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Molecular and Cellular Biology Volume 20, 2000 - Issue 20
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Cell Growth and Development

Tumor Suppressor p53 Is Required To Modulate BRCA1 Expression

Paz Arizti1 Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, Massachusetts02115
,
Li Fang2 The Derald H. Ruttenberg Cancer Center, The Mount Sinai Medical School, New York, New York10029
,
Iha Park1 Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, Massachusetts02115
,
Yuxin Yin3 Department of Molecular Biology, Princeton University, Princeton, New Jersey08544
,
Ellen Solomon4 Division of Medical and Molecular Genetics, UMDS, Guy's Hospital, LondonSE1 9RT, United Kingdom
,
Toru Ouchi2 The Derald H. Ruttenberg Cancer Center, The Mount Sinai Medical School, New York, New York10029
,
Stuart A. Aaronson2 The Derald H. Ruttenberg Cancer Center, The Mount Sinai Medical School, New York, New York10029
&
Sam W. Lee1 Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, Massachusetts02115Correspondence[email protected]
 show all
Pages 7450-7459 | Received 14 Jun 2000, Accepted 21 Jul 2000, Published online: 28 Mar 2023

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Ruili Yu, Tingyi Sun, Xianwei Zhang, Zhen Li, Yang Xu, Kaihua Liu, Yuqian Shi, Xue Wu, Yang Shao & Lingfei Kong. (2021) TP53 Co-Mutational Features and NGS-Calibrated Immunohistochemistry Threshold in Gastric Cancer. OncoTargets and Therapy 14, pages 4967-4978.
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Donato F. Romagnolo, Ryan B. Chirnomas, Jennifer Ku, Brandon D. Jeffy, Claire M. Payne, Hana Holubec, Lois Ramsey, Harris Bernstein, Carol Bernstein, Kathleen Kunke, Achyut Bhattacharyya, James Warneke & Harinder Garewal. (2003) Deoxycholate, an Endogenous Tumor Promoter and DNA Damaging Agent, Modulates BRCA-1 Expression in Apoptosis-Sensitive Epithelial Cells: Loss of BRCA-1 Expression in Colonic Adenocarcinomas. Nutrition and Cancer 46:1, pages 82-92.
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Timothy K. MacLachlan, Rishu Takimoto & Wafik S. El-Deiry. (2002) BRCA1 Directs a Selective p53-Dependent Transcriptional Response towards Growth Arrest and DNA Repair Targets. Molecular and Cellular Biology 22:12, pages 4280-4292.
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Aye A. Thike, Puay H. Tan, Murasaki Ikeda & Jabed Iqbal. (2016) Increased ID4 expression, accompanied by mutant p53 accumulation and loss of BRCA1/2 proteins in triple-negative breast cancer, adversely affects survival. Histopathology 68:5, pages 702-712.
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HEMANT SARIN. (2016) Conserved molecular mechanisms underlying the effects of small molecule xenobiotic chemotherapeutics on cells. Molecular and Clinical Oncology 4:3, pages 326-368.
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Chao Dong, Fengmei Zhang, Yue Luo, Hui Wang, Xipeng Zhao, Gongshe Guo, Simon N. Powell & Zhihui Feng. (2015) p53 suppresses hyper-recombination by modulating BRCA1 function. DNA Repair 33, pages 60-69.
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Yunguang Sun, Carey Jeanne Myers, Adam Paul Dicker & Bo Lu. (2014) A Novel Radiation-Induced p53 Mutation Is Not Implicated in Radiation Resistance via a Dominant-Negative Effect. PLoS ONE 9:2, pages e87492.
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Matteo Rossi, Oleg N. Demidov, Carl W. Anderson, Ettore Appella & Sharlyn J. Mazur. (2008) Induction of PPM1D following DNA-damaging treatments through a conserved p53 response element coincides with a shift in the use of transcription initiation sites. Nucleic Acids Research 36:22, pages 7168-7180.
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Yukihiko Dan, Yutaka Ohta, Daisuke Tsuchimoto, Mizuki Ohno, Yasuhito Ide, Manabu Sami, Tomomasa Kanda, Kunihiko Sakumi & Yusaku Nakabeppu. (2008) Altered gene expression profiles and higher frequency of spontaneous DNA strand breaks in APEX2-null thymus. DNA Repair 7:9, pages 1437-1454.
Crossref
Hirokuni ShinagawaYoshio MikiKiyotsugu Yoshida. (2008) BRCA1-Mediated Ubiquitination Inhibits Topoisomerase II α Activity in Response to Oxidative Stress . Antioxidants & Redox Signaling 10:5, pages 939-950.
Crossref
Kimberly A. Scata & Wafik S. El-Deiry. 2007. Breast Cancer Chemosensitivity. Breast Cancer Chemosensitivity 70 86 .
Paul B. Mullan, Julia J. Gorski & D. Paul Harkin. (2006) BRCA1—A good predictive marker of drug sensitivity in breast cancer treatment?. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1766:2, pages 205-216.
Crossref
Chen Glait, Dana Ravid, Sam W. Lee, Mordechai Liscovitch & Haim Werner. (2006) Caveolin-1 controls BRCA1 gene expression and cellular localization in human breast cancer cells. FEBS Letters 580:22, pages 5268-5274.
Crossref
Rive Sarfstein, Sharon Maor, Naama Reizner, Shirley Abramovitch & Haim Werner. (2006) Transcriptional regulation of the insulin-like growth factor-I receptor gene in breast cancer. Molecular and Cellular Endocrinology 252:1-2, pages 241-246.
Crossref
Brandon D. Jeffy, Jennifer K. Hockings, Michael Q. Kemp, Sherif S. Morgan, Jill A. Hager, Jason Beliakoff, Luke J. Whitesell, G. Timothy Bowden & Donato F. Romagnolo. (2005) An Estrogen Receptor-α/p300 Complex Activates the BRCA-1 Promoter at an AP-1 Site That Binds Jun/Fos Transcription Factors: Repressive Effects of p53 on BRCA-1 Transcription. Neoplasia 7:9, pages 873-882.
Crossref
D. Wells, M.G. Bermudez, N. Steuerwald, A.R. Thornhill, D.L. Walker, H. Malter, J.D.A. Delhanty & J. Cohen. (2005) Expression of genes regulating chromosome segregation, the cell cycle and apoptosis during human preimplantation development. Human Reproduction 20:5, pages 1339-1348.
Crossref
Timothy MacLachlan & Wafik El-Deiry. 2005. The p53 Tumor Suppressor Pathway and Cancer. The p53 Tumor Suppressor Pathway and Cancer 53 80 .
Susanne Stein, Emily K. Thomas, Birger Herzog, Matthew D. Westfall, Jonathan V. Rocheleau, Roger S. JacksonIIII, Mai Wang & Peng Liang. (2004) NDRG1 Is Necessary for p53-dependent Apoptosis. Journal of Biological Chemistry 279:47, pages 48930-48940.
Crossref
Zhihui Feng, Lisa Kachnic, Junran Zhang, Simon N. Powell & Fen Xia. (2004) DNA Damage Induces p53-dependent BRCA1 Nuclear Export. Journal of Biological Chemistry 279:27, pages 28574-28584.
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Vanesa Garcia, Gemma Domínguez, José M García, Javier Silva, Cristina Peña, José M Silva, Enric Carcereny, Josefa Menendez, Pilar España & Félix Bonilla. (2004) Altered expression of the ZBRK1 gene in human breast carcinomas . The Journal of Pathology 202:2, pages 224-232.
Crossref
Shanthi Adimoolam & James M. Ford. (2003) p53 and regulation of DNA damage recognition during nucleotide excision repair. DNA Repair 2:9, pages 947-954.
Crossref
Kristina Löhr, Constanze Möritz, Ana Contente & Matthias Dobbelstein. (2003) p21/CDKN1A Mediates Negative Regulation of Transcription by p53. Journal of Biological Chemistry 278:35, pages 32507-32516.
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Mel Campbell, Shimian Qu, Sam Wells, Herlina Sugandha & Roy A Jensen. (2003) An adenoviral vector containing an arg–gly–asp (RGD) motif in the fiber knob enhances protein product levels from transgenes refractory to expression. Cancer Gene Therapy 10:7, pages 559-570.
Crossref
Eliot M. Rosen, Saijun Fan, Richard G. Pestell & Itzhak D. Goldberg. (2003) BRCA1 gene in breast cancer. Journal of Cellular Physiology 196:1, pages 19-41.
Crossref
Pat P Ongusaha, Toru Ouchi, Kyung-tae Kim, Emily Nytko, Jennifer C Kwak, Rosemary B Duda, Chu-Xia Deng & Sam W Lee. (2003) BRCA1 shifts p53-mediated cellular outcomes towards irreversible growth arrest. Oncogene 22:24, pages 3749-3758.
Crossref
Matthew T. Canning, David A. Brown & Daniel B. Yarosh. (2003) A Bicyclic Monoterpene Diol and UVB Stimulate BRCA1 Phosphorylation in Human Keratinocytes¶. Photochemistry and Photobiology 77:1, pages 46-51.
Crossref
Dianne C. Daniel. (2002) Highlight: BRCA1 and BRCA2 proteins in breast cancer. Microscopy Research and Technique 59:1, pages 68-83.
Crossref
Xiaoping Sun, Yun Gong, M. Sambasiva Rao & Sunil Badve. (2002) Loss of BRCA1 expression in sporadic male breast carcinoma. Breast Cancer Research and Treatment 71:1, pages 1-7.
Crossref
Brandon D. Jeffy, Ryan B. Chirnomas & Donato F. Romagnolo. (2002) Epigenetics of breast cancer: Polycyclic aromatic hydrocarbons as risk factors. Environmental and Molecular Mutagenesis 39:2-3, pages 235-244.
Crossref
Zoe A. Stewart & Jennifer A. Pietenpol. (2001) p53 Signaling and Cell Cycle Checkpoints. Chemical Research in Toxicology 14:3, pages 243-263.
Crossref
Timothy K. MacLachlan & Wafik S. El-Deiry. (2000) Pointing (zinc) fingers at BRCA1 targets. Nature Medicine 6:12, pages 1318-1319.
Crossref

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