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Molecular and Cellular Biology Volume 19, 1999 - Issue 11
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Transcriptional Regulation

The Gal3p-Gal80p-Gal4p Transcription Switch of Yeast: Gal3p Destabilizes the Gal80p-Gal4p Complex in Response to Galactose and ATP

Alok Kumar Sil1 Department of Biochemistry and Molecular Biology
,
Samina Alam1 Department of Biochemistry and Molecular Biology
,
Ping Xin1 Department of Biochemistry and Molecular Biology
,
Ly Ma1 Department of Biochemistry and Molecular Biology
,
Melissa Morgan1 Department of Biochemistry and Molecular Biology
,
Colleen M. Lebo1 Department of Biochemistry and Molecular Biology
,
Michael P. Woods1 Department of Biochemistry and Molecular Biology;2 Intercollege Graduate Program in Genetics, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania17033
&
James E. Hopper1 Department of Biochemistry and Molecular Biology;2 Intercollege Graduate Program in Genetics, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania17033Correspondence[email protected]
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Pages 7828-7840 | Received 24 Mar 1999, Accepted 10 Aug 1999, Published online: 28 Mar 2023

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Onur Egriboz, Sudip Goswami, Xiaorong Tao, Kathleen Dotts, Christie Schaeffer, Vepkhia Pilauri & James E. Hopper. (2013) Self-Association of the Gal4 Inhibitor Protein Gal80 Is Impaired by Gal3: Evidence for a New Mechanism in the GAL Gene Switch. Molecular and Cellular Biology 33:18, pages 3667-3674.
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Gang Peng & James E. Hopper. (2000) Evidence for Gal3p's Cytoplasmic Location and Gal80p's Dual Cytoplasmic-Nuclear Location Implicates New Mechanisms for Controlling Gal4p Activity in Saccharomyces cerevisiae. Molecular and Cellular Biology 20:14, pages 5140-5148.
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John R. Rohde, Jennifer Trinh & Ivan Sadowski. (2000) Multiple Signals Regulate GALTranscription in Yeast. Molecular and Cellular Biology 20:11, pages 3880-3886.
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Xun Sun, Jing Yu, Cheng Zhu, Xinreng Mo, Qiangqiang Sun, Dandan Yang, Chang Su & Yang Lu. (2023) Recognition of galactose by a scaffold protein recruits a transcriptional activator for the GAL regulon induction in Candida albicans. eLife 12.
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Ebru Alazi, Claire Khosravi, Tim G. Homan, Saskia du Pré, Mark Arentshorst, Marcos Di Falco, Thi T. M. Pham, Mao Peng, Maria Victoria Aguilar-Pontes, Jaap Visser, Adrian Tsang, Ronald P. de Vries & Arthur F. J. Ram. (2017) The pathway intermediate 2-keto-3-deoxy-L-galactonate mediates the induction of genes involved in D-galacturonic acid utilization in Aspergillus niger . FEBS Letters 591:10, pages 1408-1418.
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Morten Roedgaard, Jacob Fredsoe, Jakob Madsen Pedersen, Lotte Bjergbaek & Anni Hangaard Andersen. (2015) DNA Topoisomerases Are Required for Preinitiation Complex Assembly during GAL Gene Activation. PLOS ONE 10:7, pages e0132739.
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Yi-Hyun Bae, Dae-Hyuk Kweon, Yong-Cheol Park & Jin-Ho Seo. (2014) Deletion of the HXK2 gene in Saccharomyces cerevisiae enables mixed sugar fermentation of glucose and galactose in oxygen-limited conditions. Process Biochemistry 49:4, pages 547-553.
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Sanjay K. Upadhyay. (2014) Dynamics of Gal80p in the Gal80p–Gal3p complex differ significantly from the dynamics in the Gal80p–Gal1p complex: implications for the higher specificity of Gal3p. Mol. BioSyst. 10:12, pages 3120-3129.
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Sanjay K. Upadhyay & Yellamraju U. Sasidhar. (2012) Molecular simulation and docking studies of Gal1p and Gal3p proteins in the presence and absence of ligands ATP and galactose: implication for transcriptional activation of GAL genes. Journal of Computer-Aided Molecular Design 26:7, pages 847-864.
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