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Molecular and Cellular Biology Volume 19, 1999 - Issue 5
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Cell Growth and Development

Hepatocyte Growth Factor Releases Mink Epithelial Cells from Transforming Growth Factor β1-Induced Growth Arrest by Restoring Cdk6 Expression and Cyclin E-Associated Cdk2 Activity

Minna TsubariDepartment of Virology, Haartman Institute, University of Helsinki, Helsinki, Finland
,
Jussi TaipaleDepartment of Virology, Haartman Institute, University of Helsinki, Helsinki, Finland
,
Erja TiihonenDepartment of Virology, Haartman Institute, University of Helsinki, Helsinki, Finland
,
Jorma Keski-OjaDepartment of Virology, Haartman Institute, University of Helsinki, Helsinki, Finland
&
Marikki LaihoDepartment of Virology, Haartman Institute, University of Helsinki, Helsinki, FinlandCorrespondence[email protected]
Pages 3654-3663 | Received 22 May 1998, Accepted 22 Feb 1999, Published online: 28 Mar 2023

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Shiri Kfir, Marcelo Ehrlich, Ayelet Goldshmid, Xuedong Liu, Yoel Kloog & Yoav I. Henis. (2005) Pathway- and Expression Level-Dependent Effects of Oncogenic N-Ras: p27Kip1 Mislocalization by the Ral-GEF Pathway and Erk-Mediated Interference with Smad Signaling. Molecular and Cellular Biology 25:18, pages 8239-8250.
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Kevin A. Walter, Mir Ahamed Hossain, Carey Luddy, Nidhi Goel, Thomas E. Reznik & John Laterra. (2002) Scatter Factor/Hepatocyte Growth Factor Stimulation of Glioblastoma Cell Cycle Progression through G1 Is c-Myc Dependent and Independent of p27 Suppression, Cdk2 Activation, or E2F1-Dependent Transcription. Molecular and Cellular Biology 22:8, pages 2703-2715.
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Liam Cornell, Seth A. Wander, Tanvi Visal, Nikhil Wagle & Geoffrey I. Shapiro. (2019) MicroRNA-Mediated Suppression of the TGF-β Pathway Confers Transmissible and Reversible CDK4/6 Inhibitor Resistance. Cell Reports 26:10, pages 2667-2680.e7.
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Shinya Mizuno & Yoko Mizuno-Horikawa. (2016) Up-Regulation of Local TGF-β Contributes to a Decrease in Renal Tubular Na<sup>+</sup>-K<sup>+</sup> ATPase and Hyperkalemia in a Mouse Model of Crush Syndrome. Pharmacology & Pharmacy 07:12, pages 481-492.
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Keren Tazat, Meirav Harsat, Ayelet Goldshmid-Shagal, Marcelo Ehrlich & Yoav I. Henis. (2013) Dual effects of Ral-activated pathways on p27 localization and TGF-β signaling. Molecular Biology of the Cell 24:11, pages 1812-1824.
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Y-H Lee, A D Judge, D Seo, M Kitade, L E Gómez-Quiroz, T Ishikawa, J B Andersen, B-K Kim, J U Marquardt, C Raggi, I Avital, E A Conner, I MacLachlan, V M Factor & S S Thorgeirsson. (2011) Molecular targeting of CSN5 in human hepatocellular carcinoma: a mechanism of therapeutic response. Oncogene 30:40, pages 4175-4184.
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Mia A. Björklund, Kari Vaahtomeri, Karita Peltonen, Benoît Viollet, Tomi P. Mäkelä, Arja M. Band & Marikki Laiho. (2010) Non-CDK-bound p27 (p27NCDK) is a marker for cell stress and is regulated through the Akt/PKB and AMPK-kinase pathways. Experimental Cell Research 316:5, pages 762-774.
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Il Je Cho, Dae Ki Sung, Keon Wook Kang & Sang Geon Kim. (2009) Oltipraz promotion of liver regeneration after partial hepatectomy: The role of PI3-kinase-dependent C/EBPβ and cyclin E regulation. Archives of Pharmacal Research 32:4, pages 625-635.
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Young-Sil Yoon, Jae-Ho Lee, Sung-Chul Hwang, Kyeong Sook Choi & Gyesoon Yoon. (2005) TGF β1 induces prolonged mitochondrial ROS generation through decreased complex IV activity with senescent arrest in Mv1Lu cells. Oncogene 24:11, pages 1895-1903.
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Yonglong Zou, Daina Z. Ewton, Xiaobing Deng, Stephen E. Mercer & Eileen Friedman. (2004) Mirk/dyrk1B Kinase Destabilizes Cyclin D1 by Phosphorylation at Threonine 288. Journal of Biological Chemistry 279:26, pages 27790-27798.
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Wei Wang, Dana Ungermannova, Jianpin Jin, J Wade Harper & Xuedong Liu. (2003) Negative regulation of SCFSkp2 ubiquitin ligase by TGF-β signaling. Oncogene 23:5, pages 1064-1075.
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Miaofen G. Hu, Guo-Fu Hu, Yong Kim, Takanori Tsuji, Jim McBride, Philip Hinds & David T. W. Wong. (2004) Role of p12CDK2-AP1 in Transforming Growth Factor-β1-Mediated Growth Suppression. Cancer Research 64:2, pages 490-499.
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Yonglong Zou, Seunghwan Lim, Kangmoon Lee, Xiaobing Deng & Eileen Friedman. (2003) Serine/Threonine Kinase Mirk/Dyrk1B Is an Inhibitor of Epithelial Cell Migration and Is Negatively Regulated by the Met Adaptor Ran-binding Protein M. Journal of Biological Chemistry 278:49, pages 49573-49581.
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Katia Coulonval, Laurence Bockstaele, Sabine Paternot, Jacques E Dumont & Pierre P Roger. (2003) The cyclin D3-CDK4-p27kip1 holoenzyme in thyroid epithelial cells: activation by TSH, inhibition by TGFβ, and phosphorylations of its subunits demonstrated by two-dimensional gel electrophoresis. Experimental Cell Research 291:1, pages 135-149.
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Edward MelkunMylisa PilioneRobert F. Paulson. (2002) A naturally occurring point substitution in Cdc25A, and not Fv2/Stk, is associated with altered cell-cycle status of early erythroid progenitor cells. Blood 100:10, pages 3804-3811.
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Dug Keun Lee, Byung-Chul Kim, Isaac Yi Kim, Eun-ah Cho, Daniel J. Satterwhite & Seong-Jin Kim. (2002) The Human Papilloma Virus E7 Oncoprotein Inhibits Transforming Growth Factor-β Signaling by Blocking Binding of the Smad Complex to Its Target Sequence. Journal of Biological Chemistry 277:41, pages 38557-38564.
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Fan Zhang, Mia Mönkkönen, Stina Roth & Marikki Laiho. (2002) Proteasomal activity modulates TGF-ß signaling in a gene-specific manner. FEBS Letters 527:1-3, pages 58-62.
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Yael Leshem & Orna Halevy. (2002) Phosphorylation of pRb is required for HGF-induced muscle cell proliferation and is p27kip1-dependent. Journal of Cellular Physiology 191:2, pages 173-182.
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Kazutaka Takami, Noriko Takuwa, Hitoshi Okazaki, Masato Kobayashi, Takayuki Ohtoshi, Shin Kawasaki, Makoto Dohi, Kazuhiko Yamamoto, Toshikazu Nakamura, Mitsuru Tanaka, Kazuhiko Nakahara, Yoh Takuwa & Hajime Takizawa. (2002) Interferon- γ Inhibits Hepatocyte Growth Factor-Stimulated Cell Proliferation of Human Bronchial Epithelial Cells. American Journal of Respiratory Cell and Molecular Biology 26:2, pages 231-238.
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Fan Zhang, Minna Taipale, Annamari Heiskanen & Marikki Laiho. (2001) Ectopic expression of Cdk6 circumvents transforming growth factor-β mediated growth inhibition. Oncogene 20:41, pages 5888-5896.
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Sang Gyun Kim, Se Nyun Kim, Hyun-Soon Jong, Noe Kyeong Kim, Seung Hwan Hong, Seong-Jin Kim & Yung-Jue Bang. (2001) Caspase-mediated Cdk2 activation is a critical step to execute transforming growth factor-β1-induced apoptosis in human gastric cancer cells. Oncogene 20:10, pages 1254-1265.
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X LIU, Y SUN, R WEINBERG & H LODISH. (2001) Ski/Sno and TGF-β signaling. Cytokine & Growth Factor Reviews 12:1, pages 1-8.
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Xuedong Liu, Yin Sun, Marcelo Ehrlich, Trent Lu, Yoel Kloog, Robert A Weinberg, Harvey F Lodish & Yoav I Henis. (2000) Disruption of TGF-β growth inhibition by oncogenic ras is linked to p27Kip1 mislocalization. Oncogene 19:51, pages 5926-5935.
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Sonnie Kirk, Jenny Oldham, Ravi Kambadur, Mridula Sharma, Pete Dobbie & John Bass. (2000) Myostatin regulation during skeletal muscle regeneration. Journal of Cellular Physiology 184:3, pages 356-363.
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Minna Taipale, Erja Tiihonen, Annamari Heiskanen & Marikki Laiho. (2000) Accumulation of a Form of p27Kip1 Not Associated with Cdk–Cyclin Complexes in Transforming Growth Factor-β-Arrested Mv1Lu Cells. Experimental Cell Research 259:1, pages 107-116.
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Fabienne Depoortere, Isabelle Pirson, Jiri Bartek, Jacques E. Dumont & Pierre P. Roger. (2000) Transforming Growth Factor β 1 Selectively Inhibits the Cyclic AMP-dependent Proliferation of Primary Thyroid Epithelial Cells by Preventing the Association of Cyclin D3–cdk4 with Nuclear p27 kip1 . Molecular Biology of the Cell 11:3, pages 1061-1076.
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