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Molecular and Cellular Biology Volume 21, 2001 - Issue 20
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Mammalian Genetic Models with Minimal or Complex Phenotypes

Hematopoietic Protein Tyrosine Phosphatase Suppresses Extracellular Stimulus-Regulated Kinase Activation

Marcela Gronda1 Medical Biophysics, University of Toronto, Princess Margaret Hospital and Ontario Cancer Institute, Toronto, OntarioM5G 2M9, Canada
,
Sara Arab1 Medical Biophysics, University of Toronto, Princess Margaret Hospital and Ontario Cancer Institute, Toronto, OntarioM5G 2M9, Canada
,
Barbara Iafrate1 Medical Biophysics, University of Toronto, Princess Margaret Hospital and Ontario Cancer Institute, Toronto, OntarioM5G 2M9, Canada
,
Haruhiko Suzuki2 Nagoya School of Medicine, Showa-ku, Nagoya464, Japan
&
Brent W. Zanke1 Medical Biophysics, University of Toronto, Princess Margaret Hospital and Ontario Cancer Institute, Toronto, OntarioM5G 2M9, Canada;3 Departments of MedicineCorrespondence[email protected]
Pages 6851-6858 | Received 13 Feb 2001, Accepted 19 Jul 2001, Published online: 27 Mar 2023

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Jaclyn W. McAlees & Virginia M. Sanders. (2009) Hematopoietic Protein Tyrosine Phosphatase Mediates β2-Adrenergic Receptor-Induced Regulation of p38 Mitogen-Activated Protein Kinase in B Lymphocytes. Molecular and Cellular Biology 29:3, pages 675-686.
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Konstantina Nika, Céline Charvet, Scott Williams, Lutz Tautz, Shane Bruckner, Souad Rahmouni, Nunzio Bottini, Stephen P. Schoenberger, Gottfried Baier, Amnon Altman & Tomas Mustelin. (2006) Lipid Raft Targeting of Hematopoietic Protein Tyrosine Phosphatase by Protein Kinase C θ-Mediated Phosphorylation. Molecular and Cellular Biology 26:5, pages 1806-1816.
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Lutz Tautz, Maurizio Pellecchia & Tomas Mustelin. (2006) Targeting the PTPome in human disease. Expert Opinion on Therapeutic Targets 10:1, pages 157-177.
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Rob Hooft van Huijsduijnen, Sébastien Wälchli, Mark Ibberson & Axel Harrenga. (2002) Protein tyrosine phosphatases as drug targets: PTP1B and beyond. Expert Opinion on Therapeutic Targets 6:6, pages 637-647.
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Randy Shen, Ying-Bin Ouyang, Cheng-Kui Qu, Andres Alonso, Lindsey Sperzel, Tomas Mustelin, Mark H. Kaplan & Gen-Sheng Feng. (2002) Grap Negatively Regulates T-Cell Receptor-Elicited Lymphocyte Proliferation and Interleukin-2 Induction. Molecular and Cellular Biology 22:10, pages 3230-3236.
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Wiljan J. A. J. Hendriks, Remco T. P. van Cruchten & Rafael Pulido. (2023) Hereditable variants of classical protein tyrosine phosphatase genes: Will they prove innocent or guilty?. Frontiers in Cell and Developmental Biology 10.
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Vaishali V. Inamdar, Haritha Reddy, Carol Dangelmaier, John C. Kostyak & Satya P. Kunapuli. (2019) The protein tyrosine phosphatase PTPN7 is a negative regulator of ERK activation and thromboxane generation in platelets. Journal of Biological Chemistry 294:33, pages 12547-12554.
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Goutham Narla, Jaya Sangodkar & Christopher B. Ryder. (2018) The impact of phosphatases on proliferative and survival signaling in cancer. Cellular and Molecular Life Sciences 75:15, pages 2695-2718.
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Wiljan J. A. J. Hendriks & Frank-D Böhmer. 2016. Protein Tyrosine Phosphatases in Cancer. Protein Tyrosine Phosphatases in Cancer 47 113 .
Yongliang Zhang, Kalyan C. Nallaparaju, Xin Liu, Huipeng Jiao, Joseph M. Reynolds, Zhi-Xin Wang & Chen Dong. (2015) MAPK Phosphatase 7 Regulates T Cell Differentiation via Inhibiting ERK-Mediated IL-2 Expression. The Journal of Immunology 194:7, pages 3088-3095.
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Huiyun Seo, In-Seon Lee, Jae Eun Park, Sung Goo Park, Do Hee Lee, Byoung Chul Park & Sayeon Cho. (2013) Role of Protein Tyrosine Phosphatase Non-Receptor Type 7 in the Regulation of TNF-α Production in RAW 264.7 Macrophages. PLoS ONE 8:11, pages e78776.
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Wiljan J.A.J. Hendriks & Rafael Pulido. (2013) Protein tyrosine phosphatase variants in human hereditary disorders and disease susceptibilities. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1832:10, pages 1673-1696.
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Ei Kawahara, Shiori Maenaka, Eri Shimada, Yoshihiro Nishimura & Hiroshi Sakurai. (2013) Dynamic Regulation of Extracellular Signal-Regulated Kinase (ERK) by Protein Phosphatase 2A Regulatory Subunit B56γ1 in Nuclei Induces Cell Migration. PLoS ONE 8:5, pages e63729.
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Kelly A. Pike & Michel L. Tremblay. (2013) Regulating naïve and memory CD8 T cell homeostasis - a role for protein tyrosine phosphatases. FEBS Journal 280:2, pages 432-444.
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Wiljan J. A. J. Hendriks, Ari Elson, Sheila Harroch, Rafael Pulido, Andrew Stoker & Jeroen den Hertog. (2013) Protein tyrosine phosphatases in health and disease. FEBS Journal 280:2, pages 708-730.
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D.J. Pagliarini, F.L. Robinson, C.A. Worby & J.E. Dixon. 2013. Encyclopedia of Biological Chemistry III. Encyclopedia of Biological Chemistry III 377 383 .
D.J. Pagliarini, F.L. Robinson, C.A. Worby & J.E. Dixon. 2013. Encyclopedia of Biological Chemistry. Encyclopedia of Biological Chemistry 648 653 .
Stephanie M. Stanford, Novella Rapini & Nunzio Bottini. (2012) Regulation of TCR signalling by tyrosine phosphatases: from immune homeostasis to autoimmunity. Immunology 137:1, pages 1-19.
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Eduard Sergienko, Jian Xu, Wallace H. Liu, Russell Dahl, David A. Critton, Ying Su, Brock T. Brown, Xochella Chan, Li Yang, Ekaterina V. Bobkova, Stefan Vasile, Hongbin Yuan, Justin Rascon, Sharon Colayco, Shyama Sidique, Nicholas D. P. Cosford, Thomas D. Y. Chung, Tomas Mustelin, Rebecca Page, Paul J. Lombroso & Lutz Tautz. (2011) Inhibition of Hematopoietic Protein Tyrosine Phosphatase Augments and Prolongs ERK1/2 and p38 Activation. ACS Chemical Biology 7:2, pages 367-377.
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Ekaterina V. Bobkova, Wallace H. Liu, Sharon Colayco, Justin Rascon, Stefan Vasile, Carlton Gasior, David A. Critton, Xochella Chan, Russell Dahl, Ying Su, Eduard Sergienko, Thomas D. Y. Chung, Tomas Mustelin, Rebecca Page & Lutz Tautz. (2010) Inhibition of the Hematopoietic Protein Tyrosine Phosphatase by Phenoxyacetic Acids. ACS Medicinal Chemistry Letters 2:2, pages 113-118.
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Roberta R. Ruela-de-Sousa, Karla C.S. Queiroz, Maikel P. Peppelenbosch & Gwenny M. Fuhler. (2010) Reversible phosphorylation in haematological malignancies: Potential role for protein tyrosine phosphatases in treatment?. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1806:2, pages 287-303.
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Stephen M. Keyse. 2010. Handbook of Cell Signaling. Handbook of Cell Signaling 755 769 .
Matthew Soulsby & Anton M. Bennett. (2009) Physiological Signaling Specificity by Protein Tyrosine Phosphatases. Physiology 24:5, pages 281-289.
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David A. Critton, Antoni Tortajada, Geoffrey Stetson, Wolfgang Peti & Rebecca Page. (2008) Structural Basis of Substrate Recognition by Hematopoietic Tyrosine Phosphatase,. Biochemistry 47:50, pages 13336-13345.
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Yuan-Yuan Zhang, Zi-Qing Mei, Jia-Wei Wu & Zhi-Xin Wang. (2008) Enzymatic Activity and Substrate Specificity of Mitogen-activated Protein Kinase p38α in Different Phosphorylation States. Journal of Biological Chemistry 283:39, pages 26591-26601.
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Jennifer A. Young, Amy M. Becker, Jennifer J. Medeiros, Virginia S. Shapiro, Andrew Wang, J. David Farrar, Timothy A. Quill, Rob Hooft van Huijsduijnen & Nicolai S.C. van Oers. (2008) The protein tyrosine phosphatase PTPN4/PTP-MEG1, an enzyme capable of dephosphorylating the TCR ITAMs and regulating NF-κB, is dispensable for T cell development and/or T cell effector functions. Molecular Immunology 45:14, pages 3756-3766.
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Kassim Traore, Rajni Sharma, Rajesh K. Thimmulappa, Walter H. Watson, Shyam Biswal & Michael A. Trush. (2008) Redox-regulation of Erk1/2-directed phosphatase by reactive oxygen species: Role in signaling TPA-induced growth arrest in ML-1 cells. Journal of Cellular Physiology 216:1, pages 276-285.
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Wiljan J. A. J. Hendriks, Ari Elson, Sheila Harroch & Andrew W. Stoker. (2008) Protein tyrosine phosphatases: functional inferences from mouse models and human diseases. FEBS Journal 275:5, pages 816-830.
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Amanda M. Opaluch, Pedro Aza-Blanc, Torkel Vang, Scott Williams, Lutz Tautz, Loribelle Milan & Tomas Mustelin. (2007) PTPome-wide functional RNA interference screening methods. Methods 42:3, pages 306-312.
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Jakub Abramson & Israel Pecht. (2007) Regulation of the mast cell response to the type 1 Fc? receptor. Immunological Reviews 217:1, pages 231-254.
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Renato G. S. Chirivi, Yvet E. Noordman, Catharina E. E. M. Van der Zee & Wiljan J. A. J. Hendriks. (2006) Altered MAP kinase phosphorylation and impaired motor coordination in PTPRR deficient mice. Journal of Neurochemistry 101:3, pages 829-840.
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Masaru Mitsushima, Kazumitsu Ueda & Noriyuki Kioka. (2007) Involvement of phosphatases in the anchorage-dependent regulation of ERK2 activation. Experimental Cell Research 313:9, pages 1830-1838.
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Lily I. PaoKaren BadourKatherine A. SiminovitchBenjamin G. Neel. (2007) Nonreceptor Protein-Tyrosine Phosphatases in Immune Cell Signaling. Annual Review of Immunology 25:1, pages 473-523.
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Tony Tiganis & Anton M. Bennett. (2007) Protein tyrosine phosphatase function: the substrate perspective. Biochemical Journal 402:1, pages 1-15.
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Alastair J. Barr & Stefan Knapp. (2006) MAPK-specific tyrosine phosphatases: new targets for drug discovery?. Trends in Pharmacological Sciences 27:10, pages 525-530.
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Jeyanthy EswaranJens Peter von Kries, Brian MarsdenEmma LongmanJudit É. DebreczeniEmilie UgochukwuAndrew TurnbullWen Hwa LeeStefan KnappAlastair J. Barr. (2006) Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases. Biochemical Journal 395:3, pages 483-491.
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Jun Cai, Wen G. Jiang, Asif Ahmed & Mike Boulton. (2006) Vascular endothelial growth factor-induced endothelial cell proliferation is regulated by interaction between VEGFR-2, SH-PTP1 and eNOS. Microvascular Research 71:1, pages 20-31.
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Tomas Mustelin. 2006. Lymphocyte Signal Transduction. Lymphocyte Signal Transduction 53 72 .
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Panu E. Kovanen, Lynn Young, Amin Al-Shami, Valentina Rovella, Cynthia A. Pise-Masison, Michael F. Radonovich, John Powell, Jacqueline Fu, John N. Brady, Peter J. Munson & Warren J. Leonard. (2005) Global analysis of IL-2 target genes: identification of chromosomal clusters of expressed genes. International Immunology 17:8, pages 1009-1021.
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Tomas Mustelin, Torkel Vang & Nunzio Bottini. (2005) Protein tyrosine phosphatases and the immune response. Nature Reviews Immunology 5:1, pages 43-57.
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Jakub Abramson & Israel Pecht. 2005. Biophysical Aspects of Transmembrane Signaling. Biophysical Aspects of Transmembrane Signaling 211 263 .
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Andrew E. Schade & Alan D. Levine. (2004) Cutting Edge: Extracellular Signal-Regulated Kinases 1/2 Function as Integrators of TCR Signal Strength. The Journal of Immunology 172:10, pages 5828-5832.
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David J. Pagliarini, Fred L. Robinson & Jack E. Dixon. 2004. Encyclopedia of Biological Chemistry. Encyclopedia of Biological Chemistry 536 542 .
Felix Rintelen, Ernst Hafen & Knud Nairz. (2003) The Drosophila dual-specificity ERK phosphatase DMKP3 cooperates with the ERK tyrosine phosphatase PTP-ER . Development 130:15, pages 3479-3490.
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S M Pettiford & R Herbst. (2003) The protein tyrosine phosphatase HePTP regulates nuclear translocation of ERK2 and can modulate megakaryocytic differentiation of K562 cells. Leukemia 17:2, pages 366-378.
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Tomas Mustelin, Souad Rahmouni, Nunzio Bottini & Andres Alonso. (2003) Role of protein tyrosine phosphatases in T cell activation. Immunological Reviews 191:1, pages 139-147.
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Jun Yang, Yingnian Yu & Penelope J Duerksen-Hughes. (2003) Protein kinases and their involvement in the cellular responses to genotoxic stress. Mutation Research/Reviews in Mutation Research 543:1, pages 31-58.
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Marco Muda & Steve Arkinstall. 2003. Handbook of Cell Signaling. Handbook of Cell Signaling 703 706 .
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Petr Heneberg & Petr Dráber. (2002) Nonreceptor Protein Tyrosine and Lipid Phosphatases in Type I Fcε Receptor-Mediated Activation of Mast Cells and Basophils. International Archives of Allergy and Immunology 128:4, pages 253-263.
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