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Molecular and Cellular Biology Volume 21, 2001 - Issue 22
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DNA Dynamics and Chromosome Structure

N-Terminal Domains of the Human Telomerase Catalytic Subunit Required for Enzyme Activity in Vivo

Blaine N. ArmbrusterDepartment of Pharmacology and Cancer Biology, Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina27710
,
Soma S. R. BanikDepartment of Pharmacology and Cancer Biology, Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina27710
,
Chuanhai GuoDepartment of Pharmacology and Cancer Biology, Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina27710
,
Allyson C. SmithDepartment of Pharmacology and Cancer Biology, Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina27710
&
Christopher M. CounterDepartment of Pharmacology and Cancer Biology, Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina27710Correspondence[email protected]
Pages 7775-7786 | Received 01 May 2001, Accepted 07 Aug 2001, Published online: 28 Mar 2023

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Alexandra M. Pike, Margaret A. Strong, John Paul T. Ouyang & Carol W. Greider. (2019) TIN2 Functions with TPP1/POT1 To Stimulate Telomerase Processivity. Molecular and Cellular Biology 39:21.
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Tsz Wai Chu, Yasmin D'Souza & Chantal Autexier. (2016) The Insertion in Fingers Domain in Human Telomerase Can Mediate Enzyme Processivity and Telomerase Recruitment to Telomeres in a TPP1-Dependent Manner. Molecular and Cellular Biology 36:1, pages 210-222.
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Katharine S. Barrientos, Megan F. Kendellen, Brian D. Freibaum, Blaine N. Armbruster, Katherine T. Etheridge & Christopher M. Counter. (2008) Distinct Functions of POT1 at Telomeres . Molecular and Cellular Biology 28:17, pages 5251-5264.
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Haley D. M. Wyatt, Deirdre A. Lobb & Tara L. Beattie. (2007) Characterization of Physical and Functional Anchor Site Interactions in Human Telomerase. Molecular and Cellular Biology 27:8, pages 3226-3240.
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Elaine J. Middleman, Jinkuk Choi, Andrew S. Venteicher, Peggie Cheung & Steven E. Artandi. (2006) Regulation of Cellular Immortalization and Steady-State Levels of the Telomerase Reverse Transcriptase through Its Carboxy-Terminal Domain. Molecular and Cellular Biology 26:6, pages 2146-2159.
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Hong Ji, Margaret H. Platts, Latif M. Dharamsi & Katherine L. Friedman. (2005) Regulation of Telomere Length by an N-Terminal Region of the Yeast Telomerase Reverse Transcriptase. Molecular and Cellular Biology 25:20, pages 9103-9114.
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Tara J. Moriarty, Delphine T. Marie-Egyptienne & Chantal Autexier. (2004) Functional Organization of Repeat Addition Processivity and DNA Synthesis Determinants in the Human Telomerase Multimer. Molecular and Cellular Biology 24:9, pages 3720-3733.
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Blaine N. Armbruster, Corinne M. Linardic, Tim Veldman, Niharika P. Bansal, Diane L. Downie & Christopher M. Counter. (2004) Rescue of an hTERT Mutant Defective in Telomere Elongation by Fusion with hPot1. Molecular and Cellular Biology 24:8, pages 3552-3561.
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Blaine N. Armbruster, Katherine T. Etheridge, Dominique Broccoli & Christopher M. Counter. (2003) Putative Telomere-Recruiting Domain in the Catalytic Subunit of Human Telomerase. Molecular and Cellular Biology 23:9, pages 3237-3246.
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Soma S. R. Banik, Chuanhai Guo, Allyson C. Smith, Seth S. Margolis, D. Ashley Richardson, Carlos A. Tirado & Christopher M. Counter. (2002) C-Terminal Regions of the Human Telomerase Catalytic Subunit Essential for In Vivo Enzyme Activity. Molecular and Cellular Biology 22:17, pages 6234-6246.
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Tara J. Moriarty, Sylvain Huard, Sophie Dupuis & Chantal Autexier. (2002) Functional Multimerization of Human Telomerase Requires an RNA Interaction Domain in the N Terminus of the Catalytic Subunit. Molecular and Cellular Biology 22:4, pages 1253-1265.
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Deanna MacNeil, Hélène Bensoussan & Chantal Autexier. (2016) Telomerase Regulation from Beginning to the End. Genes 7:9, pages 64.
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Robert Alexander Wu, Yavuz S Dagdas, S Tunc Yilmaz, Ahmet Yildiz & Kathleen Collins. (2015) Single-molecule imaging of telomerase reverse transcriptase in human telomerase holoenzyme and minimal RNP complexes. eLife 4.
Crossref
H. Gong, W. Zhu, J. Zhang, X. Li, Q. Meng, G. Zhou, M. Wang, H. Wang, L. Miao, Q. Qin & H. Zhang. (2015) TTAGG-repeat telomeres and characterization of telomerase in the beet armyworm, Spodoptera exigua (Lepidoptera: Noctuidae) . Insect Molecular Biology 24:3, pages 358-367.
Crossref
Jens C. Schmidt & Thomas R. Cech. (2015) Human telomerase: biogenesis, trafficking, recruitment, and activation. Genes & Development 29:11, pages 1095-1105.
Crossref
Elton J. R. Vasconcelos, Vinícius S. Nunes, Marcelo S. da Silva, Marcela Segatto, Peter J. Myler & Maria Isabel N. Cano. (2014) The Putative Leishmania Telomerase RNA (LeishTER) Undergoes Trans-Splicing and Contains a Conserved Template Sequence. PLoS ONE 9:11, pages e112061.
Crossref
Jens C Schmidt, Andrew B Dalby & Thomas R Cech. (2014) Identification of human TERT elements necessary for telomerase recruitment to telomeres. eLife 3.
Crossref
Shusen Zhu, Philippe Rousseau, Catherine Lauzon, Valentina Gandin, Ivan Topisirovic & Chantal Autexier. (2014) Inactive C-terminal telomerase reverse transcriptase insertion splicing variants are dominant-negative inhibitors of telomerase. Biochimie 101, pages 93-103.
Crossref
Cornelia Frohnert, Saskia Hutten, Sarah Wälde, Annegret Nath & Ralph H. Kehlenbach. (2014) Importin 7 and Nup358 Promote Nuclear Import of the Protein Component of Human Telomerase. PLoS ONE 9:2, pages e88887.
Crossref
Miriam Aparecida Giardini, Marcela Segatto, Marcelo Santos da Silva, Vinícius Santana Nunes & Maria Isabel Nogueira Cano. 2014. Telomeres in Health and Disease. Telomeres in Health and Disease 1 40 .
Jerry W Shay. 2001. eLS. eLS.
Kyle R. Hukezalie & Judy M. Y. Wong. (2013) Structure-function relationship and biogenesis regulation of the human telomerase holoenzyme. FEBS Journal 280:14, pages 3194-3204.
Crossref
Yasmin D'Souza, Tsz Wai Chu & Chantal Autexier. (2013) A translocation-defective telomerase with low levels of activity and processivity stabilizes short telomeres and confers immortalization. Molecular Biology of the Cell 24:9, pages 1469-1479.
Crossref
Meng He, Wei-Chou Tseng & Vann Bennett. (2013) A Single Divergent Exon Inhibits Ankyrin-B Association with the Plasma Membrane. Journal of Biological Chemistry 288:21, pages 14769-14779.
Crossref
Jiansen Jiang, Edward J. Miracco, Kyungah Hong, Barbara Eckert, Henry Chan, Darian D. Cash, Bosun Min, Z. Hong Zhou, Kathleen Collins & Juli Feigon. (2013) The architecture of Tetrahymena telomerase holoenzyme. Nature 496:7444, pages 187-192.
Crossref
Benjamin J Ritchie, William C Smolski, Ellyn R Montgomery, Elizabeth S Fisher, Tina Y Choi, Calla M Olson, Lori A Foster & Thomas E Meigs. (2013) Determinants at the N- and C-termini of Gα<sub>12</sub> required for activation of Rho-mediated signaling. Journal of Molecular Signaling 8, pages 3.
Crossref
Jayakrishnan Nandakumar & Thomas R. Cech. (2013) Finding the end: recruitment of telomerase to telomeres. Nature Reviews Molecular Cell Biology 14:2, pages 69-82.
Crossref
Lifeng Xu, Shang Li & Bradley A. Stohr. (2013) The Role of Telomere Biology in Cancer. Annual Review of Pathology: Mechanisms of Disease 8:1, pages 49-78.
Crossref
Yasmin D'Souza, Catherine Lauzon, Tsz Wai Chu & Chantal Autexier. (2013) Regulation of telomere length and homeostasis by telomerase enzyme processivity. Journal of Cell Science 126:2, pages 676-687.
Crossref
Raina A. Tamakawa, Helen B. Fleisig & Judy M. Y. Wong. 2013. Advances in DNA Repair in Cancer Therapy. Advances in DNA Repair in Cancer Therapy 229 279 .
Johanna B. Withers, Tamara Ashvetiya & Karen L. Beemon. (2012) Exclusion of Exon 2 Is a Common mRNA Splice Variant of Primate Telomerase Reverse Transcriptases. PLoS ONE 7:10, pages e48016.
Crossref
Alec N. Sexton, Daniel T. Youmans & Kathleen Collins. (2012) Specificity Requirements for Human Telomere Protein Interaction with Telomerase Holoenzyme. Journal of Biological Chemistry 287:41, pages 34455-34464.
Crossref
Momchil D. Vodenicharov & Raymund J. Wellinger. 2012. Telomerases. Telomerases 157 199 .
Barbara Eckert & Kathleen Collins. (2012) Roles of Telomerase Reverse Transcriptase N-terminal Domain in Assembly and Activity of Tetrahymena Telomerase Holoenzyme. Journal of Biological Chemistry 287:16, pages 12805-12814.
Crossref
H B Fleisig & J M Y Wong. (2011) Telomerase promotes efficient cell cycle kinetics and confers growth advantage to telomerase-negative transformed human cells. Oncogene 31:8, pages 954-965.
Crossref
Shibani Mukherjee, Eduardo J. Firpo, Yang Wang & James M. Roberts. (2011) Separation of telomerase functions by reverse genetics. Proceedings of the National Academy of Sciences 108:50.
Crossref
David CF Sealey, Aleksandar D Kostic, Catherine LeBel, Fiona Pryde & Lea Harrington. (2011) The TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasis. BMC Molecular Biology 12:1.
Crossref
Craig Nicholls, He Li, Jian-Qiu Wang & Jun-Ping Liu. (2011) Molecular regulation of telomerase activity in aging. Protein & Cell 2:9, pages 726-738.
Crossref
Aaron R. Robart & Kathleen Collins. (2011) Human Telomerase Domain Interactions Capture DNA for TEN Domain-Dependent Processive Elongation. Molecular Cell 42:3, pages 308-318.
Crossref
Megan Moerdyk-Schauwecker, Darla DeStephanis, Eric Hastie & Valery Z. Grdzelishvili. (2011) Detecting protein–protein interactions in vesicular stomatitis virus using a cytoplasmic yeast two hybrid system. Journal of Virological Methods 173:2, pages 203-212.
Crossref
Daniel Hartmann, Ujala Srivastava, Michaela Thaler, Karin N. Kleinhans, Gisèle N'Kontchou, Annika Scheffold, Kerstin Bauer, Ramona F. Kratzer, Natalia Kloos, Sarah-Fee Katz, Zhangfa Song, Yvonne Begus-Nahrmann, Alexander Kleger, Guido von Figura, Pavel Strnad, André Lechel, Cagatay Günes, Andrej Potthoff, Katja Deterding, Heiner Wedemeyer, Zhenyu Ju, Ge Song, Feng Xiao, Sonja Gillen, Hubert Schrezenmeier, Thomas Mertens, Marianne Ziol, Helmut Friess, Michael Jarek, Michael P. Manns, Michel Beaugrand & K. Lenhard Rudolph. (2011) Telomerase gene mutations are associated with cirrhosis formation. Hepatology 53:5, pages 1608-1617.
Crossref
Erik R. WestinNukhet Aykin-BurnsErin M. BuckinghamDouglas R. SpitzFrederick D. GoldmanAloysius J. Klingelhutz. (2011) The p53/p21 WAF/CIP Pathway Mediates Oxidative Stress and Senescence in Dyskeratosis Congenita Cells with Telomerase Insufficiency . Antioxidants & Redox Signaling 14:6, pages 985-997.
Crossref
Julie Jurczyluk, Amanda S. Nouwens, Jessica K. Holien, Timothy E. Adams, George O. Lovrecz, Michael W. Parker, Scott B. Cohen & Tracy M. Bryan. (2011) Direct involvement of the TEN domain at the active site of human telomerase. Nucleic Acids Research 39:5, pages 1774-1788.
Crossref
M. I. Zvereva, D. M. Shcherbakova & O. A. Dontsova. (2011) Telomerase: Structure, functions, and activity regulation. Biochemistry (Moscow) 75:13, pages 1563-1583.
Crossref
Johans Fakhoury, Delphine Tamara Marie-Egyptienne, José-Arturo Londoño-Vallejo & Chantal Autexier. (2010) Telomeric function of mammalian telomerases at short telomeres. Journal of Cell Science 123:10, pages 1693-1704.
Crossref
Olga A. Kovalenko, Matthieu J. Caron, Perihan Ulema, Carolina Medrano, Andrew P. Thomas, Masayuki Kimura, Marcelo G. Bonini, Utz Herbig & Janine H. Santos. (2010) A mutant telomerase defective in nuclear-cytoplasmic shuttling fails to immortalize cells and is associated with mitochondrial dysfunction. Aging Cell 9:2, pages 203-219.
Crossref
David C. F. Sealey, Le Zheng, Michael A. S. Taboski, Jennifer Cruickshank, Mitsuhiko Ikura & Lea A. Harrington. (2010) The N-terminus of hTERT contains a DNA-binding domain and is required for telomerase activity and cellular immortalization. Nucleic Acids Research 38:6, pages 2019-2035.
Crossref
Arthur J. Zaug, Elaine R. Podell, Jayakrishnan Nandakumar & Thomas R. Cech. (2010) Functional interaction between telomere protein TPP1 and telomerase. Genes & Development 24:6, pages 613-622.
Crossref
Donna M. Gordon & Janine Hertzog Santos. (2010) The Emerging Role of Telomerase Reverse Transcriptase in Mitochondrial DNA Metabolism. Journal of Nucleic Acids 2010, pages 1-7.
Crossref
Stephen Kearsey, Judith L Campbell, Genevieve Almouzni, Joanna Poulton, Takehiro Yasukawa, Steve Bell, Ron Laskey, Tom Kunkel, James Chong, Xinquan Ge, Julian Blow, Christian Speck, Ginger Jiang, Ellen Fanning, Helle D Ulrich, Christian Haering, James Chong, Ji-Liang Li, Tracy Bryan & Alison WaltersTracy M. Bryan. 2009. Molecular Themes in DNA Replication. Molecular Themes in DNA Replication 217 268 .
Zhaochun Wu, Bin Zhang & Bing Yan. (2009) Regulation of Enzyme Activity through Interactions with Nanoparticles. International Journal of Molecular Sciences 10:10, pages 4198-4209.
Crossref
Eva Sýkorová & Jiří Fajkus. (2009) Structure-function relationships in telomerase genes. Biology of the Cell 101:7, pages 375-406.
Crossref
Brooke Dancho, Margie O. McKenzie, John H. Connor & Douglas S. Lyles. (2009) Vesicular Stomatitis Virus Matrix Protein Mutations That Affect Association with Host Membranes and Viral Nucleocapsids. Journal of Biological Chemistry 284:7, pages 4500-4509.
Crossref
Kathleen Collins. 2009. Non-Protein Coding RNAs. Non-Protein Coding RNAs 285 301 .
Shintaro Imamura, Junzo Uchiyama, Eriko Koshimizu, Jun-ichi Hanai, Christina Raftopoulou, Ryan D. Murphey, Peter E. Bayliss, Yoichi Imai, Caroline Erter Burns, Kenkichi Masutomi, Sarantis Gagos, Leonard I. Zon, Thomas M. Roberts & Shuji Kishi. (2008) A Non-Canonical Function of Zebrafish Telomerase Reverse Transcriptase Is Required for Developmental Hematopoiesis. PLoS ONE 3:10, pages e3364.
Crossref
Brian D. Freibaum & Christopher M. Counter. (2008) The Protein hSnm1B Is Stabilized When Bound to the Telomere-binding Protein TRF2. Journal of Biological Chemistry 283:35, pages 23671-23676.
Crossref
Alessandro Bianchi & David Shore. (2008) How Telomerase Reaches Its End: Mechanism of Telomerase Regulation by the Telomeric Complex. Molecular Cell 31:2, pages 153-165.
Crossref
David Alves, Haitao Li, Rosalind Codrington, Angel Orte, Xiaojun Ren, David Klenerman & Shankar Balasubramanian. (2008) Single-molecule analysis of human telomerase monomer. Nature Chemical Biology 4:5, pages 287-289.
Crossref
Sharon N. Finger & Tracy M. Bryan. (2008) Multiple DNA-binding sites in Tetrahymena telomerase. Nucleic Acids Research 36:4, pages 1260-1272.
Crossref
Katherine T. Etheridge, Sarah A. Compton, Katharine S. Barrientos, Sezgin Ozgur, Jack D. Griffith & Christopher M. Counter. (2008) Tethering Telomeric Double- and Single-stranded DNA-binding Proteins Inhibits Telomere Elongation. Journal of Biological Chemistry 283:11, pages 6935-6941.
Crossref
Kathleen Collins. (2008) Physiological assembly and activity of human telomerase complexes. Mechanisms of Ageing and Development 129:1-2, pages 91-98.
Crossref
Hong-Yan Du, Monica Bessler & Philip J. Mason. 2008. Telomeres and Telomerase in Ageing, Disease, and Cancer. Telomeres and Telomerase in Ageing, Disease, and Cancer 77 107 .
Sophie Redon, Patrick Reichenbach & Joachim Lingner. (2007) Protein–RNA and protein–protein interactions mediate association of human EST1A/SMG6 with telomerase. Nucleic Acids Research 35:20, pages 7011-7022.
Crossref
Yang Li, Joel A. Yates & Julian J.-L. Chen. (2007) Identification and characterization of sea squirt telomerase reverse transcriptase. Gene 400:1-2, pages 16-24.
Crossref
Blaine N. ArmbrusterXiang Li, Mark H. Pausch, Stefan Herlitze & Bryan L. Roth. (2007) Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand. Proceedings of the National Academy of Sciences 104:12, pages 5163-5168.
Crossref
S J Adam, L A Rund, K N Kuzmuk, J F Zachary, L B Schook & C M Counter. (2006) Genetic induction of tumorigenesis in Swine. Oncogene 26:7, pages 1038-1045.
Crossref
Chang-Cheng You, Sarit S. Agasti, Mrinmoy De, Michael J. Knapp & Vincent M. Rotello. (2006) Modulation of the Catalytic Behavior of α-Chymotrypsin at Monolayer-Protected Nanoparticle Surfaces. Journal of the American Chemical Society 128:45, pages 14612-14618.
Crossref
Jason D. Legassie & Michael B. Jarstfer. (2006) The Unmasking of Telomerase. Structure 14:11, pages 1603-1609.
Crossref
Maria Antonietta Cerone & Silvia Bacchetti. 2006. Encyclopedia of Molecular Cell Biology and Molecular Medicine. Encyclopedia of Molecular Cell Biology and Molecular Medicine.
Ying-Li Wu, Charles Dudognon, Eric Nguyen, Josette Hillion, Frédéric Pendino, Ilona Tarkanyi, Janos Aradi, Michel Lanotte, Jian-Hua Tong, Guo-Qiang Chen & Evelyne Ségal-Bendirdjian. (2006) Immunodetection of human telomerase reverse-transcriptase (hTERT) re-appraised: nucleolin and telomerase cross paths. Journal of Cell Science 119:13, pages 2797-2806.
Crossref
D. M. Shcherbakova, M. E. Zvereva, O. V. Shpanchenko & O. A. Dontsova. (2006) Telomerase: Structure and properties of the enzyme, and peculiarities of yeast telomerase. Molecular Biology 40:4, pages 514-527.
Crossref
Kathleen Collins. (2006) The biogenesis and regulation of telomerase holoenzymes. Nature Reviews Molecular Cell Biology 7:7, pages 484-494.
Crossref
Rebecca A. Mosher, Wendy E. Durrant, Dong Wang, Junqi Song & Xinnian Dong. (2006) A Comprehensive Structure–Function Analysis of Arabidopsis SNI1 Defines Essential Regions and Transcriptional Repressor Activity . The Plant Cell 18:7, pages 1750-1765.
Crossref
Amir Goldkorn & Elizabeth H. Blackburn. (2006) Assembly of Mutant-Template Telomerase RNA into Catalytically Active Telomerase Ribonucleoprotein That Can Act on Telomeres Is Required for Apoptosis and Cell Cycle Arrest in Human Cancer Cells. Cancer Research 66:11, pages 5763-5771.
Crossref
Chantal AutexierNeal F. Lue. (2006) The Structure and Function of Telomerase Reverse Transcriptase. Annual Review of Biochemistry 75:1, pages 493-517.
Crossref
Janine Hertzog Santos, Joel N. Meyer & Bennett Van Houten. (2006) Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis. Human Molecular Genetics 15:11, pages 1757-1768.
Crossref
Miriam A. Giardini, Cristina B. B. Lira, Fábio F. Conte, Luciana R. Camillo, Jair L. de Siqueira Neto, Carlos H. I. Ramos & Maria Isabel N. Cano. (2006) The putative telomerase reverse transcriptase component of Leishmania amazonensis: gene cloning and characterization. Parasitology Research 98:5, pages 447-454.
Crossref
Steven A Jacobs, Elaine R Podell & Thomas R Cech. (2006) Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase. Nature Structural & Molecular Biology 13:3, pages 218-225.
Crossref
Bettina Meier, Iuval Clejan, Yan Liu, Mia Lowden, Anton Gartner, Jonathan Hodgkin & Shawn Ahmed. (2006) trt-1 Is the Caenorhabditis elegans Catalytic Subunit of Telomerase. PLoS Genetics 2:2, pages e18.
Crossref
Nathaniel J Hansen, Joseph C Poole, Lucy G Andrews & Trygve O Tollefsbol. 2001. eLS. eLS.
Maria A Cerone, Chantal Autexier, J Arturo Londoño-Vallejo & Silvia Bacchetti. (2005) A human cell line that maintains telomeres in the absence of telomerase and of key markers of ALT. Oncogene 24:53, pages 7893-7901.
Crossref
TARA J. MORIARTY, DELPHINE T. MARIE-EGYPTIENNE & CHANTAL AUTEXIER. (2005) Regulation of 5′ template usage and incorporation of noncognate nucleotides by human telomerase. RNA 11:9, pages 1448-1460.
Crossref
Steven A. Jacobs, Elaine R. Podell, Deborah S. Wuttke & Thomas R. Cech. (2005) Soluble domains of telomerase reverse transcriptase identified by high-throughput screening. Protein Science 14:8, pages 2051-2058.
Crossref
Tara J. Moriarty, Ryan J. Ward, Michael A.S. Taboski & Chantal Autexier. (2005) An Anchor Site–Type Defect in Human Telomerase That Disrupts Telomere Length Maintenance and Cellular Immortalization. Molecular Biology of the Cell 16:7, pages 3152-3161.
Crossref
Neal F. Lue. (2005) A Physical and Functional Constituent of Telomerase Anchor Site. Journal of Biological Chemistry 280:28, pages 26586-26591.
Crossref
Wai Ho Yap, Elizabeth Yeoh, Sydney Brenner & Byrappa Venkatesh. (2005) Cloning and expression of the reverse transcriptase component of pufferfish (Fugu rubripes) telomerase. Gene 353:2, pages 207-217.
Crossref
Kenkichi MasutomiRichard PossematoJudy M. Y. WongJennifer L. CurrierZuzana TothovaJudith B. ManolaShridar GanesanPeter M. LansdorpKathleen CollinsWilliam C. Hahn. (2005) The telomerase reverse transcriptase regulates chromatin state and DNA damage responses. Proceedings of the National Academy of Sciences 102:23, pages 8222-8227.
Crossref
Thomas E. Meigs, Juhi Juneja, C. Todd DeMarco, Laura N. Stemmle, Daniel D. Kaplan & Patrick J. Casey. (2005) Selective Uncoupling of Gα12 from Rho-mediated Signaling. Journal of Biological Chemistry 280:18, pages 18049-18055.
Crossref
Carolyn K. Dong, Kenkichi Masutomi & William C. Hahn. (2005) Telomerase: regulation, function and transformation. Critical Reviews in Oncology/Hematology 54:2, pages 85-93.
Crossref
Tom J. Vulliamy, Amanda Walne, Aroon Baskaradas, Philip J. Mason, Anna Marrone & Inderjeet Dokal. (2005) Mutations in the reverse transcriptase component of telomerase (TERT) in patients with bone marrow failure. Blood Cells, Molecules, and Diseases 34:3, pages 257-263.
Crossref
Hiroki Yamaguchi, Rodrigo T. Calado, Hinh Ly, Sachiko Kajigaya, Gabriela M. Baerlocher, Stephen J. Chanock, Peter M. Lansdorp & Neal S. Young. (2005) Mutations in TERT, the Gene for Telomerase Reverse Transcriptase, in Aplastic Anemia . New England Journal of Medicine 352:14, pages 1413-1424.
Crossref
Janine Hertzog Santos, Joel N. Meyer, Milan Skorvaga, Lois A. Annab & Bennett Van Houten. (2004) Mitochondrial hTERT exacerbates free-radical-mediated mtDNA damage. Aging Cell 3:6, pages 399-411.
Crossref
Soma S.R. Banik & Christopher M. Counter. (2004) Characterization of Interactions between PinX1 and Human Telomerase Subunits hTERT and hTR. Journal of Biological Chemistry 279:50, pages 51745-51748.
Crossref
Shilagardi Khurts, Kenkichi Masutomi, Luvsanjav Delgermaa, Kuniaki Arai, Naoki Oishi, Hideki Mizuno, Naoyuki Hayashi, William C. Hahn & Seishi Murakami. (2004) Nucleolin Interacts with Telomerase. Journal of Biological Chemistry 279:49, pages 51508-51515.
Crossref
Timothy Veldman, Katherine T. Etheridge & Christopher M. Counter. (2004) Loss of hPot1 Function Leads to Telomere Instability and a cut-like Phenotype. Current Biology 14:24, pages 2264-2270.
Crossref
Lubna Nasir, Elizabeth Gault, Sarah Campbell, Mallika Veeramalai, David Gilbert, Robert McFarlane, Alison Munro & David J Argyle. (2004) Isolation and expression of the reverse transcriptase component of the Canis familiaris telomerase ribonucleoprotein (dogTERT). Gene 336:1, pages 105-113.
Crossref
Dominique Broccoli. (2004) Function, replication and structure of the mammalian telomere. Cytotechnology 45:1-2, pages 3-12.
Crossref
Mitchel Seruya, Anup Shah, Dawn Pedrotty, Tracey Du Laney, Ryan Melgiri, J. Andrew Mckee, Henry E. Young & Laura E. Niklason. (2017) Clonal Population of Adult Stem Cells: Life Span and Differentiation Potential. Cell Transplantation 13:2, pages 93-101.
Crossref
Jue Lin & Elizabeth H. Blackburn. (2004) Nucleolar protein PinX1p regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNA. Genes & Development 18:4, pages 387-396.
Crossref
Tracy M. Bryan, Karen J. Goodrich & Thomas R. Cech. (2003) Tetrahymena Telomerase Is Active as a Monomer . Molecular Biology of the Cell 14:12, pages 4794-4804.
Crossref
Suzanne R. Lee, Judy M.Y. Wong & Kathleen Collins. (2003) Human Telomerase Reverse Transcriptase Motifs Required for Elongation of a Telomeric Substrate. Journal of Biological Chemistry 278:52, pages 52531-52536.
Crossref
Leticia R. Vega, Maria K. Mateyak & Virginia A. Zakian. (2003) Getting to the end: telomerase access in yeast and humans. Nature Reviews Molecular Cell Biology 4:12, pages 948-959.
Crossref
J Andrew McKee, Soma SR Banik, Matthew J Boyer, Nesrin M Hamad, Jeffrey H Lawson, Laura E Niklason & Christopher M Counter. (2003) Human arteries engineered in vitro . EMBO reports 4:6, pages 633-638.
Crossref
William C. Hahn. (2003) Role of Telomeres and Telomerase in the Pathogenesis of Human Cancer. Journal of Clinical Oncology 21:10, pages 2034-2043.
Crossref
Lea Harrington. (2003) Biochemical aspects of telomerase function. Cancer Letters 194:2, pages 139-154.
Crossref
Christopher M Counter, William Press & Carolyn C Compton. (2003) Telomere shortening in cultured autografts of patients with burns. The Lancet 361:9366, pages 1345-1346.
Crossref
Dimitry Bosoy, Yun Peng, I. Saira Mian & Neal F. Lue. (2003) Conserved N-terminal Motifs of Telomerase Reverse Transcriptase Required for Ribonucleoprotein Assembly in Vivo. Journal of Biological Chemistry 278:6, pages 3882-3890.
Crossref
Katherine L. FriedmanJeremy J. Heit, David M. Long & Thomas R. Cech. (2003) N-terminal Domain of Yeast Telomerase Reverse Transcriptase: Recruitment of Est3p to the Telomerase Complex. Molecular Biology of the Cell 14:1, pages 1-13.
Crossref
Colleen Kelleher, M.Teresa Teixeira, Klaus Förstemann & Joachim Lingner. (2002) Telomerase: biochemical considerations for enzyme and substrate. Trends in Biochemical Sciences 27:11, pages 572-579.
Crossref
Nesrin M Hamad, Soma SR Banik & Christopher M Counter. (2002) Mutational analysis defines a minimum level of telomerase activity required for tumourigenic growth of human cells. Oncogene 21:46, pages 7121-7125.
Crossref
Yu-Sheng Cong, Woodring E. Wright & Jerry W. Shay. (2002) Human Telomerase and Its Regulation. Microbiology and Molecular Biology Reviews 66:3, pages 407-425.
Crossref
Nesrin M. Hamad, Joel H. Elconin, Antoine E. Karnoub, Wenli Bai, Jeremy N. Rich, Robert T. Abraham, Channing J. Der & Christopher M. Counter. (2002) Distinct requirements for Ras oncogenesis in human versus mouse cells. Genes & Development 16:16, pages 2045-2057.
Crossref
Katherine T. Etheridge, Soma S.R. Banik, Blaine N. Armbruster, Yusheng Zhu, Rebecca M. Terns, Michael P. Terns & Christopher M. Counter. (2002) The Nucleolar Localization Domain of the Catalytic Subunit of Human Telomerase. Journal of Biological Chemistry 277:27, pages 24764-24770.
Crossref
Katarzyna Heller-Uszynska, Wendelin Schnippenkoetter & Andrzej Kilian. (2002) Cloning and characterization of rice ( Oryza sativa L) telomerase reverse transcriptase, which reveals complex splicing patterns . The Plant Journal 31:1, pages 75-86.
Crossref
Yinhua Yang, Yaohui Chen, Chunyu Zhang, Hai Huang & Sherman M. Weissman. (2002) Nucleolar Localization of hTERT Protein Is Associated with Telomerase Function. Experimental Cell Research 277:2, pages 201-209.
Crossref
. (2002) Anti-Aging Medicine LiteratureWatch. Journal of Anti-Aging Medicine 5:1, pages 121-139.
Crossref
Kuniaki Arai, Kenkichi Masutomi, Shilagardy Khurts, Shuichi Kaneko, Kenichi Kobayashi & Seishi Murakami. (2002) Two Independent Regions of Human Telomerase Reverse Transcriptase Are Important for Its Oligomerization and Telomerase Activity. Journal of Biological Chemistry 277:10, pages 8538-8544.
Crossref
Kathleen Collins & James R Mitchell. (2002) Telomerase in the human organism. Oncogene 21:4, pages 564-579.
Crossref

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