Advanced search
Publication Cover
Molecular and Cellular Biology Volume 20, 2000 - Issue 11
Submit an article Journal homepage
34
Views
86
CrossRef citations to date
0
Altmetric
Mammalian Genetic Models with Minimal or Complex Phenotypes

Altered Activity, Social Behavior, and Spatial Memory in Mice Lacking the NTAN1p Amidase and the Asparagine Branch of the N-End Rule Pathway

Yong Tae Kwon1 Division of Biology, California Institute of Technology, Pasadena, California91125
,
Seth A. Balogh2 Biobehavioral Sciences Graduate Program
,
Ilia V. Davydov1 Division of Biology, California Institute of Technology, Pasadena, California91125
,
Anna S. Kashina1 Division of Biology, California Institute of Technology, Pasadena, California91125
,
Jeong Kyo Yoon1 Division of Biology, California Institute of Technology, Pasadena, California91125
,
Youming Xie1 Division of Biology, California Institute of Technology, Pasadena, California91125
,
Arti Gaur1 Division of Biology, California Institute of Technology, Pasadena, California91125
,
Lynn Hyde2 Biobehavioral Sciences Graduate Program
,
Victor H. Denenberg2 Biobehavioral Sciences Graduate Program;3 Department of Psychology, University of Connecticut, Storrs, Connecticut06269-4154
&
Alexander Varshavsky1 Division of Biology, California Institute of Technology, Pasadena, California91125Correspondence[email protected]
 show all
Pages 4135-4148 | Received 30 Dec 1999, Accepted 08 Mar 2000, Published online: 28 Mar 2023

Citations (86)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (3)

Takafumi Tasaki, Lubbertus C. F. Mulder, Akihiro Iwamatsu, Min Jae Lee, Ilia V. Davydov, Alexander Varshavsky, Mark Muesing & Yong Tae Kwon. (2005) A Family of Mammalian E3 Ubiquitin Ligases That Contain the UBR Box Motif and Recognize N-Degrons. Molecular and Cellular Biology 25:16, pages 7120-7136.
Read now
Yong Tae Kwon, Zanxian Xia, Jee Young An, Takafumi Tasaki, Ilia V. Davydov, Jai Wha Seo, Jun Sheng, Youming Xie & Alexander Varshavsky. (2003) Female Lethality and Apoptosis of Spermatocytes in Mice Lacking the UBR2 Ubiquitin Ligase of the N-End Rule Pathway. Molecular and Cellular Biology 23:22, pages 8255-8271.
Read now
Yong Tae Kwon, Zanxian Xia, Ilia V. Davydov, Stewart H. Lecker & Alexander Varshavsky. (2001) Construction and Analysis of Mouse Strains Lacking the Ubiquitin Ligase UBR1 (E3α) of the N-End Rule Pathway. Molecular and Cellular Biology 21:23, pages 8007-8021.
Read now

Articles from other publishers (83)

Ah Jung Heo, Su Bin Kim, Yong Tae Kwon & Chang Hoon Ji. (2023) The N-degron pathway: From basic science to therapeutic applications. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1866:2, pages 194934.
Crossref
Ah Jung Heo, Chang Hoon Ji & Yong Tae Kwon. (2023) The Cys/N-degron pathway in the ubiquitin–proteasome system and autophagy. Trends in Cell Biology 33:3, pages 247-259.
Crossref
Su Jin Lee, Hye Yeon Kim, Min Ju Lee, Su Bin Kim, Yong Tae Kwon & Chang Hoon Ji. 2023. Modifications and targeting of protein termini: Part B. Modifications and targeting of protein termini: Part B 235 265 .
Elizabeth D. Buttermore, Nickesha C. Anderson, Pin-Fang Chen, Nina R. Makhortova, Kristina H. Kim, Syed M. A. Wafa, Sean Dwyer, John M. Micozzi, Kellen D. Winden, Bo Zhang, Min-Joon Han, Robin J. Kleiman, Catherine A. Brownstein, Mustafa Sahin & Joseph Gonzalez-Heydrich. (2022) 16p13.11 deletion variants associated with neuropsychiatric disorders cause morphological and synaptic changes in induced pluripotent stem cell-derived neurons. Frontiers in Psychiatry 13.
Crossref
Ana Castañeda-Sampedro, Laura Calvin-Cejudo, Fernando Martin, Carolina Gomez-Diaz & Esther Alcorta. (2022) The Ntan1 gene is expressed in perineural glia and neurons of adult Drosophila. Scientific Reports 12:1.
Crossref
Bong Heon Kim, Min Kyung Kim, Sun Joo Oh, Kha The Nguyen, Jun Hoe Kim, Alexander Varshavsky, Cheol-Sang Hwang & Hyun Kyu Song. (2022) Crystal structure of the Ate1 arginyl-tRNA-protein transferase and arginylation of N-degron substrates. Proceedings of the National Academy of Sciences 119:31.
Crossref
Jung Gi Kim, Ho-Chul Shin, Taewook Seo, Laxman Nawale, Goeun Han, Bo Yeon Kim, Seung Jun Kim & Hyunjoo Cha-Molstad. (2021) Signaling Pathways Regulated by UBR Box-Containing E3 Ligases. International Journal of Molecular Sciences 22:15, pages 8323.
Crossref
Guangdong Zhao, Chen Wang, Ying Wang, Lijun Wang, Baohua Xu & Xingqi Guo. (2020) Role of Apis cerana cerana N-terminal asparagine amidohydrolase (AccNtan1) in oxidative stress. The Journal of Biochemistry 168:4, pages 337-348.
Crossref
Tri T. M. Vu & Alexander Varshavsky. (2020) The ATF3 Transcription Factor Is a Short-Lived Substrate of the Arg/N-Degron Pathway. Biochemistry 59:30, pages 2796-2812.
Crossref
Jang-Hyun Oh, Ju-Yeon Hyun, Shun-Jia Chen & Alexander Varshavsky. (2020) Five enzymes of the Arg/N-degron pathway form a targeting complex: The concept of superchanneling. Proceedings of the National Academy of Sciences 117:20, pages 10778-10788.
Crossref
Joon Sung Park, Jae-Young Lee, Yen Thi Kim Nguyen, Nae-Won Kang, Eun Kyung Oh, Dong Man Jang, Hyun-Jung Kim, Dae-Duk Kim & Byung Woo Han. (2020) Structural Analyses on the Deamidation of N-Terminal Asn in the Human N-Degron Pathway. Biomolecules 10:1, pages 163.
Crossref
Xavier Gallart-Palau, Le Min Tan, Aida Serra, Yonggui Gao, Hee Hwa Ho, A. Mark Richards, Nagaendran Kandiah, Christopher P. Chen, Raj N. Kalaria & Siu Kwan Sze. (2019) Degenerative protein modifications in the aging vasculature and central nervous system: A problem shared is not always halved. Ageing Research Reviews 53, pages 100909.
Crossref
Nico Dissmeyer. (2019) Conditional Protein Function via N-Degron Pathway–Mediated Proteostasis in Stress Physiology. Annual Review of Plant Biology 70:1, pages 83-117.
Crossref
Young-Sun Lee & Yong J. Lee. 2019. Ferroptosis in Health and Disease. Ferroptosis in Health and Disease 83 98 .
Sang Mi Shim, Ha Rim ChoiKi Woon Sung, Yoon Jee Lee, Sung Tae Kim, Daeho KimSu Ran Mun, Joonsung HwangHyunjoo Cha-Molstad, Aaron Ciechanover, Bo Yeon Kim & Yong Tae Kwon. (2018) The endoplasmic reticulum–residing chaperone BiP is short-lived and metabolized through N-terminal arginylation. Science Signaling 11:511.
Crossref
Sung Tae Kim, Yoon Jee Lee, Takafumi Tasaki, Suran Mun, Joonsung Hwang, Min Jueng Kang, Srinivasrao Ganipisetti, Eugene C. Yi, Bo Yeon Kim & Yong Tae Kwon. (2018) The N-recognin UBR4 of the N-end rule pathway is targeted to and required for the biogenesis of the early endosome. Journal of Cell Science.
Crossref
Aaron Ciechanover & Yong Tae Kwon. (2017) Protein Quality Control by Molecular Chaperones in Neurodegeneration. Frontiers in Neuroscience 11.
Crossref
Nicholas J. Bradshaw & Mirian A. F. Hayashi. (2016) NDE1 and NDEL1 from genes to (mal)functions: parallel but distinct roles impacting on neurodevelopmental disorders and psychiatric illness. Cellular and Molecular Life Sciences 74:7, pages 1191-1210.
Crossref
Yujiao Liu, Chao Liu, Wen Dong & Wei Li. (2016) Physiological functions and clinical implications of the N-end rule pathway. Frontiers of Medicine 10:3, pages 258-270.
Crossref
N.J. Bradshaw. (2016) Cloning of the promoter of NDE1, a gene implicated in psychiatric and neurodevelopmental disorders through copy number variation. Neuroscience 324, pages 262-270.
Crossref
Catherine A. Brownstein, Robin J. Kleiman, Elizabeth C. Engle, Meghan C. Towne, Eugene J. D'Angelo, Timothy W. Yu, Alan H. Beggs, Jonathan Picker, Jason M. Fogler, Devon Carroll, Rachel C. O. Schmitt, Robert R. Wolff, Yiping Shen, Va Lip, Kaya Bilguvar, April Kim, Sahil Tembulkar, Kyle O'Donnell & Joseph Gonzalez-Heydrich. (2016) Overlapping 16p13.11 deletion and gain of copies variations associated with childhood onset psychosis include genes with mechanistic implications for autism associated pathways: Two case reports. American Journal of Medical Genetics Part A 170:5, pages 1165-1173.
Crossref
Adam H. Freedman, Rena M. Schweizer, Diego Ortega-Del Vecchyo, Eunjung Han, Brian W. Davis, Ilan Gronau, Pedro M. Silva, Marco Galaverni, Zhenxin Fan, Peter Marx, Belen Lorente-Galdos, Oscar Ramirez, Farhad Hormozdiari, Can Alkan, Carles Vilà, Kevin Squire, Eli Geffen, Josip Kusak, Adam R. Boyko, Heidi G. Parker, Clarence Lee, Vasisht Tadigotla, Adam Siepel, Carlos D. Bustamante, Timothy T. Harkins, Stanley F. Nelson, Tomas Marques-Bonet, Elaine A. Ostrander, Robert K. Wayne & John Novembre. (2016) Demographically-Based Evaluation of Genomic Regions under Selection in Domestic Dogs. PLOS Genetics 12:3, pages e1005851.
Crossref
Alex V. Kotlar, Kristina B. Mercer, Michael E. Zwick & Jennifer G. Mulle. (2015) New discoveries in schizophrenia genetics reveal neurobiological pathways: A review of recent findings. European Journal of Medical Genetics 58:12, pages 704-714.
Crossref
A. Saskia Venne, Fiorella A. Solari, Frederik Faden, Tomasso Paretti, Nico Dissmeyer & René P. Zahedi. (2015) An improved workflow for quantitative N-terminal charge-based fractional diagonal chromatography (ChaFRADIC) to study proteolytic events in Arabidopsis thaliana . PROTEOMICS 15:14, pages 2458-2469.
Crossref
Elisa Tassano, Lucia De Santis, Maria Corona, Stefano Parmigiani, Dalila Zanetti, Simona Porta, Giorgio Gimelli & Cristina Cuoco. (2015) Concomitant deletion of chromosome 16p13.11 and triplication of chromosome 19p13.3 in a child with developmental disorders, intellectual disability, and epilepsy. Molecular Cytogenetics 8:1, pages 9.
Crossref
Xinkun Wang, Nilam D Patel, Dongwei Hui, Ranu Pal, Mohamed M Hafez, Mohamed M Sayed-Ahmed, Abdulaziz A Al-Yahya & Elias K Michaelis. (2014) Gene expression patterns in the hippocampus during the development and aging of Glud1(Glutamate Dehydrogenase 1) transgenic and wild type mice. BMC Neuroscience 15:1.
Crossref
Mi Seul Park, Eduard Bitto, Kyung Rok Kim, Craig A. Bingman, Mitchell D. Miller, Hyun-Jung Kim, Byung Woo Han & George N. Phillips. (2014) Crystal Structure of Human Protein N-Terminal Glutamine Amidohydrolase, an Initial Component of the N-End Rule Pathway. PLoS ONE 9:10, pages e111142.
Crossref
Maria Tropeano, Joris Andrieux & David A Collier. (2013) Clinical utility gene card for: 16p13.11 microdeletion syndrome. European Journal of Human Genetics 22:5, pages 713-713.
Crossref
Maria Tropeano, Joo Wook Ahn, Richard J. B. Dobson, Gerome Breen, James Rucker, Abhishek Dixit, Deb K. Pal, Peter McGuffin, Anne Farmer, Peter S. White, Joris Andrieux, Evangelos Vassos, Caroline Mackie Ogilvie, Sarah Curran & David A Collier. (2013) Male-Biased Autosomal Effect of 16p13.11 Copy Number Variation in Neurodevelopmental Disorders. PLoS ONE 8:4, pages e61365.
Crossref
Takafumi TasakiSung Tae KimAdriana ZakrzewskaBo Eun LeeMin Jueng KangYoung Dong YooHyun Joo Cha-MolstadJoonsung HwangNak Kyun SoungKi Sa SungSu-Hyeon KimMinh Dang Nguyen, Ming Sun, Eugene C. YiBo Yeon KimYong Tae Kwon. (2013) UBR box N-recognin-4 (UBR4), an N-recognin of the N-end rule pathway, and its role in yolk sac vascular development and autophagy. Proceedings of the National Academy of Sciences 110:10, pages 3800-3805.
Crossref
Alexander Varshavsky. (2012) Augmented generation of protein fragments during wakefulness as the molecular cause of sleep: a hypothesis. Protein Science 21:11, pages 1634-1661.
Crossref
Takafumi TasakiShashikanth M. SriramKyong Soo Park & Yong Tae Kwon. (2012) The N-End Rule Pathway. Annual Review of Biochemistry 81:1, pages 261-289.
Crossref
Kok Wei Lee, Puay San Woon, Yik Ying Teo & Kang Sim. (2012) Genome wide association studies (GWAS) and copy number variation (CNV) studies of the major psychoses: What have we learnt?. Neuroscience & Biobehavioral Reviews 36:1, pages 556-571.
Crossref
Kristen L. Deak, Sarah R. Horn & Catherine W. Rehder. (2011) The Evolving Picture of Microdeletion/Microduplication Syndromes in the Age of Microarray Analysis: Variable Expressivity and Genomic Complexity. Clinics in Laboratory Medicine 31:4, pages 543-564.
Crossref
Shashikanth M. Sriram, Bo Yeon Kim & Yong Tae Kwon. (2011) The N-end rule pathway: emerging functions and molecular principles of substrate recognition. Nature Reviews Molecular Cell Biology 12:11, pages 735-747.
Crossref
Alexander Varshavsky. (2011) The N-end rule pathway and regulation by proteolysis. Protein Science 20:8, pages 1298-1345.
Crossref
M. Balasubramanian, K. Smith, S.R. Mordekar & M.J. Parker. (2011) Clinical report: An interstitial deletion of 16p13.11 detected by array CGH in a patient with infantile spasms. European Journal of Medical Genetics 54:3, pages 314-318.
Crossref
Jason R. Cantor, Everett M. Stone & George Georgiou. (2011) Expression and Biochemical Characterization of the Human Enzyme N-Terminal Asparagine Amidohydrolase. Biochemistry 50:14, pages 3025-3033.
Crossref
Sandesh C Sreenath Nagamani, Ayelet Erez, Patricia Bader, Seema R Lalani, Daryl A Scott, Fernando Scaglia, Sharon E Plon, Chun-Hui Tsai, Tyler Reimschisel, Elizabeth Roeder, Amy D Malphrus, Patricia A Eng, Patricia M Hixson, Sung-Hae L Kang, Pawel Stankiewicz, Ankita Patel & Sau Wai Cheung. (2010) Phenotypic manifestations of copy number variation in chromosome 16p13.11. European Journal of Human Genetics 19:3, pages 280-286.
Crossref
A Ingason, D Rujescu, S Cichon, E Sigurdsson, T Sigmundsson, O P H Pietiläinen, J E Buizer-Voskamp, E Strengman, C Francks, P Muglia, A Gylfason, O Gustafsson, P I Olason, S Steinberg, T Hansen, K D Jakobsen, H B Rasmussen, I Giegling, H-J Möller, A Hartmann, C Crombie, G Fraser, N Walker, J Lonnqvist, J Suvisaari, A Tuulio-Henriksson, E Bramon, L A Kiemeney, B Franke, R Murray, E Vassos, T Toulopoulou, T W Mühleisen, S Tosato, M Ruggeri, S Djurovic, O A Andreassen, Z Zhang, T Werge, R A Ophoff, M Rietschel, M M Nöthen, H Petursson, H Stefansson, L Peltonen, D Collier, K Stefansson & D M St Clair. (2009) Copy number variations of chromosome 16p13.1 region associated with schizophrenia. Molecular Psychiatry 16:1, pages 17-25.
Crossref
Woo Suk Choi, Byung-Cheon Jeong, Yoo Jin Joo, Myeong-Ryeol Lee, Joon Kim, Michael J Eck & Hyun Kyu Song. (2010) Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases. Nature Structural & Molecular Biology 17:10, pages 1175-1181.
Crossref
Emmanuelle Graciet & Frank Wellmer. (2010) The plant N-end rule pathway: structure and functions. Trends in Plant Science 15:8, pages 447-453.
Crossref
Emmanuelle Graciet, Francesca Mesiti & Frank Wellmer. (2010) Structure and evolutionary conservation of the plant N-end rule pathway. The Plant Journal 61:5, pages 741-751.
Crossref
Haiqing Wang, Konstantin I. Piatkov, Christopher S. Brower & Alexander Varshavsky. (2009) Glutamine-Specific N-Terminal Amidase, a Component of the N-End Rule Pathway. Molecular Cell 34:6, pages 686-695.
Crossref
Shashikanth M. Sriram, Rajkumar Banerjee, Ravi S. Kane & Yong Tae Kwon. (2009) Multivalency-Assisted Control of Intracellular Signaling Pathways: Application for Ubiquitin- Dependent N-End Rule Pathway. Chemistry & Biology 16:2, pages 121-131.
Crossref
Takafumi Tasaki, Adriana Zakrzewska, Drew D. Dudgeon, Yonghua Jiang, John S. Lazo & Yong Tae Kwon. (2009) The Substrate Recognition Domains of the N-end Rule Pathway. Journal of Biological Chemistry 284:3, pages 1884-1895.
Crossref
Samantha JL Knight. 2001. eLS. eLS.
Alexander Varshavsky. (2008) Discovery of Cellular Regulation by Protein Degradation. Journal of Biological Chemistry 283:50, pages 34469-34489.
Crossref
Farkhondeh Behjati, Yousef Shafaghati, Saghar Ghasemi Firouzabadi, Kimia Kahrizi, Iman Bagherizadeh, Hossein Najmabadi, Susan Bint & Caroline Ogilvie. (2008) M-banding characterization of a 16p11.2p13.1 tandem duplication in a child with autism, neurodevelopmental delay and dysmorphism. European Journal of Medical Genetics 51:6, pages 608-614.
Crossref
Zanxian Xia, Ailsa Webster, Fangyong Du, Konstantin Piatkov, Michel Ghislain & Alexander Varshavsky. (2008) Substrate-binding Sites of UBR1, the Ubiquitin Ligase of the N-end Rule Pathway. Journal of Biological Chemistry 283:35, pages 24011-24028.
Crossref
Axel Gödecke, Jürgen Schrader & Michael Reinartz. (2008) Nitric oxide-mediated protein modification in cardiovascular physiology and pathology. PROTEOMICS – CLINICAL APPLICATIONS 2:6, pages 811-822.
Crossref
Min Jae Lee, Krishnendu Pal, Takafumi Tasaki, Sayantani Roy, Yonghua Jiang, Jee Young An, Rajkumar Banerjee & Yong Tae Kwon. (2008) Synthetic heterovalent inhibitors targeting recognition E3 components of the N-end rule pathway. Proceedings of the National Academy of Sciences 105:1, pages 100-105.
Crossref
Takafumi Tasaki & Yong Tae Kwon. (2007) The mammalian N-end rule pathway: new insights into its components and physiological roles. Trends in Biochemical Sciences 32:11, pages 520-528.
Crossref
Reinhard Ullmann, Gillian Turner, Maria Kirchhoff, Wei Chen, Bruce Tonge, Carla Rosenberg, Michael Field, Angela M. Vianna-Morgante, Louise Christie, Ana C. Krepischi-Santos, Lynn Banna, Avril V. Brereton, Alyssa Hill, Anne-Marie Bisgaard, Ines Müller, Claus Hultschig, Fikret Erdogan, Georg Wieczorek & H. Hilger Ropers. (2007) Array CGH identifies reciprocal 16p13.1 duplications and deletions that predispose to autism and/or mental retardation. Human Mutation 28:7, pages 674-682.
Crossref
Takafumi Tasaki, Reinhard Sohr, Zanxian Xia, Rainer Hellweg, Heide Hörtnagl, Alexander Varshavsky & Yong Tae Kwon. (2007) Biochemical and Genetic Studies of UBR3, a Ubiquitin Ligase with a Function in Olfactory and Other Sensory Systems. Journal of Biological Chemistry 282:25, pages 18510-18520.
Crossref
Rong-Gui Hu, Christopher S. Brower, Haiqing Wang, Ilia V. Davydov, Jun Sheng, Jianmin Zhou, Yong Tae Kwon & Alexander Varshavsky. (2006) Arginyltransferase, Its Specificity, Putative Substrates, Bidirectional Promoter, and Splicing-derived Isoforms. Journal of Biological Chemistry 281:43, pages 32559-32573.
Crossref
Yasuaki Goto, Hideo Taniura, Kiyofumi Yamada, Takao Hirai, Noriko Sanada, Noritaka Nakamichi & Yukio Yoneda. (2006) The magnetism responsive gene Ntan1 in mouse brain. Neurochemistry International 49:4, pages 334-341.
Crossref
Linda L Walling. (2006) Recycling or regulation? The role of amino-terminal modifying enzymes. Current Opinion in Plant Biology 9:3, pages 227-233.
Crossref
Jee Young An, Jai Wha Seo, Takafumi Tasaki, Min Jae Lee, Alexander Varshavsky & Yong Tae Kwon. (2006) Impaired neurogenesis and cardiovascular development in mice lacking the E3 ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway. Proceedings of the National Academy of Sciences 103:16, pages 6212-6217.
Crossref
Takao Hirai, Hideo Taniura, Yasuaki Goto, Masato Ogura, Judy C. G. Sng & Yukio Yoneda. (2006) Stimulation of ubiquitin?proteasome pathway through the expression of amidohydrolase for N-terminal asparagine (Ntan1) in cultured rat hippocampal neurons exposed to static magnetism. Journal of Neurochemistry 96:6, pages 1519-1530.
Crossref
Emmanuelle Graciet, Rong-Gui Hu, Konstantin Piatkov, Joon Haeng Rhee, Erich M. Schwarz & Alexander Varshavsky. (2006) Aminoacyl-transferases and the N-end rule pathway of prokaryotic/eukaryotic specificity in a human pathogen. Proceedings of the National Academy of Sciences 103:9, pages 3078-3083.
Crossref
Thierry Meinnel, Alexandre Serero & Carmela Giglione. (2006) Impact of the N-terminal amino acid on targeted protein degradation. Biological Chemistry 387:7.
Crossref
Min Jae Lee, Takafumi Tasaki, Kayoko Moroi, Jee Young An, Sadao Kimura, Ilia V. Davydov & Yong Tae Kwon. (2005) RGS4 and RGS5 are in vivo substrates of the N-end rule pathway . Proceedings of the National Academy of Sciences 102:42, pages 15030-15035.
Crossref
Rong-Gui Hu, Jun Sheng, Xin Qi, Zhenming Xu, Terry T. Takahashi & Alexander Varshavsky. (2005) The N-end rule pathway as a nitric oxide sensor controlling the levels of multiple regulators. Nature 437:7061, pages 981-986.
Crossref
R. Jürgen Dohmen & Alexander Varshavsky. 2005. Ubiquitin and Protein Degradation, Part B. Ubiquitin and Protein Degradation, Part B 799 822 .
Qun Pan, Ofer Shai, Christine Misquitta, Wen Zhang, Arneet L. Saltzman, Naveed Mohammad, Tomas Babak, Henry Siu, Timothy R. Hughes, Quaid D. Morris, Brendan J. Frey & Benjamin J. Blencowe. (2004) Revealing Global Regulatory Features of Mammalian Alternative Splicing Using a Quantitative Microarray Platform. Molecular Cell 16:6, pages 929-941.
Crossref
Aaron Ciechanover & Alan L. Schwartz. (2004) The ubiquitin system: pathogenesis of human diseases and drug targeting. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1695:1-3, pages 3-17.
Crossref
Jinhu Yin, Yong Tae Kwon, Alexander Varshavsky & Weidong Wang. (2004) RECQL4, mutated in the Rothmund–Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway. Human Molecular Genetics 13:20, pages 2421-2430.
Crossref
Susanne StaryXiao-jun YinThomas PotuschakPeter SchlögelhoferVictoria NizhynskaAndreas Bachmair. (2003) PRT1 of Arabidopsis Is a Ubiquitin Protein Ligase of the Plant N-End Rule Pathway with Specificity for Aromatic Amino-Terminal Residues. Plant Physiology 133:3, pages 1360-1366.
Crossref
Mark Ditzel, Rebecca Wilson, Tencho Tenev, Anna Zachariou, Angela Paul, Emma Deas & Pascal Meier. (2003) Degradation of DIAP1 by the N-end rule pathway is essential for regulating apoptosis. Nature Cell Biology 5:5, pages 467-473.
Crossref
Alexander Varshavsky. (2003) The N-end rule and regulation of apoptosis. Nature Cell Biology 5:5, pages 373-376.
Crossref
Sean D Speese, Nick Trotta, Chris K Rodesch, Bharathi Aravamudan & Kendal Broadie. (2003) The Ubiquitin Proteasome System Acutely Regulates Presynaptic Protein Turnover and Synaptic Efficacy. Current Biology 13:11, pages 899-910.
Crossref
Jason C. Mills, Niklas Andersson, Chieu V. Hong, Thaddeus S. Stappenbeck & Jeffrey I. Gordon. (2002) Molecular characterization of mouse gastric epithelial progenitor cells. Proceedings of the National Academy of Sciences 99:23, pages 14819-14824.
Crossref
S. A. Balogh, C. S. McDowell & V. H. Denenberg. (2002) Behavioral characterization of mice lacking the ubiquitin ligase UBR1 of the N-End rule pathway. Genes, Brain and Behavior 1:4, pages 223-229.
Crossref
Fangyong Du, Federico Navarro-Garcia, Zanxian Xia, Takafumi Tasaki & Alexander Varshavsky. (2002) Pairs of dipeptides synergistically activate the binding of substrate by ubiquitin ligase through dissociation of its autoinhibitory domain. Proceedings of the National Academy of Sciences 99:22, pages 14110-14115.
Crossref
Yong Tae KwonAnna S. KashinaIlia V. DavydovRong-Gui HuJee Young AnJai Wha SeoFangyong DuAlexander Varshavsky. (2002) An Essential Role of N-Terminal Arginylation in Cardiovascular Development. Science 297:5578, pages 96-99.
Crossref
Michael H. Glickman & Aaron Ciechanover. (2002) The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction. Physiological Reviews 82:2, pages 373-428.
Crossref
Youming Xie & Alexander Varshavsky. (2001) RPN4 is a ligand, substrate, and transcriptional regulator of the 26S proteasome: A negative feedback circuit. Proceedings of the National Academy of Sciences 98:6, pages 3056-3061.
Crossref
Seth A Balogh, Cary S McDowell, Yong Tae Kwon & Victor H Denenberg. (2001) Facilitated stimulus-response associative learning and long-term memory in mice lacking the NTAN1 amidase of the N-end rule pathway. Brain Research 892:2, pages 336-343.
Crossref
Avram Hershko, Aaron Ciechanover & Alexander Varshavsky. (2000) The ubiquitin system. Nature Medicine 6:10, pages 1073-1081.
Crossref
Seth A. Balogh, Yong Tae Kwon & Victor H. Denenberg. (2000) Varying Intertrial Interval Reveals Temporally Defined Memory Deficits and Enhancements in NTAN1-Deficient Mice. Learning & Memory 7:5, pages 279-286.
Crossref
Victor H. Denenberg. (2000) Evolution Proposes and Ontogeny Disposes. Brain and Language 73:2, pages 274-296.
Crossref
Alexander Varshavsky, Glenn Turner, Fangyong Du & Youming Xie. (2000) The Ubiquitin System and the N-End Rule Pathway. Biological Chemistry 381:9-10.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.