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Gene Expression

The Peptide Near the C Terminus Regulates Receptor CAR Nuclear Translocation Induced by Xenochemicals in Mouse Liver

Igor ZelkoPharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina27709
,
Tatsuya SueyoshiPharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina27709
,
Takeshi KawamotoPharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina27709
,
Rick MoorePharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina27709
&
Masahiko NegishiPharmacogenetics Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina27709Correspondence[email protected]
Pages 2838-2846 | Received 20 Oct 2000, Accepted 16 Jan 2001, Published online: 28 Mar 2023

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Ryota Shizu, Makoto Osabe, Lalith Perera, Rick Moore, Tatsuya Sueyoshi & Masahiko Negishi. (2017) Phosphorylated Nuclear Receptor CAR Forms a Homodimer To Repress Its Constitutive Activity for Ligand Activation. Molecular and Cellular Biology 37:10.
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Marija Pinne & Judy L Raucy. (2014) Advantages of cell-based high-volume screening assays to assess nuclear receptor activation during drug discovery. Expert Opinion on Drug Discovery 9:6, pages 669-686.
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Masashi Honma, Masanari Kozawa & Hiroshi Suzuki. (2010) Methods for the quantitative evaluation and prediction of CYP enzyme induction using human in vitro systems. Expert Opinion on Drug Discovery 5:5, pages 491-511.
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Haishan Li & Hongbing Wang. (2010) Activation of xenobiotic receptors: driving into the nucleus. Expert Opinion on Drug Metabolism & Toxicology 6:4, pages 409-426.
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M. A. Gray, J. N. Peacock & E. J. Squires. (2009) Characterization of the porcine constitutive androstane receptor (CAR) and its splice variants. Xenobiotica 39:12, pages 915-930.
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Lesley A. Stanley, Brian C. Horsburgh, Jillian Ross, Nico Scheer & C. Roland Wolf. (2006) PXR and CAR: Nuclear Receptors which Play a Pivotal Role in Drug Disposition and Chemical Toxicity. Drug Metabolism Reviews 38:3, pages 515-597.
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J.-M. Pascussi, S. Gerbal-Chaloin, L. Drocourt, E. Assénat, D. Larrey, L. Pichard-Garcia, M.-J. Vilarem & P. Maurel. (2004) Cross-talk between xenobiotic detoxication and other signalling pathways: clinical and toxicological consequences. Xenobiotica 34:7, pages 633-664.
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Matthew R. Yudt, Christine M. Jewell, Rachelle J. Bienstock & John A. Cidlowski. (2003) Molecular Origins for the Dominant Negative Function of Human Glucocorticoid Receptor Beta. Molecular and Cellular Biology 23:12, pages 4319-4330.
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Marcel J. M. Schaaf & John A. Cidlowski. (2003) Molecular Determinants of Glucocorticoid Receptor Mobility in Living Cells: the Importance of Ligand Affinity. Molecular and Cellular Biology 23:6, pages 1922-1934.
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Jean Marc Pascussi, Zdenek Dvorák, Sabine Gerbal-Chaloin, Eric Assenat, Patrick Maurel & Marie José Vilarem. (2003) Pathophysiological Factors Affecting CAR Gene Expression. Drug Metabolism Reviews 35:4, pages 255-268.
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G. G. Gibson, N. J. Plant, K. E. Swales, A. Ayrton & W. El-Sankary. (2002) Receptor-dependent transcriptional activation of cytochrome P4503A genes: induction mechanisms, species differences and interindividual variation in man. Xenobiotica 32:3, pages 165-206.
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