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Mammalian Genetic Models with Minimal or Complex Phenotypes

Targeted Disruption of the Myocilin Gene (Myoc) Suggests that Human Glaucoma-Causing Mutations Are Gain of Function

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Pages 7707-7713 | Received 04 Apr 2001, Accepted 06 Aug 2001, Published online: 28 Mar 2023

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Timothy E. Yap, Eduardo M. Normando & Maria Francesca Cordeiro. (2018) Redefining clinical outcomes and endpoints in glaucoma. Expert Review of Ophthalmology 13:2, pages 113-127.
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Susan Eileen Isabella Williams, Trevor Robin Carmichael, Tasha Wainstein, Angela Hobbs & Michele Ramsay. (2015) MYOC Mutations in Black South African Patients with Primary Open-angle Glaucoma: Genetic Testing and Cascade Screening. Ophthalmic Genetics 36:1, pages 31-38.
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Bernd Rautenstrauss & Christian Mardin. (2010) Targeting glaucoma beyond intraocular pressure. Expert Review of Ophthalmology 5:2, pages 217-224.
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Heung-Sun Kwon, Hee-Sheung Lee, Yun Ji, Jeffrey S. Rubin & Stanislav I. Tomarev. (2009) Myocilin Is a Modulator of Wnt Signaling. Molecular and Cellular Biology 29:8, pages 2139-2154.
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Angela V. Turalba & Teresa C. Chen. (2008) Clinical and Genetic Characteristics of Primary Juvenile-Onset Open-Angle Glaucoma (JOAG). Seminars in Ophthalmology 23:1, pages 19-25.
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Douglas B. Gould, Mark Reedy, Lawriston A. Wilson, Richard S. Smith, Randy L. Johnson & Simon W. M. John. (2006) Mutant Myocilin Nonsecretion In Vivo Is Not Sufficient To Cause Glaucoma. Molecular and Cellular Biology 26:22, pages 8427-8436.
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Douglas B. Gould, Laura Miceli-Libby, Olga V. Savinova, Mario Torrado, Stanislav I. Tomarev, Richard S. Smith & Simon W. M. John. (2004) Genetically Increasing Myoc Expression Supports a Necessary Pathologic Role of Abnormal Proteins in Glaucoma. Molecular and Cellular Biology 24:20, pages 9019-9025.
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Iok-Hou Pang & Abbot F Clark. (2002) Advances in glaucoma therapeutics. Expert Opinion on Emerging Drugs 7:1, pages 141-163.
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