24
Views
86
CrossRef citations to date
0
Altmetric
Transcriptional Regulation

Oligomerization of ETO Is Obligatory for Corepressor Interaction

, , , , , , , & show all
Pages 156-163 | Received 19 Apr 2000, Accepted 16 Oct 2000, Published online: 28 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Hong Nguyen, Jolene Mariotti, Diana Bareyan, Robert H Carnahan, Tracy Cooper, Christopher S Williams & Michael E Engel. (2015) Anti-MTG16 antibodies reveal MTG16 subcellular distribution and nucleocytoplasmic transport in erythroleukemia cells. Antibody Technology Journal 5, pages 27-41.
Read now
Michael E. Engel, Hong N. Nguyen, Jolene Mariotti, Aubrey Hunt & Scott W. Hiebert. (2010) Myeloid Translocation Gene 16 (MTG16) Interacts with Notch Transcription Complex Components To Integrate Notch Signaling in Hematopoietic Cell Fate Specification. Molecular and Cellular Biology 30:7, pages 1852-1863.
Read now
Chun Guo, Qiande Hu, Chunxia Yan & Jinsong Zhang. (2009) Multivalent Binding of the ETO Corepressor to E Proteins Facilitates Dual Repression Controls Targeting Chromatin and the Basal Transcription Machinery. Molecular and Cellular Biology 29:10, pages 2644-2657.
Read now
Shanru Li, Joel Weidenfeld & Edward E. Morrisey. (2004) Transcriptional and DNA Binding Activity of the Foxp1/2/4 Family Is Modulated by Heterotypic and Homotypic Protein Interactions. Molecular and Cellular Biology 24:2, pages 809-822.
Read now
Joseph M. Amann, John Nip, David K. Strom, Bart Lutterbach, Hironori Harada, Noel Lenny, James R. Downing, Shari Meyers & Scott W. Hiebert. (2001) ETO, a Target of t(8;21) in Acute Leukemia, Makes Distinct Contacts with Multiple Histone Deacetylases and Binds mSin3A through Its Oligomerization Domain. Molecular and Cellular Biology 21:19, pages 6470-6483.
Read now

Articles from other publishers (81)

Roland Windisch, Sophie Kreissig & Christian Wichmann. 2023. HDAC/HAT Function Assessment and Inhibitor Development. HDAC/HAT Function Assessment and Inhibitor Development 27 49 .
Kenichi Ishii, Matteo CorteseXubo LengMaxim N. ShokhirevKenta Asahina. (2022) A neurogenetic mechanism of experience-dependent suppression of aggression. Science Advances 8:36.
Crossref
Parveen Kumar, Vivek Verma, Dheeraj Mohania, Surbhi Gupta, Avneet K. Babbar, Bhawna Rathi, Rakesh S. Dhanda & Manisha Yadav. (2021) Leukemia associated RUNX1T1 gene reduced proliferation and invasiveness of glioblastoma cells. Journal of Cellular Biochemistry 122:11, pages 1737-1748.
Crossref
Kai Rejeski, Jesús Duque-Afonso & Michael Lübbert. (2021) AML1/ETO and its function as a regulator of gene transcription via epigenetic mechanisms. Oncogene 40:38, pages 5665-5676.
Crossref
Benedetto Daniele Giaimo, Ellen K. Gagliani, Rhett A. Kovall & Tilman Borggrefe. 2021. Notch Signaling in Embryology and Cancer. Notch Signaling in Embryology and Cancer 9 30 .
Linqing Zou, Haoming Li, Xiao Han, Jianbing Qin & Guoqi Song. (2020) Runx1t1 promotes the neuronal differentiation in rat hippocampus. Stem Cell Research & Therapy 11:1.
Crossref
Nickolas Steinauer, Chun Guo & Jinsong Zhang. (2020) The transcriptional corepressor CBFA2T3 inhibits all-trans-retinoic acid–induced myeloid gene expression and differentiation in acute myeloid leukemia. Journal of Biological Chemistry 295:27, pages 8887-8900.
Crossref
Alessandro Beghini. (2019) Core Binding Factor Leukemia: Chromatin Remodeling Moves Towards Oncogenic Transcription. Cancers 11:12, pages 1973.
Crossref
Orsola di Martino & John S. Welch. (2019) Retinoic Acid Receptors in Acute Myeloid Leukemia Therapy. Cancers 11:12, pages 1915.
Crossref
A. I. Kavaleuskaya & T. V. Ramanouskaya. (2019) Evolutionary history of the MTG gene family in vertebrates. Proceedings of the National Academy of Sciences of Belarus, Biological Series 64:4, pages 391-402.
Crossref
Emiel van der Kouwe & Philipp Staber. (2019) RUNX1-ETO: Attacking the Epigenome for Genomic Instable Leukemia. International Journal of Molecular Sciences 20:2, pages 350.
Crossref
Xuan Kang, Yun Feng, Zhixue Gan, Shiyang Zeng, Xiaobo Guo, Xirui Chen, Ye Zhang, Chen Wang, Kuinan Liu, Xuelin Chen, Xiaoxue Jiang, Shuting Song, Yabin Li, Su Chen, Feng Sun, Zhiyong Mao, Xiaomei Yang & Jianfeng Chang. (2018) NASP antagonize chromatin accessibility through maintaining histone H3K9me1 in hepatocellular carcinoma. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1864:10, pages 3438-3448.
Crossref
Koushik Ghosh, Ming Tang, Nidhi Kumari, Arijit Nandy, Subham Basu, Dheerendra Pratap Mall, Kunal Rai & Debabrata Biswas. (2018) Positive Regulation of Transcription by Human ZMYND8 through Its Association with P-TEFb Complex. Cell Reports 24:8, pages 2141-2154.e6.
Crossref
Kaiping Deng, Caifang Ren, Zifei Liu, Xiaoxiao Gao, Yixuan Fan, Guomin Zhang, Yanli Zhang, Ei-Samahy MA, Feng Wang & Peihua You. (2018) Characterization of RUNX1T1, an Adipogenesis Regulator in Ovine Preadipocyte Differentiation. International Journal of Molecular Sciences 19:5, pages 1300.
Crossref
Nickolas Steinauer, Chun Guo & Jinsong Zhang. (2017) Emerging Roles of MTG16 in Cell-Fate Control of Hematopoietic Stem Cells and Cancer. Stem Cells International 2017, pages 1-12.
Crossref
Shan Lin, James C. Mulloy & Susumu Goyama. 2017. RUNX Proteins in Development and Cancer. RUNX Proteins in Development and Cancer 151 173 .
Ping Wang, Dan Ma, Jishi Wang, Qin Fang, Rui Gao, Weibing Wu, Lu Cao, Xiuying Hu, Jiangyuan Zhao & Yan Li. (2016) INPP4B-mediated DNA repair pathway confers resistance to chemotherapy in acute myeloid leukemia. Tumor Biology 37:9, pages 12513-12523.
Crossref
Jian Li, Chun Guo, Nickolas Steinauer & Jinsong Zhang. (2016) New insights into transcriptional and leukemogenic mechanisms of AML1-ETO and E2A fusion proteins. Frontiers in Biology 11:4, pages 285-304.
Crossref
Christian Recher. (2015) INPP4B, a new player in the chemoresistance of AML. Blood 125:18, pages 2738-2739.
Crossref
Zou Linqing, Jin Guohua, Li HaomingTao XueleiQin JianbingTian Meiling. (2015) Runx1t1 Regulates the Neuronal Differentiation of Radial Glial Cells From the Rat Hippocampus. Stem Cells Translational Medicine 4:1, pages 110-116.
Crossref
Nimmi Baby, Yali Li, Eng-Ang Ling, Jia Lu & S. Thameem Dheen. (2014) Runx1t1 (Runt-Related Transcription Factor 1; Translocated to, 1) Epigenetically Regulates the Proliferation and Nitric Oxide Production of Microglia. PLoS ONE 9:2, pages e89326.
Crossref
Chien-Hung Gow, Chun Guo, David Wang, Qiande Hu & Jinsong Zhang. (2014) Differential involvement of E2A-corepressor interactions in distinct leukemogenic pathways. Nucleic Acids Research 42:1, pages 137-152.
Crossref
Yvonne Bartel, Manuel Grez & Christian Wichmann. (2013) Interference with RUNX1/ETO Leukemogenic Function by Cell-Penetrating Peptides Targeting the NHR2 Oligomerization Domain. BioMed Research International 2013, pages 1-14.
Crossref
Bin Gui, Xiao Han, Yu Zhang, Jing Liang, Dandan Wang, Chenghao Xuan, Zhipeng Yu & Yongfeng Shang. (2012) Dimerization of ZIP promotes its transcriptional repressive function and biological activity. The International Journal of Biochemistry & Cell Biology 44:6, pages 886-895.
Crossref
Ciro Mercurio, Saverio Minucci & Pier Giuseppe Pelicci. (2010) Histone deacetylases and epigenetic therapies of hematological malignancies. Pharmacological Research 62:1, pages 18-34.
Crossref
Kevin A. Link, Fu-Sheng Chou & James C. Mulloy. (2010) Core binding factor at the crossroads: Determining the fate of the HSC. Journal of Cellular Physiology 222:1, pages 50-56.
Crossref
Sangho ParkWei ChenTomasz CierpickiMarco TonelliXiongwei Cai, Nancy A. Speck & John H. Bushweller. (2009) Structure of the AML1-ETO eTAFH domain–HEB peptide complex and its contribution to AML1-ETO activity. Blood 113:15, pages 3558-3567.
Crossref
Ming YanEun-Young AhnScott W. Hiebert & Dong-Er Zhang. (2009) RUNX1/AML1 DNA-binding domain and ETO/MTG8 NHR2-dimerization domain are critical to AML1-ETO9a leukemogenesis. Blood 113:4, pages 883-886.
Crossref
Raman Kumar, Kelly M. Cheney, Ross McKirdy, Paul M. Neilsen, Renèe B. Schulz, Jaclyn Lee, Juliane Cohen, Grant W. Booker & David F. Callen. (2008) CBFA2T3-ZNF652 Corepressor Complex Regulates Transcription of the E-box Gene HEB. Journal of Biological Chemistry 283:27, pages 19026-19038.
Crossref
Oliver H. Krämer, Sylvia Müller, Marc Buchwald, Sigrid Reichardt & Thorsten Heinzel. (2007) Mechanism for ubiquitylation of the leukemia fusion proteins AML1‐ETO and PML‐RARα. The FASEB Journal 22:5, pages 1369-1379.
Crossref
Stefano Rossetti, André T Hoogeveen, Ping Liang, Cornel Stanciu, Peter van der Spek & Nicoletta Sacchi. (2007) A distinct epigenetic signature at targets of a leukemia protein. BMC Genomics 8:1.
Crossref
Luke F. Peterson, Anita Boyapati, Eun-Young Ahn, Joseph R. Biggs, Akiko Joo Okumura, Miao-Chia Lo, Ming Yan & Dong-Er Zhang. (2007) Acute myeloid leukemia with the 8q22;21q22 translocation: secondary mutational events and alternative t(8;21) transcripts. Blood 110:3, pages 799-805.
Crossref
Yufeng Wei, Shaohua Liu, Jörn Lausen, Christopher Woodrell, Seongeun Cho, Nikolaos Biris, Naohiro Kobayashi, Yu Wei, Shigeyuki Yokoyama & Milton H Werner. (2007) A TAF4-homology domain from the corepressor ETO is a docking platform for positive and negative regulators of transcription. Nature Structural & Molecular Biology 14:7, pages 653-661.
Crossref
Yizhou Liu, Wei Chen, Justin Gaudet, Matthew D. Cheney, Liya Roudaia, Tomasz Cierpicki, Rachel C. Klet, Kari Hartman, Thomas M. Laue, Nancy A. Speck & John H. Bushweller. (2007) Structural Basis for Recognition of SMRT/N-CoR by the MYND Domain and Its Contribution to AML1/ETO's Activity. Cancer Cell 11:6, pages 483-497.
Crossref
Kamaleldin E. Elagib & Adam N. Goldfarb. (2007) Oncogenic pathways of AML1-ETO in acute myeloid leukemia: Multifaceted manipulation of marrow maturation. Cancer Letters 251:2, pages 179-186.
Crossref
Anita BoyapatiMing YanLuke F. PetersonJoseph R. BiggsMichelle M. Le Beau & Dong-Er Zhang. (2006) A leukemia fusion protein attenuates the spindle checkpoint and promotes aneuploidy. Blood 109:9, pages 3963-3971.
Crossref
Donglan Li, Kislay K. Sinha, Maher A. Hay, Ciro R. Rinaldi, Yogen Saunthararajah & Giuseppina Nucifora. (2007) RUNX1-RUNX1 Homodimerization Modulates RUNX1 Activity and Function. Journal of Biological Chemistry 282:18, pages 13542-13551.
Crossref
Christian Wichmann, Linping Chen, Markus Heinrich, Daniela Baus, Edith Pfitzner, Martin Zörnig, Oliver G. Ottmann & Manuel Grez. (2007) Targeting the Oligomerization Domain of ETO Interferes with RUNX1/ETO Oncogenic Activity in t(8;21)-Positive Leukemic Cells. Cancer Research 67:5, pages 2280-2289.
Crossref
J Qiu, J Wong, D J Tweardy & S Dong. (2006) Decreased intranuclear mobility of acute myeloid leukemia 1-containing fusion proteins is accompanied by reduced mobility and compartmentalization of core binding factor β. Oncogene 25:28, pages 3982-3993.
Crossref
Fady M. Mikhail, Kislay K. Sinha, Yogen Saunthararajah & Giuseppina Nucifora. (2006) Normal and transforming functions of RUNX1: A perspective. Journal of Cellular Physiology 207:3, pages 582-593.
Crossref
Abdenour Soufi, Corinne Smith, Anthony R. Clarke, Kevin Gaston & Padma-Sheela Jayaraman. (2006) Oligomerisation of the Developmental Regulator Proline Rich Homeodomain (PRH/Hex) is Mediated by a Novel Proline-rich Dimerisation Domain. Journal of Molecular Biology 358:4, pages 943-962.
Crossref
Jeffrey M. Blumberg, Iphigenia Tzameli, Inna Astapova, Francis S. Lam, Jeffrey S. Flier & Anthony N. Hollenberg. (2006) Complex Role of the Vitamin D Receptor and Its Ligand in Adipogenesis in 3T3-L1 Cells. Journal of Biological Chemistry 281:16, pages 11205-11213.
Crossref
Kajal V. Sitwala & Jay L. Hess. (2006) Structural basis of multimer-mediated mayhem. Cancer Cell 9:4, pages 241-242.
Crossref
Yizhou Liu, Matthew D. Cheney, Justin J. Gaudet, Maksymilian Chruszcz, Stephen M. Lukasik, Daisuke Sugiyama, Jeff Lary, James Cole, Zbyszek Dauter, Wladek Minor, Nancy A. Speck & John H. Bushweller. (2006) The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity. Cancer Cell 9:4, pages 249-260.
Crossref
J Lausen, S Liu, M Fliegauf, M Lübbert & M H Werner. (2005) ELA2 is regulated by hematopoietic transcription factors, but not repressed by AML1-ETO. Oncogene 25:9, pages 1349-1357.
Crossref
Robert B. Lorsbach & James R. Downing. 2010. Childhood Leukemias. Childhood Leukemias 298 338 .
Vitalyi Senyuk, Donglan Li, Alexander Zakharov, Fady M. Mikhail & Giuseppina Nucifora. (2005) The Distal Zinc Finger Domain of AML1/MDS1/EVI1 Is an Oligomerization Domain Involved in Induction of Hematopoietic Differentiation Defects in Primary Cells In vitro . Cancer Research 65:17, pages 7603-7611.
Crossref
Wu Donghui, Yang Haitao, Xue Xiaoyu, Liang Wenxue, Miao Xiaoyu, Chen Saijuan & Pang Hai. (2005) Oligomerization study of NHR3 and NHR4 domains from ETO protein involved in t(8;21)-associated acute myeloid leukemia. Chinese Science Bulletin 50:9, pages 875-879.
Crossref
Tomoko Kozu, Tomofusa Fukuyama, Tohru Yamami, Kiwamu Akagi & Yasuhiko Kaneko. (2005) MYND-less splice variants ofAML1-MTG8 (RUNX1-CBFA2T1) are expressed in leukemia with t(8;21). Genes, Chromosomes and Cancer 43:1, pages 45-53.
Crossref
Anna Codina, James D. Love, Yun Li, Mitchell A. Lazar, David Neuhaus & John W. R. Schwabe. (2005) Structural insights into the interaction and activation of histone deacetylase 3 by nuclear receptor corepressors. Proceedings of the National Academy of Sciences 102:17, pages 6009-6014.
Crossref
Rakesh Kumar, Anupama E. Gururaj, Ratna K. Vadlamudi & Suresh K. Rayala. (2005) The Clinical Relevance of Steroid Hormone Receptor Corepressors. Clinical Cancer Research 11:8, pages 2822-2831.
Crossref
Naoko Koyano-Nakagawa & Chris Kintner. (2005) The expression and function of MTG/ETO family proteins during neurogenesis. Developmental Biology 278:1, pages 22-34.
Crossref
Sofia Rondin Lindberg, André Olsson, Ann-Maj Persson & Inge Olsson. (2005) The leukemia-associated ETO homologues are differently expressed during hematopoietic differentiation. Experimental Hematology 33:2, pages 189-198.
Crossref
Jörn Lausen, Seongeun Cho, Shaohua Liu & Milton H. Werner. (2004) The Nuclear Receptor Co-repressor (N-CoR) Utilizes Repression Domains I and III for Interaction and Co-repression with ETO. Journal of Biological Chemistry 279:47, pages 49281-49288.
Crossref
Angelia Fenaroli, Milos Vujanac, Dario De Cesare & Vincenzo Zimarino. (2004) A small-scale survey identifies selective and quantitative nucleo-cytoplasmic shuttling of a subset of CREM transcription factors. Experimental Cell Research 299:1, pages 209-226.
Crossref
Chi Wai SoMichael L. Cleary. (2004) Dimerization: a versatile switch for oncogenesis. Blood 104:4, pages 919-922.
Crossref
Stefano Rossetti, André T Hoogeveen & Nicoletta Sacchi. (2004) The MTG proteins: chromatin repression players with a passion for networking. Genomics 84:1, pages 1-9.
Crossref
Luke F Peterson & Dong-Er Zhang. (2004) The 8;21 translocation in leukemogenesis. Oncogene 23:24, pages 4255-4262.
Crossref
Bruce A Hug & Mitchell A Lazar. (2004) ETO interacting proteins. Oncogene 23:24, pages 4270-4274.
Crossref
Matthew J Bottomley. (2004) Structures of protein domains that create or recognize histone modifications. EMBO reports 5:5, pages 464-469.
Crossref
Jianxiang Wang, Min Wang & Johnson M Liu. (2004) Domains involved in ETO and human N-CoR interaction and ETO transcription repression. Leukemia Research 28:4, pages 409-414.
Crossref
Sofia Rondin Lindberg, André Olsson, Ann-Maj Persson & Inge Olsson. (2003) Interactions between the leukaemia-associated ETO homologues of nuclear repressor proteins. European Journal of Haematology 71:6, pages 439-447.
Crossref
Jay L. Grisolano, Julie O'Neal, Jennifer Cain & Michael H. Tomasson. (2003) An activated receptor tyrosine kinase, TEL/PDGFβR, cooperates with AML1/ETO to induce acute myeloid leukemia in mice. Proceedings of the National Academy of Sciences 100:16, pages 9506-9511.
Crossref
Corinna K Sonderegger, Mako Narisawa-Saito & Peter K Vogt. (2003) The C-terminal region of cellular Qin oligomerizes: correlation with oncogenic transformation and transcriptional repression. Oncogene 22:13, pages 1908-1915.
Crossref
Corinna K Sonderegger & Peter K Vogt. (2003) Binding of the corepressor TLE1 to Qin enhances Qin-mediated transformation of chicken embryo fibroblasts. Oncogene 22:12, pages 1749-1757.
Crossref
Anita Makowski, Sabrina Brzostek, Ronald N. Cohen & Anthony N. Hollenberg. (2003) Determination of Nuclear Receptor Corepressor Interactions with the Thyroid Hormone Receptor. Molecular Endocrinology 17:2, pages 273-286.
Crossref
Norio Asou. (2003) The role of a Runt domain transcription factor AML1/RUNX1 in leukemogenesis and its clinical implications. Critical Reviews in Oncology/Hematology 45:2, pages 129-150.
Crossref
James R Downing. (2003) The core-binding factor leukemias: lessons learned from murine models. Current Opinion in Genetics & Development 13:1, pages 48-54.
Crossref
J.Nathan Davis, Laura McGhee & Shari Meyers. (2003) The ETO (MTG8) gene family. Gene 303, pages 1-10.
Crossref
Ying Cao, Hui Zhao & Horst Grunz. (2002) XETOR regulates the size of the proneural domain during primary neurogenesis in Xenopus laevis. Mechanisms of Development 119:1, pages 35-44.
Crossref
André T Hoogeveen, Stefano Rossetti, Violeta Stoyanova, Joris Schonkeren, Angelia Fenaroli, Luisa Schiaffonati, Leontine van Unen & Nicoletta Sacchi. (2002) The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies. Oncogene 21:43, pages 6703-6712.
Crossref
Nancy A. Speck & D. Gary Gilliland. (2002) Core-binding factors in haematopoiesis and leukaemia. Nature Reviews Cancer 2:7, pages 502-513.
Crossref
Stefan Nagel, Lothar Hambach, Jürgen Krauter, Letitia Venturini, Olaf Heidenreich, Arnold Ganser & Gerhard Heil. (2002) Analysis of the Nuclear Distribution of the Translocation t(8;21)-Derived Fusion Protein AML1/ETO by Confocal Laser Scanning Microscopy. Journal of Hematotherapy & Stem Cell Research 11:2, pages 401-408.
Crossref
M. Urioste, A. Martı́nez-Ramı́rez, J.C. Cigudosa, M.S. Mateo, P. Martı́nez, T. Contra & J. Benı́tez. (2002) Identification of ins(8;21) with AML1/ETO fusion in acute myelogenous leukemia M2 by molecular cytogenetics. Cancer Genetics and Cytogenetics 133:1, pages 83-86.
Crossref
Oleg Kovalsky, Feng-Di T. Lung, Peter P. Roller & Albert J. FornaceJr.Jr.. (2001) Oligomerization of Human Gadd45a Protein. Journal of Biological Chemistry 276:42, pages 39330-39339.
Crossref
Robert B. Lorsbach & James R. Downing. (2001) The Role of the AML1 Transcription Factor in Leukemogenesis. International Journal of Hematology 74:3, pages 258-265.
Crossref
Myriam Alcalay, Annette Orleth, Carla Sebastiani, Natalia Meani, Ferdinando Chiaradonna, Cristina Casciari, Maria Teresa Sciurpi, Vania Gelmetti, Daniela Riganelli, Saverio Minucci, Marta Fagioli & Pier Giuseppe Pelicci. (2001) Common themes in the pathogenesis of acute myeloid leukemia. Oncogene 20:40, pages 5680-5694.
Crossref
Jonathan D Licht. (2001) AML1 and the AML1-ETO fusion protein in the pathogenesis of t(8;21) AML. Oncogene 20:40, pages 5660-5679.
Crossref
Scott W. Hiebert, Bart Lutterbach & Joseph Amann. (2001) Role of co-repressors in transcriptional repression mediated by the t(8;21), t(16;21), t(12;21), and inv(16) fusion proteins. Current Opinion in Hematology 8:4, pages 197-200.
Crossref
Saverio Minucci, Clara Nervi, Francesco Lo Coco & Pier Giuseppe Pelicci. (2001) Histone deacetylases: a common molecular target for differentiation treatment of acute myeloid leukemias?. Oncogene 20:24, pages 3110-3115.
Crossref
Daniela Hildebrand, Jens Tiefenbach, Thorsten Heinzel, Manuel Grez & Alexander B. Maurer. (2001) Multiple Regions of ETO Cooperate in Transcriptional Repression. Journal of Biological Chemistry 276:13, pages 9889-9895.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.