Advanced search
Publication Cover
Molecular and Cellular Biology Volume 19, 1999 - Issue 6
Submit an article Journal homepage
65
Views
437
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Protein Kinase B/Akt Participates in GLUT4 Translocation by Insulin in L6 Myoblasts

Qinghua Wang1 Programme in Cell Biology, The Hospital for Sick Children, Toronto, OntarioM5G 1X8
,
Romel Somwar1 Programme in Cell Biology, The Hospital for Sick Children, Toronto, OntarioM5G 1X8;2 Department of Biochemistry, The University of Toronto, Toronto, OntarioM5S 1A8
,
Philip J. Bilan1 Programme in Cell Biology, The Hospital for Sick Children, Toronto, OntarioM5G 1X8
,
Zhi Liu1 Programme in Cell Biology, The Hospital for Sick Children, Toronto, OntarioM5G 1X8
,
Jing Jin3 Experimental Therapeutics, Ontario Cancer Institute, Toronto, OntarioM5G 2M9, Canada
,
James R. Woodgett3 Experimental Therapeutics, Ontario Cancer Institute, Toronto, OntarioM5G 2M9, Canada
&
Amira Klip1 Programme in Cell Biology, The Hospital for Sick Children, Toronto, OntarioM5G 1X8;2 Department of Biochemistry, The University of Toronto, Toronto, OntarioM5S 1A8Correspondence[email protected]
 show all
Pages 4008-4018 | Received 05 Nov 1998, Accepted 22 Mar 1999, Published online: 27 Mar 2023

Citations (437)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (18)

Shrijana Shrestha, Vijay Kumar Singh, Sajib Kumar Sarkar, Balasubramanian Shanmugasundaram, Kadirvelu Jeevaratnam & Bidhan Chandra Koner. (2020) Effect of sub-toxic exposure to Malathion on glucose uptake and insulin signaling in L6 myoblast derived myotubes. Drug and Chemical Toxicology 43:6, pages 663-670.
Read now
Alexander W. Shingleton. (2010) The regulation of organ size in Drosophila . Organogenesis 6:2, pages 76-87.
Read now
Phillip J. Bilan, Victor Samokhvalov, Alexandra Koshkina, Jonathan D. Schertzer, M. Constantine Samaan & Amira Klip. (2009) Direct and macrophage-mediated actions of fatty acids causing insulin resistance in muscle cells. Archives of Physiology and Biochemistry 115:4, pages 176-190.
Read now
Karen O'Brien, Hiroko Sekimoto, Charlotte Boney & Maureen Malee. (2008) Effect of fetal dexamethasone exposure on the development of adult insulin sensitivity in a rat model. The Journal of Maternal-Fetal & Neonatal Medicine 21:9, pages 623-628.
Read now
Takeshi Yoshizaki, Takeshi Imamura, Jennie L. Babendure, Juu-Chin Lu, Noriyuki Sonoda & Jerrold M. Olefsky. (2007) Myosin 5a Is an Insulin-Stimulated Akt2 (Protein Kinase Bβ) Substrate Modulating GLUT4 Vesicle Translocation. Molecular and Cellular Biology 27:14, pages 5172-5183.
Read now
Weizhou Zhang, Cong S. Zong, Ulrich Hermanto, Pablo Lopez-Bergami, Ze'ev Ronai & Lu-Hai Wang. (2006) RACK1 Recruits STAT3 Specifically to Insulin and Insulin-Like Growth Factor 1 Receptors for Activation, Which Is Important for Regulating Anchorage-Independent Growth. Molecular and Cellular Biology 26:2, pages 413-424.
Read now
Nadeeja Wijesekara, Daniel Konrad, Mohamed Eweida, Craig Jefferies, Nicole Liadis, Adria Giacca, Mike Crackower, Akira Suzuki, Tak W. Mak, C. Ronald Kahn, Amira Klip & Minna Woo. (2005) Muscle-Specific Pten Deletion Protects against Insulin Resistance and Diabetes. Molecular and Cellular Biology 25:3, pages 1135-1145.
Read now
Satoshi Ugi, Takeshi Imamura, Hiroshi Maegawa, Katsuya Egawa, Takeshi Yoshizaki, Kun Shi, Toshiyuki Obata, Yousuke Ebina, Atsunori Kashiwagi & Jerrold M. Olefsky. (2004) Protein Phosphatase 2A Negatively Regulates Insulin's Metabolic Signaling Pathway by Inhibiting Akt (Protein Kinase B) Activity in 3T3-L1 Adipocytes. Molecular and Cellular Biology 24:19, pages 8778-8789.
Read now
Nish Patel, Assaf Rudich, Zayna A. Khayat, Rami Garg & Amira Klip. (2003) Intracellular Segregation of Phosphatidylinositol-3,4,5-Trisphosphate by Insulin-Dependent Actin Remodeling in L6 Skeletal Muscle Cells. Molecular and Cellular Biology 23:13, pages 4611-4626.
Read now
Miri Stolovich, Hua Tang, Eran Hornstein, Galit Levy, Ruth Cohen, Sun Sik Bae, Morris J. Birnbaum & Oded Meyuhas. (2002) Transduction of Growth or Mitogenic Signals into Translational Activation of TOP mRNAs Is Fully Reliant on the Phosphatidylinositol 3-Kinase-Mediated Pathway but Requires neither S6K1 nor rpS6 Phosphorylation. Molecular and Cellular Biology 22:23, pages 8101-8113.
Read now
Janet Farhang-Fallah, Varinder K. Randhawa, Anjaruwee Nimnual, Amira Klip, Dafna Bar-Sagi & Maria Rozakis-Adcock. (2002) The Pleckstrin Homology (PH) Domain-Interacting Protein Couples the Insulin Receptor Substrate 1 PH Domain to Insulin Signaling Pathways Leading to Mitogenesis and GLUT4 Translocation. Molecular and Cellular Biology 22:20, pages 7325-7336.
Read now
Tetsuo Shioi, Julie R. McMullen, Peter M. Kang, Pamela S. Douglas, Toshiyuki Obata, Thomas F. Franke, Lewis C. Cantley & Seigo Izumo. (2002) Akt/Protein Kinase B Promotes Organ Growth in Transgenic Mice. Molecular and Cellular Biology 22:8, pages 2799-2809.
Read now
Hua Tang, Eran Hornstein, Miri Stolovich, Galit Levy, Mark Livingstone, Dennis Templeton, Joseph Avruch & Oded Meyuhas. (2001) Amino Acid-Induced Translation of TOP mRNAs Is Fully Dependent on Phosphatidylinositol 3-Kinase-Mediated Signaling, Is Partially Inhibited by Rapamycin, and Is Independent of S6K1 and rpS6 Phosphorylation. Molecular and Cellular Biology 21:24, pages 8671-8683.
Read now
Atsuko Takano, Isao Usui, Tetsuro Haruta, Junko Kawahara, Tatsuhito Uno, Minoru Iwata & Masashi Kobayashi. (2001) Mammalian Target of Rapamycin Pathway Regulates Insulin Signaling via Subcellular Redistribution of Insulin Receptor Substrate 1 and Integrates Nutritional Signals and Metabolic Signals of Insulin. Molecular and Cellular Biology 21:15, pages 5050-5062.
Read now
Tsutomu Wada, Toshiyasu Sasaoka, Makoto Funaki, Hiroyuki Hori, Shihou Murakami, Manabu Ishiki, Tetsuro Haruta, Tomoichiro Asano, Wataru Ogawa, Hajime Ishihara & Masashi Kobayashi. (2001) Overexpression of SH2-Containing Inositol Phosphatase 2 Results in Negative Regulation of Insulin-Induced Metabolic Actions in 3T3-L1 Adipocytes via Its 5′-Phosphatase Catalytic Activity. Molecular and Cellular Biology 21:5, pages 1633-1646.
Read now
Tetsuharu Shinjyo, Ryoko Kuribara, Takeshi Inukai, Hajime Hosoi, Taisei Kinoshita, Atsushi Miyajima, Peter J. Houghton, A. Thomas Look, Keiya Ozawa & Toshiya Inaba. (2001) Downregulation of Bim, a Proapoptotic Relative of Bcl-2, Is a Pivotal Step in Cytokine-Initiated Survival Signaling in Murine Hematopoietic Progenitors. Molecular and Cellular Biology 21:3, pages 854-864.
Read now
Michelle M. Hill, Sharon F. Clark, David F. Tucker, Morris J. Birnbaum, David E. James & S. Lance Macaulay. (1999) A Role for Protein Kinase Bβ/Akt2 in Insulin-Stimulated GLUT4 Translocation in Adipocytes. Molecular and Cellular Biology 19:11, pages 7771-7781.
Read now
Armelle A. Troussard, Clara Tan, T. Nathan Yoganathan & Shoukat Dedhar. (1999) Cell-Extracellular Matrix Interactions Stimulate the AP-1 Transcription Factor in an Integrin-Linked Kinase- and Glycogen Synthase Kinase 3-Dependent Manner. Molecular and Cellular Biology 19:11, pages 7420-7427.
Read now

Articles from other publishers (419)

Mayuri Khandelwal, Gokul Krishna, Zhe Ying & Fernando Gomez-Pinilla. (2023) Liver acts as a metabolic gate for the traumatic brain injury pathology: Protective action of thyroid hormone. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1869:6, pages 166728.
Crossref
Escarlata Fernández-Puente, Eva Martín-Prieto, Carlos Manuel Márquez & Jesús Palomero. (2023) Effect of RONS-Induced Intracellular Redox Homeostasis in 6-NBDG/Glucose Uptake in C2C12 Myotubes and Single Isolated Skeletal Muscle Fibres. International Journal of Molecular Sciences 24:9, pages 8082.
Crossref
Jessica Laiman, Yen-Jung Hsu, Julie Loh, Wei-Chun Tang, Mei-Chun Chuang, Hui-Kang Liu, Wei-Shun Yang, Bi-Chang Chen, Lee-Ming Chuang, Yi-Cheng Chang & Ya-Wen Liu. (2023) GSK3α phosphorylates dynamin-2 to promote GLUT4 endocytosis in muscle cells. Journal of Cell Biology 222:2.
Crossref
Paola Llanos & Jesus Palomero. (2022) Reactive Oxygen and Nitrogen Species (RONS) and Cytokines—Myokines Involved in Glucose Uptake and Insulin Resistance in Skeletal Muscle. Cells 11:24, pages 4008.
Crossref
Fulvia Draicchio, Volker Behrends, Neale A. Tillin, Nicholas M. Hurren, Lykke Sylow & Richard Mackenzie. (2022) Involvement of the extracellular matrix and integrin signalling proteins in skeletal muscle glucose uptake. The Journal of Physiology 600:20, pages 4393-4408.
Crossref
Gagandeep Mann, Michael C. Riddell & Olasunkanmi A. J. Adegoke. (2022) Effects of Acute Muscle Contraction on the Key Molecules in Insulin and Akt Signaling in Skeletal Muscle in Health and in Insulin Resistant States. Diabetology 3:3, pages 423-446.
Crossref
Ben Stocks & Juleen R Zierath. (2022) Post-translational Modifications: The Signals at the Intersection of Exercise, Glucose Uptake, and Insulin Sensitivity. Endocrine Reviews 43:4, pages 654-677.
Crossref
Jinhee Hwang & Debbie C. Thurmond. (2022) Exocytosis Proteins: Typical and Atypical Mechanisms of Action in Skeletal Muscle. Frontiers in Endocrinology 13.
Crossref
Sasa Liu, Juan Zhang, Rui Qi, Bangli Deng, Yuge Ni, Chang Zhang & Wenyan Niu. (2022) CaMKII and Kalirin, a Rac1-GEF, regulate Akt phosphorylation involved in contraction-induced glucose uptake in skeletal muscle cells. Biochemical and Biophysical Research Communications 610, pages 170-175.
Crossref
Sangeetha S. B. Singh & K. Neelakanteshwar Patil. (2022) trans ‐ferulic acid attenuates hyperglycemia‐induced oxidative stress and modulates glucose metabolism by activating AMPK signaling pathway in vitro . Journal of Food Biochemistry 46:2.
Crossref
Renée N. O. Silva, Ricardo P. Llanos, Rosangela A. S. Eichler, Thiago B. Oliveira, Fábio C. Gozzo, William T. Festuccia & Emer S. Ferro. (2021) New Intracellular Peptide Derived from Hemoglobin Alpha Chain Induces Glucose Uptake and Reduces Blood Glycemia. Pharmaceutics 13:12, pages 2175.
Crossref
Won-Il Choi, Jae-Hyun Yoon, Seo-Hyun Choi, Bu-Nam Jeon, Hail Kim & Man-Wook Hur. (2021) Proto-oncoprotein Zbtb7c and SIRT1 repression: implications in high-fat diet-induced and age-dependent obesity. Experimental & Molecular Medicine 53:5, pages 917-932.
Crossref
Man Mohan Shrestha, Chun-Yan Lim, Xuezhi Bi, Robert C. Robinson & Weiping Han. (2021) Tmod3 Phosphorylation Mediates AMPK-Dependent GLUT4 Plasma Membrane Insertion in Myoblasts. Frontiers in Endocrinology 12.
Crossref
Khairul Samuki, Mia Setiawati, Dedi Jusadi & Muhammad Agus Suprayudi. (2020) The evaluation of α‐Lipoic acid supplementation in diet on the growth performance of giant gourami ( Osphronemus goramy ) juvenile . Aquaculture Research 52:4, pages 1538-1547.
Crossref
Lykke Sylow, Victoria L. Tokarz, Erik A. Richter & Amira Klip. (2021) The many actions of insulin in skeletal muscle, the paramount tissue determining glycemia. Cell Metabolism 33:4, pages 758-780.
Crossref
Martin Alejandro Pavarotti, Victoria Tokarz, Scott Frendo-Cumbo, Philip J. Bilan, Zhi Liu, Emilia Zanni-Ruiz, Luis Segundo Mayorga & Amira Klip. (2021) Complexin-2 redistributes to the membrane of muscle cells in response to insulin and contributes to GLUT4 translocation. Biochemical Journal 478:2, pages 407-422.
Crossref
Ankit Chauhan, Dhananjay Kumar Sah, Neeraj Kumari, Namita Kalra, Ravi Soni & Anant Narayan Bhatt. (2021) PTEN inhibitor bpV(HOpic) confers protection against ionizing radiation. Scientific Reports 11:1.
Crossref
Stewart W.C. Masson, Brie Sorrenson, Peter R. Shepherd & Troy L. Merry. (2020) β-catenin regulates muscle glucose transport via actin remodelling and M-cadherin binding. Molecular Metabolism 42, pages 101091.
Crossref
Catheryn W. Gray & Adelle C.F. Coster. (2020) From insulin to Akt: Time delays and dominant processes. Journal of Theoretical Biology 507, pages 110454.
Crossref
Mei WangShan-Quan ChangYu-Shan TianGe-Qiang ZhangJin Qi. (2020) Zengye Decoction Ameliorates Insulin Resistance by Promoting Glucose Uptake. Rejuvenation Research 23:5, pages 367-376.
Crossref
Shu-Jing Wu, Yi-Jou Tung & Lean-Teik Ng. (2020) Anti-diabetic effects of Grifola frondosa bioactive compound and its related molecular signaling pathways in palmitate-induced C2C12 cells. Journal of Ethnopharmacology 260, pages 112962.
Crossref
Gwyn W. Gould, Frances M. Brodsky & Nia J. Bryant. (2020) Building GLUT4 Vesicles: CHC22 Clathrin’s Human Touch. Trends in Cell Biology 30:9, pages 705-719.
Crossref
Karla E. Merz & Debbie C. Thurmond. 2011. Comprehensive Physiology. Comprehensive Physiology 785 809 .
Unai Galicia-Garcia, Shifa Jebari, Asier Larrea-Sebal, Kepa B. Uribe, Haziq Siddiqi, Helena Ostolaza, Asier Benito-Vicente & César Martín. (2020) Statin Treatment-Induced Development of Type 2 Diabetes: From Clinical Evidence to Mechanistic Insights. International Journal of Molecular Sciences 21:13, pages 4725.
Crossref
Xia Yi, Jianyun Liu, Ping Wu, Ying Gong, Xiaoyuan Xu & Weidong Li. (2019) The whole transcriptional profiling of cellular metabolism during adipogenesis from hMSCs. Journal of Cellular Physiology 235:1, pages 349-363.
Crossref
Zhifa Wang, Yunya Wang, Yuehu Han, Qiang Yin, Sheng Hu, Ting Zhao, Tao Chen, Heng Ma & Chunhu Gu. (2019) Akt is a critical node of acute myocardial insulin resistance and cardiac dysfunction after cardiopulmonary bypass. Life Sciences 234, pages 116734.
Crossref
Ping Zhao, Di Tian, Guanjun Song, Qian Ming, Jia Liu, Jinhua Shen, Qing-Hua Liu & Xinzhou Yang. (2019) Neferine Promotes GLUT4 Expression and Fusion With the Plasma Membrane to Induce Glucose Uptake in L6 Cells. Frontiers in Pharmacology 10.
Crossref
James Casella-Mariolo, Lidia Castagneto-Gissey, Giulia Angelini, Andrea Zoli, Pierluigi Marini, Stefan R. Bornstein, Dimitri J. Pournaras, Francesco Rubino, Carel W. le Roux, Geltrude Mingrone & Giovanni Casella. (2019) Simulation of gastric bypass effects on glucose metabolism and non-alcoholic fatty liver disease with the Sleeveballoon device. EBioMedicine 46, pages 452-462.
Crossref
Maëva Elzaiat, Laetitia Herman, Bérangère Legois, Thibaut Léger, Anne-Laure Todeschini & Reiner A. Veitia. (2019) High-throughput Exploration of the Network Dependent on AKT1 in Mouse Ovarian Granulosa Cells. Molecular & Cellular Proteomics 18:7, pages 1307-1319.
Crossref
Maëva Elzaiat, Laetitia Herman, Bérangère Legois, Thibaut Léger, Anne-Laure Todeschini & Reiner A. Veitia. (2019) High-throughput Exploration of the Network Dependent on AKT1 in Mouse Ovarian Granulosa Cells. Molecular & Cellular Proteomics 18:7, pages 1307-1319.
Crossref
Gerda M. Sanvee, Miljenko V. Panajatovic, Jamal Bouitbir & Stephan Krähenbühl. (2019) Mechanisms of insulin resistance by simvastatin in C2C12 myotubes and in mouse skeletal muscle. Biochemical Pharmacology 164, pages 23-33.
Crossref
Siba Shanak, Bashar Saad & Hilal Zaid. (2019) Metabolic and Epigenetic Action Mechanisms of Antidiabetic Medicinal Plants. Evidence-Based Complementary and Alternative Medicine 2019, pages 1-18.
Crossref
Catheryn W. Gray & Adelle C. F. Coster. (2018) Crosstalk in transition: the translocation of Akt. Journal of Mathematical Biology 78:4, pages 919-942.
Crossref
Cory M. Dungan, Bradley S. Gordon & David L. Williamson. (2019) Acute treadmill exercise discriminately improves the skeletal muscle insulin-stimulated growth signaling responses in mice lacking REDD1. Physiological Reports 7:4, pages e14011.
Crossref
Elita Montanari, Arianna Gennari, Maria Pelliccia, Lucio Manzi, Roberto Donno, Neil J. Oldham, Andrew MacDonald & Nicola Tirelli. (2018) Tyrosinase-Mediated Bioconjugation. A Versatile Approach to Chimeric Macromolecules. Bioconjugate Chemistry 29:8, pages 2550-2560.
Crossref
Victoria L. Tokarz, Patrick E. MacDonald & Amira Klip. (2018) The cell biology of systemic insulin function. Journal of Cell Biology 217:7, pages 2273-2289.
Crossref
Iveta Nedvedova, David Kolar, Barbara Elsnicova, Daniela Hornikova, Jiri Novotny, Martin Kalous, Michal Pravenec, Jan Neckar, Frantisek Kolar & Jitka M. Zurmanova. (2018) Mitochondrial genome modulates myocardial Akt/Glut/HK salvage pathway in spontaneously hypertensive rats adapted to chronic hypoxia. Physiological Genomics 50:7, pages 532-541.
Crossref
Haeun KimKae Won ChoJeongho JeongKibeum ParkYungsun RyuKnowledge Mudhibadhi MoyoHyun Kyung KimGwang-Woong Go. (2018) Red Pepper ( Capsicum annuum L.) Seed Extract Decreased Hepatic Gluconeogenesis and Increased Muscle Glucose Uptake In Vitro . Journal of Medicinal Food 21:7, pages 665-671.
Crossref
Anita A. Wasik & Sanna Lehtonen. (2018) Glucose Transporters in Diabetic Kidney Disease—Friends or Foes?. Frontiers in Endocrinology 9.
Crossref
Huogen Lu, Elena Bogdanovic, Zhiwen Yu, Charles Cho, Lijiang Liu, Karen Ho, June Guo, Lucy S N Yeung, Reiner Lehmann, Harinder S Hundal, Adria Giacca & I George Fantus. (2018) Combined Hyperglycemia- and Hyperinsulinemia-Induced Insulin Resistance in Adipocytes Is Associated With Dual Signaling Defects Mediated by PKC-ζ. Endocrinology 159:4, pages 1658-1677.
Crossref
D.G. Semaan, J.O. Igoli, L. Young, A.I. Gray, E.G. Rowan & E. Marrero. (2018) In vitro anti-diabetic effect of flavonoids and pheophytins from Allophylus cominia Sw . on the glucose uptake assays by HepG2, L6, 3T3-L1 and fat accumulation in 3T3-L1 adipocytes. Journal of Ethnopharmacology 216, pages 8-17.
Crossref
Ruiting Lin, Siyuan Xia, Changliang Shan, Dong Chen, Yijie Liu, Xue Gao, Mei Wang, Hee-Bum Kang, Yaozhu Pan, Shuangping Liu, Young Rock Chung, Omar Abdel-Wahab, Taha Merghoub, Michael Rossi, Ragini R. Kudchadkar, David H. Lawson, Fadlo R. Khuri, Sagar Lonial & Jing Chen. (2018) The Dietary Supplement Chondroitin-4-Sulfate Exhibits Oncogene-Specific Pro-tumor Effects on BRAF V600E Melanoma Cells. Molecular Cell 69:6, pages 923-937.e8.
Crossref
Nicolas J. Pillon, Scott Frendo-Cumbo, Maya R. Jacobson, Zhi Liu, Paul L. Milligan, Hai Hoang Bui, Juleen R. Zierath, Philip J. Bilan, Joseph T. Brozinick & Amira Klip. (2018) Sphingolipid changes do not underlie fatty acid-evoked GLUT4 insulin resistance nor inflammation signals in muscle cells[S]. Journal of Lipid Research 59:7, pages 1148-1163.
Crossref
Maiko Ogiwara, Wakana Ota, Takafumi Mizushige, Ryuhei Kanamoto & Kousaku Ohinata. (2018) Enzymatic digest of whey protein and wheylin-1, a dipeptide released in the digest, increase insulin sensitivity in an Akt phosphorylation-dependent manner. Food & Function 9:9, pages 4635-4641.
Crossref
Javier R. Jaldin-Fincati, Philip J. Bilan & Amira Klip. 2018. Glucose Transport. Glucose Transport 175 192 .
Yunfang Li, Ping Zhao, Yu Chen, Yanze Fu, Kuan Shi, Liu Liu, Hui Liu, Mingrui Xiong, Qing-Hua Liu, Guangzhong Yang & Yuxiu Xiao. (2017) Depsidone and xanthones from Garcinia xanthochymus with hypoglycemic activity and the mechanism of promoting glucose uptake in L6 myotubes. Bioorganic & Medicinal Chemistry 25:24, pages 6605-6613.
Crossref
Atsuyoshi Nishina, Masaya Itagaki, Daisuke Sato, Hirokazu Kimura, Yasuaki Hirai, Nyunt Phay & Makoto Makishima. (2017) The Rosiglitazone-Like Effects of Vitexilactone, a Constituent from Vitex trifolia L. in 3T3-L1 Preadipocytes. Molecules 22:11, pages 2030.
Crossref
Shan Gao, Qing Guo, Chengguang Qin, Rui Shang & Zesheng Zhang. (2017) Sea Buckthorn Fruit Oil Extract Alleviates Insulin Resistance through the PI3K/Akt Signaling Pathway in Type 2 Diabetes Mellitus Cells and Rats. Journal of Agricultural and Food Chemistry 65:7, pages 1328-1336.
Crossref
Xiaoxu Zhou, Ping Shentu & Yingke Xu. (2017) Spatiotemporal Regulators for Insulin-Stimulated GLUT4 Vesicle Exocytosis. Journal of Diabetes Research 2017, pages 1-9.
Crossref
Masayo Iwasa & Wataru Aoi. 2017. Dairy in Human Health and Disease Across the Lifespan. Dairy in Human Health and Disease Across the Lifespan 183 195 .
Bashar Saad, Hilal Zaid, Siba Shanak & Sleman KadanBashar Saad, Hilal Zaid, Siba Shanak & Sleman Kadan. 2017. Anti-diabetes and Anti-obesity Medicinal Plants and Phytochemicals. Anti-diabetes and Anti-obesity Medicinal Plants and Phytochemicals 175 213 .
Ki-Ho Lee, Kyung-Jin Jo, Ju-Young Kim, Haing-Woon Baik & Seong-Kyu Lee. (2016) 17Beta-estradiol Stimulates Glucose Uptake Through Estrogen Receptor and AMP-activated Protein Kinase Activation in C2C12 Myotubes. The Korean Journal of Obesity 25:4, pages 190-196.
Crossref
Sayak Bhattacharya, Kevin E. McElhanon, Liubov V. Gushchina & Noah Weisleder. (2016) Role of phosphatidylinositol-4,5-bisphosphate 3-kinase signaling in vesicular trafficking. Life Sciences 167, pages 39-45.
Crossref
Natasha Chaudhary, Eva Gonzalez, Sung-Hee Chang, Fuqiang Geng, Shahin Rafii, Nasser K. Altorki & Timothy E. McGraw. (2016) Adenovirus Protein E4-ORF1 Activation of PI3 Kinase Reveals Differential Regulation of Downstream Effector Pathways in Adipocytes. Cell Reports 17:12, pages 3305-3318.
Crossref
Nagendra Yaluri, Shalem Modi & Tarja Kokkola. (2016) Simvastatin induces insulin resistance in L6 skeletal muscle myotubes by suppressing insulin signaling, GLUT4 expression and GSK-3β phosphorylation. Biochemical and Biophysical Research Communications 480:2, pages 194-200.
Crossref
Akira Takaguri, Saya Inoue, Takashi Kubo & Kumi Satoh. (2016) AMPK activation by prolonged stimulation with interleukin-1β contributes to the promotion of GLUT4 translocation in skeletal muscle cells. Cell Biology International 40:11, pages 1204-1211.
Crossref
Sheida Torabi & Nancy M DiMarco. (2016) Original Research: Polyphenols extracted from grape powder induce lipogenesis and glucose uptake during differentiation of murine preadipocytes. Experimental Biology and Medicine 241:16, pages 1776-1785.
Crossref
Tad E. Eichler, Brian Becknell, Robert S. Easterling, Susan E. Ingraham, Daniel M. Cohen, Andrew L. Schwaderer, David S. Hains, Birong Li, Ariel Cohen, Jackie Metheny, Susheela Tridandapani & John David Spencer. (2016) Insulin and the phosphatidylinositol 3-kinase signaling pathway regulate Ribonuclease 7 expression in the human urinary tract. Kidney International 90:3, pages 568-579.
Crossref
Wei-Lin Huang, Zhongyou Li, Ting-Yu Lin, Sheng-Wen Wang, Fang-Ju Wu & Ching-Wei Luo. (2016) Thyrostimulin-TSHR signaling promotes the proliferation of NIH:OVCAR-3 ovarian cancer cells via trans-regulation of the EGFR pathway. Scientific Reports 6:1.
Crossref
Catheryn W. Gray & Adelle C.F. Coster. (2016) The Akt switch model: Is location sufficient?. Journal of Theoretical Biology 398, pages 103-111.
Crossref
Atul S. Deshmukh. (2016) Insulin-stimulated glucose uptake in healthy and insulin-resistant skeletal muscle. Hormone Molecular Biology and Clinical Investigation 26:1, pages 13-24.
Crossref
Nicholas P. Gannon & Roger A. Vaughan. (2015) Leucine-induced anabolic-catabolism: two sides of the same coin. Amino Acids 48:2, pages 321-336.
Crossref
Mahmoud Balbaa, Marwa El-Zeftawy, Doaa Ghareeb, Nabil Taha & Abdel Wahab Mandour. (2016) Nigella sativa Relieves the Altered Insulin Receptor Signaling in Streptozotocin-Induced Diabetic Rats Fed with a High-Fat Diet . Oxidative Medicine and Cellular Longevity 2016, pages 1-16.
Crossref
Tatsuro Minami, Kimio Satoh, Masamichi Nogi, Shun Kudo, Satoshi Miyata, Shin-ichi Tanaka & Hiroaki Shimokawa. (2016) Statins up-regulate SmgGDS through β1-integrin/Akt1 pathway in endothelial cells. Cardiovascular Research 109:1, pages 151-161.
Crossref
Sora Han, Jeong Su Park, Sunyi Lee, Ae Lee Jeong, Ki Sook Oh, Hye In Ka, Hyun-Ji Choi, Woo-Chan Son, Won-Young Lee, Suk Joong Oh, Jong-Seok Lim, Myeong-Sok Lee & Young Yang. (2016) CTRP1 protects against diet-induced hyperglycemia by enhancing glycolysis and fatty acid oxidation. The Journal of Nutritional Biochemistry 27, pages 43-52.
Crossref
Anna M. Mancha-Ramirez & Thomas J. Slaga. 2016. Anti-inflammatory Nutraceuticals and Chronic Diseases. Anti-inflammatory Nutraceuticals and Chronic Diseases 75 96 .
Cynthia T. Luk, Stephanie A. Schroer & Minna Woo. 2016. PTEN. PTEN 75 91 .
Bjorn T. Tam, Xiao M. Pei, Benjamin Y. Yung, Shea P. Yip, Lawrence W. Chan, Cesar S. Wong & Parco M. Siu. (2015) Unacylated ghrelin restores insulin and autophagic signaling in skeletal muscle of diabetic mice. Pflügers Archiv - European Journal of Physiology 467:12, pages 2555-2569.
Crossref
FENG GAO, LIUMENG JIAN, MOHAMMAD ISHRAQ ZAFAR, WEN DU, QIN CAI, RAJA ADEEL SHAFQAT & FURONG LU. (2015) 4-Hydroxyisoleucine improves insulin resistance in HepG2 cells by decreasing TNF-α and regulating the expression of insulin signal transduction proteins. Molecular Medicine Reports 12:5, pages 6555-6560.
Crossref
Dae Hyun Kim, Min Hi Park, Ki Wung Chung, Min Jo Kim, Daeui Park, Bonggi Lee, Eun Kyeong Lee, Yeon Ja Choi, Nam Deuk Kim, Byung Pal Yu & Hae Young Chung. (2015) Suppression of FoxO6 by lipopolysaccharide in aged rat liver. Oncotarget 6:33, pages 34143-34157.
Crossref
Michael Caruso, Xiangmin Zhang, Danjun Ma, Zhao Yang, Yue Qi & Zhengping Yi. (2015) Novel Endogenous, Insulin-Stimulated Akt2 Protein Interaction Partners in L6 Myoblasts. PLOS ONE 10:10, pages e0140255.
Crossref
Cesar Osorio-Fuentealba & Amira Klip. (2015) Dissecting signalling by individual Akt/PKB isoforms, three steps at once. Biochemical Journal 470:2, pages e13-e16.
Crossref
Lei Li, Jing Xue, Hongyan Li, Jian Ding, Yanyun Wang & Xietong Wang. (2015) Over-nutrient environment during both prenatal and postnatal development increases severity of islet injury, hyperglycemia, and metabolic disorders in the offspring. Journal of Physiology and Biochemistry 71:3, pages 391-403.
Crossref
Christina Leibrock, Michael Hierlmeier, Undine E. Lang & Florian Lang. (2015) Subtle Impact of Akt1 and Akt3 on Exploratory Behavior in Gene Targeted Mice. Zeitschrift für Psychologie 223:3, pages 173-180.
Crossref
Yoo Kim, Daeyoung Kim, Deborah J. Good & Yeonhwa Park. (2015) Effects of Postweaning Administration of Conjugated Linoleic Acid on Development of Obesity in Nescient Basic Helix–Loop–Helix 2 Knockout Mice. Journal of Agricultural and Food Chemistry 63:21, pages 5212-5223.
Crossref
Rajeshwari Meli, Petronela Weisová & Friedrich Propst. (2015) Repulsive Axon Guidance by Draxin Is Mediated by Protein Kinase B (Akt), Glycogen Synthase Kinase-3β (GSK-3β) and Microtubule-Associated Protein 1B. PLOS ONE 10:3, pages e0119524.
Crossref
Lin Xia, Zhongqiu Wang, Ying Zhang, Xiao Yang, Yibei Zhan, Rui Cheng, Shiming Wang & Jianfa Zhang. (2015) Reciprocal regulation of insulin and plasma 5′-AMP in glucose homeostasis in mice. Journal of Endocrinology 224:3, pages 225-234.
Crossref
D. M. Stringer, P. Zahradka & C. G. Taylor. (2015) Glucose transporters: cellular links to hyperglycemia in insulin resistance and diabetes. Nutrition Reviews 73:3, pages 140-154.
Crossref
Chen-Yu Chen, Fu-Yu Chiu, Yenshou Lin, Wei-Jan Huang, Po-Shiuan Hsieh & Feng-Lin Hsu. (2015) Chemical Constituents Analysis and Antidiabetic Activity Validation of Four Fern Species from Taiwan. International Journal of Molecular Sciences 16:2, pages 2497-2516.
Crossref
Chun-Yan Lim, Xuezhi Bi, Donghai Wu, Jae Bum Kim, Peter W. Gunning, Wanjin Hong & Weiping Han. (2015) Tropomodulin3 is a novel Akt2 effector regulating insulin-stimulated GLUT4 exocytosis through cortical actin remodeling. Nature Communications 6:1.
Crossref
QI ZHANG, YINGYING TAN, NAN ZHANG & FANRONG YAO. (2015) Polydatin supplementation ameliorates diet-induced development of insulin resistance and hepatic steatosis in rats. Molecular Medicine Reports 11:1, pages 603-610.
Crossref
Tuomas A. Tolvanen, Surjya Naryan Dash, Zydrune Polianskyte-Prause, Vincent Dumont & Sanna Lehtonen. (2015) Lack of CD2AP disrupts Glut4 trafficking and attenuates glucose uptake in podocytes. Journal of Cell Science.
Crossref
Tatsuhiro Ayabe, Takafumi Mizushige, Wakana Ota, Fuminori Kawabata, Kohsuke Hayamizu, Li Han, Tomoko Tsuji, Ryuhei Kanamoto & Kousaku Ohinata. (2015) A novel Alaska pollack-derived peptide, which increases glucose uptake in skeletal muscle cells, lowers the blood glucose level in diabetic mice. Food & Function 6:8, pages 2749-2757.
Crossref
Nicholas P. Gannon, Carole A. Conn & Roger A. Vaughan. (2015) Dietary stimulators of GLUT4 expression and translocation in skeletal muscle: A mini-review. Molecular Nutrition & Food Research 59:1, pages 48-64.
Crossref
Pablo Garrido, Fernando G. Osorio, Javier Morán, Estefanía Cabello, Ana Alonso, José M.P. Freije & Celestino González. (2015) Loss of GLUT4 Induces Metabolic Reprogramming and Impairs Viability of Breast Cancer Cells. Journal of Cellular Physiology 230:1, pages 191-198.
Crossref
Chandan Kumar Maurya, Rohit Singh, Natasha Jaiswal, K. Venkateswarlu, Tadigoppula Narender & Akhilesh Kumar Tamrakar. (2014) 4-Hydroxyisoleucine ameliorates fatty acid-induced insulin resistance and inflammatory response in skeletal muscle cells. Molecular and Cellular Endocrinology 395:1-2, pages 51-60.
Crossref
Danielle Camer, Yinghua Yu, Alexander Szabo & Xu-Feng Huang. (2014) The molecular mechanisms underpinning the therapeutic properties of oleanolic acid, its isomer and derivatives for type 2 diabetes and associated complications. Molecular Nutrition & Food Research 58:8, pages 1750-1759.
Crossref
Wuyi Liu & Jingpeng Zhao. (2014) Insights into the molecular mechanism of glucose metabolism regulation under stress in chicken skeletal muscle tissues. Saudi Journal of Biological Sciences 21:3, pages 197-203.
Crossref
Long Zhao, Hui Chen, Yi-Qun Zhan, Chang-Yan Li, Chang-Hui Ge, Jian-Hong Zhang, Xiao-Hui Wang, Miao Yu & Xiao-Ming Yang. (2014) Serine 249 phosphorylation by ATM protein kinase regulates hepatocyte nuclear factor-1α transactivation. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1839:7, pages 604-620.
Crossref
Júlia M. Santos, Shikha Tewari & Sandra A. Benite-Ribeiro. (2014) The effect of exercise on epigenetic modifications of PGC1: The impact on type 2 diabetes. Medical Hypotheses 82:6, pages 748-753.
Crossref
Amira Klip, Yi Sun, Tim Ting Chiu & Kevin P. Foley. (2014) Signal transduction meets vesicle traffic: the software and hardware of GLUT4 translocation. American Journal of Physiology-Cell Physiology 306:10, pages C879-C886.
Crossref
Anusorn Lungkaphin, Phatchawan Arjinajarn, Anchalee Pongchaidecha, Chutima Srimaroeng, Lisa Chatsudthipong & Varanuj Chatsudthipong. (2014) Impaired Insulin Signaling Affects Renal Organic Anion Transporter 3 (Oat3) Function in Streptozotocin-Induced Diabetic Rats. PLoS ONE 9:5, pages e96236.
Crossref
Danielle N. Miranda, Dawn K. Coletta, Lawrence J. Mandarino & Gabriel Q. Shaibi. (2014) Increases in insulin sensitivity among obese youth are associated with gene expression changes in whole blood. Obesity 22:5, pages 1337-1344.
Crossref
J. D. Burke, L. C. Platanias & E. N. Fish. (2014) Beta Interferon Regulation of Glucose Metabolism Is PI3K/Akt Dependent and Important for Antiviral Activity against Coxsackievirus B3. Journal of Virology 88:6, pages 3485-3495.
Crossref
Lykke Sylow, Maximilian Kleinert, Christian Pehmøller, Clara Prats, Tim T. Chiu, Amira Klip, Erik A. Richter & Thomas E. Jensen. (2014) Akt and Rac1 signaling are jointly required for insulin-stimulated glucose uptake in skeletal muscle and downregulated in insulin resistance. Cellular Signalling 26:2, pages 323-331.
Crossref
A Tsuchiya, T Kanno & T Nishizaki. (2014) PI3 kinase directly phosphorylates Akt1/2 at Ser473/474 in the insulin signal transduction pathway. Journal of Endocrinology 220:1, pages 49-59.
Crossref
Ariel Contreras-Ferrat, Paola Llanos, César Vásquez, Alejandra Espinosa, César Osorio-Fuentealba, Manuel Arias-Calderon, Sergio Lavandero, Amira Klip, Cecilia Hidalgo & Enrique Jaimovich. (2014) Insulin elicits a ROS-activated and an IP3-dependent Ca2+ release; both impinge on GLUT4 translocation. Journal of Cell Science.
Crossref
Bao-Hong Lee, Chia-Chen Lee, Yu-Hsiang Cheng, Wen-Chang Chang, Wei-Hsuan Hsu & She-Ching Wu. (2013) Graptopetalum paraguayense and resveratrol ameliorates carboxymethyllysine (CML)-induced pancreas dysfunction and hyperglycemia. Food and Chemical Toxicology 62, pages 492-498.
Crossref
Greg C. Smith, Wee-Kiat Ong, Jessica L. Costa, Maureen Watson, Jillian Cornish, Andrew Grey, Greg D. Gamble, Michelle Dickinson, Sophie Leung, Gordon W. Rewcastle, Weiping Han & Peter R. Shepherd. (2013) Extended treatment with selective phosphatidylinositol 3-kinase and mTOR inhibitors has effects on metabolism, growth, behaviour and bone strength. FEBS Journal 280:21, pages 5337-5349.
Crossref
Shao-Wen Weng, Hsiao-Mei Kuo, Jiin-Haur Chuang, Tsu-Kung Lin, Hui-Lin Huang, Hung-Yu Lin, Chia-Wei Liou & Pei-Wen Wang. (2013) Study of insulin resistance in cybrid cells harboring diabetes-susceptible and diabetes-protective mitochondrial haplogroups. Mitochondrion 13:6, pages 888-897.
Crossref
Hajin Nam, In Koo Hwang, Harry Jung, Seung-Hae Kwon, Ok Kyu Park & Jun Gyo Suh. (2013) Fagopyritol, a Derivative of D-chiro-inositol, Induces GLUT4 Translocation via Actin Filament Remodeling in L6-GLUT4myc Skeletal Muscle Cells. Journal of Life Science 23:9, pages 1163-1169.
Crossref
P.N. Morato, P.C.B. Lollo, C.S. Moura, T.M. Batista, E.M. Carneiro & J. Amaya-Farfan. (2013) A dipeptide and an amino acid present in whey protein hydrolysate increase translocation of GLUT-4 to the plasma membrane in Wistar rats. Food Chemistry 139:1-4, pages 853-859.
Crossref
Harsh Sancheti, Garnik Akopian, Fei Yin, Roberta D. Brinton, John P. Walsh & Enrique Cadenas. (2013) Age-Dependent Modulation of Synaptic Plasticity and Insulin Mimetic Effect of Lipoic Acid on a Mouse Model of Alzheimer’s Disease. PLoS ONE 8:7, pages e69830.
Crossref
Yong-Tae Jeong, Yong Deuk Kim, Young-Mi Jung, Dong-Chan Park, Dong-Sub Lee, Sae-Kwang Ku, Xian Li, Yue Lu, Guang Hsuan Chao, Keuk-Jun Kim, Jai-Youl Lee, Moon-Chang Baek, Wonku Kang, Seung-Lark Hwang & Hyeun Wook Chang. (2013) Low Molecular Weight Fucoidan Improves Endoplasmic Reticulum Stress-Reduced Insulin Sensitivity through AMP-Activated Protein Kinase Activation in L6 Myotubes and Restores Lipid Homeostasis in a Mouse Model of Type 2 Diabetes. Molecular Pharmacology 84:1, pages 147-157.
Crossref
Seung-Keun Hong, Joseph H. Jeong, Andrew M. Chan & Jong-In Park. (2013) AKT upregulates B-Raf Ser445 phosphorylation and ERK1/2 activation in prostate cancer cells in response to androgen depletion. Experimental Cell Research 319:12, pages 1732-1743.
Crossref
Assaf Rudich & Amira Klip. (2013) Putting Rac1 on the Path to Glucose Uptake. Diabetes 62:6, pages 1831-1832.
Crossref
Tim Ting Chiu, Yi Sun, Alexandra Koshkina & Amira Klip. (2013) Rac-1 Superactivation Triggers Insulin-independent Glucose Transporter 4 (GLUT4) Translocation That Bypasses Signaling Defects Exerted by c-Jun N-terminal kinase (JNK)- and Ceramide-induced Insulin Resistance. Journal of Biological Chemistry 288:24, pages 17520-17531.
Crossref
Eun-Kyung Yoon, Yong-Tae Jeong, Xian Li, Song-Cui, Dong-Chan Park, Yong-Hoon Kim, Yong Deuk Kim, Hyeun Wook Chang, Sang-Han Lee & Seung-Lark Hwang. (2013) Glyceollin improves endoplasmic reticulum stress-induced insulin resistance through CaMKK-AMPK pathway in L6 myotubes. The Journal of Nutritional Biochemistry 24:6, pages 1053-1061.
Crossref
Anton Scott Goustin, Nada Derar & Abdul B. Abou-Samra. (2013) Ahsg-fetuin blocks the metabolic arm of insulin action through its interaction with the 95-kD β-subunit of the insulin receptor. Cellular Signalling 25:4, pages 981-988.
Crossref
Lorna J. HaleRichard J. M. Coward. (2012) Insulin signalling to the kidney in health and disease. Clinical Science 124:6, pages 351-370.
Crossref
Hayley M. O'Neill. (2013) AMPK and Exercise: Glucose Uptake and Insulin Sensitivity. Diabetes & Metabolism Journal 37:1, pages 1.
Crossref
C-W. Wu, K.K. Biggar & K.B. Storey. (2013) Biochemical adaptations of mammalian hibernation: exploring squirrels as a perspective model for naturally induced reversible insulin resistance. Brazilian Journal of Medical and Biological Research 46:1, pages 1-13.
Crossref
Li-Zhong Liu, Stanley C.K. Cheung, Lin-Lin Lan, Stanley K.S. Ho, Juliana C.N. Chan & Peter C.Y. Tong. (2013) Microtubule network is required for insulin-induced signal transduction and actin remodeling. Molecular and Cellular Endocrinology 365:1, pages 64-74.
Crossref
J. P. Zhao, J. Bao, X. J. Wang, H. C. Jiao, Z. G. Song & H. Lin. (2012) Altered gene and protein expression of glucose transporter1 underlies dexamethasone inhibition of insulin-stimulated glucose uptake in chicken muscles1. Journal of Animal Science 90:12, pages 4337-4345.
Crossref
Parama Dey, Satyanarayana Rachagani, Subhankar Chakraborty, Pankaj K. Singh, Xiangshan Zhao, Channabasavaiah Basavaraju Gurumurthy, Judy M. Anderson, Subodh Lele, Michael A. Hollingsworth, Vimla Band & Surinder K. Batra. (2012) Overexpression of Ecdysoneless in Pancreatic Cancer and Its Role in Oncogenesis by Regulating Glycolysis. Clinical Cancer Research 18:22, pages 6188-6198.
Crossref
Dhara N. AminNatalia SerginaLionel LimAndrei GogaMark M. Moasser. (2012) HER3 signalling is regulated through a multitude of redundant mechanisms in HER2-driven tumour cells. Biochemical Journal 447:3, pages 417-425.
Crossref
Jiarong LiuWei ZhangGin C. ChuangHelliner S. Hill, Ling TianYuchang Fu, Douglas R. MoelleringW. Timothy Garvey. (2012) Role of TRIB3 in regulation of insulin sensitivity and nutrient metabolism during short-term fasting and nutrient excess. American Journal of Physiology-Endocrinology and Metabolism 303:7, pages E908-E916.
Crossref
Liping Huang, Catherine P. Kirschke, Yu-An E. Lay, Lauren B. Levy, Danielle E. Lamirande & Patrick H. Zhang. (2012) Znt7-null Mice Are More Susceptible to Diet-induced Glucose Intolerance and Insulin Resistance. Journal of Biological Chemistry 287:40, pages 33883-33896.
Crossref
G. Naresh, N. Jaiswal, P. Sukanya, A.K. Srivastava, A.K. Tamrakar & T. Narender. (2012) Glucose uptake stimulatory effect of 4-hydroxypipecolic acid by increased GLUT 4 translocation in skeletal muscle cells. Bioorganic & Medicinal Chemistry Letters 22:17, pages 5648-5651.
Crossref
Young-Sil Lee, Byung-Yoon Cha, Sun-Sil Choi, Yumiko Harada, Bong-Keun Choi, Takayuki Yonezawa, Toshiaki Teruya, Kazuo Nagai & Je-Tae Woo. (2012) Fargesin improves lipid and glucose metabolism in 3T3-L1 adipocytes and high-fat diet-induced obese mice. BioFactors 38:4, pages 300-308.
Crossref
Mandy Sawitzky, Anja Zeissler, Martina Langhammer, Maximilian Bielohuby, Peggy Stock, Harald M. Hammon, Solvig Görs, Cornelia C. Metges, Barbara J. M. Stoehr, Martin Bidlingmaier, Carolin Fromm-Dornieden, Bernhard G. Baumgartner, Bruno Christ, Bertram Brenig, Gerhard Binder, Friedrich Metzger, Ulla Renne & Andreas Hoeflich. (2012) Phenotype Selection Reveals Coevolution of Muscle Glycogen and Protein and PTEN as a Gate Keeper for the Accretion of Muscle Mass in Adult Female Mice. PLoS ONE 7:6, pages e39711.
Crossref
Adithya Raghavan, Tatiana Sheiko, Brett H. Graham & William J. Craigen. (2012) Voltage-dependant anion channels: Novel insights into isoform function through genetic models. Biochimica et Biophysica Acta (BBA) - Biomembranes 1818:6, pages 1477-1485.
Crossref
Tamar Brutman-Barazani, Miriam Horovitz-Fried, Shlomit Aga-Mizrachi, Chagit Brand, Chaya Brodie, Jagoda Rosa & Sanford R. Sampson. (2012) Protein kinase Cδ but not PKCα is involved in insulin-induced glucose metabolism in hepatocytes. Journal of Cellular Biochemistry 113:6, pages 2064-2076.
Crossref
A. Maharaj, L. Zhu, F. Huang, H. Qiu, H. Li, C. Y. Zhang, T. Jin & Q. Wang. (2012) Ectopic expression of glucagon receptor in skeletal muscles improves glucose homeostasis in a mouse model of diabetes. Diabetologia 55:5, pages 1458-1468.
Crossref
N Deblon, L Bourgoin, C Veyrat-Durebex, M Peyrou, M Vinciguerra, A Caillon, C Maeder, M Fournier, X Montet, F Rohner-Jeanrenaud & M Foti. (2012) Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats. British Journal of Pharmacology 165:7, pages 2325-2340.
Crossref
Seung-Hong Lee, Sung-Myung Kang, Seok-Chun Ko, Dae-Ho Lee & You-Jin Jeon. (2012) Octaphlorethol A, a novel phenolic compound isolated from a brown alga, Ishige foliacea, increases glucose transporter 4-mediated glucose uptake in skeletal muscle cells. Biochemical and Biophysical Research Communications 420:3, pages 576-581.
Crossref
Nodi Dehvari, Dana S Hutchinson, Julia Nevzorova, Olof S Dallner, Masaaki Sato, Martina Kocan, Jon Merlin, Bronwyn A Evans, Roger J Summers & Tore Bengtsson. (2012) β2-Adrenoceptors increase translocation of GLUT4 via GPCR kinase sites in the receptor C-terminal tail. British Journal of Pharmacology 165:5, pages 1442-1456.
Crossref
W. AOI, Y. NAITO, H. TOKUDA, Y. TANIMURA, T. OYA-ITO & T. YOSHIKAWA. (2012) Exercise-Induced Muscle Damage Impairs Insulin Signaling Pathway Associated With IRS-1 Oxidative Modification. Physiological Research, pages 81-88.
Crossref
Seung-Lark Hwang, Xian Li, Jai-Youl Lee & Hyeun Wook Chang. (2012) Improved insulin sensitivity by rapamycin is associated with reduction of mTOR and S6K1 activities in L6 myotubes. Biochemical and Biophysical Research Communications 418:2, pages 402-407.
Crossref
Hyun-Jung Koo, Ying Piao & Youngmi Kim Pak. (2012) Endoplasmic Reticulum Stress Impairs Insulin Signaling through Mitochondrial Damage in SH-SY5Y Cells. Neurosignals 20:4, pages 265-280.
Crossref
Humberto Nicastro, Claudia Ribeiro da Luz, Daniela Fojo Seixas Chaves, Luiz Roberto Grassmann Bechara, Vanessa Azevedo Voltarelli, Marcelo Macedo Rogero & Antonio Herbert Lancha. (2012) Does Branched-Chain Amino Acids Supplementation Modulate Skeletal Muscle Remodeling through Inflammation Modulation? Possible Mechanisms of Action. Journal of Nutrition and Metabolism 2012, pages 1-10.
Crossref
Jiyun Ahn, Hyunjung Lee, Chang Hwa Chung & Taeyoul Ha. (2011) High fat diet induced downregulation of microRNA-467b increased lipoprotein lipase in hepatic steatosis. Biochemical and Biophysical Research Communications 414:4, pages 664-669.
Crossref
Girish Kewalramani, Lisbeth Nielsen Fink, Farzad Asadi & Amira Klip. (2011) Palmitate-Activated Macrophages Confer Insulin Resistance to Muscle Cells by a Mechanism Involving Protein Kinase C θ and ε. PLoS ONE 6:10, pages e26947.
Crossref
Tim T. Chiu, Thomas E. Jensen, Lykke Sylow, Erik A. Richter & Amira Klip. (2011) Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle. Cellular Signalling 23:10, pages 1546-1554.
Crossref
Cui Hao, Jiejie Hao, Wei Wang, Zhangrun Han, Guangsheng Li, Lijuan Zhang, Xia Zhao & Guangli Yu. (2011) Insulin Sensitizing Effects of Oligomannuronate-Chromium (III) Complexes in C2C12 Skeletal Muscle Cells. PLoS ONE 6:9, pages e24598.
Crossref
Chun Fa Huang, Ya Wen Chen, Ching Yao Yang, Keh Sung Tsai, Rong Sen Yang & Shing Hwa Liu. (2011) Arsenic and diabetes: Current perspectives. The Kaohsiung Journal of Medical Sciences 27:9, pages 402-410.
Crossref
Xiangyang Xie, Zhenwei Gong, Virginie Mansuy-Aubert, Qiong L. Zhou, Suren A. Tatulian, Daniel Sehrt, Florian Gnad, Laurence M. Brill, Khatereh Motamedchaboki, Yu Chen, Michael P. Czech, Matthias Mann, Marcus Krüger & Zhen Y. Jiang. (2011) C2 Domain-Containing Phosphoprotein CDP138 Regulates GLUT4 Insertion into the Plasma Membrane. Cell Metabolism 14:3, pages 378-389.
Crossref
Evert M. van Schothorst, Annelies Bunschoten, Eline Verlinde, Patrick Schrauwen & Jaap Keijer. (2011) Glycemic index differences of high-fat diets modulate primarily lipid metabolism in murine adipose tissue. Physiological Genomics 43:15, pages 942-949.
Crossref
Eun Mi Choi. (2011) Kaempferol protects MC3T3-E1 cells through antioxidant effect and regulation of mitochondrial function. Food and Chemical Toxicology 49:8, pages 1800-1805.
Crossref
Xiu-Qing Yao, Xiao-Xue Zhang, Yang-Yang Yin, Bin Liu, Dan-Ju Luo, Dan Liu, Ning-Ning Chen, Zhong-Fei Ni, Xiong Wang, Qun Wang, Jian-Zhi Wang & Gong-Ping Liu. (2011) Glycogen synthase kinase-3β regulates Tyr307 phosphorylation of protein phosphatase-2A via protein tyrosine phosphatase 1B but not Src. Biochemical Journal 437:2, pages 335-344.
Crossref
Masayuki Hirata, Mutsumi Suzuki, Rika Ishii, Reiko Satow, Takafumi Uchida, Tomoya Kitazumi, Tsutomu Sasaki, Tadahiro Kitamura, Hideki Yamaguchi, Yoshikazu Nakamura & Kiyoko Fukami. (2011) Genetic Defect in Phospholipase Cδ1 Protects Mice From Obesity by Regulating Thermogenesis and Adipogenesis. Diabetes 60:7, pages 1926-1937.
Crossref
Andrew J. Smith, Jürgen Daut & Blanche Schwappach. (2011) Membrane Proteins as 14-3-3 Clients in Functional Regulation and Intracellular Transport. Physiology 26:3, pages 181-191.
Crossref
Da-Qing Yang, Marie-Jo Halaby, Yan Li, Jody C. Hibma & Paul Burn. (2011) Cytoplasmic ATM protein kinase: an emerging therapeutic target for diabetes, cancer and neuronal degeneration. Drug Discovery Today 16:7-8, pages 332-338.
Crossref
M Colombi, K D Molle, D Benjamin, K Rattenbacher-Kiser, C Schaefer, C Betz, A Thiemeyer, U Regenass, M N Hall & C Moroni. (2010) Genome-wide shRNA screen reveals increased mitochondrial dependence upon mTORC2 addiction. Oncogene 30:13, pages 1551-1565.
Crossref
Heidi K. OrtmeyerMini P. SajanAtsushi MiuraYoshinore KanohJose RivasYongxiang LiMary L. StandaertAlice S. RyanNoni L. BodkinRobert V. FareseBarbara C. Hansen. (2011) Insulin Signaling and Insulin Sensitizing in Muscle and Liver of Obese Monkeys: Peroxisome Proliferator-Activated Receptor Gamma Agonist Improves Defective Activation of Atypical Protein Kinase C. Antioxidants & Redox Signaling 14:2, pages 207-219.
Crossref
Bo ZhaoJessica C. Mar, Seiji Maruo, Sungwook LeeBenjamin E. GewurzEric JohannsenKristina Holton, Renee Rubio, Kenzo Takada, John Quackenbush & Elliott Kieff. (2010) Epstein–Barr virus nuclear antigen 3C regulated genes in lymphoblastoid cell lines. Proceedings of the National Academy of Sciences 108:1, pages 337-342.
Crossref
Wataru Aoi, Yuji Naito & Toshikazu Yoshikawa. (2011) Dietary Exercise as a Novel Strategy for the Prevention and Treatment of Metabolic Syndrome: Effects on Skeletal Muscle Function. Journal of Nutrition and Metabolism 2011, pages 1-11.
Crossref
Sandra Pereira & Adria Giacca. 2011. Insulin Resistance and Cancer. Insulin Resistance and Cancer 1 52 .
Yi Sun, Philip J. Bilan, Zhi Liu & Amira Klip. (2010) Rab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cells. Proceedings of the National Academy of Sciences 107:46, pages 19909-19914.
Crossref
Aimee J. Marko, Rebecca A. Miller, Alina Kelman & Kenneth A. Frauwirth. (2010) Induction of Glucose Metabolism in Stimulated T Lymphocytes Is Regulated by Mitogen-Activated Protein Kinase Signaling. PLoS ONE 5:11, pages e15425.
Crossref
Paulo A. Amorim, T. Dung Nguyen, Yasushige Shingu, Michael Schwarzer, Friedrich W. Mohr, Andrea Schrepper & Torsten Doenst. (2010) Myocardial infarction in rats causes partial impairment in insulin response associated with reduced fatty acid oxidation and mitochondrial gene expression. The Journal of Thoracic and Cardiovascular Surgery 140:5, pages 1160-1167.
Crossref
Tim Ting Chiu, Nish PatelAlisa E. Shaw, James R. Bamburg & Amira Klip. (2010) Arp2/3- and Cofilin-coordinated Actin Dynamics Is Required for Insulin-mediated GLUT4 Translocation to the Surface of Muscle Cells. Molecular Biology of the Cell 21:20, pages 3529-3539.
Crossref
Nadeeja Wijesekara, Mansa Krishnamurthy, Alpana Bhattacharjee, Aamir Suhail, Gary Sweeney & Michael B. Wheeler. (2010) Adiponectin-induced ERK and Akt Phosphorylation Protects against Pancreatic Beta Cell Apoptosis and Increases Insulin Gene Expression and Secretion*. Journal of Biological Chemistry 285:44, pages 33623-33631.
Crossref
Li-Zhong Liu, Stanley C.K. Cheung, Lin-Lin Lan, Stanley K.S. Ho, Juliana C.N. Chan & Peter C.Y. Tong. (2010) The pivotal role of protein kinase C zeta (PKCzeta) in insulin- and AMP-activated protein kinase (AMPK)-mediated glucose uptake in muscle cells. Cellular Signalling 22:10, pages 1513-1522.
Crossref
Do Yeon Kim, Hai-Dan Yuan, Bo Huang, Hai-Yan Quan & Sung Hyun Chung. (2010) Ginsenoside 20(R)-Rg3 stimulates glucose uptake in C2C12 myotubes via CaMKK-AMPK pathways. Food Science and Biotechnology 19:5, pages 1277-1282.
Crossref
Changkeun Kang & Euikyung Kim. (2010) Synergistic effect of curcumin and insulin on muscle cell glucose metabolism. Food and Chemical Toxicology 48:8-9, pages 2366-2373.
Crossref
Terry J. Smith. (2010) Insulin-Like Growth Factor-I Regulation of Immune Function: A Potential Therapeutic Target in Autoimmune Diseases?. Pharmacological Reviews 62:2, pages 199-236.
Crossref
Masashi Morifuji, Atsushi Kanda, Jinichiro Koga, Kentaro Kawanaka & Mitsuru Higuchi. (2009) Post-exercise carbohydrate plus whey protein hydrolysates supplementation increases skeletal muscle glycogen level in rats. Amino Acids 38:4, pages 1109-1115.
Crossref
Jiarong Liu, Xuxia WuJohn L. Franklin, Joseph L. Messina, Helliner S. HillDouglas R. MoelleringR. Grace WaltonMitchell Martin & W. Timothy Garvey. (2010) Mammalian Tribbles homolog 3 impairs insulin action in skeletal muscle: role in glucose-induced insulin resistance . American Journal of Physiology-Endocrinology and Metabolism 298:3, pages E565-E576.
Crossref
Anindita Biswas, Sushmita Bhattacharya, Suman Dasgupta, Rakesh Kundu, Sib Sankar Roy, Bikas C. Pal & Samir Bhattacharya. (2009) Insulin resistance due to lipid-induced signaling defects could be prevented by mahanine. Molecular and Cellular Biochemistry 336:1-2, pages 97-107.
Crossref
Makoto Fujii, Takashi Kanematsu, Hitoshi Ishibashi, Kiyoko Fukami, Tadaomi Takenawa, Keiichi I. Nakayama, Stephen J. Moss, Junichi Nabekura & Masato Hirata. (2010) Phospholipase C-related but Catalytically Inactive Protein Is Required for Insulin-induced Cell Surface Expression of γ-Aminobutyric Acid Type A Receptors. Journal of Biological Chemistry 285:7, pages 4837-4846.
Crossref
Wei Yun Zhang, Jung-Jin Lee, In-Su Kim, Yohan Kim, Jeong-Sook Park & Chang-Seon Myung. (2010) 7-O-Methylaromadendrin Stimulates Glucose Uptake and Improves Insulin Resistance in Vitro. Biological and Pharmaceutical Bulletin 33:9, pages 1494-1499.
Crossref
Min Liu, Ke Wu, Xianqing Mao, Yong Wu & Jingping Ouyang. (2010) Astragalus polysaccharide improves insulin sensitivity in KKAy mice: Regulation of PKB/GLUT4 signaling in skeletal muscle. Journal of Ethnopharmacology 127:1, pages 32-37.
Crossref
Nhung Thuy Dang, Masanori Yamaguchi, Tadashi Yoshida, Ken-ichi Yoshida & Hitoshi Ashida. 2010. Basic and Applied Aspects. Basic and Applied Aspects 327 331 .
Jing-fang Zhang, Jing-ping Ou Yang, Guang-hao Wang, Zhengyuan Xia, Sheng Zhong Duan & Yong Wu. (2010) Role of PKCζ translocation in the development of type 2 diabetes in rats following continuous glucose infusion. Diabetes/Metabolism Research and Reviews 26:1, pages 59-70.
Crossref
Min Kim, Byung Yong Ahn, Ji Seon Lee, Sung Soo Chung, Soo Lim, Sang Gyu Park, Hye Seung Jung, Hong Kyu Lee & Kyong Soo Park. (2009) The ginsenoside Rg3 has a stimulatory effect on insulin signaling in L6 myotubes. Biochemical and Biophysical Research Communications 389:1, pages 70-73.
Crossref
Hee Yun, Jong Hwa Lee, Chang Eun Park, Min-Jung Kim, Byung-Il Min, Hyunsu Bae, Wonchae Choe, Insug Kang, Sung-Soo Kim & Joohun Ha. (2009) Inulin Increases Glucose Transport in C2C12 Myotubes and HepG2 Cells via Activation of AMP-Activated Protein Kinase and Phosphatidylinositol 3-Kinase Pathways. Journal of Medicinal Food 12:5, pages 1023-1028.
Crossref
A. Krook & J. R. Zierath. (2009) Specificity of insulin signalling in human skeletal muscle as revealed by small interfering RNA. Diabetologia 52:7, pages 1231-1239.
Crossref
Ilana Kachko, Adva Maissel, Livnat Mazor, Ronit Ben-Romano, Robert T. Watson, June C. Hou, Jeffrey E. Pessin, Nava Bashan & Assaf Rudich. (2009) Postreceptoral Adipocyte Insulin Resistance Induced by Nelfinavir Is Caused by Insensitivity of PKB/Akt to Phosphatidylinositol-3,4,5-Trisphosphate. Endocrinology 150:6, pages 2618-2626.
Crossref
Amira Klip. (2009) The many ways to regulate glucose transporter 4This paper is one of a selection of papers published in this Special Issue, entitled 14th International Biochemistry of Exercise Conference – Muscles as Molecular and Metabolic Machines, and has undergone the Journal’s usual peer review process.. Applied Physiology, Nutrition, and Metabolism 34:3, pages 481-487.
Crossref
Sigalit Boura-Halfon & Yehiel Zick. (2009) Phosphorylation of IRS proteins, insulin action, and insulin resistance. American Journal of Physiology-Endocrinology and Metabolism 296:4, pages E581-E591.
Crossref
Seung Hee Jung, Hee Jung Seol, Su Jin Jeon, Kun Ho Son & Jong Ran Lee. (2009) Insulin-sensitizing activities of tanshinones, diterpene compounds of the root of Salvia miltiorrhiza Bunge. Phytomedicine 16:4, pages 327-335.
Crossref
J.P. Zhao, H. Lin, H.C. Jiao & Z.G. Song. (2009) Corticosterone suppresses insulin- and NO-stimulated muscle glucose uptake in broiler chickens (Gallus gallus domesticus). Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 149:3, pages 448-454.
Crossref
Daniel J. Fazakerley, Scott P. Lawrence, Vladimir A. Lizunov, Samuel W. Cushman & Geoffrey D. Holman. (2009) A common trafficking route for GLUT4 in cardiomyocytes in response to insulin, contraction and energy-status signalling. Journal of Cell Science 122:5, pages 727-734.
Crossref
C.N. Vishnu Prasad, S. Suma Mohan, Asoke Banerji & Anilkumar Gopalakrishnapillai. (2009) Kaempferitrin inhibits GLUT4 translocation and glucose uptake in 3T3-L1 adipocytes. Biochemical and Biophysical Research Communications 380:1, pages 39-43.
Crossref
Masashi MORIFUJI, Jinichiro KOGA, Kentaro KAWANAKA & Mitsuru HIGUCHI. (2009) Branched-Chain Amino Acid-Containing Dipeptides, Identified from Whey Protein Hydrolysates, Stimulate Glucose Uptake Rate in L6 Myotubes and Isolated Skeletal Muscles. Journal of Nutritional Science and Vitaminology 55:1, pages 81-86.
Crossref
Jeong‐Ho Kim, Rebecca A. Bachmann & Jie Chen. 2009. Insulin and IGFs. Insulin and IGFs 613 633 .
Sigalit Boura‐Halfon & Yehiel Zick. 2009. Insulin and IGFs. Insulin and IGFs 313 349 .
Shuji Ueda, Tohru Kataoka & Takaya Satoh. (2008) Activation of the small GTPase Rac1 by a specific guanine-nucleotide-exchange factor suffices to induce glucose uptake into skeletal-muscle cells. Biology of the Cell 100:11, pages 645-661.
Crossref
Maiko Higuchi, Keisuke Onishi, Chikako Kikuchi & Yukiko Gotoh. (2008) Scaffolding function of PAK in the PDK1–Akt pathway. Nature Cell Biology 10:11, pages 1356-1364.
Crossref
J.K. Morris, H. Zhang, A.A. Gupte, G.L. Bomhoff, J.A. Stanford & P.C. Geiger. (2008) Measures of striatal insulin resistance in a 6-hydroxydopamine model of Parkinson's disease. Brain Research 1240, pages 185-195.
Crossref
Jun-Te Hsu, Wen-Hong Kan, Ya-Ching Hsieh, Mashkoor A. Choudhry, Martin G. Schwacha, Kirby I. Bland & Irshad H. Chaudry. (2008) MECHANISM OF ESTROGEN-MEDIATED IMPROVEMENT IN CARDIAC FUNCTION AFTER TRAUMA-HEMORRHAGE. Shock 30:4, pages 372-378.
Crossref

Displaying 200 of 437 citing articles. Use the download link below to view the full list of citing articles.

Download full citations list

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.