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Molecular and Cellular Biology Volume 19, 1999 - Issue 5
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Cell Growth and Development

hSiah2 Is a New Vav Binding Protein Which Inhibits Vav-Mediated Signaling Pathways

Antonia GermaniInstitut Cochin de Génétique Moléculaire, U363 INSERM, Hôpital Cochin, Université Paris V, 75014Paris, FranceCorrespondence[email protected]
,
Francisco RomeroInstitut Cochin de Génétique Moléculaire, U363 INSERM, Hôpital Cochin, Université Paris V, 75014Paris, France
,
Martin HoulardInstitut Cochin de Génétique Moléculaire, U363 INSERM, Hôpital Cochin, Université Paris V, 75014Paris, France
,
Jacques CamonisInstitut Cochin de Génétique Moléculaire, U363 INSERM, Hôpital Cochin, Université Paris V, 75014Paris, France
,
Sylvie GisselbrechtInstitut Cochin de Génétique Moléculaire, U363 INSERM, Hôpital Cochin, Université Paris V, 75014Paris, France
,
Siegmund FischerInstitut Cochin de Génétique Moléculaire, U363 INSERM, Hôpital Cochin, Université Paris V, 75014Paris, France
&
Nadine Varin-BlankInstitut Cochin de Génétique Moléculaire, U363 INSERM, Hôpital Cochin, Université Paris V, 75014Paris, France
 show all
Pages 3798-3807 | Received 03 Sep 1998, Accepted 25 Jan 1999, Published online: 28 Mar 2023

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Ian J. Frew, Vicki E. Hammond, Ross A. Dickins, Julian M. W. Quinn, Carl R. Walkley, Natalie A. Sims, Ralf Schnall, Neil G. Della, Andrew J. Holloway, Matthew R. Digby, Peter W. Janes, David M. Tarlinton, Louise E. Purton, Matthew T. Gillespie & David D. L. Bowtell. (2003) Generation and Analysis of Siah2 Mutant Mice. Molecular and Cellular Biology 23:24, pages 9150-9161.
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Songhui Li, Chunyan Xu & Richard W. Carthew. (2002) Phyllopod Acts as an Adaptor Protein To Link the Sina Ubiquitin Ligase to the Substrate Protein Tramtrack. Molecular and Cellular Biology 22:19, pages 6854-6865.
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Ross A. Dickins, Ian J. Frew, Colin M. House, Moira K. O'Bryan, Andrew J. Holloway, Izhak Haviv, Nadia Traficante, David M. de Kretser & David D. L. Bowtell. (2002) The Ubiquitin Ligase Component Siah1a Is Required for Completion of Meiosis I in Male Mice. Molecular and Cellular Biology 22:7, pages 2294-2303.
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Liyu Zeng, Pallavi Sachdev, Lunbiao Yan, Joseph L. Chan, Thomas Trenkle, Michael McClelland, John Welsh & Lu-Hai Wang. (2000) Vav3 Mediates Receptor Protein Tyrosine Kinase Signaling, Regulates GTPase Activity, Modulates Cell Morphology, and Induces Cell Transformation. Molecular and Cellular Biology 20:24, pages 9212-9224.
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Xosé R. Bustelo. (2000) Regulatory and Signaling Properties of the Vav Family. Molecular and Cellular Biology 20:5, pages 1461-1477.
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Articles from other publishers (26)

Jie Sun, Xiaojuan Zhang, Yanchun Han, Juan Zhen, Yuan Meng & Min Song. (2016) Overexpression of seven in absentia homolog 2 protein in human breast cancer tissues is associated with the promotion of tumor cell malignant behavior in in vitro. Oncology Reports 36:3, pages 1301-1312.
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O H Krämer, R H Stauber, G Bug, J Hartkamp & S K Knauer. (2012) SIAH proteins: critical roles in leukemogenesis. Leukemia 27:4, pages 792-802.
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Sang Bae Lee, Chung Kwon Kim, Kyung-Hoon Lee & Jee-Yin Ahn. (2012) S-nitrosylation of B23/nucleophosmin by GAPDH protects cells from the SIAH1–GAPDH death cascade. Journal of Cell Biology 199:1, pages 65-76.
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Kristin Pietschmann, Marc Buchwald, Sylvia Müller, Shirley K. Knauer, Manfred Kögl, Thorsten Heinzel & Oliver H. Krämer. (2012) Differential regulation of PML–RARα stability by the ubiquitin ligases SIAH1/SIAH2 and TRIAD1. The International Journal of Biochemistry & Cell Biology 44:1, pages 132-138.
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Heriberto Bruzzoni-Giovanelli, Plinio Fernandez, Lucía Veiga, Marie-Pierre Podgorniak, Darren J Powell, Marco M Candeias, Samia Mourah, Fabien Calvo & Mónica Marín. (2010) Distinct expression patterns of the E3 ligase SIAH-1 and its partner Kid/KIF22 in normal tissues and in the breast tumoral processes. Journal of Experimental & Clinical Cancer Research 29:1.
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Koh Nakayama, Jianfei Qi & Ze'ev Ronai. (2009) The Ubiquitin Ligase Siah2 and the Hypoxia Response. Molecular Cancer Research 7:4, pages 443-451.
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A Depaux, F Regnier-Ricard, A Germani & N Varin-Blank. (2007) A crosstalk between hSiah2 and Pias E3-ligases modulates Pias-dependent activation. Oncogene 26:46, pages 6665-6676.
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Y Mei, C Xie, W Xie, Z Wu & M Wu. (2007) Siah-1S, a novel splice variant of Siah-1 (seven in absentia homolog), counteracts Siah-1-mediated downregulation of β-catenin. Oncogene 26:43, pages 6319-6331.
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Arnaud Depaux, Fabienne Regnier-Ricard, Antonia Germani & Nadine Varin-Blank. (2006) Dimerization of hSiah proteins regulates their stability. Biochemical and Biophysical Research Communications 348:3, pages 857-863.
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Eugenio Santelli, Marilisa Leone, Chenlong Li, Toru Fukushima, Nicholas E. Preece, Arthur J. Olson, Kathryn R. Ely, John C. Reed, Maurizio Pellecchia, Robert C. Liddington & Shu-ichi Matsuzawa. (2005) Structural Analysis of Siah1-Siah-interacting Protein Interactions and Insights into the Assembly of an E3 Ligase Multiprotein Complex. Journal of Biological Chemistry 280:40, pages 34278-34287.
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Martin Houlard, Francisco Romero-Portillo, Antonia Germani, Arnaud Depaux, Fabienne Regnier-Ricard, Sylvie Gisselbrecht & Nadine Varin-Blank. (2004) Characterization of VIK-1: a new Vav-interacting Kruppel-like protein. Oncogene 24:1, pages 28-38.
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Julian P. Venables, Caroline Dalgliesh, Maria Paolo Paronetto, Lindi Skitt, Jared K. Thornton, Philippa T. Saunders, Claudio Sette, Keith T. Jones & David J. Elliott. (2004) SIAH1 targets the alternative splicing factor T-STAR for degradation by the proteasome. Human Molecular Genetics 13:14, pages 1525-1534.
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Antonia Germani, Audrey Prabel, Samia Mourah, Marie-Pierre Podgorniak, Anna Di Carlo, Ricardo Ehrlich, Sylvie Gisselbrecht, Nadine Varin-Blank, Fabien Calvo & Heriberto Bruzzoni-Giovanelli. (2003) SIAH-1 interacts with CtIP and promotes its degradation by the proteasome pathway. Oncogene 22:55, pages 8845-8851.
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Yuko Miura-Shimura, Lei Duan, Navin L. Rao, Alagarsamy L. Reddi, Hideki Shimura, Rob Rottapel, Brain J. Druker, Alexander Tsygankov, Vimla Band & Hamid Band. (2003) Cbl-mediated Ubiquitinylation and Negative Regulation of Vav. Journal of Biological Chemistry 278:40, pages 38495-38504.
Crossref
Colin M. House, Ian J. Frew, Huei-Luen Huang, Gerhard Wiche, Nadia Traficante, Edouard Nice, Bruno Catimel & David D. L. Bowtell. (2003) A binding motif for Siah ubiquitin ligase. Proceedings of the National Academy of Sciences 100:6, pages 3101-3106.
Crossref
Shu-ichi Matsuzawa, Chenglong Li, Chao-Zhou Ni, Shinichi Takayama, John C. Reed & Kathryn R. Ely. (2003) Structural Analysis of Siah1 and Its Interactions with Siah-interacting Protein (SIP). Journal of Biological Chemistry 278:3, pages 1837-1840.
Crossref
Anja Schmidt & Alan Hall. (2002) Guanine nucleotide exchange factors for Rho GTPases: turning on the switch. Genes & Development 16:13, pages 1587-1609.
Crossref
Martin Houlard, Ramachandran Arudchandran, Fabienne Regnier-Ricard, Antonia Germani, Sylvie Gisselbrecht, Ulrich Blank, Juan Rivera & Nadine Varin-Blank. (2002) Vav1 Is a Component of Transcriptionally Active Complexes. Journal of Experimental Medicine 195:9, pages 1115-1127.
Crossref
Florian Bassermann, Thomas Jahn, Cornelius Miething, Petra Seipel, Ren-Yuan Bai, Sunita Coutinho, Christian Peschel, Justus Duyster & Victor L. Tybulewicz. (2002) Association of Bcr-Abl with the Proto-oncogene Vav Is Implicated in Activation of the Rac-1 Pathway. Journal of Biological Chemistry 277:14, pages 12437-12445.
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Tanja Ligensa, Sonia Krauss, Dirk Demuth, Ralf Schumacher, Jacques Camonis, Gabriele Jaques & K. Michael Weidner. (2001) A PDZ Domain Protein Interacts with the C-terminal Tail of the Insulin-like Growth Factor-1 Receptor but Not with the Insulin Receptor. Journal of Biological Chemistry 276:36, pages 33419-33427.
Crossref
Sven Bogdan, Sabine Senkel, Fabian Esser, Gerhart U Ryffel & Elke Pogge v. Strandmann. (2001) Misexpression of Xsiah-2 induces a small eye phenotype in Xenopus. Mechanisms of Development 103:1-2, pages 61-69.
Crossref
Antonia Germani, Heriberto Bruzzoni-Giovanelli, Arlette Fellous, Sylvie Gisselbrecht, Nadine Varin-Blank & Fabien Calvo. (2000) SIAH-1 interacts with α-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis. Oncogene 19:52, pages 5997-6006.
Crossref
Monia Medhioub, Christelle Vaury, Richard Hamelin & Gilles Thomas. (2000) Lack of somatic mutation in the coding sequence ofSIAH1 in tumors hemizygous for this candidate tumor suppressor gene. International Journal of Cancer 87:6, pages 794-797.
Crossref
Steffen P. Hehner, Thomas G. Hofmann, Oliver Dienz, Wulf Dröge & M.Lienhard Schmitz. (2000) Tyrosine-phosphorylated Vav1 as a Point of Integration for T-cell Receptor- and CD28-mediated Activation of JNK, p38, and Interleukin-2 Transcription. Journal of Biological Chemistry 275:24, pages 18160-18171.
Crossref
Paulo De Sepulveda, Subburaj Ilangumaran & Robert Rottapel. (2000) Suppressor of Cytokine Signaling-1 Inhibits VAV Function through Protein Degradation. Journal of Biological Chemistry 275:19, pages 14005-14008.
Crossref
Thomas G Hofmann, Steffen P Hehner, Wulf Dröge & M Lienhard Schmitz. (2000) Caspase-dependent cleavage and inactivation of the Vav1 proto-oncogene product during apoptosis prevents IL-2 transcription. Oncogene 19:9, pages 1153-1163.
Crossref

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