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Transcriptional Regulation

Cumulative Effect of Phosphorylation of pRB on Regulation of E2F Activity

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Pages 3246-3256 | Received 26 Oct 1998, Accepted 03 Feb 1999, Published online: 28 Mar 2023

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Nathan Wlodarchak & Yongna Xing. (2016) PP2A as a master regulator of the cell cycle. Critical Reviews in Biochemistry and Molecular Biology 51:3, pages 162-184.
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Kevin Y. Kim, Don-Hong Wang, Mel Campbell, Steve B. Huerta, Bogdan Shevchenko, Chie Izumiya & Yoshihiro Izumiya. (2015) PRMT4-Mediated Arginine Methylation Negatively Regulates Retinoblastoma Tumor Suppressor Protein and Promotes E2F-1 Dissociation. Molecular and Cellular Biology 35:1, pages 238-248.
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C. Ramakrishnan, V. Subramanian, K. Balamurugan & D. Velmurugan. (2013) Molecular dynamics simulations of retinoblastoma protein. Journal of Biomolecular Structure and Dynamics 31:11, pages 1277-1292.
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Ludger Hauck, Rudolf G. Kaba, Martin Lipp, Rainer Dietz & Rüdiger von Harsdorf. (2002) Regulation of E2F1-Dependent Gene Transcription and Apoptosis by the ETS-Related Transcription Factor GABPγ1. Molecular and Cellular Biology 22:7, pages 2147-2158.
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Vivette D. Brown & Brenda L. Gallie. (2002) The B-Domain Lysine Patch of pRB Is Required for Binding to Large T Antigen and Release of E2F by Phosphorylation. Molecular and Cellular Biology 22:5, pages 1390-1401.
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Sergei A. Ezhevsky, Alan Ho, Michelle Becker-Hapak, Penny K. Davis & Steven F. Dowdy. (2001) Differential Regulation of Retinoblastoma Tumor Suppressor Protein by G1 Cyclin-Dependent Kinase Complexes In Vivo. Molecular and Cellular Biology 21:14, pages 4773-4784.
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PATRICIA M. FLATT & JENNIFER A. PIETENPOL. (2000) MECHANISMS OF CELL-CYCLE CHECKPOINTS: AT THE CROSSROADS OF CARCINOGENESIS AND DRUG DISCOVERY*. Drug Metabolism Reviews 32:3-4, pages 283-305.
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George Jour, Ashley Gullet, Mingdong Liu & Benjamin L Hoch. (2015) Prognostic relevance of Fédération Nationale des Centres de Lutte Contre le Cancer grade and MDM2 amplification levels in dedifferentiated liposarcoma: a study of 50 cases. Modern Pathology 28:1, pages 37-47.
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Suvi Lokka, Andreas H Scheel, Sebastian Dango, Katja Schmitz, Rudolf Hesterberg, Josef Rüschoff & Hans-Ulrich Schildhaus. (2014) Challenging dedifferentiated liposarcoma identified by MDM2-amplification, a report of two cases. BMC Clinical Pathology 14:1.
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Jason R. Burke, Tyler J. Liban, Tamara Restrepo, Hsiau-Wei Lee & Seth M. Rubin. (2014) Multiple Mechanisms for E2F Binding Inhibition by Phosphorylation of the Retinoblastoma Protein C-Terminal Domain. Journal of Molecular Biology 426:1, pages 245-255.
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Frederick A. Dick & Seth M. Rubin. (2013) Molecular mechanisms underlying RB protein function. Nature Reviews Molecular Cell Biology 14:5, pages 297-306.
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Seth M. Rubin. (2013) Deciphering the retinoblastoma protein phosphorylation code. Trends in Biochemical Sciences 38:1, pages 12-19.
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Andreas M.F. Heilmann & Nicholas J. Dyson. (2012) Phosphorylation puts the pRb tumor suppressor into shape: Figure 1.. Genes & Development 26:11, pages 1128-1130.
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Jason R. Burke, Greg L. Hura & Seth M. Rubin. (2012) Structures of inactive retinoblastoma protein reveal multiple mechanisms for cell cycle control. Genes & Development 26:11, pages 1156-1166.
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Weibo Zhang, Betsy Vazquez, Viktoria Andreeva, Daisy Spear, Elizabeth Kong, Philip W. Hinds & Pamela C. Yelick. (2012) Discrete phosphorylated retinoblastoma protein isoform expression in mouse tooth development. Journal of Molecular Histology 43:3, pages 281-288.
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Justyna Teresa Polit, Andrzej Kaźmierczak & Aurelia Walczak-Drzewiecka. (2011) Cell cycle-dependent phosphorylation of pRb-like protein in root meristem cells of Vicia faba. Protoplasma 249:1, pages 131-137.
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Justin P. Kumar. (2011) My what big eyes you have: How the Drosophila retina grows. Developmental Neurobiology 71:12, pages 1133-1152.
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Jeremy G. Stone, Sandra L. Siedlak, Massimo Tabaton, Asao Hirano, Rudy J. Castellani, Corrado Santocanale, George Perry, Mark A. Smith, Xiongwei Zhu & Hyoung-gon Lee. (2011) The Cell Cycle Regulator Phosphorylated Retinoblastoma Protein Is Associated With Tau Pathology in Several Tauopathies. Journal of Neuropathology & Experimental Neurology 70:7, pages 578-587.
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Matthew J. Cecchini & Frederick A. Dick. (2011) The biochemical basis of CDK phosphorylation-independent regulation of E2F1 by the retinoblastoma protein. Biochemical Journal 434:2, pages 297-308.
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R B Delston, K A Matatall, Y Sun, M D Onken & J W Harbour. (2010) p38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb–Hdm2 interaction and apoptosis. Oncogene 30:5, pages 588-599.
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Randy Suryadinata, Martin Sadowski, Rohan Steel & Boris Sarcevic. (2011) Cyclin-dependent Kinase-mediated Phosphorylation of RBP1 and pRb Promotes Their Dissociation to Mediate Release of the SAP30·mSin3·HDAC Transcriptional Repressor Complex. Journal of Biological Chemistry 286:7, pages 5108-5118.
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Emanuela Tumini, Paolo Plevani, Marco Muzi-Falconi & Federica Marini. (2011) Physical and functional crosstalk between Fanconi anemia core components and the GINS replication complex. DNA Repair 10:2, pages 149-158.
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Meenalakshmi Chinnam & David W. Goodrich. 2011. Cancer and Development. Cancer and Development 129 169 .
Randy Suryadinata, Martin Sadowski & Boris Sarcevic. (2010) Control of cell cycle progression by phosphorylation of cyclin-dependent kinase (CDK) substrates. Bioscience Reports 30:4, pages 243-255.
Crossref
Jason R. Burke, Alison J. Deshong, Jeffrey G. Pelton & Seth M. Rubin. (2010) Phosphorylation-induced Conformational Changes in the Retinoblastoma Protein Inhibit E2F Transactivation Domain Binding. Journal of Biological Chemistry 285:21, pages 16286-16293.
Crossref
B. V. Popov, S. M. Watt, J. M. Rosanov & L. -S. Chang. (2010) A structural pocket mutation of pRb increases its affinity for E2F4, which is coupled with activation of muscle differentiation. Molecular Biology 44:2, pages 287-297.
Crossref
Matthew S. Squires, Ruth E. Feltell, Nicola G. Wallis, E. Jonathan Lewis, Donna-Michelle Smith, David M. Cross, John F. Lyons & Neil T. Thompson. (2009) Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines. Molecular Cancer Therapeutics 8:2, pages 324-332.
Crossref
Michelle V. Wagner, Marcus B. Smolka, Rob A. M. de Bruin, Huilin Zhou, Curt Wittenberg & Steven F. Dowdy. (2009) Whi5 Regulation by Site Specific CDK-Phosphorylation in Saccharomyces cerevisiae. PLoS ONE 4:1, pages e4300.
Crossref
Mark Pilkinton, Raudel Sandoval, Kelly Barrett, Xinyong Tian & Oscar R. Colamonici. (2007) Mip/LIN-9 can inhibit cell proliferation independent of the pocket proteins. Blood Cells, Molecules, and Diseases 39:3, pages 272-277.
Crossref
Tae-Hee Kim, Jessica Goodman, Kathryn V. Anderson & Lee Niswander. (2007) Phactr4 Regulates Neural Tube and Optic Fissure Closure by Controlling PP1-, Rb-, and E2F1-Regulated Cell-Cycle Progression. Developmental Cell 13:1, pages 87-102.
Crossref
B. JoshiS. RastogiM. MorrisL. M. CarastroC. DecookE. SetoS. P. Chellappan. (2006) Differential regulation of human YY1 and caspase 7 promoters by prohibitin through E2F1 and p53 binding sites . Biochemical Journal 401:1, pages 155-166.
Crossref
D W Goodrich. (2006) The retinoblastoma tumor-suppressor gene, the exception that proves the rule. Oncogene 25:38, pages 5233-5243.
Crossref
Alexander Roesch, Bernd Becker, Wulf Schneider-Brachert, Ilja Hagen, Michael Landthaler & Thomas Vogt. (2006) Re-Expression of the Retinoblastoma-Binding Protein 2-Homolog 1 Reveals Tumor-Suppressive Functions in Highly Metastatic Melanoma Cells. Journal of Investigative Dermatology 126:8, pages 1850-1859.
Crossref
D Marot, P Opolon, S Brailly-Tabard, N Elie, V Randrianarison, E Connault, N Foray, J Feunteun & M Perricaudet. (2005) The tumor suppressor activity induced by adenovirus-mediated BRCA1 overexpression is not restricted to breast cancers. Gene Therapy 13:3, pages 235-244.
Crossref
Ruth Halaban. 2006. From Melanocytes to Melanoma. From Melanocytes to Melanoma 223 245 .
Seth M. Rubin, Anne-Laure Gall, Ning Zheng & Nikola P. Pavletich. (2005) Structure of the Rb C-Terminal Domain Bound to E2F1-DP1: A Mechanism for Phosphorylation-Induced E2F Release. Cell 123:6, pages 1093-1106.
Crossref
Ruth Halaban. (2005) Rb/E2F: A two-edged sword in the melanocytic system. Cancer and Metastasis Reviews 24:2, pages 339-356.
Crossref
Yue Wu, Andrea Murányi, Ferenc Erdődi & David J. Hartshorne. (2005) Localization of Myosin Phosphatase Target Subunit and its Mutants. Journal of Muscle Research and Cell Motility 26:2-3, pages 123-134.
Crossref
Jan Brzeziński, Adam Migodziński, Aleksandra Toczek, Józef Tazbir & Marek Dedecjus. (2005) Patterns of Cyclin E, Retinoblastoma Protein, and p21Cip1/WAF1 Immunostaining in the Oncogenesis of Papillary Thyroid Carcinoma. Clinical Cancer Research 11:3, pages 1037-1043.
Crossref
. 2005. Biochemie für Mediziner. Biochemie für Mediziner 417 498 .
Ho-Pi Lin, Samuel K. Kulp, Ping-Hui Tseng, Ya-Ting Yang, Chi-Cheng Yang, Chang-Shi Chen & Ching-Shih Chen. (2004) Growth inhibitory effects of celecoxib in human umbilical vein endothelial cells are mediated through G1 arrest via multiple signaling mechanisms. Molecular Cancer Therapeutics 3:12, pages 1671-1680.
Crossref
M. Julia B.F. Flaminio, Andrew Yen & Douglas F. Antczak. (2004) The proliferation inhibitory proteins p27Kip1 and retinoblastoma are involved in the control of equine lymphocyte proliferation. Veterinary Immunology and Immunopathology 102:4, pages 363-377.
Crossref
Lynn M. Knowles, Fumiko Axelrod, Cecille D. Browne & Jeffrey W. Smith. (2004) A Fatty Acid Synthase Blockade Induces Tumor Cell-cycle Arrest by Down-regulating Skp2. Journal of Biological Chemistry 279:29, pages 30540-30545.
Crossref
Maria N. Garnovskaya, Yurii V. Mukhin, Tamara M. Vlasova, Jasjit S. Grewal, Michael E. Ullian, Baby G. Tholanikunnel & John R. Raymond. (2004) Mitogen-induced Rapid Phosphorylation of Serine 795 of the Retinoblastoma Gene Product in Vascular Smooth Muscle Cells Involves ERK Activation. Journal of Biological Chemistry 279:23, pages 24899-24905.
Crossref
Michael Costanzo, Joy L Nishikawa, Xiaojing Tang, Jonathan S Millman, Oliver Schub, Kevin Breitkreuz, Danielle Dewar, Ivan Rupes, Brenda Andrews & Mike Tyers. (2004) CDK Activity Antagonizes Whi5, an Inhibitor of G1/S Transcription in Yeast. Cell 117:7, pages 899-913.
Crossref
David W. Goodrich. (2003) How the other half lives, the amino-terminal domain of the retinoblastoma tumor suppressor protein. Journal of Cellular Physiology 197:2, pages 169-180.
Crossref
Duanduan Ma, Ping Zhou & J. William Harbour. (2003) Distinct Mechanisms for Regulating the Tumor Suppressor and Antiapoptotic Functions of Rb. Journal of Biological Chemistry 278:21, pages 19358-19366.
Crossref
Faten Anwar. (2003) The Phenotype of Hurthle and Warthin-like Papillary Thyroid Carcinomas Is Distinct From Classic Papillary Carcinoma as to the Expression of Retinoblastoma Protein and E2F-1 Transcription Factor. Applied Immunohistochemistry & Molecular Morphology 11:1, pages 20-27.
Crossref
Faten Anwar. (2003) Applied Immunohistochemistry 11:1, pages 20-27.
Crossref
Frederick A. Dick & Nicholas J. Dyson. (2002) Three Regions of the pRB Pocket Domain Affect Its Inactivation by Human Papillomavirus E7 Proteins. Journal of Virology 76:12, pages 6224-6234.
Crossref
Shijie Xin, Li Weng, Jinhua Xu & Wei Du. (2002) The role of RBF in developmentally regulated cell proliferation in the eye disc and in Cyclin D/Cdk4 induced cellular growth. Development 129:6, pages 1345-1356.
Crossref
Kristine Bjerve Gützkow, Soheil Naderi & Heidi K. Blomhoff. (2002) Forskolin-mediated G1 arrest in acute lymphoblastic leukaemia cells: phosphorylated pRB sequesters E2Fs. Journal of Cell Science 115:5, pages 1073-1082.
Crossref
Kiyoshi Suzuma, Noriko Takahara, Izumi Suzuma, Keiji Isshiki, Kohjiro Ueki, Michael Leitges, Lloyd Paul Aiello & George L. King. (2002) Characterization of protein kinase C β isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization. Proceedings of the National Academy of Sciences 99:2, pages 721-726.
Crossref
Zhe Jiang & Eldad Zacksenhaus. (2002) Activation of retinoblastoma protein in mammary gland leads to ductal growth suppression, precocious differentiation, and adenocarcinoma. Journal of Cell Biology 156:1, pages 185-198.
Crossref
Sergio Rutella, Luca Pierelli, Carlo Rumi, Giuseppina Bonanno, Maria Marone, Simona Sica, Ettore Capoluongo, Franco Ameglio, Giovanni Scambia & Giuseppe Leone. (2001) T-cell apoptosis induced by granulocyte colony-stimulating factor is associated with retinoblastoma protein phosphorylation and reduced expression of cyclin-dependent kinase inhibitors. Experimental Hematology 29:4, pages 401-415.
Crossref
Peter D. Adams. (2001) Regulation of the retinoblastoma tumor suppressor protein by cyclin/cdks. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1471:3, pages M123-M133.
Crossref
David DiCiommo, Brenda L. Gallie & Rod Bremner. (2000) Retinoblastoma: the disease, gene and protein provide critical leads to understand cancer. Seminars in Cancer Biology 10:4, pages 255-269.
Crossref
David S. Park, Erick J. Morris, Rod Bremner, Elizabeth Keramaris, Jaya Padmanabhan, Michele Rosenbaum, Michael L. Shelanski, Herbert M. Geller & Lloyd A. Greene. (2000) Involvement of Retinoblastoma Family Members and E2F/DP Complexes in the Death of Neurons Evoked by DNA Damage. The Journal of Neuroscience 20:9, pages 3104-3114.
Crossref
Mary Ellen Lane, Marion Elend, Doris Heidmann, Anabel Herr, Sandra Marzodko, Alf Herzig & Christian F Lehner. (2000) A Screen for Modifiers of Cyclin E Function in Drosophila melanogaster Identifies Cdk2 Mutations, Revealing the Insignificance of Putative Phosphorylation Sites in Cdk2 . Genetics 155:1, pages 233-244.
Crossref
Faten Anwar, Mary J Emond, Rodney A Schmidt, Harry C Hwang & Mary P Bronner. (2000) Retinoblastoma Expression in Thyroid Neoplasms. Modern Pathology 13:5, pages 562-569.
Crossref
Sylvia Barrientes, Carolyn Cooke & David W Goodrich. (2000) Glutamic acid mutagenesis of retinoblastoma protein phosphorylation sites has diverse effects on function. Oncogene 19:4, pages 562-570.
Crossref
Thais M. Sielecki, John F. Boylan, Pamela A. Benfield & George L. Trainor. (2000) Cyclin-Dependent Kinase Inhibitors:  Useful Targets in Cell Cycle Regulation. Journal of Medicinal Chemistry 43:1, pages 1-18.
Crossref

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