14
Views
77
CrossRef citations to date
0
Altmetric
DNA Dynamics and Chromosome Structure

Homologous and Nonhomologous Recombination Resulting in Deletion: Effects of p53 Status, Microhomology, and Repetitive DNA Length and Orientation

, &
Pages 4028-4035 | Received 29 Jun 1999, Accepted 24 Jan 2000, Published online: 28 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Travis B White, Maria E Morales & Prescott L Deininger. (2015) Alu elements and DNA double-strand break repair. Mobile Genetic Elements 5:6, pages 81-85.
Read now
Stephen T. Durant, Kimberly S. Paffett, Meena Shrivastav, Graham S. Timmins, William F. Morgan & Jac A. Nickoloff. (2006) UV Radiation Induces Delayed Hyperrecombination Associated with Hypermutation in Human Cells. Molecular and Cellular Biology 26:16, pages 6047-6055.
Read now
A. Böhnke, F. Westphal, A. Schmidt, R. A. El‐Awady & J. Dahm‐Daphi. (2004) Role of p53 mutations, protein function and DNA damage for the radiosensitivity of human tumour cells. International Journal of Radiation Biology 80:1, pages 53-63.
Read now
Nuray Akyüz, Gisa S. Boehden, Silke Süsse, Andreas Rimek, Ute Preuss, Karl-Heinz Scheidtmann & Lisa Wiesmüller. (2002) DNA Substrate Dependence of p53-Mediated Regulation of Double-Strand Break Repair. Molecular and Cellular Biology 22:17, pages 6306-6317.
Read now
Anthony W. I. Lo, Carl N. Sprung, Bijan Fouladi, Mehrdad Pedram, Laure Sabatier, Michelle Ricoul, Gloria E. Reynolds & John P. Murnane. (2002) Chromosome Instability as a Result of Double-Strand Breaks near Telomeres in Mouse Embryonic Stem Cells. Molecular and Cellular Biology 22:13, pages 4836-4850.
Read now

Articles from other publishers (72)

Mark A. Miles & Christine J. Hawkins. (2018) Mutagenic assessment of chemotherapy and Smac mimetic drugs in cells with defective DNA damage response pathways. Scientific Reports 8:1.
Crossref
Sheng-Yong Yang, Yi Li, Guo-Shun An, Ju-Hua Ni, Hong-Ti Jia & Shu-Yan Li. (2018) DNA Damage-Response Pathway Heterogeneity of Human Lung Cancer A549 and H1299 Cells Determines Sensitivity to 8-Chloro-Adenosine. International Journal of Molecular Sciences 19:6, pages 1587.
Crossref
Reuben M. Buckley, R. Daniel Kortschak & David L. Adelson. (2018) Divergent genome evolution caused by regional variation in DNA gain and loss between human and mouse. PLOS Computational Biology 14:4, pages e1006091.
Crossref
Tiffany K Kaul, Maria E Morales & Prescott L Deininger. 2001. eLS. eLS 1 8 .
Maria E. Morales, Geraldine Servant, Catherine M. Ade & Prescott Deininger. 2017. Human Retrotransposons in Health and Disease. Human Retrotransposons in Health and Disease 239 257 .
Sridaran Dhivya & Kumpati Premkumar. (2016) Nomadic genetic elements contribute to oncogenic translocations: Implications in carcinogenesis. Critical Reviews in Oncology/Hematology 98, pages 81-93.
Crossref
Maria E. Morales, Travis B. White, Vincent A. Streva, Cecily B. DeFreece, Dale J. Hedges & Prescott L. Deininger. (2015) The Contribution of Alu Elements to Mutagenic DNA Double-Strand Break Repair. PLOS Genetics 11:3, pages e1005016.
Crossref
Lukrecija Brečević, Martina Rinčić, Željka Krsnik, Goran Sedmak, Ahmed B. Hamid, Nadezda Kosyakova, Ivan Galić, Thomas Liehr & Fran Borovečki. (2015) Association of new deletion/duplication region at chromosome 1p21 with intellectual disability, severe speech deficit and autism spectrum disorder-like behavior: an all-in approach to solving the DPYD enigma. Translational Neuroscience 6:1, pages 59-86.
Crossref
M. E. Chrissie Rey, Johan Harmse, Sarah H. Taylor, Patrick Arbuthnot & Marc S. Weinberg. 2015. Plant Gene Silencing. Plant Gene Silencing 295 304 .
Kayvan Zainabadi, Anuja V. Jain, Frank X. Donovan, David Elashoff, Nagesh P. Rao, Vundavalli V. Murty, Settara C. Chandrasekharappa & Eri S. Srivatsan. (2014) One in four individuals of African-American ancestry harbors a 5.5 kb deletion at chromosome 11q13.1. Genomics 103:4, pages 276-287.
Crossref
Sean P. PitrodaItai M. PashtanHillary L. LoganBrian BudkeThomas E. DargaRalph R. WeichselbaumPhilip P. Connell. (2014) DNA Repair Pathway Gene Expression Score Correlates with Repair Proficiency and Tumor Sensitivity to Chemotherapy. Science Translational Medicine 6:229.
Crossref
Mariem Ben Rekaya, Nadia Laroussi, Olfa Messaoud, Mariem Jones, Manel Jerbi, Chokri Naouali, Yosra Bouyacoub, Mariem Chargui, Rym Kefi, Becima Fazaa, Mohamed Samir Boubaker, Hamouda Boussen, Mourad Mokni, Sonia Abdelhak, Mohamed Zghal, Aida Khaled & Houda Yacoub-Youssef. (2014) A Founder Large Deletion Mutation in Xeroderma Pigmentosum-Variant Form in Tunisia: Implication for Molecular Diagnosis and Therapy. BioMed Research International 2014, pages 1-8.
Crossref
Catherine Ade, Astrid M Roy-Engel & Prescott L Deininger. (2013) Alu elements: an intrinsic source of human genome instability. Current Opinion in Virology 3:6, pages 639-645.
Crossref
Andrew M. Cobb, Brian R. Jackson, Ella Kim, Philip L. Bond & Richard P. Bowater. (2013) Sequence-specific and DNA structure-dependent interactions of Escherichia coli MutS and human p53 with DNA. Analytical Biochemistry 442:1, pages 51-61.
Crossref
Daisuke Hibi, Aki Kijima, Yuta Suzuki, Yuji Ishii, Meilan Jin, Yoshiko Sugita-Konishi, Tokuma Yanai, Akiyoshi Nishikawa & Takashi Umemura. (2013) Effects of p53 knockout on ochratoxin A-induced genotoxicity in p53-deficient gpt delta mice. Toxicology 304, pages 92-99.
Crossref
Daisuke Hibi, Aki Kijima, Ken Kuroda, Yuta Suzuki, Yuji Ishii, Meilan Jin, Masahiro Nakajima, Yoshiko Sugita-Konishi, Tokuma Yanai, Takehiko Nohmi, Akiyoshi Nishikawa & Takashi Umemura. (2013) Molecular mechanisms underlying ochratoxin A-induced genotoxicity: global gene expression analysis suggests induction of DNA double-strand breaks and cell cycle progression. The Journal of Toxicological Sciences 38:1, pages 57-69.
Crossref
Mineo Senda, Satsuki Nishimura, Atsushi Kasai, Setsuzo Yumoto, Yoshitake Takada, Yoshinori Tanaka, Shizen Ohnishi & Tomohisa Kuroda. (2013) Comparative analysis of the inverted repeat of a chalcone synthase pseudogene between yellow soybean and seed coat pigmented mutants. Breeding Science 63:4, pages 384-392.
Crossref
Sarah H. Taylor, Johan Harmse, Patrick Arbuthnot, Fiona Van Den Berg, Marco S. Weinberg & Marie E.C. Rey. (2012) Construction of effective inverted repeat silencing constructs using sodium bisulfite treatment coupled with strand-specific PCR. BioTechniques 52:4, pages 254-262.
Crossref
Pelin Akan, Andrey Alexeyenko, Paul Costea, Lilia Hedberg, Beata Solnestam, Sverker Lundin, Jimmie Hällman, Emma Lundberg, Mathias Uhlén & Joakim Lundeberg. (2012) Comprehensive analysis of the genome transcriptome and proteome landscapes of three tumor cell lines. Genome Medicine 4:11, pages 86.
Crossref
Astrid M Roy‐Engel & Victoria P Belancio. 2001. eLS. eLS.
Radan Goldmann, Lukáš Tichý, Tomáš Freiberger, Petra Zapletalová, Ondřej Letocha, Vladimír Soška, Jiří Fajkus & Lenka Fajkusová. (2010) Genomic characterization of large rearrangements of the LDLR gene in Czech patients with familial hypercholesterolemia. BMC Medical Genetics 11:1.
Crossref
Victoria P. Belancio, Astrid M. Roy-Engel & Prescott L. Deininger. (2010) All y’all need to know ‘bout retroelements in cancer. Seminars in Cancer Biology 20:4, pages 200-210.
Crossref
Syed Khizer Hasan, Tiziana Ottone, Richard F. Schlenk, Yuanyuan Xiao, Joseph L. Wiemels, Maria Enza Mitra, Paolo Bernasconi, Francesco Di Raimondo, Maria Teresa Lupo Stanghellini, Pepa Marco, Ashley N. Mays, Hartmut Döhner, Miguel A. Sanz, Sergio Amadori, David Grimwade & Francesco Lo-Coco. (2010) Analysis of t(15;17) chromosomal breakpoint sequences in therapy-related versus de novo acute promyelocytic leukemia: Association of DNA breaks with specific DNA motifs at PML and RARA loci. Genes, Chromosomes and Cancer 49:8, pages 726-732.
Crossref
Sridharan Rajagopalan, Antonina Andreeva, Trevor J. Rutherford & Alan R. Fersht. (2010) Mapping the physical and functional interactions between the tumor suppressors p53 and BRCA2. Proceedings of the National Academy of Sciences 107:19, pages 8587-8592.
Crossref
Jae-Won Huh, Young-Hyun Kim, Sang-Rae Lee, Dae-Soo Kim, Sang-Je Park, Hyoungwoo Kim, Ji-Su Kim, Bong-Seok Song, Heui-Soo Kim & Kyu-Tae Chang. (2010) Four different ways of alternative transcripts generation mechanism in ADRA1A gene. Genes & Genetic Systems 85:1, pages 65-73.
Crossref
Jungnam Lee, Kyudong Han, Thomas J. Meyer, Heui-Soo Kim & Mark A. Batzer. (2008) Chromosomal Inversions between Human and Chimpanzee Lineages Caused by Retrotransposons. PLoS ONE 3:12, pages e4047.
Crossref
Kyudong Han, Jungnam Lee, Thomas J. Meyer, Paul Remedios, Lindsey Goodwin & Mark A. Batzer. (2008) L1 recombination-associated deletions generate human genomic variation. Proceedings of the National Academy of Sciences 105:49, pages 19366-19371.
Crossref
Marlen Keimling, Jatinder Kaur, Sarangadhara Appala Raju Bagadi, Rolf Kreienberg, Lisa Wiesmüller & Ranju Ralhan. (2008) A sensitive test for the detection of specific DSB repair defects in primary cells from breast cancer specimens. International Journal of Cancer 123:3, pages 730-736.
Crossref
Dale J Hedges & Prescott L Deininger. 2001. eLS. eLS.
Prescott L. Deininger & Astrid M. Roy‐Engel. 2007. Mobile DNA II. Mobile DNA II 1074 1092 .
Wanjun Gu, David A. Ray, Jerilyn A. Walker, Erin W. Barnes, Andrew J. Gentles, Paul B. Samollow, Jerzy Jurka, Mark A. Batzer & David D. Pollock. (2007) SINEs, evolution and genome structure in the opossum. Gene 396:1, pages 46-58.
Crossref
Tamim H. Shaikh, Ronald J. O’Connor, Mary Ella Pierpont, James McGrath, April M. Hacker, Manjunath Nimmakayalu, Elizabeth Geiger, Beverly S. Emanuel & Sulagna C. Saitta. (2007) Low copy repeats mediate distal chromosome 22q11.2 deletions: Sequence analysis predicts breakpoint mechanisms. Genome Research 17:4, pages 482-491.
Crossref
D.J. Hedges & P.L. Deininger. (2007) Inviting instability: Transposable elements, double-strand breaks, and the maintenance of genome integrity. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 616:1-2, pages 46-59.
Crossref
David A. Ray, Jerilyn A. Walker & Mark A. Batzer. (2007) Mobile element-based forensic genomics. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 616:1-2, pages 24-33.
Crossref
DAVID A. RAY. (2006) SINEs of progress: Mobile element applications to molecular ecology. Molecular Ecology 16:1, pages 19-33.
Crossref
Ramune Reliene, Alexander J.R. Bishop & Robert H. Schiestl. 2007. 67 87 .
John P. Murnane. 2007. Apoptosis, Senescence, and Cancer. Apoptosis, Senescence, and Cancer 173 189 .
Susanne Andrea Gatz & Lisa Wiesmüller. 2007. Genome Integrity. Genome Integrity 243 266 .
John P. Murnane. (2006) Telomeres and chromosome instability. DNA Repair 5:9-10, pages 1082-1092.
Crossref
S A Gatz & L Wiesmüller. (2006) p53 in recombination and repair. Cell Death & Differentiation 13:6, pages 1003-1016.
Crossref
Susan McVety, Lili Li, Isabelle Thiffault, Philip H. Gordon, Elizabeth MacNamara, Nora Wong, Karlene Australie, Lidia Kasprzak, George Chong & William D Foulkes. (2006) The Value of Multi-Modal Gene Screening in HNPCC in Quebec: Three Mutations in Mismatch Repair Genes that would have not been Correctly Identified by Genomic DNA Sequencing Alone. Familial Cancer 5:1, pages 21-28.
Crossref
Mohammed El‐Sawy & Prescott Deininger. 2001. eLS. eLS.
Prescott Deininger. 2006. Genomic Disorders. Genomic Disorders 21 34 .
David A. Ray, Dale J. Hedges, Scott W. Herke, Justin D. Fowlkes, Erin W. Barnes, Daniel K. LaVie, Lindsey M. Goodwin, Llewellyn D. Densmore & Mark A. Batzer. (2005) Chompy: An infestation of MITE-like repetitive elements in the crocodilian genome. Gene 362, pages 1-10.
Crossref
S McVety, R Younan, L Li, PH Gordon, N Wong, WD Foulkes & G Chong. (2005) Novel genomic insertion-deletion in MLH1: possible mechanistic role for non-homologous end-joining DNA repair. Clinical Genetics 68:3, pages 234-238.
Crossref
Deepak Grover, K. Kannan, Samir K. Brahmachari & Mitali Mukerji. (2005) ALU-ring elements in the primate genomes. Genetica 124:2-3, pages 273-289.
Crossref
Gisa S Boehden, Cindy Baumann, Simone Siehler & Lisa Wiesmüller. (2005) Wild-type p53 stimulates homologous recombination upon sequence-specific binding to the ribosomal gene cluster repeat. Oncogene 24:26, pages 4183-4192.
Crossref
Kayvan Zainabadi, Payam Benyamini, Rita Chakrabarti, Mysore S. Veena, Settara C. Chandrasekharappa, Richard A. Gatti & Eri S. Srivatsan. (2005) A 700-kb physical and transcription map of the cervical cancer tumor suppressor gene locus on chromosome 11q13. Genomics 85:6, pages 704-714.
Crossref
Yannick Saintigny, Pascale Bertrand & Bernard S. Lopez. (2005) Rôle direct de p53 dans la recombinaison homologue . médecine/sciences 21:1, pages 43-48.
Crossref
Masamitsu Honma. (2005) Generation of loss of heterozygosity and its dependency on p53 status in human lymphoblastoid cells. Environmental and Molecular Mutagenesis 45:2-3, pages 162-176.
Crossref
Larisa Y Romanova, Henning Willers, Mikhail V Blagosklonny & Simon N Powell. (2004) The interaction of p53 with replication protein A mediates suppression of homologous recombination. Oncogene 23:56, pages 9025-9033.
Crossref
John P. Murnane & Laure Sabatier. (2004) Chromosome rearrangements resulting from telomere dysfunction and their role in cancer. BioEssays 26:11, pages 1164-1174.
Crossref
Carrie A. Hendricks & Bevin P. Engelward. (2004) “Recombomice”: The past, present, and future of recombination–detection in mice. DNA Repair 3:10, pages 1255-1261.
Crossref
Josée Guirouilh-Barbat, Sylvie Huck, Pascale Bertrand, Livia Pirzio, Chantal Desmaze, Laure Sabatier & Bernard S. Lopez. (2004) Impact of the KU80 Pathway on NHEJ-Induced Genome Rearrangements in Mammalian Cells. Molecular Cell 14:5, pages 611-623.
Crossref
Qin Yang, Ran Zhang, Xin W Wang, Steven P Linke, Sagar Sengupta, Ian D Hickson, Graziella Pedrazzi, Claudia Perrera, Igor Stagljar, Susan J Littman, Paul Modrich & Curtis C Harris. (2004) The mismatch DNA repair heterodimer, hMSH2/6, regulates BLM helicase. Oncogene 23:21, pages 3749-3756.
Crossref
Prescott L Deininger, John V Moran, Mark A Batzer & Haig H KazazianJrJr. (2003) Mobile elements and mammalian genome evolution. Current Opinion in Genetics & Development 13:6, pages 651-658.
Crossref
Michael Overholtzer, Pulivarthi H. Rao, Reyna Favis, Xin-Yan Lu, Michael B. Elowitz, Francis Barany, Marc Ladanyi, Richard Gorlick & Arnold J. Levine. (2003) The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability. Proceedings of the National Academy of Sciences 100:20, pages 11547-11552.
Crossref
Kristoffer Valerie & Lawrence F Povirk. (2003) Regulation and mechanisms of mammalian double-strand break repair. Oncogene 22:37, pages 5792-5812.
Crossref
Carrie A. Hendricks, Karen H. Almeida, Molly S. Stitt, Vidya S. Jonnalagadda, Rebecca E. Rugo, G. Foster Kerrison & Bevin P. Engelward. (2003) Spontaneous mitotic homologous recombination at an enhanced yellow fluorescent protein (EYFP) cDNA direct repeat in transgenic mice. Proceedings of the National Academy of Sciences 100:11, pages 6325-6330.
Crossref
Alexander J.R Bishop & Robert H Schiestl. (2003) Role of homologous recombination in carcinogenesis. Experimental and Molecular Pathology 74:2, pages 94-105.
Crossref
K. Fleming, D.K. Riser, D. Kumari & K. Usdin. (2003) Instability of the fragile X syndrome repeat in mice: the effect of age, diet and mutations in genes that affect DNA replication, recombination and repair proficiency. Cytogenetic and Genome Research 100:1-4, pages 140-146.
Crossref
Xiongbin Lu, Guillermina Lozano & Lawrence A. Donehower. (2003) Activities of wildtype and mutant p53 in suppression of homologous recombination as measured by a retroviral vector system. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 522:1-2, pages 69-83.
Crossref
Tomasz Skorski. (2002) BCR/ABL regulates response to DNA damage: the role in resistance to genotoxic treatment and in genomic instability. Oncogene 21:56, pages 8591-8604.
Crossref
Ana I Robles, Steven P Linke & Curtis C Harris. (2002) The p53 network in lung carcinogenesis. Oncogene 21:45, pages 6898-6907.
Crossref
Prescott L. Deininger & Mark A. Batzer. (2002) Mammalian Retroelements. Genome Research 12:10, pages 1455-1465.
Crossref
Daniele Zink, Christoph Mayr, Christine Janz & Lisa Wiesmüller. (2002) Association of p53 and MSH2 with recombinative repair complexes during S phase. Oncogene 21:31, pages 4788-4800.
Crossref
Mark A. Batzer & Prescott L. Deininger. (2002) Alu repeats and human genomic diversity. Nature Reviews Genetics 3:5, pages 370-379.
Crossref
Tomasz Skorski. (2002) Oncogenic tyrosine kinases and the dna-damage response. Nature Reviews Cancer 2:5, pages 351-360.
Crossref
Christine Janz, Silke Süsse & Lisa Wiesmüller. (2002) p53 and recombination intermediates: role of tetramerization at DNA junctions in complex formation and exonucleolytic degradation. Oncogene 21:14, pages 2130-2140.
Crossref
Karen M. Vasquez, Kathleen Marburger, Zsofia Intody & John H. Wilson. (2001) Manipulating the mammalian genome by homologous recombination. Proceedings of the National Academy of Sciences 98:15, pages 8403-8410.
Crossref
Alexander J.R Bishop & Robert H Schiestl. (2001) Homologous recombination as a mechanism of carcinogenesis. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1471:3, pages M109-M121.
Crossref
Judith E. Stenger, Kirill S. Lobachev, Dmitry Gordenin, Thomas A. Darden, Jerzy Jurka & Michael A. Resnick. (2001) Biased Distribution of Inverted and Direct Alu s in the Human Genome: Implications for Insertion, Exclusion, and Genome Stability . Genome Research 11:1, pages 12-27.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.