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Molecular and Cellular Biology Volume 19, 1999 - Issue 5
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Transcriptional Regulation

Reciprocal Modulatory Interaction between Human Immunodeficiency Virus Type 1 Tat and Transcription Factor NFAT1

Fernando MaciánDepartment of Pathology, Harvard Medical School, and Center for Blood Research, Boston, Massachusetts02115
&
Anjana RaoDepartment of Pathology, Harvard Medical School, and Center for Blood Research, Boston, Massachusetts02115Correspondence[email protected]
Pages 3645-3653 | Received 16 Dec 1998, Accepted 09 Feb 1999, Published online: 28 Mar 2023

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Roger G Ptak. (2002) HIV-1 regulatory proteins: targets for novel drug development. Expert Opinion on Investigational Drugs 11:8, pages 1099-1115.
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Aneta Pluta, Juan P. Jaworski & César N. Cortés-Rubio. (2020) Balance between Retroviral Latency and Transcription: Based on HIV Model. Pathogens 10:1, pages 16.
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Enrico Ne, Robert-Jan Palstra & Tokameh Mahmoudi. 2018. Transcriptional Gene Regulation in Health and Disease. Transcriptional Gene Regulation in Health and Disease 191 243 .
Chang-Suk Chae, Gi-Cheon Kim, Eun Sil Park, Choong-Gu Lee, Ravi Verma, Hagg-Lim Cho, Chang-Duk Jun, Yung Joon Yoo & Sin-Hyeog Im. (2017) NFAT1 Regulates Systemic Autoimmunity through the Modulation of a Dendritic Cell Property. The Journal of Immunology 199:9, pages 3051-3062.
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Jamie I. MacPherson, Jonathan E. Dickerson, John W. Pinney & David L. Robertson. (2010) Patterns of HIV-1 Protein Interaction Identify Perturbed Host-Cellular Subsystems. PLoS Computational Biology 6:7, pages e1000863.
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Randy Q. Cron. (2001) HIV-1, NFAT, and Cyclosporin: Immunosuppression for the Immunosuppressed?. DNA and Cell Biology 20:12, pages 761-767.
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Benoit Barbeau, Gilles A. Robichaud, Jean-François Fortin & Michel J. Tremblay. (2001) Negative Regulation of the NFAT1 Factor by CD45: Implication in HIV-1 Long Terminal Repeat Activation. The Journal of Immunology 167:5, pages 2700-2713.
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Marta Gómez-Gonzalo, Marta Carretero, Joaquı́n Rullas, Enrique Lara-Pezzi, José Aramburu, Benjamin Berkhout, José Alcamı́ & Manuel López-Cabrera. (2001) The Hepatitis B Virus X Protein Induces HIV-1 Replication and Transcription in Synergy with T-cell Activation Signals. Journal of Biological Chemistry 276:38, pages 35435-35443.
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Cristina López-Rodrı́guez, José Aramburu, Lei Jin, Andrew S Rakeman, Mayako Michino & Anjana Rao. (2001) Bridging the NFAT and NF-κB Families. Immunity 15:1, pages 47-58.
Crossref
Fernando Macián, Cristina López-Rodríguez & Anjana Rao. (2001) Partners in transcription: NFAT and AP-1. Oncogene 20:19, pages 2476-2489.
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Jean-François FortinBenoit BarbeauGilles A. RobichaudMarie-Ève ParéAnne-Marie LemieuxMichel J. Tremblay. (2001) Regulation of nuclear factor of activated T cells by phosphotyrosyl-specific phosphatase activity: a positive effect on HIV-1 long terminal repeat–driven transcription and a possible implication of SHP-1. Blood 97:8, pages 2390-2400.
Crossref
Esther González, Carmen Punzón, Manuel González & Manuel Fresno. (2001) HIV-1 Tat Inhibits IL-2 Gene Transcription Through Qualitative and Quantitative Alterations of the Cooperative Rel/AP1 Complex Bound to the CD28RE/AP1 Composite Element of the IL-2 Promoter. The Journal of Immunology 166:7, pages 4560-4569.
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Robert L. Caldwell, Brian S. Egan & Virginia L. Shepherd. (2000) HIV-1 Tat Represses Transcription from the Mannose Receptor Promoter. The Journal of Immunology 165:12, pages 7035-7041.
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Crossref
Adele F. Holloway, Filomena Occhiodoro, Gerhard Mittler, Michael Meisterernst & M.Frances Shannon. (2000) Functional Interaction between the HIV Transactivator Tat and the Transcriptional Coactivator PC4 in T Cells. Journal of Biological Chemistry 275:28, pages 21668-21677.
Crossref
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Crossref
Randy Q. Cron, Steven R. Bartz, Adrian Clausell, Susan J. Bort, Seymour J. Klebanoff & David B. Lewis. (2000) NFAT1 Enhances HIV-1 Gene Expression in Primary Human CD4 T Cells. Clinical Immunology 94:3, pages 179-191.
Crossref
Arnold B. Rabson & Hsin-Ching Lin. 2000. HIV-1: Molecular Biology and Pathogenesis Viral Mechanisms. HIV-1: Molecular Biology and Pathogenesis Viral Mechanisms 161 207 .
O. Rohr, B. E. Sawaya, D. Lecestre, D. Aunis & E. Schaeffer. (1999) Dopamine stimulates expression of the human immunodeficiency virus type 1 via NF- B in cells of the immune system. Nucleic Acids Research 27:16, pages 3291-3299.
Crossref
C. LOPEZ-RODRIGUEZ, J. ARAMBURU, A.S. RAKEMAN, N.G. COPELAND, D.J. GILBERT, S. THOMAS, C. DISTECHE, N.A. JENKINS & A. RAO. (1999) NF-AT5: The NF-AT Family of Transcription Factors Expands in a New Direction. Cold Spring Harbor Symposia on Quantitative Biology 64:0, pages 517-526.
Crossref

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