Citations (127)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (11)
Xiaomu Qiao, Isabelle Roth, Eric Féraille & Udo Hasler. (2014) Different effects of ZO-1, ZO-2 and ZO-3 silencing on kidney collecting duct principal cell proliferation and adhesion. Cell Cycle 13:19, pages 3059-3075.
Read now
Read now
Robert L. Kortum, Mario R. Fernandez, Diane L. Costanzo-Garvey, Heidi J. Johnson, Kurt W. Fisher, Deanna J. Volle & Robert E. Lewis. (2014) Caveolin-1 Is Required for Kinase Suppressor of Ras 1 (KSR1)-Mediated Extracellular Signal-Regulated Kinase 1/2 Activation, H-RasV12-Induced Senescence, and Transformation. Molecular and Cellular Biology 34:18, pages 3461-3472.
Read now
Read now
Arvindhan Nagarajan, Shaillay Kumar Dogra, Alex Y. Liu, Michael R. Green & Narendra Wajapeyee. (2014) PEA15 Regulates the DNA Damage-Induced Cell Cycle Checkpoint and Oncogene-Directed Transformation. Molecular and Cellular Biology 34:12, pages 2264-2282.
Read now
Read now
Vidya Bodempudi, Farnaz Yamoutpoor, Weihong Pan, Arkadiusz Z. Dudek, Tuba Esfandyari, Mark Piedra, Dusica Babovick-Vuksanovic, Richard A. Woo, Victor F. Mautner, Lan Kluwe, D. Wade Clapp, George H. De Vries, Stacey L. Thomas, Andreas Kurtz, Luis F. Parada & Faris Farassati. (2009) Ral Overactivation in Malignant Peripheral Nerve Sheath Tumors. Molecular and Cellular Biology 29:14, pages 3964-3974.
Read now
Read now
Mai Xu, Qing Yu, Ramesh Subrahmanyam, Michael J. Difilippantonio, Thomas Ried & Jyoti Misra Sen. (2008) β-Catenin Expression Results in p53-Independent DNA Damage and Oncogene-Induced Senescence in Prelymphomagenic Thymocytes In Vivo. Molecular and Cellular Biology 28:5, pages 1713-1723.
Read now
Read now
Julian Campo-Trapero, Jorge Cano-Sánchez, Begoña Palacios-Sánchez, Silvia Llamas-Martínez, Lorenzo Lo muzio & Antonio Bascones-Martínez. (2008) Cellular senescence in oral cancer and precancer and treatment implications: A review. Acta Oncologica 47:8, pages 1464-1474.
Read now
Read now
Robert L. Kortum, Heidi J. Johnson, Diane L. Costanzo, Deanna J. Volle, Gina L. Razidlo, Angela M. Fusello, Andrey S. Shaw & Robert E. Lewis. (2006) The Molecular Scaffold Kinase Suppressor of Ras 1 Is a Modifier of RasV12-Induced and Replicative Senescence. Molecular and Cellular Biology 26:6, pages 2202-2214.
Read now
Read now
Elizabeth A. Musgrove. (2006) Cyclins: Roles in mitogenic signaling and oncogenic transformation. Growth Factors 24:1, pages 13-19.
Read now
Read now
Frauke Goeman, Dorit Thormeyer, Maria Abad, Manuel Serrano, Oliver Schmidt, Ignacio Palmero & Aria Baniahmad. (2005) Growth Inhibition by the Tumor Suppressor p33ING1 in Immortalized and Primary Cells: Involvement of Two Silencing Domains and Effect of Ras. Molecular and Cellular Biology 25:1, pages 422-431.
Read now
Read now
Kamil R. Kranc, Simon D. Bamforth, José Bragança, Chris Norbury, Maarten van Lohuizen & Shoumo Bhattacharya. (2003) Transcriptional Coactivator Cited2 Induces Bmi1 and Mel18 and Controls Fibroblast Proliferation via Ink4a/ARF. Molecular and Cellular Biology 23:21, pages 7658-7666.
Read now
Read now
Jong-In Park, Christopher J. Strock, Douglas W. Ball & Barry D. Nelkin. (2003) The Ras/Raf/MEK/Extracellular Signal-Regulated Kinase Pathway Induces Autocrine-Paracrine Growth Inhibition via the Leukemia Inhibitory Factor/JAK/STAT Pathway. Molecular and Cellular Biology 23:2, pages 543-554.
Read now
Read now
Articles from other publishers (116)
Laura Gerosa, Amir Mohammad Malvandi, Marco Malavolta, Mauro Provinciali & Giovanni Lombardi. (2023) Exploring cellular senescence in the musculoskeletal system: Any insights for biomarkers discovery?. Ageing Research Reviews 88, pages 101943.
Crossref
Crossref
Tareq Saleh, Ashraf I. Khasawneh, Nisreen Himsawi, Jumana Abu-Raideh, Vera Ejeilat, Ahmed M. Elshazly & David A. Gewirtz. (2022) Senolytic Therapy: A Potential Approach for the Elimination of Oncogene-Induced Senescent HPV-Positive Cells. International Journal of Molecular Sciences 23:24, pages 15512.
Crossref
Crossref
Pavel Galindo-Torres, Cei Abreu-Goodger, Raul Llera-Herrera, Cristina Escobedo-Fregoso, Alejandra García-Gasca & Ana M. Ibarra. (2022) Triploid-induced complete sterility in the scallop Nodipecten subnodosus might be triggered by an early and sustained DNA damage response. Aquaculture 559, pages 738422.
Crossref
Crossref
Tareq Saleh & Valerie J. Carpenter. (2021) Potential Use of Senolytics for Pharmacological Targeting of Precancerous Lesions. Molecular Pharmacology 100:6, pages 580-587.
Crossref
Crossref
Min Hui Park, Jung Eun Choi, Jae-Ryong Kim & Young Kyung Bae. (2021) Immunohistochemical Expressions of Senescence-Associated Secretory Phenotype and Its Association With Immune Microenvironments and Clinicopathological Factors in Invasive Breast Cancer. Pathology and Oncology Research 27.
Crossref
Crossref
Wenbo Yang, Andi Zhang, Yanxin Han, Xiuxiu Su, Yanjia Chen, Weilin Zhao, Ke Yang & Wei Jin. (2021) Cyclin-Dependent Kinase Inhibitor 2b Controls Fibrosis and Functional Changes in Ischemia-Induced Heart Failure via the BMI1-p15-Rb Signalling Pathway. Canadian Journal of Cardiology 37:4, pages 655-664.
Crossref
Crossref
Shahd Fouad, David Hauton & Vincenzo D'Angiolella. (2021) E2F1: Cause and Consequence of DNA Replication Stress. Frontiers in Molecular Biosciences 7.
Crossref
Crossref
Peng Guo, Changsheng Xing, Xiaoying Fu, Dalin He & Jin‐Tang Dong. (2019) Ras inhibits TGF‐β‐induced KLF5 acetylation and transcriptional complex assembly via regulating SMAD2/3 phosphorylation in epithelial cells. Journal of Cellular Biochemistry 121:3, pages 2197-2208.
Crossref
Crossref
Marcos Malumbres. 2020. Abeloff's Clinical Oncology. Abeloff's Clinical Oncology
56
73.e5
.
Meysam Moghbeli. (2019) Genetic and molecular biology of breast cancer among Iranian patients. Journal of Translational Medicine 17:1.
Crossref
Crossref
Robert J. Pignolo, Rebekah M. Samsonraj, Susan F. Law, Haitao Wang & Abhishek Chandra. (2019) Targeting Cell Senescence for the Treatment of Age-Related Bone Loss. Current Osteoporosis Reports 17:2, pages 70-85.
Crossref
Crossref
Jéssica M. Vilas, Carmen Carneiro, Sabela Da Silva-Álvarez, Alba Ferreirós, Patricia González, María Gómez, Sagrario Ortega, Manuel Serrano, Tomás García-Caballero, Miguel González-Barcia, Anxo Vidal & Manuel Collado. (2018) Adult Sox2+ stem cell exhaustion in mice results in cellular senescence and premature aging. Aging Cell 17:5, pages e12834.
Crossref
Crossref
Alejandra Hernandez-Segura, Jamil Nehme & Marco Demaria. (2018) Hallmarks of Cellular Senescence. Trends in Cell Biology 28:6, pages 436-453.
Crossref
Crossref
Chao Yang, Xiaohui Fan & Shuxia Fan. (2018)
Retracted
: Effects and mechanism of puerarin on the human retinoblastoma cells
. Journal of Cellular Biochemistry 119:6, pages 4506-4513.
Crossref
Crossref
Allyson K. Roof & Arthur Gutierrez-Hartmann. (2018) Consider the context: Ras/ERK and PI3K/AKT/mTOR signaling outcomes are pituitary cell type-specific. Molecular and Cellular Endocrinology 463, pages 87-96.
Crossref
Crossref
Yunjie Zhang, Gangcan Li, Xin Liu, Yanping Song, Jia Xie, Guang Li, Jingjing Ren, Hao Wang, Jiao Mou, Jinqian Dai, Feng Liu & Liang Guo. (2018) Sorafenib inhibited cell growth through the MEK/ERK signaling pathway in acute promyelocytic leukemia cells. Oncology Letters.
Crossref
Crossref
Pingping Xiao, Xishi Huang, Lanzhen Huang, Jing Yang, Ang Li, Ke Shen, Philip B. Wedegaertner & Xiaoshan Jiang. (2017) G protein-coupled receptor kinase 4-induced cellular senescence and its senescence-associated gene expression profiling. Experimental Cell Research 360:2, pages 273-280.
Crossref
Crossref
Ségolène Ferratge, Guillaume Ha, Gilles Carpentier, Nassim Arouche, Rümeyza Bascetin, Laurent Muller, Stéphane Germain & Georges Uzan. (2017) Initial clonogenic potential of human endothelial progenitor cells is predictive of their further properties and establishes a functional hierarchy related to immaturity. Stem Cell Research 21, pages 148-159.
Crossref
Crossref
Hae-Ok Byun, Young-Kyoung Lee, Jeong-Min Kim & Gyesoon Yoon. (2016) Erratum to: From cell senescence to age-related diseases: differential mechanisms of action of senescence-associated secretory phenotypes. BMB Reports 49:11, pages 641-650.
Crossref
Crossref
Athanasios Stergiopoulos & Panagiotis K. Politis. (2016) Nuclear receptor NR5A2 controls neural stem cell fate decisions during development. Nature Communications 7:1.
Crossref
Crossref
N. V. Petrova, A. K. Velichko, N. V. Petrova, S. V. Razin & O. L. Kantidze. (2015) Stress factor – dependent differences in molecular mechanisms of premature cell senescence. Biopolymers and Cell 31:5, pages 323-337.
Crossref
Crossref
R K Bikkavilli, S Avasarala, M Van Scoyk, J Arcaroli, C Brzezinski, W Zhang, M G Edwards, M K K Rathinam, T Zhou, J Tauler, S Borowicz, Y A Lussier, B A Parr, C D Cool & R A Winn. (2015) Wnt7a is a novel inducer of β-catenin-independent tumor-suppressive cellular senescence in lung cancer. Oncogene 34:42, pages 5317-5328.
Crossref
Crossref
Dezhi Cheng, Liang Zhao, Yunsheng Xu, Rongying Ou, Gang Li, Han Yang & Wenfeng Li. (2015) K-Ras promotes the non-small lung cancer cells survival by cooperating with sirtuin 1 and p27 under ROS stimulation. Tumor Biology 36:9, pages 7221-7232.
Crossref
Crossref
Shuang Liu, Xinyue Wang, Qian Zhao, Shu Liu, Huishan Zhang, Junchao Shi, Na Li, Xiaohua Lei, Huashan Zhao, Zhili Deng, Yujing Cao, Lina Ning, Guoliang Xia & Enkui Duan. (2015) Senescence of human skin-derived precursors regulated by Akt-FOXO3-p27KIP1/p15INK4b signaling. Cellular and Molecular Life Sciences 72:15, pages 2949-2960.
Crossref
Crossref
Sandra Lazorthes, Céline Vallot, Sébastien Briois, Marion Aguirrebengoa, Jean-Yves Thuret, Georges St. Laurent, Claire Rougeulle, Philipp Kapranov, Carl Mann, Didier Trouche & Estelle Nicolas. (2015) A vlincRNA participates in senescence maintenance by relieving H2AZ-mediated repression at the INK4 locus. Nature Communications 6:1.
Crossref
Crossref
Hasan Zalzali, Bilal Nasr, Mohamad Harajly, Hussein Basma, Farah Ghamloush, Sandra Ghayad, Noël Ghanem, Gerard I Evan & Raya Saab. (2015) CDK2 Transcriptional Repression Is an Essential Effector in p53-Dependent Cellular Senescence—Implications for Therapeutic Intervention. Molecular Cancer Research 13:1, pages 29-40.
Crossref
Crossref
Olga V. Leontieva & Mikhail V. Blagosklonny. (2014) Tumor promoter-induced cellular senescence: cell cycle arrest followed by geroconversion. Oncotarget 5:24, pages 12715-12727.
Crossref
Crossref
Yang Jiang, Yang Shu, Ying Shi, Li-Peng Li, Fei Yuan & Hui Ren. (2014) Identifying Gastric Cancer Related Genes Using the Shortest Path Algorithm and Protein-Protein Interaction Network. BioMed Research International 2014, pages 1-9.
Crossref
Crossref
Marcos Malumbres. 2014. Abeloff's Clinical Oncology. Abeloff's Clinical Oncology
52
68.e6
.
René Huber, Daniel Pietsch, Johannes Günther, Bastian Welz, Nico Vogt & Korbinian Brand. (2013) Regulation of monocyte differentiation by specific signaling modules and associated transcription factor networks. Cellular and Molecular Life Sciences 71:1, pages 63-92.
Crossref
Crossref
Paul M. Campbell. 2014. Cell Cycle Control. Cell Cycle Control
155
163
.
Kwan-Hyuck Baek, Dongha Bhang, Alexander Zaslavsky, Liang-Chuan Wang, Anil Vachani, Carla F. Kim, Steven M. Albelda, Gerard I. Evan & Sandra Ryeom. (2013) Thrombospondin-1 mediates oncogenic Ras–induced senescence in premalignant lung tumors. Journal of Clinical Investigation 123:10, pages 4375-4389.
Crossref
Crossref
Shazia IrshadMukesh BansalMireia Castillo-MartinTian ZhengAlvaro AytesSven WenskeClémentine Le MagnenPaolo GuarnieriPavel SumazinMitchell C. BensonMichael M. ShenAndrea CalifanoCory Abate-Shen. (2013) A Molecular Signature Predictive of Indolent Prostate Cancer. Science Translational Medicine 5:202.
Crossref
Crossref
O V Leontieva, Z N Demidenko & M V Blagosklonny. (2013) MEK drives cyclin D1 hyperelevation during geroconversion. Cell Death & Differentiation 20:9, pages 1241-1249.
Crossref
Crossref
Olga Moiseeva, Xavier Deschênes‐Simard, Emmanuelle St‐Germain, Sebastian Igelmann, Geneviève Huot, Alexandra E. Cadar, Véronique Bourdeau, Michael N. Pollak & Gerardo Ferbeyre. (2013)
Metformin inhibits the senescence‐associated secretory phenotype by interfering with
IKK
/
NF
‐κ
B
activation
. Aging Cell 12:3, pages 489-498.
Crossref
Crossref
J D Ribeiro, L Morey, A Mas, A Gutierrez, N M Luis, S Mejetta, H Richly, S A Benitah, W M Keyes & L Di Croce. (2012) ZRF1 controls oncogene-induced senescence through the INK4-ARF locus. Oncogene 32:17, pages 2161-2168.
Crossref
Crossref
SE-JUNG LEE, DONG HEE RYU, LEE CHAN JANG, SEOK-CHEOL CHO, WUN-JAE KIM & SUNG-KWON MOON. (2013) Suppressive effects of an ethanol extract of Gleditsia sinensis thorns on human SNU-5 gastric cancer cells. Oncology Reports 29:4, pages 1609-1616.
Crossref
Crossref
Satoki Nakamura, Lin Tan, Yasuyuki Nagata, Tomonari Takemura, Aya Asahina, Daisuke Yokota, Tomohiro Yagyu, Kiyoshi Shibata, Shinya Fujisawa & Kazunori Ohnishi. (2013)
JmjC-domain containing histone demethylase 1B-mediated
p15
Ink4b
suppression promotes the proliferation of leukemic progenitor cells through modulation of cell cycle progression in acute myeloid leukemia
. Molecular Carcinogenesis 52:1, pages 57-69.
Crossref
Crossref
Jayson Wang, James Hollingshead, Nabil El-Masry, Donna Horncastle, Ian Talbot, Ian Tomlinson, Malcolm R Alison & Mona El-Bahrawy. (2011) Expression of EGFR, HER2, Phosphorylated ERK and Phosphorylated MEK in Colonic Neoplasms of Familial Adenomatous Polyposis Patients. Journal of Gastrointestinal Cancer 43:3, pages 444-455.
Crossref
Crossref
Bruno Bernardes de JesusMaria A. Blasco. (2012) Assessing Cell and Organ Senescence Biomarkers. Circulation Research 111:1, pages 97-109.
Crossref
Crossref
K. Osei-Sarfo, I. Perez de Castro & A. Pellicer. (2012) p15INK4b plays a crucial role in murine lymphoid development and tumorigenesis. Carcinogenesis 33:3, pages 708-713.
Crossref
Crossref
Se-Jung Lee, Sung-Soo Park, Wun-Jae Kim & Sung-Kwon Moon. (2012)
Gleditsia sinensis
Thorn Extract Inhibits Proliferation and TNF-α-Induced MMP-9 Expression in Vascular Smooth Muscle Cells
. The American Journal of Chinese Medicine 40:02, pages 373-386.
Crossref
Crossref
Yuchen Chien, Claudio Scuoppo, Xiaowo Wang, Xueping Fang, Brian Balgley, Jessica E. Bolden, Prem Premsrirut, Weijun Luo, Agustin Chicas, Cheng S. Lee, Scott C. Kogan & Scott W. Lowe. (2011) Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity. Genes & Development 25:20, pages 2125-2136.
Crossref
Crossref
Prudence H. Tso, Lisa Y. Yung, Yingchun Wang & Yung H. Wong. (2011) RGS19 stimulates cell proliferation by deregulating cell cycle control and enhancing Akt signaling. Cancer Letters 309:2, pages 199-208.
Crossref
Crossref
Y Kotake, T Nakagawa, K Kitagawa, S Suzuki, N Liu, M Kitagawa & Y Xiong. (2010) Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15INK4B tumor suppressor gene. Oncogene 30:16, pages 1956-1962.
Crossref
Crossref
Se-Jung Lee, Keerang Park, Sang-Do Ha, Wun-Jae Kim & Sung-Kwon Moon. (2010)
Gleditsia sinensis
thorn extract inhibits human colon cancer cells: the role of ERK1/2, G2/M-phase cell cycle arrest and p53 expression
. Phytotherapy Research 24:12, pages 1870-1876.
Crossref
Crossref
Jan van Riggelen, Judith Müller, Tobias Otto, Vincent Beuger, Alper Yetil, Peter S. Choi, Christian Kosan, Tarik Möröy, Dean W. Felsher & Martin Eilers. (2010) The interaction between Myc and Miz1 is required to antagonize TGFβ-dependent autocrine signaling during lymphoma formation and maintenance. Genes & Development 24:12, pages 1281-1294.
Crossref
Crossref
Véronique Bourdeau & Gerardo Ferbeyre. 2010. Cellular Senescence and Tumor Suppression. Cellular Senescence and Tumor Suppression
63
83
.
Pinaki Bose, Amudha Ganapathy & Karl Riabowol. 2010. Epigenetics of Aging. Epigenetics of Aging
227
255
.
Michele Milella, Ludovica Ciuffreda & Emilio Bria. 2010. Macromolecular Anticancer Therapeutics. Macromolecular Anticancer Therapeutics
37
83
.
Seung-Keun Hong, Seunghee Yoon, Cas Moelling, Dumrongkiet Arthan & Jong-In Park. (2009) Noncatalytic Function of ERK1/2 Can Promote Raf/MEK/ERK-mediated Growth Arrest Signaling. Journal of Biological Chemistry 284:48, pages 33006-33018.
Crossref
Crossref
Se-Jung Lee, Si-Kwan Kim, Won-Seok Choi, Wun-Jae Kim & Sung-Kwon Moon. (2009) Cordycepin causes p21WAF1-mediated G2/M cell-cycle arrest by regulating c-Jun N-terminal kinase activation in human bladder cancer cells. Archives of Biochemistry and Biophysics 490:2, pages 103-109.
Crossref
Crossref
Baoying Huang, Dayanand Deo, Mingxuan Xia & Lyubomir T. Vassilev. (2009) Pharmacologic p53 Activation Blocks Cell Cycle Progression but Fails to Induce Senescence in Epithelial Cancer Cells. Molecular Cancer Research 7:9, pages 1497-1509.
Crossref
Crossref
Takuya Watanabe, Masumi Tsuda, Shinya Tanaka, Yusuke Ohba, Hideaki Kawaguchi, Tokifumi Majima, Hirofumi Sawa & Akio Minami. (2009) Adaptor Protein Crk Induces Src-Dependent Activation of p38 MAPK in Regulation of Synovial Sarcoma Cell Proliferation. Molecular Cancer Research 7:9, pages 1582-1592.
Crossref
Crossref
Sadeq Vallian, Mandana Sedaghat, Isar Nassiri & Ali Frazmand. (2009) Methylation status of p16 INK4A tumor suppressor gene in Iranian patients with sporadic breast cancer. Journal of Cancer Research and Clinical Oncology 135:8, pages 991-996.
Crossref
Crossref
Jong Kyong Kim & J. Alan Diehl. (2009) Nuclear cyclin D1: An oncogenic driver in human cancer. Journal of Cellular Physiology 220:2, pages 292-296.
Crossref
Crossref
Patricia DeInnocentes, Payal Agarwal & R. Curtis Bird. (2009) Phenotype-rescue of cyclin-dependent kinase inhibitor p16/INK4A defects in a spontaneous canine cell model of breast cancer. Journal of Cellular Biochemistry 106:3, pages 491-505.
Crossref
Crossref
Eo-Jin Lee, Gi-Seong Moon, Won-Seok Choi, Wun-Jae Kim & Sung-Kwon Moon. (2008) Naringin-induced p21WAF1-mediated G1-phase cell cycle arrest via activation of the Ras/Raf/ERK signaling pathway in vascular smooth muscle cells. Food and Chemical Toxicology 46:12, pages 3800-3807.
Crossref
Crossref
C Leikam, A Hufnagel, M Schartl & S Meierjohann. (2008) Oncogene activation in melanocytes links reactive oxygen to multinucleated phenotype and senescence. Oncogene 27:56, pages 7070-7082.
Crossref
Crossref
Gregor Prindull. (2008) Final checkup of neoplastic DNA replication: Evidence for failure in decision-making at the mitotic cell cycle checkpoint G1/S. Experimental Hematology 36:11, pages 1403-1416.
Crossref
Crossref
Eugenia Broude. 2008. Beyond Apoptosis. Beyond Apoptosis
223
249
.
D.-I. Kim, S.-J. Lee, S.-B. Lee, K. Park, W.-J. Kim & S.-K. Moon. (2008) Requirement for Ras/Raf/ERK pathway in naringin-induced G1-cell-cycle arrest via p21WAF1 expression. Carcinogenesis 29:9, pages 1701-1709.
Crossref
Crossref
Se-Jung Lee, Young-Hwa Cho, Keerang Park, Eun-Jung Kim, Kyung-Hwan Jung, Sung-Soo Park, Wun-Jae Kim & Sung-Kwon Moon. (2008) Magnolol elicits activation of the extracellular signal-regulated kinase pathway by inducing p27KIP1-mediated G2/M-phase cell cycle arrest in human urinary bladder cancer 5637 cells. Biochemical Pharmacology 75:12, pages 2289-2300.
Crossref
Crossref
Juan L. Callejas-Valera, Juan Guinea-Viniegra, Carmen Ramírez-Castillejo, Juan A. Recio, Eva Galan-Moya, Natalia Martinez, Jose M. Rojas, Santiago Ramón y Cajal & Ricardo Sánchez-Prieto. (2008) E1a Gene Expression Blocks the ERK1/2 Signaling Pathway by Promoting Nuclear Localization and MKP Up-regulation. Journal of Biological Chemistry 283:19, pages 13450-13458.
Crossref
Crossref
Beobyi Lee, Se-Jung Lee, Sung-Soo Park, Si-Kwan Kim, Sung-Ryong Kim, Jae-Hyun Jung, Wun-Jae Kim & Sung-Kwon Moon. (2008) Sanguinarine-induced G1-phase arrest of the cell cycle results from increased p27KIP1 expression mediated via activation of the Ras/ERK signaling pathway in vascular smooth muscle cells. Archives of Biochemistry and Biophysics 471:2, pages 224-231.
Crossref
Crossref
Marcos Malumbres. 2008. Principles of Molecular Oncology. Principles of Molecular Oncology
207
237
.
José Marín-García, Michael J. Goldenthal & Gordon W. Moe. 2008. Aging and the Heart. Aging and the Heart
149
179
.
T. Arendt. 2008. Handbook of Neurochemistry and Molecular Neurobiology. Handbook of Neurochemistry and Molecular Neurobiology
157
213
.
V Quereda, J Martinalbo, P Dubus, A Carnero & M Malumbres. (2007) Genetic cooperation between p21Cip1 and INK4 inhibitors in cellular senescence and tumor suppression. Oncogene 26:55, pages 7665-7674.
Crossref
Crossref
Takayuki Yamaguchi, Takayuki Yoshida, Reina Kurachi, Junya Kakegawa, Yoshikazu Hori, Toyomichi Nanayama, Kazuhide Hayakawa, Hiroyuki Abe, Koichi Takagi, Youichirou Matsuzaki, Makoto Koyama, Shingo Yogosawa, Yoshihiro Sowa, Takao Yamori, Nobuyuki Tajima & Toshiyuki Sakai. (2007)
Identification of JTP-70902, a p15
INK4b
-inductive compound, as a novel MEK1/2 inhibitor
. Cancer Science 98:11, pages 1809-1816.
Crossref
Crossref
Frédérick A. Mallette, Marie-France Gaumont-Leclerc, Geneviève Huot & Gerardo Ferbeyre. (2007) Myc Down-regulation as a Mechanism to Activate the Rb Pathway in STAT5A-induced Senescence. Journal of Biological Chemistry 282:48, pages 34938-34944.
Crossref
Crossref
Sergio Ruiz-Llorente, Cristina Montero-Conde, Roger L. Milne, Christian M. Moya, Arancha Cebrián, Rocío Letón, Alberto Cascón, Fátima Mercadillo, Iñigo Landa, Salud Borrego, Guiomar Pérez de Nanclares, Cristina Álvarez-Escolá, José Ángel Díaz-Pérez, Ángel Carracedo, Miguel Urioste, Anna González-Neira, Javier Benítez, Pilar Santisteban, Joaquín Dopazo, Bruce A. Ponder & Mercedes Robledo. (2007) Association Study of 69 Genes in the Ret Pathway Identifies Low-penetrance Loci in Sporadic Medullary Thyroid Carcinoma. Cancer Research 67:19, pages 9561-9567.
Crossref
Crossref
James A. McCubrey, Linda S. Steelman, William H. Chappell, Stephen L. Abrams, Ellis W.T. Wong, Fumin Chang, Brian Lehmann, David M. Terrian, Michele Milella, Agostino Tafuri, Franca Stivala, Massimo Libra, Jorg Basecke, Camilla Evangelisti, Alberto M. Martelli & Richard A. Franklin. (2007) Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1773:8, pages 1263-1284.
Crossref
Crossref
M B Miranda & D E Johnson. (2007) Signal transduction pathways that contribute to myeloid differentiation. Leukemia 21:7, pages 1363-1377.
Crossref
Crossref
S Meloche & J Pouysségur. (2007) The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition. Oncogene 26:22, pages 3227-3239.
Crossref
Crossref
Makoto Koyama, Youichirou Matsuzaki, Shingo Yogosawa, Toshiaki Hitomi, Mayumi Kawanaka & Toshiyuki Sakai. (2007) ZD1839 induces p15INK4b and causes G1 arrest by inhibiting the mitogen-activated protein kinase/extracellular signal–regulated kinase pathway. Molecular Cancer Therapeutics 6:5, pages 1579-1587.
Crossref
Crossref
Luni Emdad, Devanand Sarkar, Zao-Zhong Su, Seok-Geun Lee, Dong-Chul Kang, Jeffrey N. Bruce, David J. Volsky & Paul B. Fisher. (2007) Astrocyte elevated gene-1: Recent insights into a novel gene involved in tumor progression, metastasis and neurodegeneration. Pharmacology & Therapeutics 114:2, pages 155-170.
Crossref
Crossref
Toshiaki Hitomi, Youichirou Matsuzaki, Shusuke Yasuda, Mayumi Kawanaka, Shingo Yogosawa, Makoto Koyama, Dean Tantin & Toshiyuki Sakai. (2007)
Oct-1 is involved in the transcriptional repression of the p15
INK4b
gene
. FEBS Letters 581:6, pages 1087-1092.
Crossref
Crossref
James A. McCubrey, Fred E. Bertrand, Linda S. Steelman, Fumin Chang, David M. Terrian & Richard A. Franklin. 2007. Apoptosis, Cell Signaling, and Human Diseases. Apoptosis, Cell Signaling, and Human Diseases
101
134
.
Wen-Sheng Wu, Rong Kung Tsai, Chung Hsing Chang, Sindy Wang, Jia-Ru Wu & Yu-Xun Chang. (2006) Reactive Oxygen Species Mediated Sustained Activation of Protein Kinase C α and Extracellular Signal-Regulated Kinase for Migration of Human Hepatoma Cell Hepg2. Molecular Cancer Research 4:10, pages 747-758.
Crossref
Crossref
Christopher D. Houle, Thai-Vu T. Ton, Natasha Clayton, James Huff, Hue-Hua L. Hong & Robert C. Sills. (2016)
Frequent
p53
and H-
ras
Mutations in Benzene- and Ethylene Oxide-Induced Mammary Gland Carcinomas from B6C3F1 Mice
. Toxicologic Pathology 34:6, pages 752-762.
Crossref
Crossref
Jesús Gil & Gordon Peters. (2006) Regulation of the INK4b–ARF–INK4a tumour suppressor locus: all for one or one for all. Nature Reviews Molecular Cell Biology 7:9, pages 667-677.
Crossref
Crossref
Manuel Collado & Manuel Serrano. (2006) The power and the promise of oncogene-induced senescence markers. Nature Reviews Cancer 6:6, pages 472-476.
Crossref
Crossref
James A. McCubrey, Linda S. Steelman, Steven L. Abrams, John T. Lee, Fumin Chang, Fred E. Bertrand, Patrick M. Navolanic, David M. Terrian, Richard A. Franklin, Antonio B. D’Assoro, Jeffrey L. Salisbury, Maria Clorinda Mazzarino, Franca Stivala & Massimo Libra. (2006) Roles of the RAF/MEK/ERK and PI3K/PTEN/AKT pathways in malignant transformation and drug resistance. Advances in Enzyme Regulation 46:1, pages 249-279.
Crossref
Crossref
Kavita V Bhatt, Laurie S Spofford, Gazelle Aram, Meghan McMullen, Kevin Pumiglia & Andrew E Aplin. (2005) Adhesion control of cyclin D1 and p27Kip1 levels is deregulated in melanoma cells through BRAF-MEK-ERK signaling. Oncogene 24:21, pages 3459-3471.
Crossref
Crossref
Ignacio Pérez de Castro, Marta Benet, María Jiménez, Saba Alzabin, Marcos Malumbres & Angel Pellicer. (2005)
Mouse p10, an Alternative Spliced Form of p15
INK4b
, Inhibits Cell Cycle Progression and Malignant Transformation
. Cancer Research 65:8, pages 3249-3256.
Crossref
Crossref
Toby Passioura, Alla Dolnikov, Sylvie Shen & Geoff Symonds. (2005)
N-Ras
–Induced Growth Suppression of Myeloid Cells Is Mediated by
IRF-1
. Cancer Research 65:3, pages 797-804.
Crossref
Crossref
Eun-Joo Kim, Jong-In Park & Barry D. Nelkin. (2005) IFI16 Is an Essential Mediator of Growth Inhibition, but Not Differentiation, Induced by the Leukemia Inhibitory Factor/JAK/STAT Pathway in Medullary Thyroid Carcinoma Cells. Journal of Biological Chemistry 280:6, pages 4913-4920.
Crossref
Crossref
Jose P. Vaqué, Joaquin Navascues, Yuzuru Shiio, Marikki Laiho, Nuria Ajenjo, Itsaso Mauleon, David Matallanas, Piero Crespo & Javier León. (2005) Myc Antagonizes Ras-mediated Growth Arrest in Leukemia Cells through the Inhibition of the Ras-ERK-p21Cip1 Pathway. Journal of Biological Chemistry 280:2, pages 1112-1122.
Crossref
Crossref
Thomas Arendt. 2005. Cell-Cycle Mechanisms and Neuronal Cell Death. Cell-Cycle Mechanisms and Neuronal Cell Death
1
21
.
María Jiménez, Ignacio Pérez de Castro, Marta Benet, Juan F. García, Giorgio Inghirami & Angel Pellicer. (2004)
The
Rgr
Oncogene Induces Tumorigenesis in Transgenic Mice
. Cancer Research 64:17, pages 6041-6049.
Crossref
Crossref
Martina SchmidtJuraj BiesTomohiko TamuraKeiko OzatoLinda Wolff. (2004) The interferon regulatory factor ICSBP/IRF-8 in combination with PU.1 up-regulates expression of tumor suppressor p15Ink4b in murine myeloid cells. Blood 103:11, pages 4142-4149.
Crossref
Crossref
L S Steelman, S C Pohnert, J G Shelton, R A Franklin, F E Bertrand & J A McCubrey. (2004) JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis. Leukemia 18:2, pages 189-218.
Crossref
Crossref
Hicham Lahlou, Nathalie Saint-Laurent, Jean-Pierre Estève, Alain Eychène, Lucien Pradayrol, Stéphane Pyronnet & Christiane Susini. (2003) sst2 Somatostatin Receptor Inhibits Cell Proliferation through Ras-, Rap1-, and B-Raf-dependent ERK2 Activation. Journal of Biological Chemistry 278:41, pages 39356-39371.
Crossref
Crossref
Naoko Ohtani, Paul Brennan, Stefan Gaubatz, Elaine Sanij, Paul Hertzog, Ernst Wolvetang, Jacques Ghysdael, Martin Rowe & Eiji Hara. (2003) Epstein-Barr virus LMP1 blocks p16INK4a–RB pathway by promoting nuclear export of E2F4/5. Journal of Cell Biology 162:2, pages 173-183.
Crossref
Crossref
F Chang, L S Steelman, J T Lee, J G Shelton, P M Navolanic, W L Blalock, R A Franklin & J A McCubrey. (2003) Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention. Leukemia 17:7, pages 1263-1293.
Crossref
Crossref
Mikhail V Blagosklonny. (2003) Cell senescence and hypermitogenic arrest. EMBO reports 4:4, pages 358-362.
Crossref
Crossref
Mikhail V. Blagosklonny. (2003) Apoptosis, proliferation, differentiation: in search of the order. Seminars in Cancer Biology 13:2, pages 97-105.
Crossref
Crossref
Peter Haviernik, Martina Schmidt, Xinrong Hu & Linda Wolff. (2003) Consistent inactivation of p19Arf but not p15Ink4b in murine myeloid cells transformed in vivo by deregulated c-Myc. Oncogene 22:11, pages 1600-1610.
Crossref
Crossref
Wu Wen-Sheng. (2003) ERK signaling pathway is involved in p15INK4b/p16INK4a expression and HepG2 growth inhibition triggered by TPA and Saikosaponin a. Oncogene 22:7, pages 955-963.
Crossref
Crossref
Xianghong Zou, Dipankar Ray, Aileen Aziyu, Konstantin Christov, Alexander D. Boiko, Andrei V. Gudkov & Hiroaki Kiyokawa. (2002) Cdk4 disruption renders primary mouse cells resistant to oncogenic transformation, leading to Arf/p53-independent senescence. Genes & Development 16:22, pages 2923-2934.
Crossref
Crossref
Catherine L Olsen, Betty Gardie, Paul Yaswen & Martha R Stampfer. (2002) Raf-1-induced growth arrest in human mammary epithelial cells is p16-independent and is overcome in immortal cells during conversion. Oncogene 21:41, pages 6328-6339.
Crossref
Crossref
R. Marcotte & E. Wang. (2002) Replicative Senescence Revisited. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 57:7, pages B257-B269.
Crossref
Crossref
Richard Tomasini, Amina Azizi Samir, Marie-Josèphe Pebusque, Ezequiel L. Calvo, Serena Totaro, Jean Charles Dagorn, Nelson J. Dusetti & Juan L. Iovanna. (2002) p53-dependent expression of the stress-induced protein (SIP). European Journal of Cell Biology 81:5, pages 294-301.
Crossref
Crossref
Sagrario Ortega, Marcos Malumbres & Mariano Barbacid. (2002) Cyclin D-dependent kinases, INK4 inhibitors and cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1602:1, pages 73-87.
Crossref
Crossref
Maya Dajee, Masahito Tarutani, Helen Deng, Ti Cai & Paul A Khavari. (2002) Epidermal Ras blockade demonstrates spatially localized Ras promotion of proliferation and inhibition of differentiation. Oncogene 21:10, pages 1527-1538.
Crossref
Crossref
Lawrence A Quilliam, John F Rebhun & Ariel F Castro. 2002.
391
444
.
Takao Watanabe, Hideaki Yokoo, Minako Yokoo, Yasuhiro Yonekawa, Paul Kleihues & Hiroko Ohgaki. (2001) Concurrent Inactivation of RB1 and TP53 Pathways in Anaplastic Oligodendrogliomas. Journal of Neuropathology & Experimental Neurology 60:12, pages 1181-1189.
Crossref
Crossref
Peter Muscarella, Thomas J. Knobloch, Alexis B. Ulrich, Bruce C. Casto, Nicolas Moniaux, Uwe A. Wittel, W.Scott Melvin, Parviz M. Pour, Huijuan Song, Barry Gold, Surinder K. Batra & Christopher M. Weghorst. (2001) Identification and sequencing of the Syrian Golden hamster (Mesocricetus auratus) p16INK4a and p15INK4b cDNAs and their homozygous gene deletion in cheek pouch and pancreatic tumor cells. Gene 278:1-2, pages 235-243.
Crossref
Crossref
Martina Schmidt, Richard Koller, Peter Haviernik, Juraj Bies, Karolina Maciag & Linda Wolff. (2001) Deregulated c-Myb expression in murine myeloid leukemias prevents the up-regulation of p15INK4b normally associated with differentiation. Oncogene 20:43, pages 6205-6214.
Crossref
Crossref
Athena W. Lin & Scott W. Lowe. (2001)
Oncogenic
ras
activates the ARF-p53 pathway to suppress epithelial cell transformation
. Proceedings of the National Academy of Sciences 98:9, pages 5025-5030.
Crossref
Crossref
Peter Staller, Karen Peukert, Astrid Kiermaier, Joan Seoane, Jiri Lukas, Holger Karsunky, Tarik Möröy, Jiri Bartek, Joan Massagué, Frank Hänel & Martin Eilers. (2001) Repression of p15INK4b expression by Myc through association with Miz-1. Nature Cell Biology 3:4, pages 392-399.
Crossref
Crossref
Martin McMahon & Douglas Woods. (2001) Regulation of the p53 pathway by Ras, the plot thickens. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1471:2, pages M63-M71.
Crossref
Crossref
Ante S Lundberg, William C Hahn, Piyush Gupta & Robert A Weinberg. (2000) Genes involved in senescence and immortalization. Current Opinion in Cell Biology 12:6, pages 705-709.
Crossref
Crossref
Gerardo Ferbeyre, Elisa de Stanchina, Emmanuelle Querido, Nicole Baptiste, Carol Prives & Scott W. Lowe. (2000)
PML is induced by oncogenic
ras
and promotes premature senescence
. Genes & Development 14:16, pages 2015-2027.
Crossref
Crossref
Marcos Malumbres, Sagrario Ortega & Mariano Barbacid. (2000) Genetic Analysis of Mammalian Cyclin-Dependent Kinases and Their Inhibitors. Biological Chemistry 381:9-10.
Crossref
Crossref