18
Views
141
CrossRef citations to date
0
Altmetric
Cell Growth and Development

p70 S6 Kinase Is Regulated by Protein Kinase Cζ and Participates in a Phosphoinositide 3-Kinase-Regulated Signalling Complex

, , &
Pages 2921-2928 | Received 19 Oct 1998, Accepted 21 Dec 1998, Published online: 28 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (10)

Yang Ni, Francesco C. Stingo & Veerabhadran Baladandayuthapani. (2017) Sparse Multi-Dimensional Graphical Models: A Unified Bayesian Framework. Journal of the American Statistical Association 112:518, pages 779-793.
Read now
Bing Su & Estela Jacinto. (2011) Mammalian TOR signaling to the AGC kinases. Critical Reviews in Biochemistry and Molecular Biology 46:6, pages 527-547.
Read now
Linda S Steelman, Kristin M Stadelman, William H Chappell, Stefan Horn, Jörg Bäsecke, Melchiorre Cervello, Ferdinando Nicoletti, Massimo Libra, Franca Stivala, Alberto M Martelli & James A McCubrey. (2008) Akt as a therapeutic target in cancer. Expert Opinion on Therapeutic Targets 12:9, pages 1139-1165.
Read now
Katarzyna Jastrzebski, Katherine M. Hannan, Elissaveta B. Tchoubrieva, Ross D. Hannan & Richard B. Pearson. (2007) Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function. Growth Factors 25:4, pages 209-226.
Read now
Jong Hyun Kim, Jung Hwan Kim, Motoi Ohba, Pann-Ghill Suh & Sung Ho Ryu. (2005) Novel Functions of the Phospholipase D2-Phox Homology Domain in Protein Kinase Cζ Activation. Molecular and Cellular Biology 25:8, pages 3194-3208.
Read now
Gabriella Castoria, Antimo Migliaccio, Marina Di Domenico, Maria Lombardi, Antonietta de Falco, Lilian Varricchio, Antonio Bilancio, Maria Vittoria Barone & Ferdinando Auricchio. (2004) Role of Atypical Protein Kinase C in Estradiol-Triggered G1/S Progression of MCF-7 Cells. Molecular and Cellular Biology 24:17, pages 7643-7653.
Read now
Taras Valovka, Frederique Verdier, Rainer Cramer, Alexander Zhyvoloup, Timothy Fenton, Heike Rebholz, Mong-Lien Wang, Miechyslav Gzhegotsky, Alexander Lutsyk, Genadiy Matsuka, Valeriy Filonenko, Lijun Wang, Christopher G. Proud, Peter J. Parker & Ivan T. Gout. (2003) Protein Kinase C Phosphorylates Ribosomal Protein S6 Kinase βII and Regulates Its Subcellular Localization. Molecular and Cellular Biology 23:3, pages 852-863.
Read now
Hua Tang, Eran Hornstein, Miri Stolovich, Galit Levy, Mark Livingstone, Dennis Templeton, Joseph Avruch & Oded Meyuhas. (2001) Amino Acid-Induced Translation of TOP mRNAs Is Fully Dependent on Phosphatidylinositol 3-Kinase-Mediated Signaling, Is Partially Inhibited by Rapamycin, and Is Independent of S6K1 and rpS6 Phosphorylation. Molecular and Cellular Biology 21:24, pages 8671-8683.
Read now
Kevin C. Corbit, Jae-Won Soh, Keiko Yoshida, Eva M. Eves, I. Bernard Weinstein & Marsha Rich Rosner. (2000) Different Protein Kinase C Isoforms Determine Growth Factor Specificity in Neuronal Cells. Molecular and Cellular Biology 20:15, pages 5392-5403.
Read now
Matthew P. Coghlan, Margaret M. Chou & Christopher L. Carpenter. (2000) Atypical Protein Kinases Cλ and -ζ Associate with the GTP-Binding Protein Cdc42 and Mediate Stress Fiber Loss. Molecular and Cellular Biology 20:8, pages 2880-2889.
Read now

Articles from other publishers (131)

Raheel Khan, D. Kulasiri & S. Samarasinghe. (2023) A multifarious exploration of synaptic tagging and capture hypothesis in synaptic plasticity: Development of an integrated mathematical model and computational experiments. Journal of Theoretical Biology 556, pages 111326.
Crossref
Masaw Akbari, Jonathan D. West, Nicholas Doerr, Kevin R. Kipp, Neda Marhamati, Sabrina Vuong, Yidi Wang, Markus M. Rinschen, Jeffrey J. Talbot, Oliver Wessely & Thomas Weimbs. (2022) Restoration of atypical protein kinase C ζ function in autosomal dominant polycystic kidney disease ameliorates disease progression. Proceedings of the National Academy of Sciences 119:30.
Crossref
Jaime James, Yifei Chen, Clara M Hernandez, Florian Forster, Markus Dagnell, Qing Cheng, Amir A Saei, Hassan Gharibi, Gonzalo Fernandez Lahore, Annika Åstrand, Rajneesh Malhotra, Bernard Malissen, Roman A Zubarev, Elias SJ Arnér & Rikard Holmdahl. (2022) Redox regulation of PTPN22 affects the severity of T-cell-dependent autoimmune inflammation. eLife 11.
Crossref
Claudio D’Incal, Jitse Broos, Thierry Torfs, R. Frank Kooy & Wim Vanden Berghe. (2022) Towards Kinase Inhibitor Therapies for Fragile X Syndrome: Tweaking Twists in the Autism Spectrum Kinase Signaling Network. Cells 11:8, pages 1325.
Crossref
Akihiro Ishii, Miki Furusho, Wendy Macklin & Rashmi Bansal. (2019) Independent and cooperative roles of the Mek/ERK1/2‐MAPK and PI3K/Akt/mTOR pathways during developmental myelination and in adulthood. Glia 67:7, pages 1277-1295.
Crossref
Sheikh Tahir Majeed, Rabiya Majeed, Ghazia Shah & Khurshid I Andrabi. 2019. Homeostasis - An Integrated Vision. Homeostasis - An Integrated Vision.
G G Jinesh, V Sambandam, S Vijayaraghavan, K Balaji & S Mukherjee. (2017) Molecular genetics and cellular events of K-Ras-driven tumorigenesis. Oncogene 37:7, pages 839-846.
Crossref
Fatemeh Zahedipour, Razieh Dalirfardouei, Gholamreza Karimi & Khadijeh Jamialahmadi. (2017) Molecular mechanisms of anticancer effects of Glucosamine. Biomedicine & Pharmacotherapy 95, pages 1051-1058.
Crossref
Kristen T. Crowell, Jennifer L. Steiner, Catherine S. Coleman & Charles H. Lang. (2016) Decreased Whole-Body Fat Mass Produced by Chronic Alcohol Consumption is Associated with Activation of S6K1-Mediated Protein Synthesis and Increased Autophagy in Epididymal White Adipose Tissue. Alcoholism: Clinical and Experimental Research 40:9, pages 1832-1845.
Crossref
Jayalakshmi Lakshmipathi, Juan Carlos Alvarez-Perez, Carolina Rosselot, Gabriella P. Casinelli, Rachel E. Stamateris, Francisco Rausell-Palamos, Christopher P. O’Donnell, Rupangi C. Vasavada, Donald K. Scott, Laura C. Alonso & Adolfo Garcia-Ocaña. (2016) PKCζ Is Essential for Pancreatic β-Cell Replication During Insulin Resistance by Regulating mTOR and Cyclin-D2. Diabetes 65:5, pages 1283-1296.
Crossref
Goodwin G. Jinesh, Rikiya Taoka, Qiang Zhang, Siddharth Gorantla & Ashish M. Kamat. (2016) Novel PKC-ζ to p47phox interaction is necessary for transformation from blebbishields. Scientific Reports 6:1.
Crossref
Yunqian Peng, Ji-Min Kim, Hal-Sol Park, Annie Yang, Celia Islam, Edward G. Lakatta & Li Lin. (2016) AGE-RAGE signal generates a specific NF-κB RelA “barcode” that directs collagen I expression. Scientific Reports 6:1.
Crossref
Jaya Padmanabhan, Kristy R. Brown, Amelia Padilla & Michael L. Shelanski. (2015) Functional Role of RNA Polymerase II and P70 S6 Kinase in KCl Withdrawal-induced Cerebellar Granule Neuron Apoptosis. Journal of Biological Chemistry 290:9, pages 5267-5279.
Crossref
Suchithra Menon, Christian C. Dibble, George Talbott, Gerta Hoxhaj, Alexander J. Valvezan, Hidenori Takahashi, Lewis C. Cantley & Brendan D. Manning. (2014) Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome. Cell 156:4, pages 771-785.
Crossref
Mohamad El Osta, Mengling Liu, Mohamad Adada, Can E. Senkal, Jolanta Idkowiak‐Baldys, Lina M. Obeid, Christopher J. Clarke & Yusuf A. Hannun. (2013) Sustained PKCβII activity confers oncogenic properties in a phospholipase D‐ and mTOR‐dependent manner. The FASEB Journal 28:1, pages 495-505.
Crossref
Jennifer C Darnell & Eric Klann. (2013) The translation of translational control by FMRP: therapeutic targets for FXS. Nature Neuroscience 16:11, pages 1530-1536.
Crossref
Joanna Roszak, Anna Smok-Pieniążek, Marek Nocuń & Maciej Stępnik. (2013) Characterization of arsenic trioxide resistant clones derived from Jurkat leukemia T cell line: Focus on PI3K/Akt signaling pathway. Chemico-Biological Interactions 205:3, pages 198-211.
Crossref
Seong-il Lee, Weibing Zhang, Mayuri Ravi, Markus Weschenfelder, Martin Bastmeyer & Joel M. Levine. (2013) Atypical Protein Kinase C and Par3 Are Required for Proteoglycan-Induced Axon Growth Inhibition. The Journal of Neuroscience 33:6, pages 2541-2554.
Crossref
Rana Anjum, Eunice Pae, John Blenis & Bryan A. Ballif. (2012) TPCK inhibits AGC kinases by direct activation loop adduction at phenylalanine-directed cysteine residues. FEBS Letters 586:19, pages 3471-3476.
Crossref
Brian MagnusonBilgen EkimDiane C. Fingar. (2011) Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks. Biochemical Journal 441:1, pages 1-21.
Crossref
Silvia Velazquez-Garcia, Shelley Valle, Taylor C. Rosa, Karen K. Takane, Cem Demirci, Juan C. Alvarez-Perez, Jose M. Mellado-Gil, Sara Ernst, Donald K. Scott, Rupangi C. Vasavada, Laura C. Alonso & Adolfo Garcia-Ocaña. (2011) Activation of Protein Kinase C-ζ in Pancreatic β-Cells In Vivo Improves Glucose Tolerance and Induces β-Cell Expansion via mTOR Activation. Diabetes 60:10, pages 2546-2559.
Crossref
Honghui Guo, Dan Li, Wenhua Ling, Xiang Feng & Min Xia. (2011) Anthocyanin inhibits high glucose-induced hepatic mtGPAT1 activation and prevents fatty acid synthesis through PKCζ. Journal of Lipid Research 52:5, pages 908-922.
Crossref
Natalie R. Leach & Richard J. Roller. (2010) Significance of host cell kinases in herpes simplex virus type 1 egress and lamin-associated protein disassembly from the nuclear lamina. Virology 406:1, pages 127-137.
Crossref
Cédric M. BlouinCécilia PradoKaren K. TakaneFrançoise LasnierAdolfo Garcia-OcanaPascal FerréIsabelle DugailEric Hajduch. (2010) Plasma Membrane Subdomain Compartmentalization Contributes to Distinct Mechanisms of Ceramide Action on Insulin Signaling. Diabetes 59:3, pages 600-610.
Crossref
Robert V. Farese & Mini P. Sajan. (2010) Metabolic functions of atypical protein kinase C: “good” and “bad” as defined by nutritional status. American Journal of Physiology-Endocrinology and Metabolism 298:3, pages E385-E394.
Crossref
Raju V.S Rajala. (2010) Phosphoinositide 3-kinase signaling in the vertebrate retina. Journal of Lipid Research 51:1, pages 4-22.
Crossref
Zhi-Sheng JiangGe-Bo WenZhi-Han TangWattamon SrisakuldeeRobert R. FandrichElissavet Kardami. (2009) High molecular weight FGF-2 promotes postconditioning-like cardioprotection linked to activation of the protein kinase C isoforms Akt and p70 S6 kinaseThis article is one of a selection of papers published in a special issue celebrating the 125th anniversary of the Faculty of Medicine at the University of Manitoba.. Canadian Journal of Physiology and Pharmacology 87:10, pages 798-804.
Crossref
Elena M. Rodriguez, Elizabeth E. Dunham & G. Steven Martin. (2009) Atypical protein kinase C activity is required for extracellular matrix degradation and invasion by Src-transformed cells. Journal of Cellular Physiology 221:1, pages 171-182.
Crossref
Antonella Sacco, Alaide Morcavallo, Giuseppe Pandini, Riccardo Vigneri & Antonino Belfiore. (2009) Differential Signaling Activation by Insulin and Insulin-Like Growth Factors I and II upon Binding to Insulin Receptor Isoform A. Endocrinology 150:8, pages 3594-3602.
Crossref
Pradeep Sathyanarayana, Estelle Houde, Deborah Marshall, Amy Volk, Dorie Makropoulos, Christine Emerson, Anamika Pradeep, Peter J. Bugelski & Don M. Wojchowski. (2009) CNTO 530 functions as a potent EPO mimetic via unique sustained effects on bone marrow proerythroblast pools. Blood 113:20, pages 4955-4962.
Crossref
Y. Hayabuchi, G.B. Willars, N.B. Standen & N.W. Davies. (2008) Insulin-like growth factor-I inhibits rat arterial KATP channels through pI 3-kinase. Biochemical and Biophysical Research Communications 374:4, pages 742-746.
Crossref
Ellen WeisbergLolita BanerjiRenee D. WrightRosemary BarrettArghya RayDaisy MorenoLaurence CatleyJingrui JiangElizabeth Hall-MeyersMaira Sauveur-MichelRichard Stone, Ilene GalinskyEdward Fox, Andrew L. KungJames D. Griffin. (2008) Potentiation of antileukemic therapies by the dual PI3K/PDK-1 inhibitor, BAG956: effects on BCR-ABL– and mutant FLT3-expressing cells. Blood 111:7, pages 3723-3734.
Crossref
L S Steelman, S L Abrams, J Whelan, F E Bertrand, D E Ludwig, J Bäsecke, M Libra, F Stivala, M Milella, A Tafuri, P Lunghi, A Bonati, A M Martelli & J A McCubrey. (2008) Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia. Leukemia 22:4, pages 686-707.
Crossref
Vittorio Fattori, Shin-ichi Abe, Kumiko Kobayashi, Lucio G. Costa & Ryozo Tsuji. (2008) Effects of postnatal ethanol exposure on neurotrophic factors and signal transduction pathways in rat brain. Journal of Applied Toxicology 28:3, pages 370-376.
Crossref
Alex M. Wolf, Anna I. Lyuksyutova, Ali G. Fenstermaker, Beth Shafer, Charles G. Lo & Yimin Zou. (2008) Phosphatidylinositol-3-Kinase–Atypical Protein Kinase C Signaling Is Required for Wnt Attraction and Anterior–Posterior Axon Guidance. The Journal of Neuroscience 28:13, pages 3456-3467.
Crossref
James A. McCubrey, Melissa L. Sokolosky, Brian D. Lehmann, Jackson R. Taylor, Patrick M. Navolanic, William H. Chappell, Stephen L. Abrams, Kristin M. Stadelman, Ellis W.T. Wong, Negin Misaghian, Stefan Horn, Jörg Bäsecke, Massimo Libra, Franca Stivala, Giovanni Ligresti, Agostino Tafuri, Michele Milella, Marek Zarzycki, Andrzej Dzugaj, Francesca Chiarini, Camilla Evangelisti, Alberto M. Martelli, David M. Terrian, Richard A. Franklin & Linda S. Steelman. (2008) Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy. Advances in Enzyme Regulation 48:1, pages 113-135.
Crossref
T.C. Sacktor. 2008. Learning and Memory: A Comprehensive Reference. Learning and Memory: A Comprehensive Reference 449 467 .
James A. McCubrey, Richard A. Franklin, Fred E. Bertrand, Jackson R. Taylor, William H. Chappell, Melissa L. Midgett, Ellis W. T. Wong, Stephen L. Abrams, Kristin M. Stadelman, Negin Misaghian, Dale L. Ludwig, Jorg Basecke, Massimo Libra, Franca Stivala, Michele Milella, Agostino Tafuri, Alberto M. Martelli, Paolo Lungi, Antonio Bonati, David M. Terrian, Brian D. Lehmann & Linda S. Steelman. 2008. Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy. Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy 81 114 .
Rupangi C. Vasavada, Lin Wang, Yuichi Fujinaka, Karen K. Takane, Taylor C. Rosa, Jose M.D. Mellado-Gil, Peter A. Friedman & Adolfo Garcia-Ocaña. (2007) Protein Kinase C-ζ Activation Markedly Enhances β-Cell Proliferation. Diabetes 56:11, pages 2732-2743.
Crossref
Jonathan Chi-Hang Li & Ronghao Li. (2007) RAV12 Accelerates the Desensitization of Akt/PKB Pathway of Insulin-like Growth Factor I Receptor Signaling in COLO205. Cancer Research 67:18, pages 8856-8864.
Crossref
Hyun-Ji Oh, Jason S. Lee, Dae-Kyu Song, Dong-Hoon Shin, Byeong-Churl Jang, Seong-Il Suh, Jong-Wook Park, Min-Ho Suh & Won-Ki Baek. (2007) d-Glucosamine inhibits proliferation of human cancer cells through inhibition of p70S6K. Biochemical and Biophysical Research Communications 360:4, pages 840-845.
Crossref
Senthil Ranganathan, Yimin Wang, Francis G. Kern, Zhican Qu & Rongbao Li. (2007) Activation loop phosphorylation-independent kinase activity of human protein kinase C ζ. Proteins: Structure, Function, and Bioinformatics 67:3, pages 709-719.
Crossref
Philippe P. Roux, David Shahbazian, Hieu Vu, Marina K. Holz, Michael S. Cohen, Jack Taunton, Nahum Sonenberg & John Blenis. (2007) RAS/ERK Signaling Promotes Site-specific Ribosomal Protein S6 Phosphorylation via RSK and Stimulates Cap-dependent Translation. Journal of Biological Chemistry 282:19, pages 14056-14064.
Crossref
Toshie Kanayasu-Toyoda, Takayoshi Suzuki, Tadashi Oshizawa, Eriko Uchida, Takao Hayakawa & Teruhide Yamaguchi. (2007) Granulocyte colony-stimulating factor promotes the translocation of protein kinase Cι in neutrophilic differentiation cells. Journal of Cellular Physiology 211:1, pages 189-196.
Crossref
Liliana Schaefer, Wasiliki Tsalastra, Andrea Babelova, Martina Baliova, Jens Minnerup, Lydia Sorokin, Hermann-Josef Gröne, Dieter P. Reinhardt, Josef Pfeilschifter, Renato V. Iozzo & Roland M. Schaefer. (2007) Decorin-Mediated Regulation of Fibrillin-1 in the Kidney Involves the Insulin-Like Growth Factor-I Receptor and Mammalian Target of Rapamycin. The American Journal of Pathology 170:1, pages 301-315.
Crossref
Sang K. Kim & Raymond F. Novak. (2007) The role of intracellular signaling in insulin-mediated regulation of drug metabolizing enzyme gene and protein expression. Pharmacology & Therapeutics 113:1, pages 88-120.
Crossref
James A. McCubrey, Linda S. Steelman, Richard A. Franklin, Steven L. Abrams, William H. Chappell, Ellis W.T. Wong, Brian D. Lehmann, David M. Terrian, Jorg Basecke, Franca Stivala, Massimo Libra, Camilla Evangelisti & Alberto M. Martelli. (2007) Targeting the RAF/MEK/ERK, PI3K/AKT and P53 pathways in hematopoietic drug resistance. Advances in Enzyme Regulation 47:1, pages 64-103.
Crossref
Takahiro Inoue, Toru Yoshida, Yosuke Shimizu, Takashi Kobayashi, Toshinari Yamasaki, Yoshinobu Toda, Takehiko Segawa, Toshiyuki Kamoto, Eijiro Nakamura & Osamu Ogawa. (2006) Requirement of Androgen-Dependent Activation of Protein Kinase Cζ for Androgen-Dependent Cell Proliferation in LNCaP Cells and Its Roles in Transition to Androgen-Independent Cells. Molecular Endocrinology 20:12, pages 3053-3069.
Crossref
Reinoud Gosens, Johan Zaagsma, Herman Meurs & Andrew J Halayko. (2006) Muscarinic receptor signaling in the pathophysiology of asthma and COPD. Respiratory Research 7:1.
Crossref
Xiao-Qi Wang, Ping Sun, Linda Go, Viola Koti, Margarita Fliman & Amy S. Paller. (2006) Ganglioside GM3 Promotes Carcinoma Cell Proliferation via Urokinase Plasminogen Activator-Induced Extracellular Signal-Regulated Kinase-Independent p70S6 Kinase Signaling. Journal of Investigative Dermatology 126:12, pages 2687-2696.
Crossref
Maÿlis Trucy, Christiane Barbat, Alain Fischer & Fabienne Mazerolles. (2006) CD4 ligation induces activation of protein kinase C zeta and phosphoinositide-dependent-protein kinase-1, two kinases required for down-regulation of LFA-1-mediated adhesion. Cellular Immunology 244:1, pages 33-42.
Crossref
M Manuvakhova, J V Thottassery, S Hays, Z Qu, S S Rentz, L Westbrook & F G Kern. (2006) Expression of the SNT-1/FRS2 phosphotyrosine binding domain inhibits activation of MAP kinase and PI3-kinase pathways and antiestrogen resistant growth induced by FGF-1 in human breast carcinoma cells. Oncogene 25:44, pages 6003-6014.
Crossref
Reba Mustafi, Sonia Cerda, Anusara Chumsangsri, Alessandro Fichera & Marc Bissonnette. (2006) Protein Kinase-ζ Inhibits Collagen I–Dependent and Anchorage-Independent Growth and Enhances Apoptosis of Human Caco-2 Cells. Molecular Cancer Research 4:9, pages 683-694.
Crossref
Edward W. Arvisais, Angela Romanelli, Xiaoying Hou & John S. Davis. (2006) AKT-independent Phosphorylation of TSC2 and Activation of mTOR and Ribosomal Protein S6 Kinase Signaling by Prostaglandin F2α. Journal of Biological Chemistry 281:37, pages 26904-26913.
Crossref
Supantitra Chanprasert, Amy E. Geddis, Charlene Barroga, Norma E. Fox & Kenneth Kaushansky. (2006) Thrombopoietin (TPO) induces c-myc expression through a PI3K- and MAPK-dependent pathway that is not mediated by Akt, PKCζ or mTOR in TPO-dependent cell lines and primary megakaryocytes. Cellular Signalling 18:8, pages 1212-1218.
Crossref
Sophie Tesseraud, Mourad Abbas, Sophie Duchene, Karine Bigot, Pascal Vaudin & Joëlle Dupont. (2007) Mechanisms involved in the nutritional regulation of mRNA translation: features of the avian model. Nutrition Research Reviews 19:1, pages 104-116.
Crossref
Paul Smolen, Douglas A. Baxter & John H. Byrne. (2006) A Model of the Roles of Essential Kinases in the Induction and Expression of Late Long-Term Potentiation. Biophysical Journal 90:8, pages 2760-2775.
Crossref
Reinoud Gosens, Mechteld M. Grootte Bromhaar, Harm Maarsingh, Anita ten Damme, Herman Meurs, Johan Zaagsma & S. Adriaan Nelemans. (2006) Bradykinin augments EGF-induced airway smooth muscle proliferation by activation of conventional protein kinase C isoenzymes. European Journal of Pharmacology 535:1-3, pages 253-262.
Crossref
JOHN K. BUOLAMWINI. 2006. Novel Anticancer Agents. Novel Anticancer Agents 1 35 .
S. L. Longnus, C. Ségalen, J. Giudicelli, M. P. Sajan, R. V. Farese & E. Van Obberghen. (2005) Insulin signalling downstream of protein kinase B is potentiated by 5′AMP-activated protein kinase in rat hearts in vivo. Diabetologia 48:12, pages 2591-2601.
Crossref
Marina K. Holz, Bryan A. Ballif, Steven P. Gygi & John Blenis. (2005) mTOR and S6K1 Mediate Assembly of the Translation Preinitiation Complex through Dynamic Protein Interchange and Ordered Phosphorylation Events. Cell 123:4, pages 569-580.
Crossref
Simrit ParmarJessica SmithAntonella SassanoShahab UddinEfstratios KatsoulidisBeata MajchrzakSuman KambhampatiElizabeth A. EklundMartin S. TallmanEleanor N. FishLeonidas C. Platanias. (2005) Differential regulation of the p70 S6 kinase pathway by interferon α (IFNα) and imatinib mesylate (STI571) in chronic myelogenous leukemia cells. Blood 106:7, pages 2436-2443.
Crossref
Jin Park, Seung H. Kim, Daeho Cho & Tae S. Kim. (2005) Formononetin, a phyto-oestrogen, and its metabolites up-regulate interleukin-4 production in activated T cells via increased AP-1 DNA binding activity. Immunology 116:1, pages 71-81.
Crossref
Marina K. Holz & John Blenis. (2005) Identification of S6 Kinase 1 as a Novel Mammalian Target of Rapamycin (mTOR)-phosphorylating Kinase. Journal of Biological Chemistry 280:28, pages 26089-26093.
Crossref
Miri Stolovich, Tal Lerer, Yoav Bolkier, Hannah Cohen & Oded Meyuhas. (2005) Lithium Can Relieve Translational Repression of TOP mRNAs Elicited by Various Blocks along the Cell Cycle in a Glycogen Synthase Kinase-3- and S6-Kinase-independent Manner. Journal of Biological Chemistry 280:7, pages 5336-5342.
Crossref
Evgenia V. Gerasimovskaya, Doug A. Tucker, Mary Weiser-Evans, Janet M. Wenzlau, Dwight J. Klemm, Mark Banks & Kurt R. Stenmark. (2005) Extracellular ATP-induced Proliferation of Adventitial Fibroblasts Requires Phosphoinositide 3-Kinase, Akt, Mammalian Target of Rapamycin, and p70 S6 Kinase Signaling Pathways. Journal of Biological Chemistry 280:3, pages 1838-1848.
Crossref
Robert D. Blitzer, Ravi Iyengar & Emmanuel M. Landau. (2005) Postsynaptic signaling networks: Cellular cogwheels underlying long-term plasticity. Biological Psychiatry 57:2, pages 113-119.
Crossref
Bernard Masri, Natacha Morin, Marion Cornu, Bernard Knibiehler & Yves Audigier. (2004) Apelin (65‐77) activates p70 S6 kinase and is mitogenic for umbilical endothelial cells. The FASEB Journal 18:15, pages 1909-1911.
Crossref
Thomas L. Smith & Miriam C. Eaton. (2004) Continuous ethanol exposure inhibits agonist-stimulated phosphorylation of p70S6 kinase and ribosomal S6 protein in cultured rat astrocytes. Molecular Brain Research 131:1-2, pages 145-148.
Crossref
Philippe P. Roux, Bryan A. Ballif, Rana Anjum, Steven P. Gygi & John Blenis. (2004) Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. Proceedings of the National Academy of Sciences 101:37, pages 13489-13494.
Crossref
Celeste J. Richardson, Mark Bröenstrup, Diane C. Fingar, Kristina Jülich, Bryan A. Ballif, Steven Gygi & John Blenis. (2004) SKAR Is a Specific Target of S6 Kinase 1 in Cell Growth Control. Current Biology 14:17, pages 1540-1549.
Crossref
O. Jameel Shah & Tony Hunter. (2004) Critical Role of T-Loop and H-Motif Phosphorylation in the Regulation of S6 Kinase 1 by the Tuberous Sclerosis Complex. Journal of Biological Chemistry 279:20, pages 20816-20823.
Crossref
Mathew L. Coleman, Christopher J. Marshall & Michael F. Olson. (2004) RAS and RHO GTPases in G1-phase cell-cycle regulation. Nature Reviews Molecular Cell Biology 5:5, pages 355-366.
Crossref
Diane C Fingar & John Blenis. (2004) Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 23:18, pages 3151-3171.
Crossref
Paramita M. Ghosh, Roble Bedolla, Charles A. Thomas & Jeffrey I. Kreisberg. (2004) Role of protein kinase C in arginine vasopressin-stimulated ERK and p70S6 kinase phosphorylation. Journal of Cellular Biochemistry 91:6, pages 1109-1129.
Crossref
Celeste J Richardson, Stefanie S Schalm & John Blenis. (2004) PI3-kinase and TOR: PIKTORing cell growth. Seminars in Cell & Developmental Biology 15:2, pages 147-159.
Crossref
Jack L Arbiser. (2004) Molecular regulation of angiogenesis and tumorigenesis by signal transduction pathways: evidence of predictable and reproducible patterns of synergy in diverse neoplasms. Seminars in Cancer Biology 14:2, pages 81-91.
Crossref
Xiaohua Wu, Chad E.N. Reiter, David A. Antonetti, Scot R. Kimball, Leonard S. Jefferson & Thomas W. Gardner. (2004) Insulin Promotes Rat Retinal Neuronal Cell Survival in a p70S6K-dependent Manner. Journal of Biological Chemistry 279:10, pages 9167-9175.
Crossref
Fatima Lekmine, Shahab Uddin, Antonella Sassano, Simrit Parmar, Saskia M. Brachmann, Beata Majchrzak, Nahum Sonenberg, Nissim Hay, Eleanor N. Fish & Leonidas C. Platanias. (2003) Activation of the p70 S6 Kinase and Phosphorylation of the 4E-BP1 Repressor of mRNA Translation by Type I Interferons. Journal of Biological Chemistry 278:30, pages 27772-27780.
Crossref
Rastislav Tamaskovic, Samuel J. Bichsel, Hélène Rogniaux, Mario R. Stegert & Brian A. Hemmings. (2003) Mechanism of Ca2+-mediated Regulation of NDR Protein Kinase through Autophosphorylation and Phosphorylation by an Upstream Kinase. Journal of Biological Chemistry 278:9, pages 6710-6718.
Crossref
Xiao-Feng Le, Walter N Hittelman, Jiaxin Liu, Amanda McWatters, Chun Li, Gordon B Mills & Robert C BastJrJr. (2003) Paclitaxel induces inactivation of p70 S6 kinase and phosphorylation of Thr421 and Ser424 via multiple signaling pathways in mitosis. Oncogene 22:4, pages 484-497.
Crossref
Alexander Sorisky, Annemarie Gagnon, Andrea Bell & Darine El-Chaar. 2003. Atherosclerosis, Hypertension and Diabetes. Atherosclerosis, Hypertension and Diabetes 119 127 .
Lucio G. Costa & Marina Guizzetti. (2002) Inhibition of Muscarinic Receptor-Induced Proliferation of Astroglial Cells by Ethanol: Mechanisms and Implications for the Fetal Alcohol Syndrome. NeuroToxicology 23:6, pages 685-691.
Crossref
Constantin Makris, Laure Voisin, Edith Giasson, Christopher Tudan, David R Kaplan & Sylvain Meloche. (2002) The Rb-family protein p107 inhibits translation by a PDK1-dependent mechanism. Oncogene 21:51, pages 7891-7896.
Crossref
Angela Romanelli, Valley C. Dreisbach & John Blenis. (2002) Characterization of Phosphatidylinositol 3-Kinase-dependent Phosphorylation of the Hydrophobic Motif Site Thr389 in p70 S6 Kinase 1. Journal of Biological Chemistry 277:43, pages 40281-40289.
Crossref
Ann-Kristin Ruud Larsen, Michael T.N. Møller, Henrietta Blankson, Hamid R. Samari, Lise Holden & Per O. Seglen. (2002) Naringin-sensitive Phosphorylation of Plectin, a Cytoskeletal Cross-linking Protein, in Isolated Rat Hepatocytes. Journal of Biological Chemistry 277:38, pages 34826-34835.
Crossref
Toshie Kanayasu-Toyoda, Teruhide Yamaguchi, Tadashi Oshizawa, Mieko Kogi, Eriko Uchida & Takao Hayakawa. (2002) Role of the p70 S6 kinase cascade in neutrophilic differentiation and proliferation of HL-60 cells—a study of transferrin receptor-positive and -negative cells obtained from dimethyl sulfoxide- or retinoic acid-treated HL-60 cells. Archives of Biochemistry and Biophysics 405:1, pages 21-31.
Crossref
Elena A. Goncharova, Dmitry A. Goncharov, Andrew Eszterhas, Deborah S. Hunter, Marilyn K. Glassberg, Raymond S. Yeung, Cheryl L. Walker, Daniel Noonan, David J. Kwiatkowski, Margaret M. Chou, Reynold A. PanettieriJr.Jr. & Vera P. Krymskaya. (2002) Tuberin Regulates p70 S6 Kinase Activation and Ribosomal Protein S6 Phosphorylation. Journal of Biological Chemistry 277:34, pages 30958-30967.
Crossref
Marina Guizzetti & Lucio G. Costa. (2002) Effect of ethanol on protein kinase Cζ and p70S6 kinase activation by carbachol: a possible mechanism for ethanol-induced inhibition of glial cell proliferation. Journal of Neurochemistry 82:1, pages 38-46.
Crossref
Brendan D Manning, Andrew R Tee, M.Nicole Logsdon, John Blenis & Lewis C Cantley. (2002) Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway. Molecular Cell 10:1, pages 151-162.
Crossref
Tetsuya YamadaHideki KatagiriTomoichiro AsanoMasatoshi TsuruKouichi InukaiHiraku OnoTatsuhiko Kodama, Masatoshi KikuchiYoshitomo Oka. (2002) Role of PDK1 in insulin-signaling pathway for glucose metabolism in 3T3-L1 adipocytes. American Journal of Physiology-Endocrinology and Metabolism 282:6, pages E1385-E1394.
Crossref
Masao Saitoh, Nicholas Pullen, Paul Brennan, Doreen Cantrell, Patrick B. Dennis & George Thomas. (2002) Regulation of an Activated S6 Kinase 1 Variant Reveals a Novel Mammalian Target of Rapamycin Phosphorylation Site. Journal of Biological Chemistry 277:22, pages 20104-20112.
Crossref
Eric A. Drier, Marcela K. Tello, Maureen Cowan, Priscilla Wu, Nancy Blace, Todd Charlton Sacktor & Jerry C.P. Yin. (2002) Memory enhancement and formation by atypical PKM activity in Drosophila melanogaster. Nature Neuroscience 5:4, pages 316-324.
Crossref
Jonathan M. Ellery & Peter J. Nicholls. (2002) Alternate signalling pathways from the interleukin-2 receptor. Cytokine & Growth Factor Reviews 13:1, pages 27-40.
Crossref
Ana González-Garcı́a, Elia Garrido, Carmen Hernández, Beatriz Alvarez, Concepción Jiménez, Doreen A. Cantrell, Nicholas Pullen & Ana C. Carrera. (2002) A New Role for the p85-Phosphatidylinositol 3-Kinase Regulatory Subunit Linking FRAP to p70 S6 Kinase Activation. Journal of Biological Chemistry 277:2, pages 1500-1508.
Crossref
Kathleen A. Martin & John Blenis. 2002. 1 39 .
Bastien D. Gomperts, Ijsbrand M. Kramer & Peter E.R. Tatham. 2002. Signal Transduction. Signal Transduction 299 313 .
Masaaki Nomura, Akira Kaji, Zhiwei He, Wei-Ya Ma, Ken-ichi Miyamoto, Chung S. Yang & Zigang Dong. (2001) Inhibitory Mechanisms of Tea Polyphenols on the Ultraviolet B-activated Phosphatidylinositol 3-Kinase-dependent Pathway. Journal of Biological Chemistry 276:49, pages 46624-46631.
Crossref
Ponlapat Rojnuckarin, Yoshitaka Miyakawa, Norma E. Fox, Jessie Deou, Guenter Daum & Kenneth Kaushansky. (2001) The Roles of Phosphatidylinositol 3-Kinase and Protein Kinase Cζ for Thrombopoietin-induced Mitogen-activated Protein Kinase Activation in Primary Murine Megakaryocytes. Journal of Biological Chemistry 276:44, pages 41014-41022.
Crossref
Jongsun Park, Michelle M. Hill, Daniel Hess, Derek P. Brazil, Jan Hofsteenge & Brian A. Hemmings. (2001) Identification of Tyrosine Phosphorylation Sites on 3-Phosphoinositide-dependent Protein Kinase-1 and Their Role in Regulating Kinase Activity. Journal of Biological Chemistry 276:40, pages 37459-37471.
Crossref
Francis S. Willard, Leise A. Berven & Michael F. Crouch. (2001) Lysophosphatidic Acid Activates the 70-kDa S6 Kinase via the Lipoxygenase Pathway. Biochemical and Biophysical Research Communications 287:3, pages 607-613.
Crossref
Mi-Sun Kim, Woon-Ki Lim, Jin-Geun Cha, Nyeon-Hyoung An, Su-Jin Yoo, Jae-Hwang Park, Hyung-Min Kim & Young-Mi Lee. (2001) The activation of PI 3-K and PKC ζ in PMA-induced differentiation of HL-60 cells. Cancer Letters 171:1, pages 79-85.
Crossref
Gudiseva Chandrasekher, Azucena H Kakazu & Haydee E.P Bazan. (2001) HGF- and KGF-induced Activation of PI-3K/p70 S6 Kinase Pathway in Corneal Epithelial Cells: its Relevance in Wound Healing. Experimental Eye Research 73:2, pages 191-202.
Crossref
Yiguo Zhang, Ziming Dong, Masaaki Nomura, Shuping Zhong, Nanyue Chen, Ann M. Bode & Zigang Dong. (2001) Signal Transduction Pathways Involved in Phosphorylation and Activation of p70S6K Following Exposure to UVA Irradiation. Journal of Biological Chemistry 276:24, pages 20913-20923.
Crossref
Volkan Dayanir, Rosana D. Meyer, Kameran Lashkari & Nader Rahimi. (2001) Identification of Tyrosine Residues in Vascular Endothelial Growth Factor Receptor-2/FLK-1 Involved in Activation of Phosphatidylinositol 3-Kinase and Cell Proliferation. Journal of Biological Chemistry 276:21, pages 17686-17692.
Crossref
Palle G. Laustsen, William S. Lane, Vann Bennett & Gustav E. Lienhard. (2001) Association of protein kinase Cλ with adducin in 3T3-L1 adipocytes. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1539:1-2, pages 163-172.
Crossref
Bryan A. Ballif, Akiko Shimamura, Eunice Pae & John Blenis. (2001) Disruption of 3-Phosphoinositide-dependent Kinase 1 (PDK1) Signaling by the Anti-tumorigenic and Anti-proliferative AgentN-α-tosyl-l-phenylalanyl Chloromethyl Ketone. Journal of Biological Chemistry 276:15, pages 12466-12475.
Crossref
Yan-Fang Liu, Keren Paz, Avia Herschkovitz, Addy Alt, Tamar Tennenbaum, Sanford R. Sampson, Motoi Ohba, Toshio Kuroki, Derek LeRoith & Yehiel Zick. (2001) Insulin Stimulates PKCζ-mediated Phosphorylation of Insulin Receptor Substrate-1 (IRS-1). Journal of Biological Chemistry 276:17, pages 14459-14465.
Crossref
Lihua Zhang, Shi-Lan Wu & Charles S. Rubin. (2001) A Novel Adapter Protein Employs a Phosphotyrosine Binding Domain and Exceptionally Basic N-terminal Domains to Capture and Localize an Atypical Protein Kinase C. Journal of Biological Chemistry 276:13, pages 10463-10475.
Crossref
Kathleen A. Martin, Stefanie S. Schalm, Celeste Richardson, Angela Romanelli, Kristen L. Keon & John Blenis. (2001) Regulation of Ribosomal S6 Kinase 2 by Effectors of the Phosphoinositide 3-Kinase Pathway. Journal of Biological Chemistry 276:11, pages 7884-7891.
Crossref
Lingamanaidu V. Ravichandran, Diana L. Esposito, Judy Chen & Michael J. Quon. (2001) Protein Kinase C-ζ Phosphorylates Insulin Receptor Substrate-1 and Impairs Its Ability to Activate Phosphatidylinositol 3-Kinase in Response to Insulin. Journal of Biological Chemistry 276:5, pages 3543-3549.
Crossref
Soumitro Pal, Kaustubh Datta, Roya Khosravi-Far & Debabrata Mukhopadhyay. (2001) Role of Protein Kinase Cζ in Ras-mediated Transcriptional Activation of Vascular Permeability Factor/Vascular Endothelial Growth Factor Expression. Journal of Biological Chemistry 276:4, pages 2395-2403.
Crossref
Estelle Sontag. (2001) Protein phosphatase 2A: the Trojan Horse of cellular signaling. Cellular Signalling 13:1, pages 7-16.
Crossref
Scot R. Kimball. 2001. Signaling Pathways for Translation. Signaling Pathways for Translation 155 184 .
Joseph Avruch, Christopher Belham, Qing-Peng Weng, Kenta Hara & Kazuyoshi Yonezawa. 2001. Signaling Pathways for Translation. Signaling Pathways for Translation 115 154 .
Mariko Kashiwagi, Motoi Ohba, Hiroyuki Watanabe, Keiko Ishino, Kohji Kasahara, Yutaka Sanai, Yoichi Taya & Toshio Kuroki. (2000) PKCη associates with cyclin E/cdk2/p21 complex, phosphorylates p21 and inhibits cdk2 kinase in keratinocytes. Oncogene 19:54, pages 6334-6341.
Crossref
Oded Meyuhas. (2000) Synthesis of the translational apparatus is regulated at the translational level. European Journal of Biochemistry 267:21, pages 6321-6330.
Crossref
Marina Guizzetti & Lucio G Costa. (2000) Possible role of protein kinase C ζ in muscarinic receptor-induced proliferation of astrocytoma cells. Biochemical Pharmacology 60:10, pages 1457-1466.
Crossref
O. Jameel Shah, Joshua C. Anthony, Scot R. Kimball & Leonard S. Jefferson. (2000) 4E-BP1 and S6K1: translational integration sites for nutritional and hormonal information in muscle. American Journal of Physiology-Endocrinology and Metabolism 279:4, pages E715-E729.
Crossref
MELEIK A. HEBERT & JAMES P. O'CALLAGHAN. (2000) Protein Phosphorylation Cascades Associated with Methamphetamine-induced Glial Activation. Annals of the New York Academy of Sciences 914:1, pages 238-262.
Crossref
Ko Kotani, Wataru Ogawa, Mitsuru Hashiramoto, Tetsuo Onishi, Shigeo Ohno & Masato Kasuga. (2000) Inhibition of Insulin-induced Glucose Uptake by Atypical Protein Kinase C Isotype-specific Interacting Protein in 3T3-L1 Adipocytes. Journal of Biological Chemistry 275:34, pages 26390-26395.
Crossref
Leise A Berven & Michael F Crouch. (2000) Cellular function of p70 S6K : A role in regulating cell motility . Immunology & Cell Biology 78:4, pages 447-451.
Crossref
Anudharan Balendran, Ricardo M. Biondi, Peter C.F. Cheung, Antonio Casamayor, Maria Deak & Dario R. Alessi. (2000) A 3-Phosphoinositide-dependent Protein Kinase-1 (PDK1) Docking Site Is Required for the Phosphorylation of Protein Kinase Cζ (PKCζ) and PKC-related Kinase 2 by PDK1. Journal of Biological Chemistry 275:27, pages 20806-20813.
Crossref
Makoto Kanzaki, Robert T. Watson, Nikolai O. Artemyev & Jeffrey E. Pessin. (2000) The Trimeric GTP-binding Protein (Gq/G11) α Subunit Is Required for Insulin-stimulated GLUT4 Translocation in 3T3L1 Adipocytes. Journal of Biological Chemistry 275:10, pages 7167-7175.
Crossref
Siniša Volarević & George Thomas. 2000. 101 127 .
Anudharan Balendran, Richard Currie, Christopher G. Armstrong, Joeseph Avruch & Dario R. Alessi. (1999) Evidence That 3-Phosphoinositide-dependent Protein Kinase-1 Mediates Phosphorylation of p70 S6 Kinase in Vivoat Thr-412 as well as Thr-252. Journal of Biological Chemistry 274:52, pages 37400-37406.
Crossref
Gyu-Un Bae, Dong-Wan Seo, Hyoung-Keun Kwon, Hoi Young Lee, Sungyoul Hong, Zee-Won Lee, Kwon-Soo Ha, Hyang-Woo Lee & Jeung-Whan Han. (1999) Hydrogen Peroxide Activates p70S6k Signaling Pathway. Journal of Biological Chemistry 274:46, pages 32596-32602.
Crossref
Almut Dufner & George Thomas. (1999) Ribosomal S6 Kinase Signaling and the Control of Translation. Experimental Cell Research 253:1, pages 100-109.
Crossref
Kay K Lee-Fruman, Calvin J Kuo, John Lippincott, Naohiro Terada & John Blenis. (1999) Characterization of S6K2, a novel kinase homologous to S6K1. Oncogene 18:36, pages 5108-5114.
Crossref
Stephanie A. Richards, Joyce Fu, Angela Romanelli, Akiko Shimamura & John Blenis. (1999) Ribosomal S6 kinase 1 (RSK1) activation requires signals dependent on and independent of the MAP kinase ERK. Current Biology 9:15, pages 810-S1.
Crossref
Randall T. Peterson & Stuart L. Schreiber. (1999) Kinase phosphorylation: Keeping it all in the family. Current Biology 9:14, pages R521-R524.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.