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Molecular and Cellular Biology Volume 21, 2001 - Issue 4
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DNA Dynamics and Chromosome Structure

RNA Binding Domain of Telomerase Reverse Transcriptase

Cary K. LaiDivision of Biochemistry and Molecular Biology, Department of Molecular and Cell Biology, University of California, Berkeley, California94720-3204
,
James R. MitchellDivision of Biochemistry and Molecular Biology, Department of Molecular and Cell Biology, University of California, Berkeley, California94720-3204
&
Kathleen CollinsDivision of Biochemistry and Molecular Biology, Department of Molecular and Cell Biology, University of California, Berkeley, California94720-3204Correspondence[email protected]
Pages 990-1000 | Received 23 Oct 2000, Accepted 28 Nov 2000, Published online: 28 Mar 2023

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Joshua D. Podlevsky & Julian J.-L. Chen. (2016) Evolutionary perspectives of telomerase RNA structure and function. RNA Biology 13:8, pages 720-732.
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Franziska Bleichert & Susan J. Baserga. (2010) Ribonucleoprotein multimers and their functions. Critical Reviews in Biochemistry and Molecular Biology 45:5, pages 331-350.
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Andrea J. Berman, Anne R. Gooding & Thomas R. Cech. (2010) Tetrahymena Telomerase Protein p65 Induces Conformational Changes throughout Telomerase RNA (TER) and Rescues Telomerase Reverse Transcriptase and TER Assembly Mutants. Molecular and Cellular Biology 30:20, pages 4965-4976.
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William C. Drosopoulos & Vinayaka R. Prasad. (2010) The Telomerase-Specific T Motif Is a Restrictive Determinant of Repetitive Reverse Transcription by Human Telomerase. Molecular and Cellular Biology 30:2, pages 447-459.
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Timothy M. Errington, Dragony Fu, Judy M. Y. Wong & Kathleen Collins. (2008) Disease-Associated Human Telomerase RNA Variants Show Loss of Function for Telomere Synthesis without Dominant-Negative Interference. Molecular and Cellular Biology 28:20, pages 6510-6520.
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Sébastien Lepreux, Evelyne Doudnikoff, Incarnation Aubert, Paulette Bioulac-Sage, Bertrand Bloch & Marie-Laure Martin-Negrier. (2008) Cytoplasmic Expression of Human Telomerase Catalytic Protein (hTERT) in Neutrophils: An Immunoelectron Microscopy Study. Ultrastructural Pathology 32:5, pages 178-183.
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Elaine J. Middleman, Jinkuk Choi, Andrew S. Venteicher, Peggie Cheung & Steven E. Artandi. (2006) Regulation of Cellular Immortalization and Steady-State Levels of the Telomerase Reverse Transcriptase through Its Carboxy-Terminal Domain. Molecular and Cellular Biology 26:6, pages 2146-2159.
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Hong Ji, Margaret H. Platts, Latif M. Dharamsi & Katherine L. Friedman. (2005) Regulation of Telomere Length by an N-Terminal Region of the Yeast Telomerase Reverse Transcriptase. Molecular and Cellular Biology 25:20, pages 9103-9114.
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Doreen D. Cunningham & Kathleen Collins. (2005) Biological and Biochemical Functions of RNA in the Tetrahymena Telomerase Holoenzyme. Molecular and Cellular Biology 25:11, pages 4442-4454.
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Andrew S. Chappell & Victoria Lundblad. (2004) Structural Elements Required for Association of the Saccharomyces cerevisiae Telomerase RNA with the Est2 Reverse Transcriptase. Molecular and Cellular Biology 24:17, pages 7720-7736.
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Tara J. Moriarty, Delphine T. Marie-Egyptienne & Chantal Autexier. (2004) Functional Organization of Repeat Addition Processivity and DNA Synthesis Determinants in the Human Telomerase Multimer. Molecular and Cellular Biology 24:9, pages 3720-3733.
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Douglas X. Mason, Elizabeth Goneska & Carol W. Greider. (2003) Stem-Loop IV of Tetrahymena Telomerase RNA Stimulates Processivity in trans. Molecular and Cellular Biology 23:16, pages 5606-5613.
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Soma S. R. Banik, Chuanhai Guo, Allyson C. Smith, Seth S. Margolis, D. Ashley Richardson, Carlos A. Tirado & Christopher M. Counter. (2002) C-Terminal Regions of the Human Telomerase Catalytic Subunit Essential for In Vivo Enzyme Activity. Molecular and Cellular Biology 22:17, pages 6234-6246.
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Tara J. Moriarty, Sylvain Huard, Sophie Dupuis & Chantal Autexier. (2002) Functional Multimerization of Human Telomerase Requires an RNA Interaction Domain in the N Terminus of the Catalytic Subunit. Molecular and Cellular Biology 22:4, pages 1253-1265.
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Blaine N. Armbruster, Soma S. R. Banik, Chuanhai Guo, Allyson C. Smith & Christopher M. Counter. (2001) N-Terminal Domains of the Human Telomerase Catalytic Subunit Required for Enzyme Activity in Vivo. Molecular and Cellular Biology 21:22, pages 7775-7786.
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Fabrizio Fabbiano, Jessica Corsi, Elena Gurrieri, Caterina Trevisan, Michela Notarangelo & Vito G. D'Agostino. (2020) RNA packaging into extracellular vesicles: An orchestra of RNA‐binding proteins?. Journal of Extracellular Vesicles 10:2.
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Yang Liu, Pianping Fan, Yingying Yang, Changjun Xu, Yajuan Huang, Daizhu Li, Qing Qing, Chunyi Sun & Honglin Zhou. (2019) Human papillomavirus and human telomerase RNA component gene in cervical cancer progression. Scientific Reports 9:1.
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Linnea I. Jansson & Michael D. Stone. (2019) Single-Molecule Analysis of Reverse Transcriptase Enzymes. Cold Spring Harbor Perspectives in Biology 11:9, pages a032458.
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Jin H. Song, Hyun-Jin Kang, Libia A. Luevano, Vijay Gokhale, Kui Wu, Ritu Pandey, H.-H. Sherry Chow, Laurence H. Hurley & Andrew S. Kraft. (2019) Small-Molecule-Targeting Hairpin Loop of hTERT Promoter G-Quadruplex Induces Cancer Cell Death. Cell Chemical Biology 26:8, pages 1110-1121.e4.
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Wilnelly Hernandez-Sanchez, Wei Huang, Brian Plucinsky, Nelson Garcia-Vazquez, Nathaniel J. Robinson, William P. Schiemann, Anthony J. Berdis, Emmanuel Skordalakes & Derek J. Taylor. (2019) A non-natural nucleotide uses a specific pocket to selectively inhibit telomerase activity. PLOS Biology 17:4, pages e3000204.
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Xuehuo Zeng, Wilnelly Hernandez-Sanchez, Mengyuan Xu, Tawna L. Whited, Diane Baus, Junran Zhang, Anthony J. Berdis & Derek J. Taylor. (2018) Administration of a Nucleoside Analog Promotes Cancer Cell Death in a Telomerase-Dependent Manner. Cell Reports 23:10, pages 3031-3041.
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D. S. Nalobin, A. A. Galiakberova, S. I. Alipkina & A. I. Glukhov. (2018) Regulation of Telomerase Activity. Biology Bulletin Reviews 8:2, pages 142-154.
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Olga A Petrova, Alexey B Mantsyzov, Elena V Rodina, Sergey V Efimov, Claudia Hackenberg, Johanna Hakanpää, Vladimir V Klochkov, Andrej A Lebedev, Anastasia A Chugunova, Alexander N Malyavko, Timofei S Zatsepin, Alexey V Mishin, Maria I Zvereva, Victor S Lamzin, Olga A Dontsova & Vladimir I Polshakov. (2018) Structure and function of the N-terminal domain of the yeast telomerase reverse transcriptase. Nucleic Acids Research 46:3, pages 1525-1540.
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Alvina G. Lai, Natalia Pouchkina-Stantcheva, Alessia Di Donfrancesco, Gerda Kildisiute, Sounak Sahu & A. Aziz Aboobaker. (2017) The protein subunit of telomerase displays patterns of dynamic evolution and conservation across different metazoan taxa. BMC Evolutionary Biology 17:1.
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Theresa Vasko, Andrea Kaifie, Matthias Stope, Thomas Kraus & Patrick Ziegler. (2017) Telomeres and Telomerase in Hematopoietic Dysfunction: Prognostic Implications and Pharmacological Interventions. International Journal of Molecular Sciences 18:11, pages 2267.
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Akhil Varshney, Jyoti Bala, Baby Santosh, Ashima Bhaskar, Suresh Kumar & Pramod K. Yadava. (2016) Identification of an RNA aptamer binding hTERT-derived peptide and inhibiting telomerase activity in MCF7 cells. Molecular and Cellular Biochemistry 427:1-2, pages 157-167.
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Zhaowen Zhu, Huy Tran, M. Meleah Mathahs, Thomas O. Moninger & Warren N. Schmidt. (2017) HCV Induces Telomerase Reverse Transcriptase, Increases Its Catalytic Activity, and Promotes Caspase Degradation in Infected Human Hepatocytes. PLOS ONE 12:1, pages e0166853.
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Deanna MacNeil, Hélène Bensoussan & Chantal Autexier. (2016) Telomerase Regulation from Beginning to the End. Genes 7:9, pages 64.
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Yaqiang Wang, Joseph D. YesselmanQi ZhangMijeong Kang & Juli Feigon. (2016) Structural conservation in the template/pseudoknot domain of vertebrate telomerase RNA from teleost fish to human. Proceedings of the National Academy of Sciences 113:35.
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Vladimir I. Polshakov, Olga A. Petrova, Yulia Yu. Parfenova, Sergey V. Efimov, Vladimir V. Klochkov, Maria I. Zvereva & Olga A. Dontsova. (2015) NMR assignments of the N-terminal domain of Ogataea polymorpha telomerase reverse transcriptase. Biomolecular NMR Assignments 10:1, pages 183-187.
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W. Hernandez-Sanchez, M. Xu & D.J. Taylor. 2016. Genome Stability. Genome Stability 353 371 .
Linnea I Jansson, Ben M Akiyama, Alexandra Ooms, Cheng Lu, Seth M Rubin & Michael D Stone. (2015) Structural basis of template-boundary definition in Tetrahymena telomerase. Nature Structural & Molecular Biology 22:11, pages 883-888.
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Grzegorz Sarek, Paulina Marzec, Pol Margalef & Simon J Boulton. (2015) Molecular basis of telomere dysfunction in human genetic diseases. Nature Structural & Molecular Biology 22:11, pages 867-874.
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Jens C. Schmidt & Thomas R. Cech. (2015) Human telomerase: biogenesis, trafficking, recruitment, and activation. Genes & Development 29:11, pages 1095-1105.
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Elton J. R. Vasconcelos, Vinícius S. Nunes, Marcelo S. da Silva, Marcela Segatto, Peter J. Myler & Maria Isabel N. Cano. (2014) The Putative Leishmania Telomerase RNA (LeishTER) Undergoes Trans-Splicing and Contains a Conserved Template Sequence. PLoS ONE 9:11, pages e112061.
Crossref
Yoshinori Hayashi, Masaki Kajikawa, Takuma Matsumoto & Norihiro Okada. (2014) Mechanism by which a LINE protein recognizes its 3′ tail RNA. Nucleic Acids Research 42:16, pages 10605-10617.
Crossref
Varuni K. Jamburuthugoda & Thomas H. Eickbush. (2014) Identification of RNA binding motifs in the R2 retrotransposon-encoded reverse transcriptase. Nucleic Acids Research 42:13, pages 8405-8415.
Crossref
Petra Procházková Schrumpfová, Ivona Vychodilová, Martina Dvořáčková, Jana Majerská, Ladislav Dokládal, Šárka Schořová & Jiří Fajkus. (2014) Telomere repeat binding proteins are functional components of A rabidopsis telomeres and interact with telomerase . The Plant Journal 77:5, pages 770-781.
Crossref
Nak-Kyoon Kim, Qi Zhang & Juli Feigon. (2014) Structure and sequence elements of the CR4/5 domain of medaka telomerase RNA important for telomerase function. Nucleic Acids Research 42:5, pages 3395-3408.
Crossref
Ji Hoon Lee, Yang Sin Lee, Sun Ah Jeong, Prabhat Khadka, Jürgen Roth & In Kwon Chung. (2013) Catalytically active telomerase holoenzyme is assembled in the dense fibrillar component of the nucleolus during S phase. Histochemistry and Cell Biology 141:2, pages 137-152.
Crossref
Christopher G. Tomlinson, Scott B. Cohen & Tracy M. Bryan. 2014. Cancer Drug Design and Discovery. Cancer Drug Design and Discovery 491 527 .
Andrew F. Brown, Joshua D. Podlevsky & Julian J.-L. Chen. 2014. Nucleic Acid Polymerases. Nucleic Acid Polymerases 215 235 .
Michael Harkisheimer, Mark Mason, Elena Shuvaeva & Emmanuel Skordalakes. (2013) A Motif in the Vertebrate Telomerase N-Terminal Linker of TERT Contributes to RNA Binding and Telomerase Activity and Processivity. Structure 21:10, pages 1870-1878.
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Dagmar Zachová, Miloslava Fojtová, Martina Dvořáčková, Iva Mozgová, Inna Lermontova, Vratislav Peška, Ingo Schubert, Jiří Fajkus & Eva Sýkorová. (2013) Structure-function relationships during transgenic telomerase expression in Arabidopsis . Physiologia Plantarum 149:1, pages 114-126.
Crossref
Kyle R. Hukezalie & Judy M. Y. Wong. (2013) Structure-function relationship and biogenesis regulation of the human telomerase holoenzyme. FEBS Journal 280:14, pages 3194-3204.
Crossref
Benjamin M. Akiyama, Anastassia Gomez & Michael D. Stone. (2013) A Conserved Motif in Tetrahymena thermophila Telomerase Reverse Transcriptase Is Proximal to the RNA Template and Is Essential for Boundary Definition. Journal of Biological Chemistry 288:30, pages 22141-22149.
Crossref
Imke Listerman, Jie Sun, Francesca S. Gazzaniga, Jason L. Lukas & Elizabeth H. Blackburn. (2013) The Major Reverse Transcriptase–Incompetent Splice Variant of the Human Telomerase Protein Inhibits Telomerase Activity but Protects from Apoptosis. Cancer Research 73:9, pages 2817-2828.
Crossref
Jiansen Jiang, Edward J. Miracco, Kyungah Hong, Barbara Eckert, Henry Chan, Darian D. Cash, Bosun Min, Z. Hong Zhou, Kathleen Collins & Juli Feigon. (2013) The architecture of Tetrahymena telomerase holoenzyme. Nature 496:7444, pages 187-192.
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Raina A. Tamakawa, Helen B. Fleisig & Judy M. Y. Wong. 2013. Advances in DNA Repair in Cancer Therapy. Advances in DNA Repair in Cancer Therapy 229 279 .
Daud I. Cole, Jason D. Legassie, Laura N. Bonifacio, Vijay G. Sekaran, Feng Ding, Nikolay V. Dokholyan & Michael B. Jarstfer. (2012) New Models of Tetrahymena Telomerase RNA from Experimentally Derived Constraints and Modeling. Journal of the American Chemical Society 134:49, pages 20070-20080.
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Emily D. Egan & Kathleen Collins. (2012) Biogenesis of telomerase ribonucleoproteins. RNA 18:10, pages 1747-1759.
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Tracy T. Chow, Yong Zhao, Sabrina S. Mak, Jerry W. Shay & Woodring E. Wright. (2012) Early and late steps in telomere overhang processing in normal human cells: the position of the final RNA primer drives telomere shortening. Genes & Development 26:11, pages 1167-1178.
Crossref
Emmanuel Skordalakes & Neal F. Lue. 2012. Telomerases. Telomerases 53 78 .
Barbara Eckert & Kathleen Collins. (2012) Roles of Telomerase Reverse Transcriptase N-terminal Domain in Assembly and Activity of Tetrahymena Telomerase Holoenzyme. Journal of Biological Chemistry 287:16, pages 12805-12814.
Crossref
Joshua D. Podlevsky & Julian J.-L. Chen. (2012) It all comes together at the ends: Telomerase structure, function, and biogenesis. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 730:1-2, pages 3-11.
Crossref
Laetitia Trapp-Fragnet, Delphine Marie-Egyptienne, Johans Fakhoury, Denis Rasschaert & Chantal Autexier. (2012) The human telomerase catalytic subunit and viral telomerase RNA reconstitute a functional telomerase complex in a cell-free system, but not in human cells. Cellular and Molecular Biology Letters 17:4.
Crossref
Karen A. Lewis & Deborah S. Wuttke. (2012) Telomerase and Telomere-Associated Proteins: Structural Insights into Mechanism and Evolution. Structure 20:1, pages 28-39.
Crossref
Yanan Cai, Yongxing Ai, Quan Zhao, Jianhua Li, Guilian Yang, Pengtao Gong, Qiuyue Wang, Honglie Hou, Guocai Zhang, Lingdan Li, Ju Yang, He Li, Jun Zheng, Shuhong Li & Xichen Zhang. (2011) Cloning and characterization of telomerase reverse transcriptase gene in Trichinella spiralis. Parasitology Research 110:1, pages 411-417.
Crossref
Craig Nicholls, He Li, Jian-Qiu Wang & Jun-Ping Liu. (2011) Molecular regulation of telomerase activity in aging. Protein & Cell 2:9, pages 726-738.
Crossref
Aaron R. Robart & Kathleen Collins. (2011) Human Telomerase Domain Interactions Capture DNA for TEN Domain-Dependent Processive Elongation. Molecular Cell 42:3, pages 308-318.
Crossref
Mark Mason, Anthony Schuller & Emmanuel Skordalakes. (2011) Telomerase structure function. Current Opinion in Structural Biology 21:1, pages 92-100.
Crossref
M. I. Zvereva, D. M. Shcherbakova & O. A. Dontsova. (2011) Telomerase: Structure, functions, and activity regulation. Biochemistry (Moscow) 75:13, pages 1563-1583.
Crossref
H. D. M. Wyatt, S. C. West & T. L. Beattie. (2010) InTERTpreting telomerase structure and function. Nucleic Acids Research 38:17, pages 5609-5622.
Crossref
Vijay G. Sekaran, Joana Soares & Michael B. Jarstfer. (2010) Structures of telomerase subunits provide functional insights. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1804:5, pages 1190-1201.
Crossref
Meghan Mitchell, Andrew Gillis, Mizuko Futahashi, Haruhiko Fujiwara & Emmanuel Skordalakes. (2010) Structural basis for telomerase catalytic subunit TERT binding to RNA template and telomeric DNA. Nature Structural & Molecular Biology 17:4, pages 513-518.
Crossref
Aaron R. Robart, Catherine M. O'Connor & Kathleen Collins. (2010) Ciliate telomerase RNA loop IV nucleotides promote hierarchical RNP assembly and holoenzyme stability. RNA 16:3, pages 563-571.
Crossref
Laura Gardano & Lea Harrington. 2010. Cellular Senescence and Tumor Suppression. Cellular Senescence and Tumor Suppression 3 43 .
Stephen Kearsey, Judith L Campbell, Genevieve Almouzni, Joanna Poulton, Takehiro Yasukawa, Steve Bell, Ron Laskey, Tom Kunkel, James Chong, Xinquan Ge, Julian Blow, Christian Speck, Ginger Jiang, Ellen Fanning, Helle D Ulrich, Christian Haering, James Chong, Ji-Liang Li, Tracy Bryan & Alison WaltersTracy M. Bryan. 2009. Molecular Themes in DNA Replication. Molecular Themes in DNA Replication 217 268 .
Emmanuel Skordalakes. (2009) Telomerase structure paves the way for new cancer therapies. Future Oncology 5:2, pages 163-167.
Crossref
Trystan B. Wells, Guanglei Zhang, Zenon Harley & Homayoun Vaziri. (2009) Genetic Hypervariability in Two Distinct Deuterostome Telomerase Reverse Transcriptase Genes and their Early Embryonic Functions. Molecular Biology of the Cell 20:1, pages 464-480.
Crossref
Kathleen Collins. 2009. Non-Protein Coding RNAs. Non-Protein Coding RNAs 285 301 .
Shintaro Imamura, Junzo Uchiyama, Eriko Koshimizu, Jun-ichi Hanai, Christina Raftopoulou, Ryan D. Murphey, Peter E. Bayliss, Yoichi Imai, Caroline Erter Burns, Kenkichi Masutomi, Sarantis Gagos, Leonard I. Zon, Thomas M. Roberts & Shuji Kishi. (2008) A Non-Canonical Function of Zebrafish Telomerase Reverse Transcriptase Is Required for Developmental Hematopoiesis. PLoS ONE 3:10, pages e3364.
Crossref
Andrew J. Gillis, Anthony P. Schuller & Emmanuel Skordalakes. (2008) Structure of the Tribolium castaneum telomerase catalytic subunit TERT. Nature 455:7213, pages 633-637.
Crossref
Sharon N. Finger & Tracy M. Bryan. (2008) Multiple DNA-binding sites in Tetrahymena telomerase. Nucleic Acids Research 36:4, pages 1260-1272.
Crossref
Anna Marrone, Amanda Walne, Hannah Tamary, Yuka Masunari, Michael Kirwan, Richard Beswick, Tom Vulliamy & Inderjeet Dokal. (2007) Telomerase reverse-transcriptase homozygous mutations in autosomal recessive dyskeratosis congenita and Hoyeraal-Hreidarsson syndrome. Blood 110:13, pages 4198-4205.
Crossref
Susan Rouda & Emmanuel Skordalakes. (2007) Structure of the RNA-Binding Domain of Telomerase: Implications for RNA Recognition and Binding. Structure 15:11, pages 1403-1412.
Crossref
Neal F. Lue & Zhaohui Li. (2007) Modeling and structure function analysis of the putative anchor site of yeast telomerase. Nucleic Acids Research 35:15, pages 5213-5222.
Crossref
Erez Romi, Nava Baran, Marina Gantman, Michael Shmoish, Bosun Min, Kathleen Collins & Haim Manor. (2007) High-resolution physical and functional mapping of the template adjacent DNA binding site in catalytically active telomerase. Proceedings of the National Academy of Sciences 104:21, pages 8791-8796.
Crossref
Giuseppe Pelosi, Barbara Del Curto, Maurizio Trubia, Andrew G. Nicholson, Michela Manzotti, Giulia Veronesi, Lorenzo Spaggiari, Patrick Maisonneuve, Felice Pasini, Alberto Terzi, Antonio Iannucci & Giuseppe Viale. (2007) 3q26 Amplification and Polysomy of Chromosome 3 in Squamous Cell Lesions of the Lung: A Fluorescence In situ Hybridization Study . Clinical Cancer Research 13:7, pages 1995-2004.
Crossref
Zhong-Tao XinAdam D. BeauchampRodrigo T. CaladoJennifer W. BradfordJoshua A. RegalAarthi ShenoyYuying LiangPeter M. Lansdorp, Neal S. YoungHinh Ly. (2006) Functional characterization of natural telomerase mutations found in patients with hematologic disorders. Blood 109:2, pages 524-532.
Crossref
Jun-Ping Liu, Lucy Cassar, Alex Pinto & He Li. (2006) Mechanisms of cell immortalization mediated by EB viral activation of telomerase in nasopharyngeal carcinoma. Cell Research 16:10, pages 809-817.
Crossref
Michael Terribilini, Jae-Hyung Lee, Changhui Yan, Robert L. Jernigan, Vasant Honavar & Drena Dobbs. (2006) Prediction of RNA binding sites in proteins from amino acid sequence. RNA 12:8, pages 1450-1462.
Crossref
Rebecca J. Richards, Haihong Wu, Lukas Trantirek, Catherine M. O'Connor, Kathleen Collins & Juli Feigon. (2006) Structural study of elements of Tetrahymena telomerase RNA stem–loop IV domain important for function . RNA 12:8, pages 1475-1485.
Crossref
Yu Chen, Jessica Fender, Jason D Legassie, Michael B Jarstfer, Tracy M Bryan & Gabriele Varani. (2006) Structure of stem-loop IV of Tetrahymena telomerase RNA. The EMBO Journal 25:13, pages 3156-3166.
Crossref
Ying-Li Wu, Charles Dudognon, Eric Nguyen, Josette Hillion, Frédéric Pendino, Ilona Tarkanyi, Janos Aradi, Michel Lanotte, Jian-Hua Tong, Guo-Qiang Chen & Evelyne Ségal-Bendirdjian. (2006) Immunodetection of human telomerase reverse-transcriptase (hTERT) re-appraised: nucleolin and telomerase cross paths. Journal of Cell Science 119:13, pages 2797-2806.
Crossref
Kathleen Collins. (2006) The biogenesis and regulation of telomerase holoenzymes. Nature Reviews Molecular Cell Biology 7:7, pages 484-494.
Crossref
Chantal AutexierNeal F. Lue. (2006) The Structure and Function of Telomerase Reverse Transcriptase. Annual Review of Biochemistry 75:1, pages 493-517.
Crossref
Miriam A. Giardini, Cristina B. B. Lira, Fábio F. Conte, Luciana R. Camillo, Jair L. de Siqueira Neto, Carlos H. I. Ramos & Maria Isabel N. Cano. (2006) The putative telomerase reverse transcriptase component of Leishmania amazonensis: gene cloning and characterization. Parasitology Research 98:5, pages 447-454.
Crossref
Steven A Jacobs, Elaine R Podell & Thomas R Cech. (2006) Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase. Nature Structural & Molecular Biology 13:3, pages 218-225.
Crossref
Bettina Meier, Iuval Clejan, Yan Liu, Mia Lowden, Anton Gartner, Jonathan Hodgkin & Shawn Ahmed. (2006) trt-1 Is the Caenorhabditis elegans Catalytic Subunit of Telomerase. PLoS Genetics 2:2, pages e18.
Crossref
TARA J. MORIARTY, DELPHINE T. MARIE-EGYPTIENNE & CHANTAL AUTEXIER. (2005) Regulation of 5′ template usage and incorporation of noncognate nucleotides by human telomerase. RNA 11:9, pages 1448-1460.
Crossref
Tara J. Moriarty, Ryan J. Ward, Michael A.S. Taboski & Chantal Autexier. (2005) An Anchor Site–Type Defect in Human Telomerase That Disrupts Telomere Length Maintenance and Cellular Immortalization. Molecular Biology of the Cell 16:7, pages 3152-3161.
Crossref
Neal F. Lue. (2005) A Physical and Functional Constituent of Telomerase Anchor Site. Journal of Biological Chemistry 280:28, pages 26586-26591.
Crossref
Wai Ho Yap, Elizabeth Yeoh, Sydney Brenner & Byrappa Venkatesh. (2005) Cloning and expression of the reverse transcriptase component of pufferfish (Fugu rubripes) telomerase. Gene 353:2, pages 207-217.
Crossref
THOMAS C. LEEPER & GABRIELE VARANI. (2005) The structure of an enzyme-activating fragment of human telomerase RNA. RNA 11:4, pages 394-403.
Crossref
Catherine M. O'Connor, Cary K. Lai & Kathleen Collins. (2005) Two Purified Domains of Telomerase Reverse Transcriptase Reconstitute Sequence-specific Interactions with RNA. Journal of Biological Chemistry 280:17, pages 17533-17539.
Crossref
Ramadevi Prathapam, Keren L Witkin, Catherine M O'Connor & Kathleen Collins. (2005) A telomerase holoenzyme protein enhances telomerase RNA assembly with telomerase reverse transcriptase. Nature Structural & Molecular Biology 12:3, pages 252-257.
Crossref
Ying Yang. (2005) Combined effects of Cantide and chemotherapeutic drugs on inhibition of tumor cells’ growth in vitro and in vivo . World Journal of Gastroenterology 11:16, pages 2491.
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Danny Tze-Ming Leung, Chun-Hung Ma, Haitao Niu, Choong-Tsek Liew, Janet Tsui-Ying Tang & Pak-Leong Lim. (2004) Nuclear telomerase is less accessible to antibody probing than known nuclear antigens: retrieval with new immunostaining buffer. Histochemistry and Cell Biology 123:1, pages 105-112.
Crossref
Soma S.R. Banik & Christopher M. Counter. (2004) Characterization of Interactions between PinX1 and Human Telomerase Subunits hTERT and hTR. Journal of Biological Chemistry 279:50, pages 51745-51748.
Crossref
Keiko Oguchi, Katsunori Tamura & Hideo Takahashi. (2004) Characterization of Oryza sativa telomerase reverse transcriptase and possible role of its phosphorylation in the control of telomerase activity. Gene 342:1, pages 57-66.
Crossref
Mary E. Delany & Laura M. Daniels. (2004) The chicken telomerase reverse transcriptase (chTERT): molecular and cytogenetic characterization with a comparative analysis. Gene 339, pages 61-69.
Crossref
Neal F. Lue. (2004) Adding to the ends: what makes telomerase processive and how important is it?. BioEssays 26:9, pages 955-962.
Crossref
STEFAN AIGNER & THOMAS R. CECH. (2004) The Euplotes telomerase subunit p43 stimulates enzymatic activity and processivity in vitro . RNA 10:7, pages 1108-1118.
Crossref
Lubna Nasir, Elizabeth Gault, Sarah Campbell, Mallika Veeramalai, David Gilbert, Robert McFarlane, Alison Munro & David J Argyle. (2004) Isolation and expression of the reverse transcriptase component of the Canis familiaris telomerase ribonucleoprotein (dogTERT). Gene 336:1, pages 105-113.
Crossref
Jiunn-Liang Chen & Carol W. Greider. (2004) Telomerase RNA structure and function: implications for dyskeratosis congenita. Trends in Biochemical Sciences 29:4, pages 183-192.
Crossref
Jue Lin & Elizabeth H. Blackburn. (2004) Nucleolar protein PinX1p regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNA. Genes & Development 18:4, pages 387-396.
Crossref
Ilaria Sciamanna, Laura Barberi, Alberto Martire, Carmine Pittoggi, Rosanna Beraldi, Roberto Giordano, Anna Rosa Magnano, Clague Hogdson & Corrado Spadafora. (2003) Sperm endogenous reverse transcriptase as mediator of new genetic information. Biochemical and Biophysical Research Communications 312:4, pages 1039-1046.
Crossref
Jiunn-Liang Chen & Carol W. Greider. (2003) Template boundary definition in mammalian telomerase. Genes & Development 17:22, pages 2747-2752.
Crossref
Cary K. Lai, Michael C. Miller & Kathleen Collins. (2003) Roles for RNA in Telomerase Nucleotide and Repeat Addition Processivity. Molecular Cell 11:6, pages 1673-1683.
Crossref
Lea Harrington. (2003) Biochemical aspects of telomerase function. Cancer Letters 194:2, pages 139-154.
Crossref
Zemfira Karamysheva, Libin Wang, Timothy Shrode, Janna Bednenko, Leigh Anne Hurley & Dorothy E. Shippen. (2003) Developmentally Programmed Gene Elimination in Euplotes crassus Facilitates a Switch in the Telomerase Catalytic Subunit. Cell 113:5, pages 565-576.
Crossref
Dimitry Bosoy, Yun Peng, I. Saira Mian & Neal F. Lue. (2003) Conserved N-terminal Motifs of Telomerase Reverse Transcriptase Required for Ribonucleoprotein Assembly in Vivo. Journal of Biological Chemistry 278:6, pages 3882-3890.
Crossref
JunJian Huang, Yun Xiu Bai, Su Wen Han, Samuel S.M Ng, Da Dao Jing, Benjamin C.Y Wong, Cui-fen Huang, Hsiang-fu Kung & Marie C.M Lin. (2003) A human TERT C-terminal polypeptide sensitizes HeLa cells to H2O2-induced senescence without affecting telomerase enzymatic activity. Biochemical and Biophysical Research Communications 301:3, pages 627-632.
Crossref
Katherine L. FriedmanJeremy J. Heit, David M. Long & Thomas R. Cech. (2003) N-terminal Domain of Yeast Telomerase Reverse Transcriptase: Recruitment of Est3p to the Telomerase Complex. Molecular Biology of the Cell 14:1, pages 1-13.
Crossref
Colleen Kelleher, M.Teresa Teixeira, Klaus Förstemann & Joachim Lingner. (2002) Telomerase: biochemical considerations for enzyme and substrate. Trends in Biochemical Sciences 27:11, pages 572-579.
Crossref
Shabbir Hossain, Sunitha Singh & Neal F. Lue. (2002) Functional Analysis of the C-terminal Extension of Telomerase Reverse Transcriptase. Journal of Biological Chemistry 277:39, pages 36174-36180.
Crossref
Katherine T. Etheridge, Soma S.R. Banik, Blaine N. Armbruster, Yusheng Zhu, Rebecca M. Terns, Michael P. Terns & Christopher M. Counter. (2002) The Nucleolar Localization Domain of the Catalytic Subunit of Human Telomerase. Journal of Biological Chemistry 277:27, pages 24764-24770.
Crossref
Amanda J. Ye & Daniel P. Romero. (2002) A unique pause pattern during telomere addition by the error-prone telomerase from the ciliate Paramecium tetraurelia. Gene 294:1-2, pages 205-213.
Crossref
Yinhua Yang, Yaohui Chen, Chunyu Zhang, Hai Huang & Sherman M. Weissman. (2002) Nucleolar Localization of hTERT Protein Is Associated with Telomerase Function. Experimental Cell Research 277:2, pages 201-209.
Crossref
Michael C. Miller & Kathleen Collins. (2002) Telomerase recognizes its template by using an adjacent RNA motif. Proceedings of the National Academy of Sciences 99:10, pages 6585-6590.
Crossref
Ravindra N. Singh, Roland J. Saldanha, Lisa M. D'Souza & Alan M. Lambowitz. (2002) Binding of a Group II Intron-encoded Reverse Transcriptase/Maturase to Its High Affinity Intron RNA Binding Site Involves Sequence-specific Recognition and Autoregulates Translation. Journal of Molecular Biology 318:2, pages 287-303.
Crossref
Cary K. Lai, Michael C. Miller & Kathleen Collins. (2002) Template boundary definition in Tetrahymena telomerase . Genes & Development 16:4, pages 415-420.
Crossref
Kathleen Collins & James R Mitchell. (2002) Telomerase in the human organism. Oncogene 21:4, pages 564-579.
Crossref
Irina R. Arkhipova & Hilary G. Morrison. (2001) Three retrotransposon families in the genome of Giardia lamblia : Two telomeric, one dead . Proceedings of the National Academy of Sciences 98:25, pages 14497-14502.
Crossref
Dimitry Bosoy & Neal F. Lue. (2001) Functional Analysis of Conserved Residues in the Putative “Finger” Domain of Telomerase Reverse Transcriptase. Journal of Biological Chemistry 276:49, pages 46305-46312.
Crossref
Masashi Kuramoto, Keita Ohsumi, Takeo Kishimoto & Fuyuki Ishikawa. (2001) Identification and analyses of the Xenopus TERT gene that encodes the catalytic subunit of telomerase. Gene 277:1-2, pages 101-110.
Crossref
. (2001) Anti-Aging Medicine LiteratureWatch. Journal of Anti-Aging Medicine 4:2, pages 157-179.
Crossref

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