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Cell Growth and Development

Regulation of Ras Signaling Specificity by Protein Kinase C

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Pages 2650-2658 | Received 07 Jun 2000, Accepted 30 Jan 2001, Published online: 28 Mar 2023

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Larry A. Feig & Rachel J. Buchsbaum. (2002) Cell Signaling: Life or Death Decisions of Ras Proteins. Current Biology 12:7, pages R259-R261.
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