5
Views
56
CrossRef citations to date
0
Altmetric
DNA Dynamics and Chromosome Structure

The Chinese Hamster Dihydrofolate Reductase Replication Origin Beta Is Active at Multiple Ectopic Chromosomal Locations and Requires Specific DNA Sequence Elements for Activity

&
Pages 1098-1110 | Received 24 Aug 2000, Accepted 16 Nov 2000, Published online: 28 Mar 2023

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (14)

Gennady Kholodii, Olga Dantsevich & Vyacheslav Tarantul. (2012) Transfecting DNA is frequently inserted near DNA replication origins. Cell Cycle 11:15, pages 2956-2958.
Read now
Maloy Ghosh, Michael Kemp, Guoqi Liu, Marion Ritzi, Aloys Schepers & Michael Leffak. (2006) Differential Binding of Replication Proteins across the Human c-myc Replicator. Molecular and Cellular Biology 26:14, pages 5270-5283.
Read now
Rebecca K. Rowntree & Jeannie T. Lee. (2006) Mapping of DNA Replication Origins to Noncoding Genes of the X-Inactivation Center. Molecular and Cellular Biology 26:10, pages 3707-3717.
Read now
Jindong Wang, Scott E. Lindner, Elizabeth R. Leight & Bill Sugden. (2006) Essential Elements of a Licensed, Mammalian Plasmid Origin of DNA Synthesis. Molecular and Cellular Biology 26:3, pages 1124-1134.
Read now
M. Ghosh, G. Liu, G. Randall, J. Bevington & M. Leffak. (2004) Transcription Factor Binding and Induced Transcription Alter Chromosomal c-myc Replicator Activity. Molecular and Cellular Biology 24:23, pages 10193-10207.
Read now
Lixin Wang, Chii-Mei Lin, Sarah Brooks, Dan Cimbora, Mark Groudine & Mirit I. Aladjem. (2004) The Human β-Globin Replication Initiation Region Consists of Two Modular Independent Replicators. Molecular and Cellular Biology 24:8, pages 3373-3386.
Read now
Sónia Paixão, Ivan N. Colaluca, Matthieu Cubells, Fiorenzo A. Peverali, Annarita Destro, Sara Giadrossi, Mauro Giacca, Arturo Falaschi, Silvano Riva & Giuseppe Biamonti. (2004) Modular Structure of the Human Lamin B2 Replicator. Molecular and Cellular Biology 24:7, pages 2958-2967.
Read now
Guoqi Liu, Michelle Malott & Michael Leffak. (2003) Multiple Functional Elements Comprise a Mammalian Chromosomal Replicator. Molecular and Cellular Biology 23:5, pages 1832-1842.
Read now
L. D. Mesner, X. Li, P. A. Dijkwel & J. L. Hamlin. (2003) The Dihydrofolate Reductase Origin of Replication Does Not Contain Any Nonredundant Genetic Elements Required for Origin Activity. Molecular and Cellular Biology 23:3, pages 804-814.
Read now
Victoria V. Lunyak, Michael Ezrokhi, Heidi S. Smith & Susan A. Gerbi. (2002) Developmental Changes in the Sciara II/9A Initiation Zone for DNA Replication. Molecular and Cellular Biology 22:24, pages 8426-8437.
Read now
Cong-Jun Li & Melvin L. DePamphilis. (2002) Mammalian Orc1 Protein Is Selectively Released from Chromatin and Ubiquitinated during the S-to-M Transition in the Cell Division Cycle. Molecular and Cellular Biology 22:1, pages 105-116.
Read now
Daochun Kong & Melvin L. DePamphilis. (2001) Site-Specific DNA Binding of the Schizosaccharomyces pombe Origin Recognition Complex Is Determined by the Orc4 Subunit. Molecular and Cellular Biology 21:23, pages 8095-8103.
Read now

Articles from other publishers (42)

Yixin Hu & Bruce Stillman. (2023) Origins of DNA replication in eukaryotes. Molecular Cell 83:3, pages 352-372.
Crossref
Logan Richards, Christopher L. Lord, Mary Lauren Benton, John A. Capra & Jared T. Nordman. (2022) Nucleoporins facilitate ORC loading onto chromatin. Cell Reports 41:6, pages 111590.
Crossref
Qiliang Ding, Matthew M. Edwards, Ning Wang, Xiang Zhu, Alexa N. Bracci, Michelle L. Hulke, Ya Hu, Yao Tong, Joyce Hsiao, Christine J. Charvet, Sulagna Ghosh, Robert E. Handsaker, Kevin Eggan, Florian T. Merkle, Jeannine Gerhardt, Dieter Egli, Andrew G. Clark & Amnon Koren. (2021) The genetic architecture of DNA replication timing in human pluripotent stem cells. Nature Communications 12:1.
Crossref
Branko Tomic & Jelena Kusic-Tisma. (2015) HsOrc4-dependent DNA remodeling of the ori-β DHFR replicator. Cellular and Molecular Biology Letters 20:4.
Crossref
Eve Shinbrot, Erin E. Henninger, Nils Weinhold, Kyle R. Covington, A. Yasemin Göksenin, Nikolaus Schultz, Hsu Chao, HarshaVardhan Doddapaneni, Donna M. Muzny, Richard A. Gibbs, Chris Sander, Zachary F. Pursell & David A. Wheeler. (2014) Exonuclease mutations in DNA polymerase epsilon reveal replication strand specific mutation patterns and human origins of replication. Genome Research 24:11, pages 1740-1750.
Crossref
Owen K. Smith & Mirit I. Aladjem. (2014) Chromatin Structure and Replication Origins: Determinants of Chromosome Replication and Nuclear Organization. Journal of Molecular Biology 426:20, pages 3330-3341.
Crossref
Rituparna Mukhopadhyay, Julien Lajugie, Nicolas Fourel, Ari Selzer, Michael Schizas, Boris Bartholdy, Jessica Mar, Chii Mei Lin, Melvenia M. Martin, Michael Ryan, Mirit I. Aladjem & Eric E. Bouhassira. (2014) Allele-Specific Genome-wide Profiling in Human Primary Erythroblasts Reveal Replication Program Organization. PLoS Genetics 10:5, pages e1004319.
Crossref
Naoya Okada & Noriaki Shimizu. (2013) Dissection of the Beta-Globin Replication-Initiation Region Reveals Specific Requirements for Replicator Elements during Gene Amplification. PLoS ONE 8:10, pages e77350.
Crossref
Xiaomi Chen, Guoqi Liu & Michael Leffak. (2013) Activation of a human chromosomal replication origin by protein tethering. Nucleic Acids Research 41:13, pages 6460-6474.
Crossref
Elisabeth Ott, Paolo Norio, Marion Ritzi, Carl Schildkraut & Aloys Schepers. (2011) The Dyad Symmetry Element of Epstein-Barr Virus Is a Dominant but Dispensable Replication Origin. PLoS ONE 6:5, pages e18609.
Crossref
Cristina Cotobal, Mónica Segurado & Francisco Antequera. (2010) Structural diversity and dynamics of genomic replication origins in Schizosaccharomyces pombe. The EMBO Journal 29:5, pages 934-942.
Crossref
Joyce L. Hamlin, Larry D. Mesner & Pieter A. Dijkwel. (2009) A winding road to origin discovery. Chromosome Research 18:1, pages 45-61.
Crossref
Takeshi Omasa, Yihua Cao, Joon Young Park, Yasuhiro Takagi, Shuichi Kimura, Hidenori Yano, Kohsuke Honda, Shuichi Asakawa, Nobuyoshi Shimizu & Hisao Ohtake. (2009) Bacterial artificial chromosome library for genome-wide analysis of Chinese hamster ovary cells. Biotechnology and Bioengineering 104:5, pages 986-994.
Crossref
Dragana Stefanovic, Jelena Kusic, Aleksandra Divac & Branko Tomic. (2008) Formation of Noncanonical DNA Structures Mediated by Human ORC4, a Protein Component of the Origin Recognition Complex. Biochemistry 47:33, pages 8760-8767.
Crossref
Yayoi Kinoshita, Edward M. Johnson, Ronald E. Gordon, Heather Negri-Bell, Mark T. Evans, Jennifer Coolbaugh, Yaseris Rosario-Peralta, Joseph Samet, Evelyn Slusser, Mark P. Birkenbach & Dianne C. Daniel. (2008) Colocalization of MCM8 and MCM7 with proteins involved in distinct aspects of DNA replication. Microscopy Research and Technique 71:4, pages 288-297.
Crossref
Noriaki Shimizu, Naoyuki Hanada, Kohichi Utani & Naoki Sekiguchi. (2007) Interconversion of intra- and extra-chromosomal sites of gene amplification by modulation of gene expression and DNA methylation. Journal of Cellular Biochemistry 102:2, pages 515-529.
Crossref
Mirit I. Aladjem. (2007) Replication in context: dynamic regulation of DNA replication patterns in metazoans. Nature Reviews Genetics 8:8, pages 588-600.
Crossref
Toshihiko Hashizume & Noriaki Shimizu. (2007) Dissection of mammalian replicators by a novel plasmid stability assay. Journal of Cellular Biochemistry 101:3, pages 552-565.
Crossref
Steven J. Gray, Guoqi Liu, Amy L. Altman, Lawrence E. Small & Ellen Fanning. (2007) Discrete functional elements required for initiation activity of the Chinese hamster dihydrofolate reductase origin beta at ectopic chromosomal sites. Experimental Cell Research 313:1, pages 109-120.
Crossref
Lixin Wang, Chii Mei Lin, Joseph O. Lopreiato & Mirit I. Aladjem. (2006) Cooperative sequence modules determine replication initiation sites at the human β-globin locus. Human Molecular Genetics 15:17, pages 2613-2622.
Crossref
Adriana Fiorini, Fabiana Souza de Gouveia, Maria Albertina Miranda de Soares, Ann Jacob Stocker, Ricardo Rodrigues Ciferri & Maria Aparecida Fernandez. (2006) DNA Bending in the Replication Zone of the C3 DNA Puff Amplicon of Rhynchosciara americana (Diptera: Sciaridae). Molecular Biology Reports 33:1, pages 71-82.
Crossref
Richard R. Sinden, Malgorzata J. Pytlos & Vladimir N. Potaman. 2006. Human Nucleotide Expansion Disorders. Human Nucleotide Expansion Disorders 3 53 .
Yesu Jeon, Stefan Bekiranov, Neerja Karnani, Philipp Kapranov, Srinka Ghosh, David MacAlpine, Charles Lee, Deog Su Hwang, Thomas R. Gingeras & Anindya Dutta. (2005) Temporal profile of replication of human chromosomes. Proceedings of the National Academy of Sciences 102:18, pages 6419-6424.
Crossref
Larry D. Mesner & Joyce L. Hamlin. (2005) Specific signals at the 3′ end of the DHFR gene define one boundary of the downstream origin of replication . Genes & Development 19:9, pages 1053-1066.
Crossref
John M. Casper, Michael G. Kemp, Maloy Ghosh, Gia M. Randall, Andrew Vaillant & Michael Leffak. (2005) The c-myc DNA-unwinding Element-binding Protein Modulates the Assembly of DNA Replication Complexes in Vitro. Journal of Biological Chemistry 280:13, pages 13071-13083.
Crossref
Jelena Kusic, Snezana Kojic, Aleksandra Divac & Dragana Stefanovic. (2005) Noncanonical DNA Elements in the Lamin B2 Origin of DNA Replication. Journal of Biological Chemistry 280:11, pages 9848-9854.
Crossref
Jindong Wang & Bill Sugden. (2005) Origins of bidirectional replication of Epstein-Barr virus: Models for understanding mammalian origins of DNA synthesis. Journal of Cellular Biochemistry 94:2, pages 247-256.
Crossref
John Tower. (2004) Developmental Gene Amplification and Origin Regulation. Annual Review of Genetics 38:1, pages 273-304.
Crossref
Stephanie M. Cohen, Seigo Hatada, Bruna P. Brylawski, Oliver Smithies, David G. Kaufman & Marila Cordeiro-Stone. (2004) Complementation of replication origin function in mouse embryonic stem cells by human DNA sequences. Genomics 84:3, pages 475-484.
Crossref
Andreas C. W. Jenke, Isa M. Stehle, Frank Herrmann, Tobias Eisenberger, Armin Baiker, Jürgen Bode, Frank O. Fackelmayer & Hans J. Lipps. (2004) Nuclear scaffold/matrix attached region modules linked to a transcription unit are sufficient for replication and maintenance of a mammalian episome. Proceedings of the National Academy of Sciences 101:31, pages 11322-11327.
Crossref
Mirit I Aladjem & Ellen Fanning. (2004) The replicon revisited: an old model learns new tricks in metazoan chromosomes. EMBO reports 5:7, pages 686-691.
Crossref
Lan Hu, Xin Xu & Manuel S Valenzuela. (2004) Initiation sites for human DNA replication at a putative ribulose-5-phosphate 3-epimerase gene. Biochemical and Biophysical Research Communications 320:3, pages 648-655.
Crossref
Alayne L Schroll & Nicholas H Heintz. (2004) Chemical footprinting of structural and functional elements of dhfr oriβ during the CHOC 400 cell cycle. Gene 332, pages 139-147.
Crossref
Lan Hu, Xin Xu & Manuel S Valenzuela. (2004) Identification of novel initiation sites for human DNA replication around ARSH1, a previously characterized yeast replicator. Biochemical and Biophysical Research Communications 313:4, pages 1058-1064.
Crossref
Sanjay Vashee, Christin Cvetic, Wenyan Lu, Pamela Simancek, Thomas J. Kelly & Johannes C. Walter. (2003) Sequence-independent DNA binding and replication initiation by the human origin recognition complex. Genes & Development 17:15, pages 1894-1908.
Crossref
Mauro Anglana, Françoise Apiou, Aaron Bensimon & Michelle Debatisse. (2003) Dynamics of DNA Replication in Mammalian Somatic Cells. Cell 114:3, pages 385-394.
Crossref
Melvin L DePamphilis. (2003) The ‘ORC cycle’: a novel pathway for regulating eukaryotic DNA replication. Gene 310, pages 1-15.
Crossref
Nawfal W. Istfan, Zhi-Yi Chen & Sybille Rex. (2002) Fish oil slows S phase progression and may cause upstream shift of DHFR replication origin ori-β in CHO cells. American Journal of Physiology-Cell Physiology 283:4, pages C1009-C1024.
Crossref
Wei-Hsin Sun, Thomas R. Coleman & Melvin L. DePamphilis. (2002) Cell cycle-dependent regulation of the association between origin recognition proteins and somatic cell chromatin. The EMBO Journal 21:6, pages 1437-1446.
Crossref
Heinz-Peter Nasheuer, Richard Smith, Christina Bauerschmidt, Frank Grosse & Klaus Weisshart. 2002. 41 94 .
David M. Gilbert. (2001) Making Sense of Eukaryotic DNA Replication Origins. Science 294:5540, pages 96-100.
Crossref
Marcel Méchali. (2001) DNA replication origins: from sequence specificity to epigenetics. Nature Reviews Genetics 2:8, pages 640-645.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.