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Molecular and Cellular Biology Volume 19, 1999 - Issue 5
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Cell Growth and Development

Cellular Activation Triggered by the Autosomal Dominant Polycystic Kidney Disease Gene Product PKD2

Thierry Arnould1 Department of Medicine, Renal Division Beth Israel Deaconess Medical Center, Boston, Massachusetts02215
,
Lorenz Sellin1 Department of Medicine, Renal Division Beth Israel Deaconess Medical Center, Boston, Massachusetts02215
,
Thomas Benzing1 Department of Medicine, Renal Division Beth Israel Deaconess Medical Center, Boston, Massachusetts02215
,
Leonidas Tsiokas1 Department of Medicine, Renal Division Beth Israel Deaconess Medical Center, Boston, Massachusetts02215
,
Herbert T. Cohen2 Renal Section, Department of Medicine, Boston University Medical Center, Boston, Massachusetts02118
,
Emily Kim3 Laboratory of Molecular and Developmental Neuroscience, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts02114
&
Gerd Walz1 Department of Medicine, Renal Division Beth Israel Deaconess Medical Center, Boston, Massachusetts02215Correspondence[email protected]
 show all
Pages 3423-3434 | Received 13 Nov 1998, Accepted 19 Jan 1999, Published online: 28 Mar 2023

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Gregory T Everson, Steve M Helmke & Brian Doctor. (2008) Advances in management of polycystic liver disease. Expert Review of Gastroenterology & Hepatology 2:4, pages 563-576.
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Masumi Maruyama, Yuki Yagasaki, Tatsuhiko Sudo & Hiroyuki Osada. (2003) Renal Abnormalities in Mice Caused by Insufficiency of p38α. Journal of Receptors and Signal Transduction 23:2-3, pages 173-183.
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Jana Reiterová & Vladimír Tesař. (2022) Autosomal Dominant Polycystic Kidney Disease: From Pathophysiology of Cystogenesis to Advances in the Treatment. International Journal of Molecular Sciences 23:6, pages 3317.
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Núria M. Pastor-Soler, Hui Li, Jessica Pham, Daniel Rivera, Pei-Yin Ho, Valeria Mancino, Biagio Saitta & Kenneth R. Hallows. (2022) Metformin improves relevant disease parameters in an autosomal dominant polycystic kidney disease mouse model. American Journal of Physiology-Renal Physiology 322:1, pages F27-F41.
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Xinyu Weng, Liming Yu, Peng Liang, Dewei Chen, Xian Cheng, Yuyu Yang, Luyang Li, Ting Zhang, Bisheng Zhou, Xiaoyan Wu, Huihui Xu, Mingming Fang, Yuqi Gao, Qi Chen & Yong Xu. (2015) Endothelial MRTF-A mediates angiotensin II induced cardiac hypertrophy. Journal of Molecular and Cellular Cardiology 80, pages 23-33.
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David Merrick, Claudia A. Bertuccio, Hannah C. Chapin, Mark Lal, Veronique Chauvet & Michael J. Caplan. (2013) Polycystin-1 cleavage and the regulation of transcriptional pathways. Pediatric Nephrology 29:4, pages 505-511.
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Angela Sun, Raymond Y. Wang & Dechu P. Puliyanda. 2013. Emery and Rimoin's Principles and Practice of Medical Genetics. Emery and Rimoin's Principles and Practice of Medical Genetics 1 33 .
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Kyriacos N Felekkis, Panayiota Koupepidou, Evdokia Kastanos, Ralph Witzgall, Chang-Xi Bai, Li Li, Leonidas Tsiokas, Norbert Gretz & Constantinos Deltas. (2008) Mutant polycystin-2 induces proliferation in primary rat tubular epithelial cells in a STAT-1/p21-independent fashion accompanied instead by alterations in expression of p57KIP2and Cdk2. BMC Nephrology 9:1.
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Michael Köttgen, Björn Buchholz, Miguel A. Garcia-Gonzalez, Fruzsina Kotsis, Xiao Fu, Mara Doerken, Christopher Boehlke, Daniel Steffl, Robert Tauber, Tomasz Wegierski, Roland Nitschke, Makoto Suzuki, Albrecht Kramer-Zucker, Gregory G. Germino, Terry Watnick, Jean Prenen, Bernd Nilius, E. Wolfgang Kuehn & Gerd Walz. (2008) TRPP2 and TRPV4 form a polymodal sensory channel complex. The Journal of Cell Biology 182:3, pages 437-447.
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Thomas Weimbs. (2007) Polycystic kidney disease and renal injury repair: common pathways, fluid flow, and the function of polycystin-1. American Journal of Physiology-Renal Physiology 293:5, pages F1423-F1432.
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Michael Köttgen. (2007) TRPP2 and autosomal dominant polycystic kidney disease. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1772:8, pages 836-850.
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Uma Basavanna, Kimberly M. Weber, Qinghua Hu, Roy C. Ziegelstein, Gregory G. Germino & Michael Sutters. (2007) The isolated polycystin-1 COOH-terminal can activate or block polycystin-1 signaling. Biochemical and Biophysical Research Communications 359:2, pages 367-372.
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Amirali Masoumi, Berenice Reed-Gitomer, Catherine Kelleher & Robert W Schrier. (2007) Potential Pharmacological Interventions in Polycystic Kidney Disease. Drugs 67:17, pages 2495-2510.
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Dominique Joly, Shuta Ishibe, Christian Nickel, Zhiheng Yu, Stefan Somlo & Lloyd G. Cantley. (2006) The Polycystin 1-C-terminal Fragment Stimulates ERK-dependent Spreading of Renal Epithelial Cells. Journal of Biological Chemistry 281:36, pages 26329-26339.
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Jonathan M. ShillingfordNoel S. MurciaClaire H. Larson, Seng Hui LowRyan Hedgepeth, Nicole BrownChris A. FlaskAndrew C. Novick, David A. Goldfarb, Albrecht Kramer-Zucker, Gerd Walz, Klaus B. Piontek, Gregory G. Germino & Thomas Weimbs. (2006) The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease. Proceedings of the National Academy of Sciences 103:14, pages 5466-5471.
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David H. Grimm, Anil Karihaloo, Yiqiang Cai, Stefan Somlo, Lloyd G. Cantley & Michael J. Caplan. (2006) Polycystin-2 Regulates Proliferation and Branching Morphogenesis in Kidney Epithelial Cells. Journal of Biological Chemistry 281:1, pages 137-144.
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R. Brian Doctor, S. Russell Nash, Matthew T. Nichols & Gregory T. Everson. 2006. Zakim and Boyer's Hepatology. Zakim and Boyer's Hepatology 1329 1353 .
Dayong Qiu, Shing-Ming Cheng, Laryssa Wozniak, Megan McSweeney, Emily Perrone & Michael Levin. (2005) Localization and loss-of-function implicates ciliary proteins in early, cytoplasmic roles in left-right asymmetry. Developmental Dynamics 234:1, pages 176-189.
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Albert C.M. Ong & Peter C. Harris. (2005) Molecular pathogenesis of ADPKD: The polycystin complex gets complex. Kidney International 67:4, pages 1234-1247.
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Lisa M. Guay-Woodford. (2004) RIP-ed and ready to dance: new mechanisms for polycystin-1 signaling. Journal of Clinical Investigation 114:10, pages 1404-1406.
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Lisa M. Guay-Woodford. (2004) RIP-ed and ready to dance: new mechanisms for polycystin-1 signaling. Journal of Clinical Investigation 114:10, pages 1404-1406.
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Dana R. Rundle, Gary Gorbsky & Leonidas Tsiokas. (2004) PKD2 Interacts and Co-localizes with mDia1 to Mitotic Spindles of Dividing Cells. Journal of Biological Chemistry 279:28, pages 29728-29739.
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Patricia D. Wilson. (2004) Polycystic Kidney Disease. New England Journal of Medicine 350:2, pages 151-164.
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Martijn S Scheffers, Paola van der Bent, Annemieke van de Wal, Jaap van Eendenburg, Martijn H Breuning, Emile de Heer & Dorien J.M Peters. (2004) Altered distribution and co-localization of polycystin-2 with polycystin-1 in MDCK cells after wounding stress. Experimental Cell Research 292:1, pages 219-230.
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Stephen C. Parnell, Brenda S. Magenheimer, Robin L. Maser, Christopher A. Zien, Anna-Maria Frischauf & James P. Calvet. (2002) Polycystin-1 Activation of c-Jun N-terminal Kinase and AP-1 Is Mediated by Heterotrimeric G Proteins. Journal of Biological Chemistry 277:22, pages 19566-19572.
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David H. Vandorpe, Sabine Wilhelm, Lianwei Jiang, Oxana Ibraghimov-Beskrovnaya, Marina N. Chernova, Alan K. Stuart-Tilley & Seth L. Alper. (2002) Cation channel regulation by COOH-terminal cytoplasmic tail of polycystin-1: mutational and functional analysis. Physiological Genomics 8:2, pages 87-98.
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Christian Nickel, Thomas Benzing, Lorenz Sellin, Peter Gerke, Anil Karihaloo, Zhen-Xiang Liu, Lloyd G. Cantley & Gerd Walz. (2002) The polycystin-1 C-terminal fragment triggers branching morphogenesis and migration of tubular kidney epithelial cells. Journal of Clinical Investigation 109:4, pages 481-489.
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Tobias B. Huber, Michael Köttgen, Birgit Schilling, Gerd Walz & Thomas Benzing. (2001) Interaction with Podocin Facilitates Nephrin Signaling. Journal of Biological Chemistry 276:45, pages 41543-41546.
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Jared J. Grantham & James P. Calvet. (2001) Polycystic kidney disease: In danger of being X-rated?. Proceedings of the National Academy of Sciences 98:3, pages 790-792.
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Joshua H. LipschutzWei Guo, Lucy E. O'Brien, Yen H. Nguyen, Peter Novick & Keith E. Mostov. (2000) Exocyst Is Involved in Cystogenesis and Tubulogenesis and Acts by Modulating Synthesis and Delivery of Basolateral Plasma Membrane and Secretory Proteins. Molecular Biology of the Cell 11:12, pages 4259-4275.
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Anna Rachel Gallagher, Anna Cedzich, Norbert Gretz, Stefan Somlo & Ralph Witzgall. (2000) The polycystic kidney disease protein PKD2 interacts with Hax-1, a protein associated with the actin cytoskeleton. Proceedings of the National Academy of Sciences 97:8, pages 4017-4022.
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