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Cell Growth and Development

Inhibitory Regulation of Rac Activation, Membrane Ruffling, and Cell Migration by the G Protein-Coupled Sphingosine-1-Phosphate Receptor EDG5 but Not EDG1 or EDG3

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Pages 9247-9261 | Received 18 Apr 2000, Accepted 25 Sep 2000, Published online: 28 Mar 2023

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Eirini Giannoudaki, David J Swan, John A Kirby & Simi Ali. (2012) Sphingosine-1-phosphate signaling as a therapeutic target. Cell Health and Cytoskeleton 4, pages 63-72.
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Jaclyn S. Long, Joanne Edwards, Carol Watson, Sian Tovey, Kirsty M. Mair, Rachel Schiff, Viswanathan Natarajan, Nigel J. Pyne & Susan Pyne. (2010) Sphingosine Kinase 1 Induces Tolerance to Human Epidermal Growth Factor Receptor 2 and Prevents Formation of a Migratory Phenotype in Response to Sphingosine 1-Phosphate in Estrogen Receptor-Positive Breast Cancer Cells. Molecular and Cellular Biology 30:15, pages 3827-3841.
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Michael Maceyka, Sergio E. Alvarez, Sheldon Milstien & Sarah Spiegel. (2008) Filamin A Links Sphingosine Kinase 1 and Sphingosine-1-Phosphate Receptor 1 at Lamellipodia To Orchestrate Cell Migration. Molecular and Cellular Biology 28:18, pages 5687-5697.
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Taketoshi Kajimoto, Taro Okada, Huan Yu, Sravan K. Goparaju, Saleem Jahangeer & Shun-ichi Nakamura. (2007) Involvement of Sphingosine-1-Phosphate in Glutamate Secretion in Hippocampal Neurons. Molecular and Cellular Biology 27:9, pages 3429-3440.
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SANDRA SIEHLER & DANILO GUERINI. (2006) Novel GPCR Screening Approach: Indirect Identification of S1P Receptor Agonists in Antagonist Screening Using a Calcium Assay. Journal of Receptors and Signal Transduction 26:5-6, pages 549-575.
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S. Eigenbrod, R. Derwand, V. Jakl, S. Endres & A. Eigler. (2006) Sphingosine Kinase and Sphingosine-1-Phosphate Regulate Migration, Endocytosis and Apoptosis of Dendritic Cells. Immunological Investigations 35:2, pages 149-165.
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Sravan K. Goparaju, Puneet S. Jolly, Kenneth R. Watterson, Meryem Bektas, Sergio Alvarez, Sukumar Sarkar, Lin Mel, Isao Ishii, Jerold Chun, Sheldon Milstien & Sarah Spiegel. (2005) The S1P2 Receptor Negatively Regulates Platelet-Derived Growth Factor-Induced Motility and Proliferation. Molecular and Cellular Biology 25:10, pages 4237-4249.
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Naotoshi Sugimoto, Noriko Takuwa, Hiroyuki Okamoto, Sotaro Sakurada & Yoh Takuwa. (2003) Inhibitory and Stimulatory Regulation of Rac and Cell Motility by the G12/13-Rho and Gi Pathways Integrated Downstream of a Single G Protein-Coupled Sphingosine-1-Phosphate Receptor Isoform. Molecular and Cellular Biology 23:5, pages 1534-1545.
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