64
Views
211
CrossRef citations to date
0
Altmetric
Cell Growth and Development

The MLK Family Mediates c-Jun N-Terminal Kinase Activation in Neuronal Apoptosis

, , , &
Pages 4713-4724 | Received 09 Apr 2001, Accepted 16 Apr 2001, Published online: 28 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

Srimathi Kasturirangan, Batool Mehdi & Deborah N. Chadee. (2021) LATS1 Regulates Mixed-Lineage Kinase 3 (MLK3) Subcellular Localization and MLK3-Mediated Invasion in Ovarian Epithelial Cells. Molecular and Cellular Biology 41:7.
Read now
Elke Oetjen & Thomas Lemcke. (2016) Dual leucine zipper kinase (MAP3K12) modulators: a patent review (2010–2015). Expert Opinion on Therapeutic Patents 26:5, pages 607-616.
Read now
Natalya A. Blessing, April L. Brockman & Deborah N. Chadee. (2014) The E3 Ligase CHIP Mediates Ubiquitination and Degradation of Mixed-Lineage Kinase 3. Molecular and Cellular Biology 34:16, pages 3132-3143.
Read now
Mikhail V. Shepelev, Jonathan Chernoff & Igor V. Korobko. (2011) Rho family GTPase Chp/RhoV induces PC12 apoptotic cell death via JNK activation. Small GTPases 2:1, pages 17-26.
Read now
Zhiheng Xu, Nikolay V. Kukekov & Lloyd A. Greene. (2005) Regulation of Apoptotic c-Jun N-Terminal Kinase Signaling by a Stabilization-Based Feed-Forward Loop. Molecular and Cellular Biology 25:22, pages 9949-9959.
Read now
Bumnoh Lee & Nam Jeong Cho. (2005) Analysis of the Caenorhabditis elegans dlk‐1 gene expression. Integrative Biosciences 9:3, pages 107-111.
Read now
Dana Perkins, Kymberly A Gyure, Edna FR Pereira & Laure Aurelian. (2003) Herpes Simplex Virus Type 1-Induced Encephalitis has an Apoptotic Component Associated with Activation of c-Jun N-Terminal Kinase. Journal of Neurovirology 9:1, pages 101-111.
Read now

Articles from other publishers (202)

Heba M. Mansour, Ahmed F. Mohamed, Aiman S. El-Khatib & Mahmoud.M. Khattab. (2023) Kinases control of regulated cell death revealing druggable targets for Parkinson’s disease. Ageing Research Reviews 85, pages 101841.
Crossref
Menghua Li, Minyan Guo, Yice Xu, Liyuan Wu, Mengbing Chen, Yanfen Dong, Liting Zheng, Daishi Chen, Yuehua Qiao, Zhaoyang Ke & Xi Shi. (2023) Murine cytomegalovirus employs the mixed lineage kinases family to regulate the spiral ganglion neuron cell death and hearing loss. Neuroscience Letters 793, pages 136990.
Crossref
Elena Tortosa, Arundhati Sengupta Ghosh, Qingling Li, Weng Ruh Wong, Trent Hinkle, Wendy Sandoval, Christopher M Rose & Casper C Hoogenraad. (2022) Stress‐induced vesicular assemblies of dual leucine zipper kinase are signaling hubs involved in kinase activation and neurodegeneration. The EMBO Journal 41:14.
Crossref
Quan Wen, Huandi Weng, Tao Liu, Lingtai Yu, Tianyun Zhao, Jingwen Qin, Si Li, Qingfeng Wu, Fadel Tissir, Yibo Qu & Libing Zhou. (2022) Inactivating Celsr2 promotes motor axon fasciculation and regeneration in mouse and human . Brain 145:2, pages 670-683.
Crossref
Megan Jandy, Asra Noor, Pascal Nelson, Cassandra N. Dennys, Isabella M. Karabinas, Jeanine C. Pestoni, Gautam D. Singh, Lam Luc, Rachel Devyldere, Nathalie Perdomo, Catherine E. Mitchell, Levi Adams, Marisa A. Fuse, Francine A. Mendoza, Carrie L. Marean-Reardon, Ryan A. Mehl, Alvaro G. Estevez & Maria Clara Franco. (2022) Peroxynitrite nitration of Tyr 56 in Hsp90 induces PC12 cell death through P2X7R-dependent PTEN activation. Redox Biology 50, pages 102247.
Crossref
Rajeshwar Kumar Yadav, Elizabeth Minz & Sidharth Mehan. (2021) Understanding Abnormal c-JNK/p38MAPK Signaling in Amyotrophic Lateral Sclerosis: Potential Drug Targets and Influences on Neurological Disorders. CNS & Neurological Disorders - Drug Targets 20:5, pages 417-429.
Crossref
Judith Somekh. (2021) Model-based pathway enrichment analysis applied to the TGF-beta regulation of autophagy in autism. Journal of Biomedical Informatics 118, pages 103781.
Crossref
Sandeep Kumar, Sunil Kumar Singh, Basabi Rana & Ajay Rana. (2021) The regulatory function of mixed lineage kinase 3 in tumor and host immunity. Pharmacology & Therapeutics 219, pages 107704.
Crossref
Yafei Chang, Yisheng Jiang, Cui Li, Qin Wang, Feng Zhang, Cheng-Feng Qin, Qing-Feng Wu, Jing Li & Zhiheng Xu. (2020) Different Gene Networks Are Disturbed by Zika Virus Infection in A Mouse Microcephaly Model. Genomics, Proteomics & Bioinformatics 18:6, pages 737-748.
Crossref
Sunil Goodwani, Celia Fernandez, Paul J. Acton, Virginie Buggia-Prevot, Morgan L. McReynolds, Jiacheng Ma, Cheng Hui Hu, Mary E. Hamby, Yongying Jiang, Kang Le, Michael J. Soth, Philip Jones & William J. Ray. (2020) Dual Leucine Zipper Kinase Is Constitutively Active in the Adult Mouse Brain and Has Both Stress-Induced and Homeostatic Functions. International Journal of Molecular Sciences 21:14, pages 4849.
Crossref
Yuhan Liu, Jinxing Hou, Meng Zhang, Emeline Seleh‐Zo, Jiangang Wang, Binyun Cao & Xiaopeng An. (2019) circ‐016910 sponges miR‐574‐5p to regulate cell physiology and milk synthesis via MAPK and PI3K/AKT–mTOR pathways in GMECs. Journal of Cellular Physiology 235:5, pages 4198-4216.
Crossref
Mary Pitman, Daniël P. Melters & Yamini Dalal. (2020) Job Opening for Nucleosome Mechanic: Flexibility Required. Cells 9:3, pages 580.
Crossref
Emilie Hollville, Selena E. Romero & Mohanish Deshmukh. (2019) Apoptotic cell death regulation in neurons. The FEBS Journal 286:17, pages 3276-3298.
Crossref
Guiping Wang, David J Simon, Zhuhao Wu, Deanna M Belsky, Evan Heller, Melanie K O'Rourke, Nicholas T Hertz, Henrik Molina, Guisheng Zhong, Marc Tessier-Lavigne & Xiaowei Zhuang. (2019) Structural plasticity of actin-spectrin membrane skeleton and functional role of actin and spectrin in axon degeneration. eLife 8.
Crossref
Masato Ogura, Haruhisa Kikuchi, Norshalena Shakespear, Toshiyuki Suzuki, Junko Yamaki, Miwako K. Homma, Yoshiteru Oshima & Yoshimi Homma. (2019) Prenylated quinolinecarboxylic acid derivative prevents neuronal cell death through inhibition of MKK4. Biochemical Pharmacology 162, pages 109-122.
Crossref
Priyanka Saminathan, Bhavesh D. Kevadiya, Daniel F. Marker, Howard E. Gendelman, Santhi Gorantla & Harris A. Gelbard. (2019) Broad Spectrum Mixed Lineage Kinase Type 3 Inhibition and HIV-1 Persistence in Macrophages. Journal of Neuroimmune Pharmacology 14:1, pages 44-51.
Crossref
Matthew J. Geden, Selena E. Romero & Mohanish Deshmukh. (2019) Apoptosis versus axon pruning: Molecular intersection of two distinct pathways for axon degeneration. Neuroscience Research 139, pages 3-8.
Crossref
Toshiyuki Araki & Shuji Wakatsuki. (2019) Regulation of neuronal/axonal degeneration by ZNRF1 ubiquitin ligase. Neuroscience Research 139, pages 21-25.
Crossref
Tomomi Kiyota, Jatin Machhi, Yaman Lu, Bhagyalaxmi Dyavarshetty, Maryam Nemati, Gang Zhang, R. Lee Mosley, Harris A. Gelbard & Howard E. Gendelman. (2018) URMC-099 facilitates amyloid-β clearance in a murine model of Alzheimer’s disease. Journal of Neuroinflammation 15:1.
Crossref
Matthew J. Bellizzi, Jennetta W. Hammond, Herman Li, Mary A. Gantz Marker, Daniel F. Marker, Robert S. Freeman & Harris A. Gelbard. (2018) The Mixed-Lineage Kinase Inhibitor URMC-099 Protects Hippocampal Synapses in Experimental Autoimmune Encephalomyelitis. eneuro 5:6, pages ENEURO.0245-18.2018.
Crossref
Zhe Ying, Madeline Sandoval & Slobodan Beronja. (2018) Oncogenic activation of PI3K induces progenitor cell differentiation to suppress epidermal growth. Nature Cell Biology 20:11, pages 1256-1266.
Crossref
Shiqing Li, Tao Zhang, Xiaoqing Zhou, Zonghan Du, Fumin Chen, Jun Luo & Qingsong Liu. (2018) The tumor suppressor role of miR‑155‑5p in gastric cancer. Oncology Letters.
Crossref
Kyle J. Burghardt, Jacyln M. Goodrich, Brittany N. Lines & Vicki L. Ellingrod. (2018) The Influence of Metabolic Syndrome and Sex on the DNA Methylome in Schizophrenia. International Journal of Genomics 2018, pages 1-12.
Crossref
Richard Blouin. 2018. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 1397 1402 .
Cheng Yin, Guang-fu Huang, Xiao-chuan Sun, Zongduo Guo & John H. Zhang. (2017) DLK silencing attenuated neuron apoptosis through JIP3/MA2K7/JNK pathway in early brain injury after SAH in rats. Neurobiology of Disease 103, pages 133-143.
Crossref
Qing Liu, Qin Wang, Weixian Deng, Xu Wang, Mingxin Piao, Dawei Cai, Yaxing Li, William D. Barshop, Xiaolan Yu, Tingting Zhou, Bin Liu, Yoshito Oka, James Wohlschlegel, Zecheng Zuo & Chentao Lin. (2017) Molecular basis for blue light-dependent phosphorylation of Arabidopsis cryptochrome 2. Nature Communications 8:1.
Crossref
Bin Jiang, Jia Zhang, Jinmei Xia, Wentao Zhao, Yanan Wu, Minggang Shi, Lianzhong Luo, Huamin Zhou, Ai Chen, Huanhuan Ma, Qingwen Zhao, Muhammad Suleman, Furong Lin, Lin Zhou, Jinyang Wang, Yan Zhang, Ying He, Xiaotong Li, Li-Man Hung, Tak Wah Mak & Qinxi Li. (2017) IDH1 Mutation Promotes Tumorigenesis by Inhibiting JNK Activation and Apoptosis Induced by Serum Starvation. Cell Reports 19:2, pages 389-400.
Crossref
Anindyasundar Adak, Gaurav Das, Surajit Barman, Saswat Mohapatra, Debmalya Bhunia, Batakrishna Jana & Surajit Ghosh. (2017) Biodegradable Neuro-Compatible Peptide Hydrogel Promotes Neurite Outgrowth, Shows Significant Neuroprotection, and Delivers Anti-Alzheimer Drug. ACS Applied Materials & Interfaces 9:6, pages 5067-5076.
Crossref
Nandini Chatterjee, Priyankar Sanphui, Stav Kemeny, Lloyd A Greene & Subhas C Biswas. (2016) Role and regulation of Cdc25A phosphatase in neuron death induced by NGF deprivation or β-amyloid. Cell Death Discovery 2:1.
Crossref
Kenneth D'Souza, Carine Nzirorera & Petra C. Kienesberger. (2016) Lipid metabolism and signaling in cardiac lipotoxicity. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1861:10, pages 1513-1524.
Crossref
Syed Mehdi, Hector Rosas-Hernandez, Elvis Cuevas, Susan Lantz, Steven Barger, Sumit Sarkar, Merle Paule, Syed Ali & Syed Imam. (2016) Protein Kinases and Parkinson’s Disease. International Journal of Molecular Sciences 17:9, pages 1585.
Crossref
Siobhan M. Craige, Michaella M. Reif & Shashi Kant. (2016) Mixed – Lineage Protein kinases (MLKs) in inflammation, metabolism, and other disease states. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1862:9, pages 1581-1586.
Crossref
Matthew J Geden & Mohanish Deshmukh. (2016) Axon degeneration: context defines distinct pathways. Current Opinion in Neurobiology 39, pages 108-115.
Crossref
Elke Oetjen. (2016) Regulation of Beta-Cell Function and Mass by the Dual Leucine Zipper Kinase. Archiv der Pharmazie 349:6, pages 410-413.
Crossref
Feng Zhang, Jingwen Yu, Tao Yang, Dan Xu, Zhixia Chi, Yanheng Xia & Zhiheng Xu. (2016) A Novel c-Jun N-terminal Kinase (JNK) Signaling Complex Involved in Neuronal Migration during Brain Development. Journal of Biological Chemistry 291:22, pages 11466-11475.
Crossref
Manuel Wallbach, Jorge Duque Escobar, Rohollah Babaeikelishomi, Marie-Jeannette Stahnke, Roland Blume, Sabine Schröder, Jenny Kruegel, Kathrin Maedler, Oliver Kluth, Ralph H. Kehlenbach, Nicolai Miosge & Elke Oetjen. (2016) Distinct functions of the dual leucine zipper kinase depending on its subcellular localization. Cellular Signalling 28:4, pages 272-283.
Crossref
Richard Blouin. 2016. Encyclopedia of Signaling Molecules. Encyclopedia of Signaling Molecules 1 6 .
Atanu Biswas, Prashant Kurkute, Suraiya Saleem, Batakrishna Jana, Saswat Mohapatra, Prasenjit Mondal, Anindyasundar Adak, Subhajit Ghosh, Abhijit Saha, Debmalya Bhunia, Subhash Chandra Biswas & Surajit Ghosh. (2015) Novel Hexapeptide Interacts with Tubulin and Microtubules, Inhibits Aβ Fibrillation, and Shows Significant Neuroprotection. ACS Chemical Neuroscience 6:8, pages 1309-1316.
Crossref
HUA-FU ZHAO, JING WANG & SHING-SHUN TONY TO. (2015) The phosphatidylinositol 3-kinase/Akt and c-Jun N-terminal kinase signaling in cancer: Alliance or contradiction? (Review). International Journal of Oncology 47:2, pages 429-436.
Crossref
Goran Marinković, Anouk A. J. Hamers, Carlie J. M. de Vries & Vivian de Waard. (2014) 6-Mercaptopurine Reduces Macrophage Activation and Gut Epithelium Proliferation Through Inhibition of GTPase Rac1. Inflammatory Bowel Diseases 20:9, pages 1487-1495.
Crossref
Marie-Jeannette Stahnke, Corinna Dickel, Sabine Schröder, Diana Kaiser, Roland Blume, Roland Stein, Celio Pouponnot & Elke Oetjen. (2014) Inhibition of human insulin gene transcription and MafA transcriptional activity by the dual leucine zipper kinase. Cellular Signalling 26:9, pages 1792-1799.
Crossref
Hong-Dong Li, Rajasree Menon, Gilbert S. Omenn & Yuanfang Guan. (2014) The emerging era of genomic data integration for analyzing splice isoform function. Trends in Genetics 30:8, pages 340-347.
Crossref
M Kristiansen & J Ham. (2014) Programmed cell death during neuronal development: the sympathetic neuron model. Cell Death & Differentiation 21:7, pages 1025-1035.
Crossref
Jiyoung Moon & Sang-Hyun Park. (2014) Reassembly of JIP1 Scaffold Complex in JNK MAP Kinase Pathway Using Heterologous Protein Interactions. PLoS ONE 9:5, pages e96797.
Crossref
Goran Marinković, Jeffrey Kroon, Mark Hoogenboezem, Kees A. Hoeben, Matthijs S. Ruiter, Kondababu Kurakula, Iker Otermin Rubio, Mariska Vos, Carlie J. M. de Vries, Jaap D. van Buul & Vivian de Waard. (2014) Inhibition of GTPase Rac1 in Endothelium by 6-Mercaptopurine Results in Immunosuppression in Nonimmune Cells: New Target for an Old Drug. The Journal of Immunology 192:9, pages 4370-4378.
Crossref
Guixin Zhu, Zhongyun Fan, Miao Ding, Libing Mu, Juan Liang, Yajie Ding, Yu Fu, Binlu Huang & Wei Wu. (2014) DNA Damage Induces the Accumulation of Tiam1 by Blocking β-TrCP-dependent Degradation. Journal of Biological Chemistry 289:22, pages 15482-15494.
Crossref
Oksana Polesskaya, Christopher Wong, Luis Lebron, Jeffrey M. Chamberlain, Harris A. Gelbard, Val Goodfellow, Minsoo Kim, John L. Daiss & Stephen Dewhurst. (2014) MLK3 regulates fMLP-stimulated neutrophil motility. Molecular Immunology 58:2, pages 214-222.
Crossref
Samar H. Ibrahim, Gregory J. Gores, Petra Hirsova, Michelle Kirby, Lili Miles, Anja Jaeschke & Rohit Kohli. (2014) Mixed lineage kinase 3 deficient mice are protected against the high fat high carbohydrate diet-induced steatohepatitis. Liver International 34:3, pages 427-437.
Crossref
Ida Rishal & Mike Fainzilber. (2013) Axon–soma communication in neuronal injury. Nature Reviews Neuroscience 15:1, pages 32-42.
Crossref
Daniel F. Marker, Shao-Ming Lu & Harris A. Gelbard. 2014. Microglia in Health and Disease. Microglia in Health and Disease 373 392 .
Corey L. Cusack, Ryan P. Annis, Adam J. Kole & Mohanish Deshmukh. 2014. Cell Death. Cell Death 167 188 .
Sehamuddin Galadari, Anees Rahman, Siraj Pallichankandy, Alaa Galadari & Faisal Thayyullathil. (2013) Role of ceramide in diabetes mellitus: evidence and mechanisms. Lipids in Health and Disease 12:1.
Crossref
Ying Y. JeanElena M. RibeMaria Elena Pero, Marina MoskalenkoZarah IqbalLianna J. MarksLloyd A. GreeneCarol M. Troy. (2013) Caspase-2 is essential for c-Jun transcriptional activation and Bim induction in neuron death. Biochemical Journal 455:1, pages 15-25.
Crossref
Sarah Huntwork-Rodriguez, Bei Wang, Trent Watkins, Arundhati Sengupta Ghosh, Christine D. Pozniak, Daisy Bustos, Kim Newton, Donald S. Kirkpatrick & Joseph W. Lewcock. (2013) JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis. Journal of Cell Biology 202:5, pages 747-763.
Crossref
Yuangang Zhu, Chunyan Wang, Mei Yu, Jie Cui, Liang Liu & Zhiheng Xu. (2013) ULK1 and JNK are involved in mitophagy incurred by LRRK2 G2019S expression. Protein & Cell 4:9, pages 711-721.
Crossref
A J Kole, R P Annis & M Deshmukh. (2013) Mature neurons: equipped for survival. Cell Death & Disease 4:6, pages e689-e689.
Crossref
Deborah N. Chadee. (2013) Involvement of mixed lineage kinase 3 in cancer. Canadian Journal of Physiology and Pharmacology 91:4, pages 268-274.
Crossref
Yong An, Baobao Cai, Jianmin Chen, Nan Lv, Jie Yao, Xiaofeng Xue, Min Tu, Dong Tang, Jishu Wei, Kuirong Jiang, Junli Wu, Qiang Li, Wentao Gao & Yi Miao. (2013) MAP3K10 promotes the proliferation and decreases the sensitivity of pancreatic cancer cells to gemcitabine by upregulating Gli-1 and Gli-2. Cancer Letters 329:2, pages 228-235.
Crossref
Pavlo L. KovalenkoLyudmyla KunovskaJian ChenKathleen A. Gallo & Marc D. Basson. (2012) Loss of MLK3 signaling impedes ulcer healing by modulating MAPK signaling in mouse intestinal mucosa. American Journal of Physiology-Gastrointestinal and Liver Physiology 303:8, pages G951-G960.
Crossref
Jingwen Niu, Mei Yu, Chunyan Wang & Zhiheng Xu. (2012) Leucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like protein. Journal of Neurochemistry 122:3, pages 650-658.
Crossref
Shujing Liu, Michael T Tetzlaff, Aihua Liu, Bernadette Liegl-Atzwanger, Jun Guo & Xiaowei Xu. (2012) Loss of microRNA-205 expression is associated with melanoma progression. Laboratory Investigation 92:7, pages 1084-1096.
Crossref
Mitchell S Stark, Susan L Woods, Michael G Gartside, Vanessa F Bonazzi, Ken Dutton-Regester, Lauren G Aoude, Donald Chow, Chris Sereduk, Natalie M Niemi, Nanyun Tang, Jonathan J Ellis, Jeffrey Reid, Victoria Zismann, Sonika Tyagi, Donna Muzny, Irene Newsham, YuanQing Wu, Jane M Palmer, Thomas Pollak, David Youngkin, Bradford R Brooks, Catherine Lanagan, Christopher W Schmidt, Bostjan Kobe, Jeffrey P MacKeigan, Hongwei Yin, Kevin M Brown, Richard Gibbs, Jeffrey Trent & Nicholas K Hayward. (2011) Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing. Nature Genetics 44:2, pages 165-169.
Crossref
Alim Seit-Nebi, Wei Cheng, Hong Xu & Jiahuai Han. (2011) MLK4 has negative effect on TLR4 signaling. Cellular & Molecular Immunology 9:1, pages 27-33.
Crossref
Manju Sharma, Fumihiko Urano & Anja Jaeschke. (2012) Cdc42 and Rac1 are major contributors to the saturated fatty acid-stimulated JNK pathway in hepatocytes. Journal of Hepatology 56:1, pages 192-198.
Crossref
Shujing Liu, Suresh M Kumar, Hezhe Lu, Aihua Liu, Ruifeng Yang, Anitha Pushparajan, Wei Guo & Xiaowei Xu. (2012) MicroRNA-9 up-regulates E-cadherin through inhibition of NF-κB1-Snail1 pathway in melanoma. The Journal of Pathology 226:1, pages 61-72.
Crossref
Mark Kristiansen, Francesca Menghi, Rosie Hughes, Mike Hubank & Jonathan Ham. (2011) Global analysis of gene expression in NGF-deprived sympathetic neurons identifies molecular pathways associated with cell death. BMC Genomics 12:1.
Crossref
Jung Eun Shin & Aaron DiAntonio. (2011) Highwire Regulates Guidance of Sister Axons in the Drosophila Mushroom Body . The Journal of Neuroscience 31:48, pages 17689-17700.
Crossref
Rebecca A. Scott, Donald L. Elbert & Rebecca Kuntz Willits. (2011) Modular poly(ethylene glycol) scaffolds provide the ability to decouple the effects of stiffness and protein concentration on PC12 cells. Acta Biomaterialia 7:11, pages 3841-3849.
Crossref
Jie Cui, Mei Yu, Jingwen Niu, Zhenyu YueZhiheng Xu. (2011) Expression of leucine-rich repeat kinase 2 (LRRK2) inhibits the processing of uMtCK to induce cell death in a cell culture model system. Bioscience Reports 31:5, pages 429-437.
Crossref
Anett Jandke, Clive Da Costa, Rocio Sancho, Emma Nye, Bradley Spencer-Dene & Axel Behrens. (2011) The F-box protein Fbw7 is required for cerebellar development. Developmental Biology 358:1, pages 201-212.
Crossref
Arundhati Sengupta Ghosh, Bei Wang, Christine D. Pozniak, Mark Chen, Ryan J. Watts & Joseph W. Lewcock. (2011) DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity. Journal of Cell Biology 194:5, pages 751-764.
Crossref
Alex Daviau, Jean-Philippe Couture & Richard Blouin. (2011) Loss of DLK expression in WI-38 human diploid fibroblasts induces a senescent-like proliferation arrest. Biochemical and Biophysical Research Communications 413:2, pages 282-287.
Crossref
Kohsuke TakedaIsao NaguroHideki NishitohAtsushi MatsuzawaHidenori Ichijo. (2011) Apoptosis Signaling Kinases: From Stress Response to Health Outcomes. Antioxidants & Redox Signaling 15:3, pages 719-761.
Crossref
Grazyna Niewiadomska, Anna Mietelska-Porowska & Marcin Mazurkiewicz. (2011) The cholinergic system, nerve growth factor and the cytoskeleton. Behavioural Brain Research 221:2, pages 515-526.
Crossref
Aki Itoh, Makoto Horiuchi, Kouji Wakayama, Jie Xu, Peter Bannerman, David Pleasure & Takayuki Itoh. (2011) ZPK/DLK, a Mitogen-Activated Protein Kinase Kinase Kinase, Is a Critical Mediator of Programmed Cell Death of Motoneurons. The Journal of Neuroscience 31:20, pages 7223-7228.
Crossref
Ryan T. Willett & Lloyd A. Greene. (2011) Gata2 Is Required for Migration and Differentiation of Retinorecipient Neurons in the Superior Colliculus. The Journal of Neuroscience 31:12, pages 4444-4455.
Crossref
Do Thanh Phu, Manuel Wallbach, Chantal Depatie, Accalia Fu, Robert A. Screaton & Elke Oetjen. (2011) Regulation of the CREB coactivator TORC by the dual leucine zipper kinase at different levels. Cellular Signalling 23:2, pages 344-353.
Crossref
Vladimir I. KashubaElvira V. GrigorievaSergei M. KvashaTatiana V. PavlovaVladimir GrigorievAlexei ProtopopovOlga KharchenkoRinat GizatullinAlla V. RynditchEugene R. Zabarovsky. (2011) Cloning and Initial Functional Characterization of Mlk4α and Mlk4β. Genomics Insights 4, pages GEI.S6092.
Crossref
Oksana Polesskaya, Lisa L. Cunningham, Shimon P. Francis, Anne E. Luebke, Xiaoxia Zhu, David Collins, Olga N. Vasilyeva, Julie Sahler, Emily A. Desmet, Harris A. Gelbard, Sanjay B. Maggirwar, Joseph P. Walton, Robert D. FrisinaJr.Jr. & Stephen Dewhurst. (2010) Ablation of mixed lineage kinase 3 (Mlk3) does not inhibit ototoxicity induced by acoustic trauma or aminoglycoside exposure. Hearing Research 270:1-2, pages 21-27.
Crossref
Ajay Rana, Velusamy Rangasamy & Rajakishore Mishra. (2010) How estrogen fuels breast cancer. Future Oncology 6:9, pages 1369-1371.
Crossref
Chunyan Wang, Yang Tao, Yaqing Wang & Zhiheng Xu. (2010) Regulation of the protein stability of POSH and MLK family. Protein & Cell 1:9, pages 871-878.
Crossref
Xian-Jue MA & Lei XUE. (2010) Regulation of the JNK signaling pathway by dual leucine zipper kinase DLK. Hereditas (Beijing) 32:8, pages 785-790.
Crossref
Mark Kristiansen, Rosie Hughes, Pritika Patel, Thomas S. Jacques, Andrew R. Clark & Jonathan Ham. (2010) Mkp1 Is a c-Jun Target Gene That Antagonizes JNK-Dependent Apoptosis in Sympathetic Neurons . The Journal of Neuroscience 30:32, pages 10820-10832.
Crossref
Rohan K. Humphrey, Christina J. Newcomb, Shu-Mei A. Yu, Ergeng Hao, Doris Yu, Stan Krajewski, Keyong Du & Ulupi S. Jhala. (2010) Mixed Lineage Kinase-3 Stabilizes and Functionally Cooperates with TRIBBLES-3 to Compromise Mitochondrial Integrity in Cytokine-induced Death of Pancreatic Beta Cells. Journal of Biological Chemistry 285:29, pages 22426-22436.
Crossref
Geou-Yarh LiouHua ZhangEva M. MillerSteve A. SeiboldWeiqin ChenKathleen A. Gallo. (2010) Induced, selective proteolysis of MLK3 negatively regulates MLK3/JNK signalling. Biochemical Journal 427:3, pages 435-443.
Crossref
Emily A. Desmet, Joseph A. Hollenbaugh, Patricia J. Sime, Terry W. Wright, David J. Topham, Andrea J. Sant, Toru Takimoto, Stephen Dewhurst & Sanjay B. Maggirwar. (2010) Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells. Virology 400:2, pages 224-232.
Crossref
Jinqi Ren, Yaqing Wang, Yuheng Liang, Yongqing Zhang, Shilai Bao & Zhiheng Xu. (2010) Methylation of Ribosomal Protein S10 by Protein-arginine Methyltransferase 5 Regulates Ribosome Biogenesis. Journal of Biological Chemistry 285:17, pages 12695-12705.
Crossref
Guomei Tang, Ming D. Perng, Sherwin Wilk, Roy Quinlan & James E. Goldman. (2010) Oligomers of Mutant Glial Fibrillary Acidic Protein (GFAP) Inhibit the Proteasome System in Alexander Disease Astrocytes, and the Small Heat Shock Protein αB-Crystallin Reverses the Inhibition. Journal of Biological Chemistry 285:14, pages 10527-10537.
Crossref
Subhas C. Biswas, Yi Zhang, Grace Iyirhiaro, Ryan T. Willett, Yasmilde Rodriguez Gonzalez, Sean P. Cregan, Ruth S. Slack, David S. Park & Lloyd A. Greene. (2010) Sertad1 Plays an Essential Role in Developmentaland Pathological Neuron Death. The Journal of Neuroscience 30:11, pages 3973-3982.
Crossref
Velusamy Rangasamy, Rajakishore Mishra, Suneet Mehrotra, Gautam Sondarva, Rajarshi S. Ray, Arundhati Rao, Malay Chatterjee, Basabi Rana & Ajay Rana. (2010) Estrogen Suppresses MLK3-Mediated Apoptosis Sensitivity in ER+ Breast Cancer Cells. Cancer Research 70:4, pages 1731-1740.
Crossref
Ashley L. Lennox & Beth Stronach. (2010) POSH misexpression induces caspase-dependent cell death in Drosophila. Developmental Dynamics 239:2, pages 651-664.
Crossref
Hubert Robitaille, Carolyne Simard-Bisson, Danielle Larouche, Robert M. Tanguay, Richard Blouin & Lucie Germain. (2010) The Small Heat-Shock Protein Hsp27 Undergoes ERK-Dependent Phosphorylation and Redistribution to the Cytoskeleton in Response to Dual Leucine Zipper-Bearing Kinase Expression. Journal of Investigative Dermatology 130:1, pages 74-85.
Crossref
Hong Chen, Qun Chen, Ming Fang & Yan Mi. (2010) microRNA-181b targets MLK2 in HL-60 cells. Science China Life Sciences 53:1, pages 101-106.
Crossref
Yonat Keshet & Rony Seger. 2010. MAP Kinase Signaling Protocols. MAP Kinase Signaling Protocols 3 38 .
Nicolas Bisson & Thomas Moss. (2009) Mlk2. AfCS-Nature Molecule Pages.
Crossref
Nicolas Bisson & Thomas Moss. (2009) Mlk1. AfCS-Nature Molecule Pages.
Crossref
Eric T. Cole, Yu Zhan, Widian F. Abi Saab, Amanda C. Korchnak, Brian P. Ashburner & Deborah N. Chadee. (2009) Mixed lineage kinase 3 negatively regulates IKK activity and enhances etoposide-induced cell death. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1793:12, pages 1811-1818.
Crossref
Saurabh SenAndrew B. West. (2009) The Therapeutic Potential of LRRK2 and α-Synuclein in Parkinson's Disease. Antioxidants & Redox Signaling 11:9, pages 2167-2187.
Crossref
Andrew A Sproul, Zhiheng Xu, Michael Wilhelm, Stephen Gire & Lloyd A Greene. (2009) Cbl negatively regulates JNK activation and cell death. Cell Research 19:8, pages 950-961.
Crossref
Jean-Philippe Couture & Richard Blouin. (2009) DLK. AfCS-Nature Molecule Pages.
Crossref
Masahiro Nagao & Hideaki Hayashi. (2009) Mixed lineage kinase 2 and hippocalcin are localized in Lewy bodies of Parkinson's disease. Journal of the Neurological Sciences 281:1-2, pages 51-54.
Crossref
Sue-Ann Mok, Karen Lund & Robert B Campenot. (2009) A retrograde apoptotic signal originating in NGF-deprived distal axons of rat sympathetic neurons in compartmented cultures. Cell Research 19:5, pages 546-560.
Crossref
Eun Sun Cho, Young Jin Jang, Nam Joo Kang, Mun Kyung Hwang, Yong Taek Kim, Ki Won Lee & Hyong Joo Lee. (2009) Cocoa procyanidins attenuate 4-hydroxynonenal-induced apoptosis of PC12 cells by directly inhibiting mitogen-activated protein kinase kinase 4 activity. Free Radical Biology and Medicine 46:10, pages 1319-1327.
Crossref
Alex Daviau, Marco Di Fruscio & Richard Blouin. (2009) The mixed-lineage kinase DLK undergoes Src-dependent tyrosine phosphorylation and activation in cells exposed to vanadate or platelet-derived growth factor (PDGF). Cellular Signalling 21:4, pages 577-587.
Crossref
Arthur L. BurnettIIII. 2009. Sexual Function in the Prostate Cancer Patient. Sexual Function in the Prostate Cancer Patient 111 128 .
Girish C. Daginakatte, Scott M. Gianino, Nina W. Zhao, Alexander S. Parsadanian & David H. Gutmann. (2008) Increased c-Jun-NH2-Kinase Signaling in Neurofibromatosis-1 Heterozygous Microglia Drives Microglia Activation and Promotes Optic Glioma Proliferation. Cancer Research 68:24, pages 10358-10366.
Crossref
Wenwen Shen & Clinton Jones. (2008) Open Reading Frame 2, Encoded by the Latency-Related Gene of Bovine Herpesvirus 1, Has Antiapoptotic Activity in Transiently Transfected Neuroblastoma Cells. Journal of Virology 82:21, pages 10940-10945.
Crossref
T F Franke. (2008) PI3K/Akt: getting it right matters. Oncogene 27:50, pages 6473-6488.
Crossref
D N Dhanasekaran & E P Reddy. (2008) JNK signaling in apoptosis. Oncogene 27:48, pages 6245-6251.
Crossref
X.-R. Wen, C. Li, Y.-Y. Zong, C.-Z. Yu, J. Xu, D. Han & G.-Y. Zhang. (2008) Dual inhibitory roles of geldanamycin on the c-Jun NH2-terminal kinase 3 signal pathway through suppressing the expression of mixed-lineage kinase 3 and attenuating the activation of apoptosis signal-regulating kinase 1 via facilitating the activation of Akt in ischemic brain injury. Neuroscience 156:3, pages 483-497.
Crossref
Anthony K.F. Liou, Rehana K. Leak, Lihua Li & Michael J. Zigmond. (2008) Wild-type LRRK2 but not its mutant attenuates stress-induced cell death via ERK pathway. Neurobiology of Disease 32:1, pages 116-124.
Crossref
Barbara L. Apostol, Danielle A. Simmons, Chiara Zuccato, Katalin Illes, Judit Pallos, Malcolm Casale, Paola Conforti, Catarina Ramos, Margaret Roarke, Satish Kathuria, Elena Cattaneo, J. Lawrence Marsh & Leslie Michels Thompson. (2008) CEP-1347 reduces mutant huntingtin-associated neurotoxicity and restores BDNF levels in R6/2 mice. Molecular and Cellular Neuroscience 39:1, pages 8-20.
Crossref
Subhas C. Biswas, Jean Buteau & Lloyd A. Greene. (2008) Glucagon-like Peptide-1 (GLP-1) Diminishes Neuronal Degeneration and Death Caused by NGF Deprivation by Suppressing Bim Induction. Neurochemical Research 33:9, pages 1845-1851.
Crossref
Kirsten Mielke. (2008) Growth-arrest-dependent expression and phosphorylation of p27kip at serine10 is mediated by the JNK pathway in C6 glioma cells. Molecular and Cellular Neuroscience 38:3, pages 301-311.
Crossref
Shujing Liu, Mei Yu, Ying He, Lin Xiao, Fang Wang, Changcheng Song, Shuhan Sun, Changquan Ling & Zhiheng Xu. (2008) Melittin prevents liver cancer cell metastasis through inhibition of the Rac1-dependent pathway. Hepatology 47:6, pages 1964-1973.
Crossref
Silke Plaumann, Roland Blume, Svenja Börchers, Hans Jürgen Steinfelder, Willhart Knepel & Elke Oetjen. (2008) Activation of the Dual-Leucine-Zipper-Bearing Kinase and Induction of β-Cell Apoptosis by the Immunosuppressive Drug Cyclosporin A. Molecular Pharmacology 73:3, pages 652-659.
Crossref
Robert E. Burke. (2008) Programmed cell death and new discoveries in the genetics of parkinsonism. Journal of Neurochemistry 104:4, pages 875-890.
Crossref
Xiqun Chen, Margarita Rzhetskaya, Tatyana Kareva, Ross Bland, Matthew J. During, A. William Tank, Nikolai Kholodilov & Robert E. Burke. (2008) Antiapoptotic and Trophic Effects of Dominant-Negative Forms of Dual Leucine Zipper Kinase in Dopamine Neurons of the Substantia Nigra In Vivo . The Journal of Neuroscience 28:3, pages 672-680.
Crossref
S J Liu, Y M Sun, D F Tian, Y C He, L Zeng, Y He, C Q Ling & S H Sun. (2008) Downregulated NM23-H1 expression is associated with intracranial invasion of nasopharyngeal carcinoma. British Journal of Cancer 98:2, pages 363-369.
Crossref
Steven H. Green, Richard A. Altschuler & Josef M. Miller. 2008. Auditory Trauma, Protection, and Repair. Auditory Trauma, Protection, and Repair 275 319 .
Clinton Jones & Shafiqul Chowdhury. (2008) A review of the biology of bovine herpesvirus type 1 (BHV-1), its role as a cofactor in the bovine respiratory disease complex and development of improved vaccines. Animal Health Research Reviews 8:2, pages 187-205.
Crossref
Yiming Sun, Tao Yang & Zhiheng Xu. (2007) The JNK Pathway and Neuronal Migration. Journal of Genetics and Genomics 34:11, pages 957-965.
Crossref
Rajakishore Mishra, Manoj K. Barthwal, Gautam Sondarva, Basabi Rana, Lucas Wong, Malay Chatterjee, James R. Woodgett & Ajay Rana. (2007) Glycogen Synthase Kinase-3β Induces Neuronal Cell Death via Direct Phosphorylation of Mixed Lineage Kinase 3. Journal of Biological Chemistry 282:42, pages 30393-30405.
Crossref
Subhas C. Biswas, Yijie Shi, Andrew Sproul & Lloyd A. Greene. (2007) Pro-apoptotic Bim Induction in Response to Nerve Growth Factor Deprivation Requires Simultaneous Activation of Three Different Death Signaling Pathways. Journal of Biological Chemistry 282:40, pages 29368-29374.
Crossref
Luxuan Guo, Payal N. Gandhi, Wen Wang, Robert B. Petersen, Amy L. Wilson-Delfosse & Shu G. Chen. (2007) The Parkinson’s disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase thatstimulates kinase activity. Experimental Cell Research 313:16, pages 3658-3670.
Crossref
Hye-Young Hong & Byung-Chul Kim. (2007) Mixed lineage kinase 3 connects reactive oxygen species to c-Jun NH2-terminal kinase-induced mitochondrial apoptosis in genipin-treated PC3 human prostate cancer cells. Biochemical and Biophysical Research Communications 362:2, pages 307-312.
Crossref
Shaheen A. Alam, Barbara K. Robinson, Jie Huang & Steven H. Green. (2007) Prosurvival and proapoptotic intracellular signaling in rat spiral ganglion neurons in vivo after the loss of hair cells. The Journal of Comparative Neurology 503:6, pages 832-852.
Crossref
Masayuki Furukawa, Jörg Ebmeyer, Kwang Pak, Darrell A. Austin, Åsa Melhus, Nicholas J. G. Webster & Allen F. Ryan. (2007) Jun N-Terminal Protein Kinase Enhances Middle Ear Mucosal Proliferation during Bacterial Otitis Media. Infection and Immunity 75:5, pages 2562-2571.
Crossref
Jie CUI, Ming ZHANG, Yong-qing ZHANG & Zhi-heng XU. (2007) JNK pathway: diseases and therapeutic potential. Acta Pharmacologica Sinica 28:5, pages 601-608.
Crossref
M I Smith & M Deshmukh. (2007) Endoplasmic reticulum stress-induced apoptosis requires bax for commitment and Apaf-1 for execution in primary neurons. Cell Death & Differentiation 14:5, pages 1011-1019.
Crossref
Deborah G. Nguyen, Hong Yin, Yingyao Zhou, Karen C. Wolff, Kelli L. Kuhen & Jeremy S. Caldwell. (2007) Identification of novel therapeutic targets for HIV infection through functional genomic cDNA screening. Virology 362:1, pages 16-25.
Crossref
Matthew E. Handley, Jane Rasaiyaah, Benjamin M. Chain & David R. Katz. (2007) Mixed lineage kinases (MLKs): a role in dendritic cells, inflammation and immunity?. International Journal of Experimental Pathology 88:2, pages 111-126.
Crossref
Robert E Burke. (2007) Kinase signaling pathways: potential therapeutic targets in Parkinson’s disease. Future Neurology 2:1, pages 39-49.
Crossref
Florencia Meyer, Sandra Perez, Vicki Geiser, Mark Sintek, Melissa Inman & Clinton Jones. (2007) A Protein Encoded by the Bovine Herpesvirus 1 Latency-Related Gene Interacts with Specific Cellular Regulatory Proteins, Including CCAAT Enhancer Binding Protein Alpha. Journal of Virology 81:1, pages 59-67.
Crossref
Michael Wilhelm, Zhiheng Xu, Nickolay V. Kukekov, Stephen Gire & Lloyd A. Greene. (2007) Proapoptotic Nix Activates the JNK Pathway by Interacting with POSH and Mediates Death in a Parkinson Disease Model. Journal of Biological Chemistry 282:2, pages 1288-1295.
Crossref
Guomei Tang, Zhiheng Xu & James E. Goldman. (2006) Synergistic Effects of the SAPK/JNK and the Proteasome Pathway on Glial Fibrillary Acidic Protein (GFAP) Accumulation in Alexander Disease. Journal of Biological Chemistry 281:50, pages 38634-38643.
Crossref
Q.-G. Zhang, D. Han, J. Xu, Q. Lv, R. Wang, X.-H. Yin, T.-L. Xu & G.-Y. Zhang. (2006) Ischemic preconditioning negatively regulates plenty of SH3s–mixed lineage kinase 3–Rac1 complex and c-Jun N-terminal kinase 3 signaling via activation of Akt. Neuroscience 143:2, pages 431-444.
Crossref
Quan-Guang Zhang, Hui Tian, Hong-Chun Li & Guang-Yi Zhang. (2006) Antioxidant N-acetylcysteine inhibits the activation of JNK3 mediated by the GluR6–PSD95–MLK3 signaling module during cerebral ischemia in rat hippocampus. Neuroscience Letters 408:3, pages 159-164.
Crossref
Alex Daviau, Roxanne Proulx, Karine Robitaille, Marco Di Fruscio, Robert M. Tanguay, Jacques Landry, Cam Patterson, Yves Durocher & Richard Blouin. (2006) Down-regulation of the Mixed-lineage Dual Leucine Zipper-bearing Kinase by Heat Shock Protein 70 and Its Co-chaperone CHIP. Journal of Biological Chemistry 281:42, pages 31467-31477.
Crossref
Alex Daviau, Roxanne Proulx, Karine Robitaille, Marco Di Fruscio, Robert M. Tanguay, Jacques Landry, Cam Patterson, Yves Durocher & Richard Blouin. (2006) Down-regulation of the Mixed-lineage Dual Leucine Zipper-bearing Kinase by Heat Shock Protein 70 and Its Co-chaperone CHIP. Journal of Biological Chemistry 281:42, pages 31467-31477.
Crossref
Cristina Malagelada, Elizabeth J. Ryu, Subhas C. Biswas, Vernice Jackson-Lewis & Lloyd A. Greene. (2006) RTP801 Is Elevated in Parkinson Brain Substantia Nigral Neurons and Mediates Death in Cellular Models of Parkinson's Disease by a Mechanism Involving Mammalian Target of Rapamycin Inactivation. The Journal of Neuroscience 26:39, pages 9996-10005.
Crossref
Karen Schachter, Geou-Yarh Liou, Yan Du & Kathleen Gallo. (2006) Mlk3. AfCS-Nature Molecule Pages.
Crossref
Quan-Guang Zhang, Xiao-Tian Wang, Dong Han, Xiao-Hui Yin, Guang-Yi Zhang & Tian-Le Xu. (2006) Akt inhibits MLK3/JNK3 signaling by inactivating Rac1: a protective mechanism against ischemic brain injury. Journal of Neurochemistry 98:6, pages 1886-1898.
Crossref
Ziye Sui, Shongshan Fan, Lynn Sniderhan, Elizabeth Reisinger, Angela Litzburg, Giovanni Schifitto, Harris A. Gelbard, Stephen Dewhurst & Sanjay B. Maggirwar. (2006) Inhibition of Mixed Lineage Kinase 3 Prevents HIV-1 Tat-Mediated Neurotoxicity and Monocyte Activation. The Journal of Immunology 177:1, pages 702-711.
Crossref
Karen A. Schachter, Yan Du, Anning Lin & Kathleen A. Gallo. (2006) Dynamic Positive Feedback Phosphorylation of Mixed Lineage Kinase 3 by JNK Reversibly Regulates Its Distribution to Triton-soluble Domains. Journal of Biological Chemistry 281:28, pages 19134-19144.
Crossref
Catherine A. Collins, Yogesh P. Wairkar, Sylvia L. Johnson & Aaron DiAntonio. (2006) Highwire Restrains Synaptic Growth by Attenuating a MAP Kinase Signal. Neuron 51:1, pages 57-69.
Crossref
Nickolay V. Kukekov, Zhiheng Xu & Lloyd A. Greene. (2006) Direct Interaction of the Molecular Scaffolds POSH and JIP Is Required for Apoptotic Activation of JNKs. Journal of Biological Chemistry 281:22, pages 15517-15524.
Crossref
Janusz Tucholski, Kevin A. Roth & Gail V. W. Johnson. (2006) Tissue transglutaminase overexpression in the brain potentiates calcium-induced hippocampal damage. Journal of Neurochemistry 97:2, pages 582-594.
Crossref
Georg Johannes Müller, Marie Aavang Geist, Lone Merete Veng, Mette Georgi Willesen, Flemming Fryd Johansen, Marcel Leist & Elisabetta Vaudano. (2006) A role for mixed lineage kinases in granule cell apoptosis induced by cytoskeletal disruption. Journal of Neurochemistry 96:5, pages 1242-1252.
Crossref
Ceniz Zihni, Costas Mitsopoulos, Ignatius A. Tavares, Anne J. Ridley & Jonathan D.H. Morris. (2006) Prostate-derived Sterile 20-like Kinase 2 (PSK2) Regulates Apoptotic Morphology via C-Jun N-terminal Kinase and Rho Kinase-1. Journal of Biological Chemistry 281:11, pages 7317-7323.
Crossref
Christian Johannes Gloeckner, Norbert Kinkl, Annette Schumacher, Ralf J. Braun, Eric O'Neill, Thomas Meitinger, Walter Kolch, Holger Prokisch & Marius Ueffing. (2006) The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity. Human Molecular Genetics 15:2, pages 223-232.
Crossref
Ayal Ben-Zvi, Zohar Yagil, Yamit Hagalili, Hagit Klein, Omer Lerman & Oded Behar. (2006) Semaphorin 3A and neurotrophins: a balance between apoptosis and survival signaling in embryonic DRG neurons. Journal of Neurochemistry 96:2, pages 585-597.
Crossref
Stephen J. Crocker, Shawn P. Hayley, Patrice D. Smith, Matthew P. Mount, Wiplove R. Lamba, Steven M. Callaghan, Ruth S. Slack & David S. Park. (2006) Regulation of axotomy-induced dopaminergic neuron death and c-Jun phosphorylation by targeted inhibition of cdc42 or mixed lineage kinase. Journal of Neurochemistry 96:2, pages 489-499.
Crossref
Zhiheng Xu, Andrew Sproul, Wenyi Wang, Nikolay Kukekov & Lloyd A. Greene. (2006) Siah1 Interacts with the Scaffold Protein POSH to Promote JNK Activation and Apoptosis. Journal of Biological Chemistry 281:1, pages 303-312.
Crossref
Hyukjin Cha, Surabhi Dangi, Carolyn E. Machamer & Paul Shapiro. (2006) Inhibition of mixed-lineage kinase (MLK) activity during G2-phase disrupts microtubule formation and mitotic progression in HeLa cells. Cellular Signalling 18:1, pages 93-104.
Crossref
Zhiheng Xu & Lloyd A. Greene. 2006. Regulators and Effectors of Small GTPases: Rho Family. Regulators and Effectors of Small GTPases: Rho Family 479 489 .
Yoav Shaul & Rony Seger. (2006) The Detection of MAPK Signaling. Current Protocols in Molecular Biology 73:1.
Crossref
Dhananjaya V. KalvakolanuSanjit K. Roy. (2005) CCAAT/Enhancer Binding Proteins and Interferon Signaling Pathways. Journal of Interferon & Cytokine Research 25:12, pages 757-769.
Crossref
Yan Du, Barbara C. Böck, Karen A. Schachter, Mary Chao & Kathleen A. Gallo. (2005) Cdc42 Induces Activation Loop Phosphorylation and Membrane Targeting of Mixed Lineage Kinase 3. Journal of Biological Chemistry 280:52, pages 42984-42993.
Crossref
Dong-Sheng Pei, Qiu-Hua Guan, Ya-Feng Sun, Qing-Xiu Zhang, Tian-Le Xu & Guang-Yi Zhang. (2005) N-Acetylcysteine inhibit the translocation of mixed lineage kinase-3 from cytosol to plasma membrane during transient brain ischemia in rat hippocampus. Neuroscience Letters 391:1-2, pages 38-42.
Crossref
Subhas C. Biswas, David X. Liu & Lloyd A. Greene. (2005) Bim Is a Direct Target of a Neuronal E2F-Dependent Apoptotic Pathway. The Journal of Neuroscience 25:37, pages 8349-8358.
Crossref
Yoav Shaul & Rony Seger. (2005) The Detection of MAPK Signaling. Current Protocols in Cell Biology 28:1.
Crossref
Matthew E. Handley, Manish Thakker, Gabriele Pollara, Benjamin M. Chain & David R. Katz. (2005) JNK activation limits dendritic cell maturation in response to reactive oxygen species by the induction of apoptosis. Free Radical Biology and Medicine 38:12, pages 1637-1652.
Crossref
Subhas C. Biswas, Elizabeth Ryu, Clara Park, Cristina Malagelada & Lloyd A. Greene. (2005) Puma and p53 Play Required Roles in Death Evoked in a Cellular Model of Parkinson Disease. Neurochemical Research 30:6-7, pages 839-845.
Crossref
Robert M. Silva, Chia-Yi Kuan, Pasko Rakic & Robert E. Burke. (2005) Mixed lineage kinase-c-jun N-terminal kinase signaling pathway: A new therapeutic target in Parkinson's disease. Movement Disorders 20:6, pages 653-664.
Crossref
Xiao-Hui Yin, Quan-Guang Zhang, Bei Miao & Guang-Yi Zhang. (2005) Neuroprotective effects of preconditioning ischaemia on ischaemic brain injury through inhibition of mixed-lineage kinase 3 via NMDA receptor-mediated Akt1 activation. Journal of Neurochemistry 93:4, pages 1021-1029.
Crossref
Kyle Johnson, Li Liu, Nazanin K Majd, Cindy Chavez, Paul C. Chin, Brad Morrison, Lulu Wang, Jane Park, Priti Chugh, Hsin‐Mei Chen & Santosh R. D'Mello. (2005) Inhibition of neuronal apoptosis by the cyclin‐dependent kinase inhibitor GW8510: Identification of 3′ substituted indolones as a scaffold for the development of neuroprotective drugs. Journal of Neurochemistry 93:3, pages 538-548.
Crossref
Søren Lund, Peter Porzgen, Anne Louise Mortensen, Henrik Hasseldam, Donna Bozyczko-Coyne, Siegfried Morath, Thomas Hartung, Marina Bianchi, Pietro Ghezzi, Malika Bsibsi, Sipke Dijkstra & Marcel Leist. (2005) Inhibition of microglial inflammation by the MLK inhibitor CEP-1347. Journal of Neurochemistry 92:6, pages 1439-1451.
Crossref
Zhou-shen ZHAO & Ed MANSER. (2005) PAK and other Rho-associated kinases – effectors with surprisingly diverse mechanisms of regulation. Biochemical Journal 386:2, pages 201-214.
Crossref
D Kögel, R Schomburg, E Copanaki & J H M Prehn. (2004) Regulation of gene expression by the amyloid precursor protein: inhibition of the JNK/c-Jun pathway. Cell Death & Differentiation 12:1, pages 1-9.
Crossref
Margaret M. Mc Gee, Lisa M. Greene, Susan Ledwidge, Giuseppe Campiani, Vito Nacci, Mark Lawler, D. Clive Williams & Daniela M. Zisterer. (2004) Selective Induction of Apoptosis by the Pyrrolo-1,5-benzoxazepine 7-[{Dimethylcarbamoyl}oxy]-6-(2-naphthyl)pyrrolo-[2,1- d ] (1,5)-benzoxazepine (PBOX-6) in Leukemia Cells Occurs via the c-Jun NH 2 -Terminal Kinase-Dependent Phosphorylation and Inactivation of Bcl-2 and Bcl- XL . Journal of Pharmacology and Experimental Therapeutics 310:3, pages 1084-1095.
Crossref
Ki-Yong Kim, Byung-Chul Kim, Zhiheng Xu & Seong-Jin Kim. (2004) Mixed Lineage Kinase 3 (MLK3)-activated p38 MAP Kinase Mediates Transforming Growth Factor-β-induced Apoptosis in Hepatoma Cells. Journal of Biological Chemistry 279:28, pages 29478-29484.
Crossref
Yong-Yeon Cho, Ann M. Bode, Hideya Mizuno, Bu Young Choi, Hong Seok Choi & Zigang Dong. (2004) A Novel Role for Mixed-Lineage Kinase-Like Mitogen-Activated Protein Triple Kinase α in Neoplastic Cell Transformation and Tumor Development. Cancer Research 64:11, pages 3855-3864.
Crossref
Hua Zhang, Wei Wu, Yan Du, Sarah J. Santos, Susan E. Conrad, Jack T. Watson, Nicholas Grammatikakis & Kathleen A. Gallo. (2004) Hsp90/p50cdc37 Is Required for Mixed-lineage Kinase (MLK) 3 Signaling. Journal of Biological Chemistry 279:19, pages 19457-19463.
Crossref
K Robitaille, A Daviau, J Tucholski, G V W Johnson, C Rancourt & R Blouin. (2004) Tissue transglutaminase triggers oligomerization and activation of dual leucine zipper-bearing kinase in calphostin C-treated cells to facilitate apoptosis. Cell Death & Differentiation 11:5, pages 542-549.
Crossref
Alcmène Chalazonitis, Fabien D'Autréaux, Udayan Guha, Tuan D. Pham, Christophe Faure, Jason J. Chen, Daniel Roman, Lixin Kan, Taube P. Rothman, John A. Kessler & Michael D. Gershon. (2004) Bone Morphogenetic Protein-2 and -4 Limit the Number of Enteric Neurons But Promote Development of a TrkC-Expressing Neurotrophin-3-Dependent Subset. The Journal of Neuroscience 24:17, pages 4266-4282.
Crossref
Joanne R. Mathiasen, Beth Ann W. McKenna, Michael S. Saporito, Ghanashyam D. Ghadge, Raymond P. Roos, Beverly P. Holskin, Zhi-Liang Wu, Stephen P. Trusko, Thomas C. Connors, Anna C. Maroney, Beth Ann Thomas, Jeffrey C. Thomas & Donna Bozyczko-Coyne. (2004) Inhibition of mixed lineage kinase 3 attenuates MPP+-induced neurotoxicity in SH-SY5Y cells. Brain Research 1003:1-2, pages 86-97.
Crossref
Hyukjin Cha, Barbara L. Smith, Kathleen Gallo, Carolyn E. Machamer & Paul Shapiro. (2004) Phosphorylation of golgin-160 by mixed lineage kinase 3. Journal of Cell Science 117:5, pages 751-760.
Crossref
Leo H. WangCagri G. BesirliEugene M. JohnsonJr.Jr.. (2004) Mixed-Lineage Kinases: A Target for the Prevention of Neurodegeneration. Annual Review of Pharmacology and Toxicology 44:1, pages 451-474.
Crossref
Jette Bisgaard Boll, Marie Aavang Geist, Gabriele S. Kaminski Schierle, Karina Petersen, Marcel Leist & Elisabetta Vaudano. (2003) Improvement of embryonic dopaminergic neurone survival in culture and after grafting into the striatum of hemiparkinsonian rats by CEP-1347. Journal of Neurochemistry 88:3, pages 698-707.
Crossref
Anindita Ganguly, Tinmarla Frances Oo, Margarita Rzhetskaya, Robert Pratt, Olga Yarygina, Takashi Momoi, Nikolai Kholodilov & Robert E. Burke. (2003) CEP11004, a novel inhibitor of the mixed lineage kinases, suppresses apoptotic death in dopamine neurons of the substantia nigra induced by 6-hydroxydopamine. Journal of Neurochemistry 88:2, pages 469-480.
Crossref
Aki Itoh, Zhili Wang, Yasuhiro Ito, Usha R Reddy & Takayuki Itoh. (2004) SP3 acts as a positive regulator on the core promoter of human ZPK gene. Biochemical and Biophysical Research Communications 313:3, pages 612-618.
Crossref
Robert S. Freeman, Robert L. Burch, Robert J. Crowder, David J. Lomb, Matthew C. Schoell, Jennifer A. Straub & Liang Xie. 2004. NGF and Related Molecules in Health and Disease. NGF and Related Molecules in Health and Disease 111 126 .
Maren Eckey, Stephan P. Tenbaum, Alberto Muñoz & Aria Baniahmad. (2003) Mixed lineage kinase 2 enhances trans-repression of Alien and nuclear receptors. Molecular and Cellular Endocrinology 213:1, pages 71-78.
Crossref
Cagri Giray Besirli & Eugene Malcolm JohnsonJr.Jr.. (2003) JNK-independent Activation of c-Jun during Neuronal Apoptosis Induced by Multiple DNA-damaging Agents. Journal of Biological Chemistry 278:25, pages 22357-22366.
Crossref
Hidehiko Inomata, Yoshitaka Nakamura, Akira Hayakawa, Hiroyuki Takata, Toshiharu Suzuki, Keiji Miyazawa & Naomi Kitamura. (2003) A Scaffold Protein JIP-1b Enhances Amyloid Precursor Protein Phosphorylation by JNK and Its Association with Kinesin Light Chain 1. Journal of Biological Chemistry 278:25, pages 22946-22955.
Crossref
Girish V Putcha, Siyuan Le, Stephan Frank, Cagri G Besirli, Kim Clark, Boyang Chu, Shari Alix, Richard J Youle, Art LaMarche, Anna C Maroney & Eugene M JohnsonJr.Jr.. (2003) JNK-Mediated BIM Phosphorylation Potentiates BAX-Dependent Apoptosis. Neuron 38:6, pages 899-914.
Crossref
James G. Bilsland & Sarah J. Harper. (2003) CEP-1347 promotes survival of NGF responsive neurones in primary DRG explants. NeuroReport 14:7, pages 995-999.
Crossref
Manoj K. Barthwal, Pradeep Sathyanarayana, Chanakya N. Kundu, Basabi Rana, Anamika Pradeep, Chandan Sharma, James R. Woodgett & Ajay Rana. (2003) Negative Regulation of Mixed Lineage Kinase 3 by Protein Kinase B/AKT Leads to Cell Survival. Journal of Biological Chemistry 278:6, pages 3897-3902.
Crossref
D. Perkins, E. F. R. Pereira & L. Aurelian. (2003) The Herpes Simplex Virus Type 2 R1 Protein Kinase (ICP10 PK) Functions as a Dominant Regulator of Apoptosis in Hippocampal Neurons Involving Activation of the ERK Survival Pathway and Upregulation of the Antiapoptotic Protein Bag-1. Journal of Virology 77:2, pages 1292-1305.
Crossref
Bradley Miller, Yu-Wen E Chang & Andrey Sorokin. (2003) Cyclooxygenase 2 inhibits SAPK activation in neuronal apoptosis. Biochemical and Biophysical Research Communications 300:4, pages 884-888.
Crossref

Displaying 200 of 211 citing articles. Use the download link below to view the full list of citing articles.

Download full citations list

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.