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DNA Dynamics and Chromosome Structure

Mre11 Complex and DNA Replication: Linkage to E2F and Sites of DNA Synthesis

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Pages 6006-6016 | Received 27 Mar 2001, Accepted 22 May 2001, Published online: 27 Mar 2023

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Domenica Cilli, Cristiana Mirasole, Rosa Pennisi, Valeria Pallotta, Angelo D'Alessandro, Antonio Antoccia, Lello Zolla, Paolo Ascenzi & Alessandra di Masi. (2014) Identification of the Interactors of Human Nibrin (NBN) and of Its 26 kDa and 70 kDa Fragments Arising from the NBN 657del5 Founder Mutation. PLoS ONE 9:12, pages e114651.
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Constance Alabert, Jimi-Carlo Bukowski-Wills, Sung-Bau Lee, Georg Kustatscher, Kyosuke Nakamura, Flavia de Lima Alves, Patrice Menard, Jakob Mejlvang, Juri Rappsilber & Anja Groth. (2014) Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components. Nature Cell Biology 16:3, pages 281-291.
Crossref
Naoyuki Hayashi, Masahiko Kobayashi, Awad Shamma, Yoko Morimura, Chiaki Takahashi & Ken-ichi Yamamoto. (2013) Regulatory interaction between NBS1 and DNMT1 responding to DNA damage. The Journal of Biochemistry 154:5, pages 429-435.
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Xiaomi Chen, Guoqi Liu & Michael Leffak. (2013) Activation of a human chromosomal replication origin by protein tethering. Nucleic Acids Research 41:13, pages 6460-6474.
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Chi-Jung Huang, Shung-Haur Yang, Chia-Long Lee, Yu-Che Cheng, Szu-Yun Tai & Chih-Cheng Chien. (2013) Ribosomal Protein S27-Like in Colorectal Cancer: A Candidate for Predicting Prognoses. PLoS ONE 8:6, pages e67043.
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Bunsyo Shiotani, Hai Dang Nguyen, Pelle Håkansson, Alexandre Maréchal, Alice Tse, Hidetoshi Tahara & Lee Zou. (2013) Two Distinct Modes of ATR Activation Orchestrated by Rad17 and Nbs1. Cell Reports 3:5, pages 1651-1662.
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Anja M. Duursma, Robert Driscoll, Josh E. Elias & Karlene A. Cimprich. (2013) A Role for the MRN Complex in ATR Activation via TOPBP1 Recruitment. Molecular Cell 50:1, pages 116-122.
Crossref
Andres J. Lopez-Contreras, Isabel Ruppen, Maria Nieto-Soler, Matilde Murga, Sara Rodriguez-Acebes, Silvia Remeseiro, Sara Rodrigo-Perez, Ana M. Rojas, Juan Mendez, Javier Muñoz & Oscar Fernandez-Capetillo. (2013) A Proteomic Characterization of Factors Enriched at Nascent DNA Molecules. Cell Reports 3:4, pages 1105-1116.
Crossref
Lorene Rozier, Yige Guo, Shaun Peterson, Mai Sato, Richard Baer, Jean Gautier & Yinghui Mao. (2013) The MRN-CtIP Pathway Is Required for Metaphase Chromosome Alignment. Molecular Cell 49:6, pages 1097-1107.
Crossref
Bilian Jin & Keith D. Robertson. 2013. Epigenetic Alterations in Oncogenesis. Epigenetic Alterations in Oncogenesis 3 29 .
Jasmina Lovric, Miguel Mano, Lorena Zentilin, Ana Eulalio, Serena Zacchigna & Mauro Giacca. (2012) Terminal Differentiation of Cardiac and Skeletal Myocytes Induces Permissivity to AAV Transduction by Relieving Inhibition Imposed by DNA Damage Response Proteins. Molecular Therapy 20:11, pages 2087-2097.
Crossref
Renier Vélez-Cruz & David G. Johnson. (2012) E2F1 and p53 Transcription Factors as Accessory Factors for Nucleotide Excision Repair. International Journal of Molecular Sciences 13:12, pages 13554-13568.
Crossref
Cecilia Boreström, Alma Forsman, Ulla Rüetschi & Lars Rymo. (2012) E2F1, ARID3A/Bright and Oct-2 factors bind to the Epstein–Barr virus C promoter, EBNA1 and oriP, participating in long-distance promoter–enhancer interactions. Journal of General Virology 93:5, pages 1065-1075.
Crossref
A. Dzikiewicz-Krawczyk, M. Mosor, D. Januszkiewicz & J. Nowak. (2011) Impact of heterozygous c.657-661del, p.I171V and p.R215W mutations in NBN on nibrin functions. Mutagenesis 27:3, pages 337-343.
Crossref
Arnaud Van Den Broeck, Damien Nissou, Elisabeth Brambilla, Beatrice Eymin & Sylvie Gazzeri. (2012) Activation of a Tip60/E2F1/ERCC1 network in human lung adenocarcinoma cells exposed to cisplatin. Carcinogenesis 33:2, pages 320-325.
Crossref
Mehlika Hazar-Rethinam, Liliana Endo-Munoz, Orla Gannon & Nicholas Saunders. (2011) The Role of the E2F Transcription Factor Family in UV-Induced Apoptosis. International Journal of Molecular Sciences 12:12, pages 8947-8960.
Crossref
Rachid Drissi, Jing Wu, Yafang Hu, Carol Bockhold & Jeffrey S. Dome. (2011) Telomere Shortening Alters the Kinetics of the DNA Damage Response after Ionizing Radiation in Human Cells. Cancer Prevention Research 4:12, pages 1973-1981.
Crossref
Yong-jig Cho & Peng Liang. (2011) S-phase-coupled apoptosis in tumor suppression. Cellular and Molecular Life Sciences 68:11, pages 1883-1896.
Crossref
Travis H. Stracker & John H. J. Petrini. (2011) The MRE11 complex: starting from the ends. Nature Reviews Molecular Cell Biology 12:2, pages 90-103.
Crossref
Thirupandiyur Udayakumar, Mohammed M. Shareef, Dayssy A. Diaz, Mansoor M. Ahmed & Alan Pollack. (2010) The E2F1/Rb and p53/MDM2 Pathways in DNA Repair and Apoptosis: Understanding the Crosstalk to Develop Novel Strategies for Prostate Cancer Radiotherapy. Seminars in Radiation Oncology 20:4, pages 258-266.
Crossref
Amit Kumar, Oscar Fernandez-Capetillo & Ana C. Carrera. (2010) Nuclear phosphoinositide 3-kinase β controls double-strand break DNA repair. Proceedings of the National Academy of Sciences 107:16, pages 7491-7496.
Crossref
Nicholas Willis & Nicholas Rhind. (2010) The Fission Yeast Rad32(Mre11)–Rad50–Nbs1 Complex Acts Both Upstream and Downstream of Checkpoint Signaling in the S-Phase DNA Damage Checkpoint. Genetics 184:4, pages 887-897.
Crossref
Neerja Karnani, Christopher M. Taylor, Ankit Malhotra & Anindya Dutta. (2010) Genomic Study of Replication Initiation in Human Chromosomes Reveals the Influence of Transcription Regulation and Chromatin Structure on Origin Selection. Molecular Biology of the Cell 21:3, pages 393-404.
Crossref
Zhenlong Wu, Shunsheng Zheng & Qiang Yu. (2009) The E2F family and the role of E2F1 in apoptosis. The International Journal of Biochemistry & Cell Biology 41:12, pages 2389-2397.
Crossref
Cary A. Moody & Laimonis A. Laimins. (2009) Human Papillomaviruses Activate the ATM DNA Damage Pathway for Viral Genome Amplification upon Differentiation. PLoS Pathogens 5:10, pages e1000605.
Crossref
Patrick S. Lin, Lisa A. McPherson, Aubrey Y. Chen, Julien Sage & James M. Ford. (2009) The role of the retinoblastoma/E2F1 tumor suppressor pathway in the lesion recognition step of nucleotide excision repair. DNA Repair 8:7, pages 795-802.
Crossref
Lu Zheng, Radhakrishnan Kanagaraj, Boris Mihaljevic, Sybille Schwendener, Alessandro A. Sartori, Bertran Gerrits, Igor Shevelev & Pavel Janscak. (2009) MRE11 complex links RECQ5 helicase to sites of DNA damage. Nucleic Acids Research 37:8, pages 2645-2657.
Crossref
Regina Waltes, Reinhard Kalb, Magtouf Gatei, Amanda W. Kijas, Markus Stumm, Alexandra Sobeck, Britta Wieland, Raymonda Varon, Yaniv Lerenthal, Martin F. Lavin, Detlev Schindler & Thilo Dörk. (2009) Human RAD50 Deficiency in a Nijmegen Breakage Syndrome-like Disorder. The American Journal of Human Genetics 84:5, pages 605-616.
Crossref
Mary E. Porter-Goff & Nicholas Rhind. (2009) The Role of MRN in the S-Phase DNA Damage Checkpoint Is Independent of Its Ctp1-dependent Roles in Double-Strand Break Repair and Checkpoint Signaling. Molecular Biology of the Cell 20:7, pages 2096-2107.
Crossref
Brett Ewald, Deepa Sampath & William Plunkett. (2008) ATM and the Mre11-Rad50-Nbs1 Complex Respond to Nucleoside Analogue–Induced Stalled Replication Forks and Contribute to Drug Resistance. Cancer Research 68:19, pages 7947-7955.
Crossref
Dexi Chen, Zhiyong Yu, Zhiyi Zhu & Charles D. Lopez. (2008) E2F1 Regulates the Base Excision Repair Gene XRCC1 and Promotes DNA Repair. Journal of Biological Chemistry 283:22, pages 15381-15389.
Crossref
Qin Wen, Jennifer Scorah, Geraldine Phear, Gary Rodgers, Sheila Rodgers & Mark Meuth. (2008) A Mutant Allele of MRE11 Found in Mismatch Repair-deficient Tumor Cells Suppresses the Cellular Response to DNA Replication Fork Stress in a Dominant Negative Manner . Molecular Biology of the Cell 19:4, pages 1693-1705.
Crossref
Brian D. Beck, Su-Jung Park, Young-Ju Lee, Yaritzabel Roman, Robert A. Hromas & Suk-Hee Lee. (2008) Human Pso4 Is a Metnase (SETMAR)-binding Partner That Regulates Metnase Function in DNA Repair. Journal of Biological Chemistry 283:14, pages 9023-9030.
Crossref
Terry Ashley. 2008. Recombination and Meiosis. Recombination and Meiosis 153 194 .
Jayaraju Dheekollu, Zhong Deng, Andreas Wiedmer, Matthew D. Weitzman & Paul M. Lieberman. (2007) A Role for MRE11, NBS1, and Recombination Junctions in Replication and Stable Maintenance of EBV Episomes. PLoS ONE 2:12, pages e1257.
Crossref
Karoline C. Manthey, Stephen Opiyo, Jason G. Glanzer, Diana Dimitrova, James Elliott & Gregory G. Oakley. (2007) NBS1 mediates ATR-dependent RPA hyperphosphorylation following replication-fork stall and collapse. Journal of Cell Science 120:23, pages 4221-4229.
Crossref
Rachel A. Schwartz, Jose Alejandro Palacios, Geoffrey D. Cassell, Sarah Adam, Mauro Giacca & Matthew D. Weitzman. (2007) The Mre11/Rad50/Nbs1 Complex Limits Adeno-Associated Virus Transduction and Replication. Journal of Virology 81:23, pages 12936-12945.
Crossref
Alexandra Dirlam & Kay F. Macleod. 2005. The Cancer Handbook. The Cancer Handbook.
Ying Zhang, Chang U.K. Lim, Junqing Zhou & Howard H. Liber. (2007) The effects of NBS1 knockdown by small interfering RNA on the ionizing radiation-induced apoptosis in human lymphoblastoid cells with different p53 status. Toxicology Letters 171:1-2, pages 50-59.
Crossref
Simone Difilippantonio, Arkady Celeste, Michael J. Kruhlak, Youngsoo Lee, Michael J. Difilippantonio, Lionel Feigenbaum, Stephen P. Jackson, Peter J. McKinnon & André Nussenzweig. (2007) Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis. Journal of Experimental Medicine 204:5, pages 1003-1011.
Crossref
Travis H. Stracker, Monica Morales, Suzana S. Couto, Hussein Hussein & John H. J. Petrini. (2007) The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex. Nature 447:7141, pages 218-221.
Crossref
Juong G. Rhee, Daqing Li, Mohan Suntharalingam, Chuanfa Guo, Bert W. O’MalleyJr.Jr. & James P. Carney. (2007) Radiosensitization of head/neck sqaumous cell carcinoma by adenovirus-mediated expression of the Nbs1 protein. International Journal of Radiation Oncology*Biology*Physics 67:1, pages 273-278.
Crossref
Zhenming Xu, Hong Zan, Zsuzsanna Pal & Paolo Casali. 2007. Mechanisms of Lymphocyte Activation and Immune Regulation XI. Mechanisms of Lymphocyte Activation and Immune Regulation XI 111 127 .
Yun Wu, Joseph S. Siino, Tomohiko Sugiyama & Stephen C. Kowalczykowski. (2006) The DNA Binding Preference of RAD52 and RAD59 Proteins. Journal of Biological Chemistry 281:52, pages 40001-40009.
Crossref
Olga K. Mirzoeva, Tomohiro Kawaguchi & Russell O. Pieper. (2006) The Mre11/Rad50/Nbs1 complex interacts with the mismatch repair system and contributes to temozolomide-induced G2 arrest and cytotoxicity. Molecular Cancer Therapeutics 5:11, pages 2757-2766.
Crossref
Jean-Baptiste Vannier, Annie Depeiges, Charles White & Maria Eugenia Gallego. (2006) Two roles for Rad50 in telomere maintenance. The EMBO Journal 25:19, pages 4577-4585.
Crossref
Terry Ashley, Ann P. Gaeth, Hidehito Inagaki, Allen Seftel, Maimon M. Cohen, Lorinda K. Anderson, Hiroki Kurahashi & Beverly S. Emanuel. (2006) Meiotic Recombination and Spatial Proximity in the Etiology of the Recurrent t(11;22). The American Journal of Human Genetics 79:3, pages 524-538.
Crossref
Paolo Casali, Zsuzsanna Pal, Zhenming Xu & Hong Zan. (2006) DNA repair in antibody somatic hypermutation. Trends in Immunology 27:7, pages 313-321.
Crossref
F M Frame, H A Rogoff, M T Pickering, W D Cress & T F Kowalik. (2006) E2F1 induces MRN foci formation and a cell cycle checkpoint response in human fibroblasts. Oncogene 25:23, pages 3258-3266.
Crossref
Errol C. Friedberg, Graham C. Walker, Wolfram Siede, Richard D. Wood, Roger A. Schultz & Tom Ellenberger. 2005. DNA Repair and Mutagenesis. DNA Repair and Mutagenesis 711 750 .
Valerie Garcia, Kanji Furuya & Antony M. Carr. (2005) Identification and functional analysis of TopBP1 and its homologs. DNA Repair 4:11, pages 1227-1239.
Crossref
Yen-Chung Chen, Yi-Ning Su, Po-Chien Chou, Wei-Chung Chiang, Ming-Cheng Chang, Liang-Shun Wang, Shu-Chun Teng & Kou-Juey Wu. (2005) Overexpression of NBS1 Contributes to Transformation through the Activation of Phosphatidylinositol 3-Kinase/Akt. Journal of Biological Chemistry 280:37, pages 32505-32511.
Crossref
Parker L. Andersen, Honglin Zhou, Landon Pastushok, Trevor Moraes, Sean McKenna, Barry Ziola, Michael J. Ellison, Vishva M. Dixit & Wei Xiao. (2005) Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and Uev1A. Journal of Cell Biology 170:5, pages 745-755.
Crossref
Simone Difilippantonio, Arkady Celeste, Oscar Fernandez-Capetillo, Hua-Tang Chen, Bernardo Reina San Martin, Francois Van Laethem, Yong-Ping Yang, Galina V. Petukhova, Michael Eckhaus, Lionel Feigenbaum, Katia Manova, Michael Kruhlak, R. Daniel Camerini-Otero, Shyam Sharan, Michel Nussenzweig & André Nussenzweig. (2005) Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models. Nature Cell Biology 7:7, pages 675-685.
Crossref
Travis H. Stracker, Darwin V. Lee, Christian T. Carson, Felipe D. Araujo, David A. Ornelles & Matthew D. Weitzman. (2005) Serotype-Specific Reorganization of the Mre11 Complex by Adenoviral E4orf3 Proteins. Journal of Virology 79:11, pages 6664-6673.
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Michelle S Longworth, Regina Wilson & Laimonis A Laimins. (2005) HPV31 E7 facilitates replication by activating E2F2 transcription through its interaction with HDACs. The EMBO Journal 24:10, pages 1821-1830.
Crossref
Caroline E. Lilley, Christian T. Carson, Alysson R. Muotri, Fred H. Gage & Matthew D. Weitzman. (2005) DNA repair proteins affect the lifecycle of herpes simplex virus 1. Proceedings of the National Academy of Sciences 102:16, pages 5844-5849.
Crossref
Desssislava K Dimova & Nicholas J Dyson. (2005) The E2F transcriptional network: old acquaintances with new faces. Oncogene 24:17, pages 2810-2826.
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Thomas R Berton, David L Mitchell, Ruifeng Guo & David G Johnson. (2005) Regulation of epidermal apoptosis and DNA repair by E2F1 in response to ultraviolet B radiation. Oncogene 24:15, pages 2449-2460.
Crossref
Joseph A Farah, Gareth Cromie, Walter W Steiner & Gerald R Smith. (2005) A Novel Recombination Pathway Initiated by the Mre11/Rad50/Nbs1 Complex Eliminates Palindromes During Meiosis in Schizosaccharomyces pombe. Genetics 169:3, pages 1261-1274.
Crossref
Bernardo Reina-San-Martin, Michel C. Nussenzweig, André Nussenzweig & Simone Difilippantonio. (2005) Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1. Proceedings of the National Academy of Sciences 102:5, pages 1590-1595.
Crossref
Nadine Puget, Melodie Knowlton & Ralph Scully. (2005) Molecular analysis of sister chromatid recombination in mammalian cells. DNA Repair 4:2, pages 149-161.
Crossref
Oleksi Petrenko & Ute M. Moll. (2005) Macrophage Migration Inhibitory Factor MIF Interferes with the Rb-E2F Pathway. Molecular Cell 17:2, pages 225-236.
Crossref
Jennifer L. Lavrrar & Peggy J. Farnham. (2004) The Use of Transient Chromatin Immunoprecipitation Assays to Test Models for E2F1-specific Transcriptional Activation. Journal of Biological Chemistry 279:44, pages 46343-46349.
Crossref
Jacob G. Robison, James Elliott, Kathleen Dixon & Gregory G. Oakley. (2004) Replication Protein A and the Mre11·Rad50·Nbs1 Complex Co-localize and Interact at Sites of Stalled Replication Forks. Journal of Biological Chemistry 279:33, pages 34802-34810.
Crossref
A.M.R. Taylor, A. Groom & P.J. Byrd. (2004) Ataxia-telangiectasia-like disorder (ATLD)—its clinical presentation and molecular basis. DNA Repair 3:8-9, pages 1219-1225.
Crossref
Craig Stevens & Nicholas B. La Thangue. (2004) The emerging role of E2F-1 in the DNA damage response and checkpoint control. DNA Repair 3:8-9, pages 1071-1079.
Crossref
Manuel Stucki & Stephen P. Jackson. (2004) MDC1/NFBD1: a key regulator of the DNA damage response in higher eukaryotes. DNA Repair 3:8-9, pages 953-957.
Crossref
Travis J. Taylor & David M. Knipe. (2004) Proteomics of Herpes Simplex Virus Replication Compartments: Association of Cellular DNA Replication, Repair, Recombination, and Chromatin Remodeling Proteinswith ICP8. Journal of Virology 78:11, pages 5856-5866.
Crossref
Xiaohua Wu, Dror Avni, Takuya Chiba, Feng Yan, Qiping Zhao, Yafang Lin, Henry Heng & David Livingston. (2004) SV40 T antigen interacts with Nbs1 to disrupt DNA replication control. Genes & Development 18:11, pages 1305-1316.
Crossref
John T. Powers, SungKi Hong, Christopher N. Mayhew, Pamela M. Rogers, Erik S. Knudsen & David G. Johnson. (2004) E2F1 Uses the ATM Signaling Pathway to Induce p53 and Chk2 Phosphorylation and Apoptosis. Molecular Cancer Research 2:4, pages 203-214.
Crossref
Cheryl D. Warren, D. Mark Eckley, Marina S. Lee, Joseph S. Hanna, Adam Hughes, Brian Peyser, Chunfa Jie, Rafael Irizarry & Forrest A. Spencer. (2004) S-Phase Checkpoint Genes Safeguard High-Fidelity Sister Chromatid Cohesion. Molecular Biology of the Cell 15:4, pages 1724-1735.
Crossref
Andrej Dudáš & Miroslav Chovanec. (2004) DNA double-strand break repair by homologous recombination. Mutation Research/Reviews in Mutation Research 566:2, pages 131-167.
Crossref
Pietro Pichierri & Annapaola Franchitto. (2004) Werner syndrome protein, the MRE11 complex and ATR: menage-à-trois in guarding genome stability during DNA replication?. BioEssays 26:3, pages 306-313.
Crossref
Angelo Manzan, Günter Pfeiffer, Melissa L Hefferin, Cara E Lang, James P Carney & Karl‐Peter Hopfner. (2004) MlaA, a hexameric ATPase linked to the Mre11 complex in archaeal genomes. EMBO reports 5:1, pages 54-59.
Crossref
Irene Ward & Junjie Chen. 2004. 1 35 .
Lili Yamasaki. 2004. Signal Transduction in Cancer. Signal Transduction in Cancer 209 239 .
Jan-Willem F Theunissen, Mark I Kaplan, Patricia A Hunt, Bret R Williams, David O Ferguson, Frederick W Alt & John H.J Petrini. (2003) Checkpoint Failure and Chromosomal Instability without Lymphomagenesis in Mre11ATLD1/ATLD1 Mice. Molecular Cell 12:6, pages 1511-1523.
Crossref
I. B. Nazarov, A. N. Smirnova, R. I. Krutilina, M. P. Svetlova, L. V. Solovjeva, A. A. Nikiforov, S-L. Oei, I. A. Zalenskaya, P. M. Yau, E. M. Bradbury & N. V. Tomilin. (2003) Dephosphorylation of Histone γ-H2AX during Repair of DNA Double-Strand Breaks in Mammalian Cells and its Inhibition by Calyculin A. Radiation Research 160:3, pages 309-317.
Crossref
George Iliakis, Ya Wang, Jun Guan & Huichen Wang. (2003) DNA damage checkpoint control in cells exposed to ionizing radiation. Oncogene 22:37, pages 5834-5847.
Crossref
Dror Avni, Hong Yang, Fabio Martelli, Francesco Hofmann, Wael M. ElShamy, Shridar Ganesan, Ralph Scully & David M. Livingston. (2003) Active Localization of the Retinoblastoma Protein in Chromatin and Its Response to S Phase DNA Damage. Molecular Cell 12:3, pages 735-746.
Crossref
Natalia I. Dmitrieva, Dmitry V. Bulavin & Maurice B. Burg. (2003) High NaCl causes Mre11 to leave the nucleus, disrupting DNA damage signaling and repair. American Journal of Physiology-Renal Physiology 285:2, pages F266-F274.
Crossref
Isabelle Frouin, Alessandra Montecucco, Silvio Spadari & Giovanni Maga. (2003) DNA replication: a complex matter. EMBO reports 4:7, pages 666-670.
Crossref
Arkady Celeste, Oscar Fernandez-Capetillo, Michael J. Kruhlak, Duane R. Pilch, David W. Staudt, Alicia Lee, Robert F. Bonner, William M. Bonner & André Nussenzweig. (2003) Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks. Nature Cell Biology 5:7, pages 675-679.
Crossref
Adrian Merlo. (2003) Genes and pathways driving glioblastomas in humans and murine disease models. Neurosurgical Review 26:3, pages 145-158.
Crossref
Karen M. Cerosaletti & Patrick Concannon. (2003) Nibrin Forkhead-associated Domain and Breast Cancer C-terminal Domain Are Both Required for Nuclear Focus Formation and Phosphorylation. Journal of Biological Chemistry 278:24, pages 21944-21951.
Crossref
Camile P. Semighini, Márcia Regina Von Zeska Kress Fagundes, Joseane Cristina Ferreira, Renata Castiglioni Pascon, Maria Helena De Souza Goldman & Gustavo Henrique Goldman. (2003) Different roles of the Mre11 complex in the DNA damage response in Aspergillus nidulans. Molecular Microbiology 48:6, pages 1693-1709.
Crossref
Yu-Chi Chiang, Shu-Chun Teng, Yi-Ning Su, Fon-Jou Hsieh & Kou-Juey Wu. (2003) c-Myc Directly Regulates the Transcription of the NBS1 Gene Involved in DNA Double-strand Break Repair. Journal of Biological Chemistry 278:21, pages 19286-19291.
Crossref
Snezana Milutinovic, Qianli Zhuang, Alain Niveleau & Moshe Szyf. (2003) Epigenomic Stress Response. Journal of Biological Chemistry 278:17, pages 14985-14995.
Crossref
Hugh Cam & Brian David Dynlacht. (2003) Emerging roles for E2F: Beyond the G1/S transition and DNA replication. Cancer Cell 3:4, pages 311-316.
Crossref
Craig Stevens & Nicholas B La Thangue. (2003) E2F and cell cycle control: a double-edged sword. Archives of Biochemistry and Biophysics 412:2, pages 157-169.
Crossref
Julie Wells, Pearlly S Yan, Meredith Cechvala, Tim Huang & Peggy J Farnham. (2003) Identification of novel pRb binding sites using CpG microarrays suggests that E2F recruits pRb to specific genomic sites during S phase. Oncogene 22:10, pages 1445-1460.
Crossref
Oleksi Petrenko, Gunter Fingerle-Rowson, Tina Peng, Robert A. Mitchell & Christine N. Metz. (2003) Macrophage Migration Inhibitory Factor Deficiency Is Associated with Altered Cell Growth and Reduced Susceptibility to Ras-mediated Transformation. Journal of Biological Chemistry 278:13, pages 11078-11085.
Crossref
Michal Goldberg, Manuel Stucki, Jacob Falck, Damien D'Amours, Dinah Rahman, Darryl Pappin, Jiri Bartek & Stephen P. Jackson. (2003) MDC1 is required for the intra-S-phase DNA damage checkpoint. Nature 421:6926, pages 952-956.
Crossref
Gregory Kennedy & Bill Sugden. 2003. Gene Transfer and Expression in Mammalian Cells. Gene Transfer and Expression in Mammalian Cells 55 70 .
Hiroshi Tauchi, Shinya Matsuura, Junya Kobayashi, Shuichi Sakamoto & Kenshi Komatsu. (2002) Nijmegen breakage syndrome gene, NBS1, and molecular links to factors for genome stability. Oncogene 21:58, pages 8967-8980.
Crossref
Lorraine S. Symington. (2002) Role of RAD52 Epistasis Group Genes in Homologous Recombination and Double-Strand Break Repair . Microbiology and Molecular Biology Reviews 66:4, pages 630-670.
Crossref
Jong-Soo Kim, Tatiana B. Krasieva, Vickie LaMorte, A. Malcolm R. Taylor & Kyoko Yokomori. (2002) Specific Recruitment of Human Cohesin to Laser-induced DNA Damage. Journal of Biological Chemistry 277:47, pages 45149-45153.
Crossref
Kevin S.W Tan, Simone T.G Leal & George A.M Cross. (2002) Trypanosoma brucei MRE11 is non-essential but influences growth, homologous recombination and DNA double-strand break repair. Molecular and Biochemical Parasitology 125:1-2, pages 11-21.
Crossref
Junya Kobayashi, Hiroshi Tauchi, Shuichi Sakamoto, Asako Nakamura, Ken-ichi Morishima, Shinya Matsuura, Toshiko Kobayashi, Katsuyuki Tamai, Keiji Tanimoto & Kenshi Komatsu. (2002) NBS1 Localizes to γ-H2AX Foci through Interaction with the FHA/BRCT Domain. Current Biology 12:21, pages 1846-1851.
Crossref
Dianne C. Daniel. (2002) Highlight: BRCA1 and BRCA2 proteins in breast cancer. Microscopy Research and Technique 59:1, pages 68-83.
Crossref
Martijn de Jager & Roland Kanaar. (2002) Genome instability and Rad50 S : subtle yet severe . Genes & Development 16:17, pages 2173-2178.
Crossref
Carla F. Bender, Michael L. Sikes, Ruth Sullivan, Leslie Erskine Huye, Michelle M. Le Beau, David B. Roth, Olga K. Mirzoeva, Eugene M. Oltz & John H. J. Petrini. (2002) Cancer predisposition and hematopoietic failure in Rad50 S/S mice . Genes & Development 16:17, pages 2237-2251.
Crossref
Nicholas P. Robinson, Richard McCulloch, Colin Conway, Alison Browitt & J. David Barry. (2002) Inactivation of Mre11 Does Not Affect VSG Gene Duplication Mediated by Homologous Recombination in Trypanosoma brucei. Journal of Biological Chemistry 277:29, pages 26185-26193.
Crossref
Travis H. Stracker, Christian T. Carson & Matthew D. Weitzman. (2002) Adenovirus oncoproteins inactivate the Mre11–Rad50–NBS1 DNA repair complex. Nature 418:6895, pages 348-352.
Crossref
Arkady CelesteSimone PetersenPeter J. RomanienkoOscar Fernandez-CapetilloHua Tang ChenOlga A. SedelnikovaBernardo Reina-San-MartinVincenzo CoppolaEric MeffreMichael J. DifilippantonioChristophe RedonDuane R. PilchAlexandru OlaruMichael EckhausR. Daniel Camerini-OteroLino TessarolloFerenc LivakKatia ManovaWilliam M. BonnerMichel C. NussenzweigAndré Nussenzweig. (2002) Genomic Instability in Mice Lacking Histone H2AX. Science 296:5569, pages 922-927.
Crossref
Damien D'Amours & Stephen P. Jackson. (2002) The MRE11 complex: at the crossroads of DNA repair and checkpoint signalling. Nature Reviews Molecular Cell Biology 3:5, pages 317-327.
Crossref
Annapaola Franchitto & Pietro Pichierri. (2002) Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrest. Journal of Cell Biology 157:1, pages 19-30.
Crossref
Bret R. Williams, Olga K. Mirzoeva, William F. Morgan, Junyu Lin, Wesley Dunnick & John H.J. Petrini. (2002) A Murine Model of Nijmegen Breakage Syndrome. Current Biology 12:8, pages 648-653.
Crossref
Parvin T. Yazdi, Yi Wang, Song Zhao, Nimitt Patel, Eva Y.-H.P. Lee & Jun Qin. (2002) SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint. Genes & Development 16:5, pages 571-582.
Crossref
Jacob Falck, John H.J. Petrini, Bret R. Williams, Jiri Lukas & Jiri Bartek. (2002) The DNA damage-dependent intra–S phase checkpoint is regulated by parallel pathways. Nature Genetics 30:3, pages 290-294.
Crossref
Hannah L Klein & Kenneth N Kreuzer. (2002) Replication, Recombination, and Repair. Molecular Cell 9:3, pages 471-480.
Crossref
Karl-Peter Hopfner, Christopher D Putnam & John A Tainer. (2002) DNA double-strand break repair from head to tail. Current Opinion in Structural Biology 12:1, pages 115-122.
Crossref
Amy S. Weinmann, Pearlly S. Yan, Matthew J. Oberley, Tim Hui-Ming Huang & Peggy J. Farnham. (2002) Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis. Genes & Development 16:2, pages 235-244.
Crossref
Julia M Sidorova & Linda L Breeden. (2002) Precocious S-Phase Entry in Budding Yeast Prolongs Replicative State and Increases Dependence Upon Rad53 for Viability. Genetics 160:1, pages 123-136.
Crossref
Jeffrey M. Trimarchi & Jacqueline A. Lees. (2002) Sibling rivalry in the E2F family. Nature Reviews Molecular Cell Biology 3:1, pages 11-20.
Crossref
Julie Wells & Peggy J. Farnham. (2002) Characterizing transcription factor binding sites using formaldehyde crosslinking and immunoprecipitation. Methods 26:1, pages 48-56.
Crossref
Kirill S. Lobachev, Dmitry A. Gordenin & Michael A. Resnick. (2002) The Mre11 Complex Is Required for Repair of Hairpin-Capped Double-Strand Breaks and Prevention of Chromosome Rearrangements. Cell 108:2, pages 183-193.
Crossref
Lei Zheng & Wen-Hwa Lee. 2002. 13 50 .
Jiri Bartek & Jiri Lukas. (2001) Mammalian G1- and S-phase checkpoints in response to DNA damage. Current Opinion in Cell Biology 13:6, pages 738-747.
Crossref
Alison Mitchell. (2001) The replication connection. Nature Reviews Molecular Cell Biology 2:9, pages 643-643.
Crossref

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