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Transcriptional Regulation

A Structural Model of the Constitutive Androstane Receptor Defines Novel Interactions That Mediate Ligand-Independent Activity

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Pages 5270-5280 | Received 01 Feb 2002, Accepted 25 Apr 2002, Published online: 27 Mar 2023

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Cameron D. Buchman, Sergio C. Chai & Taosheng Chen. (2018) A current structural perspective on PXR and CAR in drug metabolism. Expert Opinion on Drug Metabolism & Toxicology 14:6, pages 635-647.
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M. A. Gray, J. N. Peacock & E. J. Squires. (2009) Characterization of the porcine constitutive androstane receptor (CAR) and its splice variants. Xenobiotica 39:12, pages 915-930.
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Lesley A. Stanley, Brian C. Horsburgh, Jillian Ross, Nico Scheer & C. Roland Wolf. (2006) PXR and CAR: Nuclear Receptors which Play a Pivotal Role in Drug Disposition and Chemical Toxicity. Drug Metabolism Reviews 38:3, pages 515-597.
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Paavo Honkakoski, Tatsuya Sueyoshi & Masahiko Negishi. (2003) Drug-activated nuclear receptors CAR and PXR. Annals of Medicine 35:3, pages 172-182.
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Bill Pham, Ziju Cheng, Daniel Lopez, Richard J. Lindsay, David Foutch, Rily T. Majors & Tongye Shen. (2022) Statistical Analysis of Protein-Ligand Interaction Patterns in Nuclear Receptor RORγ. Frontiers in Molecular Biosciences 9.
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Azam Rashidian, Enni-Kaisa Mustonen, Thales Kronenberger, Matthias Schwab, Oliver Burk, Stefan A. Laufer & Tatu Pantsar. (2022) Discrepancy in interactions and conformational dynamics of pregnane X receptor (PXR) bound to an agonist and a novel competitive antagonist. Computational and Structural Biotechnology Journal 20, pages 3004-3018.
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Sergio C. Chai & Taosheng Chen. 2022. Comprehensive Pharmacology. Comprehensive Pharmacology 151 164 .
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Xinran Cai, Ye Feng, Meishu Xu, Chaohui Yu & Wen Xie. (2021) Gadd45b is required in part for the anti-obesity effect of constitutive androstane receptor (CAR). Acta Pharmaceutica Sinica B 11:2, pages 434-441.
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Sergio C. Chai, William C. Wright & Taosheng Chen. (2019) Strategies for developing pregnane X receptor antagonists: Implications from metabolism to cancer. Medicinal Research Reviews 40:3, pages 1061-1083.
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Bill Pham, Avery Bancroft Arons, Jeremy G. Vincent, Elias J. Fernandez & Tongye Shen. (2019) Regulatory Mechanics of Constitutive Androstane Receptors: Basal and Ligand-Directed Actions. Journal of Chemical Information and Modeling 59:12, pages 5174-5182.
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Sergio C. Chai, Wenwei Lin, Yongtao Li & Taosheng Chen. (2019) Drug discovery technologies to identify and characterize modulators of the pregnane X receptor and the constitutive androstane receptor. Drug Discovery Today 24:3, pages 906-915.
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Manon Garcia, Laura Thirouard, Lauriane Sedès, Mélusine Monrose, Hélène Holota, Françoise Caira, David Volle & Claude Beaudoin. (2018) Nuclear Receptor Metabolism of Bile Acids and Xenobiotics: A Coordinated Detoxification System with Impact on Health and Diseases. International Journal of Molecular Sciences 19:11, pages 3630.
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Ben Niu, Denise M Coslo, Alain R Bataille, Istvan Albert, B Franklin Pugh & Curtis J Omiecinski. (2018) In vivo genome-wide binding interactions of mouse and human constitutive androstane receptors reveal novel gene targets. Nucleic Acids Research 46:16, pages 8385-8403.
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