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Molecular and Cellular Biology Volume 20, 2000 - Issue 12
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Nucleocytoplasmic Communication

Yeast Ran-Binding Protein 1 (Yrb1) Shuttles between the Nucleus and Cytoplasm and Is Exported from the Nucleus via a CRM1(XPO1)-Dependent Pathway

Markus Künzler1 Ruprecht-Karls-Universität Heidelberg, Biochemie-Zentrum Heidelberg (BZH)
,
Thomas Gerstberger1 Ruprecht-Karls-Universität Heidelberg, Biochemie-Zentrum Heidelberg (BZH)
,
Françoise Stutz2 Centre Hospitalier Universitaire Vaudois, Microbiologie, CH-1011Lausanne, Switzerland
,
F. Ralf Bischoff3 Abteilung Molekulare Biologie der Mitose, Deutsches Krebsforschungszentrum, D-69120Heidelberg, Germany
&
Ed Hurt1 Ruprecht-Karls-Universität Heidelberg, Biochemie-Zentrum Heidelberg (BZH)Correspondence[email protected]
Pages 4295-4308 | Received 01 Nov 1999, Accepted 29 Mar 2000, Published online: 28 Mar 2023

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Anja Neuber, Jacqueline Franke, Angelika Wittstruck, Gabriel Schlenstedt, Thomas Sommer & Katrin Stade. (2008) Nuclear Export Receptor Xpo1/Crm1 Is Physically and Functionally Linked to the Spindle Pole Body in Budding Yeast. Molecular and Cellular Biology 28:17, pages 5348-5358.
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Mary Miyaji-Yamaguchi, Kohsuke Kato, Ryosuke Nakano, Tomohiro Akashi, Akihiko Kikuchi & Kyosuke Nagata. (2003) Involvement of Nucleocytoplasmic Shuttling of Yeast Nap1 in Mitotic Progression. Molecular and Cellular Biology 23:18, pages 6672-6684.
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Articles from other publishers (47)

Yo-Han Ko, So-Yeon Choi, Kum-Kang So, Jung-Mi Kim, Jeesun Chun & Dae-Hyuk Kim. (2020) Functional analysis of an essential Ran-binding protein gene, CpRbp1, from the chestnut blight fungus Cryphonectria parasitica using heterokaryon rescue. Scientific Reports 10:1.
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Yuling Li, Jinhan Zhou, Sui Min, Yang Zhang, Yuqing Zhang, Qiao Zhou, Xiaofei Shen, Da Jia, Junhong Han & Qingxiang Sun. (2019) Distinct RanBP1 nuclear export and cargo dissociation mechanisms between fungi and animals. eLife 8.
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Yoshiyuki Matsuura. (2016) Mechanistic Insights from Structural Analyses of Ran-GTPase-Driven Nuclear Export of Proteins and RNAs. Journal of Molecular Biology 428:10, pages 2025-2039.
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Zhenhua HuYunmei WangLu YuSanjoy K. MahantyNatalia MendozaElaine A. Elion. (2016) Mapping regions in Ste5 that support Msn5-dependent and -independent nuclear export. Biochemistry and Cell Biology 94:2, pages 109-128.
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Koray Kırlı, Samir Karaca, Heinz Jürgen Dehne, Matthias Samwer, Kuan Ting Pan, Christof Lenz, Henning Urlaub & Dirk Görlich. (2015) A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. eLife 4.
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Neha Kumari, Md. Tajmul & Savita Yadav. (2015) Proteomic Analysis of Mature Lagenaria siceraria Seed. Applied Biochemistry and Biotechnology 175:8, pages 3643-3656.
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Bastien Cautain, Richard Hill, Nuria de Pedro & Wolfgang Link. (2015) Components and regulation of nuclear transport processes. FEBS Journal 282:3, pages 445-462.
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Ho Yee Joyce Fung & Yuh Min Chook. (2014) Atomic basis of CRM1-cargo recognition, release and inhibition. Seminars in Cancer Biology 27, pages 52-61.
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Murray Stewart. 2014. Ras Superfamily Small G Proteins: Biology and Mechanisms 2. Ras Superfamily Small G Proteins: Biology and Mechanisms 2 109 124 .
Francis M Mumbanza, Andrew Kiggundu, Geoffrey Tusiime, Wilberforce K Tushemereirwe, Chuck Niblett & Anna Bailey. (2013) In vitro antifungal activity of synthetic dsRNA molecules against two pathogens of banana, Fusarium oxysporum f. sp. cubense and Mycosphaerella fijiensis . Pest Management Science 69:10, pages 1155-1162.
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Alejandra Fernández-Cid, Montserrat Vega, Pilar Herrero & Fernando Moreno. (2012) Yeast importin-β is required for nuclear import of the Mig2 repressor. BMC Cell Biology 13:1.
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Andrew T. McGuire & Dev Mangroo. (2012) Cex1p Facilitates Rna1p-Mediated Dissociation of the Los1p-tRNA-Gsp1p-GTP Export Complex. Traffic 13:2, pages 234-256.
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Rafael Peláez, Paula Fernández-García, Pilar Herrero & Fernando Moreno. (2012) Nuclear Import of the Yeast Hexokinase 2 Protein Requires α/β-Importin-dependent Pathway. Journal of Biological Chemistry 287:5, pages 3518-3529.
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Soo Jae Lee, Chimari Jiko, Eiki Yamashita & Tomitake Tsukihara. (2011) Selective nuclear export mechanism of small RNAs. Current Opinion in Structural Biology 21:1, pages 101-108.
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Masako Koyama & Yoshiyuki Matsuura. (2010) An allosteric mechanism to displace nuclear export cargo from CRM1 and RanGTP by RanBP1. The EMBO Journal 29:12, pages 2002-2013.
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Thierry G. Lonhienne, Jade K. Forwood, Mary Marfori, Gautier Robin, Bostjan Kobe & Bernard J. Carroll. (2009) Importin-β Is a GDP-to-GTP Exchange Factor of Ran. Journal of Biological Chemistry 284:34, pages 22549-22558.
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Rafael Peláez, Pilar Herrero & Fernando Moreno. (2009) Nuclear Export of the Yeast Hexokinase 2 Protein Requires the Xpo1 (Crm1)-dependent Pathway. Journal of Biological Chemistry 284:31, pages 20548-20555.
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Divyang Jani, Sheila Lutz, Neil J. Marshall, Tamás Fischer, Alwin Köhler, Andrew M. Ellisdon, Ed Hurt & Murray Stewart. (2009) Sus1, Cdc31, and the Sac3 CID Region Form a Conserved Interaction Platform that Promotes Nuclear Pore Association and mRNA Export. Molecular Cell 33:6, pages 727-737.
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Patrick A. Gibney, Thomas Fries, Susanne M. Bailer & Kevin A. Morano. (2008) Rtr1 Is the Saccharomyces cerevisiae Homolog of a Novel Family of RNA Polymerase II-Binding Proteins . Eukaryotic Cell 7:6, pages 938-948.
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A. V. Sorokin, E. R. Kim & L. P. Ovchinnikov. (2007) Nucleocytoplasmic transport of proteins. Biochemistry (Moscow) 72:13, pages 1439-1457.
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Thomas Fries, Christian Betz, Kai Sohn, Stefanie Caesar, Gabriel Schlenstedt & Susanne M. Bailer. (2007) A Novel Conserved Nuclear Localization Signal Is Recognized by a Group of Yeast Importins. Journal of Biological Chemistry 282:27, pages 19292-19301.
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XinXin Quan, Jennifer Yu, Howard Bussey & Ursula Stochaj. (2007) The localization of nuclear exporters of the importin-β family is regulated by Snf1 kinase, nutrient supply and stress. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1773:7, pages 1052-1061.
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Aarti Pandey, Mani Kant Choudhary, Deepti Bhushan, Arnab Chattopadhyay, Subhra Chakraborty, Asis Datta & Niranjan Chakraborty. (2006) The Nuclear Proteome of Chickpea ( Cicer arietinum L.) Reveals Predicted and Unexpected Proteins . Journal of Proteome Research 5:12, pages 3301-3311.
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Shingo Izawa, Kayo Ikeda, Takeomi Kita & Yoshiharu Inoue. (2006) Asr1, an alcohol-responsive factor of Saccharomyces cerevisiae, is dispensable for alcoholic fermentation. Applied Microbiology and Biotechnology 72:3, pages 560-565.
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Hitoshi Nishijima, Jun-ichi Nakayama, Tomoko YoshiokaAyumi KusanoHideo NishitaniKei-ichi Shibahara & Takeharu Nishimoto. (2006) Nuclear RanGAP Is Required for the Heterochromatin Assembly and Is Reciprocally Regulated by Histone H3 and Clr4 Histone Methyltransferase in Schizosaccharomyces pombe . Molecular Biology of the Cell 17:6, pages 2524-2536.
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CHRISTIANE BRUNE, SARAH E. MUNCHEL, NICOLE FISCHER, ALEXANDRE V. PODTELEJNIKOV & KARSTEN WEIS. (2005) Yeast poly(A)-binding protein Pab1 shuttles between the nucleus and the cytoplasm and functions in mRNA export. RNA 11:4, pages 517-531.
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Christian Betz, Gabriel Schlenstedt & Susanne M. Bailer. (2004) Asr1p, a Novel Yeast Ring/PHD Finger Protein, Signals Alcohol Stress to the Nucleus. Journal of Biological Chemistry 279:27, pages 28174-28181.
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Andreas Braunwarth, Micheline Fromont-Racine, Pierre Legrain, F. Ralf Bischoff, Thomas Gerstberger, Ed Hurt & Markus Künzler. (2003) Identification and Characterization of a Novel RanGTP-binding Protein in the Yeast Saccharomyces cerevisiae. Journal of Biological Chemistry 278:17, pages 15397-15405.
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Soo-Hwan Kim & Stanley J. Roux. (2003) An Arabidopsis Ran-binding protein, AtRanBP1c, is a co-activator of Ran GTPase-activating protein and requires the C-terminus for its cytoplasmic localization. Planta 216:6, pages 1047-1052.
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Vikram Govind Panse, Bernhard Küster, Thomas Gerstberger & Ed Hurt. (2002) Unconventional tethering of Ulp1 to the transport channel of the nuclear pore complex by karyopherins. Nature Cell Biology 5:1, pages 21-27.
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Markus Künzler & Ed Hurt. (2001) Targeting of Ran: variation on a common theme?. Journal of Cell Science 114:18, pages 3233-3241.
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Yonchu Jenkins, Patricia V. Sanchez, Barbara E. Meyer & Michael H. Malim. (2001) Nuclear Export of Human Immunodeficiency Virus Type 1 Vpr Is Not Required for Virion Packaging. Journal of Virology 75:17, pages 8348-8352.
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Francisco J. Nicolás, William J. Moore, Chuanmao Zhang & Paul R. Clarke. (2001) XMog1, a nuclear Ran-binding protein in Xenopus , is a functional homologue of Schizosaccharomyces pombe Mog1p that co-operates with RanBP1 to control generation of Ran-GTP . Journal of Cell Science 114:16, pages 3013-3023.
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David J. Dilworth, Adisetyantari Suprapto, Julio C. Padovan, Brian T. Chait, Richard W. Wozniak, Michael P. Rout & John D. Aitchison. (2001) Nup2p Dynamically Associates with the Distal Regions of the Yeast Nuclear Pore Complex. Journal of Cell Biology 153:7, pages 1465-1478.
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Helge Grosshans, Karina Deinert, Ed Hurt & George Simos. (2001) Biogenesis of the Signal Recognition Particle (Srp) Involves Import of Srp Proteins into the Nucleolus, Assembly with the Srp-Rna, and Xpo1p-Mediated Export. Journal of Cell Biology 153:4, pages 745-762.
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Louis Renault, Jürgen Kuhlmann, Andreas Henkel & Alfred Wittinghofer. (2001) Structural Basis for Guanine Nucleotide Exchange on Ran by the Regulator of Chromosome Condensation (RCC1). Cell 105:2, pages 245-255.
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Markus Künzler, Joshua Trueheart, Claudio Sette, Eduard Hurt & Jeremy Thorner. (2001) Mutations in the YRB1 Gene Encoding Yeast Ran-Binding-Protein-1 That Impair Nucleocytoplasmic Transport and Suppress Yeast Mating Defects . Genetics 157:3, pages 1089-1105.
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Patrick MaurerMichael ReddJens SolsbacherF. Ralf BischoffMarkus GreinerAlexandre V. PodtelejnikovMatthias MannKatrin StadeKarsten WeisGabriel Schlenstedt. (2001) The Nuclear Export Receptor Xpo1p Forms Distinct Complexes with NES Transport Substrates and the Yeast Ran Binding Protein 1 (Yrb1p). Molecular Biology of the Cell 12:3, pages 539-549.
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Matthias Bäumer, Markus Künzler, Patrick Steigemann, Gerhard H. Braus & Stefan Irniger. (2000) Yeast Ran-binding Protein Yrb1p Is Required for Efficient Proteolysis of Cell Cycle Regulatory Proteins Pds1p and Sic1p. Journal of Biological Chemistry 275:49, pages 38929-38937.
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