Advanced search
Publication Cover
Molecular and Cellular Biology Volume 19, 1999 - Issue 2
Submit an article Journal homepage
7
Views
67
CrossRef citations to date
0
Altmetric
Transcriptional Regulation

Activator-Specific Requirement of Yeast Mediator Proteins for RNA Polymerase II Transcriptional Activation

Sang Jun Han1 Center for Molecular Medicine, Samsung Biomedical Research Institute, Sungkyunkwan University College of Medicine, Seoul135-230, Korea
,
Young Chul Lee1 Center for Molecular Medicine, Samsung Biomedical Research Institute, Sungkyunkwan University College of Medicine, Seoul135-230, Korea
,
Byung Soo Gim1 Center for Molecular Medicine, Samsung Biomedical Research Institute, Sungkyunkwan University College of Medicine, Seoul135-230, Korea
,
Gi-Hyuck Ryu1 Center for Molecular Medicine, Samsung Biomedical Research Institute, Sungkyunkwan University College of Medicine, Seoul135-230, Korea
,
Soon Jung Park1 Center for Molecular Medicine, Samsung Biomedical Research Institute, Sungkyunkwan University College of Medicine, Seoul135-230, Korea
,
William S. Lane2 Harvard Microchemistry Facility, Harvard University, Cambridge, Massachusetts02138
&
Young-Joon Kim1 Center for Molecular Medicine, Samsung Biomedical Research Institute, Sungkyunkwan University College of Medicine, Seoul135-230, KoreaCorrespondence[email protected]
 show all
Pages 979-988 | Received 15 Sep 1998, Accepted 03 Nov 1998, Published online: 28 Mar 2023

Citations (67)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (12)

Thomas Eychenne, Michel Werner & Julie Soutourina. (2017) Toward understanding of the mechanisms of Mediator function in vivo: Focus on the preinitiation complex assembly. Transcription 8:5, pages 328-342.
Read now
Eric Herbig, Linda Warfield, Lisa Fish, James Fishburn, Bruce A. Knutson, Beth Moorefield, Derek Pacheco & Steven Hahn. (2010) Mechanism of Mediator Recruitment by Tandem Gcn4 Activation Domains and Three Gal11 Activator-Binding Domains. Molecular and Cellular Biology 30:10, pages 2376-2390.
Read now
Dae-Hwan Kim, Gwang Sik Kim, Chul Ho Yun & Young Chul Lee. (2008) Functional Conservation of the Glutamine-Rich Domains of Yeast Gal11 and Human SRC-1 in the Transactivation of Glucocorticoid Receptor Tau 1 in Saccharomyces cerevisiae. Molecular and Cellular Biology 28:3, pages 913-925.
Read now
Christophe Leroy, Laëtitia Cormier & Laurent Kuras. (2006) Independent Recruitment of Mediator and SAGA by the Activator Met4. Molecular and Cellular Biology 26:8, pages 3149-3163.
Read now
Fan Zhang, Laarni Sumibcay, Alan G. Hinnebusch & Mark J. Swanson. (2004) A Triad of Subunits from the Gal11/Tail Domain of Srb Mediator Is an In Vivo Target of Transcriptional Activator Gcn4p. Molecular and Cellular Biology 24:15, pages 6871-6886.
Read now
Jin Mo Park, Jung Mo Kim, Lark Kyun Kim, Se Nyun Kim, Jeongsil Kim-Ha, Jung Hoe Kim & Young-Joon Kim. (2003) Signal-Induced Transcriptional Activation by Dif Requires the dTRAP80 Mediator Module. Molecular and Cellular Biology 23:4, pages 1358-1367.
Read now
Byung Soo Gim, Jin Mo Park, Jeong Ho Yoon, Changwon Kang & Young-Joon Kim. (2001) Drosophila Med6 Is Required for Elevated Expression of a Large but Distinct Set of Developmentally Regulated Genes. Molecular and Cellular Biology 21:15, pages 5242-5255.
Read now
Gang Wang, Greg T. Cantin, Jennitte L. Stevens & Arnold J. Berk. (2001) Characterization of Mediator Complexes from HeLa Cell Nuclear Extract. Molecular and Cellular Biology 21:14, pages 4604-4613.
Read now
Jin Mo Park, Hye-Suk Kim, Sang Jun Han, Moon-Sun Hwang, Young Chul Lee & Young-Joon Kim. (2000) In Vivo Requirement of Activator-Specific Binding Targets of Mediator. Molecular and Cellular Biology 20:23, pages 8709-8719.
Read now
Sungjoon Kim, Kettly Cabane, Michael Hampsey & Danny Reinberg. (2000) Genetic Analysis of the Ydr1-Bur6 Repressor Complex Reveals an Intricate Balance among Transcriptional Regulatory Proteins in Yeast. Molecular and Cellular Biology 20:7, pages 2455-2465.
Read now
K. Yankulov, I. Todorov, P. Romanowski, D. Licatalosi, K. Cilli, S. McCracken, R. Laskey & D. L. Bentley. (1999) MCM Proteins Are Associated with RNA Polymerase II Holoenzyme. Molecular and Cellular Biology 19:9, pages 6154-6163.
Read now
Young Chul Lee, Jin Mo Park, Soyoung Min, Sang Jun Han & Young-Joon Kim. (1999) An Activator Binding Module of Yeast RNA Polymerase II Holoenzyme. Molecular and Cellular Biology 19:4, pages 2967-2976.
Read now

Articles from other publishers (55)

Wenhan Yang, Kaiping Gao, Youhui Qian, Yongyi Huang, Qin Xiang, Cheng Chen, Qianqian Chen, Yiling Wang, Fuyuan Fang, Qihan He, Siqi Chen, Juan Xiong, Yangchao Chen, Ni Xie, Duo Zheng & Rihong Zhai. (2022) A novel tRNA-derived fragment AS-tDR-007333 promotes the malignancy of NSCLC via the HSPB1/MED29 and ELK4/MED29 axes. Journal of Hematology & Oncology 15:1.
Crossref
William B. Gurley, Kevin O'Grady, Eva Czarnecka-Verner & Shai J. Lawit. 2018. Annual Plant Reviews online. Annual Plant Reviews online 1 27 .
Gwang Sik Kim & Young Chul Lee. (2018) Postrecruitment Function of Yeast Med6 Protein during the Transcriptional Activation by Mediator Complex. Biochemistry Research International 2018, pages 1-9.
Crossref
Kayo Nozawa, Thomas R. Schneider & Patrick Cramer. (2017) Core Mediator structure at 3.4 Å extends model of transcription initiation complex. Nature 545:7653, pages 248-251.
Crossref
Thomas Eychenne, Elizaveta Novikova, Marie-Bénédicte Barrault, Olivier Alibert, Claire Boschiero, Nuno Peixeiro, David Cornu, Virginie Redeker, Laurent Kuras, Pierre Nicolas, Michel Werner & Julie Soutourina. (2016) Functional interplay between Mediator and TFIIB in preinitiation complex assembly in relation to promoter architecture. Genes & Development 30:18, pages 2119-2132.
Crossref
Maria J. Aristizabal, Gian Luca Negri, Joris J. Benschop, Frank C. P. Holstege, Nevan J. Krogan & Michael S. Kobor. (2013) High-Throughput Genetic and Gene Expression Analysis of the RNAPII-CTD Reveals Unexpected Connections to SRB10/CDK8. PLoS Genetics 9:8, pages e1003758.
Crossref
Miriam Larsson, Hanna Uvell, Jenny Sandström, Patrik Rydén, Luke A. Selth & Stefan Björklund. (2013) Functional Studies of the Yeast Med5, Med15 and Med16 Mediator Tail Subunits. PLoS ONE 8:8, pages e73137.
Crossref
Suraiya A. Ansari & Randall H. Morse. (2013) Mechanisms of Mediator complex action in transcriptional activation. Cellular and Molecular Life Sciences 70:15, pages 2743-2756.
Crossref
Jing Peng & Jin-Qiu Zhou. (2012) The tail-module of yeast Mediator complex is required for telomere heterochromatin maintenance. Nucleic Acids Research 40:2, pages 581-593.
Crossref
Riina Kuuselo, Kimmo Savinainen, Saana Sandström, Reija Autio & Anne Kallioniemi. (2011) MED29, a component of the mediator complex, possesses both oncogenic and tumor suppressive characteristics in pancreatic cancer. International Journal of Cancer 129:11, pages 2553-2565.
Crossref
Martin Seizl, Laurent Larivière, Toni Pfaffeneder, Larissa Wenzeck & Patrick Cramer. (2011) Mediator head subcomplex Med11/22 contains a common helix bundle building block with a specific function in transcription initiation complex stabilization. Nucleic Acids Research 39:14, pages 6291-6304.
Crossref
Carlyle Rogers, Zhenhua Guo & John W. Stiller. (2010) Connecting Mutations of the RNA Polymerase II C-Terminal Domain to Complex Phenotypic Changes Using Combined Gene Expression and Network Analyses. PLoS ONE 5:6, pages e11386.
Crossref
Suraiya A. Ansari, Qiye He & Randall H. Morse. (2009) Mediator complex association with constitutively transcribed genes in yeast. Proceedings of the National Academy of Sciences 106:39, pages 16734-16739.
Crossref
Susanne Hagist, Holger Sültmann, Gunda Millonig, Ulrike Hebling, Dörthe Kieslich, Rupert Kuner, Sabrina Balaguer, Helmut-Karl Seitz, Annemarie Poustka & Sebastian Mueller. (2009) In vitro-targeted gene identification in patients with hepatitis C using a genome-wide microarray technology. Hepatology 49:2, pages 378-386.
Crossref
Hiroyuki Takahashi, Koji Kasahara & Tetsuro Kokubo. (2009) Saccharomyces cerevisiae Med9 comprises two functionally distinct domains that play different roles in transcriptional regulation . Genes to Cells 14:1, pages 53-67.
Crossref
Cyril Esnault, Yad Ghavi-Helm, Sylvain Brun, Julie Soutourina, Nynke Van Berkum, Claire Boschiero, Frank Holstege & Michel Werner. (2008) Mediator-Dependent Recruitment of TFIIH Modules in Preinitiation Complex. Molecular Cell 31:3, pages 337-346.
Crossref
Qiye He, Luisa Battistella & Randall H. Morse. (2008) Mediator Requirement Downstream of Chromatin Remodeling during Transcriptional Activation of CHA1 in Yeast. Journal of Biological Chemistry 283:9, pages 5276-5286.
Crossref
Mikhail Martchenko, Anastasia Levitin & Malcolm Whiteway. (2007) Transcriptional Activation Domains of the Candida albicans Gcn4p and Gal4p Homologs . Eukaryotic Cell 6:2, pages 291-301.
Crossref
Shamara M. Baidoobonso, Benjamin W. Guidi & Lawrence C. Myers. (2007) Med19(Rox3) Regulates Intermodule Interactions in the Saccharomyces cerevisiae Mediator Complex. Journal of Biological Chemistry 282:8, pages 5551-5559.
Crossref
Sylvie Lallet, Hervé Garreau, Cecilia Garmendia-Torres, Dagmara Szestakowska, Emmanuelle Boy-Marcotte, Sophie Quevillon-Chéruel & Michel Jacquet. (2006) Role of Gal11, a component of the RNA polymerase II mediator in stress-induced hyperphosphorylation of Msn2 in Saccharomyces cerevisiae . Molecular Microbiology 62:2, pages 438-452.
Crossref
Magnus Hallberg, Guo-Zhen Hu, Susanna Tronnersjö, David Adler, Darius Balciunas, Stefan Björklund & Hans Ronne. (2006) Functional and physical interactions within the middle domain of the yeast mediator. Molecular Genetics and Genomics 276:2, pages 197-210.
Crossref
Harpreet Singh, Alexander M Erkine, Selena B Kremer, Harry M Duttweiler, Donnie A Davis, Jabed Iqbal, Rachel R Gross & David S Gross. (2006) A Functional Module of Yeast Mediator That Governs the Dynamic Range of Heat-Shock Gene Expression. Genetics 172:4, pages 2169-2184.
Crossref
Prasanna Alluri, Bo Liu, Peng Yu, Xiangshu Xiao & Thomas Kodadek. (2006) Isolation and characterization of coactivator-binding peptoids from a combinatorial library. Molecular BioSystems 2:11, pages 568.
Crossref
Kristi L. Penheiter & Judith A. Jaehning. 2006. Gene Expression and Regulation. Gene Expression and Regulation 49 66 .
Kailash Gulshan, Sherry A. Rovinsky, Sean T. Coleman & W. Scott Moye-Rowley. (2005) Oxidant-specific Folding of Yap1p Regulates Both Transcriptional Activation and Nuclear Localization. Journal of Biological Chemistry 280:49, pages 40524-40533.
Crossref
Young-Joon Kim & John T. Lis. (2005) Interactions between subunits of Drosophila Mediator and activator proteins. Trends in Biochemical Sciences 30:5, pages 245-249.
Crossref
Tae Whan Kim, Yong-Jae Kwon, Jung Mo Kim, Young-Hwa Song, Se Nyun Kim & Young-Joon Kim. (2004) MED16 and MED23 of Mediator are coactivators of lipopolysaccharide- and heat-shock-induced transcriptional activators. Proceedings of the National Academy of Sciences 101:33, pages 12153-12158.
Crossref
Julián Nevado, Stephan P Tenbaum & Ana Aranda. (2004) hSrb7, an essential human Mediator component, acts as a coactivator for the thyroid hormone receptor. Molecular and Cellular Endocrinology 222:1-2, pages 41-51.
Crossref
Stefan Björklund & Claes M Gustafsson. 2004. Proteins in Eukaryotic Transcription. Proteins in Eukaryotic Transcription 43 65 .
Greg T. Cantin, Jennitte L. Stevens & Arnold J. Berk. (2003) Activation domain–mediator interactions promote transcription preinitiation complex assembly on promoter DNA. Proceedings of the National Academy of Sciences 100:21, pages 12003-12008.
Crossref
Brian A. Lewis & Danny Reinberg. (2003) The mediator coactivator complex: functional and physical roles in transcriptional regulation. Journal of Cell Science 116:18, pages 3667-3675.
Crossref
Darius Balciunas, Magnus Hallberg, Stefan Björklund & Hans Ronne. (2003) Functional Interactions within Yeast Mediator and Evidence of Differential Subunit Modifications. Journal of Biological Chemistry 278:6, pages 3831-3839.
Crossref
Laura Gauthier, Renata Dziak, David J H Kramer, David Leishman, Xiaomin Song, Jason Ho, Maja Radovic, David Bentley & Krassimir Yankulov. (2002) The Role of the Carboxyterminal Domain of RNA Polymerase II in Regulating Origins of DNA Replication in Saccharomyces cerevisiae . Genetics 162:3, pages 1117-1129.
Crossref
Linda Holland, Michael Downey, Xiaomin Song, Laura Gauthier, Patricia Bell-Rogers & Krassimir Yankulov. (2002) Distinct parts of minichromosome maintenance protein 2 associate with histone H3/H4 and RNA polymerase II holoenzyme. European Journal of Biochemistry 269:21, pages 5192-5202.
Crossref
Eun Yong Shim, Amy K. Walker & T. Keith Blackwell. (2002) Broad Requirement for the Mediator Subunit RGR-1 for Transcription in the Caenorhabditis elegans Embryo. Journal of Biological Chemistry 277:34, pages 30413-30416.
Crossref
Muriel Boube, Laurent Joulia, David L. Cribbs & Henri-Marc Bourbon. (2002) Evidence for a Mediator of RNA Polymerase II Transcriptional Regulation Conserved from Yeast to Man. Cell 110:2, pages 143-151.
Crossref
Zhen Lu, Aseem Z. Ansari, Xiangyang Lu, Anuja Ogirala & Mark Ptashne. (2002) A target essential for the activity of a nonacidic yeast transcriptional activator. Proceedings of the National Academy of Sciences 99:13, pages 8591-8596.
Crossref
Mario Mencı́a, Zarmik Moqtaderi, Joseph V Geisberg, Laurent Kuras & Kevin Struhl. (2002) Activator-Specific Recruitment of TFIID and Regulation of Ribosomal Protein Genes in Yeast. Molecular Cell 9:4, pages 823-833.
Crossref
Alan G. Hinnebusch & Krishnamurthy Natarajan. (2002) Gcn4p, a Master Regulator of Gene Expression, Is Controlled at Multiple Levels by Diverse Signals of Starvation and Stress. Eukaryotic Cell 1:1, pages 22-32.
Crossref
Jong Seok Kang, Seung Hyun Kim, Moon Sun Hwang, Sang Jun Han, Young Chul Lee & Young-Joon Kim. (2001) The Structural and Functional Organization of the Yeast Mediator Complex. Journal of Biological Chemistry 276:45, pages 42003-42010.
Crossref
Sang Jun Han, Jung-Soon Lee, Jong Seok Kang & Young-Joon Kim. (2001) Med9/Cse2 and Gal11 Modules Are Required for Transcriptional Repression of Distinct Group of Genes. Journal of Biological Chemistry 276:40, pages 37020-37026.
Crossref
Leena T. Bhoite, Yaxin Yu & David J. Stillman. (2001) The Swi5 activator recruits the Mediator complex to the HO promoter without RNA polymerase II . Genes & Development 15:18, pages 2457-2469.
Crossref
M. Sipiczki. (2001) Identification of Schizosaccharomyces pombe genes that encode putative homolgues of Saccharomyces cerevisiae mediator complex subunits . Acta Microbiologica et Immunologica Hungarica 48:3-4, pages 519-531.
Crossref
Susie C Howard, Ya-Wen Chang, Yelena V Budovskaya & Paul K Herman. (2001) The Ras/PKA Signaling Pathway of Saccharomyces cerevisiae Exhibits a Functional Interaction With the Sin4p Complex of the RNA Polymerase II Holoenzyme . Genetics 159:1, pages 77-89.
Crossref
Choon-Ju Jeong, Sang-Hwa Yang, Yueqing Xie, Lei Zhang, Stephen Albert Johnston & Thomas Kodadek. (2001) Evidence That Gal11 Protein Is a Target of the Gal4 Activation Domain in the Mediator. Biochemistry 40:31, pages 9421-9427.
Crossref
Claes M. Gustafsson & Tore Samuelsson. (2001) Mediator - a universal complex in transcriptional regulation. Molecular Microbiology 41:1, pages 1-8.
Crossref
Ying Liu, Jeffrey A. Ranish, Ruedi Aebersold & Steven Hahn. (2001) Yeast Nuclear Extract Contains Two Major Forms of RNA Polymerase II Mediator Complexes. Journal of Biological Chemistry 276:10, pages 7169-7175.
Crossref
Ya-Wen Chang, Susie C Howard, Yelena V Budovskaya, Jasper Rine & Paul K Herman. (2001) The rye Mutants Identify a Role for Ssn/Srb Proteins of the RNA Polymerase II Holoenzyme During Stationary Phase Entry in Saccharomyces cerevisiae . Genetics 157:1, pages 17-26.
Crossref
Anne Gromöller & Norbert Lehming. (2000) Srb7p is essential for the activation of a subset of genes. FEBS Letters 484:1, pages 48-54.
Crossref
Patrick J Costa & Karen M Arndt. (2000) Synthetic Lethal Interactions Suggest a Role for the Saccharomyces cerevisiae Rtf1 Protein in Transcription Elongation . Genetics 156:2, pages 535-547.
Crossref
Lawrence C. Myers & Roger D. Kornberg. (2000) Mediator of Transcriptional Regulation. Annual Review of Biochemistry 69:1, pages 729-749.
Crossref
Stephen Buratowski. (2000) Snapshots of RNA polymerase II transcription initiation. Current Opinion in Cell Biology 12:3, pages 320-325.
Crossref
Eric D Ross, Anne M Keating & L.James MaherIIIIII. (2000) DNA constraints on transcription activation in Vitro. Journal of Molecular Biology 297:2, pages 321-334.
Crossref
Jae Young Kwon, Jin Mo Park, Byung Soo Gim, Sang Jun Han, Junho Lee & Young-Joon Kim. (1999) Caenorhabditis elegans Mediator complexes are required for developmental-specific transcriptional activation . Proceedings of the National Academy of Sciences 96:26, pages 14990-14995.
Crossref
Krishnamurthy Natarajan, Belinda M Jackson, Heng Zhou, Fred Winston & Alan G Hinnebusch. (1999) Transcriptional Activation by Gcn4p Involves Independent Interactions with the SWI/SNF Complex and the SRB/Mediator. Molecular Cell 4:4, pages 657-664.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.