. Journal of Biomedical Science 12:1, pages 91-101.
Crossref
James Turkson, Shumin Zhang, Jay Palmer, Heidi Kay, Joseph Stanko, Linda B. Mora, Said Sebti, Hua Yu & Richard Jove. (2004) Inhibition of constitutive signal transducer and activator of transcription 3 activation by novel platinum complexes with potent antitumor activity. Molecular Cancer Therapeutics 3:12, pages 1533-1542.
Crossref
H. SiavashN.G. NikitakisJ.J. Sauk. (2016) S ignal T ransducers and A ctivators of T ranscription: I nsights into the M olecular B asis of O ral C ancer . Critical Reviews in Oral Biology & Medicine 15:5, pages 298-307.
Crossref
Li Li, Doreen Hooi, Siri Ram Chhabra, David Pritchard & Peter E Shaw. (2004) Bacterial N-acylhomoserine lactone-induced apoptosis in breast carcinoma cells correlated with down-modulation of STAT3. Oncogene 23:28, pages 4894-4902.
Crossref
Rico K. H. Lo & Yung H. Wong. (2004) Signal Transducer and Activator of Transcription 3 Activation by the δ-Opioid Receptor via Gα 14 Involves Multiple Intermediates . Molecular Pharmacology 65:6, pages 1427-1439.
Crossref
Cynthia A. Heinlein & Chawnshang Chang. (2004) Androgen Receptor in Prostate Cancer. Endocrine Reviews 25:2, pages 276-308.
Crossref
Chong-Shan Shi & John H. Kehrl. (2004) Pyk2 Amplifies Epidermal Growth Factor and c-Src-induced Stat3 Activation. Journal of Biological Chemistry 279:17, pages 17224-17231.
Crossref
Margaret C. Frame. (2004) Newest findings on the oldest oncogene; how activated src does it. Journal of Cell Science 117:7, pages 989-998.
Crossref
James Turkson, Joon S. Kim, Shumin Zhang, Jing Yuan, Mei Huang, Matthew Glenn, Eric Haura, Said Sebti, Andrew D. Hamilton & Richard Jove. (2004) Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity. Molecular Cancer Therapeutics 3:3, pages 261-269.
Crossref
Kun Jiang, Frederic L Delarue & Saïd M Sebti. (2003) EGFR, ErbB2 and Ras but not Src suppress RhoB expression while ectopic expression of RhoB antagonizes oncogene-mediated transformation. Oncogene 23:5, pages 1136-1145.
Crossref
Yasuhiro Yoshida, Arvind Kumar, Yoshinobu Koyama, Haibing Peng, Ahmet Arman, Jason A. Boch & Philip E. Auron. (2004) Interleukin 1 Activates STAT3/Nuclear Factor-κB Cross-talk via a Unique TRAF6- and p65-dependent Mechanism. Journal of Biological Chemistry 279:3, pages 1768-1776.
Crossref
Rico K.H. Lo, Helen Cheung & Yung H. Wong. (2003) Constitutively Active Gα16 Stimulates STAT3 via a c-Src/JAK- and ERK-dependent Mechanism. Journal of Biological Chemistry 278:52, pages 52154-52165.
Crossref
Qin Wang, Gordon R. PfeifferIIII & William A. Gaarde. (2003) Activation of SRC Tyrosine Kinases in Response to ICAM-1 Ligation in Pulmonary Microvascular Endothelial Cells. Journal of Biological Chemistry 278:48, pages 47731-47743.
Crossref
Christine Rivat, Nathalie Le Floch, Michèle Sabbah, Isabelle Teyrol, Gérard Redeuilh, Erik Bruyneel, Marc Mareel, Lynn M. Matrisian, Howard C. Crawford, Christian Gespach & Samir Attoub. (2003) Synergistic cooperation between the AP‐1 and LEF‐1 transcription factors in the activation of the matrilysin promoter by the src oncogene: implications in cellular invasion. The FASEB Journal 17:12, pages 1721-1723.
Crossref
Joan-Marc Servitja, Maria Julia Marinissen, Akrit Sodhi, Xosé R. Bustelo & J.Silvio Gutkind. (2003) Rac1 Function Is Required for Src-induced Transformation. Journal of Biological Chemistry 278:36, pages 34339-34346.
Crossref
Albertus T.J. Wierenga, Irma Vogelzang, Bart J.L. Eggen & Edo Vellenga. (2003) Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway. Experimental Hematology 31:5, pages 398-405.
Crossref
Mustafa BenekliMaria R. BaerHeinz BaumannMeir Wetzler. (2003) Signal transducer and activator of transcription proteins in leukemias. Blood 101:8, pages 2940-2954.
Crossref
Yiguo Zhang, Yong-Yeon Cho, Brandon L. Petersen, Ann M. Bode, Feng Zhu & Zigang Dong. (2003) Ataxia Telangiectasia Mutated Proteins, MAPKs, and RSK2 Are Involved in the Phosphorylation of STAT3. Journal of Biological Chemistry 278:15, pages 12650-12659.
Crossref
Paul L. Leong, Genevieve A. Andrews, Daniel E. Johnson, Kevin F. Dyer, Sichuan Xi, Jeffrey C. Mai, Paul D. Robbins, Seshu Gadiparthi, Nancy A. Burke, Simon F. Watkins & Jennifer Rubin Grandis. (2003) Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth. Proceedings of the National Academy of Sciences 100:7, pages 4138-4143.
Crossref
Corinne M. Silva, Julie L. Boerner & Sarah J. Parsons. 2003. Signal Transducers and Activators of Transcription (STATs). Signal Transducers and Activators of Transcription (STATs) 223 236 .
Raymond Lai, George Z Rassidakis, L Jeffrey Medeiros, Vasiliki Leventaki, Micheal Keating & Timothy J Mcdonnell. (2003) Expression of STAT3 and its phosphorylated forms in mantle cell lymphoma cell lines and tumours. The Journal of Pathology 199:1, pages 84-89.
Crossref
Sun-Young Han, Soo-Hyun Kim & Lynn E. Heasley. (2002) Differential Gene Regulation by Specific Gain-of-function JNK1 Proteins Expressed in Swiss 3T3 Fibroblasts. Journal of Biological Chemistry 277:49, pages 47167-47174.
Crossref
Hisaki Nagai, Yong Sung Kim, Noboru Konishi, Masaru Baba, Takeo Kubota, Akihiko Yoshimura & Mitsuru Emi. (2002) Combined hypermethylation and chromosome loss associated with inactivation of SSI-1/SOCS-1/JAB gene in human hepatocellular carcinomas. Cancer Letters 186:1, pages 59-65.
Crossref
Matthew B Wilson, Steven J Schreiner, Hyun-Jung Choi, Joanne Kamens & Thomas E Smithgall. (2002) Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr–Abl signal transduction and oncogenesis. Oncogene 21:53, pages 8075-8088.
Crossref
Chi Tarn, Lin Zou, Ronald L. Hullinger & Ourania M. Andrisani. (2002) Hepatitis B Virus X Protein Activates the p38 Mitogen-Activated Protein Kinase Pathway in Dedifferentiated Hepatocytes. Journal of Virology 76:19, pages 9763-9772.
Crossref
Kevin Pruitt, Wendy M. Pruitt, Graham K. Bilter, John K. Westwick & Channing J. Der. (2002) Raf-independent Deregulation of p38 and JNK Mitogen-activated Protein Kinases Are Critical for Ras Transformation. Journal of Biological Chemistry 277:35, pages 31808-31817.
Crossref
Y.J. Park, E.S. Park, M.S. Kim, T.Y. Kim, H.S. Lee, S. Lee, I.S. Jang, M. Shong, D.J. Park & Bo Youn Cho. (2002) Involvement of the protein kinase C pathway in thyrotropin-induced STAT3 activation in FRTL-5 thyroid cells. Molecular and Cellular Endocrinology 194:1-2, pages 77-84.
Crossref
Fabrice Piu, Michael Magnani & Max E Ader. (2002) Dissection of the cytoplasmic domains of cytokine receptors involved in STAT and Ras dependent proliferation. Oncogene 21:22, pages 3579-3591.
Crossref
Rizwan Haq, Adrienne Halupa, Bryan K. Beattie, Jacqueline M. Mason, Brent W. Zanke & Dwayne L. Barber. (2002) Regulation of Erythropoietin-induced STAT Serine Phosphorylation by Distinct Mitogen-activated Protein Kinases. Journal of Biological Chemistry 277:19, pages 17359-17366.
Crossref
Jess M. Cunnick, Songshu Meng, Yuan Ren, Caroline Desponts, Hong-Gang Wang, Julie Y. Djeu & Jie Wu. (2002) Regulation of the Mitogen-activated Protein Kinase Signaling Pathway by SHP2. Journal of Biological Chemistry 277:11, pages 9498-9504.
Crossref
M. Acevedo-Duncan, R. Patel, S. Whelan & E. Bicaku. (2002) Human glioma PKC-ι and PKC-βII phosphorylate cyclin-dependent kinase activating kinase during the cell cycle. Cell Proliferation 35:1, pages 23-36.
Crossref
Yu-Wen Zhang, Ling-Mei Wang, Richard Jove & George F Vande Woude. (2002) Requirement of Stat3 signaling for HGF/SF-Met mediated tumorigenesis. Oncogene 21:2, pages 217-226.
Crossref
Thomas E. Smithgall. 2002. Stem Cells: A Cellular Fountain of Youth. Stem Cells: A Cellular Fountain of Youth 1 18 .
Cynthia A. Heinlein & Chawnshang Chang. 2002. Androgens and Androgen Receptor. Androgens and Androgen Receptor 57 90 .
Shyamali Roy, Paul J. Ruest & Steven K. Hanks. (2002) FAK regulates tyrosine phosphorylation of CAS, paxillin, and PYK2 in cells expressing v-Src, but is not a critical determinant of v-Src transformation. Journal of Cellular Biochemistry 84:2, pages 377-388.
Crossref
Jennifer J. Westendorf. (2001) The Formin/Diaphanous-related Protein, FHOS, Interacts with Rac1 and Activates Transcription from the Serum Response Element. Journal of Biological Chemistry 276:49, pages 46453-46459.
Crossref
James Turkson, Declan Ryan, Joon S. Kim, Yi Zhang, Zhi Chen, Eric Haura, Andy Laudano, Said Sebti, Andrew D. Hamilton & Richard Jove. (2001) Phosphotyrosyl Peptides Block Stat3-mediated DNA Binding Activity, Gene Regulation, and Cell Transformation. Journal of Biological Chemistry 276:48, pages 45443-45455.
Crossref
Yiguo Zhang, Guangming Liu & Zigang Dong. (2001) MSK1 and JNKs Mediate Phosphorylation of STAT3 in UVA-irradiated Mouse Epidermal JB6 Cells. Journal of Biological Chemistry 276:45, pages 42534-42542.
Crossref
Salvador Aznar, Pilar F. Valerón, Sonia Victoria del Rincon, Leandro Fernández Pérez, Rosario Perona & Juan Carlos Lacal. (2001) Simultaneous Tyrosine and Serine Phosphorylation of STAT3 Transcription Factor Is Involved in Rho A GTPase Oncogenic Transformation. Molecular Biology of the Cell 12:10, pages 3282-3294.
Crossref
RuJu ChianSonia YoungAlla Danilkovitch-MiagkovaLars RönnstrandEdward LeonardPetranel FerraoLeonie AshmanDiana Linnekin. (2001) Phosphatidylinositol 3 kinase contributes to the transformation of hematopoietic cells by the D816V c-Kit mutant. Blood 98:5, pages 1365-1373.
Crossref
Tatjana R. Faruqi, Dolores Gomez, Xosé R. Bustelo, Dafna Bar-Sagi & Nancy C. Reich. (2001) Rac1 mediates STAT3 activation by autocrine IL-6. Proceedings of the National Academy of Sciences 98:16, pages 9014-9019.
Crossref
Tammy Bowman, Martin A. Broome, Dominic Sinibaldi, Walker Wharton, W. J. Pledger, John M. Sedivy, Rosalyn Irby, Timothy Yeatman, Sara A. Courtneidge & Richard Jove. (2001) Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis. Proceedings of the National Academy of Sciences 98:13, pages 7319-7324.
Crossref
Koji Abe, Manabu Hirai, Katsunori Mizuno, Natsuko Higashi, Toshihiro Sekimoto, Tokuhiko Miki, Toshio Hirano & Koichi Nakajima. (2001) The YXXQ motif in gp 130 is crucial for STAT3 phosphorylation at Ser727 through an H7-sensitive kinase pathway. Oncogene 20:27, pages 3464-3474.
Crossref
Cheh Peng Lim & Xinmin Cao. (2001) Regulation of Stat3 Activation by MEK Kinase 1. Journal of Biological Chemistry 276:24, pages 21004-21011.
Crossref
Stephanie Dehez, Laurence Daulhac, Aline Kowalski-Chauvel, Daniel Fourmy, Lucien Pradayrol & Catherine Seva. (2001) Gastrin-induced DNA synthesis requires p38-MAPK activation via PKC/Ca 2+ and Src-dependent mechanisms . FEBS Letters 496:1, pages 25-30.
Crossref
Christof R. Hauck, Tony Hunter & David D. Schlaepfer. (2001) The v-Src SH3 Domain Facilitates a Cell Adhesion-independent Association with Focal Adhesion Kinase. Journal of Biological Chemistry 276:21, pages 17653-17662.
Crossref
Magdalena Leszczyniecka, Terry Roberts, Paul Dent, Steven Grant & Paul B Fisher. (2001) Differentiation therapy of human cancer: basic science and clinical applications. Pharmacology & Therapeutics 90:2-3, pages 105-156.
Crossref
Prahlad T Ram & Ravi Iyengar. (2001) G protein coupled receptor signaling through the Src and Stat3 pathway: role in proliferation and transformation. Oncogene 20:13, pages 1601-1606.
Crossref
Scott D. Briggs, Beata Scholtz, Jean-Marc Jacque, Simon Swingler, Mario Stevenson & Thomas E. Smithgall. (2001) HIV-1 Nef Promotes Survival of Myeloid Cells by a Stat3-dependent Pathway. Journal of Biological Chemistry 276:27, pages 25605-25611.
Crossref
Jacqueline Bromberg & Xiaomin Chen. 2001. Regulators and Effectors of Small GTPases, Part G. Regulators and Effectors of Small GTPases, Part G 138 151 .
James Turkson & Richard Jove. (2000) STAT proteins: novel molecular targets for cancer drug discovery. Oncogene 19:56, pages 6613-6626.
Crossref
Yun Qiu & Hsing-Jien Kung. (2000) Signaling network of the Btk family kinases. Oncogene 19:49, pages 5651-5661.
Crossref
Sushil G Rane & E Premkumar Reddy. (2000) Janus kinases: components of multiple signaling pathways. Oncogene 19:49, pages 5662-5679.
Crossref
Dominic Sinibaldi, Walker Wharton, James Turkson, Tammy Bowman, Warren J Pledger & Richard Jove. (2000) Induction of p21WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts: role of activated STAT3 signaling. Oncogene 19:48, pages 5419-5427.
Crossref
Rafael F. Duarte & David A. Frank. (2000) SCF and G-CSF lead to the synergistic induction of proliferation and gene expression through complementary signaling pathways. Blood 96:10, pages 3422-3430.
Crossref
Rafael F. Duarte & David A. Frank. (2000) SCF and G-CSF lead to the synergistic induction of proliferation and gene expression through complementary signaling pathways. Blood 96:10, pages 3422-3430.
Crossref
Simi T. Ahmed & Lionel B. Ivashkiv. (2000) Inhibition of IL-6 and IL-10 Signaling and Stat Activation by Inflammatory and Stress Pathways. The Journal of Immunology 165:9, pages 5227-5237.
Crossref
Roberta ViscontiMassimo GadinaMario ChiarielloElbert H. ChenLouis F. StancatoJ. Silvio GutkindJohn J. O'Shea. (2000) Importance of the MKK6/p38 pathway for interleukin-12–induced STAT4 serine phosphorylation and transcriptional activity. Blood 96:5, pages 1844-1852.
Crossref
Roberta ViscontiMassimo GadinaMario ChiarielloElbert H. ChenLouis F. StancatoJ. Silvio GutkindJohn J. O'Shea. (2000) Importance of the MKK6/p38 pathway for interleukin-12–induced STAT4 serine phosphorylation and transcriptional activity. Blood 96:5, pages 1844-1852.
Crossref
Shahab Uddin, Fatima Lekmine, Niti Sharma, Beata Majchrzak, Ingrid Mayer, Peter R. Young, Gary M. Bokoch, Eleanor N. Fish & Leonidas C. Platanias. (2000) The Rac1/p38 Mitogen-activated Protein Kinase Pathway Is Required for Interferon α-dependent Transcriptional Activation but Not Serine Phosphorylation of Stat Proteins. Journal of Biological Chemistry 275:36, pages 27634-27640.
Crossref
Shangming Zhang & Mark H. Kaplan. (2000) The p38 Mitogen-Activated Protein Kinase Is Required for IL-12-Induced IFN-γ Expression. The Journal of Immunology 165:3, pages 1374-1380.
Crossref
David A. Hartley & Geoffrey M. Cooper. (2000) Direct Binding and Activation of STAT Transcription Factors by the Herpesvirus saimiri Protein Tip. Journal of Biological Chemistry 275:22, pages 16925-16932.
Crossref
James G. Karras, Robert A. McKay, Tao Lu, Jaclyn Pych, David A. Frank, Thomas L. Rothstein & Brett P. Monia. (2000) STAT3 Regulates the Growth and Immunoglobulin Production of BCL1 B Cell Lymphoma through Control of Cell Cycle Progression. Cellular Immunology 202:2, pages 124-135.
Crossref
Tammy Bowman, Roy Garcia, James Turkson & Richard Jove. (2000) STATs in oncogenesis. Oncogene 19:21, pages 2474-2488.
Crossref
Thomas Decker & Pavel Kovarik. (2000) Serine phosphorylation of STATs. Oncogene 19:21, pages 2628-2637.
Crossref
Paul J Coffer, Leo Koenderman & Rolf P de Groot. (2000) The role of STATs in myeloid differentiation and leukemia. Oncogene 19:21, pages 2511-2522.
Crossref
Thomas E Smithgall, Scott D Briggs, Steven Schreiner, Edwina C Lerner, Haiyun Cheng & Matthew B Wilson. (2000) Control of myeloid differentiation and survival by Stats. Oncogene 19:21, pages 2612-2618.
Crossref
Warren J. Leonard & Jian-Xin Lin. (2000) Cytokine receptor signaling pathways. Journal of Allergy and Clinical Immunology 105:5, pages 877-888.
Crossref
Michela C Rebsamen, Jean- François Arrighi, Cristiana E Juge-Aubry, Michel B Vallotton & Ursula Lang. (2000) Epidermal Growth Factor Induces Hypertrophic Responses and Stat5 Activation in Rat Ventricular Cardiomyocytes. Journal of Molecular and Cellular Cardiology 32:4, pages 599-610.
Crossref
Kazuroni Imada & Warren J Leonard. (2000) The Jak-STAT pathway. Molecular Immunology 37:1-2, pages 1-11.
Crossref
David A. Frank. (1999) STAT Signaling in the Pathogenesis and Treatment of Cancer. Molecular Medicine 5:7, pages 432-456.
Crossref

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