72
Views
205
CrossRef citations to date
0
Altmetric
Cell Growth and Development

Protein Kinase C-θ Participates in NF-κB Activation Induced by CD3-CD28 Costimulation through Selective Activation of IκB Kinase β

, , , &
Pages 2933-2940 | Received 08 Sep 1999, Accepted 10 Jan 2000, Published online: 27 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

Anjum Zafar, Fan Wu, Kristine Hardy, Jasmine Li, Wen Juan Tu, Robert McCuaig, Janelle Harris, Kum Kum Khanna, Joanne Attema, Philip A. Gregory, Gregory J. Goodall, Kirsti Harrington, Jane E. Dahlstrom, Tara Boulding, Rebecca Madden, Abel Tan, Peter J. Milburn & Sudha Rao. (2014) Chromatinized Protein Kinase C-θ Directly Regulates Inducible Genes in Epithelial to Mesenchymal Transition and Breast Cancer Stem Cells. Molecular and Cellular Biology 34:16, pages 2961-2980.
Read now
Jean-Damien Charrier & Ronald MA Knegtel. (2013) Advances in the design of ITK inhibitors. Expert Opinion on Drug Discovery 8:4, pages 369-381.
Read now
Erika Scharschmidt, Elmar Wegener, Vigo Heissmeyer, Anjana Rao & Daniel Krappmann. (2004) Degradation of Bcl10 Induced by T-Cell Activation Negatively Regulates NF-κB Signaling. Molecular and Cellular Biology 24:9, pages 3860-3873.
Read now
Peter Storz, Heike Döppler & Alex Toker. (2004) Protein Kinase Cδ Selectively Regulates Protein Kinase D-Dependent Activation of NF-κB in Oxidative Stress Signaling. Molecular and Cellular Biology 24:7, pages 2614-2626.
Read now
Donghai Wang, Reiko Matsumoto, Yun You, Tuanjie Che, Xue-Yan Lin, Sarah L. Gaffen & Xin Lin. (2004) CD3/CD28 Costimulation-Induced NF-κB Activation Is Mediated by Recruitment of Protein Kinase C-θ, Bcl10, and IκB Kinase β to the Immunological Synapse through CARMA1. Molecular and Cellular Biology 24:1, pages 164-171.
Read now
Sergey A. Trushin, Kevin N. Pennington, Eva M. Carmona, Susana Asin, Doris N. Savoy, Daniel D. Billadeau & Carlos V. Paya. (2003) Protein Kinase Cα (PKCα) Acts Upstream of PKCθ To Activate IκB Kinase and NF-κB in T Lymphocytes. Molecular and Cellular Biology 23:19, pages 7068-7081.
Read now
Alain Lilienbaum & Alain Israël. (2003) From Calcium to NF-κB Signaling Pathways in Neurons. Molecular and Cellular Biology 23:8, pages 2680-2698.
Read now
Daniel Krappmann, Alina Patke, Vigo Heissmeyer & Claus Scheidereit. (2001) B-Cell Receptor- and Phorbol Ester-Induced NF-κB and c-Jun N-Terminal Kinase Activation in B Cells Requires Novel Protein Kinase C's. Molecular and Cellular Biology 21:19, pages 6640-6650.
Read now
Arshad Rahman, Khandaker N. Anwar, Shahab Uddin, Ning Xu, Richard D. Ye, Leonidas C. Platanias & Asrar B. Malik. (2001) Protein Kinase C-δ Regulates Thrombin-Induced ICAM-1 Gene Expression in Endothelial Cells via Activation of p38 Mitogen-Activated Protein Kinase. Molecular and Cellular Biology 21:16, pages 5554-5565.
Read now

Articles from other publishers (196)

Kim M. A. De Kleijn, Kirsten R. Straasheijm, Wieteke A. Zuure & Gerard J. M. Martens. (2022) Molecular Signature of Neuroinflammation Induced in Cytokine-Stimulated Human Cortical Spheroids. Biomedicines 10:5, pages 1025.
Crossref
Kyung-Ho Jung, Jin Hee Lee, Mina Kim, Young Seok Cho & Kyung-Han Lee. (2022) 89Zr Immuno-PET Imaging of Tumor PD-1 Reveals That PMA Upregulates Lymphoma PD-1 through NFκB and JNK Signaling. Molecular Imaging 2022, pages 1-13.
Crossref
Uri Mbonye, Konstantin Leskov, Meenakshi Shukla, Saba Valadkhan & Jonathan Karn. (2021) Biogenesis of P-TEFb in CD4+ T cells to reverse HIV latency is mediated by protein kinase C (PKC)-independent signaling pathways. PLOS Pathogens 17:9, pages e1009581.
Crossref
Beibei Wu, Jin Seok Woo, Pamela Vila, Marcus Jew, Jennifer Leung, Zuoming Sun, Sonal Srikanth & Yousang Gwack. (2021) NKD2 mediates stimulation-dependent ORAI1 trafficking to augment Ca2+ entry in T cells. Cell Reports 36:8, pages 109603.
Crossref
Yujiao He, Zhiguo Yang, Chen-si Zhao, Zhihui Xiao, Yu Gong, Yun-Yi Li, Yiqi Chen, Yunting Du, Dianying Feng, Amnon Altman & Yingqiu Li. (2021) T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1. eLife 10.
Crossref
Hyunju Oh, Jingyao Zhao, Yenkel Grinberg-Bleyer, Thomas S. Postler, Pingzhang Wang, Sung-Gyoo Park, Raul Rabadan, Matthew S. Hayden & Sankar Ghosh. (2021) PDK1 Is Required for Maintenance of CD4+ Foxp3+ Regulatory T Cell Function. The Journal of Immunology 206:8, pages 1776-1783.
Crossref
Jason K. Cullen, Glen M. Boyle, Pei-Yi Yap, Stefan Elmlinger, Jacinta L. Simmons, Natasa Broit, Jenny Johns, Blake Ferguson, Lidia A. Maslovskaya, Andrei I. Savchenko, Paul Malek Mirzayans, Achim Porzelle, Paul V. Bernhardt, Victoria A. Gordon, Paul W. Reddell, Alberto Pagani, Giovanni Appendino, Peter G. Parsons & Craig M. Williams. (2021) Activation of PKC supports the anticancer activity of tigilanol tiglate and related epoxytiglianes. Scientific Reports 11:1.
Crossref
Zhaoqing Hu, Lin Li, Banghui Zhu, Yi Huang, Xinran Wang, Xiaolei Lin, Maoxia Li, Peipei Xu, Xuerui Zhang, Jing Zhang & Zichun Hua. (2020) Annexin A5 is essential for PKCθ translocation during T-cell activation. Journal of Biological Chemistry 295:41, pages 14214-14221.
Crossref
Natalia González-Mancha & Isabel Mérida. (2020) Interplay Between SNX27 and DAG Metabolism in the Control of Trafficking and Signaling at the IS. International Journal of Molecular Sciences 21:12, pages 4254.
Crossref
Kee Siang Lim, Zachary Wei Ern Yong, Huajing Wang, Tuan Zea Tan, Ruby Yun-Ju Huang, Daisuke Yamamoto, Noriyuki Inaki, Masaharu Hazawa, Richard W. Wong, Hiroko Oshima, Masanobu Oshima, Yoshiaki Ito & Dominic Chih-Cheng Voon. (2020) Inflammatory and mitogenic signals drive interleukin 23 subunit alpha (IL23A) secretion independent of IL12B in intestinal epithelial cells. Journal of Biological Chemistry 295:19, pages 6387-6400.
Crossref
Jeong-Ryul Hwang, Yeongseon Byeon, Donghwan Kim & Sung-Gyoo Park. (2020) Recent insights of T cell receptor-mediated signaling pathways for T cell activation and development. Experimental & Molecular Medicine 52:5, pages 750-761.
Crossref
Isabella Palazzo, Kyle Deistler, Thanh V. Hoang, Seth Blackshaw & Andy J. Fischer. (2020) NF-κB signaling regulates the formation of proliferating Müller glia-derived progenitor cells in the avian retina. Development.
Crossref
Alexandre M. Carmo & Sónia N. Henriques. 2020. Tissue-Specific Cell Signaling. Tissue-Specific Cell Signaling 133 161 .
Yalu Liu, Xiaogan Wang, Lijuan Deng, Lingyan Ping, Yunfei Shi, Wen Zheng, Ningjing Lin, Xiaopei Wang, Meifeng Tu, Yan Xie, Weiping Liu, Zhitao Ying, Chen Zhang, Zhengying Pan, Xi Wang, Ning Ding, Yuqin Song & Jun Zhu. (2019) ITK inhibition induced in vitro and in vivo anti-tumor activity through downregulating TCR signaling pathway in malignant T cell lymphoma. Cancer Cell International 19:1.
Crossref
Darienne R. Myers, Benjamin Wheeler & Jeroen P. Roose. (2019) mTOR and other effector kinase signals that impact T cell function and activity. Immunological Reviews 291:1, pages 134-153.
Crossref
Jiji Xie, Xuemei HanChensi ZhaoAnn J. Canonigo-Balancio, John R. YatesIIIIII, Yingqiu LiBjörn F. LillemeierAmnon Altman. (2019) Phosphotyrosine-dependent interaction between the kinases PKCθ and Zap70 promotes proximal TCR signaling. Science Signaling 12:577.
Crossref
Zhi-long Chen, Bei-Ni Gong, Qi-long Wang, Zhi-hui Xiao, Chong Deng, Wen-qian Wang & Yingqiu Li. (2019) Characterisation of amphioxus protein kinase C-δ/θ reveals a unique proto-V3 domain suggesting an evolutionary mechanism for PKC-θ unique V3. Fish & Shellfish Immunology 84, pages 1100-1107.
Crossref
Shuhei Ogawa & Ryo Abe. 2019. Co-signal Molecules in T Cell Activation. Co-signal Molecules in T Cell Activation 85 133 .
Haoyang Wang, Cong Wang, Limin Wang, Tiantian Liu, Zhiqiang Wang, Hongjie You, Yuanyuan Zheng & Dali Luo. (2018) Orai1 downregulation impairs lymphocyte function in type 2 diabetes mellitus. Biochemical and Biophysical Research Communications 500:2, pages 384-390.
Crossref
Liron DavidYang LiJun MaEthan Garner, Xinzheng ZhangHao Wu. (2018) Assembly mechanism of the CARMA1–BCL10–MALT1–TRAF6 signalosome. Proceedings of the National Academy of Sciences 115:7, pages 1499-1504.
Crossref
Luis Ulloa, Salvador Quiroz-Gonzalez & Rafael Torres-Rosas. (2017) Nerve Stimulation: Immunomodulation and Control of Inflammation. Trends in Molecular Medicine 23:12, pages 1103-1120.
Crossref
Antonia Ávila‐Flores, Javier Arranz‐Nicolás, Elena Andrada, Denise Soutar & Isabel Mérida. (2017) Predominant contribution of DGKζ over DGKα in the control of PKC/PDK‐1‐regulated functions in T cells. Immunology & Cell Biology 95:6, pages 549-563.
Crossref
Wen Juan Tu, Kristine Hardy, Christopher R. Sutton, Robert McCuaig, Jasmine Li, Jenny Dunn, Abel Tan, Vedran Brezar, Melanie Morris, Gareth Denyer, Sau Kuen Lee, Stephen J. Turner, Nabila Seddiki, Corey Smith, Rajiv Khanna & Sudha Rao. (2017) Priming of transcriptional memory responses via the chromatin accessibility landscape in T cells. Scientific Reports 7:1.
Crossref
Sonal Srikanth, Jin Seok Woo, Zuoming Sun & Yousang Gwack. 2017. Store-Operated Ca²⁺ Entry (SOCE) Pathways. Store-Operated Ca²⁺ Entry (SOCE) Pathways 397 424 .
Matija Hedl & Clara Abraham. (2016) A TPL2 (MAP3K8) disease-risk polymorphism increases TPL2 expression thereby leading to increased pattern recognition receptor-initiated caspase-1 and caspase-8 activation, signalling and cytokine secretion . Gut 65:11, pages 1799-1811.
Crossref
Marcos Roberto de Oliveira. (2016) Evidence for genistein as a mitochondriotropic molecule. Mitochondrion 29, pages 35-44.
Crossref
Jonathan H. Esensten, Ynes A. Helou, Gaurav Chopra, Arthur Weiss & Jeffrey A. Bluestone. (2016) CD28 Costimulation: From Mechanism to Therapy. Immunity 44:5, pages 973-988.
Crossref
Edwina Naik & Vishva M. Dixit. (2016) Usp9X Is Required for Lymphocyte Activation and Homeostasis through Its Control of ZAP70 Ubiquitination and PKCβ Kinase Activity. The Journal of Immunology 196:8, pages 3438-3451.
Crossref
Sae Mi Wi, Yoon Min & Ki-Young Lee. (2016) Charged MVB protein 5 is involved in T-cell receptor signaling. Experimental & Molecular Medicine 48:1, pages e206-e206.
Crossref
Hoibin JeongSeoyeon BokBeom-Ju HongHyung-Seok ChoiG-One Ahn. (2016) Radiation-induced immune responses: mechanisms and therapeutic perspectives. Blood Research 51:3, pages 157.
Crossref
Darienne R. Myers & Jeroen P. Roose. 2016. Encyclopedia of Immunobiology. Encyclopedia of Immunobiology 25 37 .
Gary S. Ma, Inmaculada Lopez-Sanchez, Nicolas Aznar, Nicholas Kalogriopoulos, Shabnam Pedram, Krishna Midde, Theodore P. Ciaraldi, Robert R. Henry & Pradipta Ghosh. (2015) Activation of G proteins by GIV-GEF is a pivot point for insulin resistance and sensitivity. Molecular Biology of the Cell 26:23, pages 4209-4223.
Crossref
Xu-Dong Wang, Yu Gong, Zhi-Long Chen, Bei-Ni Gong, Ji-Ji Xie, Chuan-Qi Zhong, Qi-Long Wang, Liang-Hui Diao, Anlong Xu, Jiahuai Han, Amnon Altman & Yingqiu Li. (2015) TCR-induced sumoylation of the kinase PKC-θ controls T cell synapse organization and T cell activation. Nature Immunology 16:11, pages 1195-1203.
Crossref
Vedran Brezar, Wen Juan Tu & Nabila Seddiki. (2015) PKC-Theta in Regulatory and Effector T-cell Functions. Frontiers in Immunology 6.
Crossref
Hidehiko Fukahori, Noboru Chida, Masashi Maeda, Mamoru Tasaki, Tomoko Kawashima, Takahisa Noto, Susumu Tsujimoto, Koji Nakamura, Shinsuke Oshima, Jun Hirose, Yasuyuki Higashi & Tatsuaki Morokata. (2015) Effect of novel PKCθ selective inhibitor AS2521780 on acute rejection in rat and non-human primate models of transplantation. International Immunopharmacology 27:2, pages 232-237.
Crossref
Rouba Hage-Sleiman, Asmaa B. Hamze, Lina Reslan, Hadile Kobeissy & Ghassan Dbaibo. (2015) The Novel PKC θ from Benchtop to Clinic . Journal of Immunology Research 2015, pages 1-16.
Crossref
Adam CurnockClare BoltonPeter ChiuElisabeth DoyleDamien FraysseMatthias HesseJulie JonesPeter WeberJuan-Miguel Jimenez. (2014) Selective protein kinase Cθ (PKCθ) inhibitors for the treatment of autoimmune diseases. Biochemical Society Transactions 42:6, pages 1524-1528.
Crossref
Hidehiko Fukahori, Noboru Chida, Masashi Maeda, Mamoru Tasaki, Tomoko Kawashima, Hideaki Matsuoka, Keiko Suzuki, Takeshi Ishikawa, Akira Tanaka & Yasuyuki Higashi. (2014) Effect of AS2521780, a novel PKCθ selective inhibitor, on T cell-mediated immunity. European Journal of Pharmacology 745, pages 217-222.
Crossref
Xiaoming Bai, Jie Wang, Yan Guo, Jinshun Pan, Qinyi Yang, Min Zhang, Hai Li, Li Zhang, Juan Ma, Feng Shi, Wei Shu, Yipin Wang & Jing Leng. (2014) Prostaglandin E2 stimulates β1-integrin expression in hepatocellular carcinoma through the EP1 receptor/PKC/NF-κB pathway. Scientific Reports 4:1.
Crossref
Guochun Jiang, Erica A. Mendes, Philipp Kaiser, Sumathi Sankaran-Walters, Yuyang Tang, Mariana G. Weber, Greg P. Melcher, George R. Thompson, Amilcar Tanuri, Luiz F. Pianowski, Joseph K. Wong & Satya Dandekar. (2014) Reactivation of HIV latency by a newly modified Ingenol derivative via protein kinase Cδ–NF-κB signaling. AIDS 28:11, pages 1555-1566.
Crossref
Hyun Mu Shin, Mulualem E. Tilahun, Ok Hyun Cho, Karthik Chandiran, Christina Arieta Kuksin, Shilpa Keerthivasan, Abdul H. Fauq, Todd E. Golde, Lucio Miele, Margot Thome, Barbara A. Osborne & Lisa M. Minter. (2014) NOTCH1 Can Initiate NF-κB Activation via Cytosolic Interactions with Components of the T Cell Signalosome. Frontiers in Immunology 5.
Crossref
Hongpeng Huang, Qiuqiong Tang, Hongqian Chu, Jianjun Jiang, Haizhou Zhang, Weidong Hao & Xuetao Wei. (2014) MAP4K4 deletion inhibits proliferation and activation of CD4+ T cell and promotes T regulatory cell generation in vitro. Cellular Immunology 289:1-2, pages 15-20.
Crossref
Bin Wei, Lei Han, Truus E M Abbink, Elisabetta Groppelli, Daina Lim, Youg Raj Thaker, Wei Gao, Rongrong Zhai, Jianhua Wang, Andrew Lever, Clare Jolly, Hongyan Wang & Christopher E Rudd. (2013) Immune adaptor ADAP in T cells regulates HIV-1 transcription and cell-cell viral spread via different co-receptors. Retrovirology 10:1.
Crossref
Kok-Fai Kong & Amnon Altman. (2013) In and out of the bull's eye: protein kinase Cs in the immunological synapse. Trends in Immunology 34:5, pages 234-242.
Crossref
Juan-Miguel JimenezDean BoyallGuy BrenchleyPhilip N. CollierChristopher J. DavisDamien FraysseShazia B. KeilyJaclyn HendersonAndrew MillerFrancoise PierardLuca SettimoHeather C. TwinClaire M. BoltonAdam P. CurnockPeter ChiuAdam J. TannerStephen Young. (2013) Design and Optimization of Selective Protein Kinase C θ (PKCθ) Inhibitors for the Treatment of Autoimmune Diseases. Journal of Medicinal Chemistry 56:5, pages 1799-1810.
Crossref
Lutz-Nicoladoni Christina, Thuille Nikolaus, Wachowicz Katarzyna, Gruber Thomas, Leitges Michael & Baier Gottfried. (2013) PKCα and PKCβ cooperate functionally in CD3-induced de novo IL-2 mRNA transcription. Immunology Letters 151:1-2, pages 31-38.
Crossref
Bastian Hoesel & Johannes A Schmid. (2013) The complexity of NF-κB signaling in inflammation and cancer. Molecular Cancer 12:1, pages 86.
Crossref
Elizabeth Yan Zhang, Kok-Fai Kong & Amnon Altman. 2013. Immunopharmacology. Immunopharmacology 267 312 .
Tammy T Chang, Isabelle Walther, Chai-Fei Li, Jim Boonyaratanakornkit, Grazia Galleri, Maria Antonia Meloni, Proto Pippia, Augusto Cogoli & Millie Hughes-Fulford. (2012) The Rel/NF-κB pathway and transcription of immediate early genes in T cell activation are inhibited by microgravity. Journal of Leukocyte Biology 92:6, pages 1133-1145.
Crossref
Koh Fujinaga, Matjaz Barboric, Qintong Li, Zeping Luo, David H. Price & B. Matija Peterlin. (2012) PKC phosphorylates HEXIM1 and regulates P-TEFb activity. Nucleic Acids Research 40:18, pages 9160-9170.
Crossref
Robert V. Stahelin, Kok-Fai Kong, Sumita Raha, Wen Tian, Heather R. Melowic, Katherine E. Ward, Diana Murray, Amnon Altman & Wonhwa Cho. (2012) Protein Kinase Cθ C2 Domain Is a Phosphotyrosine Binding Module That Plays a Key Role in Its Activation. Journal of Biological Chemistry 287:36, pages 30518-30528.
Crossref
Kai Wang, Liang-Hui Diao, Yu Gong, Xin Liu & Yingqiu Li. (2012) NEMO differentially regulates TCR and TNF-α induced NF-κB pathways and has an inhibitory role in TCR-induced NF-κB activation. Cellular Signalling 24:8, pages 1556-1564.
Crossref
Jian Ma, Yan Ding, Xianfeng Fang, Ruiqing Wang & Zuoming Sun. (2012) Protein Kinase C-θ Inhibits Inducible Regulatory T Cell Differentiation via an AKT-Foxo1/3a–Dependent Pathway. The Journal of Immunology 188:11, pages 5337-5347.
Crossref
Ju Kyoung Song, Mi Ran Jo, Mi Hee Park, Ho Sueb Song, Byeong Jun An, Min Jong Song, Sang Bae Han & Jin Tae Hong. (2012) Cell growth inhibition and induction of apoptosis by snake venom toxin in ovarian cancer cell via inactivation of nuclear factor κB and signal transducer and activator of transcription 3. Archives of Pharmacal Research 35:5, pages 867-876.
Crossref
Changying Jiang & Xin Lin. (2012) Regulation of NF-κB by the CARD proteins. Immunological Reviews 246:1, pages 141-153.
Crossref
Xianfeng Fang, Ruiqing Wang, Jian Ma, Yan Ding, Weirong Shang & Zuoming Sun. (2012) Ameliorated ConA-Induced Hepatitis in the Absence of PKC-theta. PLoS ONE 7:2, pages e31174.
Crossref
Paúl E. Clavijo & Kenneth A. Frauwirth. (2012) Anergic CD8+ T Lymphocytes Have Impaired NF-κB Activation with Defects in p65 Phosphorylation and Acetylation. The Journal of Immunology 188:3, pages 1213-1221.
Crossref
Ruiqing Wang, Huimin Xie, Zhaofeng Huang, Weirong Shang & Zuoming Sun. (2012) Developing and Activated T Cell Survival Depends on Differential Signaling Pathways to Regulate Anti-Apoptotic Bcl-x L . Clinical and Developmental Immunology 2012, pages 1-6.
Crossref
Kok-Fai Kong, Tadashi Yokosuka, Ann J Canonigo-Balancio, Noah Isakov, Takashi Saito & Amnon Altman. (2011) A motif in the V3 domain of the kinase PKC-θ determines its localization in the immunological synapse and functions in T cells via association with CD28. Nature Immunology 12:11, pages 1105-1112.
Crossref
Sukanya Phalitakul, Muneyoshi Okada, Yukio Hara & Hideyuki Yamawaki. (2011) Vaspin prevents TNF-α-induced intracellular adhesion molecule-1 via inhibiting reactive oxygen species-dependent NF-κB and PKCθ activation in cultured rat vascular smooth muscle cells. Pharmacological Research 64:5, pages 493-500.
Crossref
Alexandra Zanin-Zhorov, Michael L. Dustin & Bruce R. Blazar. (2011) PKC-θ function at the immunological synapse: prospects for therapeutic targeting. Trends in Immunology 32:8, pages 358-363.
Crossref
Jing Cheng, Angela Montecalvo & Lawrence P. Kane. (2011) Regulation of NF-κB induction by TCR/CD28. Immunologic Research 50:2-3, pages 113-117.
Crossref
Alessandro Barbarulo, Paola Grazioli, Antonio F. Campese, Diana Bellavia, Giuseppina Di Mario, Maria Pelullo, Ambra Ciuffetta, Sara Colantoni, Alessandra Vacca, Luigi Frati, Alberto Gulino, Maria Pia Felli & Isabella Screpanti. (2011) Notch3 and Canonical NF-κB Signaling Pathways Cooperatively Regulate Foxp3 Transcription. The Journal of Immunology 186:11, pages 6199-6206.
Crossref
Loretta Tuosto. (2011) NF-κB family of transcription factors: Biochemical players of CD28 co-stimulation. Immunology Letters 135:1-2, pages 1-9.
Crossref
Keunwook Lee, Prathyusha Gudapati, Srdjan Dragovic, Charles Spencer, Sebastian Joyce, Nigel Killeen, Mark A. Magnuson & Mark Boothby. (2010) Mammalian Target of Rapamycin Protein Complex 2 Regulates Differentiation of Th1 and Th2 Cell Subsets via Distinct Signaling Pathways. Immunity 32:6, pages 743-753.
Crossref
Jung Ok Ban, Ju Hoon Oh, Bang Yeon Hwang, Dong Cheul Moon, Heon-Sang Jeong, Seram Lee, Soyoun Kim, Hyosung Lee, Kyung-Bo Kim, Sang Bae Han & Jin Tae Hong. (2009) Inflexinol inhibits colon cancer cell growth through inhibition of nuclear factor-κB activity via direct interaction with p50. Molecular Cancer Therapeutics 8:6, pages 1613-1624.
Crossref
Vincent Kam Wai Wong, Hua Zhou, Simon Shiu Fai Cheung, Ting Li & Liang Liu. (2009) Mechanistic study of saikosaponin-d (Ssd) on suppression of murine T lymphocyte activation. Journal of Cellular Biochemistry 107:2, pages 303-315.
Crossref
XueSong Huang, Ling-Yu Chen, Astrid M. Doerner, Warren W. Pan, Laura Smith, Shuang Huang, Thomas J. Papadimos & Zhixing K. Pan. (2009) An Atypical Protein Kinase C (PKCζ) Plays a Critical Role in Lipopolysaccharide-Activated NF-κB in Human Peripheral Blood Monocytes and Macrophages. The Journal of Immunology 182:9, pages 5810-5815.
Crossref
Hélène Bour-Jordan & Jeffrey A. Bluestone. (2009) Regulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells. Immunological Reviews 229:1, pages 41-66.
Crossref
M.J. O’Shaughnessy, C. Vogtenhuber, K. Sun, R. Sitcheran, A.S. Baldwin, W.J. Murphy, L. Dang, B. Jaffee, E. Palmer, J.S. Serody & B.R. Blazar. (2009) Ex vivo Inhibition of NF-κB Signaling in Alloreactive T-cells Prevents Graft-Versus-Host Disease. American Journal of Transplantation 9:3, pages 452-462.
Crossref
Marzenna Blonska & Xin Lin. (2009) CARMA1-mediated NF-κB and JNK activation in lymphocytes. Immunological Reviews 228:1, pages 199-211.
Crossref
Javier Briones, Esther Moga, Iñigo Espinosa, Carmen Vergara, Eva Alvarez, Juliana Villa, Ramón Bordes, Julio Delgado, Jaime Prat & Jorge Sierra. (2009) Bcl-10 protein highly correlates with the expression of phosphorylated p65 NF-κB in peripheral T-cell lymphomas and is associated with clinical outcome. Histopathology 54:4, pages 478-485.
Crossref
Jiannan Huang, Tong Ren, Hui Guan, Yixing Jiang & Hua Cheng. (2009) HTLV-1 Tax Is a Critical Lipid Raft Modulator That Hijacks IκB Kinases to the Microdomains for Persistent Activation of NF-κB. Journal of Biological Chemistry 284:10, pages 6208-6217.
Crossref
Lei Wang, Zhidan Xiang, Lian-Li Ma, Zhongyi Chen, Xiudan Gao, Zuoming Sun, Phillip Williams, Ravi S. Chari & Deng-Ping Yin. (2009) Deficiency of Protein Kinase C-Theta Facilitates Tolerance Induction. Transplantation 87:4, pages 507-516.
Crossref
Sonal Gupta, Santhakumar Manicassamy, Chenthamarakshan Vasu, Anvita Kumar, Weirong Shang & Zuoming Sun. (2008) Differential requirement of PKC-θ in the development and function of natural regulatory T cells. Molecular Immunology 46:2, pages 213-224.
Crossref
Prescilla V. Jeurink, Yvonne M. Vissers, Bianca Rappard & Huub F.J. Savelkoul. (2008) T cell responses in fresh and cryopreserved peripheral blood mononuclear cells: Kinetics of cell viability, cellular subsets, proliferation, and cytokine production. Cryobiology 57:2, pages 91-103.
Crossref
Santhakumar Manicassamy, Dengping Yin, Zheng Zhang, Luciana L. Molinero, Marisa-Luisa Alegre & Zuoming Sun. (2008) A Critical Role for Protein Kinase C-θ-Mediated T Cell Survival in Cardiac Allograft Rejection. The Journal of Immunology 181:1, pages 513-520.
Crossref
Johan Garaude, Sandra Kaminski, Seyma Charni, Juan Ignacio Aguilò, Chantal Jacquet, Marc Plays, Javier Hernandez, Fernando Rodriguez, Robert A. Hipskind, Alberto Anel & Martin Villalba. (2008) Impaired anti-leukemic immune response in PKCθ-deficient mice. Molecular Immunology 45:12, pages 3463-3469.
Crossref
Britt Mellström, Magali Savignac, Rosa Gomez-Villafuertes & Jose R. Naranjo. (2008) Ca 2+ -Operated Transcriptional Networks: Molecular Mechanisms and In Vivo Models . Physiological Reviews 88:2, pages 421-449.
Crossref
Isabel María OlazabalNoa Beatriz Martín-CofrecesMaría Mittelbrunn, Gloria Martínez del Hoyo, Balbino Alarcón & Francisco Sánchez-Madrid. (2008) Activation Outcomes Induced in Naïve CD8 T-Cells by Macrophages Primed via “Phagocytic” and Nonphagocytic Pathways. Molecular Biology of the Cell 19:2, pages 701-710.
Crossref
Thomas Gruber, Friedrich Fresser, Marcel Jenny, Florian Überall, Michael Leitges & Gottfried Baier. (2008) PKCθ cooperates with atypical PKCζ and PKCι in NF-κB transactivation of T lymphocytes. Molecular Immunology 45:1, pages 117-126.
Crossref
Karine Belguise & Gail E. Sonenshein. (2007) PKCθ promotes c-Rel–driven mammary tumorigenesis in mice and humans by repressing estrogen receptor α synthesis. Journal of Clinical Investigation.
Crossref
Rosa M. Aspalter, Martha M. Eibl & Hermann M. Wolf. (2007) Defective T-cell activation caused by impairment of the TNF receptor 2 costimulatory pathway in common variable immunodeficiency. Journal of Allergy and Clinical Immunology 120:5, pages 1193-1200.
Crossref
Samuel D. Saibil, Russell G. Jones, Elissa K. Deenick, Nicole Liadis, Alisha R. Elford, Mitchell G. Vainberg, Heather Baerg, James R. Woodgett, Steve Gerondakis & Pamela S. Ohashi. (2007) CD4+ and CD8+ T Cell Survival Is Regulated Differentially by Protein Kinase Cθ, c-Rel, and Protein Kinase B. The Journal of Immunology 178:5, pages 2932-2939.
Crossref
Miho Kubo-Murai, Kaoru Hazeki, Naoe Sukenobu, Kyoko Yoshikawa, Kiyomi Nigorikawa, Kazumi Inoue, Toshiyoshi Yamamoto, Misako Matsumoto, Tsukasa Seya, Norimitsu Inoue & Osamu Hazeki. (2007) Protein kinase Cδ binds TIRAP/Mal to participate in TLR signaling. Molecular Immunology 44:9, pages 2257-2264.
Crossref
Dong Ju Son, Mi Hee Park, Sang Jin Chae, Soon Ok Moon, Jae Woong Lee, Ho Sueb Song, Dong Cheul Moon, Sang Sun Kang, Young Ee Kwon & Jin Tae Hong. (2007) Inhibitory effect of snake venom toxin from Vipera lebetina turanica on hormone-refractory human prostate cancer cell growth: induction of apoptosis through inactivation of nuclear factor κB . Molecular Cancer Therapeutics 6:2, pages 675-683.
Crossref
Cécile Springael, Séverine Thomas, Souad Rahmouni, Arnaud Vandamme, Michel Goldman, Fabienne Willems & Olivier Vosters. (2007) Rottlerin inhibits human T cell responses. Biochemical Pharmacology 73:4, pages 515-525.
Crossref
Santhakumar Manicassamy & Zuoming Sun. (2007) The Critical Role of Protein Kinase C-θ in Fas/Fas Ligand-Mediated Apoptosis. The Journal of Immunology 178:1, pages 312-319.
Crossref
Jan Schulze-Luehrmann & Sankar Ghosh. (2006) Antigen-Receptor Signaling to Nuclear Factor κB. Immunity 25:5, pages 701-715.
Crossref
Wayne G. Fisher, Pei-Chi Yang, Ram K. Medikonduri & M. Saleet Jafri. (2006) NFAT and NFκB Activation in T Lymphocytes: A Model of Differential Activation of Gene Expression. Annals of Biomedical Engineering 34:11, pages 1712-1728.
Crossref
M S Hayden, A P West & S Ghosh. (2006) NF-κB and the immune response. Oncogene 25:51, pages 6758-6780.
Crossref
Keitaro Hayashi & Amnon Altman. (2006) Filamin A Is Required for T Cell Activation Mediated by Protein Kinase C-θ. The Journal of Immunology 177:3, pages 1721-1728.
Crossref
Ryosuke Watanabe, Yohsuke Harada, Kei Takeda, Jun Takahashi, Kazunobu Ohnuki, Shuhei Ogawa, Daisuke Ohgai, Nanako Kaibara, Osamu Koiwai, Kazunari Tanabe, Hiroshi Toma, Kazuo Sugamura & Ryo Abe. (2006) Grb2 and Gads Exhibit Different Interactions with CD28 and Play Distinct Roles in CD28-Mediated Costimulation. The Journal of Immunology 177:2, pages 1085-1091.
Crossref
Santhakumar Manicassamy, Sonal Gupta, Zhaofeng Huang & Zuoming Sun. (2006) Protein Kinase C-θ-Mediated Signals Enhance CD4+ T Cell Survival by Up-Regulating Bcl-xL. The Journal of Immunology 176:11, pages 6709-6716.
Crossref
R Weil & A Israël. (2006) Deciphering the pathway from the TCR to NF-κB. Cell Death & Differentiation 13:5, pages 826-833.
Crossref
Seng-Lai Tan, Jingyong Zhao, Chen Bi, XinYi Cynthia Chen, Deena L. Hepburn, Jian Wang, Jonathon D. Sedgwick, Subba R. Chintalacharuvu & Songqing Na. (2006) Resistance to Experimental Autoimmune Encephalomyelitis and Impaired IL-17 Production in Protein Kinase Cθ-Deficient Mice. The Journal of Immunology 176:5, pages 2872-2879.
Crossref
Santhakumar Manicassamy, Maureen Sadim, Richard D. Ye & Zuoming Sun. (2006) Differential Roles of PKC-θ in the Regulation of Intracellular Calcium Concentration in Primary T Cells. Journal of Molecular Biology 355:3, pages 347-359.
Crossref
Rina Barouch-Bentov & Amnon Altman. 2006. Lymphocyte Signal Transduction. Lymphocyte Signal Transduction 1 13 .
Zhi-Wei Li & Michael Karin. 2006. NF-κB/Rel Transcription Factor Family. NF-κB/Rel Transcription Factor Family 12 25 .
Dirk Brenner, Alexander Golks, Friedemann Kiefer, Peter H Krammer & Rüdiger Arnold. (2005) Activation or suppression of NFκB by HPK1 determines sensitivity to activation-induced cell death. The EMBO Journal 24:24, pages 4279-4290.
Crossref
Paola Contini, Massimo Ghio, Andrea Merlo, Alessandro Poggi, Francesco Indiveri & Francesco Puppo. (2005) Apoptosis of Antigen-Specific T Lymphocytes upon the Engagement of CD8 by Soluble HLA Class I Molecules Is Fas Ligand/Fas Mediated: Evidence for the Involvement of p56 lck , Calcium Calmodulin Kinase II, and Calcium-Independent Protein Kinase C Signaling Pathways and for NF-κB and NF-AT Nuclear Translocation . The Journal of Immunology 175:11, pages 7244-7254.
Crossref
Reiko Matsumoto, Donghai Wang, Marzenna Blonska, Hongxiu Li, Masayuki Kobayashi, Bhanu Pappu, Yuhong Chen, Demin Wang & Xin Lin. (2005) Phosphorylation of CARMA1 Plays a Critical Role in T Cell Receptor-Mediated NF-κB Activation. Immunity 23:6, pages 575-585.
Crossref
Karen Sommer, Beichu Guo, Joel L. Pomerantz, Ashok D. Bandaranayake, Miguel E. Moreno-García, Yulia L. Ovechkina & David J. Rawlings. (2005) Phosphorylation of the CARMA1 Linker Controls NF-κB Activation. Immunity 23:6, pages 561-574.
Crossref
Chung Yee Leung, Liang Liu, Ricky N.S. Wong, Yao Ying Zeng, Ming Li & Hua Zhou. (2005) Saikosaponin-d inhibits T cell activation through the modulation of PKCθ, JNK, and NF-κB transcription factor. Biochemical and Biophysical Research Communications 338:4, pages 1920-1927.
Crossref
Ryosuke Inoue, Nori-aki Matsuki, Gao Jing, Takashi Kanematsu, Kihachiro Abe & Masato Hirata. (2005) The inhibitory effect of alendronate, a nitrogen-containing bisphosphonate on the PI3K-Akt-NF κ B pathway in osteosarcoma cells . British Journal of Pharmacology 146:5, pages 633-641.
Crossref
Asim K. Mandal, Rabindranath Ray, Zhongjian Zhang, Bhabadeb Chowdhury, Nagarajan Pattabiraman & Anil B. Mukherjee. (2005) Uteroglobin Inhibits Prostaglandin F2α Receptor-mediated Expression of Genes Critical for the Production of Pro-inflammatory Lipid Mediators. Journal of Biological Chemistry 280:38, pages 32897-32904.
Crossref
Sergey A. Trushin, Gary D. Bren, Susana Asin, Kevin N. Pennington, Carlos V. Paya & Andrew D. Badley. (2005) Human Immunodeficiency Virus Reactivation by Phorbol Esters or T-Cell Receptor Ligation Requires both PKCα and PKCθ. Journal of Virology 79:15, pages 9821-9830.
Crossref
Soo Ok Lee, Wei Lou, Nagalakshmi Nadiminty, Xin Lin & Allen C. Gao. (2005) Requirement for NF-κB in interleukin-4-induced androgen receptor activation in prostate cancer cells. The Prostate 64:2, pages 160-167.
Crossref
Hui-Chen Hsu, Donald K. Scott & John D. Mountz. (2005) Impaired apoptosis and immune senescence - cause or effect?. Immunological Reviews 205:1, pages 130-146.
Crossref
Ling-Yu Chen, Astrid Doerner, Paul F. Lehmann, Shuang Huang, Guangming Zhong & Zhixing K. Pan. (2005) A Novel Protein Kinase C (PKCϵ) Is Required for fMet-Leu-Phe-induced Activation of NF-κB in Human Peripheral Blood Monocytes. Journal of Biological Chemistry 280:23, pages 22497-22501.
Crossref
Ki-Young LeeFulvio D'AcquistoMatthew S. HaydenJae-Hyuck ShimSankar Ghosh. (2005) PDK1 Nucleates T Cell Receptor-Induced Signaling Complex for NF-κB Activation. Science 308:5718, pages 114-118.
Crossref
Helen SuNicolas BidèreLixin ZhengAlan CubreKeiko SakaiJanet DaleLeonardo SalmenaRazqallah HakemStephen StrausMichael Lenardo. (2005) Requirement for Caspase-8 in NF-κB Activation by Antigen Receptor. Science 307:5714, pages 1465-1468.
Crossref
Maria Pia Felli, Alessandra Vacca, Angelica Calce, Diana Bellavia, Antonio F Campese, Rita Grillo, Monica Di Giovine, Saula Checquolo, Claudio Talora, Rocco Palermo, Giuseppina Di Mario, Luigi Frati, Alberto Gulino & Isabella Screpanti. (2004) PKCθ mediates pre-TCR signaling and contributes to Notch3-induced T-cell leukemia. Oncogene 24:6, pages 992-1000.
Crossref
Yingqiu Li, Caitlin E. Sedwick, Junru Hu & Amnon Altman. (2005) Role for Protein Kinase Cθ (PKCθ) in TCR/CD28-mediated Signaling through the Canonical but Not the Non-canonical Pathway for NF-κB Activation. Journal of Biological Chemistry 280:2, pages 1217-1223.
Crossref
Mark F. McCarty. (2005) Potential utility of natural polyphenols for reversing fat-induced insulin resistance. Medical Hypotheses 64:3, pages 628-635.
Crossref
Alison M. Michie & Rinako Nakagawa. (2005) The link between PKCα regulation and cellular transformation. Immunology Letters 96:2, pages 155-162.
Crossref
Xin Lin & Demin Wang. (2004) The roles of CARMA1, Bcl10, and MALT1 in antigen receptor signaling. Seminars in Immunology 16:6, pages 429-435.
Crossref
Shahram Salek-Ardakani, Takanori So, Beth S. Halteman, Amnon Altman & Michael Croft. (2004) Differential Regulation of Th2 and Th1 Lung Inflammatory Responses by Protein Kinase Cθ. The Journal of Immunology 173:10, pages 6440-6447.
Crossref
Samuel A. Williams, Lin-Feng Chen, Hakju Kwon, David Fenard, Dwayne Bisgrove, Eric Verdin & Warner C. Greene. (2004) Prostratin Antagonizes HIV Latency by Activating NF-κB. Journal of Biological Chemistry 279:40, pages 42008-42017.
Crossref
Marjan Hezareh, Moulay Ahmed Moukil, Ildiko Szanto, Malgorzata Pondarzewski, Sarah Mouche, Nathalie Cherix, Stephen J Brown, Jean-Louis Carpentier & Michelangelo Foti. (2016) Mechanisms of HIV Receptor and Co-Receptor Down-Regulation by Prostratin: Role of Conventional and Novel PKC Isoforms. Antiviral Chemistry and Chemotherapy 15:4, pages 207-222.
Crossref
Romania Stilo, Domenico Liguoro, Bruno Di Jeso, Silvestro Formisano, Eduardo Consiglio, Antonio Leonardi & Pasquale Vito. (2004) Physical and Functional Interaction of CARMA1 and CARMA3 with Iκ Kinase γ-NFκB Essential Modulator. Journal of Biological Chemistry 279:33, pages 34323-34331.
Crossref
Bruce Beutler. (2004) Inferences, questions and possibilities in Toll-like receptor signalling. Nature 430:6996, pages 257-263.
Crossref
James P. O'Keefe, Kelly Blaine, Maria-Luisa Alegre & Thomas F. Gajewski. (2004) Formation of a central supramolecular activation cluster is not required for activation of naive CD8 + T cells . Proceedings of the National Academy of Sciences 101:25, pages 9351-9356.
Crossref
Beichu Guo, Thomas T Su & David J Rawlings. (2004) Protein kinase C family functions in B-cell activation. Current Opinion in Immunology 16:3, pages 367-373.
Crossref
Robert Weil & Alain Israël. (2004) T-cell-receptor- and B-cell-receptor-mediated activation of NF-κB in lymphocytes. Current Opinion in Immunology 16:3, pages 374-381.
Crossref
Lijun Sun, Li Deng, Chee-Kwee Ea, Zong-Ping Xia & Zhijian J. Chen. (2004) The TRAF6 Ubiquitin Ligase and TAK1 Kinase Mediate IKK Activation by BCL10 and MALT1 in T Lymphocytes. Molecular Cell 14:3, pages 289-301.
Crossref
Matthew C. Catley, Lisa M. Cambridge, Yasuyuki Nasuhara, Kazuhiro Ito, Joanna E. Chivers, Andrew Beaton, Neil S. Holden, Martin W. Bergmann, Peter J. Barnes & Robert Newton. (2004) Inhibitors of Protein Kinase C (PKC) Prevent Activated Transcription. Journal of Biological Chemistry 279:18, pages 18457-18466.
Crossref
Tuanjie Che, Yun You, Donghai Wang, Matthew J. Tanner, Vishva M. Dixit & Xin Lin. (2004) MALT1/Paracaspase Is a Signaling Component Downstream of CARMA1 and Mediates T Cell Receptor-induced NF-κB Activation. Journal of Biological Chemistry 279:16, pages 15870-15876.
Crossref
Nancy N. Berg-Brown, Matthew A. Gronski, Russell G. Jones, Alisha R. Elford, Elissa K. Deenick, Bernhard Odermatt, Dan R. Littman & Pamela S. Ohashi. (2004) PKCθ Signals Activation versus Tolerance In Vivo. Journal of Experimental Medicine 199:6, pages 743-752.
Crossref
Peter C. Lucas, Linda M. McAllister-Lucas & Gabriel Nuñez. (2004) NF-κB signaling in lymphocytes: a new cast of characters. Journal of Cell Science 117:1, pages 31-39.
Crossref
Jason A. Gustin, Osman N. Ozes, Hakan Akca, Roxana Pincheira, Lindsey D. Mayo, Qiutang Li, Javier Rivera Guzman, Chandrashekhar K. Korgaonkar & David B. Donner. (2004) Cell Type-specific Expression of the IκB Kinases Determines the Significance of Phosphatidylinositol 3-Kinase/Akt Signaling to NF-κB Activation. Journal of Biological Chemistry 279:3, pages 1615-1620.
Crossref
M. Lienhard Schmitz, Susanne Bacher & Oliver Dienz. (2003) NF‐ĸB activation pathways induced by T cell costimulation. The FASEB Journal 17:15, pages 2187-2193.
Crossref
M S Robles, E Leonardo, L M Criado, M Izquierdo & C Martínez-A. (2003) Exacerbated inflammatory responses in transgenic mice expressing an inhibitor of apoptosis protein (OpIAP). Cell Death & Differentiation 10:11, pages 1226-1233.
Crossref
ChengFeng Yang & Marcelo G Kazanietz. (2003) Divergence and complexities in DAG signaling: looking beyond PKC. Trends in Pharmacological Sciences 24:11, pages 602-608.
Crossref
Mohammad Ishaq, Gerald DeGray & Ven Natarajan. (2003) Protein Kinase Cθ Modulates Nuclear Receptor-Corepressor Interaction during T Cell Activation. Journal of Biological Chemistry 278:41, pages 39296-39302.
Crossref
Ernesto Díaz-Flores, María Siliceo, Carlos Martínez-A.Isabel Mérida. (2003) Membrane Translocation of Protein Kinase Cθ during T Lymphocyte Activation Requires Phospholipase C-γ-generated Diacylglycerol. Journal of Biological Chemistry 278:31, pages 29208-29215.
Crossref
Christopher E. Rudd & Helga Schneider. (2003) Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling. Nature Reviews Immunology 3:7, pages 544-556.
Crossref
Christa Pfeifhofer, Kurt Kofler, Thomas Gruber, Nassim Ghaffari Tabrizi, Christina Lutz, Karl Maly, Michael Leitges & Gottfried Baier. (2003) Protein Kinase C θ Affects Ca2+ Mobilization and NFAT Activation in Primary Mouse T Cells. Journal of Experimental Medicine 197:11, pages 1525-1535.
Crossref
Jürgen Ruland & Tak W. Mak. (2003) Transducing signals from antigen receptors to nuclear factor κB. Immunological Reviews 193:1, pages 93-100.
Crossref
Hiromitsu Hara, Teiji Wada, Chris Bakal, Ivona Kozieradzki, Shinobu Suzuki, Nobutaka Suzuki, Mai Nghiem, Emily K Griffiths, Connie Krawczyk, Birgit Bauer, Fulvio D'Acquisto, Sankar Ghosh, Wen-Chen Yeh, Gottfried Baier, Robert Rottapel & Josef M Penninger. (2003) The MAGUK Family Protein CARD11 Is Essential for Lymphocyte Activation. Immunity 18:6, pages 763-775.
Crossref
Toru Koike, Hiroko Yamagishi, Yasue Hatanaka, Atsuki Fukushima, Jing-wen Chang, Yan Xia, Mark Fields, Phillip Chandler & Makio Iwashima. (2003) A Novel ERK-dependent Signaling Process That Regulates Interleukin-2 Expression in a Late Phase of T Cell Activation. Journal of Biological Chemistry 278:18, pages 15685-15692.
Crossref
Birgit Bauer, Marcel Jenny, Fiedrich Fresser, Florian Überall & Gottfried Baier. (2003) AKT1/PKBα is recruited to lipid rafts and activated downstream of PKC isotypes in CD3-induced T cell signaling. FEBS Letters 541:1-3, pages 155-162.
Crossref
Andrew D. Wells, Qing-Hua Liu, Brian Hondowicz, Jidong Zhang, Laurence A. Turka & Bruce D. Freedman. (2003) Regulation of T Cell Activation and Tolerance by Phospholipase Cγ-1-Dependent Integrin Avidity Modulation. The Journal of Immunology 170:8, pages 4127-4133.
Crossref
Amnon Altman & Martin Villalba. (2003) Protein kinase C-θ (PKCθ): it's all about location, location, location. Immunological Reviews 192:1, pages 53-63.
Crossref
Gottfried Baier. (2003) The PKC gene module: molecular biosystematics to resolve its T cell functions. Immunological Reviews 192:1, pages 64-79.
Crossref
Maria-Cristina Seminario & Ronald L. Wange. (2003) Lipid phosphatases in the regulation of T cell activation: living up to their PTEN-tial. Immunological Reviews 192:1, pages 80-97.
Crossref
Stefan Heinrichs & Wolfgang Deppert. (2003) Apoptosis or growth arrest: modulation of the cellular response to p53 by proliferative signals. Oncogene 22:4, pages 555-571.
Crossref
Guoqiang Jiang, Qing Dallas-Yang, Franklin Liu, David E. Moller & Bei B. Zhang. (2003) Salicylic Acid Reverses Phorbol 12-Myristate-13-Acetate (PMA)- and Tumor Necrosis Factor α (TNFα)-induced Insulin Receptor Substrate 1 (IRS1) Serine 307 Phosphorylation and Insulin Resistance in Human Embryonic Kidney 293 (HEK293) Cells. Journal of Biological Chemistry 278:1, pages 180-186.
Crossref
J.-L. Poyet & E. S. Alnemri. 2003. Nuclear Factor кB. Nuclear Factor кB 69 88 .
O. Dienz, S. Bacher & M. L. Schmitz. 2003. Nuclear Factor кB. Nuclear Factor кB 353 371 .
Hiroaki Niiro & Edward A. Clark. (2002) Regulation of B-cell fate by antigen-receptor signals. Nature Reviews Immunology 2:12, pages 945-956.
Crossref
Barbara Cipriani, Heather Knowles, Lanfen Chen, Luca Battistini & Celia F. Brosnan. (2002) Involvement of Classical and Novel Protein Kinase C Isoforms in the Response of Human Vγ9Vδ2 T Cells to Phosphate Antigens. The Journal of Immunology 169:10, pages 5761-5770.
Crossref
Donghai Wang, Yun You, Sara M. Case, Linda M. McAllister-Lucas, Lin Wang, Peter S. DiStefano, Gabriel Nuñez, John Bertin & Xin Lin. (2002) A requirement for CARMA1 in TCR-induced NF-κB activation. Nature Immunology 3:9, pages 830-835.
Crossref
Mitsuru Matsumoto, Takuji Yamada, Steven K. Yoshinaga, Tom Boone, Tom Horan, Shigeru Fujita, Yi Li & Tasuku Mitani. (2002) Essential Role of NF-κB-Inducing Kinase in T Cell Activation Through the TCR/CD3 Pathway. The Journal of Immunology 169:3, pages 1151-1158.
Crossref
Lawrence P. Kane, Joseph Lin & Arthur Weiss. (2002) It's all Rel-ative: NF-κB and CD28 costimulation of T-cell activation. Trends in Immunology 23:8, pages 413-420.
Crossref
Mohammad Ishaq, Ming Fan, Kip Wigmore, Arunasri Gaddam & Ven Natarajan. (2002) Regulation of Retinoid X Receptor Responsive Element-Dependent Transcription in T Lymphocytes by Ser/Thr Phosphatases: Functional Divergence of Protein Kinase C (PKC)θ and PKCα in Mediating Calcineurin-Induced Transactivation. The Journal of Immunology 169:2, pages 732-738.
Crossref
Martin Turner & Daniel D. Billadeau. (2002) VAV proteins as signal integrators for multi-subunit immune-recognition receptors. Nature Reviews Immunology 2:7, pages 476-486.
Crossref
A Garg & BB Aggarwal. (2002) Nuclear transcription factor-κB as a target for cancer drug development. Leukemia 16:6, pages 1053-1068.
Crossref
Christopher W Arendt, Björn Albrecht, Timothy J Soos & Dan R Littman. (2002) Protein kinase C-θ: signaling from the center of the T-cell synapse. Current Opinion in Immunology 14:3, pages 323-330.
Crossref
Birgit Bauer & Gottfried Baier. (2002) Protein kinase C and AKT/protein kinase B in CD4+ T-lymphocytes: new partners in TCR/CD28 signal integration. Molecular Immunology 38:15, pages 1087-1099.
Crossref
Janet Kalesnikoff, Nicole Baur, Michael Leitges, Michael R. Hughes, Jacqueline E. Damen, Michael Huber & Gerald Krystal. (2002) SHIP Negatively Regulates IgE + Antigen-Induced IL-6 Production in Mast Cells by Inhibiting NF-κB Activity. The Journal of Immunology 168:9, pages 4737-4746.
Crossref
Andre E. Nel. (2002) T-cell activation through the antigen receptor. Part 1: Signaling components, signaling pathways, and signal integration at the T-cell antigen receptor synapse. Journal of Allergy and Clinical Immunology 109:5, pages 758-770.
Crossref
Hong Ren, Aurelia Schmalstieg, Nicolai S. C. van Oers & Richard B. Gaynor. (2002) I-κB Kinases α and β Have Distinct Roles in Regulating Murine T Cell Function. The Journal of Immunology 168:8, pages 3721-3731.
Crossref
Martin Villalba, Kun Bi, Junru Hu, Yoav Altman, Paul Bushway, Eric Reits, Jacques Neefjes, Gottfried Baier, Robert T. Abraham & Amnon Altman. (2002) Translocation of PKCθ in T cells is mediated by a nonconventional, PI3-K– and Vav-dependent pathway, but does not absolutely require phospholipase C. Journal of Cell Biology 157:2, pages 253-263.
Crossref
Noah IsakovAmnon Altman. (2002) Protein Kinase Cθ in T Cell Activation. Annual Review of Immunology 20:1, pages 761-794.
Crossref
Andreas Pahl, Meixia Zhang, Hildegard Kuss, Istvan Szelenyi & Kay Brune. (2002) Regulation of IL-13 synthesis in human lymphocytes: implications for asthma therapy. British Journal of Pharmacology 135:8, pages 1915-1926.
Crossref
Jesang Ko, In Sik Kim, Sung-Wuk Jang, Young Han Lee, Soon Young Shin, Do Sik Min & Doe Sun Na. (2002) Leukotactin-1/CCL15-induced chemotaxis signaling through CCR1 in HOS cells. FEBS Letters 515:1-3, pages 159-164.
Crossref
Yuang-Taung Juang, Elena E. Solomou, Barbara Rellahan & George C. Tsokos. (2002) Phosphorylation and O -Linked Glycosylation of Elf-1 Leads to Its Translocation to the Nucleus and Binding to the Promoter of the TCR ζ-Chain . The Journal of Immunology 168:6, pages 2865-2871.
Crossref
Haruo HanawaYong MaSebastian A. MikolajczakMatthew L. CharlesTetsuya YoshidaRyoko YoshidaCraig A. StrathdeeDavid W. LitchfieldAtsuo Ochi. (2002) A novel costimulatory signaling in human T lymphocytes by a splice variant of CD28. Blood 99:6, pages 2138-2145.
Crossref
María S. Robles, Esther Leonardo, Luis Miguel Criado, Manuel Izquierdo & Carlos Martínez-A.. (2002) Inhibitor of Apoptosis Protein from Orgyia pseudotsugata Nuclear Polyhedrosis Virus Provides a Costimulatory Signal Required for Optimal Proliferation of Developing Thymocytes . The Journal of Immunology 168:4, pages 1770-1779.
Crossref
Jeffrey A. Schrager, Violette Der Minassian & Jon W. Marsh. (2002) HIV Nef Increases T Cell ERK MAP Kinase Activity. Journal of Biological Chemistry 277:8, pages 6137-6142.
Crossref
Barbara Marinari, Antonio Costanzo, Antonella Viola, Frederique Michel, Giorgio Mangino, Oreste Acuto, Massimo Levrero, Enza Piccolella & Loretta Tuosto. (2002) Vav cooperates with CD28 to induce NF-κB activation via a pathway involving Rac-1 and mitogen-activated kinase kinase 1. European Journal of Immunology 32:2, pages 447-456.
Crossref
Stephen G. Ward. 2002. Wiley Encyclopedia of Molecular Medicine. Wiley Encyclopedia of Molecular Medicine.
Yoshihiko Tanaka & Amnon Altman. (2002) T cell signaling: Protein kinase Cθ the immunological synapse and characterization of SLAT a novel T helper 2-specific adapter protein. Allergology International 51:3, pages 167-174.
Crossref
Martin Villalba, Kun Bi, Fernando Rodriguez, Yoshihiko Tanaka, Stephen Schoenberger & Amnon Altman. (2001) Vav1/Rac-dependent actin cytoskeleton reorganization is required for lipid raft clustering in T cells. Journal of Cell Biology 155:3, pages 331-338.
Crossref
Linda M. McAllister-Lucas, Naohiro Inohara, Peter C. Lucas, Jürgen Ruland, Adalberto Benito, Qiutang Li, Shu Chen, Felicia F. Chen, Shoji Yamaoka, Inder M. Verma, Tak W. Mak & Gabriel Núñez. (2001) Bimp1, a MAGUK Family Member Linking Protein Kinase C Activation to Bcl10-mediated NF-κB Induction. Journal of Biological Chemistry 276:33, pages 30589-30597.
Crossref
Birgit Bauer, Nina Krumböck, Friedrich Fresser, Franz Hochholdinger, Martin Spitaler, Andreas Simm, Florian Überall, Burkhart Schraven & Gottfried Baier. (2001) Complex Formation and Cooperation of Protein Kinase Cθ and Akt1/Protein Kinase Bα in the NF-κB Transactivation Cascade in Jurkat T Cells. Journal of Biological Chemistry 276:34, pages 31627-31634.
Crossref
Aideen Long, Dermot Kelleher, Sara Lynch & Yuri Volkov. (2001) Cutting Edge: Protein Kinase Cβ Expression Is Critical for Export of IL-2 from T Cells. The Journal of Immunology 167:2, pages 636-640.
Crossref
Jason A. Gustin, Tomohiko Maehama, Jack E. Dixon & David B. Donner. (2001) The PTEN Tumor Suppressor Protein Inhibits Tumor Necrosis Factor-induced Nuclear Factor κB Activity. Journal of Biological Chemistry 276:29, pages 27740-27744.
Crossref
Kun Bi, Yoshihiko Tanaka, Nolwenn Coudronniere, Katsuji Sugie, Sooji Hong, Marianne J. B. van Stipdonk & Amnon Altman. (2001) Antigen-induced translocation of PKC-θ to membrane rafts is required for T cell activation. Nature Immunology 2:6, pages 556-563.
Crossref
Martin Villalba, Paul Bushway & Amnon Altman. (2001) Protein Kinase C-θ Mediates a Selective T Cell Survival Signal Via Phosphorylation of BAD. The Journal of Immunology 166:10, pages 5955-5963.
Crossref
Elena E. Solomou, Yuang-Taung Juang & George C. Tsokos. (2001) Protein Kinase C-θ Participates in the Activation of Cyclic AMP-Responsive Element-Binding Protein and Its Subsequent Binding to the −180 Site of the IL-2 Promoter in Normal Human T Lymphocytes. The Journal of Immunology 166:9, pages 5665-5674.
Crossref
Thomas M. Herndon, Xiaochuan C. Shan, George C. Tsokos & Ronald L. Wange. (2001) ZAP-70 and SLP-76 Regulate Protein Kinase C-θ and NF-κB Activation in Response to Engagement of CD3 and CD28. The Journal of Immunology 166:9, pages 5654-5664.
Crossref
Jorge Moscat, Laura Sanz, Pilar Sanchez & Marı́a T. Diaz-Meco. (2001) Regulation and role of the atypical pkc isoforms in cell survival during tumor transformation. Advances in Enzyme Regulation 41:1, pages 99-120.
Crossref
Heidi Okamura & Anjana Rao. (2001) Transcriptional regulation in lymphocytes. Current Opinion in Cell Biology 13:2, pages 239-243.
Crossref
Kun Bi & Amnon Altman. (2001) Membrane lipid microdomains and the role of PKCθ in T cell activation. Seminars in Immunology 13:2, pages 139-146.
Crossref
Tsuneyasu Kaisho, Kiyoshi Takeda, Tohru Tsujimura, Taro Kawai, Fumiko Nomura, Nobuyuki Terada & Shizuo Akira. (2001) Iκb Kinase α Is Essential for Mature B Cell Development and Function. Journal of Experimental Medicine 193:4, pages 417-426.
Crossref
Tetsuya Yamamoto, Kazunori Yoneda, Eisaku Ueta & Tokio Osaki. (2001) The Upregulation by Peplomycin of Signal Transduction in Human Cells. Japanese Journal of Pharmacology 87:1, pages 41-50.
Crossref
Ivana Vancurova, Veronika Miskolci & Dennis Davidson. (2001) NF-κB Activation in Tumor Necrosis Factor α-stimulated Neutrophils Is Mediated by Protein Kinase Cδ. Journal of Biological Chemistry 276:23, pages 19746-19752.
Crossref
Lawrence P. Kane, Pietro G. Andres, Kimberly C. Howland, Abul K. Abbas & Arthur Weiss. (2001) Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-γ but not TH2 cytokines. Nature Immunology 2:1, pages 37-44.
Crossref
Jürgen Ruland, Gordon S Duncan, Andrew Elia, Ivan del Barco Barrantes, Linh Nguyen, Sue Plyte, Douglas G Millar, Denis Bouchard, Andrew Wakeham, Pamela S Ohashi & Tak W Mak. (2001) Bcl10 Is a Positive Regulator of Antigen Receptor–Induced Activation of NF-κ B and Neural Tube Closure. Cell 104:1, pages 33-42.
Crossref

Displaying 200 of 205 citing articles. Use the download link below to view the full list of citing articles.

Download full citations list

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.