22
Views
79
CrossRef citations to date
0
Altmetric
Transcriptional Regulation

On the Mechanism by which Alkaline pH Prevents Expression of an Acid-Expressed Gene

&
Pages 3355-3363 | Received 30 Aug 1999, Accepted 17 Feb 2000, Published online: 27 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Dov Prusky, Shiri Barad, Dana Ment & Fangcheng Bi. (2016) The pH modulation by fungal secreted molecules: a mechanism affecting pathogenicity by postharvest pathogens. Israel Journal of Plant Sciences 63:1, pages 22-30.
Read now
Teresa R. O'Meara, Wenjie Xu, Kyla M. Selvig, Matthew J. O'Meara, Aaron P. Mitchell & J. Andrew Alspaugh. (2014) The Rim101 Transcription Factor Directly Regulates Genes Required for Adaptation to the Host. Molecular and Cellular Biology 34:4, pages 673-684.
Read now
Kazuki NAGAMINE, Kenji MURASHIMA, Taku KATO, Hitoshi SHIMOI & Kiyoshi ITO. (2003) Mode of α-Amylase Production by the Shochu Koji Mold Aspergillus kawachii . Bioscience, Biotechnology, and Biochemistry 67:10, pages 2194-2202.
Read now
José M. Mingot, Eduardo A. Espeso, Eliecer Dı́ez & MiguelÁ. Peñalva. (2001) Ambient pH Signaling Regulates Nuclear Localization of the Aspergillus nidulans PacC Transcription Factor. Molecular and Cellular Biology 21:5, pages 1688-1699.
Read now

Articles from other publishers (74)

Héctor Toledo, Clara Inés Sánchez, Laura Marín, Jorge Amich & José Antonio Calera. (2021) Regulation of zinc homeostatic genes by environmental pH in the filamentous fungus Aspergillus fumigatus . Environmental Microbiology 24:2, pages 643-666.
Crossref
Xiaoxuan Su, Xiaoru Yang, Hu Li, Hongtao Wang, Yingmu Wang, Jianxin Xu, Kai Ding & Yong-guan Zhu. (2021) Bacterial communities are more sensitive to ocean acidification than fungal communities in estuarine sediments. FEMS Microbiology Ecology 97:5.
Crossref
Irene Picazo, Oier Etxebeste, Elena Requena, Aitor Garzia & Eduardo Antonio Espeso. (2020) Defining the transcriptional responses of Aspergillus nidulans to cation/alkaline pH stress and the role of the transcription factor SltA. Microbial Genomics 6:8.
Crossref
Carmit Ziv, Dilip Kumar, Noa Sela, Maxim Itkin, Sergey Malitsky, Arthur A. Schaffer & Dov B. Prusky. (2020) Sugar‐regulated susceptibility of tomato fruit to Colletotrichum and Penicillium requires differential mechanisms of pathogenicity and fruit responses . Environmental Microbiology 22:7, pages 2870-2891.
Crossref
Mohamed Amine Gacem, Aminata Ould El Hadj-Khelil, Badreddine Boudjemaa & Hiba Gacem. 2020. Sustainable Agriculture Reviews 40. Sustainable Agriculture Reviews 40 1 42 .
Elise Reus, Mikkel Rank Nielsen & Rasmus John Normand Frandsen. (2019) Metabolic and regulatory insights from the experimental horizontal gene transfer of the aurofusarin and bikaverin gene clusters to Aspergillus nidulans . Molecular Microbiology 112:6, pages 1684-1700.
Crossref
C Snyman, LW Theron & B Divol. (2019) Understanding the regulation of extracellular protease gene expression in fungi: a key step towards their biotechnological applications. Applied Microbiology and Biotechnology 103:14, pages 5517-5532.
Crossref
Kalyani Prasad, Kiran Kumar Sharma & Pooja Bhatnagar-Mathur. 2019. Nutritional Quality Improvement in Plants. Nutritional Quality Improvement in Plants 289 376 .
Yong Chen, Boqiang Li, Xiaodi Xu, Zhanquan Zhang & Shiping Tian. (2018) The pH-responsive PacC transcription factor plays pivotal roles in virulence and patulin biosynthesis in Penicillium expansum . Environmental Microbiology 20:11, pages 4063-4078.
Crossref
Sofiya A. Bondarenko, Elena A. Ianutsevich, Olga A. Danilova, Alexey A. Grum-Grzhimaylo, Ekaterina R. Kotlova, Olga V. Kamzolkina, Elena N. Bilanenko & Vera M. Tereshina. (2017) Membrane lipids and soluble sugars dynamics of the alkaliphilic fungus Sodiomyces tronii in response to ambient pH. Extremophiles 21:4, pages 743-754.
Crossref
Fangcheng Bi, Shiri Barad, Dana Ment, Neta Luria, Amit Dubey, Virginia Casado, Nofar Glam, Jose Diaz Mínguez, Eduardo A. Espeso, Robert Fluhr & Dov Prusky. (2016) Carbon regulation of environmental pH by secreted small molecules that modulate pathogenicity in phytopathogenic fungi. Molecular Plant Pathology 17:8, pages 1178-1195.
Crossref
Daniel Lucena-Agell, América Hervás-Aguilar, Tatiana Múnera-Huertas, Olga Pougovkina, Joanna Rudnicka, Antonio Galindo, Joan Tilburn, Herbert N. ArstJrJr & Miguel A. Peñalva. (2016) Mutational analysis of the Aspergillus ambient pH receptor PalH underscores its potential as a target for antifungal compounds . Molecular Microbiology 101:6, pages 982-1002.
Crossref
Laura Mellado, Herbert N. ArstJr.Jr. & Eduardo A. Espeso. (2016) Proteolytic activation of both components of the cation stress–responsive Slt pathway in Aspergillus nidulans . Molecular Biology of the Cell 27:16, pages 2598-2612.
Crossref
Emi Kunitake, Daisuke Hagiwara, Kentaro Miyamoto, Kyoko Kanamaru, Makoto Kimura & Tetsuo Kobayashi. (2016) Regulation of genes encoding cellulolytic enzymes by Pal-PacC signaling in Aspergillus nidulans. Applied Microbiology and Biotechnology 100:8, pages 3621-3635.
Crossref
Henk‐Jan Bussink, Elaine M. Bignell, Tatiana Múnera‐Huertas, Daniel Lucena‐Agell, Claudio Scazzocchio, Eduardo A. Espeso, Margherita Bertuzzi, Joanna Rudnicka, Susana Negrete‐Urtasun, Maria M. Peñas‐Parilla, Lynne Rainbow, Miguel Á. Peñalva, Herbert N. ArstJr.Jr. & Joan Tilburn. (2015) Refining the pH response in A spergillus nidulans : a modulatory triad involving PacX , a novel zinc binuclear cluster protein . Molecular Microbiology 98:6, pages 1051-1072.
Crossref
Yonathan Lukito, Tetsuya Chujo & Barry Scott. (2015) Molecular and cellular analysis of the pH response transcription factor PacC in the fungal symbiont Epichloë festucae. Fungal Genetics and Biology 85, pages 25-37.
Crossref
Laura Mellado, Ana Maria Calcagno-Pizarelli, Robin A. Lockington, Marc S. Cortese, Joan M. Kelly, Herbert N. ArstJr.Jr. & Eduardo A. Espeso. (2015) A second component of the SltA-dependent cation tolerance pathway in Aspergillus nidulans. Fungal Genetics and Biology 82, pages 116-128.
Crossref
Eman Zakaria Gomaa. (2015) Enhancement of γ-Amminobutyric Acid Production by Co-Culturing of Two Lactobacilli Strains. Asian Journal of Biotechnology 7:3, pages 108-118.
Crossref
Dana Ment, Noam Alkan, Neta Luria, Fang-Cheng Bi, Eli Reuveni, Robert Fluhr & Dov Prusky. (2015) A Role of AREB in the Regulation of PACC-Dependent Acid-Expressed-Genes and Pathogenicity of Colletotrichum gloeosporioides . Molecular Plant-Microbe Interactions® 28:2, pages 154-166.
Crossref
Miguel A Peñalva, Daniel Lucena-Agell & Herbert N ArstJr.Jr.. (2014) Liaison alcaline: Pals entice non-endosomal ESCRTs to the plasma membrane for pH signaling. Current Opinion in Microbiology 22, pages 49-59.
Crossref
Yong-Hong Zhou, Lei Hou, Yong-Jun Zhang, Yan-Hua Fan, Zhi-Bing Luo, Dan Jin, Qiao-Sheng Zhou, Yu-Jie Li, You Wang & Yan Pei. (2014) Expression and promoter characterization of BbPacC, a pH response transcription factor gene of the entomopathogenic fungus Beauveria bassiana. Microbiology 160:2, pages 353-361.
Crossref
Shiri Barad, Sigal Brown Horowitz, Ilana Kobiler, Amir Sherman & Dov Prusky. (2014) Accumulation of the Mycotoxin Patulin in the Presence of Gluconic Acid Contributes to Pathogenicity of Penicillium expansum . Molecular Plant-Microbe Interactions® 27:1, pages 66-77.
Crossref
Stéphanie Daval, Lionel Lebreton, Cécile Gracianne, Anne-Yvonne Guillerm-Erckelboudt, Morgane Boutin, Muriel Marchi, Kévin Gazengel & Alain Sarniguet. (2013) Strain-specific variation in a soilborne phytopathogenic fungus for the expression of genes involved in pH signal transduction pathway, pathogenesis and saprophytic survival in response to environmental pH changes. Fungal Genetics and Biology 61, pages 80-89.
Crossref
Noam Alkan, Xiangchun Meng, Gilgi Friedlander, Eli Reuveni, Serenella Sukno, Amir Sherman, Michael Thon, Robert Fluhr & Dov Prusky. (2013) Global Aspects of pacC Regulation of Pathogenicity Genes in Colletotrichum gloeosporioides as Revealed by Transcriptome Analysis . Molecular Plant-Microbe Interactions® 26:11, pages 1345-1358.
Crossref
Tianyuan Zhang, Xuepeng Sun, Qian Xu, Luis González Candelas & Hongye Li. (2013) The pH signaling transcription factor PacC is required for full virulence in Penicillium digitatum. Applied Microbiology and Biotechnology 97:20, pages 9087-9098.
Crossref
Noam AlkanEduardo A. EspesoDov Prusky. (2013) Virulence Regulation of Phytopathogenic Fungi by pH. Antioxidants & Redox Signaling 19:9, pages 1012-1025.
Crossref
Dov PruskyNoam Alkan, Tesfaye Mengiste & Robert Fluhr. (2013) Quiescent and Necrotrophic Lifestyle Choice During Postharvest Disease Development. Annual Review of Phytopathology 51:1, pages 155-176.
Crossref
Ruian Ke, Ken Haynes & Jaroslav Stark. (2013) Modelling the activation of alkaline pH response transcription factor PacC in Aspergillus nidulans: Involvement of a negative feedback loop. Journal of Theoretical Biology 326, pages 11-20.
Crossref
Jiujiang Yu. (2012) Current Understanding on Aflatoxin Biosynthesis and Future Perspective in Reducing Aflatoxin Contamination. Toxins 4:11, pages 1024-1057.
Crossref
Jawad Merhej, Florence Richard-Forget & Christian Barreau. (2011) The pH regulatory factor Pac1 regulates Tri gene expression and trichothecene production in Fusarium graminearum. Fungal Genetics and Biology 48:3, pages 275-284.
Crossref
Cheng-Gang Zou, Hui-Hui Tu, Xian-Yong Liu, Nan Tao & Ke-Qin Zhang. (2010) PacC in the nematophagous fungus Clonostachys rosea controls virulence to nematodes. Environmental Microbiology 12:7, pages 1868-1877.
Crossref
Laurent Nevarez, Valérie Vasseur, Stella Debaets & Georges Barbier. (2010) Use of response surface methodology to optimise environmental stress conditions on Penicillium glabrum, a food spoilage mould. Fungal Biology 114:5-6, pages 490-497.
Crossref
Joan Tilburn, Herbert N. ArstJr.Jr. & Miguel A. Peñalva. 2010. Cellular and Molecular Biology of Filamentous Fungi. Cellular and Molecular Biology of Filamentous Fungi 480 487 .
Michael C. FlickingerJiujiang Yu, Perng‐Kuang Chang, Thomas E. Cleveland & Joan W. Bennett. 2009. Encyclopedia of Industrial Biotechnology. Encyclopedia of Industrial Biotechnology 1 13 .
Donald M. Gardiner, Sheree Osborne, Kemal Kazan & John M. Manners. (2009) Low pH regulates the production of deoxynivalenol by Fusarium graminearum. Microbiology 155:9, pages 3149-3156.
Crossref
Qin Wang & Paul J. Szaniszlo. (2009) Roles of the pH signaling transcription factor PacC in Wangiella (Exophiala) dermatitidis. Fungal Genetics and Biology 46:9, pages 657-666.
Crossref
Stéphane Rolland, Christophe Bruel, Christine Rascle, Vincent Girard, Geneviève Billon-Grand & Nathalie Poussereau. (2009) pH controls both transcription and post-translational processing of the protease BcACP1 in the phytopathogenic fungus Botrytis cinerea. Microbiology 155:6, pages 2097-2105.
Crossref
Philipp Wiemann, Anita Willmann, Marcus Straeten, Karin Kleigrewe, Marita Beyer, Hans-Ulrich Humpf & Bettina Tudzynski. (2009) Biosynthesis of the red pigment bikaverin in Fusarium fujikuroi : genes, their function and regulation . Molecular Microbiology 72:4, pages 931-946.
Crossref
Olga Rodríguez-Galán, Antonio Galindo, América Hervás-Aguilar, Herbert N. ArstJr.Jr. & Miguel A. Peñalva. (2009) Physiological Involvement in pH Signaling of Vps24-mediated Recruitment of Aspergillus PalB Cysteine Protease to ESCRT-III. Journal of Biological Chemistry 284:7, pages 4404-4412.
Crossref
Rebecca A. Hall, Fabien Cottier & Fritz A. Mühlschlegel. 2009. 191 212 .
Emiliana M. SilvaJanaína S. FreitasDiana E. GrasFábio M. SquinaJuliana LealHenrique C.S. SilveiraNilce M. Martinez-RossiAntonio Rossi. (2008) Identification of genes differentially expressed in a strain of the mold Aspergillus nidulans carrying a loss-of-function mutation in the palA gene . Canadian Journal of Microbiology 54:10, pages 803-811.
Crossref
D. Cordoba Cañero & M. I. G. Roncero. (2008) Functional Analyses of Laccase Genes from Fusarium oxysporum . Phytopathology® 98:5, pages 509-518.
Crossref
YOUNG TAE KIM, DOV PRUSKY & JEFFREY A. ROLLINS. (2007) An activating mutation of the Sclerotinia sclerotiorum pac1 gene increases oxalic acid production at low pH but decreases virulence. Molecular Plant Pathology 8:5, pages 611-622.
Crossref
George A. Marzluf. 2007. Methods for General and Molecular Microbiology. Methods for General and Molecular Microbiology 952 964 .
María M. Peñas, América Hervás-Aguilar, Tatiana Múnera-Huertas, Elena Reoyo, Miguel Á. Peñalva, Herbert N. ArstJr.Jr. & Joan Tilburn. (2007) Further Characterization of the Signaling Proteolysis Step in the Aspergillus nidulans pH Signal Transduction Pathway . Eukaryotic Cell 6:6, pages 960-970.
Crossref
Huiqin Chen, Miin-Huey Lee, Margret E. Daub & Kuang-Ren Chung. (2007) Molecular analysis of the cercosporin biosynthetic gene cluster in Cercospora nicotianae. Molecular Microbiology 64:3, pages 755-770.
Crossref
Katherine L. Dekkers, Bang-Jau You, Vivek S. Gowda, Hui-Ling Liao, Miin-Huey Lee, Huey-Jiunn Bau, Peter P. Ueng & Kuang-Ren Chung. (2007) The Cercospora nicotianae gene encoding dual O-methyltransferase and FAD-dependent monooxygenase domains mediates cercosporin toxin biosynthesis. Fungal Genetics and Biology 44:5, pages 444-454.
Crossref
Yong-Un Baek, Samuel J. Martin & Dana A. Davis. (2006) Evidence for Novel pH-Dependent Regulation of Candida albicans Rim101, a Direct Transcriptional Repressor of the Cell Wall β-Glycosidase Phr2 . Eukaryotic Cell 5:9, pages 1550-1559.
Crossref
Mihoko Tominaga, Yun-Hae Lee, Risa Hayashi, Yuji Suzuki, Osamu Yamada, Kazutoshi Sakamoto, Kuniyasu Gotoh & Osamu Akita. (2006) Molecular Analysis of an Inactive Aflatoxin Biosynthesis Gene Cluster in Aspergillus oryzae RIB Strains . Applied and Environmental Microbiology 72:1, pages 484-490.
Crossref
Vera Meyer, Anja Spielvogel, Laura Funk, Joan Tilburn, Herbert N. ArstJr.Jr. & Ulf Stahl. (2005) Alkaline pH-induced up-regulation of the afp gene encoding the antifungal protein (AFP) of Aspergillus giganteus is not mediated by the transcription factor PacC: possible involvement of calcineurin. Molecular Genetics and Genomics 274:3, pages 295-306.
Crossref
Joan Tilburn, Juan C Sánchez-Ferrero, Elena Reoyo, Herbert N ArstJr.Jr. & Miguel A Peñalva. (2005) Mutational Analysis of the pH Signal Transduction Component PalC of Aspergillus nidulans Supports Distant Similarity to BRO1 Domain Family Members . Genetics 171:1, pages 393-401.
Crossref
Rocío Vicentefranqueira, Miguel Ángel Moreno, Fernando Leal & José Antonio Calera. (2005) The zrfA and zrfB Genes of Aspergillus fumigatus Encode the Zinc Transporter Proteins of a Zinc Uptake System Induced in an Acid, Zinc-Depleted Environment . Eukaryotic Cell 4:5, pages 837-848.
Crossref
Miguel A. PeñalvaHerbert N. Arst, Jr.. (2004) Recent Advances in the Characterization of Ambient pH Regulation of Gene Expression in Filamentous Fungi and Yeasts. Annual Review of Microbiology 58:1, pages 425-451.
Crossref
Henrike Lotz, Kai Sohn, Herwig Brunner, Fritz A. Mühlschlegel & Steffen Rupp. (2004) RBR1 , a Novel pH-Regulated Cell Wall Gene of Candida albicans , Is Repressed by RIM101 and Activated by NRG1 . Eukaryotic Cell 3:3, pages 776-784.
Crossref
Martin Eisendle, Harald Oberegger, Rudolf Buttinger, Paul Illmer & Hubertus Haas. (2004) Biosynthesis and Uptake of Siderophores Is Controlled by the PacC-Mediated Ambient-pH Regulatory System in Aspergillus nidulans . Eukaryotic Cell 3:2, pages 561-563.
Crossref
Changbin Chen, Arye Harel, Rena Gorovoits, Oded Yarden & Martin B. Dickman. (2004) MAPK Regulation of Sclerotial Development in Sclerotinia sclerotiorum Is Linked with pH and cAMP Sensing . Molecular Plant-Microbe Interactions® 17:4, pages 404-413.
Crossref
V. Meyer & U. Stahl. 2004. Genetics and Biotechnology. Genetics and Biotechnology 147 163 .
D. A. MacKenzie, D. J. Jeenes & D. B. Archer. 2004. Genetics and Biotechnology. Genetics and Biotechnology 289 315 .
H. N. ArstJr.Jr. & J. Tilburn. 2004. Biochemistry and Molecular Biology. Biochemistry and Molecular Biology 121 128 .
P. Ayoubi, L. Amirneni, L. Hall, S. Krishnan, S. Leite, S. Macwana & R. Prade. 2004. Biochemistry and Molecular Biology. Biochemistry and Molecular Biology 53 60 .
M. J. Hynes & M. A. Davis. 2004. Biochemistry and Molecular Biology. Biochemistry and Molecular Biology 421 435 .
Christoph Stöckmann, Ulrike Maier, Tibor Anderlei, Christof Knocke, Gerd Gellissen & Jochen Büchs. (2003) The oxygen transfer rate as key parameter for the characterization of Hansenula polymorpha screening cultures. Journal of Industrial Microbiology & Biotechnology 30:10, pages 613-622.
Crossref
Joseph E. Flaherty, Anna Maria Pirttilä, Burton H. Bluhm & Charles P. Woloshuk. (2003) PAC1 , a pH-Regulatory Gene from Fusarium verticillioides . Applied and Environmental Microbiology 69:9, pages 5222-5227.
Crossref
Ana M. Ramón & William A. Fonzi. (2003) Diverged Binding Specificity of Rim101p, the Candida albicans Ortholog of PacC . Eukaryotic Cell 2:4, pages 718-728.
Crossref
Zaira Caracuel, M. Isabel G. Roncero, Eduardo A. Espeso, Clara I. González-Verdejo, Fe I. García-Maceira & Antonio Di Pietro. (2003) The pH signalling transcription factor PacC controls virulence in the plant pathogen Fusarium oxysporum. Molecular Microbiology 48:3, pages 765-779.
Crossref
Herbert N ArstJrJr & Miguel A Peñalva. (2003) pH regulation in Aspergillus and parallels with higher eukaryotic regulatory systems. Trends in Genetics 19:4, pages 224-231.
Crossref
D. Bhatnagar, K. C. Ehrlich & T. E. Cleveland. (2003) Molecular genetic analysis and regulation of aflatoxin biosynthesis. Applied Microbiology and Biotechnology 61:2, pages 83-93.
Crossref
Miguel A. Peñalva & Herbert N. ArstJr.Jr.. (2002) Regulation of Gene Expression by Ambient pH in Filamentous Fungi and Yeasts. Microbiology and Molecular Biology Reviews 66:3, pages 426-446.
Crossref
W. A. Fonzi. (2002) Role of pH response in Candida albicans virulence. Mycoses 45:S1, pages 16-21.
Crossref
James A. Fraser, Meryl A. Davis & Michael J. Hynes. (2002) A Gene from Aspergillus nidulans with Similarity to URE2 of Saccharomyces cerevisiae Encodes a Glutathione S -Transferase Which Contributes to Heavy Metal and Xenobiotic Resistance . Applied and Environmental Microbiology 68:6, pages 2802-2808.
Crossref
A.P MacCabe, M Orejas, E.N Tamayo, A Villanueva & D Ramón. (2002) Improving extracellular production of food-use enzymes from Aspergillus nidulans. Journal of Biotechnology 96:1, pages 43-54.
Crossref
Eliecer Díez, Josué Álvaro, Eduardo A. Espeso, Lynne Rainbow, Teresa Suárez, Joan Tilburn, Herbert N. ArstJrJr & Miguel Á. Peñalva. (2002) Activation of the Aspergillus PacC zinc finger transcription factor requires two proteolytic steps . The EMBO Journal 21:6, pages 1350-1359.
Crossref
Claudia I Gonzalez-Lopez, Roman Szabo, Sylvie Blanchin-Roland & Claude Gaillardin. (2002) Genetic Control of Extracellular Protease Synthesis in the Yeast Yarrowia lipolytica . Genetics 160:2, pages 417-427.
Crossref
Stefan Steidl, Michael J Hynes & Axel A Brakhage. (2001) The Aspergillus nidulans multimeric CCAAT binding complex AnCF is negatively autoregulated via its hapB subunit gene. Journal of Molecular Biology 306:4, pages 643-653.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.