Advanced search
Publication Cover
Molecular and Cellular Biology Volume 19, 1999 - Issue 5
Submit an article Journal homepage
11
Views
73
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Distinct Regulation of p53 and p73 Activity by Adenovirus E1A, E1B, and E4orf6 Proteins

Wilma T. Steegenga1 Laboratory for Physiological Chemistry and Centre for Biomedical Genetics, Utrecht University, 3508 TAUtrechtCorrespondence[email protected]
,
Avi Shvarts2 Department of Molecular Carcinogenesis and Centre for Biomedical Genetics, The Netherlands Cancer Institute, 1066 CXAmsterdam
,
Nicole Riteco1 Laboratory for Physiological Chemistry and Centre for Biomedical Genetics, Utrecht University, 3508 TAUtrecht
,
Johannes L. Bos1 Laboratory for Physiological Chemistry and Centre for Biomedical Genetics, Utrecht University, 3508 TAUtrecht
&
Aart G. Jochemsen3 Laboratory of Molecular Carcinogenesis and Centre for Biomedical Genetics, Leiden University Medical Center, 2300 RALeiden, The Netherlands
Pages 3885-3894 | Received 24 Aug 1998, Accepted 18 Feb 1999, Published online: 28 Mar 2023

Citations (73)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Yijing Jiang, Jie Zhang, Dan Guo, Chenlu Zhang, Lemin Hong, Hongming Huang & Haiyan Liu. (2020) Entire ABL1 Gene Deletion Without BCR/ABL1 Rearrangement in a Female Patient with B-Cell Precursor Acute Lymphoblastic Leukemia. OncoTargets and Therapy 13, pages 783-790.
Read now
Takahito Nakagawa, Masato Takahashi, Toshinori Ozaki, Ken-ichi Watanabe, Satoru Todo, Hiroyuki Mizuguchi, Takao Hayakawa & Akira Nakagawara. (2002) Autoinhibitory Regulation of p73 by ΔNp73 To Modulate Cell Survival and Death through a p73-Specific Target Element within the ΔNp73 Promoter. Molecular and Cellular Biology 22:8, pages 2575-2585.
Read now

Articles from other publishers (71)

Sonia Marquez-Martinez, Aneesh Vijayan, Selina Khan & Roland Zahn. (2023) Cell entry and innate sensing shape adaptive immune responses to adenovirus-based vaccines. Current Opinion in Immunology 80, pages 102282.
Crossref
Schwartze JT, Havenga M, Bakker WAM, Bradshaw AC & Nicklin SA. (2022) Adenoviral vectors for cardiovascular gene therapy applications: a clinical and industry perspective. Journal of Molecular Medicine 100:6, pages 875-901.
Crossref
Marie Fiedler, Wing-Hang Ip, Helga Hofmann-Sieber, Britta Wilkens, Francis K. Nkrumah, Wenli Zhang, Anja Ehrhardt, Luca D. Bertzbach & Thomas Dobner. (2022) Protein–Protein Interactions Facilitate E4orf6-Dependent Regulation of E1B-55K SUMOylation in HAdV-C5 Infection. Viruses 14:3, pages 463.
Crossref
Martin A. Prusinkiewicz & Joe S. Mymryk. (2021) Metabolic Control by DNA Tumor Virus-Encoded Proteins. Pathogens 10:5, pages 560.
Crossref
Chao Wang, Cui Rong Teo & Kanaga Sabapathy. (2020) p53-Related Transcription Targets of TAp73 in Cancer Cells—Bona Fide or Distorted Reality?. International Journal of Molecular Sciences 21:4, pages 1346.
Crossref
Thomas Speiseder, Helga Hofmann-Sieber, Estefanía Rodríguez, Anna Schellenberg, Nuray Akyüz, Judith Dierlamm, Thilo Spruss, Claudia Lange & Thomas Dobner. (2017) Efficient Transformation of Primary Human Mesenchymal Stromal Cells by Adenovirus Early Region 1 Oncogenes. Journal of Virology 91:1.
Crossref
Cristian Capasso, Mariangela Garofalo, Mari Hirvinen & Vincenzo Cerullo. (2014) The Evolution of Adenoviral Vectors through Genetic and Chemical Surface Modifications. Viruses 6:2, pages 832-855.
Crossref
S Santag, W Jäger, C B Karsten, S Kati, M Pietrek, D Steinemann, G Sarek, P M Ojala & T F Schulz. (2012) Recruitment of the tumour suppressor protein p73 by Kaposi’s Sarcoma Herpesvirus latent nuclear antigen contributes to the survival of primary effusion lymphoma cells. Oncogene 32:32, pages 3676-3685.
Crossref
Jasdave S. Chahal, Courtney Gallagher, Caroline J. DeHart & S. J. Flint. (2013) The Repression Domain of the E1B 55-Kilodalton Protein Participates in Countering Interferon-Induced Inhibition of Adenovirus Replication. Journal of Virology 87:8, pages 4432-4444.
Crossref
Florian Kühnel, Engin Gürlevik, Thomas C Wirth, Nina Strüver, Nisar P Malek, Martina Müller-Schilling, Michael P Manns, Amancio Carnero, Lars Zender & Stefan Kubicka. (2010) Targeting of p53-Transcriptional Dysfunction by Conditionally Replicating Adenovirus Is Not Limited by p53-Homologues. Molecular Therapy 18:5, pages 936-946.
Crossref
Melda Tozluoğlu, Ezgi Karaca, Turkan Haliloglu & Ruth Nussinov. (2008) Cataloging and organizing p73 interactions in cell cycle arrest and apoptosis. Nucleic Acids Research 36:15, pages 5033-5049.
Crossref
H B Fleisig, N I Orazio, H Liang, A F Tyler, H P Adams, M D Weitzman & L Nagarajan. (2007) Adenoviral E1B55K oncoprotein sequesters candidate leukemia suppressor sequence-specific single-stranded DNA-binding protein 2 into aggresomes. Oncogene 26:33, pages 4797-4805.
Crossref
Kamyar Zahedi, John J. Bissler, Zhaohui Wang, Anuradha Josyula, Lu Lu, Paula Diegelman, Nick Kisiel, Carl W. Porter & Manoocher Soleimani. (2007) Spermidine/spermine N 1 -acetyltransferase overexpression in kidney epithelial cells disrupts polyamine homeostasis, leads to DNA damage, and causes G 2 arrest . American Journal of Physiology-Cell Physiology 292:3, pages C1204-C1215.
Crossref
Stephanie Si Liu, Kelvin Yuen-Kwong Chan, Rebecca Ching-Yu Leung, Helen Ka-Wai Law, Tsin-Wah Leung & Hextan Yuen-Sheung Ngan. (2006) Enhancement of the radiosensitivity of cervical cancer cells by overexpressing p73α. Molecular Cancer Therapeutics 5:5, pages 1209-1215.
Crossref
Toshinori Ozaki & Akira Nakagawara. (2005) p73, a sophisticated p53 family member in the cancer world. Cancer Science 96:11, pages 729-737.
Crossref
Keith Meyer, Arnab Basu, Kousuke Saito, Ratna B. Ray & Ranjit Ray. (2005) Inhibition of hepatitis C virus core protein expression in immortalized human hepatocytes induces cytochrome c-independent increase in Apaf-1 and caspase-9 activation for cell death. Virology 336:2, pages 198-207.
Crossref
Takayuki Hanamoto, Toshinori Ozaki, Kazushige Furuya, Mitsuchika Hosoda, Syunji Hayashi, Mitsuru Nakanishi, Hideki Yamamoto, Hironobu Kikuchi, Satoru Todo & Akira Nakagawara. (2005) Identification of Protein Kinase A Catalytic Subunit β as a Novel Binding Partner of p73 and Regulation of p73 Function. Journal of Biological Chemistry 280:17, pages 16665-16675.
Crossref
Marcella Flinterman, Lars Guelen, Samira Ezzati-Nik, Richard Killick, Gerry Melino, Kazuya Tominaga, Joe S. Mymryk, Joop Gäken & Mahvash Tavassoli. (2005) E1A Activates Transcription of p73 and Noxa to Induce Apoptosis. Journal of Biological Chemistry 280:7, pages 5945-5959.
Crossref
Ute M. Moll & Neda Slade. (2004) p63 and p73: Roles in Development and Tumor Formation. Molecular Cancer Research 2:7, pages 371-386.
Crossref
Stephanie Si Liu, Rebecca Ching-Yu Leung, Kelvin Yuen-Kwong Chan, Pui-Man Chiu, Annie Nga-Yin Cheung, Kar-Fai Tam, Tong-Yow Ng, Ling-Chui Wong & Hextan Yuen-Sheung Ngan. (2004) p73 Expression Is Associated with the Cellular Radiosensitivity in Cervical Cancer after Radiotherapy. Clinical Cancer Research 10:10, pages 3309-3316.
Crossref
Alessandro Terrinoni, Marco Ranalli, Bruno Cadot, Aida Leta, Giacinto Bagetta, Karen H Vousden & Gerry Melino. (2004) p73-alpha is capable of inducing scotin and ER stress. Oncogene 23:20, pages 3721-3725.
Crossref
Yan-ping Wan, Yi-mou Wu, Cui-ming Zhu, Li-zhi Tan, Ming-jun Yu & Duan-fang Liao. (2003) Binding and interaction of transcriptional regulator human Daxx with adenovirus12 E1B 55 kilodalton oncoprotein. Chinese Journal of Cancer Research 15:4, pages 273-276.
Crossref
Apollonia Tullo, Giuseppe Mastropasqua, Jean Christophe Bourdon, Paola Centonze, Monica Gostissa, Antonio Costanzo, Massimo Levrero, Giannino Del Sal, Cecilia Saccone & Elisabetta Sbisà. (2003) Adenosine deaminase, a key enzyme in DNA precursors control, is a new p73 target. Oncogene 22:54, pages 8738-8748.
Crossref
Tanel Punga & Göran Akusjärvi. (2003) Adenovirus 2 E1B-55K protein relieves p53-mediated transcriptional repression of the survivin and MAP4 promoters. FEBS Letters 552:2-3, pages 214-218.
Crossref
Angelika Waltermann, Natalia N Kartasheva & Matthias Dobbelstein. (2003) Differential regulation of p63 and p73 expression. Oncogene 22:36, pages 5686-5693.
Crossref
Kou Miyazaki, Toshinori Ozaki, Chiaki Kato, Takayuki Hanamoto, Tomoyuki Fujita, Shigemi Irino, Ken-ichi Watanabe, Takahito Nakagawa & Akira Nakagawara. (2003) A novel HECT-type E3 ubiquitin ligase, NEDL2, stabilizes p73 and enhances its transcriptional activity. Biochemical and Biophysical Research Communications 308:1, pages 106-113.
Crossref
Toshinori Ozaki, Ken-ichi Watanabe, Takahito Nakagawa, Kou Miyazaki, Masato Takahashi & Akira Nakagawara. (2003) Function of p73, not of p53, is inhibited by the physical interaction with RACK1 and its inhibitory effect is counteracted by pRB. Oncogene 22:21, pages 3231-3242.
Crossref
Sanjeev Das, Wafik S. El-Deiry & Kumaravel Somasundaram. (2003) Regulation of the p53 Homolog p73 by Adenoviral Oncogene E1A. Journal of Biological Chemistry 278:20, pages 18313-18320.
Crossref
Giulia Fontemaggi, Itai Kela, Ninette Amariglio, Gideon Rechavi, Janakiraman Krishnamurthy, Sabrina Strano, Ada Sacchi, David Givol & Giovanni Blandino. (2002) Identification of Direct p73 Target Genes Combining DNA Microarray and Chromatin Immunoprecipitation Analyses. Journal of Biological Chemistry 277:45, pages 43359-43368.
Crossref
Christian Löber, Claudia Lenz-Stöppler & Matthias Dobbelstein. (2002) Adenovirus E1-transformed cells grow despite the continuous presence of transcriptionally active p53. Journal of General Virology 83:8, pages 2047-2057.
Crossref
Nagy A Habib, Ragai Mitry, Prem Seth, Mohan Kuppuswamy, Konstantin Doronin, Karoly Toth, Peter Krajcsi, Ann E Tollefson & William S M Wold. (2002) Adenovirus replication–competent vectors (KD1, KD3) complement the cytotoxicity and transgene expression from replication-defective vectors (Ad-GFP, Ad-Luc). Cancer Gene Therapy 9:8, pages 651-654.
Crossref
Gerry Melino, Vincenzo De Laurenzi & Karen H. Vousden. (2002) p73: Friend or foe in tumorigenesis. Nature Reviews Cancer 2:8, pages 605-615.
Crossref
Natalia N Kartasheva, Ana Contente, Claudia Lenz-Stöppler, Judith Roth & Matthias Dobbelstein. (2002) p53 induces the expression of its antagonist p73ΔN, establishing an autoregulatory feedback loop. Oncogene 21:31, pages 4715-4727.
Crossref
Kyung-Hwa Kang, Jung-Hee Lee, Keun-Cheol Kim, Seung-Wook Ham, Mie-Young Kim & Kyung Hee Choi. (2002) Induction of p73β by a naphthoquinone analog is mediated by E2F-1 and triggers apoptosis in HeLa cells. FEBS Letters 522:1-3, pages 161-167.
Crossref
Arnab Basu, Keith Meyer, Ratna B. Ray & Ranjit Ray. (2002) Hepatitis C Virus Core Protein Is Necessary for the Maintenance of Immortalized Human Hepatocytes. Virology 298:1, pages 53-62.
Crossref
Muriel Vayssade, Laetitia Faridoni-Laurens, Jean Bénard & Jean-Charles Ahomadegbe. (2002) Expression of p53 -family members and associated target molecules in breast cancer cell lines in response to vincristine treatment. Biochemical Pharmacology 63:9, pages 1609-1617.
Crossref
Jan H. von der ThüsenBart J.M. van VlijmenRob C. HoebenMark M. KockxL.M. HavekesTheo J.C. van BerkelErik A.L. Biessen. (2002) Induction of Atherosclerotic Plaque Rupture in Apolipoprotein E −/− Mice After Adenovirus-Mediated Transfer of p53 . Circulation 105:17, pages 2064-2070.
Crossref
Ken-ichi Watanabe, Toshinori Ozaki, Takahito Nakagawa, Kou Miyazaki, Masato Takahashi, Mitsuchika Hosoda, Syunji Hayashi, Satoru Todo & Akira Nakagawara. (2002) Physical Interaction of p73 with c-Myc and MM1, a c-Myc-binding Protein, and Modulation of the p73 Function. Journal of Biological Chemistry 277:17, pages 15113-15123.
Crossref
Yoon-Jae Song & Mark F. Stinski. (2002) Effect of the human cytomegalovirus IE86 protein on expression of E2F-responsive genes: A DNA microarray analysis. Proceedings of the National Academy of Sciences 99:5, pages 2836-2841.
Crossref
Joseph S. Orlando & David A. Ornelles. (2002) E4orf6 Variants with Separate Abilities To Augment Adenovirus Replication and Direct Nuclear Localization of the E1B 55-Kilodalton Protein. Journal of Virology 76:3, pages 1475-1487.
Crossref
Ricardo Sanchez-Prieto, Victor Javier Sanchez-Arevalo, Joan-Marc Servitja & J Silvio Gutkind. (2002) Regulation of p73 by c-Abl through the p38 MAP kinase pathway. Oncogene 21:6, pages 974-979.
Crossref
Zhen-Hua Xu. (2002) p73β inhibits transcriptional activities of enhancer I and X promoter in hepatitis B virus more efficiently than p73α. World Journal of Gastroenterology 8:6, pages 1094.
Crossref
Ratnam S. Seelan, Meredith Irwin, Petra van der Stoop, Chiping Qian, William G. KaelinJrJr & Wanguo Liu. (2002) The Human p73 Promoter: Characterization and Identification of Functional E2F Binding Sites. Neoplasia 4:3, pages 195-203.
Crossref
Ute M. Moll, Susan Erster & Alex Zaika. (2001) p53, p63 and p73 – solos, alliances and feuds among family members. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1552:2, pages 47-59.
Crossref
Phillip H Gallimore & Andrew S Turnell. (2001) Adenovirus E1A: remodelling the host cell, a life or death experience. Oncogene 20:54, pages 7824-7835.
Crossref
Keun-Cheol Kim, Taek-Seung Kim, Kyung-Hwa Kang & Kyung-Hee Choi. (2001) Amphiphysin IIb-1, a novel splicing variant of amphiphysin II, regulates p73β function through protein-protein interactions. Oncogene 20:46, pages 6689-6699.
Crossref
Birgitt Täuber & Thomas Dobner. (2001) Molecular regulation and biological function of adenovirus early genes: the E4 ORFs. Gene 278:1-2, pages 1-23.
Crossref
Qiang Yu, Ji Hyun La Rose, Hongliang Zhang & Yves Pommier. (2001) Antisense inhibition of Chk2/hCds1 expression attenuates DNA damage-induced S and G2 checkpoints and enhances apoptotic activity in HEK-293 cells. FEBS Letters 505:1, pages 7-12.
Crossref
Laetitia Faridoni-Laurens, Jacques Bosq, François Janot, Muriel Vayssade, Marie-Luce Le Bihan, Mourad Kaghad, Daniel Caput, Jean Bénard & Jean-Charles Ahomadegbe. (2001) P73 expression in basal layers of head and neck squamous epithelium: a role in differentiation and carcinogenesis in concert with p53 and p63?. Oncogene 20:38, pages 5302-5312.
Crossref
Jijie Gu, Rachel M Rubin & Zhi-Min Yuan. (2001) A sequence element of p53 that determines its susceptibility to viral oncoprotein-targeted degradation. Oncogene 20:27, pages 3519-3527.
Crossref
Mohamed Bentires-Alj, Emmanuel Dejardin, Patrick Viatour, Carine Van Lint, Barbara Froesch, John C Reed, Marie-Paule Merville & Vincent Bours. (2001) Inhibition of the NF-κB transcription factor increases Bax expression in cancer cell lines. Oncogene 20:22, pages 2805-2813.
Crossref
Alexander Zaika, Meredith Irwin, Christine Sansome & Ute M. Moll. (2001) Oncogenes Induce and Activate Endogenous p73 Protein. Journal of Biological Chemistry 276:14, pages 11310-11316.
Crossref
Sabrina Strano, Mario Rossi, Giulia Fontemaggi, Eliana Munarriz, Silvia Soddu, Ada Sacchi & Giovanni Blandino. (2001) From p63 to p53 across p73. FEBS Letters 490:3, pages 163-170.
Crossref
Emmanuelle Querido, Megan R. Morisson, Huan Chu-Pham-Dang, Sarah W.-L. Thirlwell, Dominique Boivin & Philip E. Branton. (2001) Identification of Three Functions of the Adenovirus E4orf6 Protein That Mediate p53 Degradation by the E4orf6-E1B55K Complex. Journal of Virology 75:2, pages 699-709.
Crossref
Sabrina Strano, Eliana Munarriz, Mario Rossi, Luisa Castagnoli, Yosef Shaul, Ada Sacchi, Moshe Oren, Marius Sudol, Gianni Cesareni & Giovanni Blandino. (2001) Physical Interaction with Yes-associated Protein Enhances p73 Transcriptional Activity. Journal of Biological Chemistry 276:18, pages 15164-15173.
Crossref
Toni Cathomen & Matthew D. Weitzman. (2000) A Functional Complex of Adenovirus Proteins E1B-55kDa and E4orf6 Is Necessary To Modulate the Expression Level of p53 but Not Its Transcriptional Activity. Journal of Virology 74:23, pages 11407-11412.
Crossref
VINCENZO LAURENZI & GERRY MELINO. (2006) Evolution of Functions within the p53/p63/p73 Family. Annals of the New York Academy of Sciences 926:1, pages 90-100.
Crossref
David R. Schwam, Randy L. Luciano, Shahana S. Mahajan, LaiYee Wong & Angus C. Wilson. (2000) Carboxy Terminus of Human Herpesvirus 8 Latency-Associated Nuclear Antigen Mediates Dimerization, Transcriptional Repression, and Targeting to Nuclear Bodies. Journal of Virology 74:18, pages 8532-8540.
Crossref
Tanel Punga & Göran Akusjärvi. (2000) The adenovirus-2 E1B-55K protein interacts with a mSin3A/histone deacetylase 1 complex. FEBS Letters 476:3, pages 248-252.
Crossref
Michael Nevels, Susanne Rubenwolf, Thilo Spruss, Hans Wolf & Thomas Dobner. (2000) Two Distinct Activities Contribute to the Oncogenic Potential of the Adenovirus Type 5 E4orf6 Protein. Journal of Virology 74:11, pages 5168-5181.
Crossref
Elizabeth Clark, Francisco Santiago, Longwen Deng, Siew yen Chong, Cynthia de la Fuente, Lai Wang, Peng Fu, Dana SteinThomas DennyVenkata Lanka, Fariba Mozafari, Takashi Okamoto & Fatah Kashanchi. (2000) Loss of G 1 /S Checkpoint in Human Immunodeficiency Virus Type 1-Infected Cells Is Associated with a Lack of Cyclin-Dependent Kinase Inhibitor p21/Waf1 . Journal of Virology 74:11, pages 5040-5052.
Crossref
M. LevreroV. De LaurenziA. CostanzoJ. GongJ.Y. WangG. Melino. (2000) The p53/p63/p73 family of transcription factors: overlapping and distinct functions. Journal of Cell Science 113:10, pages 1661-1670.
Crossref
Maria C Marin & William G KaelinJr.Jr.. (2000) p63 and p73: old members of a new family. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1470:3, pages M93-M100.
Crossref
Volkher Scharnhorst, Patrick Dekker, Alex J. van der Eb & Aart G. Jochemsen. (2000) Physical Interaction between Wilms Tumor 1 and p73 Proteins Modulates Their Functions. Journal of Biological Chemistry 275:14, pages 10202-10211.
Crossref
Yasuo Ariumi, Atsushi Kaida, Jye-Yee Lin, Masami Hirota, Osamu Masui, Shoji Yamaoka, Yoichi Taya & Kunitada Shimotohno. (2000) HTLV-1 Tax oncoprotein represses the p53-mediated trans-activation function through coactivator CBP sequestration. Oncogene 19:12, pages 1491-1499.
Crossref
Atsushi Kaida, Yasuo Ariumi, Yoshihide Ueda, Jye-Yee Lin, Makoto Hijikata, Shuntaro Ikawa & Kunitada Shimotohno. (2000) Functional impairment of p73 and p51, the p53-related proteins, by the human T-cell leukemia virus type 1 Tax oncoprotein. Oncogene 19:6, pages 827-830.
Crossref
Dania Alarcon-Vargas, Serge Y Fuchs, Sumitra Deb & Ze'ev Ronai. (2000) p73 transcriptional activity increases upon cooperation between its spliced forms. Oncogene 19:6, pages 831-835.
Crossref
Sandra Wienzek, Judith Roth & Matthias Dobbelstein. (2000) E1B 55-Kilodalton Oncoproteins of Adenovirus Types 5 and 12 Inactivate and Relocalize p53, but Not p51 or p73, and Cooperate with E4orf6 Proteins To Destabilize p53. Journal of Virology 74:1, pages 193-202.
Crossref
Wahiba Oualikene & Bernard Massie. 2000. Cell Engineering. Cell Engineering 80 154 .
Judith Roth & Matthias Dobbelstein. (1999) Failure of viral oncoproteins to target the p53-homologue p51A. Journal of General Virology 80:12, pages 3251-3255.
Crossref
Xinbin Chen. (1999) The p53 family: same response, different signals?. Molecular Medicine Today 5:9, pages 387-392.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.