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Cell Growth and Development

Cyclic AMP-Mediated Inhibition of Cell Growth Requires the Small G Protein Rap1

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Pages 3671-3683 | Received 02 Feb 2001, Accepted 09 Mar 2001, Published online: 27 Mar 2023

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Z.A. Antonello & C. Nucera. 2014. Pathobiology of Human Disease. Pathobiology of Human Disease 1206 1222 .
Yanmei Zhang, Gaoyong Chen, Shuping Zhong, Fuchun Zheng, Fenfei Gao, Yicun Chen, Zhanqin Huang, Wenfeng Cai, Weiqiu Li, Xingping Liu, Yanshan Zheng, Han Xu & Ganggang Shi. (2013) N -n-Butyl Haloperidol Iodide Ameliorates Cardiomyocytes Hypoxia/Reoxygenation Injury by Extracellular Calcium-Dependent and -Independent Mechanisms . Oxidative Medicine and Cellular Longevity 2013, pages 1-12.
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Jeff S. Kruk, Maryam S. Vasefi, Hui Liu, John J. Heikkila & Michael A. Beazely. (2013) 5-HT1A receptors transactivate the platelet-derived growth factor receptor type beta in neuronal cells. Cellular Signalling 25:1, pages 133-143.
Crossref
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Crossref
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Vandana S. Nikam, Gesa Wecker, Ralph Schermuly, Ulf Rapp, Kirsten Szelepusa, Werner Seeger & Robert Voswinckel. (2011) Treprostinil Inhibits the Adhesion and Differentiation of Fibrocytes via the Cyclic Adenosine Monophosphate–Dependent and Ras-Proximate Protein–Dependent Inactivation of Extracellular Regulated Kinase. American Journal of Respiratory Cell and Molecular Biology 45:4, pages 692-703.
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Crossref
Philip C.N. Chiu, Ben S.T. Wong, Cheuk-Lun Lee, Kevin K.W. Lam, Man-Kin Chung, Kai-Fai Lee, Riitta Koistinen, Hannu Koistinen, Satish K. Gupta, Markku Seppälä & William S.B. Yeung. (2010) Zona pellucida-induced acrosome reaction in human spermatozoa is potentiated by glycodelin-A via down-regulation of extracellular signal-regulated kinases and up-regulation of zona pellucida-induced calcium influx. Human Reproduction 25:11, pages 2721-2733.
Crossref
Xiaojing Ye & Thomas J. Carew. (2010) Small G Protein Signaling in Neuronal Plasticity and Memory Formation: The Specific Role of Ras Family Proteins. Neuron 68:3, pages 340-361.
Crossref
William H. Walker. (2010) Non-classical actions of testosterone and spermatogenesis. Philosophical Transactions of the Royal Society B: Biological Sciences 365:1546, pages 1557-1569.
Crossref
C Schönherr, H-L Yang, M Vigny, R H Palmer & B Hallberg. (2010) Anaplastic lymphoma kinase activates the small GTPase Rap1 via the Rap1-specific GEF C3G in both neuroblastoma and PC12 cells. Oncogene 29:19, pages 2817-2830.
Crossref
John M. Schmitt, Ellen Abell, Andrea Wagner & Monika A. Davare. (2009) ERK activation and cell growth require CaM kinases in MCF-7 breast cancer cells. Molecular and Cellular Biochemistry 335:1-2, pages 155-171.
Crossref
Li Li, Shuai Wang, Anna Jezierski, Lilian Moalim-Nour, Kanishka Mohib, Robin J. Parks, Saverio Francesco Retta & Lisheng Wang. (2010) A Unique Interplay Between Rap1 and E-Cadherin in the Endocytic Pathway Regulates Self-Renewal of Human Embryonic Stem Cells    . Stem Cells 28:2, pages 247-257.
Crossref
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Crossref
Jens Selige, Hermann Tenor, Armin Hatzelmann & Torsten Dunkern. (2010) Cytokine-dependent balance of mitogenic effects in primary human lung fibroblasts related to cyclic AMP signaling and phosphodiesterase 4 inhibition. Journal of Cellular Physiology, pages n/a-n/a.
Crossref
Martin M. Edreira, Sheng Li, Daniel Hochbaum, Sergio Wong, Alemayehu A. Gorfe, Fernando Ribeiro-Neto, Virgil L. WoodsJr.Jr. & Daniel L. Altschuler. (2009) Phosphorylation-induced Conformational Changes in Rap1b. Journal of Biological Chemistry 284:40, pages 27480-27486.
Crossref
Lucia Stefanini, R. Claire Roden & Wolfgang Bergmeier. (2009) CalDAG-GEFI is at the nexus of calcium-dependent platelet activation. Blood 114:12, pages 2506-2514.
Crossref
Evgeny Weinberg, Ella Zeldich, Max M. Weinreb, Ofer Moses, Carlos Nemcovsky & Miron Weinreb. (2009) Prostaglandin E 2 inhibits the proliferation of human gingival fibroblasts via the EP 2 receptor and Epac . Journal of Cellular Biochemistry 108:1, pages 207-215.
Crossref
Xiaojing Ye, Justin L. Shobe, Shiv K. Sharma, Andreea Marina & Thomas J. Carew. (2008) Small G proteins exhibit pattern sensitivity in MAPK activation during the induction of memory and synaptic facilitation in Aplysia . Proceedings of the National Academy of Sciences 105:51, pages 20511-20516.
Crossref
Isabel Lastres-Becker, Antonio Fernández-Pérez, Beatriz Cebolla & Mario Vallejo. (2008) Pituitary adenylate cyclase-activating polypeptide stimulates glial fibrillary acidic protein gene expression in cortical precursor cells by activating Ras and Rap1. Molecular and Cellular Neuroscience 39:3, pages 291-301.
Crossref
Nancy Gerits, Sergiy Kostenko, Alexey Shiryaev, Mona Johannessen & Ugo Moens. (2008) Relations between the mitogen-activated protein kinase and the cAMP-dependent protein kinase pathways: Comradeship and hostility. Cellular Signalling 20:9, pages 1592-1607.
Crossref
Jian-Jun CUI. (2008) An integrated biological model for interferon signaling pathway and its gene polymorphisms. Hereditas (Beijing) 30:6, pages 788-794.
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Radoslaw M. Sobota, Pia J. Müller, Peter C. Heinrich & Fred Schaper. (2008) Prostaglandin E1 inhibits IL-6-induced MCP-1 expression by interfering specifically in IL-6-dependent ERK1/2, but not STAT3, activation. Biochemical Journal 412:1, pages 65-72.
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Reinoud Gosens, Sara S. Roscioni, Bart G.J. Dekkers, Tonio Pera, Martina Schmidt, Dedmer Schaafsma, Johan Zaagsma & Herman Meurs. (2008) Pharmacology of airway smooth muscle proliferation. European Journal of Pharmacology 585:2-3, pages 385-397.
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Angela M. Morton, Barbara McManus, Paul Garside, Allan McI. Mowat & Margaret M. Harnett. (2007) Inverse Rap1 and Phospho-ERK Expression Discriminate the Maintenance Phase of Tolerance and Priming of Antigen-Specific CD4+ T Cells In Vitro and In Vivo. The Journal of Immunology 179:12, pages 8026-8034.
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Maho Ishida, Tetsuo Mitsui, Koji Yamakawa, Nobuhiro Sugiyama, Wakaba Takahashi, Hiroki Shimura, Toyoshi Endo, Tetsurou Kobayashi & Jun Arita. (2007) Involvement of cAMP response element-binding protein in the regulation of cell proliferation and the prolactin promoter of lactotrophs in primary culture. American Journal of Physiology-Endocrinology and Metabolism 293:6, pages E1529-E1537.
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Nuria Palacios, Franco Sánchez-Franco, Miriam Fernández, Isabel Sánchez, Gemma Villuendas & Lucinda Cacicedo. (2007) Opposite effects of two PKA inhibitors on cAMP inhibition of IGF-I-induced oligodendrocyte development: A problem of unspecificity?. Brain Research 1178, pages 1-11.
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Piet W.L. Tas, Stepan Gambaryan & Norbert Roewer. (2007) Volatile anesthetics affect the morphology of rat glioma C6 cells via RhoA, ERK, and Akt activation. Journal of Cellular Biochemistry 102:2, pages 368-376.
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Samantha Q. Wales, Baiquan Li, Jennifer M. Laing & Laure Aurelian. (2007) The herpes simplex virus type 2 gene ICP10PK protects from apoptosis caused by nerve growth factor deprivation through inhibition of caspase-3 activation and XIAP up-regulation. Journal of Neurochemistry 0:0, pages 070630082917004-???.
Crossref
A E Carie & S M Sebti. (2007) A chemical biology approach identifies a beta-2 adrenergic receptor agonist that causes human tumor regression by blocking the Raf-1/Mek-1/Erk1/2 pathway. Oncogene 26:26, pages 3777-3788.
Crossref
Z G Goldsmith & D N Dhanasekaran. (2007) G Protein regulation of MAPK networks. Oncogene 26:22, pages 3122-3142.
Crossref
Christian Schmees, Christian Prinz, Tilman Treptau, Roland Rad, Ludger Hengst, Petra Voland, Stefan Bauer, Lena Brenner, Roland M. Schmid & Markus Gerhard. (2007) Inhibition of T-Cell Proliferation by Helicobacter pylori γ-Glutamyl Transpeptidase. Gastroenterology 132:5, pages 1820-1833.
Crossref
Yutaro Obara, Angela M. Horgan & Philip J. S. Stork. (2007) The requirement of Ras and Rap1 for the activation of ERKs by cAMP, PACAP, and KCl in cerebellar granule cells. Journal of Neurochemistry 101:2, pages 470-482.
Crossref
Graeme O’Boyle, John G. Brain, John A. Kirby & Simi Ali. (2007) Chemokine-mediated inflammation: Identification of a possible regulatory role for CCR2. Molecular Immunology 44:8, pages 1944-1953.
Crossref
Douglas Tilley & Donald Maurice. 2006. Cyclic Nucleotide Phosphodiesterases in Health and Disease. Cyclic Nucleotide Phosphodiesterases in Health and Disease.
Young-Ho Ahn, Jee Hae Han & Seung Hwan Hong. (2006) Rap1 and p38 MAPK mediate 8-chloro-cAMP-induced growth inhibition in mouse fibroblast DT cells. Journal of Cellular Physiology 209:3, pages 1039-1045.
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Patrick Michl, Beate Knobel & Julian Downward. (2006) CUTL1 Is Phosphorylated by Protein Kinase A, Modulating Its Effects on Cell Proliferation and Motility. Journal of Biological Chemistry 281:22, pages 15138-15144.
Crossref
Dehong Yang, Jun Guo, Paola Divieti & F. Richard Bringhurst. (2006) Parathyroid hormone activates PKC-δ and regulates osteoblastic differentiation via a PLC-independent pathway. Bone 38:4, pages 485-496.
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Federico Monczor, Natalia Fernandez, Eugenia Riveiro, Alejandro Mladovan, Alberto Baldi, Carina Shayo & Carlos Davio. (2006) Histamine H2 receptor overexpression induces U937 cell differentiation despite triggered mechanisms to attenuate cAMP signalling. Biochemical Pharmacology 71:8, pages 1219-1228.
Crossref
Jing Zhao, Xun Zhang, Yunli Zhou, Peter J. Ansell & Anne Klibanski. (2006) Cyclic AMP stimulates MEG3 gene expression in cells through a cAMP-response element (CRE) in the MEG3 proximal promoter region. The International Journal of Biochemistry & Cell Biology 38:10, pages 1808-1820.
Crossref
Esther Lafuente & Vassiliki A. Boussiotis. 2006. Regulators and Effectors of Small GTPases: Ras Family. Regulators and Effectors of Small GTPases: Ras Family 345 358 .
Jean De Gunzburg. 2006. RAS Family GTPases. RAS Family GTPases 295 339 .
Philip J. S. StorkTara J. Dillon. (2005) Multiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functions. Blood 106:9, pages 2952-2961.
Crossref
Nuria Palacios, Franco Sanchez-Franco, Miriam Fernandez, Isabel Sanchez & Lucinda Cacicedo. (2005) Intracellular events mediating insulin-like growth factor I-induced oligodendrocyte development: modulation by cyclic AMP. Journal of Neurochemistry 95:4, pages 1091-1107.
Crossref
Uma K. Misra & Salvatore V. Pizzo. (2005) Coordinate Regulation of Forskolin-induced Cellular Proliferation in Macrophages by Protein Kinase A/cAMP-response Element-binding Protein (CREB) and Epac1-Rap1 Signaling. Journal of Biological Chemistry 280:46, pages 38276-38289.
Crossref
Marit Pedersen Delghandi, Mona Johannessen & Ugo Moens. (2005) The cAMP signalling pathway activates CREB through PKA, p38 and MSK1 in NIH 3T3 cells. Cellular Signalling 17:11, pages 1343-1351.
Crossref
Nicolas Dumaz & Richard Marais. (2005) Integrating signals between cAMP and the RAS/RAF/MEK/ERK signalling pathways. Based on The Anniversary Prize of the Gesellschaft fur Biochemie und Molekularbiologie Lecture delivered on 5 July 2003 at the Special FEBS Meeting in Brussels. FEBS Journal 272:14, pages 3491-3504.
Crossref
Young-Ho Ahn, Joong Mok Jung & Seung Hwan Hong. (2005) 8-Chloro-Cyclic AMP–Induced Growth Inhibition and Apoptosis Is Mediated by p38 Mitogen-Activated Protein Kinase Activation in HL60 Cells. Cancer Research 65:11, pages 4896-4901.
Crossref
Leonidas C. Platanias. (2005) Mechanisms of type-I- and type-II-interferon-mediated signalling. Nature Reviews Immunology 5:5, pages 375-386.
Crossref
Shoji Kimura & Youichi Abe. (2005) . Folia Pharmacologica Japonica 126:4, pages 251-255.
Crossref
Fernando Ribeiro-Neto, Angelica Leon, Julie Urbani-Brocard, Liguang Lou, Abraham Nyska & Daniel L. Altschuler. (2004) cAMP-dependent Oncogenic Action of Rap1b in the Thyroid Gland. Journal of Biological Chemistry 279:45, pages 46868-46875.
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Fuminori Taniguchi, Tasuku Harada, Imari Deura, Tomio Iwabe, Satoru Tsukihara & Naoki Terakawa. (2004) Hepatocyte growth factor promotes cell proliferation and inhibits progesterone secretion via PKA and MAPK pathways in a human granulosa cell line. Molecular Reproduction and Development 68:3, pages 335-344.
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Changbin Chen, Arye Harel, Rena Gorovoits, Oded Yarden & Martin B. Dickman. (2004) MAPK Regulation of Sclerotial Development in Sclerotinia sclerotiorum Is Linked with pH and cAMP Sensing . Molecular Plant-Microbe Interactions® 17:4, pages 404-413.
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Jacques T Weissman, Jian-Nong Ma, Anthony Essex, Yan Gao & Ethan S Burstein. (2004) G-protein-coupled receptor-mediated activation of rap GTPases: characterization of a novel Gαi regulated pathway. Oncogene 23:1, pages 241-249.
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Juan F. Santibáñez, Daniela Olivares, Javier Guerrero & Jorge Martínez. (2003) Cyclic AMP inhibits TGFβ1-induced cell-scattering and invasiveness in murine-transformed keratinocytes. International Journal of Cancer 107:5, pages 715-720.
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Suck-Chei Choi, Bum-Su Kim, Moon-Young Song, Eun-Young Choi, Hyun-Mee Oh, June-Hyung Lyou, Weon-Cheol Han, Hyung-Bae Moon, Tae-Hyeon Kim, Jae-Min Oh, Hun-Taeg Chung & Chang-Duk Jun. (2003) Downregulation of p38 kinase pathway by cAMP response element-binding protein protects HL-60 cells from iron chelator-induced apoptosis. Free Radical Biology and Medicine 35:10, pages 1171-1184.
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Antonio Porcellini, Samantha Messina, Giorgia De Gregorio, Antonio Feliciello, Annalisa Carlucci, Mariavittoria Barone, Antonietta Picascia, Antonio De Blasi & Enrico V. Avvedimento. (2003) The Expression of the Thyroid-stimulating Hormone (TSH) Receptor and the cAMP-dependent Protein Kinase RII β Regulatory Subunit Confers TSH-cAMP-dependent Growth to Mouse Fibroblasts. Journal of Biological Chemistry 278:42, pages 40621-40630.
Crossref
Raj S Mitra, Zhaocheng Zhang, Bradley S Henson, David M Kurnit, Thomas E Carey & Nisha J D'Silva. (2003) Rap1A and rap1B ras-family proteins are prominently expressed in the nucleus of squamous carcinomas: nuclear translocation of GTP-bound active form. Oncogene 22:40, pages 6243-6256.
Crossref
Geraldine Ferjoux, Frederic Lopez, Jean-Pierre Esteve, Audrey Ferrand, Eric Vivier, Frederic Vely, Nathalie Saint-Laurent, Lucien Pradayrol, Louis Buscail & Christiane Susini. (2003) Critical Role of Src and SHP-2 in sst2 Somatostatin Receptor-mediated Activation of SHP-1 and Inhibition of Cell Proliferation. Molecular Biology of the Cell 14:9, pages 3911-3928.
Crossref
N.J. D'Silva, R.S. Mitra, Z. Zhang, D.M. Kurnit, C.R. Babcock, P.J. Polverini & T.E. Carey. (2003) Rap1, a small GTP-binding protein is upregulated during arrest of proliferation in human keratinocytes. Journal of Cellular Physiology 196:3, pages 532-540.
Crossref
Pavlos Pissios, Daniel J. Trombly, Iphigenia Tzameli & Eleftheria Maratos-Flier. (2003) Melanin-Concentrating Hormone Receptor 1 Activates Extracellular Signal-Regulated Kinase and Synergizes with Gs-Coupled Pathways. Endocrinology 144:8, pages 3514-3523.
Crossref
Kishalay Hoare, Sarasija Hoare, Orla M Smith, Grace Kalmaz, Donald Small & W Stratford MayJrJr. (2003) Kos1, a nonreceptor tyrosine kinase that suppresses Ras signaling. Oncogene 22:23, pages 3562-3577.
Crossref
Philip J.S. Stork. (2003) Does Rap1 deserve a bad Rap?. Trends in Biochemical Sciences 28:5, pages 267-275.
Crossref
Ye Zhang, Yi Luo, Qiwei Zhai, Liying Ma & Martin E. Dorf. (2003) Negative role of cAMP‐dependent protein kinase A in RANTES‐mediated transcription of proinflammatory mediators through Raf. The FASEB Journal 17:6, pages 734-736.
Crossref
Leonard J. Appleman & Vassiliki A. Boussiotis. (2003) T cell anergy and costimulation. Immunological Reviews 192:1, pages 161-180.
Crossref
Emmanuelle Caron. (2003) Cellular functions of the Rap1 GTP-binding protein: a pattern emerges. Journal of Cell Science 116:3, pages 435-440.
Crossref
Thomas Grader-BeckAndre A. F. L. van PuijenbroekLee M. NadlerVassiliki A. Boussiotis. (2003) cAMP inhibits both Ras and Rap1 activation in primary human T lymphocytes, but only Ras inhibition correlates with blockade of cell cycle progression. Blood 101:3, pages 998-1006.
Crossref
Louis Gendron, Jean-François Oligny, Marcel Daniel Payet & Nicole Gallo-Payet. (2003) Cyclic AMP-independent Involvement of Rap1/B-Raf in the Angiotensin II AT2 Receptor Signaling Pathway in NG108-15 Cells. Journal of Biological Chemistry 278:6, pages 3606-3614.
Crossref
Kendall D. Carey, Robert T. Watson, Jeffrey E. Pessin & Philip J.S. Stork. (2003) The Requirement of Specific Membrane Domains for Raf-1 Phosphorylation and Activation. Journal of Biological Chemistry 278:5, pages 3185-3196.
Crossref
Edith Gomez, Catrin Pritchard & Terence P. Herbert. (2002) cAMP-dependent Protein Kinase and Ca2+Influx through L-type Voltage-gated Calcium Channels Mediate Raf-independent Activation of Extracellular Regulated Kinase in Response to Glucagon-like Peptide-1 in Pancreatic β-Cells. Journal of Biological Chemistry 277:50, pages 48146-48151.
Crossref
Kou-Juey Wu, Michela Mattioli, Herbert C MorseIIIIII & Riccardo Dalla-Favera. (2002) c-MYC activates protein kinase A (PKA) by direct transcriptional activation of the PKA catalytic subunit beta (PKA-Cβ) gene. Oncogene 21:51, pages 7872-7882.
Crossref
Jingwei Meng & Patrick J. Casey. (2002) Activation of Gz Attenuates Rap1-mediated Differentiation of PC12 Cells. Journal of Biological Chemistry 277:45, pages 43417-43424.
Crossref
John M. Schmitt & Philip J.S. Stork. (2002) Gα and Gβγ Require Distinct Src-dependent Pathways to Activate Rap1 and Ras. Journal of Biological Chemistry 277:45, pages 43024-43032.
Crossref
Christiane Hecquet, Gaëlle Lefevre, Monika Valtink, Katrin Engelmann & Frederic Mascarelli. (2002) cAMP inhibits the proliferation of retinal pigmented epithelial cells through the inhibition of ERK1/2 in a PKA-independent manner. Oncogene 21:39, pages 6101-6112.
Crossref
Liguang Lou, Julie Urbani, Fernando Ribeiro-Neto & Daniel L. Altschuler. (2002) cAMP Inhibition of Akt Is Mediated by Activated and Phosphorylated Rap1b. Journal of Biological Chemistry 277:36, pages 32799-32806.
Crossref
Susan F. Steinberg. (2002) Focus on “Targeted expression of activated Q227L Gα s in vivo” . American Journal of Physiology-Cell Physiology 283:2, pages C383-C385.
Crossref
Amardeep S Dhillon & Walter Kolch. (2002) Untying the regulation of the Raf-1 kinase. Archives of Biochemistry and Biophysics 404:1, pages 3-9.
Crossref
Philip J.S Stork & John M Schmitt. (2002) Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation. Trends in Cell Biology 12:6, pages 258-266.
Crossref
Fernando Ribeiro-Neto, Julie Urbani, Nicolas Lemee, Liguang Lou & Daniel L. Altschuler. (2002) On the mitogenic properties of Rap1b: cAMP-induced G 1 /S entry requires activated and phosphorylated Rap1b . Proceedings of the National Academy of Sciences 99:8, pages 5418-5423.
Crossref
Toshiki Nishio, Masakazu Haneda, Daisuke Koya, Ken Inoki, Shiro Maeda & Ryuichi Kikkawa. (2002) Cyclic AMP inhibits stretch-induced overexpression of fibronectin in glomerular mesangial cells. European Journal of Pharmacology 437:3, pages 113-122.
Crossref
Arturo P Saavedra, Oxana M Tsygankova, Gregory V Prendergast, Jessica H Dworet, Guanjun Cheng & Judy L Meinkoth. (2002) Role of cAMP, PKA and Rap1A in thyroid follicular cell survival. Oncogene 21:5, pages 778-788.
Crossref
John M Schmitt & Philip J.S Stork. (2002) PKA Phosphorylation of Src Mediates cAMP's Inhibition of Cell Growth via Rap1. Molecular Cell 9:1, pages 85-94.
Crossref
Matthew L. Edin, Alan K. Howe & Rudy L. Juliano. (2001) Inhibition of PKA Blocks Fibroblast Migration in Response to Growth Factors. Experimental Cell Research 270:2, pages 214-222.
Crossref
Lai Wang, Feng Liu & Martin L. Adamo. (2001) Cyclic AMP Inhibits Extracellular Signal-regulated Kinase and Phosphatidylinositol 3-Kinase/Akt Pathways by Inhibiting Rap1. Journal of Biological Chemistry 276:40, pages 37242-37249.
Crossref

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