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Molecular and Cellular Biology Volume 20, 2000 - Issue 11
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Gene Expression

A 5′ Splice Site-Proximal Enhancer Binds SF1 and Activates Exon Bridging of a Microexon

Troy Carlo1 Verna and Marrs McLean Department of Biochemistry;2 Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas77030
,
Rebecca Sierra1 Verna and Marrs McLean Department of Biochemistry
&
Susan M. Berget1 Verna and Marrs McLean Department of Biochemistry;2 Program in Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas77030Correspondence[email protected]
Pages 3988-3995 | Received 14 Jul 1999, Accepted 15 Mar 2000, Published online: 28 Mar 2023

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Ashton Curry-Hyde, Bei Jun Chen, James D. Mills & Michael Janitz. (2018) Microexons: novel regulators of the transcriptome. Journal of Human Transcriptome 2:1, pages 1-6.
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Sònia Guil, Renata Gattoni, Montserrat Carrascal, Joaquín Abián, James Stévenin & Montse Bach-Elias. (2003) Roles of hnRNP A1, SR Proteins, and p68 Helicase in c-H-ras Alternative Splicing Regulation. Molecular and Cellular Biology 23:8, pages 2927-2941.
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Hadas Peled-Zehavi, J. Andrew Berglund, Michael Rosbash & Alan D. Frankel. (2001) Recognition of RNA Branch Point Sequences by the KH Domain of Splicing Factor 1 (Mammalian Branch Point Binding Protein) in a Splicing Factor Complex. Molecular and Cellular Biology 21:15, pages 5232-5241.
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Articles from other publishers (39)

Eunjin Koh, Daye Shin & Kyung-Sup Kim. (2023) Exon definitive regions for MPC1 microexon splicing and its usage for splicing modulation. Molecular Therapy - Nucleic Acids 31, pages 398-410.
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Igor Vořechovský. (2022) Selection of Olduvai Domains during Evolution: A Role for Primate-Specific Splicing Super-Enhancer and RNA Guanine Quadruplex in Bipartite NBPF Exons. Brain Sciences 12:7, pages 874.
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Jee‐San Lee, Nathalie Lamarche‐Vane & Stéphane Richard. (2021) Microexon alternative splicing of small GTPase regulators: Implication in central nervous system diseases . WIREs RNA 13:2.
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Huihui Yu, Mu Li, Jaspreet Sandhu, Guangchao Sun, James C. Schnable, Harkamal Walia, Weibo Xie, Bin Yu, Jeffrey P. Mower & Chi Zhang. (2022) Pervasive misannotation of microexons that are evolutionarily conserved and crucial for gene function in plants. Nature Communications 13:1.
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Guido Hermey, Nils Blüthgen & Dietmar Kuhl. (2017) Neuronal activity-regulated alternative mRNA splicing. The International Journal of Biochemistry & Cell Biology 91, pages 184-193.
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Dmytro Ustianenko, Sebastien M. Weyn-Vanhentenryck & Chaolin Zhang. (2017) Microexons: discovery, regulation, and function. Wiley Interdisciplinary Reviews: RNA 8:4, pages e1418.
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Yang I. Li, Luis Sanchez-Pulido, Wilfried Haerty & Chris P. Ponting. (2015) RBFOX and PTBP1 proteins regulate the alternative splicing of micro-exons in human brain transcripts. Genome Research 25:1, pages 1-13.
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Li Yang & Ling-Ling Chen. (2014) Microexons Go Big. Cell 159:7, pages 1488-1489.
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Jie Wu, Olga Anczuków, Adrian R. Krainer, Michael Q. Zhang & Chaolin Zhang. (2013) OLego: fast and sensitive mapping of spliced mRNA-Seq reads using small seeds. Nucleic Acids Research 41:10, pages 5149-5163.
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Jitra Kriangkum, Amanda Warkinton, Andrew R. Belch & Linda M. Pilarski. (2013) Alteration of Introns in a Hyaluronan Synthase 1 (HAS1) Minigene Convert Pre-Mrna Splicing to the Aberrant Pattern in Multiple Myeloma (MM): MM Patients Harbor Similar Changes. PLoS ONE 8:1, pages e53469.
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Tzu-Ying Liu, Chih-Ying Chen, Chi-Chang Juan & Lo-Chun Au. (2013) Coding region of adiponectin contains a silent intron reactivated by the adjacent intervening sequence of vector. Plasmid 69:1, pages 67-71.
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Noriko Sasaki-Haraguchi, Makoto K. Shimada, Ichiro Taniguchi, Mutsuhito Ohno & Akila Mayeda. (2012) Mechanistic insights into human pre-mRNA splicing of human ultra-short introns: Potential unusual mechanism identifies G-rich introns. Biochemical and Biophysical Research Communications 423:2, pages 289-294.
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Erming Wang, William F. Mueller, Klemens J. Hertel & Franca Cambi. (2011) G Run-mediated Recognition of Proteolipid Protein and DM20 5′ Splice Sites by U1 Small Nuclear RNA Is Regulated by Context and Proximity to the Splice Site. Journal of Biological Chemistry 286:6, pages 4059-4071.
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Erming Wang & Franca Cambi. (2009) Heterogeneous Nuclear Ribonucleoproteins H and F Regulate the Proteolipid Protein/DM20 Ratio by Recruiting U1 Small Nuclear Ribonucleoprotein through a Complex Array of G Runs. Journal of Biological Chemistry 284:17, pages 11194-11204.
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Rune Frank-Hansen, Stephen P Page, Petros Syrris, William J McKenna, Michael Christiansen & Paal Skytt Andersen. (2008) Micro-exons of the cardiac myosin binding protein C gene: flanking introns contain a disproportionately large number of hypertrophic cardiomyopathy mutations. European Journal of Human Genetics 16:9, pages 1062-1069.
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Veiko Krauss, Christian Thümmler, Franziska Georgi, Jörg Lehmann, Peter F. Stadler & Carina Eisenhardt. (2008) Near Intron Positions Are Reliable Phylogenetic Markers: An Application to Holometabolous Insects. Molecular Biology and Evolution 25:5, pages 821-830.
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Chaolin Zhang, Michelle L. Hastings, Adrian R. Krainer & Michael Q. Zhang. (2007) Dual-specificity splice sites function alternatively as 5′ and 3′ splice sites. Proceedings of the National Academy of Sciences 104:38, pages 15028-15033.
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Julian P. Venables. (2007) Downstream intronic splicing enhancers. FEBS Letters 581:22, pages 4127-4131.
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Jane Y. Wu, Liya Yuan & Necat Havlioglu. 2006. Encyclopedia of Molecular Cell Biology and Molecular Medicine. Encyclopedia of Molecular Cell Biology and Molecular Medicine.
François Casas, Muriel Busson, Stéphanie Grandemange, Pascal Seyer, Angel Carazo, Laurence Pessemesse, Chantal Wrutniak-Cabello & Gérard Cabello. (2006) Characterization of a Novel Thyroid Hormone Receptor α Variant Involved in the Regulation of Myoblast Differentiation. Molecular Endocrinology 20:4, pages 749-763.
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Jana Královic̆ová & Igor Vor̆echovský. (2006) Position-Dependent Repression and Promotion of DQB1 Intron 3 Splicing by GGGG Motifs . The Journal of Immunology 176:4, pages 2381-2388.
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Rebeca Martinez-Contreras, Jean-François Fisette, Faiz-ul Hassan Nasim, Richard Madden, Mélanie Cordeau & Benoit Chabot. (2006) Intronic Binding Sites for hnRNP A/B and hnRNP F/H Proteins Stimulate Pre-mRNA Splicing. PLoS Biology 4:2, pages e21.
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David B. Carlini & Jordan E. Genut. (2005) Synonymous SNPs Provide Evidence for Selective Constraint on Human Exonic Splicing Enhancers. Journal of Molecular Evolution 62:1, pages 89-98.
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Daehyun Baek & Phil Green. (2005) Sequence conservation, relative isoform frequencies, and nonsense-mediated decay in evolutionarily conserved alternative splicing. Proceedings of the National Academy of Sciences 102:36, pages 12813-12818.
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T. D. Wu & C. K. Watanabe. (2005) GMAP: a genomic mapping and alignment program for mRNA and EST sequences. Bioinformatics 21:9, pages 1859-1875.
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Kyoungha Han, Gene Yeo, Ping An, Christopher B Burge & Paula J Grabowski. (2005) A Combinatorial Code for Splicing Silencing: UAGG and GGGG Motifs. PLoS Biology 3:5, pages e158.
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Veiko Krauss, Marek Pecyna, Katrin Kurz & Heinz Sass. (2005) Phylogenetic Mapping of Intron Positions: A Case Study of Translation Initiation Factor eIF2γ. Molecular Biology and Evolution 22:1, pages 74-84.
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Alain Expert-Bezançon, Alain Sureau, Patrice Durosay, Roland Salesse, Herman Groeneveld, Jean Pierre Lecaer & Joëlle Marie. (2004) hnRNP A1 and the SR Proteins ASF/SF2 and SC35 Have Antagonistic Functions in Splicing of β-Tropomyosin Exon 6B. Journal of Biological Chemistry 279:37, pages 38249-38259.
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Keith A. Friedman & Adam Heller. (2004) Guanosine Distribution and Oxidation Resistance in Eight Eukaryotic Genomes. Journal of the American Chemical Society 126:8, pages 2368-2371.
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Dieter Kaufmann, Oliver Kenner, Peter Nurnberg, Walther Vogel & Britta Bartelt. (2003) In NF1, CFTR, PER3, CARS and SYT7, alternatively included exons show higher conservation of surrounding intron sequences than constitutive exons. European Journal of Human Genetics 12:2, pages 139-149.
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KENNETH JAMES HOWE, CAROLINE M. KANE & MANUEL ARESJR.JR.. (2003) Perturbation of transcription elongation influences the fidelity of internal exon inclusion in Saccharomyces cerevisiae . RNA 9:8, pages 993-1006.
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Nathalie Heuzé-Vourc'h, Valérie Leblond & Yves Courty. (2003) Complex alternative splicing of the hKLK3 gene coding for the tumor marker PSA (prostate-specific-antigen). European Journal of Biochemistry 270:4, pages 706-714.
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Grace M. Hobson, Zhong Huang, Karen Sperle, Deborah L. Stabley, Harold G. Marks & Franca Cambi. (2002) A PLP splicing abnormality is associated with an unusual presentation of PMD. Annals of Neurology 52:4, pages 477-488.
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Alain Expert-Bezançon, Jean Pierre Le Caer & Joëlle Marie. (2002) Heterogeneous Nuclear Ribonucleoprotein (hnRNP) K Is a Component of an Intronic Splicing Enhancer Complex That Activates the Splicing of the Alternative Exon 6A from Chicken β-Tropomyosin Pre-mRNA. Journal of Biological Chemistry 277:19, pages 16614-16623.
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Zhi-An Yuan, Enhong Chen & Carolyn W. Gibson. (2001) Model System for Evaluation of Alternative Splicing: Exon Skipping. DNA and Cell Biology 20:12, pages 807-813.
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Thomas Genetta, Hiroko Morisaki, Takayuki Morisaki & Edward W. Holmes. (2001) A Novel Bipartite Intronic Splicing Enhancer Promotes the Inclusion of a Mini-exon in the AMP Deaminase 1 Gene. Journal of Biological Chemistry 276:27, pages 25589-25597.
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Stephen M. Mount. (2000) Genomic Sequence, Splicing, and Gene Annotation. The American Journal of Human Genetics 67:4, pages 788-792.
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