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Molecular and Cellular Biology Volume 21, 2001 - Issue 7
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Cell Growth and Development

Association of Insulin Receptor Substrate 1 (IRS-1) Y895 with Grb-2 Mediates the Insulin Signaling Involved in IRS-1-Deficient Brown Adipocyte Mitogenesis

Angela M. Valverde1 Departamento de Bioquı́mica y Biologı́a Molecular, Centro Mixto CSIC/UCM, Facultad de Farmacia
,
Cecilia Mur1 Departamento de Bioquı́mica y Biologı́a Molecular, Centro Mixto CSIC/UCM, Facultad de Farmacia
,
Sebastián Pons2 Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts
,
Alberto M. Alvarez3 Centro de Citometrı́a de Flujo y Microscopı́a Confocal, Universidad Complutense, 28040Madrid, Spain
,
Morris F. White2 Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts
,
C. Ronald Kahn2 Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts
&
Manuel Benito1 Departamento de Bioquı́mica y Biologı́a Molecular, Centro Mixto CSIC/UCM, Facultad de FarmaciaCorrespondence[email protected]
 show all
Pages 2269-2280 | Received 13 Apr 2000, Accepted 03 Jan 2001, Published online: 27 Mar 2023

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Rocio Vila-Bedmar & Sonia Fernández-Veledo. (2011) A new era for brown adipose tissue: New insights into brown adipocyte function and differentiation. Archives of Physiology and Biochemistry 117:3, pages 195-208.
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Articles from other publishers (26)

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Katie Vines, Rongzi Li, Thangiah Geetha, Tom L. Broderick, Chad C. Carroll & Jeganathan Ramesh Babu. (2019) Nerve growth factor receptor TrkA signaling in streptozotocin-induced type 1 diabetes rat brain. Biochemical and Biophysical Research Communications 514:4, pages 1285-1289.
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Thangiah Geetha, Shraddha D. Rege, Salome E. Mathews, Susan O. Meakin, Morris F. White & Jeganathan Ramesh Babu. (2013) Nerve Growth Factor Receptor TrkA, a New Receptor in Insulin Signaling Pathway in PC12 Cells. Journal of Biological Chemistry 288:33, pages 23807-23813.
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Rosalyne L. Westley & Felicity E. B. May. (2013) A Twenty-First Century Cancer Epidemic Caused by Obesity: The Involvement of Insulin, Diabetes, and Insulin-Like Growth Factors. International Journal of Endocrinology 2013, pages 1-37.
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Krzysztof Reiss, Luis Del Valle, Adam Lassak & Joanna Trojanek. (2012) Nuclear IRS-1 and cancer. Journal of Cellular Physiology 227:8, pages 2992-3000.
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Alex F. Bokov, Neha Garg, Yuji Ikeno, Sachin Thakur, Nicolas Musi, Ralph A. DeFronzo, Ning Zhang, Rebecca C. Erickson, Jon Gelfond, Gene B. Hubbard, Martin L. Adamo & Arlan Richardson. (2011) Does Reduced IGF-1R Signaling in Igf1r+/− Mice Alter Aging?. PLoS ONE 6:11, pages e26891.
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Louise FritscheSabine S. NeukammRainer LehmannElisabeth Kremmer, Anita M. HennigeAndrea Hunder-Gugel, Martin Schenk, Hans-Ulrich HäringErwin D. SchleicherCora Weigert. (2011) Insulin-induced serine phosphorylation of IRS-2 via ERK1/2 and mTOR: studies on the function of Ser 675 and Ser 907 . American Journal of Physiology-Endocrinology and Metabolism 300:5, pages E824-E836.
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Yashwanth Radhakrishnan, Walker H. BusbyJr.Jr., Xinchun Shen, Laura A. Maile & David R. Clemmons. (2010) Insulin-like Growth Factor-I-stimulated Insulin Receptor Substrate-1 Negatively Regulates Src Homology 2 Domain-containing Protein-tyrosine Phosphatase Substrate-1 Function in Vascular Smooth Muscle Cells. Journal of Biological Chemistry 285:21, pages 15682-15695.
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C. Ronald Kahn & Ryo Suzuki. 2010. Diabetes, Insulin and Alzheimer's Disease. Diabetes, Insulin and Alzheimer's Disease 1 20 .
Xiangdong Wang, Ning Yang, Luqin Deng, Xin Li, Jing Jiang, Yujun Gan & Stuart J. Frank. (2009) Interruption of Growth Hormone Signaling via SHC and ERK in 3T3-F442A Preadipocytes upon Knockdown of Insulin Receptor Substrate-1. Molecular Endocrinology 23:4, pages 486-496.
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Shailly Varma & Ramji L. Khandelwal. (2008) Overexpression of Akt1 upregulates glycogen synthase activity and phosphorylation of mTOR in IRS-1 knockdown HepG2 cells. Journal of Cellular Biochemistry 103:5, pages 1424-1437.
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S. Hoyer & L. Frölich. 2007. Handbook of Neurochemistry and Molecular Neurobiology. Handbook of Neurochemistry and Molecular Neurobiology 189 232 .
Suzanne Gaudet, Kevin A. Janes, John G. Albeck, Emily A. Pace, Douglas A. Lauffenburger & Peter K. Sorger. (2005) A Compendium of Signals and Responses Triggered by Prodeath and Prosurvival Cytokines. Molecular & Cellular Proteomics 4:10, pages 1569-1590.
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A. M. Valverde, M. Benito & M. Lorenzo. (2005) The brown adipose cell: a model for understanding the molecular mechanisms of insulin resistance. Acta Physiologica Scandinavica 183:1, pages 59-73.
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Margarita Lorenzo, Ángela M. Valverde & Manuel Benito. 2005. The Metabolic Syndrome at the Beginning of the XXI Century. The Metabolic Syndrome at the Beginning of the XXI Century 43 65 .
Angela M. Valverde, Cecilia Mur, Michael Brownlee & Manuel Benito. (2004) Susceptibility to Apoptosis in Insulin-like Growth Factor-I Receptor-deficient Brown Adipocytes. Molecular Biology of the Cell 15:11, pages 5101-5117.
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BARBARA CANNON & JAN NEDERGAARD. (2004) Brown Adipose Tissue: Function and Physiological Significance. Physiological Reviews 84:1, pages 277-359.
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Mónica Arribas, Angela M. Valverde & Manuel Benito. (2003) Role of IRS-3 in the Insulin Signaling of IRS-1-deficient Brown Adipocytes. Journal of Biological Chemistry 278:46, pages 45189-45199.
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Angela M. Valverde, Mónica Arribas, Cecilia Mur, Paloma Navarro, Sebastián Pons, Anne-Marie Cassard-Doulcier, C. Ronald Kahn & Manuel Benito. (2003) Insulin-induced Up-regulated Uncoupling Protein-1 Expression Is Mediated by Insulin Receptor Substrate 1 through the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway in Fetal Brown Adipocytes. Journal of Biological Chemistry 278:12, pages 10221-10231.
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Mónica Arribas, Angela M Valverde, Deborah Burks, Johannes Klein, Robert V Farese, Morris F White & Manuel Benito. (2003) Essential role of protein kinase Cζ in the impairment of insulin-induced glucose transport in IRS-2-deficient brown adipocytes. FEBS Letters 536:1-3, pages 161-166.
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Johannes Klein, Mathias Fasshauer, Harald H. Klein, Manuel Benito & C. Ronald Kahn. (2002) Novel adipocyte lines from brown fat: A model system for the study of differentiation, energy metabolism, and insulin action. BioEssays 24:4, pages 382-388.
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Cecilia Mur, Angela M. Valverde, C. Ronald Kahn & Manuel Benito. (2002) Increased Insulin Sensitivity in IGF-I Receptor–Deficient Brown Adipocytes. Diabetes 51:3, pages 743-754.
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Almudena Porras & Manuel Benito. 2002. Sensing, Signaling and Cell Adaptation. Sensing, Signaling and Cell Adaptation 269 282 .

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