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Cell Growth and Development

p21-Activated Kinase 1 Plays a Critical Role in Cellular Activation by Nef

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Pages 2619-2627 | Received 02 Sep 1999, Accepted 14 Jan 2000, Published online: 27 Mar 2023

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Zhuo-shen Zhao & Ed Manser. (2012) PAK family kinases. Cellular Logistics 2:2, pages 59-68.
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Julia V Kichina, Anna Goc, Belal Al-Husein, Payaningal R Somanath & Eugene S Kandel. (2010) PAK1 as a therapeutic target. Expert Opinion on Therapeutic Targets 14:7, pages 703-725.
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Scott H Coleman, John R Day & John C Guatelli. (2001) The HIV-1 Nef protein as a target for antiretroviral therapy. Emerging Therapeutic Targets 5:1, pages 1-22.
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J. Singh, L. Ronsard, M. Pandey, R. Kapoor, V. G. Ramachandran & A. C. Banerjea. (2021) Molecular and Genetic Characterization of Natural Variants of HIV-1 Nef Gene from North India and its Functional Implication in Down-Regulation of MHC-I and CD-4. Current HIV Research 19:2, pages 172-187.
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Iratxe del Río-Iñiguez, Elena Vázquez-Chávez, Céline Cuche, Vincenzo Di Bartolo, Jérôme Bouchet & Andrés Alcover. (2018) HIV-1 Nef Hijacks Lck and Rac1 Endosomal Traffic To Dually Modulate Signaling-Mediated and Actin Cytoskeleton–Mediated T Cell Functions. The Journal of Immunology 201:9, pages 2624-2640.
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Alberto Ospina Stella & Stuart Turville. (2018) All-Round Manipulation of the Actin Cytoskeleton by HIV. Viruses 10:2, pages 63.
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Rebecca J. Kaddis Maldonado, Eunice C. Chen & Leslie J. Parent. 2018. Retrovirus-Cell Interactions. Retrovirus-Cell Interactions 527 568 .
Andrea Imle, Bettina Stolp, Verena Böhmer, Matthias Geyer, Erez Raz & Oliver T. Fackler. (2016) D186/D190 is an allele-dependent determinant of HIV-1 Nef function. Virology 498, pages 44-56.
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Andrea Imle, Libin Abraham, Nikolaos Tsopoulidis, Bernard Hoflack, Kalle Saksela & Oliver T. Fackler. (2015) Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex. mBio 6:5.
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Poonam Gupta, Mohammad Husain, Charoo Hans, Hanu Ram, Supriya Singh Verma, Mohammad Misbah, L. S. Chauhan & Arvind Rai. (2014) Sequence heterogeneity in human immunodeficiency virus type 1 nef in patients presenting with rapid progression and delayed progression to AIDS. Archives of Virology 159:9, pages 2303-2320.
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Keren Weiser, Meredith Barton, Dafna Gershoony, Ramanuj DasGupta & Timothy Cardozo. (2013) HIV’s Nef Interacts with β-Catenin of the Wnt Signaling Pathway in HEK293 Cells. PLoS ONE 8:10, pages e77865.
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Tristan J Markle, Philip Mwimanzi & Mark A Brockman. (2013) HIV-1 Nef and T-cell activation: a history of contradictions. Future Virology 8:4, pages 391-404.
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Guihua Sun, Haitang Li, Xiwei Wu, Maricela Covarrubias, Lisa Scherer, Keith Meinking, Brian Luk, Pritsana Chomchan, Jessica Alluin, Adrian F. Gombart & John J. Rossi. (2012) Interplay between HIV-1 infection and host microRNAs. Nucleic Acids Research 40:5, pages 2181-2196.
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Purushottam S. Narute & Thomas E. Smithgall. (2012) Nef Alleles from All Major HIV-1 Clades Activate Src-Family Kinases and Enhance HIV-1 Replication in an Inhibitor-Sensitive Manner. PLoS ONE 7:2, pages e32561.
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Shailendra K Saxena, Gaurav Shrivastava, Sneham Tiwari & Madhavan PN Nair. (2012) HIV-1 Nef: hacker of the host cell. Future Virology 7:2, pages 117-120.
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T. M. Murali, Matthew D. Dyer, David Badger, Brett M. Tyler & Michael G. Katze. (2011) Network-Based Prediction and Analysis of HIV Dependency Factors. PLoS Computational Biology 7:9, pages e1002164.
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Bettina Stolp, Libin Abraham, Jochen M. Rudolph & Oliver T. Fackler. (2010) Lentiviral Nef Proteins Utilize PAK2-Mediated Deregulation of Cofilin as a General Strategy To Interfere with Actin Remodeling. Journal of Virology 84:8, pages 3935-3948.
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Wei Ma, Sasmita Mishra, Niranjala Gajanayaka, Jonathan B. Angel & Ashok Kumar. (2009) HIV-1 Nef Inhibits Lipopolysaccharide-induced IL-12p40 Expression by Inhibiting JNK-activated NFκB in Human Monocytic Cells. Journal of Biological Chemistry 284:12, pages 7578-7587.
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Nathalie J. Arhel & Frank Kirchhoff. 2009. HIV Interactions with Host Cell Proteins. HIV Interactions with Host Cell Proteins 147 175 .
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Susanne Rauch, Kati Pulkkinen, Kalle Saksela & Oliver T. Fackler. (2008) Human Immunodeficiency Virus Type 1 Nef Recruits the Guanine Exchange Factor Vav1 via an Unexpected Interface into Plasma Membrane Microdomains for Association with p21-Activated Kinase 2 Activity. Journal of Virology 82:6, pages 2918-2929.
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Y. Tang & R. Swanstrom. (2008) Development and characterization of a new single cycle vaccine vector in the simian immunodeficiency virus model system. Virology 372:1, pages 72-84.
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Michael Schindler, Devi Rajan, Anke Specht, Carolin Ritter, Kati Pulkkinen, Kalle Saksela & Frank Kirchhoff. (2007) Association of Nef with p21-Activated Kinase 2 Is Dispensable for Efficient Human Immunodeficiency Virus Type 1 Replication and Cytopathicity in Ex Vivo-Infected Human Lymphoid Tissue. Journal of Virology 81:23, pages 13005-13014.
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Massimo Pizzato, Anna HelanderElena PopovaArianna Calistri, Alessia Zamborlini, Giorgio Palù & Heinrich G. Göttlinger. (2007) Dynamin 2 is required for the enhancement of HIV-1 infectivity by Nef. Proceedings of the National Academy of Sciences 104:16, pages 6812-6817.
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Polly R. WalkerMelissa KetunutiIsaac A. ChogeTammy MeyersGlenda GrayEdward C. HolmesLynn Morris. (2007) Polymorphisms in Nef Associated with Different Clinical Outcomes in HIV Type 1 Subtype C-Infected Children. AIDS Research and Human Retroviruses 23:2, pages 204-215.
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Simone I. Giese, Ilka Woerz, Stefanie Homann, Nadine Tibroni, Matthias Geyer & Oliver T. Fackler. (2006) Specific and distinct determinants mediate membrane binding and lipid raft incorporation of HIV-1SF2 Nef. Virology 355:2, pages 175-191.
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Oliver T. Fackler, Arnaud Moris, Nadine Tibroni, Simone I. Giese, Bärbel Glass, Olivier Schwartz & Hans-Georg Kräusslich. (2006) Functional characterization of HIV-1 Nef mutants in the context of viral infection. Virology 351:2, pages 322-339.
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Claudia Haller, Susanne Rauch, Nico Michel, Sebastian Hannemann, Maik J. Lehmann, Oliver T. Keppler & Oliver T. Fackler. (2006) The HIV-1 Pathogenicity Factor Nef Interferes with Maturation of Stimulatory T-lymphocyte Contacts by Modulation of N-Wasp Activity. Journal of Biological Chemistry 281:28, pages 19618-19630.
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Jeremiah F. Roeth & Kathleen L. Collins. (2006) Human Immunodeficiency Virus Type 1 Nef: Adapting to Intracellular Trafficking Pathways. Microbiology and Molecular Biology Reviews 70:2, pages 548-563.
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Patrick Vincent, Elena Priceputu, Denis Kay, Kalle Saksela, Paul Jolicoeur & Zaher Hanna. (2006) Activation of p21-activated Kinase 2 and Its Association with Nef Are Conserved in Murine Cells but Are Not Sufficient to Induce an AIDS-like Disease in CD4C/HIV Transgenic Mice. Journal of Biological Chemistry 281:11, pages 6940-6954.
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Deborah G. Nguyen, Karen C. Wolff, Hong Yin, Jeremy S. Caldwell & Kelli L. Kuhen. (2006) “UnPAKing” Human Immunodeficiency Virus (HIV) Replication: Using Small Interfering RNA Screening To Identify Novel Cofactors and Elucidate the Role of Group I PAKs in HIV Infection. Journal of Virology 80:1, pages 130-137.
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Oliver T Keppler, Nadine Tibroni, Stephanie Venzke, Susanne Rauch & Oliver T Fackler. (2006) Modulation of specific surface receptors and activation sensitization in primary resting CD4+ T lymphocytes by the Nef protein of HIV-1. Journal of Leukocyte Biology 79:3, pages 616-627.
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Alexander Beeser, Zahara M. Jaffer, Clemens Hofmann & Jonathan Chernoff. (2005) Role of Group A p21-activated Kinases in Activation of Extracellular-regulated Kinase by Growth Factors. Journal of Biological Chemistry 280:44, pages 36609-36615.
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Polung Yang & Andrew J. Henderson. (2005) Nef enhances c-Cbl phosphorylation in HIV-infected CD4+ T lymphocytes. Virology 336:2, pages 219-228.
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Sung Bae Lee, Jeehye Park, Jae U. Jung & Jongkyeong Chung. (2005) Nef induces apoptosis by activating JNK signaling pathway and inhibits NF-κB-dependent immune responses in Drosophila. Journal of Cell Science 118:9, pages 1851-1859.
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Oliver T. Keppler, Ina Allespach, Lismarie Schüller, David Fenard, Warner C. Greene & Oliver T. Fackler. (2005) Rodent Cells Support Key Functions of the Human Immunodeficiency Virus Type 1 Pathogenicity Factor Nef. Journal of Virology 79:3, pages 1655-1665.
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Kati Pulkkinen, G. Herma Renkema, Frank Kirchhoff & Kalle Saksela. (2004) Nef Associates with p21-Activated Kinase 2 in a p21-GTPase-Dependent Dynamic Activation Complex within Lipid Rafts. Journal of Virology 78:23, pages 12773-12780.
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Ellen Krautkrämer, Simone I. Giese, Judith E. Gasteier, Walter Muranyi & Oliver T. Fackler. (2004) Human Immunodeficiency Virus Type 1 Nef Activates p21-Activated Kinase via Recruitment into Lipid Rafts. Journal of Virology 78:8, pages 4085-4097.
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Qian Zhan, Qingyuan Ge, Taisuke Ohira, Thomas Van Dyke & John A. Badwey. (2003) p21-Activated Kinase 2 in Neutrophils Can Be Regulated by Phosphorylation at Multiple Sites and by a Variety of Protein Phosphatases. The Journal of Immunology 171:7, pages 3785-3793.
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Gary M. Bokoch. (2003) Biology of the p21-Activated Kinases. Annual Review of Biochemistry 72:1, pages 743-781.
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Minoru Tobiume, Mikako Takahoko, Takeshi Yamada, Masashi Tatsumi, Aikichi Iwamoto & Michiyuki Matsuda. (2002) Inefficient Enhancement of Viral Infectivity and CD4 Downregulation by Human Immunodeficiency Virus Type 1 Nef from Japanese Long-Term Nonprogressors. Journal of Virology 76:12, pages 5959-5965.
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Matthias Geyer, Oliver T. Fackler & B. Matija Peterlin. (2002) Subunit H of the V-ATPase Involved in Endocytosis Shows Homology to β-Adaptins. Molecular Biology of the Cell 13:6, pages 2045-2056.
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Katherine Kedzierska, Philip Ellery, Johnson Mak, Sharon R. Lewin, Suzanne M. Crowe & Anthony Jaworowski. (2002) HIV-1 Down-Modulates γ Signaling Chain of FcγR in Human Macrophages: A Possible Mechanism for Inhibition of Phagocytosis. The Journal of Immunology 168:6, pages 2895-2903.
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Thomas Linnemann, Yong-Hui Zheng, Robert Mandic & B. Matija Peterlin. (2002) Interaction between Nef and Phosphatidylinositol-3-Kinase Leads to Activation of p21-Activated Kinase and Increased Production of HIV. Virology 294:2, pages 246-255.
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Jeffrey A. Schrager, Violette Der Minassian & Jon W. Marsh. (2002) HIV Nef Increases T Cell ERK MAP Kinase Activity. Journal of Biological Chemistry 277:8, pages 6137-6142.
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Oliver T. Fackler, Dietlinde Wolf, H.Oliver Weber, Bernd Laffert, Paola D'Aloja, Beatrice Schuler-Thurner, Rebeca Geffin, Kalle Saksela, Matthias Geyer, B.Matija Peterlin, Gerold Schuler & Andreas S. Baur. (2001) A natural variability in the proline-rich motif of Nef modulates HIV-1 replication in primary T cells. Current Biology 11:16, pages 1294-1299.
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Oliver T. Fackler, Paola d'Aloja, Andreas S. Baur, Maurizio Federico & B. Matija Peterlin. (2001) Nef from Human Immunodeficiency Virus Type 1 F12 Inhibits Viral Production and Infectivity . Journal of Virology 75:14, pages 6601-6608.
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Matthias Geyer, Oliver T Fackler & B Matija Peterlin. (2001) Structure–function relationships in HIV‐1 Nef. EMBO reports 2:7, pages 580-585.
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Alison Simmons, Varuna Aluvihare & Andrew McMichael. (2001) Nef Triggers a Transcriptional Program in T Cells Imitating Single-Signal T Cell Activation and Inducing HIV Virulence Mediators. Immunity 14:6, pages 763-777.
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Chunzhi Xia, Wenbin Ma, Lewis Joe Stafford, Stevan Marcus, Wen-Cheng Xiong & Mingyao Liu. (2001) Regulation of the p21-activated kinase (PAK) by a human Gβ-like WD-repeat protein, hPIP1. Proceedings of the National Academy of Sciences 98:11, pages 6174-6179.
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Jian P. Lian, Alex Toker & John A. Badwey. (2001) Phosphorylation of the Activation Loop of γ p21-Activated Kinase (γ-Pak) and Related Kinases (MSTs) in Normal and Stressed Neutrophils. The Journal of Immunology 166:10, pages 6349-6357.
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Katherine Kedzierska, Johnson Mak, Anthony Jaworowski, Alison Greenway, Antoniette Violo, HiuTat Chan, Jane Hocking, Damian Purcell, John S. Sullivan, John Mills & Suzanne Crowe. (2001) nef-deleted HIV-1 inhibits phagocytosis by monocyte-derived macrophages in vitro but not by peripheral blood monocytes in vivo. AIDS 15:8, pages 945-955.
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G. Herma Renkema, Aki Manninen & Kalle Saksela. (2001) Human Immunodeficiency Virus Type 1 Nef Selectively Associates with a Catalytically Active Subpopulation of p21-Activated Kinase 2 (PAK2) Independently of PAK2 Binding to Nck or β-PIX. Journal of Virology 75:5, pages 2154-2160.
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Jian P. Lian, Lisa Crossley, Qian Zhan, Riyun Huang, Paul Coffer, Alex Toker, Dwight Robinson & John A. Badwey. (2001) Antagonists of Calcium Fluxes and Calmodulin Block Activation of the p21-Activated Protein Kinases in Neutrophils. The Journal of Immunology 166:4, pages 2643-2650.
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