Citations (155)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (11)
Ivan N. Shatsky, Sergey E. Dmitriev, Dmitri E. Andreev & Ilya M. Terenin. (2014) Transcriptome-wide studies uncover the diversity of modes of mRNA recruitment to eukaryotic ribosomes. Critical Reviews in Biochemistry and Molecular Biology 49:2, pages 164-177.
Read now
Read now
Jianling Xie & Chris G Proud. (2014) Signaling crosstalk between the mTOR complexes. Translation 2:1.
Read now
Read now
Benoit Bilanges, Rhoda Argonza-Barrett, Marina Kolesnichenko, Christina Skinner, Manoj Nair, Michelle Chen & David Stokoe. (2007) Tuberous Sclerosis Complex Proteins 1 and 2 Control Serum-Dependent Translation in a TOP-Dependent and -Independent Manner. Molecular and Cellular Biology 27:16, pages 5746-5764.
Read now
Read now
Matthew Carroll, John Dyer & Wayne S. Sossin. (2006) Serotonin Increases Phosphorylation of Synaptic 4EBP through TOR, but Eukaryotic Initiation Factor 4E Levels Do Not Limit Somatic Cap-Dependent Translation in Aplysia Neurons. Molecular and Cellular Biology 26:22, pages 8586-8598.
Read now
Read now
Daron C. Barnard, Quiping Cao & Joel D. Richter. (2005) Differential Phosphorylation Controls Maskin Association with Eukaryotic Translation Initiation Factor 4E and Localization on the Mitotic Apparatus. Molecular and Cellular Biology 25:17, pages 7605-7615.
Read now
Read now
Xuemin Wang, Anne Beugnet, Mirei Murakami, Shinya Yamanaka & Christopher G. Proud. (2005) Distinct Signaling Events Downstream of mTOR Cooperate To Mediate the Effects of Amino Acids and Insulin on Initiation Factor 4E-Binding Proteins. Molecular and Cellular Biology 25:7, pages 2558-2572.
Read now
Read now
Xuemin Wang, Wei Li, Josep-Lluis Parra, Anne Beugnet & Christopher G. Proud. (2003) The C Terminus of Initiation Factor 4E-Binding Protein 1 Contains Multiple Regulatory Features That Influence Its Function and Phosphorylation. Molecular and Cellular Biology 23:5, pages 1546-1557.
Read now
Read now
Lloyd P. McMahon, Kin M. Choi, Tai-An Lin, Robert T. Abraham & John C. Lawrence$suffix/text()$suffix/text(). (2002) The Rapamycin-Binding Domain Governs Substrate Selectivity by the Mammalian Target of Rapamycin. Molecular and Cellular Biology 22:21, pages 7428-7438.
Read now
Read now
Shunan Li, Nahum Sonenberg, Anne-Claude Gingras, Mark Peterson, Svetlana Avdulov, Vitaly A. Polunovsky & Peter B. Bitterman. (2002) Translational Control of Cell Fate: Availability of Phosphorylation Sites on Translational Repressor 4E-BP1 Governs Its Proapoptotic Potency. Molecular and Cellular Biology 22:8, pages 2853-2861.
Read now
Read now
Andrew R. Tee & Christopher G. Proud. (2002) Caspase Cleavage of Initiation Factor 4E-Binding Protein 1 Yields a Dominant Inhibitor of Cap-Dependent Translation and Reveals a Novel Regulatory Motif. Molecular and Cellular Biology 22:6, pages 1674-1683.
Read now
Read now
W. Keith Miskimins, Gang Wang, Michelle Hawkinson & Robin Miskimins. (2001) Control of Cyclin-Dependent Kinase Inhibitor p27 Expression by Cap-Independent Translation. Molecular and Cellular Biology 21:15, pages 4960-4967.
Read now
Read now
Articles from other publishers (144)
Chunxiao Liu, Ruijie Zhang, Liu Yang, Tong Ji, Cuilan Zhu, Beibei Liu, Hai Zhang, Chong Xu, Nana Zhang, Shile Huang & Long Chen. (2022) Neuroprotection of resveratrol against cadmium-poisoning acts through dual inhibition of mTORC1/2 signaling. Neuropharmacology 219, pages 109236.
Crossref
Crossref
Stefania Battaglioni, Don Benjamin, Matthias Wälchli, Timm Maier & Michael N. Hall. (2022) mTOR substrate phosphorylation in growth control. Cell 185:11, pages 1814-1836.
Crossref
Crossref
Shiyong Yang, Zhao Liu, Zhaozhan Yan, Zhongmeng Zhao, Chaoyang Zhang, Quan Gong, Xiaogang Du, Jiayun Wu, Yang Feng, Jun Du & Xiaoli Huang. (2021) Improvement of skeletal muscle growth by GH/IGF growth-axis contributes to growth performance in commercial fleshy sturgeon. Aquaculture 543, pages 736929.
Crossref
Crossref
Jian-Jun Jia, Roni M Lahr, Michael T Solgaard, Bruno J Moraes, Roberta Pointet, An-Dao Yang, Giovanna Celucci, Tyson E Graber, Huy-Dung Hoang, Marius R Niklaus, Izabella A Pena, Anne K Hollensen, Ewan M Smith, Malik Chaker-Margot, Leonie Anton, Christopher Dajadian, Mark Livingstone, Jaclyn Hearnden, Xu-Dong Wang, Yonghao Yu, Timm Maier, Christian K Damgaard, Andrea J Berman, Tommy Alain & Bruno D Fonseca. (2021) mTORC1 promotes TOP mRNA translation through site-specific phosphorylation of LARP1. Nucleic Acids Research 49:6, pages 3461-3489.
Crossref
Crossref
Lily Keane, Ignazio Antignano, Sean-Patrick Riechers, Raphael Zollinger, Anaelle A. Dumas, Nina Offermann, Maria E. Bernis, Jenny Russ, Frederike Graelmann, Patrick Neil McCormick, Julia Esser, Dario Tejera, Ai Nagano, Jun Wang, Claude Chelala, Yvonne Biederbick, Annett Halle, Paolo Salomoni, Michael T. Heneka & Melania Capasso. (2021) mTOR-dependent translation amplifies microglia priming in aging mice. Journal of Clinical Investigation 131:1.
Crossref
Crossref
Christopher G. Proud & Jianling Xie. 2021. Encyclopedia of Biological Chemistry III. Encyclopedia of Biological Chemistry III
614
630
.
Jonas R. Knudsen, Zhencheng Li, Kaspar W. Persson, Jingwen Li, Carlos Henriquez‐Olguin & Thomas E. Jensen. (2020) Contraction‐regulated mTORC1 and protein synthesis: Influence of AMPK and glycogen. The Journal of Physiology 598:13, pages 2637-2649.
Crossref
Crossref
Rui Sun, Erdong Cheng, Celestino Velásquez, Yuan Chang & Patrick S. Moore. (2019) Mitosis-related phosphorylation of the eukaryotic translation suppressor 4E-BP1 and its interaction with eukaryotic translation initiation factor 4E (eIF4E). Journal of Biological Chemistry 294:31, pages 11840-11852.
Crossref
Crossref
Silje Anda & Beáta Grallert. (2019) Cell‐Cycle‐Dependent Regulation of Translation: New Interpretations of Old Observations in Light of New Approaches. BioEssays 41:8, pages 1900022.
Crossref
Crossref
Bruno D. Fonseca, Roni M. Lahr, Christian K. Damgaard, Tommy Alain & Andrea J. Berman. (2018) LARP1 on TOP of ribosome production. WIREs RNA 9:5.
Crossref
Crossref
Qingyu Zeng, Shanshan Qin, Hai Zhang, Beibei Liu, Jiamin Qin, Xiaoxue Wang, Ruijie Zhang, Chunxiao Liu, Xiaoqing Dong, Shuangquan Zhang, Shile Huang & Long Chen. (2017) Rapamycin attenuates BAFF‐extended proliferation and survival via disruption of mTORC1/2 signaling in normal and neoplastic B‐lymphoid cells. Journal of Cellular Physiology 233:1, pages 516-529.
Crossref
Crossref
Thanh-Trang T. Vo, J. Scott Lee, Duc Nguyen, Brandon Lui, William Pandori, Andrew Khaw, Sharmila Mallya, Mengrou Lu, Markus Müschen, Marina Konopleva & David A. Fruman. (2017) mTORC1 Inhibition Induces Resistance to Methotrexate and 6-Mercaptopurine in Ph+ and Ph-like B-ALL. Molecular Cancer Therapeutics 16:9, pages 1942-1953.
Crossref
Crossref
Ilya M. Terenin, Victoria V. Smirnova, Dmitri E. Andreev, Sergey E. Dmitriev & Ivan N. Shatsky. (2016) A researcher’s guide to the galaxy of IRESs. Cellular and Molecular Life Sciences 74:8, pages 1431-1455.
Crossref
Crossref
Rachel Piddock, Kristian Bowles & Stuart Rushworth. (2017) The Role of PI3K Isoforms in Regulating Bone Marrow Microenvironment Signaling Focusing on Acute Myeloid Leukemia and Multiple Myeloma. Cancers 9:12, pages 29.
Crossref
Crossref
Fangjun Lin, Dengyue Yuan, Defang Chen & Zhiqiong Li. (2017) Eukaryotic initiation factor 4E binding protein family members are widely expressed in fish tissues: Cloning and distribution of 4E-BPs in Schizothorax prenanti. Agri Gene 3, pages 109-115.
Crossref
Crossref
Riki Ogasawara, Satoshi Fujita, Troy A. Hornberger, Yu Kitaoka, Yuhei Makanae, Koichi Nakazato & Ishii Naokata. (2016) The role of mTOR signalling in the regulation of skeletal muscle mass in a rodent model of resistance exercise. Scientific Reports 6:1.
Crossref
Crossref
Marcus MobergWilliam ApróBjörn EkblomGerrit van HallHans-Christer Holmberg & Eva Blomstrand. (2016) Activation of mTORC1 by leucine is potentiated by branched-chain amino acids and even more so by essential amino acids following resistance exercise. American Journal of Physiology-Cell Physiology 310:11, pages C874-C884.
Crossref
Crossref
Lomon SoJongdae LeeMiguel PalafoxSharmila MallyaChaz G. WoxlandMeztli ArguelloMorgan L. TruittNahum SonenbergDavide RuggeroDavid A. Fruman. (2016) The 4E-BP–eIF4E axis promotes rapamycin-sensitive growth and proliferation in lymphocytes. Science Signaling 9:430.
Crossref
Crossref
K-S Hsu, B-J Guan, X Cheng, D Guan, M Lam, M Hatzoglou & H-Y Kao. (2015) Translational control of PML contributes to TNFα-induced apoptosis of MCF7 breast cancer cells and decreased angiogenesis in HUVECs. Cell Death & Differentiation 23:3, pages 469-483.
Crossref
Crossref
Carla Schmidt, Victoria Beilsten-Edmands & Carol V. Robinson. (2016) Insights into Eukaryotic Translation Initiation from Mass Spectrometry of Macromolecular Protein Assemblies. Journal of Molecular Biology 428:2, pages 344-356.
Crossref
Crossref
Bruno D. Fonseca, Tyson E. Graber, Huy-Dung Hoang, Asier González, Alexander A. Soukas, Greco Hernández, Tommy Alain, Stephanie L. Swift, Ronit Weisman, Christian Meyer, Christophe Robaglia, Joseph Avruch & Michael N. Hall. 2016. Evolution of the Protein Synthesis Machinery and Its Regulation. Evolution of the Protein Synthesis Machinery and Its Regulation
327
411
.
Chong Xu, Chunxiao Liu, Lei Liu, Ruijie Zhang, Hai Zhang, Sujuan Chen, Yan Luo, Long Chen & Shile Huang. (2015) Rapamycin prevents cadmium-induced neuronal cell death via targeting both mTORC1 and mTORC2 pathways. Neuropharmacology 97, pages 35-45.
Crossref
Crossref
Naotaka Sekiyama, Haribabu Arthanari, Evangelos Papadopoulos, Ricard A. Rodriguez-Mias, Gerhard Wagner & Mélissa Léger-Abraham. (2015) Molecular mechanism of the dual activity of 4EGI-1: Dissociating eIF4G from eIF4E but stabilizing the binding of unphosphorylated 4E-BP1. Proceedings of the National Academy of Sciences 112:30.
Crossref
Crossref
Mark Livingstone, Kristina Sikström, Philippe A. Robert, Gilles Uzé, Ola Larsson & Sandra Pellegrini. (2015) Assessment of mTOR-Dependent Translational Regulation of Interferon Stimulated Genes. PLOS ONE 10:7, pages e0133482.
Crossref
Crossref
Hou-Gang Huang, Xi Luo, Shuai Wu & Bin Jian. (2015) MiR-99a Inhibits Cell Proliferation and Tumorigenesis through Targeting mTOR in Human Anaplastic Thyroid Cancer. Asian Pacific Journal of Cancer Prevention 16:12, pages 4937-4944.
Crossref
Crossref
Long Chen, Baoshan Xu, Lei Liu, Chunxiao Liu, Yan Luo, Xin Chen, Mansoureh Barzegar, Jun Chung & Shile Huang. (2015) Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion. Oncotarget 6:9, pages 7136-7150.
Crossref
Crossref
Marie-Jo Halaby, Yan Li, Benjamin R. Harris, Shuxia Jiang, W. Keith Miskimins, Margot P. Cleary & Da-Qing Yang. (2015) Translational Control Protein 80 Stimulates IRES-Mediated Translation of p53 mRNA in Response to DNA Damage. BioMed Research International 2015, pages 1-9.
Crossref
Crossref
Bei Lan, Ya-Juan Wan, Shuang Pan, Yu Wang, Yin Yang, Qian-Li Leng, Huiyan Jia, Yao-hui Liu, Cui-Zhu Zhang & Youjia Cao. (2015) Parthenolide induces autophagy via the depletion of 4E-BP1. Biochemical and Biophysical Research Communications 456:1, pages 434-439.
Crossref
Crossref
Atef Nehdi, Polen Sean, Izzar Linares, Rodney Colina, Maritza Jaramillo & Tommy Alain. (2014) Deficiency in Either 4E-BP1 or 4E-BP2 Augments Innate Antiviral Immune Responses. PLoS ONE 9:12, pages e114854.
Crossref
Crossref
Ahmed M. Osman & Henk van Loveren. (2014) The immunosuppressant tributyltin oxide blocks the mTOR pathway, like rapamycin, albeit by a different mechanism. Journal of Applied Toxicology 34:12, pages 1361-1367.
Crossref
Crossref
Jennifer L. Steiner & Charles H. Lang. (2014) Alcohol impairs skeletal muscle protein synthesis and mTOR signaling in a time-dependent manner following electrically stimulated muscle contraction. Journal of Applied Physiology 117:10, pages 1170-1179.
Crossref
Crossref
Franck C. Courtes, Leah Vardy, Niki S.C. Wong, Muriel Bardor, Miranda G.S. Yap & Dong-Yup Lee. (2014) Understanding translational control mechanisms of the mTOR pathway in CHO cells by polysome profiling. New Biotechnology 31:5, pages 514-523.
Crossref
Crossref
Yoshinori Tsukumo, Mathieu Laplante, Armen Parsyan, Davide Ruggero & Bruno Fonseca. 2014. Translation and Its Regulation in Cancer Biology and Medicine. Translation and Its Regulation in Cancer Biology and Medicine
307
343
.
Angelos K. Sikalidis, Kevin M. Mazor, Minji Kang, Hongyun Liu & Martha H. Stipanuk. (2013) Total 4EBP1 Is Elevated in Liver of Rats in Response to Low Sulfur Amino Acid Intake. Journal of Amino Acids 2013, pages 1-11.
Crossref
Crossref
Yang Liu, Didier Vertommen, Mark H. Rider & Yu-Chiang Lai. (2013) Mammalian target of rapamycin-independent S6K1 and 4E-BP1 phosphorylation during contraction in rat skeletal muscle. Cellular Signalling 25:9, pages 1877-1886.
Crossref
Crossref
Michael PourdehnadMorgan L. TruittImran N. SiddiqiGregory S. Ducker, Kevan M. Shokat & Davide Ruggero. (2013) Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers. Proceedings of the National Academy of Sciences 110:29, pages 11988-11993.
Crossref
Crossref
Wei Du, Yong Yi, Haibo Zhang, Johann Bergholz, Junfeng Wu, Haoqiang Ying, Yujun Zhang & Zhi-Xiong Jim Xiao. (2013) Rapamycin Inhibits IGF-1-Mediated Up-Regulation of MDM2 and Sensitizes Cancer Cells to Chemotherapy. PLoS ONE 8:4, pages e63179.
Crossref
Crossref
Jordi Rodon, Rodrigo Dienstmann, Violeta Serra & Josep Tabernero. (2013) Development of PI3K inhibitors: lessons learned from early clinical trials. Nature Reviews Clinical Oncology 10:3, pages 143-153.
Crossref
Crossref
Erin N. Hodges & John H. Connor. (2013) Translational control by negative-strand RNA viruses: Methods for the study of a crucial virus/host interaction. Methods 59:2, pages 180-187.
Crossref
Crossref
Ko-yi Chien, Kevin Blackburn, Hsiao-Ching Liu & Michael B. Goshe. (2012) Proteomic and Phosphoproteomic Analysis of Chicken Embryo Fibroblasts Infected with Cell Culture-Attenuated and Vaccine Strains of Marek’s Disease Virus. Journal of Proteome Research 11:12, pages 5663-5677.
Crossref
Crossref
Aiko Kume, Damdinsuren Boldbaatar, Yuko Takazawa, Rika Umemiya-Shirafuji, Tetsuya Tanaka & Kozo Fujisaki. (2012) RNAi of the translation inhibition gene 4E-BP identified from the hard tick, Haemaphysalis longicornis, affects lipid storage during the off-host starvation period of ticks. Parasitology Research 111:2, pages 889-896.
Crossref
Crossref
Mark Livingstone & Michael Bidinosti. (2012) Rapamycin-insensitive mTORC1 activity controls eIF4E:4E-BP1 binding. F1000Research 1, pages 4.
Crossref
Crossref
Isabel M. González, Patrick M. Martin, Carol Burdsal, Jennifer L. Sloan, Sela Mager, Thurl Harris & Ann E. Sutherland. (2012) Leucine and arginine regulate trophoblast motility through mTOR-dependent and independent pathways in the preimplantation mouse embryo. Developmental Biology 361:2, pages 286-300.
Crossref
Crossref
Sampoorna Satheesha, Victoria J Cookson, Louise J Coleman, Nicola Ingram, Brijesh Madhok, Andrew M Hanby, Charlotte AB Suleman, Vicky S Sabine, E Jane Macaskill, John MS Bartlett, J Michael Dixon, Jim N McElwaine & Thomas A Hughes. (2011) Response to mTOR inhibition: activity of eIF4E predicts sensitivity in cell lines and acquired changes in eIF4E regulation in breast cancer. Molecular Cancer 10:1.
Crossref
Crossref
Jae Hong No, Yong-Tark Jeon, In-Ae Park, Yong-Beom Kim, Jae Weon Kim, Noh-Hyun Park, Soon-Beom Kang, Jae Yong Han, Jeong Mook Lim & Yong-Sang Song. (2011) Activation of mTOR signaling pathway associated with adverse prognostic factors of epithelial ovarian cancer. Gynecologic Oncology 121:1, pages 8-12.
Crossref
Crossref
Eduardo Vilar, Jose Perez-Garcia & Josep Tabernero. (2011) Pushing the Envelope in the mTOR Pathway: The Second Generation of Inhibitors. Molecular Cancer Therapeutics 10:3, pages 395-403.
Crossref
Crossref
Prashanthi Karyala, Nima D. Namsa & Durga Rao Chilakalapudi. (2010) Translational Up-Regulation and High-Level Protein Expression from Plasmid Vectors by mTOR Activation via Different Pathways in PC3 and 293T Cells. PLoS ONE 5:12, pages e14408.
Crossref
Crossref
Andrew G. Cridge, Lydia M. Castelli, Julia B. Smirnova, Julian N. Selley, William Rowe, Simon J. Hubbard, John E.G. McCarthy, Mark P. Ashe, Christopher M. Grant & Graham D. Pavitt. (2010) Identifying eIF4E-binding protein translationally-controlled transcripts reveals links to mRNAs bound by specific PUF proteins. Nucleic Acids Research 38:22, pages 8039-8050.
Crossref
Crossref
María I. Ayuso, Macarena Hernández-Jiménez, María E. Martín, Matilde Salinas & Alberto Alcázar. (2010) New Hierarchical Phosphorylation Pathway of the Translational Repressor eIF4E-binding Protein 1 (4E-BP1) in Ischemia-Reperfusion Stress. Journal of Biological Chemistry 285:45, pages 34355-34363.
Crossref
Crossref
Denghong Zhang, Riccardo Contu, Michael V.G. Latronico, Jian Ling Zhang, Roberto Rizzi, Daniele Catalucci, Shigeki Miyamoto, Katherine Huang, Marcello Ceci, Yusu Gu, Nancy D. Dalton, Kirk L. Peterson, Kun-Liang Guan, Joan Heller Brown, Ju Chen, Nahum Sonenberg & Gianluigi Condorelli. (2010) MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice. Journal of Clinical Investigation 120:8, pages 2805-2816.
Crossref
Crossref
Michael Bidinosti, Israeli Ran, Maria R. Sanchez-Carbente, Yvan Martineau, Anne-Claude Gingras, Christos Gkogkas, Brian Raught, Clive R. Bramham, Wayne S. Sossin, Mauro Costa-Mattioli, Luc DesGroseillers, Jean-Claude Lacaille & Nahum Sonenberg. (2010) Postnatal Deamidation of 4E-BP2 in Brain Enhances Its Association with Raptor and Alters Kinetics of Excitatory Synaptic Transmission. Molecular Cell 37:6, pages 797-808.
Crossref
Crossref
Andrew C. Hsieh, Maria Costa, Ornella Zollo, Cole Davis, Morris E. Feldman, Joseph R. Testa, Oded Meyuhas, Kevan M. Shokat & Davide Ruggero. (2010) Genetic Dissection of the Oncogenic mTOR Pathway Reveals Druggable Addiction to Translational Control via 4EBP-eIF4E. Cancer Cell 17:3, pages 249-261.
Crossref
Crossref
Priam Villalonga, Silvia Fernández de Mattos & Anne J. Ridley. (2009) RhoE Inhibits 4E-BP1 Phosphorylation and eIF4E Function Impairing Cap-dependent Translation. Journal of Biological Chemistry 284:51, pages 35287-35296.
Crossref
Crossref
Juan A. Arroyo, Laura D. Brown & Henry L. Galan. (2009) Placental mammalian target of rapamycin and related signaling pathways in an ovine model of intrauterine growth restriction. American Journal of Obstetrics and Gynecology 201:6, pages 616.e1-616.e7.
Crossref
Crossref
Dmitri E. Andreev, Sergey E. Dmitriev, Ilya M. Terenin, Vladimir S. Prassolov, William C. Merrick & Ivan N. Shatsky. (2009) Differential contribution of the m7G-cap to the 5′ end-dependent translation initiation of mammalian mRNAs. Nucleic Acids Research 37:18, pages 6135-6147.
Crossref
Crossref
Mark Willett, Joanne L. Cowan, Markete Vlasak, Mark J. Coldwell & Simon J. Morley. (2009) Inhibition of mammalian target of rapamycin (mTOR) signalling in C2C12 myoblasts prevents myogenic differentiation without affecting the hyperphosphorylation of 4E-BP1. Cellular Signalling 21:10, pages 1504-1512.
Crossref
Crossref
Yubao Wang, Louis M. Weiss & Amos Orlofsky. (2009)
Intracellular parasitism with
Toxoplasma gondii
stimulates mammalian-target-of-rapamycin-dependent host cell growth despite impaired signalling to S6K1 and 4E-BP1
. Cellular Microbiology 11:6, pages 983-1000.
Crossref
Crossref
J. Werzowa, D. Cejka, T. Fuereder, B. Dekrout, C. Thallinger, H. Pehamberger, V. Wacheck & B. Pratscher. (2009) Suppression of mTOR complex 2-dependent AKT phosphorylation in melanoma cells by combined treatment with rapamycin and LY294002. British Journal of Dermatology 160:5, pages 955-964.
Crossref
Crossref
Tatsuhiro Sato, Akio Nakashima, Lea Guo & Fuyuhiko Tamanoi. (2009) Specific Activation of mTORC1 by Rheb G-protein in Vitro Involves Enhanced Recruitment of Its Substrate Protein. Journal of Biological Chemistry 284:19, pages 12783-12791.
Crossref
Crossref
Laura D. Brown, Paul J. Rozance, James S. Barry, Jacob E. Friedman & William W. HayJr.Jr.. (2009) Insulin is required for amino acid stimulation of dual pathways for translational control in skeletal muscle in the late-gestation ovine fetus. American Journal of Physiology-Endocrinology and Metabolism 296:1, pages E56-E63.
Crossref
Crossref
Bruno D. Fonseca & Christopher G. Proud. 2010. mTOR Pathway and mTOR Inhibitors in Cancer Therapy. mTOR Pathway and mTOR Inhibitors in Cancer Therapy
179
200
.
L Liu, L Chen, J Chung & S Huang. (2008) Rapamycin inhibits F-actin reorganization and phosphorylation of focal adhesion proteins. Oncogene 27:37, pages 4998-5010.
Crossref
Crossref
Liwei Rong, Mark Livingstone, Rami Sukarieh, Emmanuel Petroulakis, Anne-Claude Gingras, Katherine Crosby, Bradley Smith, Roberto D. Polakiewicz, Jerry Pelletier, Maria A. Ferraiuolo & Nahum Sonenberg. (2008) Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPs. RNA 14:7, pages 1318-1327.
Crossref
Crossref
Iban Seiliez, Jean-Charles Gabillard, Sandrine Skiba-Cassy, Daniel Garcia-Serrana, Joaquim Gutiérrez, Sadasivam Kaushik, Stephane Panserat & Sophie Tesseraud. (2008)
An in vivo and in vitro assessment of TOR signaling cascade in rainbow trout (
Oncorhynchus mykiss
)
. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 295:1, pages R329-R335.
Crossref
Crossref
Ruifeng Cao, Boyoung Lee, Hee-yeon Cho, Sanjida Saklayen & Karl Obrietan. (2008) Photic regulation of the mTOR signaling pathway in the suprachiasmatic circadian clock. Molecular and Cellular Neuroscience 38:3, pages 312-324.
Crossref
Crossref
Jingxiang HuangBrendan D. Manning. (2008) The TSC1–TSC2 complex: a molecular switchboard controlling cell growth. Biochemical Journal 412:2, pages 179-190.
Crossref
Crossref
Vivian H. Y. Lee, Timothy Healy, Bruno D. Fonseca, Amanda Hayashi & Christopher G. Proud. (2008) Analysis of the regulatory motifs in eukaryotic initiation factor 4E-binding protein 1. FEBS Journal 275:9, pages 2185-2199.
Crossref
Crossref
M. Celeste SimonLiping LiuBryan C. BarnhartRegina M. Young. (2008) Hypoxia-Induced Signaling in the Cardiovascular System. Annual Review of Physiology 70:1, pages 51-71.
Crossref
Crossref
Idoia Burgui, Emilio Yángüez, Nahum Sonenberg & Amelia Nieto. (2007) Influenza Virus mRNA Translation Revisited: Is the eIF4E Cap-Binding Factor Required for Viral mRNA Translation?. Journal of Virology 81:22, pages 12427-12438.
Crossref
Crossref
Ola Larsson, Shunan Li, Olga A. Issaenko, Svetlana Avdulov, Mark Peterson, Karen Smith, Peter B. Bitterman & Vitaly A. Polunovsky. (2007) Eukaryotic Translation Initiation Factor 4E–Induced Progression of Primary Human Mammary Epithelial Cells along the Cancer Pathway Is Associated with Targeted Translational Deregulation of Oncogenic Drivers and Inhibitors. Cancer Research 67:14, pages 6814-6824.
Crossref
Crossref
Lifu Wang, Thurl E. Harris, Richard A. Roth & John C. LawrenceJrJr. (2007) PRAS40 Regulates mTORC1 Kinase Activity by Functioning as a Direct Inhibitor of Substrate Binding. Journal of Biological Chemistry 282:27, pages 20036-20044.
Crossref
Crossref
Marie-Jo Halaby & Da-Qing Yang. (2007) p53 translational control: A new facet of p53 regulation and its implication for tumorigenesis and cancer therapeutics. Gene 395:1-2, pages 1-7.
Crossref
Crossref
Lingjie Guan, Kyung Song, Marybeth A. Pysz, Kathryn J. Curry, A. Asli Hizli, David Danielpour, Adrian R. Black & Jennifer D. Black. (2007) Protein Kinase C-mediated Down-regulation of Cyclin D1 Involves Activation of the Translational Repressor 4E-BP1 via a Phosphoinositide 3-Kinase/Akt-independent, Protein Phosphatase 2A-dependent Mechanism in Intestinal Epithelial Cells. Journal of Biological Chemistry 282:19, pages 14213-14225.
Crossref
Crossref
Alan R. Saltiel & Jeffrey E. PessinJoseph F. Christian & John C. LawrenceJr.Jr.. 2007. Mechanisms of Insulin Action. Mechanisms of Insulin Action
71
89
.
M. Salinas & J. Burda. 2007. Handbook of Neurochemistry and Molecular Neurobiology. Handbook of Neurochemistry and Molecular Neurobiology
1
33
.
L Liu, F Li, J A Cardelli, K A Martin, J Blenis & S Huang. (2006) Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways. Oncogene 25:53, pages 7029-7040.
Crossref
Crossref
J Averous & C G Proud. (2006) When translation meets transformation: the mTOR story. Oncogene 25:48, pages 6423-6435.
Crossref
Crossref
Laura S. Spruill, Paul J. McDermott, Laura S. Spruill & Paul J. McDermott. (2006) Regulation of c‐jun mRNA expression in adult cardiocytes by MAP kinase interacting kinase‐1 (MNK1). The FASEB Journal 20:12, pages 2133-2135.
Crossref
Crossref
D-Q Yang, M-J Halaby & Y Zhang. (2006) The identification of an internal ribosomal entry site in the 5′-untranslated region of p53 mRNA provides a novel mechanism for the regulation of its translation following DNA damage. Oncogene 25:33, pages 4613-4619.
Crossref
Crossref
Vivienne Tilleray, Constantina Constantinou & Michael J. Clemens. (2006) Regulation of protein synthesis by inducible wild-type p53 in human lung carcinoma cells. FEBS Letters 580:7, pages 1766-1770.
Crossref
Crossref
Huajun Yan, Patrick Frost, Yijiang Shi, Bao Hoang, Sanjai Sharma, Myrna Fisher, Joseph Gera & Alan Lichtenstein. (2006) Mechanism by Which Mammalian Target of Rapamycin Inhibitors Sensitize Multiple Myeloma Cells to Dexamethasone-Induced Apoptosis. Cancer Research 66:4, pages 2305-2313.
Crossref
Crossref
A. O'Loghlen, M.I. Pérez-Morgado, M. Salinas & M.E. Martín. (2006) N-acetyl-cysteine abolishes hydrogen peroxide-induced modification of eukaryotic initiation factor 4F activity via distinct signalling pathways. Cellular Signalling 18:1, pages 21-31.
Crossref
Crossref
Wei Yue, Jiping Wang, Yuebai Li, Ping Fan & Richard J. Santen. (2005) Farnesylthiosalicylic acid blocks mammalian target of rapamycin signaling in breast cancer cells. International Journal of Cancer 117:5, pages 746-754.
Crossref
Crossref
Davide Ruggero & Nahum Sonenberg. (2005) The Akt of translational control. Oncogene 24:50, pages 7426-7434.
Crossref
Crossref
Takayuki Murata, Makoto Hijikata & Kunitada Shimotohno. (2005) Enhancement of internal ribosome entry site-mediated translation and replication of hepatitis C virus by PD98059. Virology 340:1, pages 105-115.
Crossref
Crossref
Constantina Constantinou & Michael J Clemens. (2005) Regulation of the phosphorylation and integrity of protein synthesis initiation factor eIF4GI and the translational repressor 4E-BP1 by p53. Oncogene 24:30, pages 4839-4850.
Crossref
Crossref
Victoria L Greenberg & Stephen G Zimmer. (2005) Paclitaxel induces the phosphorylation of the eukaryotic translation initiation factor 4E-binding protein 1 through a Cdk1-dependent mechanism. Oncogene 24:30, pages 4851-4860.
Crossref
Crossref
W.E. Colpoys, B.H. Cochran, Tessa M. Carducci & C.M. Thorpe. (2005) Shiga toxins activate translational regulation pathways in intestinal epithelial cells. Cellular Signalling 17:7, pages 891-899.
Crossref
Crossref
Jeffrey S. Shenberger, Jennifer L. Myers, Stephen G. Zimmer, Richard J. Powell & Aaron Barchowsky. (2005) Hyperoxia alters the expression and phosphorylation of multiple factors regulating translation initiation. American Journal of Physiology-Lung Cellular and Molecular Physiology 288:3, pages L442-L449.
Crossref
Crossref
Ken Inoki, Hongjiao Ouyang, Yong Li & Kun-Liang Guan. (2005) Signaling by Target of Rapamycin Proteins in Cell Growth Control. Microbiology and Molecular Biology Reviews 69:1, pages 79-100.
Crossref
Crossref
Z. D. Sharp & A. Bartke. (2005) Evidence for Down-Regulation of Phosphoinositide 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR)-Dependent Translation Regulatory Signaling Pathways in Ames Dwarf Mice. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 60:3, pages 293-300.
Crossref
Crossref
Neil Kubica, Douglas R. Bolster, Peter A. Farrell, Scot R. Kimball & Leonard S. Jefferson. (2005) Resistance Exercise Increases Muscle Protein Synthesis and Translation of Eukaryotic Initiation Factor 2Bϵ mRNA in a Mammalian Target of Rapamycin-dependent Manner. Journal of Biological Chemistry 280:9, pages 7570-7580.
Crossref
Crossref
Edith Gomez, Michael L. Powell, Isabel C. Greenman & Terence P. Herbert. (2004) Glucose-stimulated Protein Synthesis in Pancreatic β-Cells Parallels an Increase in the Availability of the Translational Ternary Complex (eIF2-GTP·Met-tRNAi) and the Dephosphorylation of eIF2α. Journal of Biological Chemistry 279:52, pages 53937-53946.
Crossref
Crossref
Hyun Woo Kim, In Kyu Park, Chong Su Cho, Kee Ho Lee, George R. BeckJr.Jr., Nancy H. Colburn & Myung Haing Cho. (2004)
Aerosol Delivery of Glucosylated Polyethylenimine/Phosphatase and Tensin Homologue Deleted on Chromosome 10 Complex Suppresses Akt Downstream Pathways in the Lung of K-
ras
Null Mice
. Cancer Research 64:21, pages 7971-7976.
Crossref
Crossref
Maria Dolors Sans, Sae-Hong Lee, Louis G. D'Alecy & John A. Williams. (2004) Feeding activates protein synthesis in mouse pancreas at the translational level without increase in mRNA. American Journal of Physiology-Gastrointestinal and Liver Physiology 287:3, pages G667-G675.
Crossref
Crossref
Nissim Hay & Nahum Sonenberg. (2004) Upstream and downstream of mTOR. Genes & Development 18:16, pages 1926-1945.
Crossref
Crossref
Maria Dolors Sans & John A. Williams. (2004) Calcineurin is required for translational control of protein synthesis in rat pancreatic acini. American Journal of Physiology-Cell Physiology 287:2, pages C310-C319.
Crossref
Crossref
Bhavesh Joshi, Amy Cameron & Rosemary Jagus. (2004) Characterization of mammalian eIF4E-family members. European Journal of Biochemistry 271:11, pages 2189-2203.
Crossref
Crossref
Svetlana Avdulov, Shunan Li, Van Michalek, David Burrichter, Mark Peterson, David M Perlman, J.Carlos Manivel, Nahum Sonenberg, Douglas Yee, Peter B Bitterman & Vitaly A Polunovsky. (2004) Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells. Cancer Cell 5:6, pages 553-563.
Crossref
Crossref
Lazaros C Foukas & Peter R Shepherd. (2004) eIF4E binding protein 1 and H-Ras are novel substrates for the protein kinase activity of class-I phosphoinositide 3-kinase. Biochemical and Biophysical Research Communications 319:2, pages 541-549.
Crossref
Crossref
Mary-Ann Bjornsti & Peter J. Houghton. (2004) The tor pathway: a target for cancer therapy. Nature Reviews Cancer 4:5, pages 335-348.
Crossref
Crossref
Diane C Fingar & John Blenis. (2004) Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 23:18, pages 3151-3171.
Crossref
Crossref
Christopher G. Proud. (2004) mTOR-mediated regulation of translation factors by amino acids. Biochemical and Biophysical Research Communications 313:2, pages 429-436.
Crossref
Crossref
R. T. Abraham. 2004. TOR. TOR
299
319
.
J. C. Lawrence, T.-A. Lin, L. P. McMahon & K. M. Choi. 2004. TOR. TOR
199
213
.
Thurl E. HarrisJohn C. LawrenceJr.Jr.. (2003) TOR Signaling. Science's STKE 2003:212.
Crossref
Crossref
Gail Ferguson, Isabelle Mothe-Satney & John C. LawrenceJr.Jr.. (2003) Ser-64 and Ser-111 in PHAS-I Are Dispensable for Insulin-stimulated Dissociation from eIF4E. Journal of Biological Chemistry 278:48, pages 47459-47465.
Crossref
Crossref
Anne Beugnet, Xuemin Wang & Christopher G. Proud. (2003) Target of Rapamycin (TOR)-signaling and RAIP Motifs Play Distinct Roles in the Mammalian TOR-dependent Phosphorylation of Initiation Factor 4E-binding Protein 1. Journal of Biological Chemistry 278:42, pages 40717-40722.
Crossref
Crossref
Indira Neeli, Chandrahasa R Yellaturu & Gadiparthi N Rao. (2003) Arachidonic acid activation of translation initiation signaling in vascular smooth muscle cells. Biochemical and Biophysical Research Communications 309:4, pages 755-761.
Crossref
Crossref
Maria Dolors Sans, Matthew J. DiMagno, Louis G. D'Alecy & John A. Williams. (2003) Caerulein-induced acute pancreatitis inhibits protein synthesis through effects on eIF2B and eIF4F. American Journal of Physiology-Gastrointestinal and Liver Physiology 285:3, pages G517-G528.
Crossref
Crossref
Duraisamy Senthil, Goutam Ghosh Choudhury, Colby Mclaurin & Balakuntalam S. Kasinath. (2003) Vascular endothelial growth factor induces protein synthesis in renal epithelial cells: A potential role in diabetic nephropathy11See Editorial by Ziyadeh and Wolf, p. 758.. Kidney International 64:2, pages 468-479.
Crossref
Crossref
Kin Man Choi, Lloyd P. McMahon & John C. LawrenceJr.Jr.. (2003) Two Motifs in the Translational Repressor PHAS-I Required for Efficient Phosphorylation by Mammalian Target of Rapamycin and for Recognition by Raptor. Journal of Biological Chemistry 278:22, pages 19667-19673.
Crossref
Crossref
Wen Long, Eugene J. Barrett, Liping Wei & Zhenqi Liu. (2003) Adrenalectomy enhances the insulin sensitivity of muscle protein synthesis. American Journal of Physiology-Endocrinology and Metabolism 284:1, pages E102-E109.
Crossref
Crossref
Nobuhiro Takahashi. 2003. Macrolide Antibiotics. Macrolide Antibiotics
577
621
.
Tobias Schmelzle, José L. Crespo & Michael N. Hall. 2003. Handbook of Cell Signaling. Handbook of Cell Signaling
299
303
.
John H. Connor & Douglas S. Lyles. (2002) Vesicular Stomatitis Virus Infection Alters the eIF4F Translation Initiation Complex and Causes Dephosphorylation of the eIF4E Binding Protein 4E-BP1. Journal of Virology 76:20, pages 10177-10187.
Crossref
Crossref
Lynn E Horton, Martin Bushell, Diane Barth-Baus, Vivienne J Tilleray, Michael J Clemens & Jack O Hensold. (2002) p53 activation results in rapid dephosphorylation of the eIF4E-binding protein 4E-BP1, inhibition of ribosomal protein S6 kinase and inhibition of translation initiation. Oncogene 21:34, pages 5325-5334.
Crossref
Crossref
Jashmin Patel, Laura E. McLeod, Robert G. J. Vries, Andrea Flynn, Xuemin Wang & Christopher G. Proud. (2002) Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors. European Journal of Biochemistry 269:12, pages 3076-3085.
Crossref
Crossref
Anna Niedzwiecka, Joseph Marcotrigiano, Janusz Stepinski, Marzena Jankowska-Anyszka, Aleksandra Wyslouch-Cieszynska, Michal Dadlez, Anne-Claude Gingras, Pawel Mak, Edward Darzynkiewicz, Nahum Sonenberg, Stephen K. Burley & Ryszard Stolarski. (2002) Biophysical Studies of eIF4E Cap-binding Protein: Recognition of mRNA 5′ Cap Structure and Synthetic Fragments of eIF4G and 4E-BP1 Proteins. Journal of Molecular Biology 319:3, pages 615-635.
Crossref
Crossref
Joshua C. Anthony, Charles H. Lang, Stephen J. Crozier, Tracy G. Anthony, David A. MacLean, Scot R. Kimball & Leonard S. Jefferson. (2002) Contribution of insulin to the translational control of protein synthesis in skeletal muscle by leucine. American Journal of Physiology-Endocrinology and Metabolism 282:5, pages E1092-E1101.
Crossref
Crossref
Thomas H. ReynoldsIVIV, Sue C. Bodine & John C. LawrenceJr.Jr.. (2002) Control of Ser2448 Phosphorylation in the Mammalian Target of Rapamycin by Insulin and Skeletal Muscle Load. Journal of Biological Chemistry 277:20, pages 17657-17662.
Crossref
Crossref
Michael B. Dilling, Glen S. Germain, Lorina Dudkin, Arun L. Jayaraman, Xiongwen Zhang, Franklin C. Harwood & Peter J. Houghton. (2002) 4E-binding Proteins, the Suppressors of Eukaryotic Initiation Factor 4E, Are Down-regulated in Cells with Acquired or Intrinsic Resistance to Rapamycin. Journal of Biological Chemistry 277:16, pages 13907-13917.
Crossref
Crossref
Terence P. Herbert, Andrew R. Tee & Christopher G. Proud. (2002) The Extracellular Signal-regulated Kinase Pathway Regulates the Phosphorylation of 4E-BP1 at Multiple Sites. Journal of Biological Chemistry 277:13, pages 11591-11596.
Crossref
Crossref
Celia Quevedo, Matilde Salinas & Alberto Alcázar. (2002) Regulation of Cap-Dependent Translation by Insulin-like Growth Factor-1 in Neuronal Cells. Biochemical and Biophysical Research Communications 291:3, pages 560-566.
Crossref
Crossref
Thomas E. Dever. (2002) Gene-Specific Regulation by General Translation Factors. Cell 108:4, pages 545-556.
Crossref
Crossref
Kathleen A. Martin & John Blenis. 2002.
1
39
.
Shile Huang & Peter J. Houghton. (2001) Mechanisms of resistance to rapamycins. Drug Resistance Updates 4:6, pages 378-391.
Crossref
Crossref
Anne-Claude Gingras, Brian Raught, Steven P. Gygi, Anna Niedzwiecka, Mathieu Miron, Stephen K. Burley, Roberto D. Polakiewicz, Aleksandra Wyslouch-Cieszynska, Ruedi Aebersold & Nahum Sonenberg. (2001) Hierarchical phosphorylation of the translation inhibitor 4E-BP1. Genes & Development 15:21, pages 2852-2864.
Crossref
Crossref
Robert T. Abraham. (2001) Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes & Development 15:17, pages 2177-2196.
Crossref
Crossref
Leonard S. Jefferson & Scot R. Kimball. (2001) Amino Acid Regulation of Gene Expression. The Journal of Nutrition 131:9, pages 2460S-2466S.
Crossref
Crossref
Kate J. Heesom, Alexandra Gampel, Harry Mellor & Richard M. Denton. (2001) Cell cycle-dependent phosphorylation of the translational repressor eIF-4E binding protein-1 (4E-BP1). Current Biology 11:17, pages 1374-1379.
Crossref
Crossref
M.J. Clemens. (2001) Translational regulation in cell stress and apoptosis. Roles of the eIF4E binding proteins. Journal of Cellular and Molecular Medicine 5:3, pages 221-239.
Crossref
Crossref
Brian Raught, Anne-Claude Gingras & Nahum Sonenberg. (2001) The target of rapamycin (TOR) proteins. Proceedings of the National Academy of Sciences 98:13, pages 7037-7044.
Crossref
Crossref
Gustavo A. Nader & Karyn A. Esser. (2001) Intracellular signaling specificity in skeletal muscle in response to different modes of exercise. Journal of Applied Physiology 90:5, pages 1936-1942.
Crossref
Crossref
Anne-Claude Gingras, Brian Raught & Nahum Sonenberg. (2001) Regulation of translation initiation by FRAP/mTOR. Genes & Development 15:7, pages 807-826.
Crossref
Crossref
Ya-Ping Jiang, Lisa M. Ballou & Richard Z. Lin. (2001) Rapamycin-insensitive Regulation of 4E-BP1 in Regenerating Rat Liver. Journal of Biological Chemistry 276:14, pages 10943-10951.
Crossref
Crossref
Muhammad Manjurul Karim, John M.X. Hughes, Jim Warwicker, Gert C. Scheper, Christopher G. Proud & John E.G. McCarthy. (2001) A Quantitative Molecular Model for Modulation of Mammalian Translation by the eIF4E-binding Protein 1. Journal of Biological Chemistry 276:23, pages 20750-20757.
Crossref
Crossref
Joseph Avruch, Christopher Belham, Qing-Peng Weng, Kenta Hara & Kazuyoshi Yonezawa. 2001. Signaling Pathways for Translation. Signaling Pathways for Translation
115
154
.
Jolinda A. Traugh. 2001. Signaling Pathways for Translation. Signaling Pathways for Translation
33
48
.
John C. LawrenceJr.Jr. & Gregory J. Brunn. 2001. Signaling Pathways for Translation. Signaling Pathways for Translation
1
31
.
Da-Qing Yang & Michael B. Kastan. (2000) Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1. Nature Cell Biology 2:12, pages 893-898.
Crossref
Crossref
Ronald Sosnowski, Pamela L. Mellon & Mark A. Lawson. (2000) Activation of Translation in Pituitary Gonadotrope Cells by Gonadotropin-Releasing Hormone. Molecular Endocrinology 14:11, pages 1811-1819.
Crossref
Crossref
O. Jameel Shah, Joshua C. Anthony, Scot R. Kimball & Leonard S. Jefferson. (2000) 4E-BP1 and S6K1: translational integration sites for nutritional and hormonal information in muscle. American Journal of Physiology-Endocrinology and Metabolism 279:4, pages E715-E729.
Crossref
Crossref
Isabelle Mothe-Satney, Gregory J. Brunn, Lloyd P. McMahon, Christopher T. Capaldo, Robert T. Abraham & John C. LawrenceJr.Jr.. (2000) Mammalian Target of Rapamycin-dependent Phosphorylation of PHAS-I in Four (S/T)P Sites Detected by Phospho-specific Antibodies. Journal of Biological Chemistry 275:43, pages 33836-33843.
Crossref
Crossref