Advanced search
Publication Cover
Molecular and Cellular Biology Volume 19, 1999 - Issue 11
Submit an article Journal homepage
15
Views
54
CrossRef citations to date
0
Altmetric
Mammalian Genetic Models with Minimal or Complex Phenotypes

Normal Skeletal Development of Mice Lacking Matrilin 1: Redundant Function of Matrilins in Cartilage?

Attila Aszódi1 Department of Experimental Pathology, Lund University, 221 85Lund, SwedenCorrespondence[email protected]
,
John F. Bateman1 Department of Experimental Pathology, Lund University, 221 85Lund, Sweden
,
Emilio Hirsch2 Department of Genetics, Biology and Biochemistry, University of Torino, 10126Torino, Italy
,
Mária Baranyi3 Agricultural Biotechnology Center, 2100Gödöllö, Hungary
,
Ernst B. Hunziker4 M.E. Müller Institute for Biomechanics, University of Bern, 3010Bern
,
Nik Hauser5 Department of Rheumatology, University Hospital Zürich, 8091Zürich, Switzerland
,
Zsuzsa Bösze3 Agricultural Biotechnology Center, 2100Gödöllö, Hungary
&
Reinhard Fässler1 Department of Experimental Pathology, Lund University, 221 85Lund, Sweden
 show all
Pages 7841-7845 | Received 22 Jul 1999, Accepted 03 Aug 1999, Published online: 28 Mar 2023

Citations (54)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (4)

Denitsa Docheva, Ernst B. Hunziker, Reinhard Fässler & Oliver Brandau. (2005) Tenomodulin Is Necessary for Tenocyte Proliferation and Tendon Maturation. Molecular and Cellular Biology 25:2, pages 699-705.
Read now
Yaping Ko, Birgit Kobbe, Claudia Nicolae, Nicolai Miosge, Mats Paulsson, Raimund Wagener & Attila Aszódi. (2004) Matrilin-3 Is Dispensable for Mouse Skeletal Growth and Development. Molecular and Cellular Biology 24:4, pages 1691-1699.
Read now
Oliver Brandau, Attila Aszódi, Ernst B. Hunziker, Peter J. Neame, Dietmar Vestweber & Reinhard Fässler. (2002) Chondromodulin I Is Dispensable during Enchondral Ossification and Eye Development. Molecular and Cellular Biology 22:18, pages 6627-6635.
Read now
Randall T. Clark, Tiffany L. Johnson, Benjamin J. Schalet, Lonnie Davis, Veronique Gaschen, Ernst B. Hunziker, Åke Oldberg & Borjana Mikic. (2001) GDF-5 Deficiency in Mice Leads to Disruption of Tail Tendon Form and Function. Connective Tissue Research 42:3, pages 175-186.
Read now

Articles from other publishers (50)

Anna E. Rapp & Frank Zaucke. (2023) Cartilage extracellular matrix-derived matrikines in osteoarthritis. American Journal of Physiology-Cell Physiology 324:2, pages C377-C394.
Crossref
Xiaopeng Wang, Guixin Li, Donglin Ruan, Zhanwei Zhuang, Rongrong Ding, Jianping Quan, Shiyuan Wang, Yongchuang Jiang, Jinyan Huang, Ting Gu, Linjun Hong, Enqin Zheng, Zicong Li, Gengyuan Cai, Zhenfang Wu & Jie Yang. (2022) Runs of Homozygosity Uncover Potential Functional-Altering Mutation Associated With Body Weight and Length in Two Duroc Pig Lines. Frontiers in Veterinary Science 9.
Crossref
Chao Wang, Biao Han, Bryan Kwok & Lin Han. 2022. Musculoskeletal Tissue Engineering. Musculoskeletal Tissue Engineering 133 166 .
Henning Madry, Susanne Grässel, Ulrich Nöth, Borna Relja, Anke Bernstein, Denitsa Docheva, Max Daniel Kauther, Jan Christoph Katthagen, Rainer Bader, Martijn van Griensven, Dieter C. Wirtz, Michael J. Raschke & Markus Huber-Lang. (2021) The future of basic science in orthopaedics and traumatology: Cassandra or Prometheus?. European Journal of Medical Research 26:1.
Crossref
Daphney R. Chery, Biao Han, Ying Zhou, Chao Wang, Sheila M. Adams, Prashant Chandrasekaran, Bryan Kwok, Su-Jin Heo, Motomi Enomoto-Iwamoto, X. Lucas Lu, Dehan Kong, Renato V. Iozzo, David E. Birk, Robert L. Mauck & Lin Han. (2021) Decorin regulates cartilage pericellular matrix micromechanobiology. Matrix Biology 96, pages 1-17.
Crossref
Elizabeth JohnstonMichael Buckley. (2020) Relative Protein Abundances and Biological Ageing in Whole Skeletal Elements. Journal of Proteome Research 20:1, pages 538-548.
Crossref
Ping Li, Lutz Fleischhauer, Claudia Nicolae, Carina Prein, Zsuzsanna Farkas, Maximilian Michael Saller, Wolf Christian Prall, Raimund Wagener, Juliane Heilig, Anja Niehoff, Hauke Clausen-Schaumann, Paolo Alberton & Attila Aszodi. (2020) Mice Lacking the Matrilin Family of Extracellular Matrix Proteins Develop Mild Skeletal Abnormalities and Are Susceptible to Age-Associated Osteoarthritis. International Journal of Molecular Sciences 21:2, pages 666.
Crossref
Guopan Tang, Weihua Lv, Zhipeng Sun, Dingchen Cao, Xianhu Zheng, Guangxiang Tong, Huanling Wang, Xiaofeng Zhang & Youyi Kuang. (2020) Heritability and quantitative trait locus analyses of intermuscular bones in mirror carp (Cyprinus carpio). Aquaculture 515, pages 734601.
Crossref
Pranita B. Balkhande, Bhaskar V.K.S. Lakkakula & Arun B. Chitharanjan. (2018) Relationship between matrilin-1 gene polymorphisms and mandibular retrognathism. American Journal of Orthodontics and Dentofacial Orthopedics 153:2, pages 255-261.e1.
Crossref
Mats Paulsson & Raimund Wagener. 2018. Methods in Extracellular Matrix Biology. Methods in Extracellular Matrix Biology 429 446 .
Lauryn N. Luderman, Gokhan Unlu & Ela W. Knapik. 2017. Zebrafish at the Interface of Development and Disease Research. Zebrafish at the Interface of Development and Disease Research 81 124 .
Hannah Uckelmann, Sandra Blaszkiewicz, Claudia Nicolae, Simon Haas, Alexandra Schnell, Stephan Wurzer, Raimund Wagener, Attila Aszodi & Marieke Alida Gertruda Essers. (2016) Extracellular matrix protein Matrilin-4 regulates stress-induced HSC proliferation via CXCR4. Journal of Experimental Medicine 213:10, pages 1961-1971.
Crossref
Frank Zaucke. 2016. Cartilage. Cartilage 55 81 .
Johanna Myllyharju. (2014) Extracellular Matrix and Developing Growth Plate. Current Osteoporosis Reports 12:4, pages 439-445.
Crossref
Cristian Dan Neacsu, Ya-Ping Ko, Andreas Tagariello, Kristina Røkenes Karlsen, Wolfram Friedrich Neiss, Mats Paulsson & Raimund Wagener. (2014) Matrilin-1 Is Essential for Zebrafish Development by Facilitating Collagen II Secretion. Journal of Biological Chemistry 289:3, pages 1505-1518.
Crossref
Tieshi LiLara LongobardiTimothy J. MyersJoseph D. TempleRonald L. ChandlerHuseyin OzkanClara ContaldoAnna Spagnoli. (2013) Joint TGF-β Type II Receptor-Expressing Cells: Ontogeny and Characterization as Joint Progenitors. Stem Cells and Development 22:9, pages 1342-1359.
Crossref
Peter A. Bell, Katarzyna A. Piróg, Maryline Fresquet, David J. Thornton, Raymond P. Boot‐Handford & Michael D. Briggs. (2012) Loss of matrilin 1 does not exacerbate the skeletal phenotype in a mouse model of multiple epiphyseal dysplasia caused by a Matn3 V194D mutation . Arthritis & Rheumatism 64:5, pages 1529-1539.
Crossref
Nicole Eitzinger, Cordula Surmann-Schmitt, Michael Bösl, Georg Schett, Klaus Engelke, Andreas Hess, Klaus von der Mark & Michael Stock. (2012) Ucma is not necessary for normal development of the mouse skeleton. Bone 50:3, pages 670-680.
Crossref
Elisa M. Nevalainen, Attila Braun, Maria K. Vartiainen, Martina Serlachius, Leif C. Andersson, Markus Moser & Pekka Lappalainen. (2011) Twinfilin-2a Is Dispensable for Mouse Development. PLoS ONE 6:8, pages e22894.
Crossref
Andreas R. Klatt, Ann-Kathrin A. Becker, Cristian D. Neacsu, Mats Paulsson & Raimund Wagener. (2011) The matrilins: Modulators of extracellular matrix assembly. The International Journal of Biochemistry & Cell Biology 43:3, pages 320-330.
Crossref
Maryline Fresquet, Thomas A. Jowitt, Louise A. Stephen, Joni Ylöstalo & Michael D. Briggs. (2010) Structural and Functional Investigations of Matrilin-1 A-domains Reveal Insights into Their Role in Cartilage ECM Assembly*. Journal of Biological Chemistry 285:44, pages 34048-34061.
Crossref
Annelies Dheedene, Steven Deleye, Jan Hellemans, Steven Staelens, Stefaan Vandenberghe & Geert Mortier. (2009) The Heterozygous Lemd3 +/GT Mouse Is Not a Murine Model for Osteopoikilosis in Humans. Calcified Tissue International 85:6, pages 546-551.
Crossref
Stephen Clark & David Rowe. 2008. Principles of Bone Biology. Principles of Bone Biology 1839 1855 .
Matthew P. Leighton, Seema Nundlall, Tobias Starborg, Roger S. Meadows, Farhana Suleman, Lynette Knowles, Raimund Wagener, David J. Thornton, Karl E. Kadler, Raymond P. Boot-Handford & Michael D. Briggs. (2007) Decreased chondrocyte proliferation and dysregulated apoptosis in the cartilage growth plate are key features of a murine model of epiphyseal dysplasia caused by a matn3 mutation. Human Molecular Genetics 16:14, pages 1728-1741.
Crossref
Claudia Nicolae, Ya-Ping Ko, Nicolai Miosge, Anja Niehoff, Daniel Studer, Lukas Enggist, Ernst B. Hunziker, Mats Paulsson, Raimund Wagener & Attila Aszodi. (2007) Abnormal Collagen Fibrils in Cartilage of Matrilin-1/Matrilin-3-deficient Mice. Journal of Biological Chemistry 282:30, pages 22163-22175.
Crossref
Gareth Hyde, Sharon Dover, Attila Aszodi, Gillian A. Wallis & Raymond P. Boot-Handford. (2007) Lineage tracing using matrilin-1 gene expression reveals that articular chondrocytes exist as the joint interzone forms. Developmental Biology 304:2, pages 825-833.
Crossref
Katsuaki Kanbe, Xu Yang, Lei Wei, Changqi Sun & Qian Chen. (2006) Pericellular Matrilins Regulate Activation of Chondrocytes by Cyclic Load-Induced Matrix Deformation. Journal of Bone and Mineral Research 22:2, pages 318-328.
Crossref
Louise van der Weyden, Lei Wei, Junming Luo, Xu Yang, David E. Birk, David J. Adams, Allan Bradley & Qian Chen. (2006) Functional Knockout of the Matrilin-3 Gene Causes Premature Chondrocyte Maturation to Hypertrophy and Increases Bone Mineral Density and Osteoarthritis. The American Journal of Pathology 169:2, pages 515-527.
Crossref
Su Hao Lo. (2006) Focal adhesions: What's new inside. Developmental Biology 294:2, pages 280-291.
Crossref
Raimund Wagener, Harald W.A. Ehlen, Ya-Ping Ko, Birgit Kobbe, Henning H. Mann, Gerhard Sengle & Mats Paulsson. (2005) The matrilins - adaptor proteins in the extracellular matrix. FEBS Letters 579:15, pages 3323-3329.
Crossref
Ya-Ping KO, Birgit KOBBE, Mats PAULSSON & Raimund WAGENER. (2005) Zebrafish ( Danio rerio ) matrilins: shared and divergent characteristics with their mammalian counterparts . Biochemical Journal 386:2, pages 367-379.
Crossref
Lajos Mátés, Claudia Nicolae, Matthias Mörgelin, Ferenc Deák, Ibolya Kiss & Attila Aszódi. (2004) Mice lacking the extracellular matrix adaptor protein matrilin-2 develop without obvious abnormalities. Matrix Biology 23:3, pages 195-204.
Crossref
Ildikó Karcagi, Tibor Rauch, László Hiripi, Otgonchimeg Rentsendorj, Andrea Nagy, Zsuzsa Bõsze & Ibolya Kiss. (2004) Functional analysis of the regulatory regions of the matrilin-1 gene in transgenic mice reveals modular arrangement of tissue-specific control elements. Matrix Biology 22:8, pages 605-618.
Crossref
Attila Aszodi, Ernst B. Hunziker, Cord Brakebusch & Reinhard Fässler. (2003) β1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis. Genes & Development 17:19, pages 2465-2479.
Crossref
Charles A. Whittaker & Richard O. Hynes. (2002) Distribution and Evolution of von Willebrand/Integrin A Domains: Widely Dispersed Domains with Roles in Cell Adhesion and Elsewhere. Molecular Biology of the Cell 13:10, pages 3369-3387.
Crossref
Dorothea Piecha, Karin Hartmann, Ingo Haase, Cornelia Mauch, Thomas Krieg, Birgit Kobbe & Mats Paulsson. (2002) Expression of Matrilin-2 in Human Skin. Journal of Investigative Dermatology 119:1, pages 38-43.
Crossref
Andreas R Klatt, Mats Paulsson & Raimund Wagener. (2002) Expression of matrilins during maturation of mouse skeletal tissues. Matrix Biology 21:3, pages 289-296.
Crossref
Lajos Mátés, Éva Korpos, Ferenc Deák, Zhanqin Liu, David R. Beier, Attila Aszódi & Ibolya Kiss. (2002) Comparative analysis of the mouse and human genes (Matn2 and MATN2) for matrilin-2, a filament-forming protein widely distributed in extracellular matrices. Matrix Biology 21:2, pages 163-174.
Crossref
Konrad Beck. 2002. Wiley Encyclopedia of Molecular Medicine. Wiley Encyclopedia of Molecular Medicine.
Stephen Clark & David Rowe. 2002. Principles of Bone Biology. Principles of Bone Biology 1491 1502 .
Mats Paulsson, Andreas R. Klatt, Birgit Kobbe, D. Patric Nitsche & Raimund Wagener. 2002. The Many Faces of Osteoarthritis. The Many Faces of Osteoarthritis 151 158 .
Ann-Sofie Hansson, Dick Heineg�rd, Jean-Charles Piette, Harald Burkhardt & Rikard Holmdahl. (2001) The occurrence of autoantibodies to matrilin 1 reflects a tissue-specific response to cartilage of the respiratory tract in patients with relapsing polychondritis. Arthritis & Rheumatism 44:10, pages 2402-2412.
Crossref
D. Segat, M. Paulsson & N. Smyth. (2001) Matrilins: structure, expression and function. Osteoarthritis and Cartilage 9, pages S29-S35.
Crossref
Kathryn L. Chapman, Geert R. Mortier, Kay Chapman, John Loughlin, Michael E. Grant & Michael D. Briggs. (2001) Mutations in the region encoding the von Willebrand factor A domain of matrilin-3 are associated with multiple epiphyseal dysplasia. Nature Genetics 28:4, pages 393-396.
Crossref
Andreas R. Klatt, D. Patric Nitsche, Birgit Kobbe, Marcus Macht, Mats Paulsson & Raimund Wagener. (2001) Molecular Structure, Processing, and Tissue Distribution of Matrilin-4. Journal of Biological Chemistry 276:20, pages 17267-17275.
Crossref
Anthony M. Reginato, WenFang Wang & Bjorn R. Olsen. 2001. Osteoporosis. Osteoporosis 189 212 .
Daniela Segat, Christian Frie, Patric D. Nitsche, Andreas R. Klatt, Dorothea Piecha, Eva Korpos, Ferenc Deák, Raimund Wagener, Mats Paulsson & Neil Smyth. (2000) Expression of matrilin-1, -2 and -3 in developing mouse limbs and heart. Matrix Biology 19:7, pages 649-655.
Crossref
Susan J. Monkley, Xiao-Hong Zhou, Sarah J. Kinston, Susan M. Giblett, Lance Hemmings, Helen Priddle, Jane E. Brown, Catrin A. Pritchard, David R. Critchley & Reinhard F�ssler. (2000) Disruption of thetalin gene arrests mouse development at the gastrulation stage. Developmental Dynamics 219:4, pages 560-574.
Crossref
Erika Gustafsson & Reinhard Fässler. (2000) Insights into Extracellular Matrix Functions from Mutant Mouse Models. Experimental Cell Research 261:1, pages 52-68.
Crossref
Attila Aszódi, John F. Bateman, Erika Gustafsson, Ray Boot-Handford & Reinhard Fässler. (2000) Mammalian Skeletogenesis and Extracellular Matrix. What can We Learn from Knockout Mice?. Cell Structure and Function 25:2, pages 73-84.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.