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Molecular and Cellular Biology Volume 20, 2000 - Issue 8
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Gene Expression

The Role of Nuclear Cap Binding Protein Cbc1p of Yeast in mRNA Termination and Degradation

Biswadip Das1 Department of Biochemistry and Biophysics, University of Rochester Medical School, Rochester, New York14642
,
Zijian Guo1 Department of Biochemistry and Biophysics, University of Rochester Medical School, Rochester, New York14642
,
Patrick Russo1 Department of Biochemistry and Biophysics, University of Rochester Medical School, Rochester, New York14642;2 Department of Plant Pathology, Cornell University, Ithaca, New York14853
,
Pascal Chartrand3 Institute for Molecular Medicine, Albert Einstein College of Medicine, Bronx, New York10461
&
Fred Sherman1 Department of Biochemistry and Biophysics, University of Rochester Medical School, Rochester, New York14642Correspondence[email protected]
Pages 2827-2838 | Received 16 Sep 1999, Accepted 16 Jan 2000, Published online: 27 Mar 2023

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Sunirmal Paira, Anish Chakraborty & Biswadip Das. (2023) The Sequential Recruitments of Rab-GTPase Ypt1p and the NNS Complex onto pre-HAC1 mRNA Promote Its Nuclear Degradation in Baker’s Yeast. Molecular and Cellular Biology 43:8, pages 371-400.
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Kenneth S. Zaret. (2014) At the Revolution with Fred Sherman. Molecular and Cellular Biology 34:6, pages 922-925.
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Munshi Azad Hossain, Christina Chung, Suman K. Pradhan & Tracy L. Johnson. (2013) The Yeast Cap Binding Complex Modulates Transcription Factor Recruitment and Establishes Proper Histone H3K36 Trimethylation during Active Transcription. Molecular and Cellular Biology 33:4, pages 785-799.
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Chi-Ming Wong, Hongfang Qiu, Cuihua Hu, Jinsheng Dong & Alan G. Hinnebusch. (2007) Yeast Cap Binding Complex Impedes Recruitment of Cleavage Factor IA to Weak Termination Sites. Molecular and Cellular Biology 27:18, pages 6520-6531.
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Biswadip Das, J. Scott Butler & Fred Sherman. (2003) Degradation of Normal mRNA in the Nucleus of Saccharomyces cerevisiae. Molecular and Cellular Biology 23:16, pages 5502-5515.
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C. M. Hammell, Stefan Gross, Daniel Zenklusen, Catherine V. Heath, Francoise Stutz, Claire Moore & C. N. Cole. (2002) Coupling of Termination, 3′ Processing, and mRNA Export. Molecular and Cellular Biology 22:18, pages 6441-6457.
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Linda McKendrick, Elizabeth Thompson, Joao Ferreira, Simon J. Morley & Joe D. Lewis. (2001) Interaction of Eukaryotic Translation Initiation Factor 4G with the Nuclear Cap-Binding Complex Provides a Link between Nuclear and Cytoplasmic Functions of the m7Guanosine Cap. Molecular and Cellular Biology 21:11, pages 3632-3641.
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Feng He & Allan Jacobson. (2001) Upf1p, Nmd2p, and Upf3p Regulate the Decapping and Exonucleolytic Degradation of both Nonsense-Containing mRNAs and Wild-Type mRNAs. Molecular and Cellular Biology 21:5, pages 1515-1530.
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Articles from other publishers (48)

Yeping Lin, Yunzi Feng, Lin Zheng, Mouming Zhao & Mingtao Huang. (2023) Improved protein production in yeast using cell engineering with genes related to a key factor in the unfolded protein response. Metabolic Engineering 77, pages 152-161.
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Pragyan Singh, Anusha Chaudhuri, Mayukh Banerjea, Neeraja Marathe & Biswadip Das. (2021) Nrd1p identifies aberrant and natural exosomal target messages during the nuclear mRNA surveillance in Saccharomyces cerevisiae . Nucleic Acids Research 49:20, pages 11512-11536.
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Xavier Rambout & Lynne E. Maquat. (2020) The nuclear cap-binding complex as choreographer of gene transcription and pre-mRNA processing. Genes & Development 34:17-18, pages 1113-1127.
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Subhadeep Das, Subir Biswas, Shouvik Chaudhuri, Arindam Bhattacharyya & Biswadip Das. (2019) A Nuclear Zip Code in SKS1 mRNA Promotes Its Slow Export, Nuclear Retention, and Degradation by the Nuclear Exosome/DRN in Saccharomyces cerevisiae. Journal of Molecular Biology 431:19, pages 3626-3646.
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Pragyan Singh, Upasana Saha, Sunirmal Paira & Biswadip Das. (2018) Nuclear mRNA Surveillance Mechanisms: Function and Links to Human Disease. Journal of Molecular Biology 430:14, pages 1993-2013.
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Samuel T Coradetti, Dominic Pinel, Gina M Geiselman, Masakazu Ito, Stephen J Mondo, Morgann C Reilly, Ya-Fang Cheng, Stefan Bauer, Igor V Grigoriev, John M Gladden, Blake A Simmons, Rachel B Brem, Adam P Arkin & Jeffrey M Skerker. (2018) Functional genomics of lipid metabolism in the oleaginous yeast Rhodosporidium toruloides. eLife 7.
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Debasish Sarkar, Sunirmal Paira & Biswadip Das. (2018) Nuclear mRNA degradation tunes the gain of the unfolded protein response in Saccharomyces cerevisiae. Nucleic Acids Research 46:3, pages 1139-1156.
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Arpita Maity, Anusha Chaudhuri & Biswadip Das. (2016) DRN and TRAMP degrade specific and overlapping aberrant mRNAs formed at various stages of mRNP biogenesis in Saccharomyces cerevisiae . FEMS Yeast Research 16:7, pages fow088.
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Satarupa Das & Biswadip Das. (2016) eIF4G—an integrator of mRNA metabolism?. FEMS Yeast Research 16:7, pages fow087.
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Tianlu Li, Nikki De Clercq, Daniel A. Medina, Elena Garre, Per Sunnerhagen, José E. Pérez-Ortín & Paula Alepuz. (2016) The mRNA cap-binding protein Cbc1 is required for high and timely expression of genes by promoting the accumulation of gene-specific activators at promoters. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1859:2, pages 405-419.
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Jesseeca Obenoskey, Dakota R. Lane, Audrey L. Atkin & Bessie W. Kebaara. (2014) Immunity of the Saccharomyces cerevisiae SSY5 mRNA to nonsense-mediated mRNA decay. Frontiers in Molecular Biosciences 1.
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Satarupa Das, Upasana Saha & Biswadip Das. (2014) Cbc2p, Upf3p and eIF4G are components of the DRN (Degradation of mRNA in the Nucleus) in Saccharomyces cerevisiae . FEMS Yeast Research 14:6, pages 922-932.
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Han Liu, Min Luo & Ji-kai Wen. (2014) mRNA stability in the nucleus. Journal of Zhejiang University SCIENCE B 15:5, pages 444-454.
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Thomas Gonatopoulos-PournatzisVictoria H. Cowling. (2013) Cap-binding complex (CBC). Biochemical Journal 457:2, pages 231-242.
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Satarupa Das & Biswadip Das. (2013) mRNA quality control pathways in Saccharomyces cerevisiae. Journal of Biosciences 38:3, pages 615-640.
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Odil Porrua & Domenico Libri. (2013) RNA quality control in the nucleus: The Angels' share of RNA. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1829:6-7, pages 604-611.
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Stephanie Kervestin & Allan Jacobson. (2012) NMD: a multifaceted response to premature translational termination. Nature Reviews Molecular Cell Biology 13:11, pages 700-712.
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Roy Richardson, Clyde L. Denis, Chongxu Zhang, Maria E. O. Nielsen, Yueh-Chin Chiang, Morten Kierkegaard, Xin Wang, Darren J. Lee, Jens S. Andersen & Gang Yao. (2012) Mass spectrometric identification of proteins that interact through specific domains of the poly(A) binding protein. Molecular Genetics and Genomics 287:9, pages 711-730.
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Melissa A. Erce, Chi N. I. Pang, Gene Hart-Smith & Marc R. Wilkins. (2012) The methylproteome and the intracellular methylation network. PROTEOMICS 12:4-5, pages 564-586.
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Elena Garre, Lorena Romero-Santacreu, Nikki De Clercq, Nati Blasco-Angulo, Per Sunnerhagen & Paula Alepuz. (2012) Yeast mRNA cap-binding protein Cbc1/Sto1 is necessary for the rapid reprogramming of translation after hyperosmotic shock. Molecular Biology of the Cell 23:1, pages 137-150.
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Guangwen Lu, Jie Zhang, Yan Li, Zhixin Li, Na Zhang, Xiang Xu, Tingting Wang, Zhenhong Guan, George F. Gao & Jinghua Yan. (2011) hNUDT16: a universal decapping enzyme for small nucleolar RNA and cytoplasmic mRNA. Protein & Cell 2:1, pages 64-73.
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Munshi Azad Hossain, Julia M. Claggett, Tiffany Nguyen & Tracy L. Johnson. (2009) The cap binding complex influences H2B ubiquitination by facilitating splicing of the SUS1 pre-mRNA . RNA 15:8, pages 1515-1527.
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Kelly M. Roth, Joel Byam, Feng Fang & J. Scott Butler. (2009) Regulation of NAB2 mRNA 3′-end formation requires the core exosome and the Trf4p component of the TRAMP complex . RNA 15:6, pages 1045-1058.
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S. Kim, J.-Y. Yang, J. Xu, I.-C. Jang, M. J. Prigge & N.-H. Chua. (2008) Two Cap-Binding Proteins CBP20 and CBP80 are Involved in Processing Primary MicroRNAs. Plant and Cell Physiology 49:11, pages 1634-1644.
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Olaf Isken & Lynne E. Maquat. (2008) The multiple lives of NMD factors: balancing roles in gene and genome regulation. Nature Reviews Genetics 9:9, pages 699-712.
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Mathieu Rougemaille, Tommaso Villa, Rajani Kanth Gudipati & Domenico Libri. (2008) mRNA journey to the cytoplasm: attire required. Biology of the Cell 100:6, pages 327-342.
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Xiaofeng Wu & Yi Wei Jiang. (2008) Overproduction of non-translatable mRNA silences. The transcription ofTy1 retrotransposons inS. cerevisiae via functional inactivation of the nuclear cap-binding complex and subsequent hyperstimulation of the TORC1 pathway. Yeast 25:5, pages 327-347.
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Daiki Matsuda, Nao Hosoda, Yoon Ki Kim & Lynne E Maquat. (2007) Failsafe nonsense-mediated mRNA decay does not detectably target eIF4E-bound mRNA. Nature Structural & Molecular Biology 14:10, pages 974-979.
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Olaf Isken & Lynne E. Maquat. (2007) Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function. Genes & Development 21:15, pages 1833-3856.
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Kathryn L Auld, Amy L Hitchcock, Hugh K Doherty, Seth Frietze, Linda S Huang & Pamela A Silver. (2006) The Conserved ATPase Get3/Arr4 Modulates the Activity of Membrane-Associated Proteins in Saccharomyces cerevisiae . Genetics 174:1, pages 215-227.
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Biswadip Das, Satarupa Das & Fred Sherman. (2006) Mutant LYS2 mRNAs retained and degraded in the nucleus of Saccharomyces cerevisiae . Proceedings of the National Academy of Sciences 103:29, pages 10871-10876.
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N. AmraniS. DongF. HeR. GanesanS. GhoshS. KervestinC. LiD.A. MangusP. SpatrickA. Jacobson. (2006) Aberrant termination triggers nonsense-mediated mRNA decay. Biochemical Society Transactions 34:1, pages 39-42.
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Lidia Vasiljeva & Stephen Buratowski. (2006) Nrd1 Interacts with the Nuclear Exosome for 3′ Processing of RNA Polymerase II Transcripts. Molecular Cell 21:2, pages 239-248.
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Letian Kuai, Biswadip Das & Fred Sherman. (2005) A nuclear degradation pathway controls the abundance of normal mRNAs in Saccharomyces cerevisiae . Proceedings of the National Academy of Sciences 102:39, pages 13962-13967.
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Scott Kuersten & Elizabeth B. Goodwin. (2005) Linking nuclear mRNP assembly and cytoplasmic destiny. Biology of the Cell 97:6, pages 469-478.
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Qinshan Gao, Biswadip Das, Fred Sherman & Lynne E. Maquat. (2005) Cap-binding protein 1-mediated and eukaryotic translation initiation factor 4E-mediated pioneer rounds of translation in yeast. Proceedings of the National Academy of Sciences 102:12, pages 4258-4263.
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Fabrice Lejeune, Aparna C Ranganathan & Lynne E Maquat. (2004) eIF4G is required for the pioneer round of translation in mammalian cells. Nature Structural & Molecular Biology 11:10, pages 992-1000.
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JULIE BARON-BENHAMOU, PURI FORTES, TOSHIFUMI INADA, THOMAS PREISS & MATTHIAS W. HENTZE. (2003) The interaction of the cap-binding complex (CBC) with eIF4G is dispensable for translation in yeast. RNA 9:6, pages 654-662.
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Torben Heick Jensen, Ken Dower, Domenico Libri & Michael Rosbash. (2003) Early Formation of mRNP. Molecular Cell 11:5, pages 1129-1138.
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J.Scott Butler. (2002) The yin and yang of the exosome. Trends in Cell Biology 12:2, pages 90-96.
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Helmut Jungwirth, Helmut Bergler & Gregor Högenauer. (2001) Diazaborine Treatment of Baker's Yeast Results in Stabilization of Aberrant mRNAs. Journal of Biological Chemistry 276:39, pages 36419-36424.
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Yasuhito Ishigaki, Xiaojie Li, Guillaume Serin & Lynne E. Maquat. (2001) Evidence for a Pioneer Round of mRNA Translation. Cell 106:5, pages 607-617.
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Carlos I González, Anirban Bhattacharya, Weirong Wang & Stuart W Peltz. (2001) Nonsense-mediated mRNA decay in Saccharomyces cerevisiae. Gene 274:1-2, pages 15-25.
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Philip Mitchell & David Tollervey. (2001) mRNA turnover. Current Opinion in Cell Biology 13:3, pages 320-325.
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C.I. GONZALEZ, W. WANG & S.W. PELTZ. (2001) Nonsense-mediated mRNA Decay in Saccharomyces cerevisiae: A Quality Control Mechanism That Degrades Transcripts Harboring Premature Termination Codons. Cold Spring Harbor Symposia on Quantitative Biology 66:0, pages 321-328.
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Chris P Ponting. (2000) Novel eIF4G domain homologues linking mRNA translation with nonsense-mediated mRNA decay. Trends in Biochemical Sciences 25:9, pages 423-426.
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