Advanced search
Publication Cover
Molecular and Cellular Biology Volume 21, 2001 - Issue 1
Submit an article Journal homepage
179
Views
448
CrossRef citations to date
0
Altmetric
DNA Dynamics and Chromosome Structure

Stimulation of Homologous Recombination through Targeted Cleavage by Chimeric Nucleases

Marina Bibikova1 Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah84132
,
Dana Carroll1 Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah84132Correspondence[email protected] [email protected]
,
David J. Segal1 Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah84132
,
Jonathan K. Trautman1 Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah84132
,
Jeff Smith2 Department of Environmental Health Sciences, The Johns Hopkins University School of Hygiene and Public Health;3 Department of Biophysics and Biophysical Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland21205
,
Yang-Gyun Kim2 Department of Environmental Health Sciences, The Johns Hopkins University School of Hygiene and Public Health
&
Srinivasan Chandrasegaran2 Department of Environmental Health Sciences, The Johns Hopkins University School of Hygiene and Public HealthCorrespondence[email protected] [email protected]
 show all
Pages 289-297 | Received 28 Aug 2000, Accepted 05 Oct 2000, Published online: 28 Mar 2023

Citations (448)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (9)

Garima Thapliyal, Maneesh S. Bhandari, Ramu S. Vemanna, Shailesh Pandey, Rajendra K. Meena & Santan Barthwal. (2023) Engineering traits through CRISPR/cas genome editing in woody species to improve forest diversity and yield. Critical Reviews in Biotechnology 43:6, pages 884-903.
Read now
Britt Hanson, Matthew J.A. Wood & Thomas C. Roberts. (2021) Molecular correction of Duchenne muscular dystrophy by splice modulation and gene editing. RNA Biology 18:7, pages 1048-1062.
Read now
Marta Trevisan, Giorgio Palù & Luisa Barzon. (2017) Genome editing technologies to fight infectious diseases. Expert Review of Anti-infective Therapy 15:11, pages 1001-1013.
Read now
Rajagopal N. Aravalli & Clifford J. Steer. (2016) Gene editing technology as an approach to the treatment of liver diseases. Expert Opinion on Biological Therapy 16:5, pages 595-608.
Read now
Han B Lee, Zachary L Sebo, Ying Peng & Yi Guo. (2015) An optimized TALEN application for mutagenesis and screening in Drosophila melanogaster . Cellular Logistics 5:1.
Read now
Olivier Humbert, Luther Davis & Nancy Maizels. (2012) Targeted gene therapies: tools, applications, optimization. Critical Reviews in Biochemistry and Molecular Biology 47:3, pages 264-281.
Read now
Matthew Porteus. (2007) Using Homologous Recombination to Manipulate the Genome of Human Somatic Cells. Biotechnology and Genetic Engineering Reviews 24:1, pages 195-212.
Read now
Matthew H. Porteus, Toni Cathomen, Matthew D. Weitzman & David Baltimore. (2003) Efficient Gene Targeting Mediated by Adeno-Associated Virus and DNA Double-Strand Breaks. Molecular and Cellular Biology 23:10, pages 3558-3565.
Read now
Daniel G. Miller, Lisa M. Petek & David W. Russell. (2003) Human Gene Targeting by Adeno-Associated Virus Vectors Is Enhanced by DNA Double-Strand Breaks. Molecular and Cellular Biology 23:10, pages 3550-3557.
Read now

Articles from other publishers (439)

Lara E. Graves, Ari Horton, Ian E. Alexander & Shubha Srinivasan. (2023) Gene Therapy for Paediatric Homozygous Familial Hypercholesterolaemia. Heart, Lung and Circulation 32:7, pages 769-779.
Crossref
Anshu Sahu, Rita Verma, Uma Gupta, Shashi Kashyap & Indraneel Sanyal. (2023) An Overview of Targeted Genome Editing Strategies for Reducing the Biosynthesis of Phytic Acid: an Anti-nutrient in Crop Plants. Molecular Biotechnology.
Crossref
Kabhilan Mohan, Sushil Kumar Dubey, Kyungsik Jung, Rashmi Dubey, Qing Jun Wang, Subhash Prajapati, Jacob Roney, Jennifer Abney & Mark Ellsworth Kleinman. (2023) Long-Term Evaluation of Retinal Morphology and Function in Rosa26-Cas9 Knock-In Mice. International Journal of Molecular Sciences 24:6, pages 5186.
Crossref
Zulqurnain Khan, Sultan Habibullah Khan, Aftab Ahmed, Muhammad Umar Iqbal, Muhammad Salman Mubarik, Muhammad Zubair Ghouri, Furqan Ahmad, Saba Yaseen, Zulfiqar Ali, Asif Ali Khan & Muhammad Tehseen Azhar. (2023) Genome editing in cotton: challenges and opportunities. Journal of Cotton Research 6:1.
Crossref
Annelise Cassidy, Melda Onal & Stephane Pelletier. (2023) Novel methods for the generation of genetically engineered animal models. Bone 167, pages 116612.
Crossref
Shanna L. WhiteKevyn Hart & Donald B. Kohn. (2023) Diverse Approaches to Gene Therapy of Sickle Cell Disease. Annual Review of Medicine 74:1, pages 473-487.
Crossref
Sebastiano Giallongo, Oriana Lo Re, Igor Resnick, Marco Raffaele & Manlio Vinciguerra. 2023. Genome Editing in Cardiovascular and Metabolic Diseases. Genome Editing in Cardiovascular and Metabolic Diseases 275 298 .
Lluis Montoliu. 2023. Transgenesis. Transgenesis 1 32 .
N. MatinyanC.J. Potter. 2022. Sensory ecology of disease vectors. Sensory ecology of disease vectors 743 771 .
Muhammad Jawad Akbar Awan, Komal Pervaiz, Awais Rasheed, Imran Amin, Nasir A. Saeed, Kanwarpal S. Dhugga & Shahid Mansoor. (2022) Genome edited wheat- current advances for the second green revolution. Biotechnology Advances 60, pages 108006.
Crossref
Chandranandani Negi, Neeraj Kumar Vasistha, Dharmendra Singh, Pritesh Vyas & H. S. Dhaliwal. (2022) Application of CRISPR-Mediated Gene Editing for Crop Improvement. Molecular Biotechnology 64:11, pages 1198-1217.
Crossref
Jeffrey Kim, Etienne W. Daadi, Thomas Oh, Elyas S. Daadi & Marcel M. Daadi. (2022) Human Induced Pluripotent Stem Cell Phenotyping and Preclinical Modeling of Familial Parkinson’s Disease. Genes 13:11, pages 1937.
Crossref
Lilian Hasegawa Florentino, Rayane Nunes Lima & Mayla D.C. Molinari. 2022. Soybean - Recent Advances in Research and Applications. Soybean - Recent Advances in Research and Applications.
Vojtěch Hudzieczek, Roman Hobza, Petr Cápal, Jan Šafář & Jaroslav Doležel. (2022) If Mendel Was Using CRISPR: Genome Editing Meets Non‐Mendelian Inheritance. Advanced Functional Materials 32:37, pages 2202585.
Crossref
Tautvydas Karvelis & Virginijus Siksnys. 2022. Crispr. Crispr 53 69 .
Ching-Fu Tu, Chin-kai Chuang & Tien-Shuh Yang. (2022) The application of new breeding technology based on gene editing in pig industry — A review. Animal Bioscience 35:6, pages 791-803.
Crossref
Ying Hou, Xin Zhang, Xia Sun, Qiaohong Qin, Di Chen, Min Jia & Yulong Chen. (2022) Genetically modified rabbit models for cardiovascular medicine. European Journal of Pharmacology 922, pages 174890.
Crossref
O. Yu. Barkova, T. A. Larkina, A. A. Krutikova, E. A. Polteva, Yu. S. Shcherbakov, G. K. Peglivanyan & M. V. Pozovnikova. (2022) Innovative Approaches to Genome Editing in Chickens. Cytology and Genetics 56:2, pages 196-207.
Crossref
Nagaraj Bharathkumar, Abraham Sunil, Prabhakar Meera, Sam Aksah, Muthu Kannan, Konda Mani Saravanan & Thirunavukarasou Anand. (2021) CRISPR/Cas-Based Modifications for Therapeutic Applications: A Review. Molecular Biotechnology 64:4, pages 355-372.
Crossref
Marcello Maresca. 2022. Genome Editing in Drug Discovery. Genome Editing in Drug Discovery 9 17 .
Steve Rees. 2022. Genome Editing in Drug Discovery. Genome Editing in Drug Discovery 3 7 .
Simrika Thapa, Cristobal Marrero Winkens, Waqas Tahir, Maria I. Arifin, Sabine Gilch & Hermann M. Schatzl. (2022) Gene-Edited Cell Models to Study Chronic Wasting Disease. Viruses 14:3, pages 609.
Crossref
Yanxin Xu, Chen Chen, Yaxin Guo, Shengyun Hu & Zhenqiang Sun. (2022) Effect of CRISPR/Cas9-Edited PD-1/PD-L1 on Tumor Immunity and Immunotherapy. Frontiers in Immunology 13.
Crossref
Tibor Hornyik, Marina Rieder, Alessandro Castiglione, Peter Major, Istvan Baczko, Michael Brunner, Gideon Koren & Katja E. Odening. (2021) Transgenic rabbit models for cardiac disease research. British Journal of Pharmacology 179:5, pages 938-957.
Crossref
Ator Ashoti, Francesco Limone, Melissa van Kranenburg, Anna Alemany, Mirna Baak, Judith Vivié, Frederica Piccioni, Pascale F. Dijkers, Menno Creyghton, Kevin Eggan & Niels Geijsen. (2022) Considerations and practical implications of performing a phenotypic CRISPR/Cas survival screen. PLOS ONE 17:2, pages e0263262.
Crossref
Sergio Navarro-Serna, Celia Piñeiro-Silva, Chiara Luongo, John Parrington, Raquel Romar & Joaquín Gadea. (2022) Effect of Aphidicolin, a Reversible Inhibitor of Eukaryotic Nuclear DNA Replication, on the Production of Genetically Modified Porcine Embryos by CRISPR/Cas9. International Journal of Molecular Sciences 23:4, pages 2135.
Crossref
Alaleh Rezalotfi, Lea Fritz, Reinhold Förster & Berislav Bošnjak. (2022) Challenges of CRISPR-Based Gene Editing in Primary T Cells. International Journal of Molecular Sciences 23:3, pages 1689.
Crossref
Simon E Tröder & Branko Zevnik. (2021) History of genome editing: From meganucleases to CRISPR. Laboratory Animals 56:1, pages 60-68.
Crossref
Swati Bijlani, Ka Ming Pang, Venkatesh Sivanandam, Amanpreet Singh & Saswati Chatterjee. (2022) The Role of Recombinant AAV in Precise Genome Editing. Frontiers in Genome Editing 3.
Crossref
Tolulope E. Ayo & Hao Xu. (2022) Generating a New sgRNA Vector, pGL3-U6-sgRNA-PGK-mRFP-T2A-PuroR, to Improve Base Editing. Journal of Genome Editing and Regulation 2, pages 1-6.
Crossref
Shengyao Zhi, Yuxi Chen, Guanglan Wu, Jinkun Wen, Jinni Wu, Qianyi Liu, Yang Li, Rui Kang, Sihui Hu, Jiahui Wang, Puping Liang & Junjiu Huang. (2022) Dual-AAV delivering split prime editor system for in vivo genome editing. Molecular Therapy 30:1, pages 283-294.
Crossref
David S. Booth & Nicole King. 2022. Emerging Model Systems in Developmental Biology. Emerging Model Systems in Developmental Biology 73 91 .
Carlos Barreiro & Carlos García-Estrada. 2022. New Frontiers and Applications of Synthetic Biology. New Frontiers and Applications of Synthetic Biology 45 65 .
Stephen Neidle & Mark Sanderson. 2022. Principles of Nucleic Acid Structure. Principles of Nucleic Acid Structure 347 396 .
Aditi Arya, Shristy Gautam, Sonia Goel, Sapna Grewal & Malini Bhattacharyya. 2022. Phytochemical Genomics. Phytochemical Genomics 521 544 .
Nayla Munawar & Aftab Ahmad. 2022. The CRISPR/Cas Tool Kit for Genome Editing. The CRISPR/Cas Tool Kit for Genome Editing 1 28 .
Rajan KatochRajan Katoch. 2022. Nutritional Quality Management of Forages in the Himalayan Region. Nutritional Quality Management of Forages in the Himalayan Region 493 527 .
Montoliu Lluis. 2020. Encyclopedia of Astrobiology. Encyclopedia of Astrobiology 1 2 .
Dimple Sharma, Harmanpreet Kaur, Harsimran Kaur Kapoor, Rajat Sharma, Harpreet Kaur & Mohd Kyum. 2022. Genome Editing. Genome Editing 71 101 .
S. Navarro-Serna, C. Piñeiro-Silva, R. Romar, J. Parrington & J. Gadea. 2022. Sustainable Agriculture Reviews 57. Sustainable Agriculture Reviews 57 71 130 .
Kaushik Ghose, Ning Yuan, Lavanya Dampanaboina & Venugopal Mendu. 2022. Cisgenic Crops: Potential and Prospects. Cisgenic Crops: Potential and Prospects 257 279 .
Yanni Schneider, Jeanette Wihan, Soeren Turan & Jürgen Winkler. 2022. Brain Organoids in Research and Therapy. Brain Organoids in Research and Therapy 35 61 .
Lluis Montoliu. 2022. Applications of Genome Modulation and Editing. Applications of Genome Modulation and Editing 3 28 .
Sumi Rana, Pooja Rani Aggarwal, Varsa Shukla, Urmi Giri, Shubham Verma & Mehanathan Muthamilarasan. 2022. Plant Gene Silencing. Plant Gene Silencing 37 69 .
Samantha Shaltz & Sue Jinks-Robertson. (2021) Mutagenic repair of a ZFN-induced double-strand break in yeast: Effects of cleavage site sequence and spacer size. DNA Repair 108, pages 103228.
Crossref
Nasir Javaid & Sangdun Choi. (2021) CRISPR/Cas System and Factors Affecting Its Precision and Efficiency. Frontiers in Cell and Developmental Biology 9.
Crossref
Chuan-Chuan Chao, Po-Wen Shen, Tsai-Yu Tzeng, Hsing-Jien Kung, Ting-Fen Tsai & Yu-Hui Wong. (2021) Human iPSC-Derived Neurons as A Platform for Deciphering the Mechanisms behind Brain Aging. Biomedicines 9:11, pages 1635.
Crossref
Chin-Kai Chuang & Wei-Ming Lin. (2021) Points of View on the Tools for Genome/Gene Editing. International Journal of Molecular Sciences 22:18, pages 9872.
Crossref
Seyed Ahmad Rasoulinejad & Faezeh Maroufi. (2021) CRISPR-Based Genome Editing as a New Therapeutic Tool in Retinal Diseases. Molecular Biotechnology 63:9, pages 768-779.
Crossref
Wei Sheng Siew, Yin Quan Tang, Chee Kei Kong, Bey-Hing Goh, Serena Zacchigna, Kamal Dua, Dinesh Kumar Chellappan, Acharaporn Duangjai, Surasak Saokaew, Pochamana Phisalprapa & Wei Hsum Yap. (2021) Harnessing the Potential of CRISPR/Cas in Atherosclerosis: Disease Modeling and Therapeutic Applications. International Journal of Molecular Sciences 22:16, pages 8422.
Crossref
Jonathan A. Arnesen, Jakob Blæsbjerg Hoof, Helene Faustrup Kildegaard & Irina Borodina. 2021. Metabolic Engineering. Metabolic Engineering 301 337 .
Alok Kumar Singh, Sivaprakash Ramalingam, Desirazu N. Rao & Srinivasan Chandrasegaran. (2021) Genome Editing Revolution in Life Sciences. Resonance 26:7, pages 971-998.
Crossref
Nicolò Zuin Fantoni, Tom Brown & Andrew Kellett. (2021) DNA‐Targeted Metallodrugs: An Untapped Source of Artificial Gene Editing Technology. ChemBioChem 22:13, pages 2184-2205.
Crossref
Aamir Raina, Parmeshwar K. Sahu, Rafiul Amin Laskar, Nitika Rajora, Richa Sao, Samiullah Khan & Rais A. Ganai. (2021) Mechanisms of Genome Maintenance in Plants: Playing It Safe With Breaks and Bumps. Frontiers in Genetics 12.
Crossref
Heeyoung Seok, Rui Deng, Douglas B. Cowan & Da-Zhi Wang. (2021) Application of CRISPR-Cas9 gene editing for congenital heart disease. Clinical and Experimental Pediatrics 64:6, pages 269-279.
Crossref
Yashashree Karpe, Zhenyu Chen & Xue-Jun Li. (2021) Stem Cell Models and Gene Targeting for Human Motor Neuron Diseases. Pharmaceuticals 14:6, pages 565.
Crossref
Matthew N. George, Karla F. Leavens & Paul Gadue. (2021) Genome Editing Human Pluripotent Stem Cells to Model β-Cell Disease and Unmask Novel Genetic Modifiers. Frontiers in Endocrinology 12.
Crossref
Oliver Xiaoou Dong & Pamela C. Ronald. (2021) Targeted DNA insertion in plants. Proceedings of the National Academy of Sciences 118:22.
Crossref
Dana Carroll. (2021) A short, idiosyncratic history of genome editing. Gene and Genome Editing 1, pages 100002.
Crossref
Henrik U. Stotz & Nobuya Koizuka. 2021. Molecular Biology and Biotechnology. Molecular Biology and Biotechnology 287 297 .
Kirti Prasad, Anila George, Nithin Sam Ravi & Kumarasamypet M. Mohankumar. (2021) CRISPR/Cas based gene editing: marking a new era in medical science. Molecular Biology Reports 48:5, pages 4879-4895.
Crossref
Lin Wang, Zhaohui Ye & Yoon-Young Jang. (2021) Convergence of human pluripotent stem cell, organoid, and genome editing technologies. Experimental Biology and Medicine 246:7, pages 861-875.
Crossref
Jae Hoon Lee, Hyo Jun Won, Phuong Hoang Nguyen Tran, Sun‐mi Lee, Ho‐Youn Kim & Je Hyeong Jung. (2021) Improving lignocellulosic biofuel production by CRISPR/Cas9‐mediated lignin modification in barley. GCB Bioenergy 13:4, pages 742-752.
Crossref
Meng Zhang, Che Yang, Ipek Tasan & Huimin Zhao. (2021) Expanding the Potential of Mammalian Genome Engineering via Targeted DNA Integration . ACS Synthetic Biology 10:3, pages 429-446.
Crossref
Amy McTague, Giada Rossignoli, Arianna Ferrini, Serena Barral & Manju A. Kurian. (2021) Genome Editing in iPSC-Based Neural Systems: From Disease Models to Future Therapeutic Strategies. Frontiers in Genome Editing 3.
Crossref
Krishan Mohan Rai & Harpal Singh. 2021. Genome Engineering for Crop Improvement. Genome Engineering for Crop Improvement 199 209 .
Sergio Navarro-SernaAlaa HachemAnaluce Canha-GouveiaAli HanbashiGabriela GarrappaJordana S. LopesEvelyne París-OllerLucía Sarrías-GilCesar Flores-FloresAndrew BassettRaul SánchezPablo Bermejo-ÁlvarezCarmen MatásRaquel RomarJohn ParringtonJoaquín Gadea. (2021) Generation of Nonmosaic, Two-Pore Channel 2 Biallelic Knockout Pigs in One Generation by CRISPR-Cas9 Microinjection Before Oocyte Insemination. The CRISPR Journal 4:1, pages 132-146.
Crossref
Ibrahim Ilker Ozyigit, Hasan Can & Ilhan Dogan. (2020) Phytoremediation using genetically engineered plants to remove metals: a review. Environmental Chemistry Letters 19:1, pages 669-698.
Crossref
Iuri Viotti Perisse, Zhiqiang Fan, Galina N. Singina, Kenneth L. White & Irina A. Polejaeva. (2021) Improvements in Gene Editing Technology Boost Its Applications in Livestock. Frontiers in Genetics 11.
Crossref
Ujin Shin & Vincent Brondani. (2021) Analysis of Wild Type LbCpf1 Protein, and PAM Recognition Variants, in a Cellular Context. Frontiers in Genetics 11.
Crossref
Vincent Brondani. (2021) In vitro analysis of site specific nuclease selectivity by NGS. AIMS Bioengineering 8:4, pages 235-242.
Crossref
Xuanting Tang. (2021) CRISPR/Cas9-based genome engineering in HIV gene therapy. E3S Web of Conferences 233, pages 02004.
Crossref
Merve Uslu, Pınar Siyah, Andrew John Harvey & Fatih Kocabaş. 2021. Reprogramming the Genome: CRISPR-Cas-based Human Disease Therapy. Reprogramming the Genome: CRISPR-Cas-based Human Disease Therapy 89 127 .
Shubhchintan Randhawa & Shatakshi Sengar. 2021. Advances in CRISPR/Cas and Related Technologies. Advances in CRISPR/Cas and Related Technologies 1 62 .
Munshi Azad Hossain. 2021. Advances in CRISPR/Cas and Related Technologies. Advances in CRISPR/Cas and Related Technologies 63 83 .
Giulia Maule, Marjolein Ensinck, Mattijs Bulcaen & Marianne S. Carlon. 2021. Curing Genetic Diseases Through Genome Reprogramming. Curing Genetic Diseases Through Genome Reprogramming 185 224 .
Ashok Kumar, Sonia Chadha & Devashish Rath. 2021. Fungi Bio-Prospects in Sustainable Agriculture, Environment and Nano-technology. Fungi Bio-Prospects in Sustainable Agriculture, Environment and Nano-technology 541 576 .
Mark Isalan. 2021. Encyclopedia of Biological Chemistry III. Encyclopedia of Biological Chemistry III 506 516 .
Rakesh Kumar, Narasimha Rao Nizampatnam, Minhaj Alam, Tarun K. Thakur & Anirudh Kumar. 2021. Omics Technologies for Sustainable Agriculture and Global Food Security Volume 1. Omics Technologies for Sustainable Agriculture and Global Food Security Volume 1 213 240 .
Eric Paul Bennett, Bent Larsen Petersen, Ida Elisabeth Johansen, Yiyuan Niu, Zhang Yang, Christopher Aled Chamberlain, Özcan Met, Hans H Wandall & Morten Frödin. (2020) INDEL detection, the ‘Achilles heel’ of precise genome editing: a survey of methods for accurate profiling of gene editing induced indels. Nucleic Acids Research 48:21, pages 11958-11981.
Crossref
Ahmad M. Khalil. (2020) The genome editing revolution: review. Journal of Genetic Engineering and Biotechnology 18:1.
Crossref
Abdellah Barakate, Ewan Keir, Helena Oakey & Claire Halpin. (2020) Stimulation of homologous recombination in plants expressing heterologous recombinases. BMC Plant Biology 20:1.
Crossref
Seren Marsh, Britt Hanson, Matthew J.A. Wood, Miguel A. Varela & Thomas C. Roberts. (2020) Application of CRISPR-Cas9-Mediated Genome Editing for the Treatment of Myotonic Dystrophy Type 1. Molecular Therapy 28:12, pages 2527-2539.
Crossref
Faezeh Maroufi, Amirhosein Maali, Meghdad Abdollahpour-Alitappeh, Mohammad Hossein Ahmadi & Mehdi Azad. (2020) CRISPR-mediated modification of DNA methylation pattern in the new era of cancer therapy. Epigenomics 12:20, pages 1845-1859.
Crossref
Weimin ZhangLeslie A. MitchellJoel S. BaderJef D. Boeke. (2020) Synthetic Genomes. Annual Review of Biochemistry 89:1, pages 77-101.
Crossref
David S Booth & Nicole King. (2020) Genome editing enables reverse genetics of multicellular development in the choanoflagellate Salpingoeca rosetta. eLife 9.
Crossref
Sergio Navarro-Serna, Marcela Vilarino, Insung Park, Joaquin Gadea & Pablo Juan Ross. (2020) Livestock Gene Editing by One-step Embryo Manipulation. Journal of Equine Veterinary Science 89, pages 103025.
Crossref
Yangyang Ye, Xiang Zhang, Fei Xie, Bin Xu, Ping Xie, Ting Yang, Qian Shi, Chen-Yu Zhang, Yujing Zhang, Jiangning Chen, Xiaohong Jiang & Jing Li. (2020) An engineered exosome for delivering sgRNA:Cas9 ribonucleoprotein complex and genome editing in recipient cells. Biomaterials Science 8:10, pages 2966-2976.
Crossref
Haoyi WANG, Sen WU, Mario R. CAPECCHI & Rudolf JAENISCH. (2020) A brief review of genome editing technology for generating animal models. Frontiers of Agricultural Science and Engineering 7:2, pages 123.
Crossref
Grace A Meaker, Emma J Hair & Thomas E Gorochowski. (2020) Advances in engineering CRISPR-Cas9 as a molecular Swiss Army knife. Synthetic Biology 5:1.
Crossref
Sandra R. Bacman, P.A. Gammage, M. Minczuk & Carlos T. Moraes. 2020. Mitochondria, 3rd Edition. Mitochondria, 3rd Edition 441 487 .
V. Edwin Hillary, Stanislaus Antony Ceasar & S. Ignacimuthu. 2020. Genome Engineering via CRISPR-Cas9 System. Genome Engineering via CRISPR-Cas9 System 219 249 .
Sara Monteiro Lopes & Luís Pereira de Almeida. 2020. Handbook of Innovations in Central Nervous System Regenerative Medicine. Handbook of Innovations in Central Nervous System Regenerative Medicine 399 433 .
Donald B. Kohn. 2020. Stiehm's Immune Deficiencies. Stiehm's Immune Deficiencies 1215 1228 .
Lu Wen, Qiang Liu, Jingjing Xu, Xixi Liu, Chaoyi Shi, Zuwei Yang, Yili Zhang, Hong Xu, Jiang Liu, Hui Yang, Hefeng Huang, Jie Qiao, Fuchou Tang & Zi-Jiang Chen. (2019) Recent advances in mammalian reproductive biology. Science China Life Sciences 63:1, pages 18-58.
Crossref
Sohinee Bhattacharyya & Anindit Mukherjee. 2020. Biotechnology Business - Concept to Delivery. Biotechnology Business - Concept to Delivery 47 56 .
Marina Gertsenstein, Joffrey Mianné, Lydia Teboul & Lauryl M. J. Nutter. 2020. Transgenic Mouse. Transgenic Mouse 59 82 .
Zijun Huo, Jian Tu, Dung-Fang Lee & Ruiying Zhao. 2020. Immune Mediators in Cancer. Immune Mediators in Cancer 355 369 .
Will Bailis. 2020. Cell Reprogramming for Immunotherapy. Cell Reprogramming for Immunotherapy 223 230 .
Carlos G. Moscoso & Clifford J. Steer. (2019) Liver targeted gene therapy: Insights into emerging therapies. Drug Discovery Today: Technologies 34, pages 9-19.
Crossref
Hassan Bukhari & Thorsten Müller. (2019) Endogenous Fluorescence Tagging by CRISPR. Trends in Cell Biology 29:11, pages 912-928.
Crossref
Laia Bonjoch, Pilar Mur, Coral Arnau-Collell, Gardenia Vargas-Parra, Bahar Shamloo, Sebastià Franch-Expósito, Marta Pineda, Gabriel Capellà, Batu Erman & Sergi Castellví-Bel. (2019) Approaches to functionally validate candidate genetic variants involved in colorectal cancer predisposition. Molecular Aspects of Medicine 69, pages 27-40.
Crossref
Wen Kang, Zhuoer Sun, Xingle Zhao, Xueling Wang, Yong Tao & Hao Wu. (2019) Gene editing based hearing impairment research and therapeutics. Neuroscience Letters 709, pages 134326.
Crossref
Xiaojie Xu, Tao Wan, Huhu Xin, Da Li, Hongming Pan, Jun Wu & Yuan Ping. (2019) Delivery of CRISPR/Cas9 for therapeutic genome editing. The Journal of Gene Medicine 21:7.
Crossref
Julia Jansing, Andreas Schiermeyer, Stefan Schillberg, Rainer Fischer & Luisa Bortesi. (2019) Genome Editing in Agriculture: Technical and Practical Considerations. International Journal of Molecular Sciences 20:12, pages 2888.
Crossref
Kevin Davies & Dana Carroll. (2019) Giving Genome Editing the Fingers: An Interview with Dana Carroll. The CRISPR Journal 2:3, pages 157-162.
Crossref
William Wang, Linlin Zhang, Xiangdong Wang & Yiming Zeng. (2019) The advances in CRISPR technology and 3D genome. Seminars in Cell & Developmental Biology 90, pages 54-61.
Crossref
Dimitre R. Simeonov & Alexander Marson. (2019) CRISPR-Based Tools in Immunity. Annual Review of Immunology 37:1, pages 571-597.
Crossref
Ali Zarei, Vahid Razban, Seyed Ebrahim Hosseini & Seyed Mohammad Bagher Tabei. (2019) Creating cell and animal models of human disease by genome editing using CRISPR/Cas9. The Journal of Gene Medicine 21:4, pages e3082.
Crossref
David E. Paschon, Stephanie Lussier, Tenzin Wangzor, Danny F. Xia, Patrick W. Li, Sarah J. Hinkley, Nicholas A. Scarlott, Stephen C. Lam, Adam J. Waite, Lynn N. Truong, Nimisha Gandhi, Bhakti N. Kadam, Deepak P. Patil, David A. Shivak, Gary K. Lee, Michael C. Holmes, Lei Zhang, Jeffrey C. Miller & Edward J. Rebar. (2019) Diversifying the structure of zinc finger nucleases for high-precision genome editing. Nature Communications 10:1.
Crossref
Wenyi Wu, Yanhui Yang & Hetian Lei. (2018) Progress in the application of CRISPR: From gene to base editing. Medicinal Research Reviews 39:2, pages 665-683.
Crossref
Katherine Shortt, Daniel P. Heruth, NiNi Zhang, Weibin Wu, Shipra Singh, Ding-You Li, Li Qin Zhang, Gerald J. Wyckoff, Lei S. Qi, Craig A. Friesen & Shui Qing Ye. (2019) Identification of Novel Regulatory Genes in APAP Induced Hepatocyte Toxicity by a Genome-Wide CRISPR-Cas9 Screen. Scientific Reports 9:1.
Crossref
José A. Ortega‐Escalante, Robyn Jasper & Stephen M. Miller. (2019) CRISPR /Cas9 mutagenesis in Volvox carteri . The Plant Journal 97:4, pages 661-672.
Crossref
Laure M. C. Leynaud-Kieffer, Samuel C. Curran, Irene Kim, Jon K. Magnuson, John M. Gladden, Scott E. Baker & Blake A. Simmons. (2019) A new approach to Cas9-based genome editing in Aspergillus niger that is precise, efficient and selectable. PLOS ONE 14:1, pages e0210243.
Crossref
Saeed Bozorg Qomi, Amir Asghari & Majid Mojarrad. (2019) An Overview Of The Crispr-Based Genomic- And Epigenome-Editing System: Function, Applications, And Challenges. Advanced Biomedical Research 8:1, pages 49.
Crossref
David T Ewart, Erik J Peterson & Clifford J Steer. (2019) Gene editing for inflammatory disorders. Annals of the Rheumatic Diseases 78:1, pages 6-15.
Crossref
Krishan Mohan Rai, Kaushik Ghose, Anshulika Rai, Harpal Singh, Rakesh Srivastava & Venugopal Mendu. 2019. Current Developments in Biotechnology and Bioengineering. Current Developments in Biotechnology and Bioengineering 47 73 .
Sudhir P. Singh, Shilpi Bansal & Ashok Pandey. 2019. Current Developments in Biotechnology and Bioengineering. Current Developments in Biotechnology and Bioengineering 3 22 .
Jaykumar Patel & Avinash Mishra. 2019. Plant Biotechnology: Progress in Genomic Era. Plant Biotechnology: Progress in Genomic Era 147 174 .
Erik J. Quiroz & Amy L. Ryan (Firth). 2019. Stem Cell-Based Therapy for Lung Disease. Stem Cell-Based Therapy for Lung Disease 153 178 .
Stephen Novak. 2019. Transgenic Plants. Transgenic Plants 295 310 .
Yutaka Yamamoto & Susan A. Gerbi. (2018) Making ends meet: targeted integration of DNA fragments by genome editing. Chromosoma 127:4, pages 405-420.
Crossref
Ze-Xia Gao & Bruce W. Draper. 2018. Sex Control in Aquaculture. Sex Control in Aquaculture 117 136 .
Marta Martinez-Lage, Pilar Puig-Serra, Pablo Menendez, Raul Torres-Ruiz & Sandra Rodriguez-Perales. (2018) CRISPR/Cas9 for Cancer Therapy: Hopes and Challenges. Biomedicines 6:4, pages 105.
Crossref
Zachary WareJoncas, Jarryd M. Campbell, Gabriel Martínez-Gálvez, William A. C. Gendron, Michael A. Barry, Peter C. Harris, Caroline R. Sussman & Stephen C. Ekker. (2018) Precision gene editing technology and applications in nephrology. Nature Reviews Nephrology 14:11, pages 663-677.
Crossref
Brandon W. Simone, Gabriel Martínez-Gálvez, Zachary WareJoncas & Stephen C. Ekker. (2018) Fishing for understanding: Unlocking the zebrafish gene editor’s toolbox. Methods 150, pages 3-10.
Crossref
Jennifer Viegas. (2018) Profile of Dana Carroll. Proceedings of the National Academy of Sciences 115:38, pages 9331-9333.
Crossref
Channabasavaiah B. Gurumurthy & Pablo Perez-Pinera. (2018) Technological advances in integrating multi-kilobase DNA sequences into genomes. Current Opinion in Biomedical Engineering 7, pages 16-23.
Crossref
Christine L. Xu, Karen Sophia Park & Stephen H. Tsang. (2018) CRISPR/Cas9 genome surgery for retinal diseases. Drug Discovery Today: Technologies 28, pages 23-32.
Crossref
Kelsey P. Ringer, Mark G. Roth, Mitchell S. Garey, Ted B. Piorczynski, Arminda Suli, Jason M. Hansen & Jonathan K. Alder. (2018) Comparative analysis of lipid-mediated CRISPR-Cas9 genome editing techniques. Cell Biology International 42:7, pages 849-858.
Crossref
Adam J Bogdanove, Andrew Bohm, Jeffrey C Miller, Richard D Morgan & Barry L Stoddard. (2018) Engineering altered protein–DNA recognition specificity. Nucleic Acids Research 46:10, pages 4845-4871.
Crossref
Daniel Poppe, Jonas Doerr, Marion Schneider, Ruven Wilkens, Julius A. Steinbeck, Julia Ladewig, Allison Tam, David E. Paschon, Philip D. Gregory, Andreas Reik, Christa E. Müller, Philipp Koch & Oliver Brüstle. (2018) Genome Editing in Neuroepithelial Stem Cells to Generate Human Neurons with High Adenosine-Releasing Capacity. Stem Cells Translational Medicine 7:6, pages 477-486.
Crossref
Rajagopal N. Aravalli & Clifford J. Steer. (2018) CRISPR/Cas9 therapeutics for liver diseases. Journal of Cellular Biochemistry 119:6, pages 4265-4278.
Crossref
Mazhar Adli. (2018) The CRISPR tool kit for genome editing and beyond. Nature Communications 9:1.
Crossref
Lauren E. Woodard, Daniel L. Galvan & Matthew H. Wilson. 2018. Synthetic Biology. Synthetic Biology 33 47 .
Zulqurnain Khan, Sultan Habibullah Khan, Muhammad Salman Mubarik & Aftab Ahmad. 2018. Past, Present and Future Trends in Cotton Breeding. Past, Present and Future Trends in Cotton Breeding.
Spencer C. Knight, Robert Tjian & Jennifer A. Doudna. (2018) Genomes in Focus: Development and Applications of CRISPR-Cas9 Imaging Technologies. Angewandte Chemie International Edition 57:16, pages 4329-4337.
Crossref
Spencer C. Knight, Robert Tjian & Jennifer A. Doudna. (2018) Genome im Fokus: Entwicklung und Anwendungen von CRISPR-Cas9-Bildgebungstechnologien. Angewandte Chemie 130:16, pages 4412-4420.
Crossref
Evan A. Heiderscheit, Asuka Eguchi, Mackenzie C. Spurgat & Aseem Z. Ansari. (2018) Reprogramming cell fate with artificial transcription factors. FEBS Letters 592:6, pages 888-900.
Crossref
Fyodor D. Urnov. (2018) Genome Editing B.C. (Before CRISPR): Lasting Lessons from the “Old Testament”. The CRISPR Journal 1:1, pages 34-46.
Crossref
A.C. Veith, C. Chu & B. Moorthy. 2018. Comprehensive Toxicology. Comprehensive Toxicology 484 497 .
Rashi Khandelwal & Mukesh Jain. 2018. Pulse Improvement. Pulse Improvement 219 234 .
Zoe Hilioti. 2018. Zinc Finger Proteins. Zinc Finger Proteins 187 199 .
Aimee Malzahn, Levi Lowder & Yiping Qi. (2017) Plant genome editing with TALEN and CRISPR. Cell & Bioscience 7:1.
Crossref
Raj Chari & George M. Church. (2017) Beyond editing to writing large genomes. Nature Reviews Genetics 18:12, pages 749-760.
Crossref
Kiran Musunuru. (2017) Genome Editing. Journal of the American College of Cardiology 70:22, pages 2808-2821.
Crossref
Michel Morange. (2017) What history tells us XLIV: The construction of the zinc finger nucleases. Journal of Biosciences 42:4, pages 527-530.
Crossref
Roberta Sarno, Yoan Vicq, Norio Uematsu, Marine Luka, Clement Lapierre, Dana Carroll, Giacomo Bastianelli, Alexandre Serero & Alain Nicolas. (2017) Programming sites of meiotic crossovers using Spo11 fusion proteins. Nucleic Acids Research 45:19, pages e164-e164.
Crossref
Ping Huang, Dongdong Tong, Jing Sun, Qing Li & Fenghe Zhang. (2017) Generation and characterization of a human oral squamous carcinoma cell line SCC-9 with CRISPR/Cas9-mediated deletion of the p75 neurotrophin receptor. Archives of Oral Biology 82, pages 223-232.
Crossref
Ianis G. Matsoukas. (2017) Commentary: CRISPR–Cas Encoding of a Digital Movie into the Genomes of a Population of Living Bacteria. Frontiers in Bioengineering and Biotechnology 5.
Crossref
Srinivasan Chandrasegaran, C. Korin Bullen & Dana Carroll. (2017) Genome editing of human embryos: to edit or not to edit, that is the question. Journal of Clinical Investigation 127:10, pages 3588-3590.
Crossref
Wenyi Wu, Luosheng Tang, Patricia A. D'Amore & Hetian Lei. (2017) Application of CRISPR-Cas9 in eye disease. Experimental Eye Research 161, pages 116-123.
Crossref
Almudena Fernández, Santiago Josa & Lluis Montoliu. (2017) A history of genome editing in mammals. Mammalian Genome 28:7-8, pages 237-246.
Crossref
Sumitra Shankar, Deepti Prasad, Rahul Sanawar, Ani V. Das & M. Radhakrishna Pillai. (2017) TALEN based HPV-E7 editing triggers necrotic cell death in cervical cancer cells. Scientific Reports 7:1.
Crossref
Kandasamy Ulaganathan, Sravanthi Goud, Madhavi Reddy & Ulaganathan Kayalvili. (2017) Genome engineering for breaking barriers in lignocellulosic bioethanol production. Renewable and Sustainable Energy Reviews 74, pages 1080-1107.
Crossref
Franziska Voellmy & Rune Linding. 2017. Systems Biology. Systems Biology 367 392 .
Patrick Ovando-Roche, Anastasios Georgiadis, Alexander J. Smith, Rachael A. Pearson & Robin R. Ali. (2017) Harnessing the Potential of Human Pluripotent Stem Cells and Gene Editing for the Treatment of Retinal Degeneration. Current Stem Cell Reports 3:2, pages 112-123.
Crossref
Puping Liang, Xiya Zhang, Yuxi Chen & Junjiu Huang. (2017) Developmental history and application of CRISPR in human disease. The Journal of Gene Medicine 19:6-7, pages e2963.
Crossref
Emmanouil Metzakopian, Alex Strong, Vivek Iyer, Alex Hodgkins, Konstantinos Tzelepis, Liliana Antunes, Mathias J Friedrich, Qiaohua Kang, Teresa Davidson, Jacob Lamberth, Christina Hoffmann, Gregory D. Davis, George S. Vassiliou, William C. Skarnes & Allan Bradley. (2017) Enhancing the genome editing toolbox: genome wide CRISPR arrayed libraries. Scientific Reports 7:1.
Crossref
Matthew C. Canver, Daniel E. Bauer & Stuart H. Orkin. (2017) Functional interrogation of non-coding DNA through CRISPR genome editing. Methods 121-122, pages 118-129.
Crossref
Duri Rungger, Lisbeth Muster, Oleg Georgiev & Elisabeth Rungger-Brändle. (2017) Oocyte shuttle, a recombinant protein transporting donor DNA into the Xenopus oocyte in situ . Biology Open 6:2, pages 290-295.
Crossref
Simone Haas, Viviane Dettmer & Toni Cathomen. (2017) Therapeutic genome editing with engineered nucleases. Hämostaseologie 37:01, pages 45-52.
Crossref
Cheng An, Guangjing Zhu, Suzanne N. Martos, Xue Feng, Haimou Zhang, Yankai Jia & Zhibin Wang. (2017) TALEN-Mediated FLAG-Tagging of Endogenous Histone Methyltransferase DOT1L. Advances in Bioscience and Biotechnology 08:09, pages 311-323.
Crossref
Xiao-Jie Lu, Hong-Mei Sun, Yong Xu, Xi Yu & Biao Gu. (2017) The applications and advances of CRISPR-Cas9 in medical research. Briefings in Functional Genomics 16:1, pages 1-3.
Crossref
Raul Torres-Ruiz & Sandra Rodriguez-Perales. (2017) CRISPR-Cas9 technology: applications and human disease modelling. Briefings in Functional Genomics 16:1, pages 4-12.
Crossref
Alanna Strong & Kiran Musunuru. (2016) Genome editing in cardiovascular diseases. Nature Reviews Cardiology 14:1, pages 11-20.
Crossref
Mert Yanik, Brigitte Müller, Fei Song, Jacqueline Gall, Franziska Wagner, Wolfgang Wende, Birgit Lorenz & Knut Stieger. (2017) In vivo genome editing as a potential treatment strategy for inherited retinal dystrophies. Progress in Retinal and Eye Research 56, pages 1-18.
Crossref
D.R. Ede, N. Farhang, J.D. Stover & R.D. Bowles. 2017. Comprehensive Biomaterials II. Comprehensive Biomaterials II 589 599 .
Benjamin E. Epstein & David V. Schaffer. 2017. Precision Medicine, CRISPR, and Genome Engineering. Precision Medicine, CRISPR, and Genome Engineering 29 42 .
Yanpeng Wang, Yuan Zong & Caixia Gao. 2017. Wheat Biotechnology. Wheat Biotechnology 169 185 .
Vittavat Termglinchan, Timon Seeger, Caressa Chen, Joseph C. Wu & Ioannis Karakikes. 2017. Cardiac Gene Therapy. Cardiac Gene Therapy 55 68 .
Zhaoying Shi, Dandan Tian, Huhu Xin, Jingru Lian, Xiaogang Guo & Yonglong Chen. (2017) Targeted integration of genes in Xenopus tropicalis . genesis 55:1-2, pages e23006.
Crossref
Carmen Agustín-Pavón, Michal Mielcarek, Mireia Garriga-Canut & Mark Isalan. (2016) Deimmunization for gene therapy: host matching of synthetic zinc finger constructs enables long-term mutant Huntingtin repression in mice. Molecular Neurodegeneration 11:1.
Crossref
Thomas Gaj, Shannon J. Sirk, Sai-lan Shui & Jia Liu. (2016) Genome-Editing Technologies: Principles and Applications. Cold Spring Harbor Perspectives in Biology 8:12, pages a023754.
Crossref
Thomas Gaj & David V. Schaffer. (2016) Adeno-Associated Virus–Mediated Delivery of CRISPR–Cas Systems for Genome Engineering in Mammalian Cells. Cold Spring Harbor Protocols 2016:11, pages pdb.prot086868.
Crossref
Fangyuan Wang & Lei S. Qi. (2016) Applications of CRISPR Genome Engineering in Cell Biology. Trends in Cell Biology 26:11, pages 875-888.
Crossref
Ganesan Govindan & Sivaprakash Ramalingam. (2016) Programmable Site-Specific Nucleases for Targeted Genome Engineering in Higher Eukaryotes. Journal of Cellular Physiology 231:11, pages 2380-2392.
Crossref
Ayman Eid & Magdy M Mahfouz. (2016) Genome editing: the road of CRISPR/Cas9 from bench to clinic. Experimental & Molecular Medicine 48:10, pages e265-e265.
Crossref
Daniel Tianfang Ge, Cindy Tipping, Michael H Brodsky & Phillip D Zamore. (2016) Rapid Screening for CRISPR-Directed Editing of the Drosophila Genome Using white Coconversion . G3 Genes|Genomes|Genetics 6:10, pages 3197-3206.
Crossref
Jing Yao, Jiaojiao Huang & Jianguo Zhao. (2016) Genome editing revolutionize the creation of genetically modified pigs for modeling human diseases. Human Genetics 135:9, pages 1093-1105.
Crossref
Yoon-Young Jang & Zhaohui Ye. (2016) Gene correction in patient-specific iPSCs for therapy development and disease modeling. Human Genetics 135:9, pages 1041-1058.
Crossref
Ipek Tasan, Surbhi Jain & Huimin Zhao. (2016) Use of genome-editing tools to treat sickle cell disease. Human Genetics 135:9, pages 1011-1028.
Crossref
Josh Tycko, Vic E. Myer & Patrick D. Hsu. (2016) Methods for Optimizing CRISPR-Cas9 Genome Editing Specificity. Molecular Cell 63:3, pages 355-370.
Crossref
A. A. Chugunova, O. A. Dontsova & P. V. Sergiev. (2016) Methods of genome engineering: a new era of molecular biology. Biochemistry (Moscow) 81:7, pages 662-677.
Crossref
Patrick M. Shih, Yan Liang & Dominique Loqué. (2016) Biotechnology and synthetic biology approaches for metabolic engineering of bioenergy crops. The Plant Journal 87:1, pages 103-117.
Crossref
Sandy S.C. Hung, Tristan McCaughey, Olivia Swann, Alice Pébay & Alex W. Hewitt. (2016) Genome engineering in ophthalmology: Application of CRISPR/Cas to the treatment of eye disease. Progress in Retinal and Eye Research 53, pages 1-20.
Crossref
Z. Bősze, P. Major, I. Baczkó, K.E. Odening, L. Bodrogi, L. Hiripi & A. Varró. (2016) The potential impact of new generation transgenic methods on creating rabbit models of cardiac diseases. Progress in Biophysics and Molecular Biology 121:2, pages 123-130.
Crossref
Agieshkumar Pillai & S Elanthiraiyan. (2019) Genome editing tools and its potential applications in translational medicine- a brief overview.. Annals of SBV 5:1, pages 14-18.
Crossref
Matthew C. CanverStuart H. Orkin. (2016) Customizing the genome as therapy for the β-hemoglobinopathies. Blood 127:21, pages 2536-2545.
Crossref
Atsuo Kawahara, Yu Hisano, Satoshi Ota & Kiyohito Taimatsu. (2016) Site-Specific Integration of Exogenous Genes Using Genome Editing Technologies in Zebrafish. International Journal of Molecular Sciences 17:5, pages 727.
Crossref
Han B. Lee, Brynn N. Sundberg, Ashley N. Sigafoos & Karl J. Clark. (2016) Genome Engineering with TALE and CRISPR Systems in Neuroscience. Frontiers in Genetics 7.
Crossref

Displaying 200 of 448 citing articles. Use the download link below to view the full list of citing articles.

Download full citations list

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.