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Cell Growth and Development

A Novel Positive Feedback Loop Mediated by the Docking Protein Gab1 and Phosphatidylinositol 3-Kinase in Epidermal Growth Factor Receptor Signaling

Gerard A. Rodrigues
,
Marco Falasca
,
Zhongtao ZhangDepartment of Pharmacology and Skirball Institute, New York University Medical Center, New York, New York10016
,
Siew Hwa Ong
&
Joseph SchlessingerDepartment of Pharmacology and Skirball Institute, New York University Medical Center, New York, New York10016
Pages 1448-1459 | Received 09 Jun 1999, Accepted 12 Nov 1999, Published online: 28 Mar 2023

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Betty Lamothe, Masashi Yamada, Ute Schaeper, Walter Birchmeier, Irit Lax & Joseph Schlessinger. (2004) The Docking Protein Gab1 Is an Essential Component of an Indirect Mechanism for Fibroblast Growth Factor Stimulation of the Phosphatidylinositol 3-Kinase/Akt Antiapoptotic Pathway. Molecular and Cellular Biology 24:13, pages 5657-5666.
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Marina Holgado-Madruga & Albert J. Wong. (2003) Gab1 Is an Integrator of Cell Death versus Cell Survival Signals in Oxidative Stress. Molecular and Cellular Biology 23:13, pages 4471-4484.
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Si Qing Zhang, William G. Tsiaras, Toshiyuki Araki, Gengyun Wen, Liliana Minichiello, Ruediger Klein & Benjamin G. Neel. (2002) Receptor-Specific Regulation of Phosphatidylinositol 3′-Kinase Activation by the Protein Tyrosine Phosphatase Shp2. Molecular and Cellular Biology 22:12, pages 4062-4072.
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Matthew Wheeler & Jan Domin. (2001) Recruitment of the Class II Phosphoinositide 3-Kinase C2β to the Epidermal Growth Factor Receptor: Role of Grb2. Molecular and Cellular Biology 21:19, pages 6660-6667.
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Laura Simpson, Jing Li, Danny Liaw, Ian Hennessy, Jonathan Oliner, Fred Christians & Ramon Parsons. (2001) PTEN Expression Causes Feedback Upregulation of Insulin Receptor Substrate 2. Molecular and Cellular Biology 21:12, pages 3947-3958.
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Yan Liu, Brendan Jenkins, Jung Lim Shin & Larry R. Rohrschneider. (2001) Scaffolding Protein Gab2 Mediates Differentiation Signaling Downstream of Fms Receptor Tyrosine Kinase. Molecular and Cellular Biology 21:9, pages 3047-3056.
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Christiane R. Maroun, Monica A. Naujokas, Marina Holgado-Madruga, Albert J. Wong & Morag Park. (2000) The Tyrosine Phosphatase SHP-2 Is Required for Sustained Activation of Extracellular Signal-Regulated Kinase and Epithelial Morphogenesis Downstream from the Met Receptor Tyrosine Kinase. Molecular and Cellular Biology 20:22, pages 8513-8525.
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Haihua Gu, Hiroyuki Maeda, James J. Moon, James D. Lord, Monique Yoakim, Brad H. Nelson & Benjamin G. Neel. (2000) New Role for Shc in Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway. Molecular and Cellular Biology 20:19, pages 7109-7120.
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Angel W.-M. Lee & David J. States. (2000) Both Src-Dependent and -Independent Mechanisms Mediate Phosphatidylinositol 3-Kinase Regulation of Colony-Stimulating Factor 1-Activated Mitogen-Activated Protein Kinases in Myeloid Progenitors. Molecular and Cellular Biology 20:18, pages 6779-6798.
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