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Molecular and Cellular Biology Volume 20, 2000 - Issue 22
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Transcriptional Regulation

Functional Interaction between Ssu72 and the Rpb2 Subunit of RNA Polymerase II in Saccharomyces cerevisiae

Donald L. Pappas Jr.
&
Michael Hampsey1 Department of Biochemistry, Division of Nucleic Acids Enzymology, Robert Wood Johnson Medical School, Piscataway, New Jersey08854Correspondence[email protected]
Pages 8343-8351 | Received 18 Jul 2000, Accepted 15 Aug 2000, Published online: 28 Mar 2023

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Shankarling Krishnamurthy, Mohamed A. Ghazy, Claire Moore & Michael Hampsey. (2009) Functional Interaction of the Ess1 Prolyl Isomerase with Components of the RNA Polymerase II Initiation and Termination Machineries. Molecular and Cellular Biology 29:11, pages 2925-2934.
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Mariela Reyes-Reyes & Michael Hampsey. (2007) Role for the Ssu72 C-Terminal Domain Phosphatase in RNA Polymerase II Transcription Elongation. Molecular and Cellular Biology 27:3, pages 926-936.
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Bo-Shiun Chen & Michael Hampsey. (2004) Functional Interaction between TFIIB and the Rpb2 Subunit of RNA Polymerase II: Implications for the Mechanism of Transcription Initiation. Molecular and Cellular Biology 24:9, pages 3983-3991.
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Eric J. Steinmetz & David A. Brow. (2003) Ssu72 Protein Mediates Both Poly(A)-Coupled and Poly(A)-Independent Termination of RNA Polymerase II Transcription. Molecular and Cellular Biology 23:18, pages 6339-6349.
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Articles from other publishers (46)

Tingting Zhao, Irina O Vvedenskaya, William KM Lai, Shrabani Basu, B Franklin Pugh, Bryce E Nickels & Craig D Kaplan. (2021) Ssl2/TFIIH function in transcription start site scanning by RNA polymerase II in Saccharomyces cerevisiae. eLife 10.
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Rachael Emily Turner, Paul F Harrison, Angavai Swaminathan, Calvin A Kraupner-Taylor, Belinda J Goldie, Michael See, Amanda L Peterson, Ralf B Schittenhelm, David R Powell, Darren J Creek, Bernhard Dichtl & Traude H Beilharz. (2021) Genetic and pharmacological evidence for kinetic competition between alternative poly(A) sites in yeast. eLife 10.
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Araceli González-Jiménez, Adrián Campos, Francisco Navarro, Andrés Clemente-Blanco & Olga Calvo. (2021) Regulation of Eukaryotic RNAPs Activities by Phosphorylation. Frontiers in Molecular Biosciences 8.
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Suji Lim, Hyojeong Ahn, Ruxin Duan, Yan Liu, Hong-Yeoul Ryu & Seong Hoon Ahn. (2021) The Spt7 subunit of the SAGA complex is required for the regulation of lifespan in both dividing and nondividing yeast cells. Mechanisms of Ageing and Development 196, pages 111480.
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Sarah A. Peck Justice, Neil A. McCracken, José F. Victorino, Guihong D. Qi, Aruna B. Wijeratne & Amber L. Mosley. (2021) Boosting Detection of Low-Abundance Proteins in Thermal Proteome Profiling Experiments by Addition of an Isobaric Trigger Channel to TMT Multiplexes. Analytical Chemistry 93:18, pages 7000-7010.
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Soeun Hwang, Min-Hee Kim & Chang-Woo Lee. (2021) Ssu72 Dual-Specific Protein Phosphatase: From Gene to Diseases. International Journal of Molecular Sciences 22:7, pages 3791.
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Changfu Liu, Weihao Zhang & Wenge Xing. (2020) Diverse and conserved roles of the protein Ssu72 in eukaryotes: from yeast to higher organisms. Current Genetics 67:2, pages 195-206.
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Yi-Ting Wang, Wan-Yi Hsiao & Shao-Win Wang. (2021) The fission yeast Pin1 peptidyl-prolyl isomerase promotes dissociation of Sty1 MAPK from RNA polymerase II and recruits Ssu72 phosphatase to facilitate oxidative stress induced transcription. Nucleic Acids Research 49:2, pages 805-817.
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Paula Allepuz-Fuster, Michael J O’Brien, Noelia González-Polo, Bianca Pereira, Zuzer Dhoondia, Athar Ansari & Olga Calvo. (2019) RNA polymerase II plays an active role in the formation of gene loops through the Rpb4 subunit. Nucleic Acids Research 47:17, pages 8975-8987.
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Benjamin M. Spector, Michael E. Turek & David H. Price. (2019) Functional interaction of human Ssu72 with RNA polymerase II complexes. PLOS ONE 14:3, pages e0213598.
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Sarah R. Offley & Martin C. Schmidt. (2018) Protein phosphatases of Saccharomyces cerevisiae. Current Genetics 65:1, pages 41-55.
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Hannah E. Mischo, Yujin Chun, Kevin M. Harlen, Brendan M. Smalec, Somdutta Dhir, L. Stirling Churchman & Stephen Buratowski. (2018) Cell-Cycle Modulation of Transcription Termination Factor Sen1. Molecular Cell 70:2, pages 312-326.e7.
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Răzvan V. Chereji, Vasudha Bharatula, Nils Elfving, Jeanette Blomberg, Miriam Larsson, Alexandre V. Morozov, James R. Broach & Stefan Björklund. (2017) Mediator binds to boundaries of chromosomal interaction domains and to proteins involved in DNA looping, RNA metabolism, chromatin remodeling, and actin assembly. Nucleic Acids Research 45:15, pages 8806-8821.
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Joshua E. Mayfield, Nathaniel T. Burkholder & Yan Jessie Zhang. (2016) Dephosphorylating eukaryotic RNA polymerase II. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1864:4, pages 372-387.
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Mayuri Rege, Vidya Subramanian, Chenchen Zhu, Tsung-Han S. Hsieh, Assaf Weiner, Nir Friedman, Sandra Clauder-Münster, Lars M. Steinmetz, Oliver J. Rando, Laurie A. Boyer & Craig L. Peterson. (2015) Chromatin Dynamics and the RNA Exosome Function in Concert to Regulate Transcriptional Homeostasis. Cell Reports 13:8, pages 1610-1622.
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Paula Allepuz-Fuster, Verónica Martínez-Fernández, Ana I. Garrido-Godino, Sergio Alonso-Aguado, Steven D. Hanes, Francisco Navarro & Olga Calvo. (2014) Rpb4/7 facilitates RNA polymerase II CTD dephosphorylation. Nucleic Acids Research 42:22, pages 13674-13688.
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Jesús D. Rosado-Lugo & Michael Hampsey. (2014) The Ssu72 Phosphatase Mediates the RNA Polymerase II Initiation-Elongation Transition. Journal of Biological Chemistry 289:49, pages 33916-33926.
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Zhiming Dai, Yuanyan Xiong & Xianhua Dai. (2014) The Pattern and Evolution of Looped Gene Bendability. Molecular Biology and Evolution 31:2, pages 319-329.
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Jeffry L. Corden. (2013) RNA Polymerase II C-Terminal Domain: Tethering Transcription to Transcript and Template. Chemical Reviews 113:11, pages 8423-8455.
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Célia Jeronimo, Alain R. Bataille & François Robert. (2013) The Writers, Readers, and Functions of the RNA Polymerase II C-Terminal Domain Code. Chemical Reviews 113:11, pages 8491-8522.
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Ana M. Rodríguez-Torres, Mónica Lamas-Maceiras, Rosa García-Díaz & María A. Freire-Picos. (2013) Structurally conserved and functionally divergent yeast Ssu72 phosphatases. FEBS Letters 587:16, pages 2617-2622.
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Sue Mei Tan-WongJudith B. ZauggJurgi CamblongZhenyu XuDavid W. ZhangHannah E. MischoAseem Z. AnsariNicholas M. LuscombeLars M. SteinmetzNick J. Proudfoot. (2012) Gene Loops Enhance Transcriptional Directionality. Science 338:6107, pages 671-675.
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Craig D. Kaplan, Huiyan Jin, Ivan Liang Zhang & Andrey Belyanin. (2012) Dissection of Pol II Trigger Loop Function and Pol II Activity–Dependent Control of Start Site Selection In Vivo. PLoS Genetics 8:4, pages e1002627.
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Maria L. Kireeva, Céline Domecq, Benoit Coulombe, Zachary F. Burton & Mikhail Kashlev. (2011) Interaction of RNA Polymerase II Fork Loop 2 with Downstream Non-template DNA Regulates Transcription Elongation. Journal of Biological Chemistry 286:35, pages 30898-30910.
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Michael Hampsey, Badri Nath Singh, Athar Ansari, Jean-Philippe Lainé & Shankarling Krishnamurthy. (2011) Control of eukaryotic gene expression: Gene loops and transcriptional memory. Advances in Enzyme Regulation 51:1, pages 118-125.
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Steve A. Seibold, Badri Nath Singh, Chunfen Zhang, Maria Kireeva, Céline Domecq, Annie Bouchard, Anthony M. Nazione, Michael Feig, Robert I. Cukier, Benoit Coulombe, Mikhail Kashlev, Michael Hampsey & Zachary F. Burton. (2010) Conformational coupling, bridge helix dynamics and active site dehydration in catalysis by RNA polymerase. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1799:8, pages 575-587.
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Céline Domecq, Maria Kireeva, Jacques Archambault, Mikhail Kashlev, Benoit Coulombe & Zachary F. Burton. (2010) Site-directed mutagenesis, purification and assay of Saccharomyces cerevisiae RNA polymerase II. Protein Expression and Purification 69:1, pages 83-90.
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Luis A. Estrella, Miles F. Wilkinson & Carlos I. González. (2009) The Shuttling Protein Npl3 Promotes Translation Termination Accuracy in Saccharomyces cerevisiae. Journal of Molecular Biology 394:3, pages 410-422.
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Sonia Jimeno, Maria García-Rubio, Rosa Luna & Andrés Aguilera. (2008) A reduction in RNA polymerase II initiation rate suppresses hyper-recombination and transcription-elongation impairment of THO mutants. Molecular Genetics and Genomics 280:4, pages 327-336.
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Wensheng Deng & Stefan G. E. Roberts. (2007) TFIIB and the regulation of transcription by RNA polymerase II. Chromosoma 116:5, pages 417-429.
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Carine Ganem, Chaouki Miled, Céline Facca, Jean-Gabriel Valay, Gilles Labesse, Samia Ben Hassine, Carl Mann & Gérard Faye. (2005) Kinase Cak1 functionally interacts with the PAF1 complex and phosphatase Ssu72 via kinases Ctk1 and Bur1. Molecular Genetics and Genomics 275:2, pages 136-147.
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Eduard Nedea, Xiaoyuan He, Minkyu Kim, Jeff Pootoolal, Guoqing Zhong, Veronica Canadien, Timothy Hughes, Stephen Buratowski, Claire L. Moore & Jack Greenblatt. (2003) Organization and Function of APT, a Subcomplex of the Yeast Cleavage and Polyadenylation Factor Involved in the Formation of mRNA and Small Nucleolar RNA 3′-Ends. Journal of Biological Chemistry 278:35, pages 33000-33010.
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Xiaoyuan He, Asad U. Khan, Hailing Cheng, Donald L. PappasJr.Jr., Michael Hampsey & Claire L. Moore. (2003) Functional interactions between the transcription and mRNA 3′ end processing machineries mediated by Ssu72 and Sub1. Genes & Development 17:8, pages 1030-1042.
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Bernhard Dichtl, Diana Blank, Martin Ohnacker, Arno Friedlein, Daniel Roeder, Hanno Langen & Walter Keller. (2002) A Role for SSU72 in Balancing RNA Polymerase II Transcription Elongation and Termination. Molecular Cell 10:5, pages 1139-1150.
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Bo-Shiun Chen, Zu-Wen Sun & Michael Hampsey. (2001) A Gal4-ς54 Hybrid Protein That Functions as a Potent Activator of RNA Polymerase II Transcription in Yeast. Journal of Biological Chemistry 276:26, pages 23881-23887.
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